Metformin targets ovarian cancer stem cells in vitro and in vivo

Gynecologic Oncology

Volumn 127, Issue 2, 2012, Pages 390-397

  Shank, Jessica J ^a   Yang, Kun ^a   Ghannam, Jacob ^a   Cabrera, Lourdes ^a   Johnston, Carolyn J ^a   Reynolds, R Kevin ^a   Buckanovich, Ronald J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Angiogenesis; Cancer stem cells; Metformin; Ovarian cancer; Therapy

Indexed keywords

ALDEHYDE DEHYDROGENASE; CISPLATIN; METFORMIN;

ADD ON THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER STEM CELL; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; TARGET CELL DESTRUCTION; TUMOR XENOGRAFT;

ALDEHYDE DEHYDROGENASE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLOW CYTOMETRY; HUMANS; HYPOGLYCEMIC AGENTS; METFORMIN; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; OVARIAN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84867405520     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2012.07.115     Document Type: Article

References (25)

1. B.K. Edwards, M.L. Brown, P.A. Wingo, H.L. Howe, E. Ward, and L.A. Ries Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment J Natl Cancer Inst 97 2005 1407 1427
2. B.M. Boman, and M.S. Wicha Cancer stem cells: a step toward the cure J Clin Oncol 26 2008 2795 2799
3. D. Burgos-Ojeda, B.R. Rueda, and R.J. Buckanovich Ovarian cancer stem cell markers: prognostic and therapeutic implications Cancer Lett 322 2012 1 7
4. I.A. Silva, S. Bai, K. McLean, K. Yang, K. Griffith, and D. Thomas Aldehyde dehydrogenase in combination with CD133 defines angiogenic ovarian cancer stem cells that portend poor patient survival Cancer Res 71 2011 3991 4001
5. A. Vazquez-Martin, C. Oliveras-Ferraros, S. Cufi, S. Del Barco, B. Martin-Castillo, and J.A. Menendez Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status Cell Cycle 9 2010 3807 3814
6. H.A. Hirsch, D. Iliopoulos, P.N. Tsichlis, and K. Struhl Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission Cancer Res 69 2009 7507 7511
7. D. Iliopoulos, H.A. Hirsch, and K. Struhl Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types Cancer Res 71 2011 3196 3201
8. A. Vazquez-Martin, C. Oliveras-Ferraros, S.D. Barco, B. Martin-Castillo, and J.A. Menendez The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells Breast Cancer Res Treat 126 2011 355 364
9. W.H. Gotlieb, J. Saumet, M.C. Beauchamp, J. Gu, S. Lau, and M.N. Pollak In vitro metformin anti-neoplastic activity in epithelial ovarian cancer Gynecol Oncol 110 2008 246 250
10. A. Yasmeen, M.C. Beauchamp, E. Piura, E. Segal, M. Pollak, and W.H. Gotlieb Induction of apoptosis by metformin in epithelial ovarian cancer: involvement of the Bcl-2 family proteins Gynecol Oncol 121 2011 492 498
11. R. Rattan, R.P. Graham, J.L. Maguire, S. Giri, and V. Shridhar Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo Neoplasia 13 2011 483 491
12. H.L. Pulaski, G. Spahlinger, I.A. Silva, K. McLean, A.S. Kueck, and R.K. Reynolds Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer J Transl Med 7 2009 49
13. Zydus Pharmaceuticals (USA) Inc. Metformin: Official FDA information, side effects and uses 2011
14. S. Reagan-Shaw, M. Nihal, and N. Ahmad Dose translation from animal to human studies revisited FASEB J 22 2008 659 661
15. L. Zhao, M.G. Wientjes, and J.L. Au Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses Clin Cancer Res 10 2004 7994 8004
16. K. McLean, Y. Gong, Y. Choi, N. Deng, K. Yang, and S. Bai Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production J Clin Invest 121 2011 3206 3219
17. C. Li, V.W. Liu, D.W. Chan, K.M. Yao, and H.Y. Ngan LY294002 and metformin cooperatively enhance the inhibition of growth and the induction of apoptosis of ovarian cancer cells Int J Gynecol Cancer 22 2012 15 22
18. R. Rattan, S. Giri, L.C. Hartmann, and V. Shridhar Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner J Cell Mol Med 15 2011 166 178
19. C. Calabrese, H. Poppleton, M. Kocak, T.L. Hogg, C. Fuller, and B. Hamner A perivascular niche for brain tumor stem cells Cancer Cell 11 2007 69 82
20. Q. Shen, S.K. Goderie, L. Jin, N. Karanth, Y. Sun, and N. Abramova Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells Science 304 2004 1338 1340
21. S. Bao, Q. Wu, S. Sathornsumetee, Y. Hao, Z. Li, and A.B. Hjelmeland Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor Cancer Res 66 2006 7843 7848
22. M. Buzzai, R.G. Jones, R.K. Amaravadi, J.J. Lum, R.J. DeBerardinis, and F. Zhao Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth Cancer Res 67 2007 6745 6752
23. Cancer Genome Atlas Research Network Integrated genomic analyses of ovarian carcinoma Nature 474 2011 609 615
24. A. Bakhru, R.J. Buckanovich, and J.J. Griggs The impact of diabetes on survival in women with ovarian cancer Gynecol Oncol 121 2011 106 111
25. M. Bodmer, C. Becker, C. Meier, S.S. Jick, and C.R. Meier Use of metformin and the risk of ovarian cancer: a case-control analysis Gynecol Oncol 123 2011 200 204