-
1
-
-
84906241583
-
Aging atherosclerosis and the liver sieve
-
Randall LO, ed New York: NOVA Science Publishers
-
Le Couteur DG, Cogger VC, Hilmer SN, et al. Aging, atherosclerosis and the liver sieve. In: Randall LO, ed. Aging and the Elderly: Psychology, Sociology and Health. New York: NOVA Science Publishers; 2006:153-176
-
(2006)
Aging and the Elderly: Psychology, Sociology and Health
, pp. 153-176
-
-
Le Couteur, D.G.1
Cogger, V.C.2
Hilmer, S.N.3
-
2
-
-
0035033142
-
Aging: Overview
-
Harman D. Aging: Overview. Ann N Y Acad Sci. 2001;928:1-21
-
(2001)
Ann N Y Acad Sci
, vol.928
, pp. 1-21
-
-
Harman, D.1
-
3
-
-
0037799701
-
Experimental gerontological research in Australia
-
Andrews GR, Khalil Z, Le Couteur DG. Experimental gerontological research in Australia. Exp Gerontol. 2002;37:1303-1310
-
(2002)
Exp Gerontol
, vol.37
, pp. 1303-1310
-
-
Andrews, G.R.1
Khalil, Z.2
Le Couteur, D.G.3
-
5
-
-
0022609523
-
Aging and the liver
-
Popper H. Aging and the liver. Prog Liver Dis. 1986;8:659-683
-
(1986)
Prog Liver Dis
, vol.8
, pp. 659-683
-
-
Popper, H.1
-
7
-
-
32944468701
-
Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat
-
Hilmer SN, Cogger VC, Fraser R, McLean AJ, Sullivan D, Le Couteur DG. Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology. 2005;42:1349-1354
-
(2005)
Hepatology
, vol.42
, pp. 1349-1354
-
-
Hilmer, S.N.1
Cogger, V.C.2
Fraser, R.3
McLean, A.J.4
Sullivan, D.5
Le Couteur, D.G.6
-
8
-
-
79957813439
-
Age-related pseudocapillarization of the liver sinusoidal endothelium impairs the hepatic clearance of acetaminophen in rats
-
Mitchell SJ, Huizer-Pajkos A, Cogger VC, et al. Age-related pseudocapillarization of the liver sinusoidal endothelium impairs the hepatic clearance of acetaminophen in rats. J Gerontol A Biol Sci Med Sci. 2011;66:400-408
-
(2011)
J Gerontol A Biol Sci Med Sci
, vol.66
, pp. 400-408
-
-
Mitchell, S.J.1
Huizer-Pajkos, A.2
Cogger, V.C.3
-
9
-
-
0032545423
-
Werner syndrome protein II Characterization of the integral 3' - 5' DNA exonuclease
-
Kamath-Loeb AS, Shen JC, Loeb LA, Fry M. Werner syndrome protein. II. Characterization of the integral 3' - 5' DNA exonuclease. J Biol Chem. 1998;273:34145-34150
-
(1998)
J Biol Chem
, vol.273
, pp. 34145-34150
-
-
Kamath-Loeb, A.S.1
Shen, J.C.2
Loeb, L.A.3
Fry, M.4
-
10
-
-
0032545515
-
Werner syndrome protein I DNA helicase and dna exonuclease reside on the same polypeptide
-
Shen JC, Gray MD, Oshima J, Kamath-Loeb AS, Fry M, Loeb LA. Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide. J Biol Chem. 1998;273:34139-34144
-
(1998)
J Biol Chem
, vol.273
, pp. 34139-34144
-
-
Shen, J.C.1
Gray, M.D.2
Oshima, J.3
Kamath-Loeb, A.S.4
Fry, M.5
Loeb, L.A.6
-
11
-
-
0034231844
-
Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest
-
Constantinou A, Tarsounas M, Karow JK, et al. Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest. EMBO Rep. 2000;1:80-84
-
(2000)
EMBO Rep
, vol.1
, pp. 80-84
-
-
Constantinou, A.1
Tarsounas, M.2
Karow, J.K.3
-
12
-
-
2942637828
-
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2
-
Opresko PL, Otterlei M, Graakjaer J, et al. The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. Mol Cell. 2004;14:763-774
-
(2004)
Mol Cell
, vol.14
, pp. 763-774
-
-
Opresko, P.L.1
Otterlei, M.2
Graakjaer, J.3
-
13
-
-
67650523677
-
The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses
-
Turaga RV, Paquet ER, Sild M, et al. The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses. Cell Cycle. 2009;8:2080-2092
-
(2009)
Cell Cycle
, vol.8
, pp. 2080-2092
-
-
Turaga, R.V.1
Paquet, E.R.2
Sild, M.3
-
15
-
-
84875947376
-
Werner syndrome: A changing pattern of clinical manifestations in Japan (1917-2008
-
Goto M, Ishikawa Y, Sugimoto M, Furuichi Y. Werner syndrome: A changing pattern of clinical manifestations in Japan (1917-2008). Biosci Trends. 2013;7(1):13-22
-
(2013)
Biosci Trends
, vol.7
, Issue.1
, pp. 13-22
-
-
Goto, M.1
Ishikawa, Y.2
Sugimoto, M.3
Furuichi, Y.4
-
16
-
-
84869847319
-
Sitagliptin successfully ameliorates glycemic control in Werner syndrome with diabetes
-
Kitamoto T, Takemoto M, Fujimoto M, et al. Sitagliptin successfully ameliorates glycemic control in Werner syndrome with diabetes. Diabetes Care. 2012;35:e83
-
(2012)
Diabetes Care
, vol.35
-
-
Kitamoto, T.1
Takemoto, M.2
Fujimoto, M.3
-
17
-
-
0032573157
-
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
-
Lebel M, Leder P. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci USA. 1998;95:13097-13102
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13097-13102
-
-
Lebel, M.1
Leder, P.2
-
18
-
-
0033978881
-
Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene
-
Wang L, Ogburn CE, Ware CB, et al. Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene. Genetics. 2000;154:357-362
-
(2000)
Genetics
, vol.154
, pp. 357-362
-
-
Wang, L.1
Ogburn, C.E.2
Ware, C.B.3
-
19
-
-
17544402913
-
Mutations in the WRN gene in mice accelerate mortality in a p53-null background
-
Lombard DB, Beard C, Johnson B, et al. Mutations in the WRN gene in mice accelerate mortality in a p53-null background. Mol Cell Biol. 2000;20:3286-3291
-
(2000)
Mol Cell Biol
, vol.20
, pp. 3286-3291
-
-
Lombard, D.B.1
Beard, C.2
Johnson, B.3
-
20
-
-
0242585417
-
Genetic cooperation between the Werner syndrome protein and poly ADPribose (polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice
-
Lebel M, Lavoie J, Gaudreault I, Bronsard M, Drouin R. Genetic cooperation between the Werner syndrome protein and poly(ADPribose (polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice. Am J Pathol. 2003;162:1559-1569
-
(2003)
Am J Pathol
, vol.162
, pp. 1559-1569
-
-
Lebel, M.1
Lavoie, J.2
Gaudreault, I.3
Bronsard, M.4
Drouin, R.5
-
21
-
-
31544474304
-
Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue
-
Massip L, Garand C, Turaga RV, Deschenes F, Thorin E, Lebel M. Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue. Exp Gerontol. 2006;41:157-168
-
(2006)
Exp Gerontol
, vol.41
, pp. 157-168
-
-
Massip, L.1
Garand, C.2
Turaga, R.V.3
Deschenes, F.4
Thorin, E.5
Lebel, M.6
-
22
-
-
79955125211
-
Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome
-
Labbe A, Garand C, Cogger VC, et al. Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome. J Gerontol A Biol Sci Med Sci. 2011;66:264-278
-
(2011)
J Gerontol A Biol Sci Med Sci
, vol.66
, pp. 264-278
-
-
Labbe, A.1
Garand, C.2
Cogger, V.C.3
-
23
-
-
75149172348
-
Vitamin C restores healthy aging in a mouse model for Werner syndrome
-
Massip L, Garand C, Paquet ER, et al. Vitamin C restores healthy aging in a mouse model for Werner syndrome. FASEB J. 2010;24:158-172
-
(2010)
FASEB J
, vol.24
, pp. 158-172
-
-
Massip, L.1
Garand, C.2
Paquet, E.R.3
-
24
-
-
33750333138
-
Hyperlipidemia and surfactants: The liver sieve is a link
-
Cogger VC, Hilmer SN, Sullivan D, Muller M, Fraser R, Le Couteur DG. Hyperlipidemia and surfactants: The liver sieve is a link. Atherosclerosis. 2006;189:273-281
-
(2006)
Atherosclerosis
, vol.189
, pp. 273-281
-
-
Cogger, V.C.1
Hilmer, S.N.2
Sullivan, D.3
Muller, M.4
Fraser, R.5
Le Couteur, D.G.6
-
25
-
-
84881496655
-
Image analysis of liver collagen using sirius red is more accurate and correlates better with serum fibrosis markers than trichrome
-
Huang Y, de Boer WB, Adams LA, et al. Image analysis of liver collagen using sirius red is more accurate and correlates better with serum fibrosis markers than trichrome. Liver Int. 2013;33:1249-1256
-
(2013)
Liver Int
, vol.33
, pp. 1249-1256
-
-
Huang, Y.1
De Boer, W.B.2
Adams, L.A.3
-
26
-
-
84889874203
-
Fenestrations in the liver sinusoidal endothelial cell
-
In: Arias IM Boyer JL eds Hoboken NJ: John Wiley &Sons, Ltd
-
Cogger VC, Le Couteur DG. Fenestrations in the liver sinusoidal endothelial cell. In: Arias IM, Boyer JL, eds. The Liver: Biology and Pathobiology. Hoboken, NJ: John Wiley &Sons, Ltd; 2009, 387-404
-
(2009)
The Liver: Biology and Pathobiology
, pp. 387-404
-
-
Cogger, V.C.1
Le Couteur, D.G.2
-
27
-
-
77955896716
-
Age-related changes in scavenger receptor-mediated endocytosis in rat liver sinusoidal endothelial cells
-
Simon-Santamaria J, Malovic I, Warren A, et al. Age-related changes in scavenger receptor-mediated endocytosis in rat liver sinusoidal endothelial cells. J Gerontol A Biol Sci Med Sci. 2010;65:951-960
-
(2010)
J Gerontol A Biol Sci Med Sci
, vol.65
, pp. 951-960
-
-
Simon-Santamaria, J.1
Malovic, I.2
Warren, A.3
-
28
-
-
79952754268
-
Thiamine prevents obesity and obesity-Associated metabolic disorders in oletf rats
-
Tanaka T, Kono T, Terasaki F, et al. Thiamine prevents obesity and obesity-Associated metabolic disorders in OLETF rats. J Nutr Sci Vitaminol (Tokyo). 2010;56:335-346
-
(2010)
J Nutr Sci Vitaminol (Tokyo
, vol.56
, pp. 335-346
-
-
Tanaka, T.1
Kono, T.2
Terasaki, F.3
-
29
-
-
40649087415
-
Effects of aluminium sulphate in the mouse liver: Similarities to the aging process
-
Stacchiotti A, Lavazza A, Ferroni M, et al. Effects of aluminium sulphate in the mouse liver: Similarities to the aging process. Exp Gerontol. 2008;43:330-338
-
(2008)
Exp Gerontol
, vol.43
, pp. 330-338
-
-
Stacchiotti, A.1
Lavazza, A.2
Ferroni, M.3
-
30
-
-
79952578316
-
Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGFdependent pathway
-
Furrer K, Rickenbacher A, Tian Y, et al. Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGFdependent pathway. Proc Natl Acad Sci USA. 2011;108:2945-2950
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 2945-2950
-
-
Furrer, K.1
Rickenbacher, A.2
Tian, Y.3
-
31
-
-
84856404122
-
A mouse model of accelerated liver aging caused by a defect in DNA repair
-
Gregg SQ, Gutierrez V, Robinson AR, et al. A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology. 2012;55:609-621
-
(2012)
Hepatology
, vol.55
, pp. 609-621
-
-
Gregg, S.Q.1
Gutierrez, V.2
Robinson, A.R.3
-
32
-
-
34447340515
-
Age-related changes in the hepatic microcirculation in mice
-
Ito Y, Sorensen KK, Bethea NW, et al. Age-related changes in the hepatic microcirculation in mice. Exp Gerontol. 2007;42:789-797
-
(2007)
Exp Gerontol
, vol.42
, pp. 789-797
-
-
Ito, Y.1
Sorensen, K.K.2
Bethea, N.W.3
-
33
-
-
0035120774
-
Pseudocapillarization and associated energy limitation in the aged rat liver
-
Le Couteur DG, Cogger VC, Markus AM, et al. Pseudocapillarization and associated energy limitation in the aged rat liver. Hepatology. 2001;33:537-543
-
(2001)
Hepatology
, vol.33
, pp. 537-543
-
-
Le Couteur, D.G.1
Cogger, V.C.2
Markus, A.M.3
-
35
-
-
0036123267
-
Quantifying dense bodies and lipofuscin During aging: A morphologist's perspective
-
Schmucker DL, Sachs H. Quantifying dense bodies and lipofuscin During aging: A morphologist's perspective. Arch Gerontol Geriatr. 2002;34:249-261
-
(2002)
Arch Gerontol Geriatr
, vol.34
, pp. 249-261
-
-
Schmucker, D.L.1
Sachs, H.2
-
36
-
-
6144240312
-
An electron microscope study of age changes in the liver of the mouse
-
Andrew W. An electron microscope study of age changes in the liver of the mouse. Am J Anat. 1962;110:1-18
-
(1962)
Am J Anat
, vol.110
, pp. 1-18
-
-
Andrew, W.1
-
37
-
-
84919874871
-
The aging liver and longterm caloric restriction
-
In: Everitt AV Rattan SIS Couteur DG Cabo R eds Springer Press
-
Le Couteur DG, Sinclair DA, Cogger VC, et al. The aging liver and longterm caloric restriction. In: Everitt AV, Rattan SIS, Couteur DG, Cabo R, eds. Calorie Restriction, Aging and Longevity. Dordrecht, Netherlands; Springer Press; 2010:191-216
-
(2010)
Calorie Restriction Aging and Longevity. Dordrecht Netherlands
, pp. 191-216
-
-
Le Couteur, D.G.1
Sinclair, D.A.2
Cogger, V.C.3
-
38
-
-
0026554863
-
Counting target molecules by exponential polymerase chain reaction: Copy number of mitochondrial DNA in rat tissues
-
Wiesner RJ, Ruegg JC, Morano I. Counting target molecules by exponential polymerase chain reaction: Copy number of mitochondrial DNA in rat tissues. Biochem Biophys Res Commun. 1992;183:553-559
-
(1992)
Biochem Biophys Res Commun
, vol.183
, pp. 553-559
-
-
Wiesner, R.J.1
Ruegg, J.C.2
Morano, I.3
-
39
-
-
0021721747
-
Euploidization of human hepatocytes from donors of different ages and both sexes compared with those from cases of Werner's syndrome and progeria
-
Gahan PB, Middleton J. Euploidization of human hepatocytes from donors of different ages and both sexes compared with those from cases of Werner's syndrome and progeria. Exp Gerontol. 1984;19:355-358
-
(1984)
Exp Gerontol
, vol.19
, pp. 355-358
-
-
Gahan, P.B.1
Middleton, J.2
-
40
-
-
80052056533
-
Loss of PDGF-B activity increases hepatic vascular permeability and enhances insulin sensitivity
-
Raines SM, Richards OC, Schneider LR, et al. Loss of PDGF-B activity increases hepatic vascular permeability and enhances insulin sensitivity. Am J Physiol Endocrinol Metab. 2011;301:E517-E526
-
(2011)
Am J Physiol Endocrinol Metab
, vol.301
-
-
Raines, S.M.1
Richards, O.C.2
Schneider, L.R.3
-
41
-
-
84859735442
-
SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling
-
Palty R, Raveh A, Kaminsky I, Meller R, Reuveny E. SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling. Cell. 2012;149:425-438
-
(2012)
Cell
, vol.149
, pp. 425-438
-
-
Palty, R.1
Raveh, A.2
Kaminsky, I.3
Meller, R.4
Reuveny, E.5
-
42
-
-
65649116886
-
Ubiquitin-mediated proteolysis of HuR by heat shock
-
Abdelmohsen K, Srikantan S, Yang X, et al. Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J. 2009;28:1271-1282
-
(2009)
EMBO J
, vol.28
, pp. 1271-1282
-
-
Abdelmohsen, K.1
Srikantan, S.2
Yang, X.3
-
43
-
-
58049193005
-
Conserved domains of the class A scavenger receptors: Evolution and function
-
Bowdish DM, Gordon S. Conserved domains of the class A scavenger receptors: Evolution and function. Immunol Rev. 2009;227:19-31
-
(2009)
Immunol Rev
, vol.227
, pp. 19-31
-
-
Bowdish, D.M.1
Gordon, S.2
-
44
-
-
84859081972
-
Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells
-
Bieghs V, Verheyen F, van Gorp PJ, et al. Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. PLoS One. 2012;7:e34378
-
(2012)
PLoS One
, vol.7
-
-
Bieghs, V.1
Verheyen, F.2
Van Gorp, P.J.3
-
45
-
-
3442882851
-
Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells
-
Gonzalez M, Flores C, Pearson JD, Casanello P, Sobrevia L. Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells. Pflugers Arch. 2004;448:383-394
-
(2004)
Pflugers Arch
, vol.448
, pp. 383-394
-
-
Gonzalez, M.1
Flores, C.2
Pearson, J.D.3
Casanello, P.4
Sobrevia, L.5
-
46
-
-
33747893889
-
Pathology and nuclear abnormalities in hearts of transgenic mice expressing m371k lamin a encoded by an lmna mutation causing emery-dreifuss muscular dystrophy
-
Wang Y, Herron AJ, Worman HJ. Pathology and nuclear abnormalities in hearts of transgenic mice expressing M371K lamin A encoded by an LMNA mutation causing Emery-Dreifuss muscular dystrophy. Hum Mol Genet. 2006;15:2479-2489
-
(2006)
Hum Mol Genet
, vol.15
, pp. 2479-2489
-
-
Wang, Y.1
Herron, A.J.2
Worman, H.J.3
-
47
-
-
26444595257
-
Expression of an LMNA-N195K variant of A-Type lamins results in cardiac conduction Defects and death in mice
-
Mounkes LC, Kozlov SV, Rottman JN, Stewart CL. Expression of an LMNA-N195K variant of A-Type lamins results in cardiac conduction Defects and death in mice. Hum Mol Genet. 2005;14:2167-2180
-
(2005)
Hum Mol Genet
, vol.14
, pp. 2167-2180
-
-
Mounkes, L.C.1
Kozlov, S.V.2
Rottman, J.N.3
Stewart, C.L.4
-
48
-
-
0033615969
-
Loss of A-Type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy
-
Sullivan T, Escalante-Alcalde D, Bhatt H, et al. Loss of A-Type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. J Cell Biol. 1999;147:913-920
-
(1999)
J Cell Biol
, vol.147
, pp. 913-920
-
-
Sullivan, T.1
Escalante-Alcalde, D.2
Bhatt, H.3
-
49
-
-
19944426537
-
Mouse model carrying H222P-Lmna mutation Develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies
-
Arimura T, Helbling-Leclerc A, Massart C, et al. Mouse model carrying H222P-Lmna mutation Develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies. Hum Mol Genet. 2005;14:155-169
-
(2005)
Hum Mol Genet
, vol.14
, pp. 155-169
-
-
Arimura, T.1
Helbling-Leclerc, A.2
Massart, C.3
-
50
-
-
1942469525
-
Novel lamin A/C gene (LMNA) mutations in atypical progeroid syndromes
-
Csoka AB, Cao H, Sammak PJ, Constantinescu D, Schatten GP, Hegele RA. Novel lamin A/C gene (LMNA) mutations in atypical progeroid syndromes. J Med Genet. 2004;41:304-308
-
(2004)
J Med Genet
, vol.41
, pp. 304-308
-
-
Csoka, A.B.1
Cao, H.2
Sammak, P.J.3
Constantinescu, D.4
Schatten, G.P.5
Hegele, R.A.6
|