Bioefficacy of Tea Catechins Associated with Milk Caseins Tested Using Different In Vitro Digestion Models

Food Digestion

Volumn 5, Issue 1-3, 2014, Pages 8-18

  Guri, A ^a   Haratifar, S ^a   Corredig, M ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Caco 2, HT29 MTX; Casein encapsulation; Digestion, SHIME; EGCG bioefficacy; Green tea polyphenols

Indexed keywords

EID: 84906333494     PISSN: 18691978     EISSN: 18691986     Source Type: Journal    
DOI: 10.1007/s13228-014-0035-y     Document Type: Article

References (60)

1. Khan N, Mukhtar H (2007) Tea polyphenols for health promotion. Life Sci 8:519–533
2. Koo MW, Cho CH (2004) Pharmacological effects of green tea on the gastrointestinal system. Eur J Pharm 500:177–185
3. Yang CS, Wang X, Lu G, Picinich SC (2009) Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer 9:429–439
4. Serafini M, Ghiselli A, Ferro-Luzzi A (1996) In vivo antioxidant effect of green and black tea in man. Eur J Clin Nutr 50:28–32
5. van het Hof KH, Kivits GA, Weststrate JA, Tijburg LB (1998) Bioavailability of catechins from tea: the effect of milk. Eur J Clin Nutr 52:356–359
6. Gross G, Jacobs DM, Peters S, Possemiers S, van Duynhoven J, Vaughan EE, Van de Wiele T (2010) In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong interindividual variability. J Agric Food Chem 58:10236–10246
7. Neilson AP, Ferruzzi MG (2011) Influence of formulation and processing on absorption and metabolism of flavan-3-ols from tea and cocoa. Annu Rev Food Sci Technol 2:125–151
8. Papadopoulou A, Frazier RA (2004) Characterization of protein–polyphenol interactions. Trends Food Sci Technol 15:186–190
9. Yang CS, Sang S, Lambert JD, Lee M (2008) Bioavailability issues in studying the health effects of plant polyphenolic compounds. Mol Nutr Food Res 52:S139–S151
10. Stoupi S, Williamson G, Viton F, Barron D, King LJ, Brown JE, Clifford MN (2010) In vivo bioavailability, absorption, excretion, and pharmacokinetics of [14C] procyanidin B2 in male rats. Drug Metab Dispos 38:287–291
11. Yang CS, Wang Z (1993) Tea and cancer. J Natl Cancer Inst 85:1038–1049
12. Adhami VM, Malik A, Zaman N, Sarfaraz S, Siddiqui IA, Syed DN, Afaq F, Pasha FS, Saleem M, Mukhtar H (2007) Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo. Clin Cancer Res 13:1611–1619
13. Jung YD, Ellis LM (2010) Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea. Int J Exp Pathol 82:309–316
14. Yamamoto T, Hsu S, Lewis J, Wataha J, Dickinson D, Singh B, Bollag WB, Lockwood P, Ueta E, Osaki T, Schuster G (2003) Green tea polyphenol causes differential oxidative environments in tumor versus normal epithelial cells. J Pharm Exp Ther 307(1):230–236
15. Hong J, Lu H, Meng X, Ryu JH, Hara Y, Yang CS (2002) Stability, cellular uptake, biotransformation, and efflux of tea polyphenol (−)-Epigallocatechin-3-Gallate in HT-29 human colon adenocarcinoma cells. Cancer Res 62:7241–7246
16. Haratifar S, Meckling KA, Corredig M (2014) Anti-proliferative activity of nanoencapsulated tea catechin in casein micelles, using HT29 colon cancer cells. J Dairy Sci 97:672–678
17. D’Agostino EM, Rossett D, Atkins D, Ferdinando D, Yakubov GE (2012) Interaction of tea polyphenols and food constituents with model gut epithelia: the protective role of the mucus gel layer. J Agric Food Chem 60:3318–3328
18. National Cancer Institute. Questions and answers about green tea. http://www.cancer.gov/cancertopics/pdq/cam/prostatesupplements/Patient/page3. Accessed 31 Aug 2013
19. Jian L, Xie LP, Lee AH, Binns CW (2004) Protective effect of green tea against prostate cancer: a case‐control study in southeast China. Int J Cancer 108:130–135
20. Zhou H, Sun X, Zhang L, Zhang P, Li J, Liu Y (2012) Fabrication of biopolymeric complex coacervation core micelles for efficient tea polyphenol delivery via a green process. Langmuir 28:14553–14561
21. Gülseren I, Guri A, Corredig M (2012) Encapsulation of tea polyphenols in nanoliposomes prepared with milk phospholipids and their effect on the viability of HT-29 human carcinoma cells. Food Dig 3:36–45
22. Ru Q, Yu H, Huang Q (2010) Encapsulation of epigallocatechin-3-gallate (EGCG) using oil-in-water (O/W) submicrometer emulsions stabilized by ι-carrageenan and β-lactoglobulin. J Agric Food Chem 58:10373–10381
23. Liang J, Li F, Fang Y, Yang W, An X, Zhao L, Xin Z, Cao L, Hu Q (2011) Synthesis, characterization and cytotoxicity studies of chitosan-coated tea polyphenols nanoparticles. Colloids Surf B: Biointerfaces 82:297–301
24. Dube A, Ng K, Nicolazzo JA, Larson I (2010) Effective use of reducing agents and nanoparticle encapsulation in stabilizing catechins in alkaline solution. Food Chem 122:662–667
25. Livney YD (2010) Milk proteins as vehicles for bioactives. Curr Opin Colloid Interface Sci 15:73–83
26. Shpigelman A, Israeli G, Livney YD (2010) Thermally-induced protein-polyphenol co-assemblies: beta lactoglobulin-based nanocomplexes as protective nanovehicles for EGCG. Food Hydrocoll 24:735–743
27. Maiti TK, Ghosh KS, Dasgupta S (2006) Interaction of (-)-epigallocatechin-3-gallate with human serum albumin: fluorescence, Fourier transform infrared, circular dichroism, and docking studies. Prot-Struc Funct Bioinform 64:355–362
28. Luck G, Liao H, Murray NJ, Grimmer HR, Warminski EE, Williamson MP, Lilley TH, Haslam E (1994) Polyphenols, astringency and proline-rich proteins. Phytochemistry 37:357–371
29. Bennick A (2002) Interaction of plant polyphenols with salivary proteins. Crit Rev Oral Biol Med 13:184–196
30. Arts MJTJ, Haenen GRMM, Wilms LC, Beetstra SAJN, Heijnen CGM, Voss HP, Bast A (2002) Interactions between flavonoids and proteins: effect on the total antioxidant capacity. J Agric Food Chem 50:1184–1187
31. Dubeau S, Samson G, Tajmir-Riahi H (2010) Dual effect of milk on the antioxidant capacity of green, Darjeeling, and English breakfast teas. Food Chem 122:539–545
32. Fang Z, Bhandari B (2010) Encapsulation of polyphenols—a review. Trends Food Sci Technol 21:510–523
33. Xiao J, Mao F, Yang F, Zhao Y, Zhang C, Yamamoto K (2011) Interaction of dietary polyphenols with bovine milk proteins: molecular structure–affinity relationship and influencing bioactivity aspects. Mol Nutr Food Res 55:1637–1645
34. Haratifar S, Corredig M (2014) Interactions between tea catechins and casein micelles and their impact on renneting functionality. Food Chem 143:27–32
35. Alexandropoulou I, Komaitis M, Kapsokefalou M (2006) Effects of iron, ascorbate, meat and casein on the antioxidant capacity of green tea under conditions of in vitro digestion. Food Chem 94:359–365
36. McDougall GJ, Stewart D (2005) The inhibitory effects of berry polyphenols on digestive enzymes. Biofactors 23:189–195
37. McDougall GJ, Kulkarni NN, Stewart D (2009) Current developments on the inhibitory effects of berry polyphenols on digestive enzymes. Biofactors 34:73–80
38. Hilgendorf C, Spahn‐Langguth H, Regardh CG, Lipka E, Amidon GL, Langguth P (2000) Caco‐2 versus caco‐2/HT29‐MTX co‐cultured cell lines: permeabilities via diffusion, inside‐ and outside‐directed carrier‐mediated transport. J Pharm Sci 89:63–75
39. Behrens I, Stenberg P, Artursson P, Kissel T (2001) Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells. Pharm Res 18:1138–1145
40. Ferruzzi MG, Green RJ (2006) Analysis of catechins from milk–tea beverages by enzyme assisted extraction followed by high performance liquid chromatography. Food Chem 99:484–491
41. Lesuffleur T, Barbat A, Dussaulx E, Zweibaum A (1990) Growth adaptation to methotrexate of HT-29 human colon carcinoma cells is associated with their ability to differentiate into columnar absorptive and mucus-secreting cells. Cancer Res 50:6334–6343
42. Guri A, Gülseren I, Corredig M (2013) Utilization of solid lipid nanoparticles for enhanced delivery of curcumin in cocultures of HT29-MTX and Caco-2 cells. Food Funct 4:1410–1419
43. Mahler GJ, Shuler ML, Glahn RP (2009) Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability. J Nutr Biochem 20:494–502
44. Nik AM, Wright AJ, Corredig M (2010) Surface adsorption alters the susceptibility of whey proteins to pepsin-digestion. J Colloid Interface Sci 344:372–381
45. Van den Abbeele P, Grootaert C, Marzorati M, Possemiers S, Verstraete W, Gérard P, Van de Wiele T (2010) Microbial community development in a dynamic gut model is reproducible, colon region specific, and selective for Bacteroidetes and Clostridium cluster IX. Appl Environ Microbiol 76:5237–5246
46. Ehrich M, Sharova L (2000) In vitro methods for detecting cytotoxicity. Curr Protoc Toxicol 3:2.6.1–2.6.27
47. Nik AM, Wright AJ, Corredig M (2011) Impact of interfacial composition on emulsion digestion and rate of lipid hydrolysis using different in vitro digestion models. Colloids Surf B: Biointerfaces 83:321–330
48. Skehan P, Storeng R, Scudiero D, Monks A, Mcmahon J, Vistica D, Warren JT, Bokesch H, Kenney S, Boyd MR (1990) New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 82:1107–1112
49. Salucci M, Stivala LA, Maiani G, Bugianesi R, Vannini V (2002) Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco-2). Br J Cancer 86:1645–1651
50. Bazinet L, Araya-Farias M, Doyen A, Trudel D, Tetu B (2010) Effect of process unit operations and long-term storage on catechin contents in EGCG-enriched tea drink. Food Res Int 43:1692–1701
51. Gonzalez de Mejia EG, Song YS, Heck CI, Ramirez-Mares MV (2010) Yerba mate tea (Ilex paraguariensis): phenolics, antioxidant capacity and in vitro inhibition of colon cancer cell proliferation. J Funct Foods 2:23–34
52. Chen D, Dou QP (2008) Tea polyphenols and their roles in cancer prevention and chemotherapy. Int J Mol Sci 9:1196–1206
53. Lopez de Lacey AM, Gimenez B, Perez-Santin E, Faulks R, Mandalari G, Lopez-Caballero ME, Montero P (2012) Bioaccessibility of green tea polyphenols incorporated into an edible agar film during simulated human digestion. Food Res Int 48:462–469
54. Cilla A, Perales S, Lagarda MJ, Barberá R, Clemente G, Farré R (2011) Influence of storage and in vitro gastrointestinal digestion on total antioxidant capacity of fruit beverages. J Food Compos Anal 24:87–94
55. Sharma V, Rao LJM (2009) A thought on the biological activities of black tea. Crit Rev Food Sci Nutr 49:379–404
56. Spencer JPE (2003) Metabolism of tea flavonoids in the gastrointestinal tract. J Nutr 133:3255S–3261S
57. Visioli F, Lastra CADL, Andres-Lacueva C, Aviram M, Calhau C, Cassano A, Edeas M (2011) Polyphenols and human health: a prospectus. Crit Rev Food Sci Nutr 51:524–546
58. McAllister M (2010) Dynamic dissolution: a step closer to predictive dissolution testing? Mol Pharm 7:1374–1387
59. De Boever P, Wouters R, Vermeirssen V, Boon N, Verstraete W (2001) Development of a six-stage culture system for simulating the gastrointestinal microbiota of weaned infants. Microb Ecol Health Dis 13:111–123
60. Boyer J, Brown D, Liu RH (2005) In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer. Nutr J 4:1