Phosphoinositide turnover in Toll-like receptor signaling and trafficking

BMB Reports

Volumn 47, Issue 7, 2014, Pages 361-368

  Le, Oanh Thi Tu ^a   Nguyen, Tu Thi Ngoc ^a   Lee, Sang Yoon ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

Membrane; Phosphoinositide; PI(4,5)P2; Signaling; Toll like receptor; Trafficking

Indexed keywords

INTERLEUKIN 1 RECEPTOR; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE; POLYPHOSPHOINOSITIDE; TIRAP PROTEIN, HUMAN; TOLL LIKE RECEPTOR;

HUMAN; METABOLISM; SIGNAL TRANSDUCTION;

HUMANS; MEMBRANE GLYCOPROTEINS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASES; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 84905923785     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2014.47.7.088     Document Type: Short Survey

References (70)

1. Martin, T. F. (1998) Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking. Annu. Rev. Cell Dev. Biol. 14, 231-264.
2. Di Paolo, G. and De Camilli, P. (2006) Phosphoinositides in cell regulation and membrane dynamics. Nature 443, 651-657.
3. Varnai, P. and Balla, T. (2006) Live cell imaging of phosphoinositide dynamics with fluorescent protein domains. Biochim. Biophys. Acta 1761, 957-967.
4. Liu, Y. and Bankaitis, V. A. (2010) Phosphoinositide phosphatases in cell biology and disease. Prog. Lipid Res. 49, 201-217.
5. Sasaki, T., Takasuga, S., Sasaki, J., Kofuji, S., Eguchi, S., Yamazaki, M. and Suzuki, A. (2009) Mammalian phosphoinositide kinases and phosphatases. Prog. Lipid Res. 48, 307-343.
6. Strahl, T. and Thorner, J. (2007) Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae. Biochim. Biophys. Acta 1771, 353-404.
7. Blero, D., Payrastre, B., Schurmans, S. and Erneux, C. (2007) Phosphoinositide phosphatases in a network of signalling reactions. Pflugers Arch. - Eur. J. Physiol. 455, 31-44.
8. Vicinanza, M., D'Angelo, G., Di Campli, A. and De Matteis, M. A. (2008) Phosphoinositides as regulators of membrane trafficking in health and disease. Cell. Mol. Life Sci. 65, 2833-2841.
9. Halstead, J. R., Jalink, K. and Divecha, N. (2005) An emerging role for PtdIns(4,5)P2-mediated signalling in human disease. Trends Pharmacol. Sci. 26, 654-660.
10. McCrea, H. J. and De Camilli, P. (2009) Mutations in phosphoinositide metabolizing enzymes and human disease. Physiology 24, 8-16.
11. Kwiatkowska, K. (2010) One lipid, multiple functions: how various pools of PI(4,5)P2 are created in the plasma membrane. Cell. Mol. Life Sci. 67, 3927-3946.
12. Takenawa, T. and Itoh, T. (2001) Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane. Biochim. Biophys. Acta 1533, 190-206.
13. van den Bout, I. and Divecha, N. (2009) PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions. J. Cell Sci. 122, 3837-3850.
14. Doughman, R. L., Firestone, A. J. and Anderson, R. A. (2003) Phosphatidylinositol phosphate kinases put PI4,5P(2) in its place. J. Membr. Biol. 194, 77-89.
15. Ishihara, H., Shibasaki, Y., Kizuki, N., Katagiri, H., Yazaki, Y., Asano, T. and Oka, Y. (1996) Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J. Biol. Chem. 271, 23611-23614.
16. Ishihara, H., Shibasaki, Y., Kizuki, N., Wada, T., Yazaki, Y., Asano, T. and Oka, Y. (1998) Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J. Biol. Chem. 273, 8741-8748.
17. Kanaho, Y., Kobayashi-Nakano, A. and Yokozeki, T. (2007) The phosphoinositide kinase PIP5K that produces the versatile signaling phospholipid PI4,5P(2). Biol. Pharm. Bull. 30, 1605-1609.
18. Rebecchi, M. J. and Pentyala, S. N. (2000) Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol. Rev. 80, 1291-1335.
19. Mao, Y. S. and Yin, H. L. (2007) Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases. Pflugers Arch. - Eur. J. Physiol. 455, 5-18.
20. Cremona, O., Di Paolo, G., Wenk, M. R., Luthi, A., Kim, W. T., Takei, K., Daniell, L., Nemoto, Y., Shears, S. B., Flavell, R. A., McCormick, D. A. and De Camilli, P. (1999) Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cell 99, 179-188.
21. Wenk, M. R., Pellegrini, L., Klenchin, V. A., Di Paolo, G., Chang, S., Daniell, L., Arioka, M., Martin, T. F. and De Camilli, P. (2001) PIP kinase Igamma is the major PI(4,5) P(2) synthesizing enzyme at the synapse. Neuron 32, 79-88.
22. Hammond, G. R. and Schiavo, G. (2007) Polyphosphoinositol lipids: under-PPInning synaptic function in health and disease. Dev. Neurobiol. 67, 1232-1247.
23. Mao, Y. S., Yamaga, M., Zhu, X., Wei, Y., Sun, H. Q., Wang, J., Yun, M., Wang, Y., Di Paolo, G., Bennett, M., Mellman, I., Abrams, C. S., De Camilli, P., Lu, C. Y. and Yin, H. L. (2009) Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis. J. Cell Biol. 184, 281-296.
24. Botelho, R. J., Teruel, M., Dierckman, R., Anderson, R., Wells, A., York, J. D., Meyer, T. and Grinstein, S. (2000) Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. J. Cell Biol. 151, 1353-1368.
25. Krauß, M. and Haucke, V. (2007) Phosphoinositides: Regulators of membrane traffic and protein function. FEBS Lett. 581, 2105-2111.
26. Roth, M. G. (2004) Phosphoinositides in constitutive membrane traffic. Physiol. Rev. 84, 699-730.
27. Balla, T. (2005) Inositol-lipid binding motifs: signal integrators through protein-lipid and protein-protein interactions. J. Cell Sci. 118, 2093-2104.
28. Takenawa, T. and Itoh, T. (2006) Membrane targeting and remodeling through phosphoinositide-binding domains. IUBMB Life 58, 296-303.
29. Takeuchi, O. and Akira, S. (2010) Pattern recognition receptors and inflammation. Cell 140, 805-820.
30. Kawai, T. and Akira, S. (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373-384.
31. Akira, S., Uematsu, S. and Takeuchi, O. (2006) Pathogen recognition and innate immunity. Cell 124, 783-801.
32. Akira, S. and Takeda, K. (2004) Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499-511.
33. Olson, J. K. and Miller, S. D. (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173, 3916-3924.
34. Jack, C. S., Arbour, N., Manusow, J., Montgrain, V., Blain, M., McCrea, E., Shapiro, A. and Antel, J. P. (2005) TLR signaling tailors innate immune responses in human microglia and astrocytes. J. Immunol. 175, 4320-4330.
35. Lehnardt, S. (2010) Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury. Glia 58, 253-263.
36. Aloisi, F. (2001) Immune function of microglia. Glia 36, 165-179.
37. Teismann, P. and Schulz, J. B. (2004) Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation. Cell Tissue Res. 318, 149-161.
38. Carpentier, P. A., Duncan, D. S. and Miller, S. D. (2008) Glial toll-like receptor signaling in central nervous system infection and autoimmunity. Brain Behav. Immun. 22, 140-147.
39. Farina, C., Aloisi, F. and Meinl, E. (2007) Astrocytes are active players in cerebral innate immunity. Trends Immunol. 28, 138-145.
40. Block, M. L., Zecca, L. and Hong, J. S. (2007) Microgliamediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8, 57-69.
41. Jin, J. J., Kim, H. D., Maxwell, J. A., Li, L. and Fukuchi, K. (2008) Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease. J. Neuroinflammation 5, 23.
42. Walter, S., Letiembre, M., Liu, Y., Heine, H., Penke, B., Hao, W., Bode, B., Manietta, N., Walter, J., Schulz-Schuffer, W. and Fassbender, K. (2007) Role of the tolllike receptor 4 in neuroinflammation in Alzheimer's disease. Cell. Physiol. Biochem. 20, 947-956.
43. Block, M. L., Zecca, L. and Hong, J.-S. (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8, 57-69.
44. Okun, E., Griffioen, K. J., Lathia, J. D., Tang, S. C., Mattson, M. P. and Arumugam, T. V. (2009) Toll-like receptors in neurodegeneration. Brain Res. Rev. 59, 278-292.
45. O'Neill, L. A. and Bowie, A. G. (2007) The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 7, 353-364.
46. Kawai, T. and Akira, S. (2007) Signaling to NF-kappaB by Toll-like receptors. Trends Mol. Med. 13, 460-469.
47. Yamamoto, M., Sato, S., Hemmi, H., Sanjo, H., Uematsu, S., Kaisho, T., Hoshino, K., Takeuchi, O., Kobayashi, M., Fujita, T., Takeda, K. and Akira, S. (2002) Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 420, 324-329.
48. Fitzgerald, K. A., Palsson-McDermott, E. M., Bowie, A. G., Jefferies, C. A., Mansell, A. S., Brady, G., Brint, E., Dunne, A., Gray, P., Harte, M. T., McMurray, D., Smith, D. E., Sims, J. E., Bird, T. A. and O'Neill, L. A. (2001) Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413, 78-83.
49. Horng, T., Barton, G. M., Flavell, R. A. and Medzhitov, R. (2002) The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 420, 329-333.
50. Li, Q. and Verma, I. M. (2002) NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2, 725-734.
51. Horng, T., Barton, G. M. and Medzhitov, R. (2001) TIRAP: an adapter molecule in the Toll signaling pathway. Nat. Immunol. 2, 835-841.
52. Kagan, J. C. and Medzhitov, R. (2006) Phosphoinositidemediated adaptor recruitment controls Toll-like receptor signaling. Cell 125, 943-955.
53. Nagpal, K., Plantinga, T. S., Wong, J., Monks, B. G., Gay, N. J., Netea, M. G., Fitzgerald, K. A. and Golenbock, D. T. (2009) A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. J. Biol. Chem. 284, 25742-25748.
54. Marek, L. R. and Kagan, J. C. (2012) Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila. Immunity 36, 612-622.
55. Funakoshi, Y., Hasegawa, H. and Kanaho, Y. (2011) Regulation of PIP5K activity by Arf6 and its physiological significance. J. Cell. Physiol. 226, 888-895.
56. Wan, T., Liu, T., Zhang, H., Tang, S. and Min, W. (2010) AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling. J. Biol. Chem. 285, 3750-3757.
57. Lee, S. Y., Kim, B., Jeong, H. K., Min, K. J., Liu, T., Park, J. Y., Joe, E. H. and Jou, I. (2010) Enhanced phosphatidylinositol 4-phosphate 5-kinase alpha expression and PI(4,5)P2 production in LPS-stimulated microglia. Neurochem. Int. 57, 600-607.
58. Lee, S. Y., Kim, B., Yoon, S., Kim, Y. J., Liu, T., Woo, J. H., Chwae, Y. J., Joe, E. H. and Jou, I. (2010) Phosphatidylinositol 4-phosphate 5-kinase alpha is induced in ganglioside-stimulated brain astrocytes and contributes to inflammatory responses. Exp. Mol. Med. 42, 662-673.
59. Jou, I., Lee, J. H., Park, S. Y., Yoon, H. J., Joe, E. H. and Park, E. J. (2006) Gangliosides trigger inflammatory responses via TLR4 in brain glia. Am. J. Pathol. 168, 1619-1630.
60. Nguyen, T. T., Kim, Y. M., Kim, T. D., Le, O. T., Kim, J. J., Kang, H. C., Hasegawa, H., Kanaho, Y., Jou, I. and Lee, S. Y. (2013) Phosphatidylinositol 4-phosphate 5-kinase alpha facilitates Toll-like receptor 4-mediated microglial inflammation through regulation of the Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP) location. J. Biol. Chem. 288, 5645-5659.
61. Choi, Y. J., Jung, J., Chung, H. K., Im, E. and Rhee, S. H. (2013) PTEN regulates TLR5-induced intestinal inflammation by controlling Mal/TIRAP recruitment. FASEB J. 27, 243-254.
62. Barton, G. M. and Kagan, J. C. (2009) A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat. Rev. Immunol. 9, 535-542.
63. Kagan, J. C., Su, T., Horng, T., Chow, A., Akira, S. and Medzhitov, R. (2008) TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat. Immunol. 9, 361-368.
64. Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K. and Akira, S. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301, 640-643.
65. Yamamoto, M., Sato, S., Hemmi, H., Uematsu, S., Hoshino, K., Kaisho, T., Takeuchi, O., Takeda, K. and Akira, S. (2003) TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat. Immunol. 4, 1144-1150.
66. Fitzgerald, K. A., Rowe, D. C., Barnes, B. J., Caffrey, D. R., Visintin, A., Latz, E., Monks, B., Pitha, P. M. and Golenbock, D. T. (2003) LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J. Exp. Med. 198, 1043-1055.
67. Watts, C. (2008) Location, location, location: identifying the neighborhoods of LPS signaling. Nat. Immunol. 9, 343-345.
68. Brandt, K. J., Fickentscher, C., Kruithof, E. K. and de Moerloose, P. (2013) TLR2 ligands induce NF-kappaB activation from endosomal compartments of human monocytes. PLoS One 8, e80743.
69. Zanoni, I., Ostuni, R., Marek, L. R., Barresi, S., Barbalat, R., Barton, G. M., Granucci, F. and Kagan, J. C. (2011) CD14 controls the LPS-induced endocytosis of Toll-like receptor Cell 147, 868-880.
70. Chiang, C. Y., Veckman, V., Limmer, K. and David, M. (2012) Phospholipase Cgamma-2 and intracellular calcium are required for lipopolysaccharide-induced Toll-like receptor 4 (TLR4) endocytosis and interferon regulatory factor 3 (IRF3) activation. J. Biol. Chem. 287, 3704-3709.