Age-related pseudocapillarization of the liver sinusoidal endothelium impairs the hepatic clearance of acetaminophen in rats

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 66 A, Issue 4, 2011, Pages 400-408

  Mitchell, Sarah J ^a,b   Huizer Pajkos, Aniko ^a   Cogger, Victoria C ^b,c   McLachlan, Andrew J ^c   Le Couteur, David G ^b,c   Jones, Brett ^a   De Cabo, Rafael ^d   Hilmer, Sarah N ^a,b  

^a ROYAL NORTH SHORE HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Acetaminophen; Aging; Extraction; Isolated liver perfusion; Pseudocapillarization

Indexed keywords

RATTUS;

ANALGESIC AGENT; ANTIPYRETIC AGENT; PARACETAMOL;

AGING; ANIMAL; ARTICLE; ENDOTHELIUM; FISCHER 344 RAT; INDICATOR DILUTION CURVE; LIVER; MALE; METABOLISM; RAT; SCANNING ELECTRON MICROSCOPY; ULTRASTRUCTURE; VASCULARIZATION;

ACETAMINOPHEN; AGING; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTIPYRETICS; ENDOTHELIUM; INDICATOR DILUTION TECHNIQUES; LIVER; MALE; MICROSCOPY, ELECTRON, SCANNING; RATS; RATS, INBRED F344;

EID: 79957813439     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glq221     Document Type: Article

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