메뉴 건너뛰기




Volumn 7, Issue 1, 2013, Pages 13-22

Werner syndrome: A changing pattern of clinical manifestations: In Japan (1917~2008)

Author keywords

Aging; Cancer prone syndrome; Helicase; Inflammation; Longevity; Premature aging; Werner syndrome

Indexed keywords

EXODEOXYRIBONUCLEASE; RECQ HELICASE; WRN PROTEIN, HUMAN;

EID: 84875947376     PISSN: 18817815     EISSN: 18817823     Source Type: Journal    
DOI: 10.5582/bst.2013.v7.1.13     Document Type: Review
Times cited : (77)

References (76)
  • 1
    • 0026502062 scopus 로고
    • Genetic linkage of Werner's syndrome to five markers on chromosome 8
    • Goto M, Rubenstein M, Weber J, Woods K, Drayna D. Genetic linkage of Werner's syndrome to five markers on chromosome 8. Nature. 1992; 355:735-738.
    • (1992) Nature , vol.355 , pp. 735-738
    • Goto, M.1    Rubenstein, M.2    Weber, J.3    Woods, K.4    Drayna, D.5
  • 4
    • 0030691121 scopus 로고    scopus 로고
    • Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing
    • Goto M. Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing. Mech Age Dev. 1997; 98:239-254.
    • (1997) Mech Age Dev , vol.98 , pp. 239-254
    • Goto, M.1
  • 5
    • 0013907774 scopus 로고
    • Werner's syndrome. A review of its symptomatology, natural history, pathologic features, genetics and relationship to natural aging process
    • Epstein CJ, Martin GM, Schultz AG, Motulsky AG. Werner's syndrome. A review of its symptomatology, natural history, pathologic features, genetics and relationship to natural aging process. Medicine (Baltimore). 1966; 45:177-221.
    • (1966) Medicine (Baltimore) , vol.45 , pp. 177-221
    • Epstein, C.J.1    Martin, G.M.2    Schultz, A.G.3    Motulsky, A.G.4
  • 6
    • 0017840139 scopus 로고
    • Genetic syndrome in man with potential relevance to the pathobiology of aging
    • Martin GM. Genetic syndrome in man with potential relevance to the pathobiology of aging. Birth Defects Orig Article Ser. 1978; 14:5-39.
    • (1978) Birth Defects Orig Article Ser , vol.14 , pp. 5-39
    • Martin, G.M.1
  • 7
    • 0022330944 scopus 로고
    • Genetics and aging: the Werner syndrome as a segmental progeroid syndrome
    • Martin GM. Genetics and aging: the Werner syndrome as a segmental progeroid syndrome. Adv Exp Med Biol. 1985; 190:161-170.
    • (1985) Adv Exp Med Biol , vol.190 , pp. 161-170
    • Martin, G.M.1
  • 10
    • 0031204917 scopus 로고    scopus 로고
    • Impaired nuclear localization of defective DNA helicases in Werner's syndrome
    • Matsumoto T, Shimamoto A, Goto M, Furuichi Y. Impaired nuclear localization of defective DNA helicases in Werner's syndrome. Nat Genet. 1997; 16:335-336.
    • (1997) Nat Genet , vol.16 , pp. 335-336
    • Matsumoto, T.1    Shimamoto, A.2    Goto, M.3    Furuichi, Y.4
  • 12
    • 77952315909 scopus 로고    scopus 로고
    • Secular trends towards delayed onsets of pathologies and prolonged longevities in Japanese patients with Werner syndrome
    • Goto M, Matsuura M. Secular trends towards delayed onsets of pathologies and prolonged longevities in Japanese patients with Werner syndrome. BioSci Trends. 2008; 2:81-87.
    • (2008) BioSci Trends , vol.2 , pp. 81-87
    • Goto, M.1    Matsuura, M.2
  • 13
    • 77952312948 scopus 로고    scopus 로고
    • An international effort to cure premature ageing
    • Faragher R, Goto M. An international effort to cure premature ageing. BioSci Trends. 2007; 1:66-67.
    • (2007) BioSci Trends , vol.1 , pp. 66-67
    • Faragher, R.1    Goto, M.2
  • 14
    • 0019507754 scopus 로고
    • Family analysis of Werner's syndrome: A survey of 42 Japanese families with a review of the literature
    • Goto M, Tanimoto K, Horiuchi Y, Sasazuki T. Family analysis of Werner's syndrome: A survey of 42 Japanese families with a review of the literature. Clin Genet. 1981; 19:8-15.
    • (1981) Clin Genet , vol.19 , pp. 8-15
    • Goto, M.1    Tanimoto, K.2    Horiuchi, Y.3    Sasazuki, T.4
  • 15
    • 0034797868 scopus 로고    scopus 로고
    • Clinical characteristics of Werner syndrome and other premature aging syndromes: Pattern of aging in progeroid syndromes
    • Gann Monograph on Cancer Research No.49. (Goto M, Miller RW, eds.). Karger, Tokyo, Japan
    • Goto M. Clinical characteristics of Werner syndrome and other premature aging syndromes: Pattern of aging in progeroid syndromes. In: From premature gray hair to helicase-Werner syndrome:Implications for aging and cancer. Gann Monograph on Cancer Research No.49. (Goto M, Miller RW, eds.). Karger, Tokyo, Japan, 2001; pp.27-39.
    • (2001) From premature gray hair to helicase-Werner syndrome:Implications for aging and cancer , pp. 27-39
    • Goto, M.1
  • 16
    • 0001182428 scopus 로고    scopus 로고
    • Genetic diagnosis of Werner's syndrome, a premature aging disease, by mutant allele specific amplification (MASA) and oligomer ligation assay (OLA)
    • Matsumoto T, Tsuchihashi Z, Ito C, Fujita K, Goto M, Furuichi Y. Genetic diagnosis of Werner's syndrome, a premature aging disease, by mutant allele specific amplification (MASA) and oligomer ligation assay (OLA). J Anti-Aging Med. 1998; 1:131-140.
    • (1998) J Anti-Aging Med , vol.1 , pp. 131-140
    • Matsumoto, T.1    Tsuchihashi, Z.2    Ito, C.3    Fujita, K.4    Goto, M.5    Furuichi, Y.6
  • 18
    • 51249195723 scopus 로고
    • On cataract in conjunction with a characteristic skin degeneration
    • Rothmund A. On cataract in conjunction with a characteristic skin degeneration. Graefes Arch Ophthal. 1868; 14:159-182.
    • (1868) Graefes Arch Ophthal , vol.14 , pp. 159-182
    • Rothmund, A.1
  • 19
    • 0001743196 scopus 로고
    • An hitherto undescribed familial disease
    • Thomson MS. An hitherto undescribed familial disease. Br J Dermatol. 1923; 35:455-462.
    • (1923) Br J Dermatol , vol.35 , pp. 455-462
    • Thomson, M.S.1
  • 20
    • 0001078903 scopus 로고
    • Werner's syndrome (progeria of the adult) and Rothmund's syndrome; 2 types of closely related heredofamilial atrophic dermatoses; critical study with 5 new cases
    • Thannhauser SJ. Werner's syndrome (progeria of the adult) and Rothmund's syndrome; 2 types of closely related heredofamilial atrophic dermatoses; critical study with 5 new cases. Ann Intern Med. 1945; 23:559-626.
    • (1945) Ann Intern Med , vol.23 , pp. 559-626
    • Thannhauser, S.J.1
  • 22
    • 0343347966 scopus 로고
    • A case of cataract associated with scleroderma
    • in Japanese
    • Ishida R. A case of cataract associated with scleroderma. Jpn J Ophthalmol. 1917; 21:1025-1032. (in Japanese).
    • (1917) Jpn J Ophthalmol , vol.21 , pp. 1025-1032
    • Ishida, R.1
  • 24
    • 0001026233 scopus 로고
    • Werner's syndrome: a heredofamilial disorder with scleroderma, bilateral juvenile cataract, precocious graying of hair and endocrine stigmatization
    • Oppenheimer BS, Kugel VH. Werner's syndrome: a heredofamilial disorder with scleroderma, bilateral juvenile cataract, precocious graying of hair and endocrine stigmatization. Trans Assoc Am Physicians. 1934; 49:358-370.
    • (1934) Trans Assoc Am Physicians , vol.49 , pp. 358-370
    • Oppenheimer, B.S.1    Kugel, V.H.2
  • 25
    • 0000587017 scopus 로고
    • Werner's syndrome, report of the first necropsy and findings in a new case
    • Oppenheimer BS, Kugel VH. Werner's syndrome, report of the first necropsy and findings in a new case. Am J Med Sci. 1941; 202:629-642.
    • (1941) Am J Med Sci , vol.202 , pp. 629-642
    • Oppenheimer, B.S.1    Kugel, V.H.2
  • 26
    • 0013461197 scopus 로고
    • Precocious cataracts and scleroderma (Rothmund's syndrome: Werner's syndrome)
    • Agatson SA, Gartner G. Precocious cataracts and scleroderma (Rothmund's syndrome: Werner's syndrome). Arch Ophthalmol. 1939; 21:492-496.
    • (1939) Arch Ophthalmol , vol.21 , pp. 492-496
    • Agatson, S.A.1    Gartner, G.2
  • 27
    • 84875966509 scopus 로고
    • Werner's syndrome: Report of a case with post-mortem findings
    • in Japanese
    • Hamada Y. Werner's syndrome: Report of a case with post-mortem findings. Jpn J Clin Dermatol Urol. 1966; 20:61-65. (in Japanese).
    • (1966) Jpn J Clin Dermatol Urol , vol.20 , pp. 61-65
    • Hamada, Y.1
  • 28
    • 0342912735 scopus 로고
    • Werner's syndrome associated with malignant melanoma
    • in Japanese
    • Koga M. Werner's syndrome associated with malignant melanoma. Jpn J Clin Dermatol Urol. 1968; 22:1160-1161. (in Japanese).
    • (1968) Jpn J Clin Dermatol Urol , vol.22 , pp. 1160-1161
    • Koga, M.1
  • 29
    • 0024372470 scopus 로고
    • Osteosclerosis of the phalanges in Werner syndrome
    • Goto M, Kindynis P, Resnick D, Sartoris DJ. Osteosclerosis of the phalanges in Werner syndrome. Radiology. 1989; 172:841-843.
    • (1989) Radiology , vol.172 , pp. 841-843
    • Goto, M.1    Kindynis, P.2    Resnick, D.3    Sartoris, D.J.4
  • 30
    • 0031752471 scopus 로고    scopus 로고
    • Bone and calcium metabolism in Werner's syndrome
    • Shiraki M, Aoki C, Goto M. Bone and calcium metabolism in Werner's syndrome. Endocr J. 1998; 45:505-512.
    • (1998) Endocr J , vol.45 , pp. 505-512
    • Shiraki, M.1    Aoki, C.2    Goto, M.3
  • 32
    • 0018119113 scopus 로고
    • Werner's syndrome: Analysis of 15 cases with a review of the Japanese literature
    • Goto M, Horiuchi Y, Tanimoto K, Ishii T, Nakashima H. Werner's syndrome: Analysis of 15 cases with a review of the Japanese literature. J Am Geriatr Soc. 1978; 26:341-347.
    • (1978) J Am Geriatr Soc , vol.26 , pp. 341-347
    • Goto, M.1    Horiuchi, Y.2    Tanimoto, K.3    Ishii, T.4    Nakashima, H.5
  • 33
    • 4444242631 scopus 로고    scopus 로고
    • Metabolic improvement and abdominal fat redistribution in Werner syndrome by pioglitazone
    • Yokote K, Honjo S, Kobayashi K, Kawamura H, Mori S, Saito Y. Metabolic improvement and abdominal fat redistribution in Werner syndrome by pioglitazone. J Am Geriatr Soc. 2004; 52:1582-1583.
    • (2004) J Am Geriatr Soc , vol.52 , pp. 1582-1583
    • Yokote, K.1    Honjo, S.2    Kobayashi, K.3    Kawamura, H.4    Mori, S.5    Saito, Y.6
  • 35
    • 0034793686 scopus 로고    scopus 로고
    • Dermatological features and collagen metabolism in Werner syndrome
    • Gann monograph on Cancer research No.49. (Goto M, Miller RW. Eds.). Karger, Tokyo, Japan
    • Hatamochi A. Dermatological features and collagen metabolism in Werner syndrome. In: From premature gray hair to helicase-Werner syndrome:Implications for aging and cancer. Gann monograph on Cancer research No.49. (Goto M, Miller RW. Eds.). Karger, Tokyo, Japan. 2001; pp. 51-59.
    • (2001) From premature gray hair to helicase-Werner syndrome:Implications for aging and cancer , pp. 51-59
    • Hatamochi, A.1
  • 37
    • 0028914663 scopus 로고
    • Hypercoagulable state indicates an additional risk factor for atherosclerosis in Werner's syndrome
    • Goto M, Kato Y. Hypercoagulable state indicates an additional risk factor for atherosclerosis in Werner's syndrome. Thromb Haemost. 1995; 73:576-578.
    • (1995) Thromb Haemost , vol.73 , pp. 576-578
    • Goto, M.1    Kato, Y.2
  • 38
    • 4644328933 scopus 로고    scopus 로고
    • Dysadiponectinemia in Werner syndrome and its recovery by treatment with pioglitazone
    • Yokote K, Hara K, Mori S, Kadowaki T, Saito Y, Goto M. Dysadiponectinemia in Werner syndrome and its recovery by treatment with pioglitazone. Diabetes Care. 2004; 27:2562-2563.
    • (2004) Diabetes Care , vol.27 , pp. 2562-2563
    • Yokote, K.1    Hara, K.2    Mori, S.3    Kadowaki, T.4    Saito, Y.5    Goto, M.6
  • 42
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in athrosclerosis
    • Libby P. Inflammation in athrosclerosis. Nature. 2002; 420:868-874.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 43
    • 84875946128 scopus 로고    scopus 로고
    • Mild atherosclerosis in an autopsy case of Werner syndrome
    • in Japanese
    • Mori S, Yokote K, Kondo Y, Murano S, Saito Y. Mild atherosclerosis in an autopsy case of Werner syndrome. Aging Dis. 1999; 12:742-745. (in Japanese).
    • (1999) Aging Dis , vol.12 , pp. 742-745
    • Mori, S.1    Yokote, K.2    Kondo, Y.3    Murano, S.4    Saito, Y.5
  • 45
    • 0017800398 scopus 로고
    • Urinary excretion of macromolecular acidic glycosaminoglycans in Werner's syndrome
    • Goto M, Murata K. Urinary excretion of macromolecular acidic glycosaminoglycans in Werner's syndrome. Clin Chim Acta. 1978; 85:101-106.
    • (1978) Clin Chim Acta , vol.85 , pp. 101-106
    • Goto, M.1    Murata, K.2
  • 46
    • 0033127991 scopus 로고    scopus 로고
    • A competitive enzyme-linked immunosorbent assay like method for the detection of urinary hyaluronan
    • Maeda H, Fujita H, Sakura Y, Miyazaki K, Goto M. A competitive enzyme-linked immunosorbent assay like method for the detection of urinary hyaluronan. Biosci Biotechnol Biochem. 1999; 63:892-895.
    • (1999) Biosci Biotechnol Biochem , vol.63 , pp. 892-895
    • Maeda, H.1    Fujita, H.2    Sakura, Y.3    Miyazaki, K.4    Goto, M.5
  • 47
    • 0035090172 scopus 로고    scopus 로고
    • Elevation of serum hyaluronan level in Werner's syndrome
    • Tanabe M, Goto M. Elevation of serum hyaluronan level in Werner's syndrome. Gerontology. 2001; 47:77-81.
    • (2001) Gerontology , vol.47 , pp. 77-81
    • Tanabe, M.1    Goto, M.2
  • 48
    • 0029973179 scopus 로고    scopus 로고
    • Serum hyaluronan as a disease marker
    • Laurent TC. Serum hyaluronan as a disease marker. Ann Med. 1996; 28:241-253.
    • (1996) Ann Med , vol.28 , pp. 241-253
    • Laurent, T.C.1
  • 49
    • 0024205596 scopus 로고
    • The diurnal variation of serum hyaluronan in health and disease
    • Lindquvist U. The diurnal variation of serum hyaluronan in health and disease. Scand J Clin Lab Invest. 1988; 48:765-770.
    • (1988) Scand J Clin Lab Invest , vol.48 , pp. 765-770
    • Lindquvist, U.1
  • 50
    • 0033501681 scopus 로고    scopus 로고
    • Serum levels of hyaluronan, antigenic keratin sulfate, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 change predictably in rheumatoid arthritis patients who have begun activity after a night of bed rest
    • Manicourt DH, Poilvache P, Nzeusseu A, van Egeren A, Devogelaer JP, Lenz ME, Thonar EJ. Serum levels of hyaluronan, antigenic keratin sulfate, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 change predictably in rheumatoid arthritis patients who have begun activity after a night of bed rest. Arthritis Rheum. 1999; 42:1861-1869.
    • (1999) Arthritis Rheum , vol.42 , pp. 1861-1869
    • Manicourt, D.H.1    Poilvache, P.2    Nzeusseu, A.3    van Egeren, A.4    Devogelaer, J.P.5    Lenz, M.E.6    Thonar, E.J.7
  • 51
    • 0030004293 scopus 로고    scopus 로고
    • F lander s G Rutledge J. Measurement of serum hyaluronic acid in patients with rheumatoid arthritis: correlation with disease activity
    • Emlen W, Niebur J, F lander s G, Rutledge J. Measurement of serum hyaluronic acid in patients with rheumatoid arthritis: correlation with disease activity. J Rheumatol. 1996; 23:974-978.
    • (1996) J Rheumatol , vol.23 , pp. 974-978
    • Emlen, W.1    Niebur, J.2
  • 52
    • 0028256364 scopus 로고
    • Relationship between procollagen III aminoterminal propeptide and hyaluronan serum levels and histological fibrosis in primary biliary cirrhosis and chronic viral hepatitis C
    • Guechot J, Poupon RE, Giral P, Balkau B, Giboudeau J, Poupon R. Relationship between procollagen III aminoterminal propeptide and hyaluronan serum levels and histological fibrosis in primary biliary cirrhosis and chronic viral hepatitis C. J Hepatol. 1994; 20:388-393.
    • (1994) J Hepatol , vol.20 , pp. 388-393
    • Guechot, J.1    Poupon, R.E.2    Giral, P.3    Balkau, B.4    Giboudeau, J.5    Poupon, R.6
  • 54
    • 77952302657 scopus 로고    scopus 로고
    • Inflammaging (inflammation+aging): A driving force for human aging based on an evolutionarily antagonistic pleiotrpy theory
    • Goto M. Inflammaging (inflammation+aging): A driving force for human aging based on an evolutionarily antagonistic pleiotrpy theory? BioSci Trends. 2008; 2:218-230.
    • (2008) BioSci Trends , vol.2 , pp. 218-230
    • Goto, M.1
  • 55
    • 0002466735 scopus 로고
    • Age-and sex-related changes of the lymphocyte subsets in healthy individuals: an analysis by two-dimensional flow cytometry
    • Goto M, Nishioka K. Age-and sex-related changes of the lymphocyte subsets in healthy individuals: an analysis by two-dimensional flow cytometry. J Gerontol. 1989; 44:M51-56.
    • (1989) J Gerontol , vol.44
    • Goto, M.1    Nishioka, K.2
  • 56
    • 0018731552 scopus 로고
    • Immunological abnormalities of aging: an analysis of T lymphocyte subpopulations of Werner's syndrome
    • Goto M, Horiuchi Y, Okumura K, Tada T, Kawata M, Ohmori K. Immunological abnormalities of aging: an analysis of T lymphocyte subpopulations of Werner's syndrome. J Clin Invest. 1979; 64:695-699.
    • (1979) J Clin Invest , vol.64 , pp. 695-699
    • Goto, M.1    Horiuchi, Y.2    Okumura, K.3    Tada, T.4    Kawata, M.5    Ohmori, K.6
  • 57
    • 0020068261 scopus 로고
    • Reduced natural killer cell activity of lumphocytes from patients with Werner's syndrome and recovery of its activity by purified human leukocyte interferon
    • Goto M, Tanimoto K, Horiuchi Y, Kuwata T. Reduced natural killer cell activity of lumphocytes from patients with Werner's syndrome and recovery of its activity by purified human leukocyte interferon. Scand J Immunol. 1982; 15:389-397.
    • (1982) Scand J Immunol , vol.15 , pp. 389-397
    • Goto, M.1    Tanimoto, K.2    Horiuchi, Y.3    Kuwata, T.4
  • 58
    • 0019976235 scopus 로고
    • Age-related changes in auto-and natural antibody in the Werner's syndrome
    • Goto M, Tanimoto K, Aotsuka A, Okawa M, Yokohari R. Age-related changes in auto- and natural antibody in the Werner's syndrome. Am J Med. 1982; 72:607-614.
    • (1982) Am J Med , vol.72 , pp. 607-614
    • Goto, M.1    Tanimoto, K.2    Aotsuka, A.3    Okawa, M.4    Yokohari, R.5
  • 60
    • 0000606515 scopus 로고
    • Immunosenescent features of human segmental progeroid syndrome: Werner's syndrome
    • Goto M. Immunosenescent features of human segmental progeroid syndrome: Werner's syndrome. Aging Immunol Infect Dis. 1992; 3:203-215.
    • (1992) Aging Immunol Infect Dis , vol.3 , pp. 203-215
    • Goto, M.1
  • 62
    • 0022293135 scopus 로고
    • Neuropathology of Werner syndrome
    • (Salk D, Fujiwara Y, Martin GM. eds.). Plenum Press, New York, USA
    • Sumi SM. Neuropathology of Werner syndrome. In: Werner's syndrome and human aging. Advances in experimental medicine and biology. Vol. 190. (Salk D, Fujiwara Y, Martin GM. eds.). Plenum Press, New York, USA, 1985; pp. 215-218.
    • (1985) Werner's syndrome and human aging. Advances in experimental medicine and biology , vol.190 , pp. 215-218
    • Sumi, S.M.1
  • 63
    • 0034792391 scopus 로고    scopus 로고
    • Nervous system disorders in Werner syndrome
    • Gann Monograph on Cancer Research No.49. (Goto M, Miller RW, eds.). Karger, Tokyo, Japan
    • Kuroda Y. Nervous system disorders in Werner syndrome. In: From premature gray hair to helicase- Werner syndrome:Implications for aging and cancer. Gann Monograph on Cancer Research No.49. (Goto M, Miller RW, eds.). Karger, Tokyo, Japan, 2001; pp. 69-75.
    • (2001) From premature gray hair to helicase-Werner syndrome:Implications for aging and cancer , pp. 69-75
    • Kuroda, Y.1
  • 64
  • 66
    • 84875924167 scopus 로고    scopus 로고
    • A case of Werner syndrome associated with multiple meningioma
    • in Japanese
    • Amagasa M, Yuda F. A case of Werner syndrome associated with multiple meningioma. Yamagata Saiseikann Ishi. 2005; 30:83-88. (in Japanese).
    • (2005) Yamagata Saiseikann Ishi , vol.30 , pp. 83-88
    • Amagasa, M.1    Yuda, F.2
  • 67
    • 0037353436 scopus 로고    scopus 로고
    • Lack of amyloid plaque formation in the central nervous system of a patient with Werner syndrome
    • Mori H, Tomiyama T, Maeda N, Ozawa K, Wakasa K. Lack of amyloid plaque formation in the central nervous system of a patient with Werner syndrome. Neuropathology. 2003; 23:51-56.
    • (2003) Neuropathology , vol.23 , pp. 51-56
    • Mori, H.1    Tomiyama, T.2    Maeda, N.3    Ozawa, K.4    Wakasa, K.5
  • 68
    • 84875942237 scopus 로고    scopus 로고
    • A consideration on the background and pathogenesis of mood disorder in Werner syndrome
    • in Japanese
    • Maekawa A, Fukudome K, Masuda Y, Sugawara H, Kubo T. A consideration on the background and pathogenesis of mood disorder in Werner syndrome. Shinshini. 2005; 45:236. (in Japanese).
    • (2005) Shinshini , vol.45 , pp. 236
    • Maekawa, A.1    Fukudome, K.2    Masuda, Y.3    Sugawara, H.4    Kubo, T.5
  • 69
    • 0033559218 scopus 로고    scopus 로고
    • Unusual features of thyroid carcinomas in Japanese patients with Werner syndrome and possible genotype-phenotype relations to cell type and race
    • Ishikawa Y, Sugano H, Matsumoto T, Furuichi Y, Miller RW, Goto M. Unusual features of thyroid carcinomas in Japanese patients with Werner syndrome and possible genotype-phenotype relations to cell type and race. Cancer. 1999; 85:1345-1352.
    • (1999) Cancer , vol.85 , pp. 1345-1352
    • Ishikawa, Y.1    Sugano, H.2    Matsumoto, T.3    Furuichi, Y.4    Miller, R.W.5    Goto, M.6
  • 72
    • 0344867894 scopus 로고    scopus 로고
    • Prevalence of Werner's syndrome heterozygotes in Japan
    • Satoh M, Imai M, Sugimoto M, Goto M, Furuichi Y. Prevalence of Werner's syndrome heterozygotes in Japan. Lancet. 1999; 353:1766.
    • (1999) Lancet , vol.353 , pp. 1766
    • Satoh, M.1    Imai, M.2    Sugimoto, M.3    Goto, M.4    Furuichi, Y.5
  • 74
    • 0014816132 scopus 로고
    • Replicative life-span of cultivated human cells
    • Martin GM, Sprague CR, Epstein CJ. Replicative life-span of cultivated human cells. Lab Invest. 1970; 23:86-92.
    • (1970) Lab Invest , vol.23 , pp. 86-92
    • Martin, G.M.1    Sprague, C.R.2    Epstein, C.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.