Thiamine prevents obesity and obesity-associated metabolic disorders in OLETF rats

Journal of Nutritional Science and Vitaminology

Volumn 56, Issue 6, 2010, Pages 335-346

  Tanaka, Takao ^a   Kono, Tatsuji ^a   Fumio, Terasaki ^a   Yasui, Kota ^a   Soyama, Akiko ^a   Otsuka, Kaoru ^a   Fujita, Shuichi ^a   Yamane, Kazuhiko ^a   Manabe, Miki ^a   Usui, Kazuya ^a   Kohda, Yuka ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Metabolic syndrome; Obesity; Oletf rats; Thiamine

Indexed keywords

CHOLESTEROL; ENTACTIN; FATTY ACID; GLUCOSE; HEMOGLOBIN A1C; INSULIN; KETONE; LAMININ; LAMININ BETA1; MESSENGER RNA; NIDOGEN 1; PYRUVATE DEHYDROGENASE; THIAMINE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; BODY WEIGHT; CARDIOVASCULAR PARAMETERS; CELL INFILTRATION; CELL SIZE; CONTROLLED STUDY; DRUG EFFECT; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; FATTY LIVER; FIBROSIS; GENE EXPRESSION; GLOMERULOPATHY; HEART FUNCTION; HEART MUSCLE FIBROSIS; HISTOPATHOLOGY; KIDNEY FIBROSIS; LIPID PEROXIDATION; MALE; METABOLIC DISORDER; METABOLIC PARAMETERS; MONONUCLEAR CELL; MYOFIBROSIS; NONHUMAN; OBESITY; ORGAN WEIGHT; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; PANCREAS DISEASE; PSEUDOCAPILLARIZATION; RAT; SKELETAL MUSCLE;

ADIPOCYTES; ANIMALS; BASEMENT MEMBRANE; BLOOD VESSELS; FIBROSIS; KIDNEY; LAMININ; LEUKOCYTES, MONONUCLEAR; LIPID PEROXIDATION; LIVER; MALE; MEMBRANE GLYCOPROTEINS; METABOLIC DISEASES; MUSCLE, SKELETAL; MYOCARDIUM; OBESITY; OXIDOREDUCTASES; PANCREAS; RATS; RATS, INBRED OLETF; RNA; THIAMINE; VITAMIN B COMPLEX;

RATTUS;

EID: 79952754268     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.56.335     Document Type: Article

References (41)

1. Moller DE, Kaufman KD. 2005. Metabolic syndrome: a clinical and molecular perspective. Annu Rev Med 56: 45-62.
2. WHO. 2000. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 894: 1-253.
3. Babaei-Jadidi R, Karachalias N, Ahmed N, Battah S, Thornalley PJ. 2003. Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Diabetes 52: 2110-2120.
4. Brownlee M. 2001. Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820.
5. Ceylan-Isik AF, Wu S, Li Q, Li SY, Ren J. 2006. High-dose benfotiamine rescues cardiomyocyte contractile dysfunction in streptozotocin-induced diabetes mellitus. J Appl Physiol 100: 150-156.
6. Hammes HP, Du X, Edelstein D, Taguchi T, Matsumura T, Ju Q, Lin J, Bierhaus A, Nawroth P, Hannak D, Neumaier M, Bergfeld R, Giardino I, Brownlee M. 2003. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med 9: 294-299.
7. Kohda Y, Shirakawa H, Yamane K, Otsuka K, Kono T, Terasaki F, Tanaka T. 2008. Prevention of incipient diabetic cardiomyopathy by high-dose thiamine. J Toxicol Sci 33: 459-472.
8. Stirban A, Negrean M, Stratmann B, Gawlowski T, Horstmann T, Götting C, Kleesiek K, Mueller-Roesel M, Koschinsky T, Uribarri J, Vlassara H, Tschoepe D. 2006. Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. Diabetes Care 29: 2064-2071.
9. Stracke H, Hammes HP, Werkmann D, Mavrakis K, Bitsch I, Netzel M, Geyer J, Köpcke W, Sauerland C, Bretzel RG, Federlin KF. 2001. Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. Exp Clin Endocrinol Diabetes 109: 330-336.
10. Stracke H, Lindemann A, Federlin KF. 1996. A benfotiamine- vitamin B combination in treatment of diabetic polyneuropathy. Exp Clin Endocrinol Diabetes 104: 311-316.
11. Abboud MR, Alexander D, Najjar SS. 1985. Diabetes mellitus, thiamine-dependent megaloblastic anemia, and sensorineural deafness associated with deficient - ketoglutarate dehydrogenase activity. J Pediatr 107: 537-541.
12. Alzahrani A, Baitei E, Zou M, Shi Y. 2006. Thiamine transporter mutation: an example of monogenic diabetes mellitus. Eur J Endocrinol 155: 787-792.
13. Borgna-Pignatti C, Marradi P, Pinelli L, Monetti N, Patrini C. 1989. Thiamine-responsive anemia in DIDMOAD syndrome. J Pediatr 114: 405-410.
14. Neufeld EJ, Fleming JC, Tartaglini E, Steinkamp MP. 2001. Thiamine-responsive megaloblastic anemia syndrome: a disorder of high-affinity thiamine transport. Blood Cells Mol Dis 27: 135-138.
15. Elbein SC, Hoffman MD, Teng K, Leppert MF, Hasstedt SJ. 1999. A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians. Diabetes 48: 1175-1182.
16. Hanson RL, Ehm MG, Pettitt DJ, Prochazka M, Thompson DB, Timberlake D, Foroud T, Kobes S, Baier L, Burns DK, Almasy L, Blangero J, Garvey WT, Bennett PH, Knowler WC. 1998. An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians. Am J Hum Genet 63: 1130-1138.
17. Thornalley PJ, Babaei-Jadidi R, Al Ali H, Rabbani N, Antonysunil A, Larkin J, Ahmed A, Rayman G, Bodmer CW. 2007. High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia 50: 2164-2170.
18. Valerio G, Franzese A, Poggi V, Patrini C, Laforenza U, Tenore A. 1999. Lipophilic thiamine treatment in longstanding insulin-dependent diabetes mellitus. Acta Diabetol 36: 73-76.
19. Aitman TJ, Gotoda T, Evans AL, Imrie H, Heath KE, Trembling PM, Truman H, Wallace CA, Rahman A, Doré C, Flint J, Kren V, Zidek V, Kurtz TW, Pravenec M, Scott J. 1997. Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats. Nat Genet 16: 197-201.
20. Aitman TJ, Glazier AM, Wallace CA, Cooper LD, Norsworthy PJ, Wahid FN, Al-Majali KM, Trembling PM, Mann CJ, Shoulders CC, Graf D, St-Lezin E, Kurtz TW, Kren V, Pravenec M, Ibrahimi A, Abumrad NA, Stanton LW, Scott J. 1999. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet 21: 76-83.
21. Tanaka T, Sohmiya K, Kono T, Terasaki F, Horie R, Ohkaru Y, Muramatsu M, Takai S, Miyazaki M, Kitaura Y. 2007. Thiamine attenuates the hypertension and metabolic abnormalities in CD36-defective SHR: uncoupling of glucose oxidation from cellular entry accompanied with enhanced protein O-GlcNAcylation in CD36 deficiency. Mol Cell Biochem 299: 23-35.
22. Bligh EG, Dyer WJ. 1959. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911-917.
23. Dobbins RL, Szczepaniak LS, Bentley B, Esser V, Myhill J, McGarry JD. 2001. Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats. Diabetes 50: 123-130.
24. Sterk JP, Stanley WC, Hoppel CL, Kerner J. 2003. A radiochemical pyruvate dehydrogenase assay: activity in heart. Anal Biochem 313: 179-182.
25. Pi-Sunyer FX. 1976. Resistance to ketosis during prolonged fasting by rats fed on a diet containing undecanoic acid, an odd-carbon-number fatty acid. Br J Nutr 35: 41-46.
26. Kim JY, Hickner RC, Cortright RL, Dohm GL, Houmard JA. 2000. Lipid oxidation is reduced in obese human skeletal muscle. Am J Physiol Endocrinol Metab 279: E1039-E1044.
27. Zurlo F, Lillioja S, Esposito-Del Puente A, Nyomba BL, Raz I, Saad MF, Swinburn BA, Knowler WC, Bogardus C, Ravussin E. 1990. Low ratio of fat to carbohydrate oxidation as predictor of weight gain: study of 24-h RQ. Am J Physiol 259: E650-E657.
28. Pasarica M, Tchoukalova YD, Heilbronn LK, Fang X, Albu JB, Kelley DE, Smith SR, Ravussin E; Look AHEAD Adipose Research Group. 2009. Differential effect of weight loss on adipocyte size subfractions in patients with type 2 diabetes. Obesity (Silver Spring) 17: 1976-1978.
29. Fujita A, Sasaki H, Doi A, Okamoto K, Matsuno S, Furuta H, Nishi M, Nakao T, Tsuno T, Taniguchi H, Nanjo K. 2008. Ferulic acid prevents pathological and functional abnormalities of the kidney in Otsuka Long- Evans Tokushima Fatty diabetic rats. Diabetes Res Clin Pract 79: 11-17.
30. Matsuda S, Iwata K, Takahashi K, Homma H, Tamura Y, Kanda Y, Inokami T, Nosaka H, Nagase M, Uchida S. 2004. A low-protein diet concomitant with high calorie intake preserves renal function and structure in diabetic OLETF rats. Clin Exp Nephrol 8: 322-330.
31. Lee Y, Naseem RH, Park BH, Garry DJ, Richardson JA, Schaffer JE, Unger RH. 2006. -Lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice. Biochem Biophys Res Commun 344: 446-452.
32. Zhou YT, Grayburn P, Karim A, Shimabukuro M, Higa M, Baetens D, Orci L, Unger RH. 2000. Lipotoxic heart disease in obese rats: implications for human obesity. Proc Natl Acad Sci USA 97: 1784-1789.
33. Szczepaniak LS, Dobbins RL, Metzger GJ, Sartoni- D'Ambrosia G, Arbique D, Vongpatanasin W, Unger R, Victor RG. 2003. Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging. Magn Reson Med 49: 417-423.
34. Le Couteur DG, Fraser R, Cogger VC, McLean AJ. 2002. Hepatic pseudocapillarisation and atherosclerosis in ageing. Lancet 359: 1612-1615.
35. Harrison SA, Brunt EM, Goodman ZD, Di Bisceglie AM. 2006. Diabetic hepatosclerosis: diabetic microangiopathy of the liver. Arch Pathol Lab Med 130: 27-32.
36. Bernuau D, Guillot R, Durand-Schneider AM, Poussier P, Moreau A, Feldmann G. 1985. Liver perisinusoidal fibrosis in BB rats with or without overt diabetes. Am J Pathol 120: 38-45.
37. Aumailley M, Battaglia C, Mayer U, Reinhardt D, Nischt R, Timpl R, Fox JW. 1993. Nidogen mediates the formation of ternary complexes of basement membrane components. Kidney Int 43: 7-12.
38. Kohfeldt E, Sasaki T, Göhring W, Timpl R. 1998. Nidogen-2: a new basement membrane protein with diverse binding properties. J Mol Biol 282: 99-109.
39. Bajotto G, Murakami T, Nagasaki M, Tamura T, Tamura N, Harris RA, Shimomura Y, Sato Y. 2004. Downregulation of the skeletal muscle pyruvate dehydrogenase complex in the Otsuka Long-Evans Tokushima Fatty rat both before and after the onset of diabetes mellitus. Life Sci 75: 2117-2130.
40. Curto M, Novi RF, Rabbone I, Maurino M, Piccinini M, Mioletti S, Mostert M, Bruno R, Rinaudo MT. 1997. Insulin resistance in obese subjects and newly diagnosed NIDDM patients and derangements of pyruvate dehydrogenase in their circulating lymphocytes. Int J Obes Relat Metab Disord 21: 1137-1142.
41. Liu S, Manson JE. 2001. Dietary carbohydrates, physical inactivity, obesity, and the 'metabolic syndrome' as predictors of coronary heart disease. Curr Opin Lipidol 12: 395-404.