A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling

Journal of Biological Chemistry

Volumn 284, Issue 38, 2009, Pages 25742-25748

  Nagpal, Kamalpreet ^a   Plantinga, Theo S ^b   Wong, Joyce ^c   Monks, Brian G ^a   Gay, Nicholas J ^c   Netea, Mihai G ^b   Fitzgerald, Katherine A ^a   Golenbock, Douglas T ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTER PROTEINS; CELL LINES; CO-IMMUNOPRECIPITATIONS; CODING REGION; COMPUTER MODELING; CYTOKINE PRODUCTION; GENOTYPING; LIPOPOLYSACCHARIDES; REPORTER ASSAY; SINGLE NUCLEOTIDE POLYMORPHISMS; TOLL-LIKE RECEPTORS;

BINDING ENERGY; BINDING SITES; CELL CULTURE; CELL MEMBRANES; POLYSACCHARIDES;

SIGNALING;

BETA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; INTERLEUKIN 1 RECEPTOR; LIPOPEPTIDE; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; MYD88 PROTEIN, HUMAN; PAM(3)CSK(4) PEPTIDE; TIRAP PROTEIN, HUMAN; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; GENE LOSS; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; AMINO ACID SUBSTITUTION; CELL LINE; CHEMICAL STRUCTURE; COHORT ANALYSIS; COMPUTER SIMULATION; DRUG EFFECT; FEMALE; GENETICS; MALE; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM;

AMINO ACID SUBSTITUTION; BINDING SITES; CELL LINE; COHORT STUDIES; COMPUTER SIMULATION; FEMALE; HUMANS; LIPOPEPTIDES; LIPOPOLYSACCHARIDES; MALE; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MUTATION, MISSENSE; MYELOID DIFFERENTIATION FACTOR 88; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 70350026642     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.014886     Document Type: Article

References (38)

1. O'Neill, L. A. (2008) Immunity 29, 12-20
2. Hong-Geller, E., Chaudhary, A., and Lauer, S. (2008) Curr. Drug Discov. Technol. 5, 29-38
3. Fitzgerald, K. A., Palsson-McDermott, E. M., Bowie, A. G., Jefferies, C. A., Mansell, A. S., Brady, G., Brint, E., Dunne, A., Gray, P., Harte, M. T., McMurray, D., Smith, D. E., Sims, J. E., Bird, T. A., and O'Neill, L. A. (2001) Nature 413, 78-83
4. Horng, T., Barton, G. M., and Medzhitov, R. (2001) Nat. Immunol. 2, 835-841
5. Kagan, J. C., and Medzhitov, R. (2006) Cell 125, 943-955
6. Vogel, S. N., Fitzgerald, K. A., and Fenton, M. J. (2003) Mol. Interv. 3, 466-477
7. Hawn, T. R., Dunstan, S. J., Thwaites, G. E., Simmons, C. P., Thuong, N. T., Lan, N. T., Quy, H. T., Chau, T. T., Hieu, N. T., Rodrigues, S., Janer, M., Zhao, L. P., Hien, T. T., Farrar, J. J., and Aderem, A. (2006) J. Infect. Dis. 194, 1127-1134
8. Wurfel, M. M., Gordon, A. C., Holden, T. D., Radella, F., Strout, J., Kajikawa, O., Ruzinski, J. T., Rona, G., Black, R. A., Stratton, S., Jarvik, G. P., Hajjar, A. M., Nickerson, D. A., Rieder, M., Sevransky, J., Maloney, J. P., Moss, M., Martin, G., Shanholtz, C., Garcia, J. G., Gao, L., Brower, R., Barnes, K. C., Walley, K. R., Russell, J. A., and Martin, T. R. (2008) Am. J. Respir. Crit. Care Med. 178, 710-720
9. Khor, C. C., Chapman, S. J., Vannberg, F. O., Dunne, A., Murphy, C., Ling, E. Y., Frodsham, A. J., Walley, A. J., Kyrieleis, O., Khan, A., Aucan, C., Segal, S., Moore, C. E., Knox, K., Campbell, S. J., Lienhardt, C., Scott, A., Aaby, P., Sow, O. Y., Grignani, R. T., Sillah, J., Sirugo, G., Peshu, N., Williams, T. N., Maitland, K., Davies, R. J., Kwiatkowski, D. P., Day, N. P., Yala, D., Crook, D. W., Marsh, K., Berkley, J. A., O'Neill, L. A., and Hill, A. V. (2007) Nat. Genet. 39, 523-528
10. Vasl, J., Prohinar, P., Gioannini, T. L., Weiss, J. P., and Jerala, R. (2008) J. Immunol. 180, 6107-6115
11. Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S. M., and Maniatis, T. (2003) Nat. Immunol. 4, 491-496
12. Latz, E., Schoenemeyer, A., Visintin, A., Fitzgerald, K. A., Monks, B. G., Knetter, C. F., Lien, E., Nilsen, N. J., Espevik, T., and Golenbock, D. T. (2004) Nat. Immunol. 5, 190-198
13. Schoenemeyer, A., Barnes, B. J., Mancl, M. E., Latz, E., Goutagny, N., Pitha, P. M., Fitzgerald, K. A., and Golenbock, D. T. (2005) J. Biol. Chem. 280, 17005-17012
14. Fitzgerald, K. A., Rowe, D. C., Barnes, B. J., Caffrey, D. R., Visintin, A., Latz, E., Monks, B., Pitha, P. M., and Golenbock, D. T. (2003) J. Exp. Med. 198, 1043-1055
15. Hawley, R. G., Lieu, F. H., Fong, A. Z., and Hawley, T. S. (1994) Gene Ther. 1, 136-138
16. Yamamoto, M., Sato, S., Hemmi, H., Sanjo, H., Uematsu, S., Kaisho, T., Hoshino, K., Takeuchi, O., Kobayashi, M., Fujita, T., Takeda, K., and Akira, S. (2002) Nature 420, 324-329
17. Charrel-Dennis, M., Latz, E., Halmen, K. A., Trieu-Cuot, P., Fitzgerald, K. A., Kasper, D. L., and Golenbock, D. T. (2008) Cell Host Microbe 4, 543-554
18. Shi, J., Blundell, T. L., and Mizuguchi, K. (2001) J. Mol. Biol. 310, 243-257
19. Sali, A., and Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815
20. Núñez Miguel, R., Wong, J., Westoll, J. F., Brooks, H. J., O'Neill, L. A., Gay, N. J., Bryant, C. E., and Monie, T. P. (2007) PLoS ONE 2, e788
21. Topham, C. M., Srinivasan, N., and Blundell, T. L. (1997) Protein Eng. 10, 7-21
22. Ferwerda, B., McCall, M. B., Alonso, S., Giamarellos-Bourboulis, E. J., Mouktaroudi, M., Izagirre, N., Syafruddin, D., Kibiki, G., Cristea, T., Hijmans, A., Hamann, L., Israel, S., ElGhazali, G., Troye-Blomberg, M., Kumpf, O., Maiga, B., Dolo, A., Doumbo, O., Hermsen, C. C., Stalenhoef, A. F., van Crevel, R., Brunner, H. G., Oh, D. Y., Schumann, R. R., de la Rúa, C., Sauerwein, R., Kullberg, B. J., van der Ven, A. J., van der Meer, J. W., and Netea, M. G. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 16645-16650
23. Miggin, S. M., Pålsson-McDermott, E., Dunne, A., Jefferies, C., Pinteaux, E., Banahan, K., Murphy, C., Moynagh, P., Yamamoto, M., Akira, S., Rothwell, N., Golenbock, D., Fitzgerald, K. A., and O'Neill, L. A. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 3372-3377
24. Paun, A., Reinert, J. T., Jiang, Z., Medin, C., Balkhi, M. Y., Fitzgerald, K. A., and Pitha, P. M. (2008) J. Biol. Chem. 283, 14295-14308
25. Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., and Golenbock, D. T. (2008) Nat. Immunol. 9, 857-865
26. Meylan, E., Burns, K., Hofmann, K., Blancheteau, V., Martinon, F., Kelliher, M., and Tschopp, J. (2004) Nat. Immunol. 5, 503-507
27. McGettrick, A. F., and O'Neill, L. A. (2004) Mol. Immunol. 41, 577-582
28. Fitzgerald, K. A., and Chen, Z. J. (2006) Cell 125, 834-836
29. Xu, Y., Tao, X., Shen, B., Horng, T., Medzhitov, R., Manley, J. L., and Tong, L. (2000) Nature 408, 111-115
30. Worth, C. L., Bickerton, G. R., Schreyer, A., Forman, J. R., Cheng, T. M., Lee, S., Gong, S., Burke, D. F., and Blundell, T. L. (2007) J. Bioinform. Comput. Biol. 5, 1297-1318
31. von Bernuth, H., Picard, C., Jin, Z., Pankla, R., Xiao, H., Ku, C. L., Chrabieh, M., Mustapha, I. B., Ghandil, P., Camcioglu, Y., Vasconcelos, J., Sirvent, N., Guedes, M., Vitor, A. B., Herrero-Mata, M. J., Aróstegui, J. I., Rodrigo, C., Alsina, L., Ruiz-Ortiz, E., Juan, M., Fortuny, C., Yagüe, J., Antón, J., Pascal, M., Chang, H. H., Janniere, L., Rose, Y., Garty, B. Z., Chapel, H., Issekutz, A., Maródi, L., Rodriguez-Gallego, C., Banchereau, J., Abel, L., Li, X., Chaussabel, D., Puel, A., and Casanova, J. L. (2008) Science 321, 691-696
32. Davila, S., Hibberd, M. L., Hari Dass, R., Wong, H. E., Sahiratmadja, E., Bonnard, C., Alisjahbana, B., Szeszko, J. S., Balabanova, Y., Drobniewski, F., van Crevel, R., van de Vosse, E., Nejentsev, S., Ottenhoff, T. H., and Seielstad, M. (2008) PLoS Genet. 4, e1000218
33. Johnson, C. M., Lyle, E. A., Omueti, K. O., Stepensky, V. A., Yegin, O., Alpsoy, E., Hamann, L., Schumann, R. R., and Tapping, R. I. (2007) J. Immunol. 178, 7520-7524
34. Schumann, R. R., and Tapping, R. I. (2007) Eur. J. Immunol. 37, 2059-2062
35. Seabury, C. M., Cargill, E. J., and Womack, J. E. (2007) Genomics 90, 502-515
36. Medvedev, A. E., Lentschat, A., Kuhns, D. B., Blanco, J. C., Salkowski, C., Zhang, S., Arditi, M., Gallin, J. I., and Vogel, S. N. (2003) J. Exp. Med. 198, 521-531
37. Picard, C., Puel, A., Bonnet, M., Ku, C. L., Bustamante, J., Yang, K., Soudais, C., Dupuis, S., Feinberg, J., Fieschi, C., Elbim, C., Hitchcock, R., Lammas, D., Davies, G., Al-Ghonaium, A., Al-Rayes, H., Al-Jumaah, S., Al-Hajjar, S., Al-Mohsen, I. Z., Frayha, H. H., Rucker, R., Hawn, T. R., Aderem, A., Tufenkeji, H., Haraguchi, S., Day, N. K., Good, R. A., Gougerot-Pocidalo, M. A., Ozinsky, A., and Casanova, J. L. (2003) Science 299, 2076-2079
38. DeLano, W. (2002) Pymol, DeLano Scientific, Palo Alto, CA