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Volumn 69, Issue 8, 2014, Pages 477-489

Metformin and gynecologic cancers

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; METFORMIN; ANTINEOPLASTIC AGENT;

EID: 84906671466     PISSN: 00297828     EISSN: 15339866     Source Type: Journal    
DOI: 10.1097/OGX.0000000000000092     Document Type: Article
Times cited : (29)

References (124)
  • 1
    • 84856487711 scopus 로고    scopus 로고
    • Prevalence of obesity and trends in the distribution of body mass index among US adults 1999-2010
    • Flegal KM, Carroll MD, Kit BK, et al. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA. 2012;307:491-497.
    • (2012) JAMA , vol.307 , pp. 491-497
    • Flegal, K.M.1    Carroll, M.D.2    Kit, B.K.3
  • 2
    • 84906670118 scopus 로고    scopus 로고
    • Available at
    • National Health Examination Survey Data. Available at: http://www.cdc.gov/nchs/data/hestat/obesity-adult-09-10/obesity-adult-09-10.htm.
    • National Health Examination Survey Data
  • 3
    • 84906664825 scopus 로고    scopus 로고
    • National diabetes fact sheet 2011
    • A.D. Association, ed. National Diabetes Fact Sheet 2011. Centers for Disease Control; 2011.
    • (2011) Centers for Disease Control;
  • 4
    • 84906669707 scopus 로고    scopus 로고
    • National Cancer Institute National Cancer Institute at the National Institutes of Health fact sheet on obesity and cancer risk National Cancer Institute Web site Available at Reviewed April 22 2014
    • National Cancer Institute. National Cancer Institute at the National Institutes of Health fact sheet on obesity and cancer risk. National Cancer Institute Web site. Available at: http://www.cancer.gov/cancertopics/factsheet/ Risk/. Obesity. 2014. Reviewed April 22, 2014.
    • (2014) Obesity
  • 5
    • 84896949861 scopus 로고    scopus 로고
    • Metabolic syndrome-removing roadblocks to therapy: Antigenic immunotherapies
    • Coppieters KT, von Herrath MG. Metabolic syndrome-removing roadblocks to therapy: antigenic immunotherapies. Mol Metab. 2014;3:275-283.
    • (2014) Mol Metab. , vol.3 , pp. 275-283
    • Coppieters, K.T.1    Von Herrath, M.G.2
  • 7
    • 84880241715 scopus 로고    scopus 로고
    • Obesitydriven inflammation and cancer risk: Role of myeloid derived suppressor cells and alternately activated macrophages
    • Okwan-Duodu D, Umpierrez GE, Brawley OW, et al. Obesitydriven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages. Am J Cancer Res. 2013;3:21-33.
    • (2013) Am J Cancer Res. , vol.3 , pp. 21-33
    • Okwan-Duodu, D.1    Umpierrez, G.E.2    Brawley, O.W.3
  • 8
    • 0022260650 scopus 로고
    • Endometrial carcinoma. A retrospective, epidemiological study
    • Jensen H. Endometrial carcinoma. A retrospective, epidemiological study. Dan Med Bull. 1985;32:219-228. (Pubitemid 15014491)
    • (1985) Danish Medical Bulletin , vol.32 , Issue.4 , pp. 219-228
    • Jensen, H.1
  • 10
    • 78649302320 scopus 로고    scopus 로고
    • Metformin and cancer risk in diabetic patients: A systematic review and metaanalysis
    • Decensi A, Puntoni M, Goodwin P, et al. Metformin and cancer risk in diabetic patients: a systematic review and metaanalysis. Cancer Prev Res (Phila). 2010;3:1451-1461.
    • (2010) Cancer Prev Res (Phila). , vol.3 , pp. 1451-1461
    • Decensi, A.1    Puntoni, M.2    Goodwin, P.3
  • 12
    • 70749106139 scopus 로고    scopus 로고
    • Metformin is a potent inhibitor of endometrial cancer cell proliferation-implications for a novel treatment strategy
    • Cantrell LA, Zhou C, Mendivil A, et al. Metformin is a potent inhibitor of endometrial cancer cell proliferation-implications for a novel treatment strategy. Gynecol Oncol. 2010;116:92-98.
    • (2010) Gynecol Oncol. , vol.116 , pp. 92-98
    • Cantrell, L.A.1    Zhou, C.2    Mendivil, A.3
  • 14
    • 74249119959 scopus 로고    scopus 로고
    • Promising novel therapies for the treatment of endometrial cancer
    • Gehrig PA, Bae-Jump VL. Promising novel therapies for the treatment of endometrial cancer. Gynecol Oncol. 2010;116:187-194.
    • (2010) Gynecol Oncol. , vol.116 , pp. 187-194
    • Gehrig, P.A.1    Bae-Jump, V.L.2
  • 15
    • 84864285795 scopus 로고    scopus 로고
    • Management of hyperglycaemia in type 2 diabetes: A patient-centered approach. Position statement of the American Diabetes Association ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2012;55:1577-1596.
    • (2012) Diabetologia. , vol.55 , pp. 1577-1596
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 16
    • 84883165443 scopus 로고    scopus 로고
    • Repositioning metformin for cancer prevention and treatment
    • Quinn BJ, Kitagawa H, Memmott RM, et al. Repositioning metformin for cancer prevention and treatment. Trends Endocrinol Metab. 2013;24:469-480.
    • (2013) Trends Endocrinol Metab. , vol.24 , pp. 469-480
    • Quinn, B.J.1    Kitagawa, H.2    Memmott, R.M.3
  • 17
    • 33847150903 scopus 로고    scopus 로고
    • Pharmacologic therapy of polycystic ovary syndrome
    • DOI 10.1097/GRF.0b013e31802f35a0, PII 0000308120070300000022
    • Dronavalli S, Ehrmann DA. Pharmacologic therapy of polycystic ovary syndrome. Clin Obstet Gynecol. 2007;50:244-254. (Pubitemid 46279865)
    • (2007) Clinical Obstetrics and Gynecology , vol.50 , Issue.1 , pp. 244-254
    • Dronavalli, S.1    Ehrmann, D.A.2
  • 18
    • 33645766204 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    • Bowker SL,Majumdar SR, Veugelers P, et al. Increased cancerrelatedmortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care. 2006;29:254-258. (Pubitemid 44106500)
    • (2006) Diabetes Care , vol.29 , Issue.2 , pp. 254-258
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3    Johnson, J.A.4
  • 19
    • 69549097703 scopus 로고    scopus 로고
    • Newusers of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes
    • Libby G, Donnelly LA, Donnan PT, et al. Newusers of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care. 2009;32:1620-1625.
    • (2009) Diabetes Care. , vol.32 , pp. 1620-1625
    • Libby, G.1    Donnelly, L.A.2    Donnan, P.T.3
  • 20
    • 84866322945 scopus 로고    scopus 로고
    • Investigating metformin for cancer prevention and treatment: The end of the beginning
    • Pollak MN. Investigating metformin for cancer prevention and treatment: the end of the beginning. Cancer Discov. 2012;2:778-790.
    • (2012) Cancer Discov. , vol.2 , pp. 778-790
    • Pollak, M.N.1
  • 21
    • 84864075329 scopus 로고    scopus 로고
    • Dual effect of metformin on breast cancer proliferation in a randomized presurgical trial
    • Bonanni B, Puntoni M, Cazzaniga M, et al. Dual effect of metformin on breast cancer proliferation in a randomized presurgical trial. J Clin Oncol. 2012;30:2593-2600.
    • (2012) J Clin Oncol. , vol.30 , pp. 2593-2600
    • Bonanni, B.1    Puntoni, M.2    Cazzaniga, M.3
  • 22
    • 84872279633 scopus 로고    scopus 로고
    • Phase i trial of exemestane in combination with metformin and rosiglitazone in nondiabetic obese postmenopausal women with hormone receptor-positive metastatic breast cancer
    • Esteva FJ, Moulder SL, Gonzalez-Angulo AM, et al. Phase I trial of exemestane in combination with metformin and rosiglitazone in nondiabetic obese postmenopausal women with hormone receptor-positive metastatic breast cancer. Cancer Chemother Pharmacol. 2013;71:63-72.
    • (2013) Cancer Chemother Pharmacol. , vol.71 , pp. 63-72
    • Esteva, F.J.1    Moulder, S.L.2    Gonzalez-Angulo, A.M.3
  • 23
    • 77956411030 scopus 로고    scopus 로고
    • Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial
    • Hosono K, Endo H, Takahashi H, et al. Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial. Cancer Prev Res (Phila). 2010;3:1077-1083.
    • (2010) Cancer Prev Res (Phila). , vol.3 , pp. 1077-1083
    • Hosono, K.1    Endo, H.2    Takahashi, H.3
  • 24
    • 84862248731 scopus 로고    scopus 로고
    • A phase i study of temsirolimus and metformin in advanced solid tumours
    • MacKenzie MJ, Ernst S, Johnson C, et al. A phase I study of temsirolimus and metformin in advanced solid tumours. Invest New Drugs. 2012;30:647-652.
    • (2012) Invest New Drugs. , vol.30 , pp. 647-652
    • MacKenzie, M.J.1    Ernst, S.2    Johnson, C.3
  • 25
    • 84860351010 scopus 로고    scopus 로고
    • A prospective, randomized pilot study evaluating the effects ofmetformin and lifestyle intervention on patients with prostate cancer receiving androgen deprivation therapy
    • Nobes JP, Langley SE, Klopper T, et al. A prospective, randomized pilot study evaluating the effects ofmetformin and lifestyle intervention on patients with prostate cancer receiving androgen deprivation therapy. BJU Int. 2012;109:1495-1502.
    • (2012) BJU Int. , vol.109 , pp. 1495-1502
    • Nobes, J.P.1    Langley, S.E.2    Klopper, T.3
  • 26
    • 84864314304 scopus 로고    scopus 로고
    • Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer
    • He X, Esteva FJ, Ensor J, et al. Metformin and thiazolidinediones are associated with improved breast cancer-specific survival of diabetic women with HER2+ breast cancer. Ann Oncol. 2012;23:1771-1780.
    • (2012) Ann Oncol. , vol.23 , pp. 1771-1780
    • He, X.1    Esteva, F.J.2    Ensor, J.3
  • 27
    • 80053504259 scopus 로고    scopus 로고
    • Thiazolidinediones and metformin associated with improved survival of diabetic prostate cancer patients
    • He XX, Tu SM, Lee MH, et al. Thiazolidinediones and metformin associated with improved survival of diabetic prostate cancer patients. Ann Oncol. 2011;22:2640-2645.
    • (2011) Ann Oncol. , vol.22 , pp. 2640-2645
    • He, X.X.1    Tu, S.M.2    Lee, M.H.3
  • 29
  • 30
    • 84873707522 scopus 로고    scopus 로고
    • Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
    • Miller RA, Chu Q, Xie J, et al. Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature. 2013;494:256-260.
    • (2013) Nature. , vol.494 , pp. 256-260
    • Miller, R.A.1    Chu, Q.2    Xie, J.3
  • 32
    • 84897960120 scopus 로고    scopus 로고
    • An increase in the Akkermansia spp. Population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
    • Shin NR, Lee JC, Lee HY, et al. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut. 2014; 63:727-735.
    • (2014) Gut. , vol.63 , pp. 727-735
    • Shin, N.R.1    Lee, J.C.2    Lee, H.Y.3
  • 34
    • 84884211823 scopus 로고    scopus 로고
    • Targeting metabolism for cancer treatment and prevention: Metformin, an old drug with multi-faceted effects
    • Pierotti MA, Berrino F, Gariboldi M, et al. Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects. Oncogene. 2012;12:1475-1487.
    • (2012) Oncogene. , vol.12 , pp. 1475-1487
    • Pierotti, M.A.1    Berrino, F.2    Gariboldi, M.3
  • 35
    • 0026786085 scopus 로고
    • Receptors for hormones and growth factors and (onco)-gene amplification in human ovarian cancer
    • Berns EM, Klijn JG, Henzen-Logmans SC, et al. Receptors for hormones and growth factors and (onco)-gene amplification in human ovarian cancer. Int J Cancer. 1992; 52:218-224.
    • (1992) Int J Cancer. , vol.52 , pp. 218-224
    • Berns, E.M.1    Klijn, J.G.2    Henzen-Logmans, S.C.3
  • 36
    • 0028610516 scopus 로고
    • Expression of c-erbB-2, c-myc, and c-ras oncoproteins, insulin-like growth factor receptor I, and epidermal growth factor receptor in ovarian carcinoma
    • van Dam PA, Vergote IB, Lowe DG, et al. Expression of c-erbB-2, c-myc, and c-ras oncoproteins, insulin-like growth factor receptor I, and epidermal growth factor receptor in ovarian carcinoma. J Clin Pathol. 1994;47:914-919.
    • (1994) J Clin Pathol. , vol.47 , pp. 914-919
    • Van Dam, P.A.1    Vergote, I.B.2    Lowe, D.G.3
  • 39
    • 33751278008 scopus 로고    scopus 로고
    • Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium
    • DOI 10.1158/1078-0432.CCR-06-0912
    • McCampbell AS, Broaddus RR, Loose DS, et al. Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium. Clin Cancer Res. 2006;12:6373-6378. (Pubitemid 44799707)
    • (2006) Clinical Cancer Research , vol.12 , Issue.21 , pp. 6373-6378
    • McCampbell, A.S.1    Broaddus, R.R.2    Loose, D.S.3    Davies, P.J.A.4
  • 40
    • 0036428714 scopus 로고    scopus 로고
    • Alteration of PTEN expression in endometrial carcinoma is associated with down-regulation of cyclin-dependent kinase inhibitor p27
    • An HJ, Lee YH, Cho NH, et al. Alteration of PTEN expression in endometrial carcinoma is associated with down-regulation of cyclin-dependent kinase inhibitor, p27. Histopathology. 2002; 41:437-445.
    • (2002) Histopathology. , vol.41 , pp. 437-445
    • An, H.J.1    Lee, Y.H.2    Cho, N.H.3
  • 42
    • 0034616634 scopus 로고    scopus 로고
    • Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
    • Mutter GL, Lin MC, Fitzgerald JT, et al. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst. 2000;92:924-930.
    • (2000) J Natl Cancer Inst. , vol.92 , pp. 924-930
    • Mutter, G.L.1    Lin, M.C.2    Fitzgerald, J.T.3
  • 43
    • 0038274803 scopus 로고    scopus 로고
    • Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer
    • DOI 10.1677/erc.0.0100203
    • Terakawa N, Kanamori Y, Yoshida S. Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer. Endocr Relat Cancer. 2003;10:203-208. (Pubitemid 36758649)
    • (2003) Endocrine-Related Cancer , vol.10 , Issue.2 , pp. 203-208
    • Terakawa, N.1    Kanamori, Y.2    Yoshida, S.3
  • 44
    • 63849308483 scopus 로고    scopus 로고
    • Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation
    • Salvesen HB, Carter SL, Mannelqvist M, et al. Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation. Proc Natl Acad Sci USA. 2009;106:4834-4839.
    • (2009) Proc Natl Acad Sci USA. , vol.106 , pp. 4834-4839
    • Salvesen, H.B.1    Carter, S.L.2    Mannelqvist, M.3
  • 45
    • 28244490997 scopus 로고    scopus 로고
    • High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma
    • DOI 10.1158/0008-5472.CAN-05-2620
    • Oda K, Stokoe D, Taketani Y, et al. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Cancer Res. 2005;65:10669-10673. (Pubitemid 41713332)
    • (2005) Cancer Research , vol.65 , Issue.23 , pp. 10669-10673
    • Oda, K.1    Stokoe, D.2    Taketani, Y.3    McCormick, F.4
  • 46
    • 63949083916 scopus 로고    scopus 로고
    • Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis
    • Catasus L, Gallardo A, Cuatrecasas M, et al. Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis. Mod Pathol. 2009;22: 522-529.
    • (2009) Mod Pathol. , vol.22 , pp. 522-529
    • Catasus, L.1    Gallardo, A.2    Cuatrecasas, M.3
  • 47
    • 67349170390 scopus 로고    scopus 로고
    • Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma
    • Hayes MP, Douglas W, Ellenson LH. Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma. Gynecol Oncol. 2009;113:370-373.
    • (2009) Gynecol Oncol. , vol.113 , pp. 370-373
    • Hayes, M.P.1    Douglas, W.2    Ellenson, L.H.3
  • 48
    • 38949121953 scopus 로고    scopus 로고
    • PIK3CA gene mutations and amplifications in uterine cancers, identified by methods that avoid confounding by PIK3CA pseudogene sequences
    • Miyake T, Yoshino K, Enomoto T, et al. PIK3CA gene mutations and amplifications in uterine cancers, identified by methods that avoid confounding by PIK3CA pseudogene sequences. Cancer Lett. 2008;261:120-126.
    • (2008) Cancer Lett. , vol.261 , pp. 120-126
    • Miyake, T.1    Yoshino, K.2    Enomoto, T.3
  • 49
    • 80054778946 scopus 로고    scopus 로고
    • High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability
    • Cheung LW, Hennessy BT, Li J, et al. High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discov. 2011;1:170-185.
    • (2011) Cancer Discov. , vol.1 , pp. 170-185
    • Cheung, L.W.1    Hennessy, B.T.2    Li, J.3
  • 51
    • 0029127042 scopus 로고
    • Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
    • Bellacosa A, de Feo D, Godwin AK, et al. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer. 1995;64:280-285.
    • (1995) Int J Cancer. , vol.64 , pp. 280-285
    • Bellacosa, A.1    De Feo, D.2    Godwin, A.K.3
  • 56
    • 84890538979 scopus 로고    scopus 로고
    • Another surprise from metformin: Novel mechanism of action via K-ras influences endometrial cancer response to therapy
    • Iglesias DA, Yates MS, van der Hoeven D, et al. Another surprise from metformin: novel mechanism of action via K-ras influences endometrial cancer response to therapy. Mol Cancer Ther. 2013;12:2847-2856.
    • (2013) Mol Cancer Ther. , vol.12 , pp. 2847-2856
    • Iglesias, D.A.1    Yates, M.S.2    Van Der Hoeven, D.3
  • 57
    • 84876423635 scopus 로고    scopus 로고
    • Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or-independent manners
    • Sarfstein R, Friedman Y, Attias-Geva Z, et al. Metformin downregulates the insulin/IGF-I signaling pathway and inhibits different uterine serous carcinoma (USC) cells proliferation and migration in p53-dependent or-independent manners. PLoS One. 2013;8:e61537.
    • (2013) PLoS One. , vol.8
    • Sarfstein, R.1    Friedman, Y.2    Attias-Geva, Z.3
  • 58
    • 84858745832 scopus 로고    scopus 로고
    • Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway
    • Hanna RK, Zhou C, Malloy KM, et al. Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway. Gynecol Oncol. 2012;125:458-469.
    • (2012) Gynecol Oncol. , vol.125 , pp. 458-469
    • Hanna, R.K.1    Zhou, C.2    Malloy, K.M.3
  • 59
    • 84864619407 scopus 로고    scopus 로고
    • Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase i expression
    • Dong L, Zhou Q, Zhang Z, et al. Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase I expression. J Obstet Gynaecol Res. 2012;38:1077-1085.
    • (2012) J Obstet Gynaecol Res. , vol.38 , pp. 1077-1085
    • Dong, L.1    Zhou, Q.2    Zhang, Z.3
  • 60
    • 67650088379 scopus 로고    scopus 로고
    • Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia
    • Erdemoglu E, Guney M, Giray SG, et al. Effects of metformin on mammalian target of rapamycin in a mouse model of endometrial hyperplasia. Eur J Obstet Gynecol Reprod Biol. 2009; 145:195-199.
    • (2009) Eur J Obstet Gynecol Reprod Biol. , vol.145 , pp. 195-199
    • Erdemoglu, E.1    Guney, M.2    Giray, S.G.3
  • 61
    • 79952290187 scopus 로고    scopus 로고
    • Metformin treatment exerts antiinvasive and antimetastatic effects in human endometrial carcinoma cells
    • Tan BK, Adya R, Chen J, et al. Metformin treatment exerts antiinvasive and antimetastatic effects in human endometrial carcinoma cells. J Clin Endocrinol Metab. 2011;96:808-816.
    • (2011) J Clin Endocrinol Metab. , vol.96 , pp. 808-816
    • Tan, B.K.1    Adya, R.2    Chen, J.3
  • 62
    • 79956141892 scopus 로고    scopus 로고
    • Metformin reverses progestin resistance in endometrial cancer cells by downregulating GloI expression
    • Zhang Z, Dong L, Sui L, et al. Metformin reverses progestin resistance in endometrial cancer cells by downregulating GloI expression. Int J Gynecol Cancer. 2011;21:213-221.
    • (2011) Int J Gynecol Cancer. , vol.21 , pp. 213-221
    • Zhang, Z.1    Dong, L.2    Sui, L.3
  • 63
    • 84863230219 scopus 로고    scopus 로고
    • Metformin: A potential novel endometrial cancer therapy
    • Mu N, Wang Y, Xue F. Metformin: a potential novel endometrial cancer therapy. Int J Gynecol Cancer. 2012;22:181.
    • (2012) Int J Gynecol Cancer. , vol.22 , pp. 181
    • Mu, N.1    Wang, Y.2    Xue, F.3
  • 64
    • 84865317251 scopus 로고    scopus 로고
    • Metformin inhibits the development and metastasis of ovarian cancer
    • Wu B, Li S, Sheng L, et al. Metformin inhibits the development and metastasis of ovarian cancer. Oncol Rep. 2012;28:903-908.
    • (2012) Oncol Rep. , vol.28 , pp. 903-908
    • Wu, B.1    Li, S.2    Sheng, L.3
  • 65
    • 79957438835 scopus 로고    scopus 로고
    • Induction of apoptosis by metformin in epithelial ovarian cancer: Involvement of the Bcl-2 family proteins
    • Yasmeen A, Beauchamp MC, Piura E, et al. Induction of apoptosis by metformin in epithelial ovarian cancer: involvement of the Bcl-2 family proteins. Gynecol Oncol. 2011;121:492-498.
    • (2011) Gynecol Oncol. , vol.121 , pp. 492-498
    • Yasmeen, A.1    Beauchamp, M.C.2    Piura, E.3
  • 66
    • 84860784421 scopus 로고    scopus 로고
    • Luteinizing hormone facilitates angiogenesis in ovarian epithelial tumor cells and metformin inhibits the effect through the mTOR signaling pathway
    • Liao H, Zhou Q, Gu Y, et al. Luteinizing hormone facilitates angiogenesis in ovarian epithelial tumor cells and metformin inhibits the effect through the mTOR signaling pathway. Oncol Rep. 2012;27:1873-1878.
    • (2012) Oncol Rep. , vol.27 , pp. 1873-1878
    • Liao, H.1    Zhou, Q.2    Gu, Y.3
  • 67
    • 78751692291 scopus 로고    scopus 로고
    • Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner
    • Rattan R, Giri S, Hartmann LC, et al. Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner. J Cell Mol Med. 2011;15:166-178.
    • (2011) J Cell Mol Med. , vol.15 , pp. 166-178
    • Rattan, R.1    Giri, S.2    Hartmann, L.C.3
  • 68
    • 79955834631 scopus 로고    scopus 로고
    • Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo
    • Rattan R, Graham RP, Maguire JL, et al. Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo. Neoplasia. 2011;13: 483-491.
    • (2011) Neoplasia. , vol.13 , pp. 483-491
    • Rattan, R.1    Graham, R.P.2    Maguire, J.L.3
  • 69
    • 84863229883 scopus 로고    scopus 로고
    • LY294002 and metformin cooperatively enhance the inhibition of growth and the induction of apoptosis of ovarian cancer cells
    • Li C, Liu VW, Chan DW, et al. LY294002 and metformin cooperatively enhance the inhibition of growth and the induction of apoptosis of ovarian cancer cells. Int J Gynecol Cancer. 2012;22:15-22.
    • (2012) Int J Gynecol Cancer. , vol.22 , pp. 15-22
    • Li, C.1    Liu, V.W.2    Chan, D.W.3
  • 70
    • 84863583356 scopus 로고    scopus 로고
    • Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer cultures
    • Chan DK, Miskimins WK. Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer cultures. J Ovarian Res. 2012;5:19.
    • (2012) J Ovarian Res. , vol.5 , pp. 19
    • Chan, D.K.1    Miskimins, W.K.2
  • 71
    • 84887496514 scopus 로고    scopus 로고
    • Metformin, at concentrations corresponding to the treatment of diabetes, potentiates the cytotoxic effects of carboplatin in cultures of ovarian cancer cells
    • Erices R, Bravo ML, Gonzalez P, et al. Metformin, at concentrations corresponding to the treatment of diabetes, potentiates the cytotoxic effects of carboplatin in cultures of ovarian cancer cells. Reprod Sci. 2013;20:1433-1446.
    • (2013) Reprod Sci. , vol.20 , pp. 1433-1446
    • Erices, R.1    Bravo, M.L.2    Gonzalez, P.3
  • 72
    • 84867405520 scopus 로고    scopus 로고
    • Metformin targets ovarian cancer stem cells in vitro and in vivo
    • Shank JJ, Yang K, Ghannam J, et al. Metformin targets ovarian cancer stem cells in vitro and in vivo. Gynecol Oncol. 2012;127: 390-397.
    • (2012) Gynecol Oncol. , vol.127 , pp. 390-397
    • Shank, J.J.1    Yang, K.2    Ghannam, J.3
  • 73
    • 47249088612 scopus 로고    scopus 로고
    • In vitro metformin anti-neoplastic activity in epithelial ovarian cancer.
    • Gotlieb WH, Saumet J, Beauchamp MC, et al. In vitro metformin anti-neoplastic activity in epithelial ovarian cancer. GynecolOncol. 2008;110:246-250.
    • (2008) GynecolOncol. , vol.110 , pp. 246-250
    • Gotlieb, W.H.1    Saumet, J.2    Beauchamp, M.C.3
  • 74
    • 53849118108 scopus 로고    scopus 로고
    • Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth
    • Algire C, Zakikhani M, Blouin MJ, et al. Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth. Endocr Relat Cancer. 2008;15:833-839.
    • (2008) Endocr Relat Cancer. , vol.15 , pp. 833-839
    • Algire, C.1    Zakikhani, M.2    Blouin, M.J.3
  • 75
    • 77956185559 scopus 로고    scopus 로고
    • Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy
    • Phoenix KN, Vumbaca F, Fox MM, et al. Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy. Breast Cancer Res Treat. 2009;2:333-344.
    • (2009) Breast Cancer Res Treat. , vol.2 , pp. 333-344
    • Phoenix, K.N.1    Vumbaca, F.2    Fox, M.M.3
  • 76
    • 84906664826 scopus 로고    scopus 로고
    • Metformin had increased efficacy under obese conditions in a novel genetically engineered mouse model of serous ovarian cancer
    • Paper presented at Tampa FL;
    • Jackson A, Zhong Y, Zhou C, et al. Metformin had increased efficacy under obese conditions in a novel genetically engineered mouse model of serous ovarian cancer. Paper presented at: Annual Meeting of the Society of Gynecologic Oncology. Tampa, FL; 2014.
    • (2014) Annual Meeting of the Society of Gynecologic Oncology
    • Jackson, A.1    Zhong, Y.2    Zhou, C.3
  • 79
    • 84897101178 scopus 로고    scopus 로고
    • The complex triad of obesity, diabetes and race in type i and II endometrial cancers: Prevalence and prognostic significance
    • Ko EM, Walter P, Clark L, et al. The complex triad of obesity, diabetes and race in type I and II endometrial cancers: prevalence and prognostic significance. Gynecol Oncol. 2014;133:28-32.
    • (2014) Gynecol Oncol. , vol.133 , pp. 28-32
    • Ko, E.M.1    Walter, P.2    Clark, L.3
  • 80
    • 84883854572 scopus 로고    scopus 로고
    • Type i and II endometrial cancers: Have they different risk factors?
    • Setiawan VW, Yang HP, Pike MC, et al. Type I and II endometrial cancers: have they different risk factors?J Clin Oncol. 2013;31:2607-2618.
    • (2013) J Clin Oncol. , vol.31 , pp. 2607-2618
    • Setiawan, V.W.1    Yang, H.P.2    Pike, M.C.3
  • 81
    • 81855170040 scopus 로고    scopus 로고
    • Understanding obesity and endometrial cancer risk: Opportunities for prevention
    • Schmandt RE, Iglesias DA, Co NN, et al. Understanding obesity and endometrial cancer risk: opportunities for prevention. Am J Obstet Gynecol. 2011;205:518-525.
    • (2011) Am J Obstet Gynecol. , vol.205 , pp. 518-525
    • Schmandt, R.E.1    Iglesias, D.A.2    Co, N.N.3
  • 82
    • 38949108241 scopus 로고    scopus 로고
    • Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies
    • DOI 10.1016/S0140-6736(08)60269-X, PII S014067360860269X
    • Renehan AG, Tyson M, Egger M, et al. Body-mass index and incidence of cancer: a systematic review and metaanalysis of prospective observational studies. Lancet. 2008;371: 569-578. (Pubitemid 351232031)
    • (2008) The Lancet , vol.371 , Issue.9612 , pp. 569-578
    • Renehan, A.G.1    Tyson, M.2    Egger, M.3    Heller, R.F.4    Zwahlen, M.5
  • 84
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
    • DOI 10.1056/NEJMoa021423
    • Calle EE, Rodriguez C, Walker-Thurmond K, et al. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348:1625-1638. (Pubitemid 36459468)
    • (2003) New England Journal of Medicine , vol.348 , Issue.17 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 86
    • 84874887864 scopus 로고    scopus 로고
    • Prediagnosis body mass index, physical activity, and mortality in endometrial cancer patients
    • Arem H, Park Y, Pelser C, et al. Prediagnosis body mass index, physical activity, and mortality in endometrial cancer patients. J Natl Cancer Inst. 2013;105:342-349.
    • (2013) J Natl Cancer Inst. , vol.105 , pp. 342-349
    • Arem, H.1    Park, Y.2    Pelser, C.3
  • 87
    • 84862881737 scopus 로고    scopus 로고
    • Cardiovascular disease is the leading cause of death among endometrial cancer patients
    • Ward KK, Shah NR, Saenz CC, et al. Cardiovascular disease is the leading cause of death among endometrial cancer patients. Gynecol Oncol. 2012;126:176-179.
    • (2012) Gynecol Oncol. , vol.126 , pp. 176-179
    • Ward, K.K.1    Shah, N.R.2    Saenz, C.C.3
  • 88
    • 0020660717 scopus 로고
    • Two pathogenetic types of endometrial carcinoma
    • DOI 10.1016/0090-8258(83)90111-7
    • Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol. 1983;15:10-17. (Pubitemid 13194678)
    • (1983) Gynecologic Oncology , vol.15 , Issue.1 , pp. 10-17
    • Bokhman, J.V.1
  • 89
    • 80054767295 scopus 로고    scopus 로고
    • Use of metformin and the risk of ovarian cancer: A case-control analysis
    • Bodmer M, Becker C, Meier C, et al. Use of metformin and the risk of ovarian cancer: a case-control analysis. Gynecol Oncol. 2011;123:200-204.
    • (2011) Gynecol Oncol. , vol.123 , pp. 200-204
    • Bodmer, M.1    Becker, C.2    Meier, C.3
  • 90
    • 84255169908 scopus 로고    scopus 로고
    • Relationship of type II diabetes andmetformin use to ovarian cancer progression, survival, and chemosensitivity
    • Romero IL, McCormick A, McEwen KA, et al. Relationship of type II diabetes andmetformin use to ovarian cancer progression, survival, and chemosensitivity. Obstet Gynecol. 2012;119:61-67.
    • (2012) Obstet Gynecol. , vol.119 , pp. 61-67
    • Romero, I.L.1    McCormick, A.2    McEwen, K.A.3
  • 91
    • 84872978681 scopus 로고    scopus 로고
    • Metformin intake is associated with better survival in ovarian cancer: A case-control study
    • Kumar S, Meuter A, Thapa P, et al. Metformin intake is associated with better survival in ovarian cancer: a case-control study. Cancer. 2013;119:555-562.
    • (2013) Cancer. , vol.119 , pp. 555-562
    • Kumar, S.1    Meuter, A.2    Thapa, P.3
  • 92
    • 84859029647 scopus 로고    scopus 로고
    • Mortality after incident cancer in people with and without type 2 diabetes: Impact of metformin on survival
    • Currie CJ, Poole CD, Jenkins-Jones S, et al. Mortality after incident cancer in people with and without type 2 diabetes: impact of metformin on survival. Diabetes Care. 2012;35:299-304.
    • (2012) Diabetes Care. , vol.35 , pp. 299-304
    • Currie, C.J.1    Poole, C.D.2    Jenkins-Jones, S.3
  • 93
    • 84877576018 scopus 로고    scopus 로고
    • Metformin and the risk of endometrial cancer: A case-control analysis
    • Becker C, Jick SS, Meier CR, et al. Metformin and the risk of endometrial cancer: a case-control analysis. Gynecol Oncol. 2013;129:565-569.
    • (2013) Gynecol Oncol. , vol.129 , pp. 565-569
    • Becker, C.1    Jick, S.S.2    Meier, C.R.3
  • 95
    • 84894041491 scopus 로고    scopus 로고
    • Metformin is associated with improved survival in endometrial cancer
    • Ko EM, Walter P, Jackson A, et al. Metformin is associated with improved survival in endometrial cancer. Gynecol Oncol. 2014;132:438-442.
    • (2014) Gynecol Oncol. , vol.132 , pp. 438-442
    • Ko, E.M.1    Walter, P.2    Jackson, A.3
  • 96
    • 84906664823 scopus 로고    scopus 로고
    • Metformin and the risk of endometrial cancer: A population-based cohort study
    • Paper presented at Tampa FL
    • Ko E, Stürmer T, Hong JL, et al. Metformin and the risk of endometrial cancer: a population-based cohort study. Paper presented at: Annual Meeting of the Society of Gynecologic Oncology. Tampa, FL; 2014.
    • (2014) Annual Meeting of the Society of Gynecologic Oncology
    • Ko, E.1    Stürmer, T.2    Hong, J.L.3
  • 97
    • 84906697683 scopus 로고    scopus 로고
    • Cancer.org Available at
    • Cancer.org. Survival rates for ovarian cancer, by stage. Available at: http://www.cancer.org/cancer/ovariancancer/detailedguide/ovarian-cancer- survival-rates. 2014.
    • (2014) Survival Rates for Ovarian Cancer, by Stage
  • 98
    • 33644931626 scopus 로고    scopus 로고
    • Worldwide burden of gynaecological cancer: The size of the problem
    • DOI 10.1016/j.bpobgyn.2005.10.007, PII S1521693405001422, Gynaecological Cancer Screening and Prevention
    • Sankaranarayanan R, Ferlay J. Worldwide burden of gynaecological cancer: the size of the problem. Best Pract Res Clin Obstet Gynaecol. 2006;20:207-225. (Pubitemid 43380597)
    • (2006) Best Practice and Research: Clinical Obstetrics and Gynaecology , vol.20 , Issue.2 , pp. 207-225
    • Sankaranarayanan, R.1    Ferlay, J.2
  • 99
    • 84862809621 scopus 로고    scopus 로고
    • American Cancer Society
    • American Cancer Society. Cancer Facts and Figures. 2012.
    • (2012) Cancer Facts and Figures
  • 100
    • 34250767630 scopus 로고    scopus 로고
    • Prognostic value of Ca 125 levels during primary therapy
    • MarkmannS,GerberB,Briese V.Prognostic value ofCa 125 levels during primary therapy. Anticancer Res. 2007;27:1837-1839. (Pubitemid 46954684)
    • (2007) Anticancer Research , vol.27 , Issue.4 A , pp. 1837-1839
    • Markmann, S.1    Gerber, B.2    Briese, V.3
  • 101
    • 84866452518 scopus 로고    scopus 로고
    • Obesity and ovarian cancer survival: A systematic review and meta-analysis
    • Protani MM, Nagle CM, Webb PM. Obesity and ovarian cancer survival: a systematic review and meta-analysis. Cancer Prev Res (Phila). 2012;5:901-910.
    • (2012) Cancer Prev Res (Phila). , vol.5 , pp. 901-910
    • Protani, M.M.1    Nagle, C.M.2    Webb, P.M.3
  • 102
    • 84863266838 scopus 로고    scopus 로고
    • Effect of obesity on survival of women with epithelial ovarian cancer: A systematic review and meta-analysis of observational studies
    • Yang HS, Yoon C, Myung SK, et al. Effect of obesity on survival of women with epithelial ovarian cancer: a systematic review and meta-analysis of observational studies. Int J Gynecol Cancer. 2011;21:1525-1532.
    • (2011) Int J Gynecol Cancer. , vol.21 , pp. 1525-1532
    • Yang, H.S.1    Yoon, C.2    Myung, S.K.3
  • 103
  • 105
    • 0038334133 scopus 로고    scopus 로고
    • Height and body mass index in relation to total mortality
    • DOI 10.1097/00001648-200305000-00008
    • Engeland A, Bjorge T, Selmer RM, et al. Height and body mass index in relation to total mortality. Epidemiology. 2003;14: 293-299. (Pubitemid 40417080)
    • (2003) Epidemiology , vol.14 , Issue.3 , pp. 293-299
    • Engeland, A.1    Bjorge, T.2    Selmer, R.M.3    Tverdal, A.4
  • 106
    • 84874486867 scopus 로고    scopus 로고
    • Trials and tribulations of interrogating biomarkers to define efficacy of cancer risk reductive interventions
    • Brenner DE, Hawk E. Trials and tribulations of interrogating biomarkers to define efficacy of cancer risk reductive interventions. Cancer Prev Res (Phila). 2013;6:71-73.
    • (2013) Cancer Prev Res (Phila). , vol.6 , pp. 71-73
    • Brenner, D.E.1    Hawk, E.2
  • 108
    • 77957355158 scopus 로고    scopus 로고
    • Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients
    • Patel KR, Brown VA, Jones DJ, et al. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Res. 2010;70:7392-7399.
    • (2010) Cancer Res. , vol.70 , pp. 7392-7399
    • Patel, K.R.1    Brown, V.A.2    Jones, D.J.3
  • 109
    • 80053894472 scopus 로고    scopus 로고
    • Effect of low-fat diets on plasma levels of NF-kappaB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer
    • Heymach JVK, Shackleford TJ, Tran HT, et al. Effect of low-fat diets on plasma levels of NF-kappaB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer. Cancer Prev Res (Phila). 2011;4:1590-1598.
    • (2011) Cancer Prev Res (Phila). , vol.4 , pp. 1590-1598
    • Heymach, J.V.K.1    Shackleford, T.J.2    Tran, H.T.3
  • 111
    • 79960845901 scopus 로고    scopus 로고
    • Evidence for biological effects of metformin in operable breast cancer: A pre-operative, window-of-opportunity, randomized trial
    • Hadad S, Iwamoto T, Jordan L, et al. Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Res Treat. 2011;128:783-794.
    • (2011) Breast Cancer Res Treat. , vol.128 , pp. 783-794
    • Hadad, S.1    Iwamoto, T.2    Jordan, L.3
  • 113
    • 84866538325 scopus 로고    scopus 로고
    • Metformin in early breast cancer: A prospective window of opportunity neoadjuvant study
    • Niraula S, Dowling RJ, Ennis M, et al. Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study. Breast Cancer Res Treat. 2012;135:821-830.
    • (2012) Breast Cancer Res Treat. , vol.135 , pp. 821-830
    • Niraula, S.1    Dowling, R.J.2    Ennis, M.3
  • 114
    • 84888870836 scopus 로고    scopus 로고
    • The effect of metformin on apoptosis in a breast cancer presurgical trial
    • Cazzaniga M, DeCensi A, Pruneri G, et al. The effect of metformin on apoptosis in a breast cancer presurgical trial. Br J Cancer. 2013;109:2792-2797.
    • (2013) Br J Cancer. , vol.109 , pp. 2792-2797
    • Cazzaniga, M.1    Decensi, A.2    Pruneri, G.3
  • 119
    • 33644664085 scopus 로고    scopus 로고
    • Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1
    • Kimura N, Masuda S, Tanihara Y, et al. Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet. 2005;20:379-386.
    • (2005) Drug Metab Pharmacokinet. , vol.20 , pp. 379-386
    • Kimura, N.1    Masuda, S.2    Tanihara, Y.3
  • 120
    • 16844384592 scopus 로고    scopus 로고
    • Metformin transport by renal basolateral organic cation transporter hOCT2
    • DOI 10.1007/s11095-004-1193-3
    • Kimura N, Okuda M, Inui K. Metformin transport by renal basolateral organic cation transporter hOCT2. Pharm Res. 2005;22:255-259. (Pubitemid 40487209)
    • (2005) Pharmaceutical Research , vol.22 , Issue.2 , pp. 255-259
    • Kimura, N.1    Okuda, M.2    Inui, K.-I.3
  • 121
    • 33746508758 scopus 로고    scopus 로고
    • Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1
    • DOI 10.1007/s11095-006-9016-3
    • Terada T, Masuda S, Asaka J, et al. Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1. Pharm Res. 2006;23:1696-1701. (Pubitemid 44200531)
    • (2006) Pharmaceutical Research , vol.23 , Issue.8 , pp. 1696-1701
    • Terada, T.1    Masuda, S.2    Asaka, J.-I.3    Tsuda, M.4    Katsura, T.5    Inui, K.-I.6
  • 123
    • 34748922537 scopus 로고    scopus 로고
    • Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine
    • DOI 10.1124/dmd.107.015495
    • Zhou M, Xia L, Wang J. Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine. Drug Metab Dispos. 2007;35:1956-1962. (Pubitemid 47481592)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.10 , pp. 1956-1962
    • Zhou, M.1    Xia, L.2    Wang, J.3


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