Induction of apoptosis by metformin in epithelial ovarian cancer: Involvement of the Bcl-2 family proteins

Gynecologic Oncology

Volumn 121, Issue 3, 2011, Pages 492-498

  Yasmeen, Amber ^a,b   Beauchamp, Marie Claude ^a,b   Piura, Ettie ^b,c   Segal, Eric ^a,b   Pollak, Michael ^b,c   Gotlieb, Walter H ^a,b,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Apoptosis; Bcl 2; Metformin; Ovarian cancer

Indexed keywords

CASPASE 3; CASPASE 7; CISPLATIN; METFORMIN; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOWN REGULATION; EPTHELIAL OVARIAN CANCER; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL LINE; WESTERN BLOTTING;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CISPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLOW CYTOMETRY; HUMANS; METFORMIN; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 79957438835     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2011.02.021     Document Type: Article

References (37)

1. A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu, and T. Murray Cancer statistics, 2008 CA Cancer J Clin 58 2008 71 96 (Pubitemid 351521864)
2. J.R. Chien, G. Aletti, D.A. Bell, G.L. Keeney, V. Shridhar, and L.C. Hartmann Molecular pathogenesis and therapeutic targets in epithelial ovarian cancer J Cell Biochem 102 2007 117 129
3. G.D. Aletti, M.M. Gallenberg, W.A. Cliby, A. Jatoi, and L.C. Hartmann Current management strategies for ovarian cancer Mayo Clin Proc 82 2007 751 770 (Pubitemid 46878099)
4. S.L. Bowker, S.R. Majumdar, P. Veugelers, and J.A. Johnson Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin Diab Care 29 2006 254 258 (Pubitemid 44106500)
5. J.M. Evans, L.A. Donnelly, A.M. Emslie-Smith, D.R. Alessi, and A.D. Morris Metformin and reduced risk of cancer in diabetic patients BMJ 330 2005 1304 1305 (Pubitemid 40813563)
6. G. Libby, L.A. Donnelly, P.T. Donnan, D.R. Alessi, A.D. Morris, and J.M. Evans New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes Diab Care 32 2009 1620 1625
7. S. Jiralerspong, S.L. Palla, S.H. Giordano, F. Meric-Bernstam, C. Liedtke, and C.M. Barnett Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer J Clin Oncol 27 2009 3297 3302
8. R.J. Shaw, K.A. Lamia, D. Vasquez, S.H. Koo, N. Bardeesy, and R.A. Depinho The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin Science 310 2005 1642 1646 (Pubitemid 41780780)
9. G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, and J. Fenyk-Melody Role of AMP-activated protein kinase in mechanism of metformin action J Clin Invest 108 2001 1167 1174 (Pubitemid 32995375)
10. D.A. Fruman, and A.L. Edinger Cancer therapy: staying current with AMPK Biochem J 412 2008 e3 e5
11. S.M. Hadad, S. Fleming, and A.M. Thompson Targeting AMPK: a new therapeutic opportunity in breast cancer Crit Rev Oncol Hematol 67 2008 1 7
12. W. Wang, and K.L. Guan AMP-activated protein kinase and cancer Acta Physiol (Oxf) 196 2009 55 63
13. W.H. Gotlieb, J. Saumet, M.C. Beauchamp, J. Gu, S. Lau, and M.N. Pollak In vitro metformin anti-neoplastic activity in epithelial ovarian cancer Gynecol Oncol 110 2008 246 250
14. A. Frenzel, F. Grespi, W. Chmelewskij, and A. Villunger Bcl2 family proteins in carcinogenesis and the treatment of cancer Apoptosis 14 2009 584 596
15. K.W. Yip, and J.C. Reed Bcl-2 family proteins and cancer Oncogene 27 2008 6398 6406
16. M. Marone, G. Scambia, S. Mozzetti, G. Ferrandina, S. Iacovella, and A. De Pasqua bcl-2, bax, bcl-XL, and bcl-XS expression in normal and neoplastic ovarian tissues Clin Cancer Res 4 1998 517 524 (Pubitemid 28122771)
17. I. Skirnisdottir, T. Seidal, E. Gerdin, and B. Sorbe The prognostic importance of p53, bcl-2, and bax in early stage epithelial ovarian carcinoma treated with adjuvant chemotherapy Int J Gynecol Cancer 12 2002 265 276 (Pubitemid 34787554)
18. S.K. Kassim, H.S. Ali, M.M. Sallam, S.T. Fayed, L.S. Seada, and E. abd-Elkawy Increased bcl-2 expression is associated with primary resistance to chemotherapy in human epithelial ovarian cancer Clin Biochem 32 1999 333 338 (Pubitemid 29416723)
19. N.S. Anderson, Y. Bermudez, D. Badgwell, R. Chen, S.V. Nicosia, and R.C. Bast Jr. Urinary levels of Bcl-2 are elevated in ovarian cancer patients Gynecol Oncol 112 2009 60 67
20. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J Biol Chem 193 1951 265 275
21. M.C. Berenbaum Criteria for analyzing interactions between biologically active agents Adv Cancer Res 35 1981 269 335
22. J.H. Silber, P.R. Rosenbaum, D. Polsky, R.N. Ross, O. Even-Shoshan, and J.S. Schwartz Does ovarian cancer treatment and survival differ by the specialty providing chemotherapy? J Clin Oncol 25 2007 1169 1175 (Pubitemid 46640562)
23. T.J. Herzog, and B. Pothuri Ovarian cancer: a focus on management of recurrent disease Nat Clin Pract Oncol 3 2006 604 611 (Pubitemid 44669715)
24. V.M. Dilman Age-associated elevation of hypothalamic, threshold to feedback control, and its role in development, ageine, and disease Lancet 1 1971 1211 1219
25. R. Rattan, S. Giri, L. Hartmann, and V. Shridhar Metformin attenuates ovarian cancer cell growth in an AMP- kinase dispensable manner J Cell Mol Med 2009
26. I. Ben Sahra, K. Laurent, A. Loubat, S. Giorgetti-Peraldi, P. Colosetti, and P. Auberger The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level Oncogene 27 2008 3576 3586 (Pubitemid 351793803)
27. I.N. Alimova, B. Liu, Z. Fan, S.M. Edgerton, T. Dillon, and S.E. Lind Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro Cell Cycle 8 2009 909 915
28. L.W. Wang, Z.S. Li, D.W. Zou, Z.D. Jin, J. Gao, and G.M. Xu Metformin induces apoptosis of pancreatic cancer cells World J Gastroenterol 14 2008 7192 7198
29. B. Liu, Z. Fan, S.M. Edgerton, X.S. Deng, I.N. Alimova, and S.E. Lind Metformin induces unique biological and molecular responses in triple negative breast cancer cells Cell Cycle 8 2009 2031 2040
30. I. Ben Sahra, K. Laurent, S. Giuliano, F. Larbret, G. Ponzio, and P. Gounon Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells Cancer Res 70 2010 2465 2475
31. A. Isakovic, L. Harhaji, D. Stevanovic, Z. Markovic, M. Sumarac-Dumanovic, and V. Starcevic Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis Cell Mol Life Sci 64 2007 1290 1302 (Pubitemid 46791062)
32. L.A. Cantrell, C. Zhou, A. Mendivil, K.M. Malloy, P.A. Gehrig, and V.L. Bae-Jump Metformin is a potent inhibitor of endometrial cancer cell proliferation-implications for a novel treatment strategy Gynecol Oncol 116 2010 92 98
33. H. Takane, E. Shikata, K. Otsubo, S. Higuchi, and I. Ieiri Polymorphism in human organic cation transporters and metformin action Pharmacogenomics 9 2008 415 422 (Pubitemid 351803926)
34. M.H. Kang, and C.P. Reynolds Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy Clin Cancer Res 15 2009 1126 1132
35. J.M. Adams, and S. Cory The Bcl-2 protein family: arbiters of cell survival Science 281 1998 1322 1326 (Pubitemid 28406819)
36. B. Martin-Castillo, A. Vazquez-Martin, C. Oliveras-Ferraros, and J.A. Menendez Metformin and cancer: doses, mechanisms and the dandelion and hormetic phenomena Cell Cycle 9 2010 1057 1064
37. M.R. Owen, E. Doran, and A.P. Halestrap Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain Biochem J 348 Pt 3 2000 607 614 (Pubitemid 30410251)