Phosphatidylinositol 4-phosphate 5-kinase α is induced in ganglioside-stimulated brain astrocytes and contributes to inflammatory responses

Experimental and Molecular Medicine

Volumn 42, Issue 9, 2010, Pages 662-673

  Lee, Sang Yoon ^a   Kim, Bokyung ^a   Yoon, Sarah ^a   Kim, Yeon Joo ^a   Liu, Tian ^a   Woo, Joo Hong ^a   Chwae, Yong Joon ^a   Joe, Eun hye ^a   Jou, Ilo ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

1 phosphatidylinositol 4 phosphate 5 kinase; Astrocytes; Brain; Gangliosides; Inflammation; NF B

Indexed keywords

FLUORESCENT DYE; GANGLIOSIDE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; MICRORNA; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE ALPHA; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN TISSUE; CELL NUCLEUS; CONTROLLED STUDY; ENCEPHALITIS; ENZYME INDUCTION; ENZYME SYNTHESIS; GENE ACTIVATION; IMMUNE RESPONSE; MEMBRANE DAMAGE; NERVE CELL MEMBRANE; NEWBORN; NONHUMAN; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION;

PHOS;

EID: 77957723901     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2010.42.9.066     Document Type: Article

References (36)

1. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004; 4:499-511
2. Ariga T, McDonald MP, Yu RK. Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a review. J Lipid Res 2008; 49:1157-75
3. Blennow K, Davidsson P, Wallin A, Fredman P, Gottfries CG, Mansson JE, Svennerholm L. Differences in cerebrospinal fluid gangliosides between probable Alzheimer's disease and normal aging. Aging (Milano) 1992; 4:301-6
4. Di Paolo G, De Camilli P. Phosphoinositides in cell regulation and membrane dynamics. Nature 2006; 443:651-7
5. Doughman RL, Firestone AJ, Anderson RA. Phospha-tidylinositol phosphate kinases put PI4,5P(2) in its place. J Membr Biol 2003; 194:77-89
6. Farina C, Aloisi F, Meinl E. Astrocytes are active players in cerebral innate immunity. Trends Immunol 2007; 28:138-45
7. Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 2001; 413:78-83
8. Horng T, Barton GM, Flavell RA, Medzhitov R. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 2002; 420:329-33
9. Ishihara H, Shibasaki Y, Kizuki N, Katagiri H, Yazaki Y, Asano T, Oka Y. Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem 1996; 271:23611-4
10. Ishihara H, Shibasaki Y, Kizuki N, Wada T, Yazaki Y, Asano T, Oka Y. Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J Biol Chem 1998; 273:8741-8
11. Jou I, Lee JH, Park SY, Yoon HJ, Joe EH, Park EJ. Gangliosides trigger inflammatory responses via TLR4 in brain glia. Am J Pathol 2006; 168:1619-30
12. Jung JU, Ko K, Lee DH, Ko K, Chang KT, Choo YK. The roles of glycosphingolipids in the proliferation and neural differentiation of mouse embryonic stem cells. Exp Mol Med 2009; 41:935-45
13. Kagan JC, Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 2006; 125:943-55
14. Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol 2002; 2:725-34
15. Lund S, Christensen KV, Hedtjarn M, Mortensen AL, Hagberg H, Falsig J, Hasseldam H, Schrattenholz A, Porzgen P, Leist M. The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditions. J Neuroimmunol 2006; 180: 71-87
16. Mao YS, Yin HL. Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases. Pflugers Arch 2007; 455:5-18
17. Min KJ, Pyo HK, Yang MS, Ji KA, Jou I, Joe EH. Gangliosides activate microglia via protein kinase C and NADPH oxidase. Glia 2004; 48:197-206
18. Padron D, Wang YJ, Yamamoto M, Yin H, Roth MG. Phosphatidylinositol phosphate 5-kinase Ibeta recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis. J Cell Biol 2003; 162:693-701
19. Pawate S, Shen Q, Fan F, Bhat NR. Redox regulation of glial inflammatory response to lipopolysaccharide and interfe-rongamma. J Neurosci Res 2004; 77:540-51
20. Posse de Chaves E, Sipione S. Sphingolipids and gang-liosides of the nervous system in membrane function and dysfunction. FEBS Lett 2010; 584:1748-59
21. Pyo H, Joe E, Jung S, Lee SH, Jou I. Gangliosides activate cultured rat brain microglia. J Biol Chem 1999; 274:34584-9
22. Quinn KV, Behe P, Tinker A. Monitoring changes in membrane phosphatidylinositol 4,5-bisphosphate in living cells using a domain from the transcription factor tubby. J Physiol 2008; 586:2855-71
23. Rameh LE, Tolias KF, Duckworth BC, Cantley LC. A new pathway for synthesis of phosphatidylinositol-4,5-bi-sphosphate. Nature 1997; 390:192-6
24. Sakurai H, Chiba H, Miyoshi H, Sugita T, Toriumi W. IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. J Biol Chem 1999; 274: 30353-6
25. Santagata S, Boggon TJ, Baird CL, Gomez CA, Zhao J, Shan WS, Myszka DG, Shapiro L. G-protein signaling through tubby proteins. Science 2001; 292:2041-50
26. Sasaki J, Sasaki T, Yamazaki M, Matsuoka K, Taya C, Shitara H, Takasuga S, Nishio M, Mizuno K, Wada T, Miyazaki H, Watanabe H, Iizuka R, Kubo S, Murata S, Chiba T, Maehama T, Hamada K, Kishimoto H, Frohman MA, Tanaka K, Penninger JM, Yonekawa H, Suzuki A, Kanaho Y. Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med 2005; 201:859-70
27. Schwab C, McGeer PL. Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders. J Alzhei-mers Dis 2008; 13:359-69
28. Sonnino S, Chigorno V. Ganglioside molecular species containing C18- and C20-sphingosine in mammalian nervous tissues and neuronal cell cultures. Biochim Biophys Acta 2000; 1469:63-77
29. Suh BC, Hille B. Regulation of ion channels by phos-phatidylinositol 4,5-bisphosphate. Curr Opin Neurobiol 2005; 15:370-8
30. Szentpetery Z, Balla A, Kim YJ, Lemmon MA, Balla T. Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study. BMC Cell Biol 2009; 10:67
31. Szymanska E, Korzeniowski M, Raynal P, Sobota A, Kwiatkowska K. Contribution of PIP-5 kinase Ialpha to raft-based FcgammaRIIA signaling. Exp Cell Res 2009; 315: 981-95
32. Takenawa T, Itoh T. Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane. Biochim Biophys Acta 2001; 1533:190-206
33. Teismann P, Schulz JB. Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation. Cell Tissue Res 2004; 318:149-61
34. van den Bout I, Divecha N. PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions. J Cell Sci 2009; 122:3837-50
35. Yamamoto M, Hilgemann DH, Feng S, Bito H, Ishihara H, Shibasaki Y, Yin HL. Phosphatidylinositol 4,5-bisphosphate induces actin stress-fiber formation and inhibits membrane ruffling in CV1 cells. J Cell Biol 2001; 152:867-76
36. Yang F, Tang E, Guan K, Wang CY. IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. J Immunol 2003; 170: 5630-5