One lipid, multiple functions: How various pools of PI(4,5)P2 are created in the plasma membrane

Cellular and Molecular Life Sciences

Volumn 67, Issue 23, 2010, Pages 3927-3946

  Kwiatkowska, Katarzyna ^a  

^a NONE

Author keywords

AP 2; Lipid rafts; Phosphatidylinositol 4,5 bisphosphate; Plasma membrane; Rac1; Talin; Type I phosphatidylinositol 4 phosphate 5 kinases

Indexed keywords

PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE;

AMINO ACID SEQUENCE; AUTOPHOSPHORYLATION; CELL ACTIVATION; CELL MEMBRANE; ENZYME ACTIVITY; HUMAN; NONHUMAN; PROTEIN DEPHOSPHORYLATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN TARGETING; REVIEW;

ADAPTOR PROTEIN COMPLEX 2; AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; COATED PITS, CELL-MEMBRANE; FOCAL ADHESIONS; HUMANS; ISOENZYMES; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SEQUENCE ALIGNMENT; TALIN;

EID: 78651314456     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0432-5     Document Type: Review

References (183)

1. 32 into phospholipides of pancreas slices. J Biol Chem 203:967-977
2. Yin HL, Janmey PA (2003) Phosphoinositide regulation of the actin cytoskeleton. Annu Rev Physiol 65:761-789
3. Di Paolo G, De Camilli P (2006) Phosphoinositides in cell regulation and membrane dynamics. Nature 443:651-657
4. Rameh LE, Cantley LC (1999) The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 274:8347-8350
5. Maehama T, Dixon JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate. J Biol Chem 273:13375-13378
6. McPherson PS, Garcia EP, Slepnev VI, David C, Zhang X, Grabs D, Sossin WS, Bauerfeind R, Nemoto Y, De Camilli P (1996) A presynaptic inositol-5-phosphatase. Nature 379:353-357
7. Nemoto Y, Arribas M, Haffner C, DeCamilli P (1997) Synaptojanin 2, a novel synaptojanin isoform with a distinct targeting domain and expression pattern. J Biol Chem 272:30817-30821
8. Lowe M (2005) Structure and function of the Lowe syndrome protein OCRL. Traffic 6:711-719
9. Ungewickell A, Hugge C, Kisseleva M, Chang SC, Zou J, Feng Y, Galyov EE, Wilson M, Majerus PW (2005) The identification and characterization of two phosphatidylinositol-4, 5-bisphosphate 4-phosphatases. Proc Natl Acad Sci USA 102:18854-18859
10. Lowe CU, Terrey M, MacLachlan EA (1952) Organic-aciduria, decreased renal ammonia production, hydrophthalmos, and mental retardation; a clinical entity. AMA Am J Dis Child 83:164-184
11. Leahey AM, Charnas LR, Nussbaum RL (1993) Nonsense mutations in the OCRL-1 gene in patients with the oculocerebrorenal syndrome of Lowe. Hum Mol Genet 2:461-463
12. Cremona O, Di Paolo G, Wenk MR, Lüthi A, Kim WT, Takei K, Daniell L, Nemoto Y, Shears SB, Flavell RA, McCormick DA, De Camilli P (1999) Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cell 99:179-188
13. Voronov SV, Frere SG, Giovedi S, Pollina EA, Borel C, Zhang H, Schmidt C, Akeson EC, Wenk MR, Cimasoni L, Arancio O, Davisson MT, Antonarakis SE, Gardiner K, De Camilli P, Di Paolo G (2008) Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome. Proc Natl Acad Sci USA 105:9415-9420
14. Zou J, Marjanovic J, Kisseleva MV, Wilson M, Majerus PW (2007) Type I phosphatidylinositol-4, 5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. Proc Natl Acad Sci USA 104:16834-16839
15. Dove SK, Dong K, Kobayashi T, Williams FK, Michell RH (2009) Phosphatidylinositol 3, 5-bisphosphate and Fab1p/PIK-fyve underPPIn endo-lysosome function. Biochem J 419:1-13
16. Sbrissa D, Ikonomov OC, Deeb R, Shisheva A (2002) Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells. J Biol Chem 277:47276-47284
17. Coronas S, Lagarrigue F, Ramel D, Chicanne G, Delsol G, Payrastre B, Tronchere H (2008) Elevated levels of PtdIns5P in NPM-ALK transformed cells: implication of PIKfyve. Biochem Biophys Res Commun 372:351-355
18. Shisheva A 2008) PIKfyve: partners, significance, debates, paradoxes. Cell Biol Int 32:591-604
19. Tolias KF, Rameh LE, Ishihara H, Shibasaki Y, Chen J, Prestwich GD, Cantley LC, Carpenter C (1998) Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3, 5-bisphosphate and phosphatidylinositol 5-phosphate. J Biol Chem 273:18040-18046
20. 2 production for endomembrane integrity. J Biol Chem 277:9206-9211
21. Ishihara H, Shibasaki Y, Kizuki N, Katagiri H, Yazaki Y, Asano T, Oka y (1996) Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem 271:23611-23614
22. Loijens JC, Anderson RA (1996) Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family. J Biol Chem 271:32937-32943
23. Ishihara H, Shibasaki Y, Kizuki N, Wada T, Yazaki Y, Asano T, Oka y (1998) Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J Biol Chem 273:8741-8748
24. Giudici ML, Emson PC, Irvine RF (2004) A novel neuronalspecific splice variant of type I phosphatidylinositol 4-phosphate 5-kinase isoform c. Biochem J 379:489-496
25. 2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking. Nature 431:415-422
26. Jenkins GH, Fisette PL, Anderson RA (1994) Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid. J Biol Chem 269:11547-11554
27. Itoh T, Ishihara H, Shibasaki Y, Oka Y, Takenawa T (2000) Autophosphorylation of type I phosphatidylinositol phosphate kinase regulates its lipid kinase activity. J Biol Chem 275:19389-19394
28. Park SJ, Itoh T, Takenawa T (2001) Phosphatidylinositol 4-phosphate 5-kinase type I is regulated through phosphorylation response by extracellular stimuli. J Biol Chem 276:4781-4787
29. Di Paolo G, Pellegrini L, Letinic K, Cestra G, Zoncu R, Voronov S, Chang S, Guo J, Wenk MR, De Camilli P (2002) Recruitment and regulation of phosphatidylinositol phosphate kinase type 1c by the FERM domain of talin. Nature 420:85-89
30. Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA (2002) Type Ic phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature 420:89-93
31. 2-regulated nuclear poly (A) polymerase controls expression of select mRNAs. Nature 451:1013-1017
32. Chang JD, Field SJ, Rameh LE, Carpenter CL, Cantley LC (2004) Identification and characterization of a phosphoinositide phosphate kinase homolog. J Biol Chem 279:11672-11679
33. Tolias KF, Hartwig JH, Ishihara H, Shibasaki Y, Cantley LC, Carpenter CL (2000) Type Ia phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Curr Biol 10:153-156
34. Yamamoto M, Chen MZ, Wang YJ, Sun HQ, Wei Y, Martinez M, Yin HL (2006) Hypertonic stress increases phosphatidylinositol 4, 5-bisphosphate levels by activating PIP5KIb. J Biol Chem 281:32630-32638
35. Wang Y, Litvinov RI, Chen X, Bach TL, Lian L, Petrich BG, Monkley SJ, Kanaho Y, Critchley DR, Sasaki T, Birnbaum MJ, Weisel JW, Hartwig J, Abrams CS (2008) Loss of PIP5KIc, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murinsmegakaryocytes. J Clin Invest 118:812-881
36. 2 synthesis is required for IP3 formation. Proc Natl Acad Sci USA 105:14064-14069
37. Mao YS, Yamaga M, Zhu X, Wei Y, Sun H, Wang J, Yun M, Wang Y, Di Paolo G, Bennett M, Mellman I, Abrams CS, De Camilli P, Lu CY, Yin HL (2009) Essential and unique roles of PIP5K-c and -a in Fcc receptor-mediated phagocytosis. J Cell Biol 184:281-296
38. Coppolino MG, Dierckman R, Loijens J, Collins RF, Pouladi M, Jongstra-Bilen J, Schreiber AD, Trimble WS, Anderson R, Grinstein S (2002) Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ia impairs localized actin remodeling and suppresses phagocytosis. J Biol Chem 277:43849-43857
39. Doughman RL, Firestone AJ, Wojtasiak ML, Bunce MW, Anderson RA (2003) Membrane ruffling requires coordination between type Ia phosphatidylinositol phosphate kinase and Rac signaling. J Biol Chem 278:23036-23045
40. Kisseleva M, Feng Y, Ward M, Song C, Anderson RA, Longmore GD (2005) The LIM protein Ajuba regulates phosphatidylinositol 4, 5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKIα. Mol Cell Biol 25:3956-3966
41. Chen MZ, Zhu X, Sun HQ, Mao YS, Wei Y, Yamamoto M, Yin HL (2009) Oxidative stress decreases phosphatidylinositol 4, 5-bisphosphate levels by deactivating phosphatidylinositol-4-phosphate 5-kinase β in a Syk-dependent manner. J Biol Chem 284:23743-23753
42. Tolias KF, Couvillon AD, Cantley LC, Carpenter CL (1998) Characterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex. Mol Cell Biol 18:762-770
43. Szymanska E, Korzeniowski M, Raynal P, Sobota A, Kwiatkowska K (2009) Contribution of PIP-5 kinase Iα to raft-based FccRIIA signaling. Exp Cell Res 315:981-995
44. Shibasaki Y, Ishihara H, Kizuki N, Asano T, Oka Y, Yazaki y (1997) Massive actin polymerization induced by phosphatidylinositol-4-phosphate 5-kinase in vivo. J Biol Chem 272:7578-7581
45. Rozelle AL, Machesky LM, Yamamoto M, Driessens MH, Insall RH, Roth MG, Luby-Phelps K, Marriott G, Hall A, Yin HL (2000) Phosphatidylinositol 4, 5-bisphosphate induces actinbased movement of raft-enriched vesicles through WASP-Arp2/3. Curr Biol 10:311-320
46. Yamamoto M, Hilgemann DH, Feng S, Bito H, Ishihara H, Shibasaki Y, Yin HL (2001) Phosphatidylinositol 4, 5-bisphosphate induces actin stress-fiber formation and inhibits membrane ruffling in CV1 cells. J Cell Biol 152:867-876
47. Boronenkov IV, Loijens JC, Umeda M, Anderson RA (1998) Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. Mol Biol Cell 9:3547-3560
48. Padron D, Wang YJ, Yamamoto M, Yin H, Roth MG (2003) Phosphatidylinositol phosphate 5-kinase Iβ recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis. J Cell Biol 162:693-701
49. Bairstow SF, Ling K, Su X, Firestone AJ, Carbonara C, Anderson RA (2006) Type Iγ661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis. J Biol Chem 281:20632-20642
50. Krauss M, Kukhtina V, Pechstein A, Haucke V (2006) Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4, 5)-bisphosphate synthesis by AP-2 μ-cargo complexes. Proc Natl Acad Sci USA 103:11934-11939
51. Nakano-Kobayashi A, Yamazaki M, Unoki T, Hongu T, Murata C, Taguchi R, Katada T, Frohman MA, Yokozeki T, Kanaho y (2007) Role of activation of PIP5Kγ661 by AP-2 complex in synaptic vesicle endocytosis. EMBO J 26:1105-1116
52. Ling K, Doughman RL, Iyer VV, Firestone AJ, Bairstow SF, Mosher DF, Schaller MD, Anderson RA (2003) Tyrosine phosphorylation of type Iγ phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch. J Cell Biol 163:1339-1349
53. Powner DJ, Payne RM, Pettitt TR, Giudici ML, Irvine RF, Wakelam MJ (2005) Phospholipase D2 stimulates integrinmediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Iγb. J Cell Sci 118:2975-2986
54. El Sayegh TY, Arora PD, Ling K, Laschinger C, Janmey PA, Anderson RA, McCulloch CA (2007) Phosphatidylinositol-4, 5 bisphosphate produced by PIP5KIγ regulates gelsolin, actin assembly, and adhesion strength of N-cadherin junctions. Mol Biol Cell 18:3026-3038
55. McEwen RK, Dove SK, Cooke FT, Painter GF, Holmes AB, Shisheva A, Ohya Y, Parker PJ, Michell RH (1999) Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases. J Biol Chem 274:33905-33912
56. Kunz J, Wilson MP, Kisseleva M, Hurley JH, Majerus PW, Anderson RA (2000) The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. Mol Cell 5:1-11
57. Homma K, Terui S, Minemura M, Qadota H, Anraku Y, Kanaho Y, Ohya y (1998) Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis. J Biol Chem 273:15779-15786
58. Boronenkov IV, Anderson RA (1995) The sequence of phosphatidylinositol-4- phosphate 5-kinase defines a novel family of lipid kinases. J Biol Chem 270:2881-2884
59. 55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem 272:5861-5870
60. Itoh T, Ijuin T, Takenawa T (1998) A novel phosphatidylinositol-5- phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIγ) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals. J Biol Chem 273:20292-20299
61. Rameh LE, Tolias KF, Duckworth BC, Cantley LC (1997) A new pathway for synthesis of phosphatidylinositol-4, 5-bisphosphate. Nature 390:192-196
62. Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH (1998) Structure of type IIβ phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. Cell 94:829-839
63. Clarke JH, Richardson JP, Hinchliffe KA, Irvine RF (2007) Type II PtdInsP kinases: location, regulation and function. Biochem Soc Symp 74:149-159
64. Ciruela A, Hinchliffe KA, Divecha N, Irvine RF (2000) Nuclear targeting of the β isoform of type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its α-helix 7. Biochem J 346:587-591
65. Bazenet CE, Ruano AR, Brockman JL, Anderson RA (1990) The human erythrocyte contains two forms of phosphatidylinositol-4-phosphate 5-kinase which are differentially active toward membranes. J Biol Chem 265:18012-18022
66. Whiteford CC, Brearley CA, Ulug ET (1997) Phosphatidylinositol 3, 5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts. Biochem J 323:597-601
67. Kunz J, Fuelling A, Kolbe L, Anderson RA (2002) Stereo-specific substrate recognition by phosphatidylinositol phosphate kinases is swapped by changing a single amino acid residue. J Biol Chem 277:5611-5619
68. Jarquin-Pardo M, Fitzpatrick A, Galiano FJ, First EA, Davis JN (2007) Phosphatidic acid regulates the affinity of the murine phosphatidylinositol 4-phosphate 5-kinase-Iβ for phosphatidylinositol-4-phosphate. J Cell Biochem 100:112-128
69. 2 level and inhibits FcγRIIA-mediated cell spreading and phagocytosis. Eur J Immunol 38:260-272
70. Lemmon MA (2008) Membrane recognition by phospholipidsbinding domains. Nature 9:99-111
71. Watt SA, Kular G, Fleming IN, Downes CP, Lucocq JM (2002) Subcellular localization of phosphatidylinositol 4, 5-bisphosphate using the pleckstrin homology domain of phospholipase Cδ1. Biochem J 363:657-666
72. Fairn GD, Ogata K, Botelho RJ, Stahl PD, Anderson RA, De Camilli P, Meyer T, Wodak S, Grinstein S (2009) An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis. J Cell Biol 187:701-714
73. Scott CC, Dobson W, Botelho RJ, Coady-Osberg N, Chavrier P, Knecht DA, Heath C, Stahl P, Grinstein S (2005) Phosphatidylinositol-4, 5-bisphosphate hydrolysis directs actin remodeling during phagocytosis. J Cell Biol 169:139-149
74. Wang YJ, Wang J, Sun HQ, Martinez M, Sun YX, Macia E, Kirchhausen T, Albanesi JP, Roth MG, Yin HL (2003) Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Cell 114:293-299
75. Levine TP, Munro S (2002) Targeting of Golgi-specific pleckstrin homology domains involves both PtdIns 4-kinasedependent and -independent components. Curr Biol 12:695-704
76. Godi A, Di Campli A, Konstantakopoulos A, Di Tullio G, Alessi DR, Kular GS, Daniele T, Marra P, Lucocq JM, De Matteis MA (2004) FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns (4) P. Nature Cell Biol 6:393-404
77. Balla A, Tuymetova G, Tsiomenko A, Varnai P, Balla T (2005) A plasma membrane pool of phosphatidylinositol 4-phosphate is generated by phosphatidylinositol 4-kinase type-IIIα: studies with the PH domains of the oxysterol binding protein and FAPP1. Mol Biol Cell 16:1282-1295
78. Tran D, Gascard P, Berthon B, Fukami K, Takenawa T, Giraud F, Claret M (1993) Cellular distribution of polyphosphoinositides in rat hepatocytes. Cell Signal 5:565-581
79. Gillooly DJ, Morrow IC, Lindsay M, Gould R, Bryant NJ, Gaullier JM, Parton RG, Stenmark H (2000) Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO J 19:4577-4588
80. Vieira OV, Verkade P, Manninen A, Simons K (2005) FAPP2 is involved in the transport of apical cargo in polarized MDCK cells. J Cell Biol 170:521-526
81. Wang J, Sun HQ, Macia E, Kirchhausen T, Watson H, Bonifacino JS, Yin HL (2007) PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal. Mol Biol Cell 18:2646-2655
82. D'Angelo G, Vicinanza M, Di Campli A, De Matteis MA (2008) The multiple roles of PtdIns (4) P-not just the precursor of PtdIns (4, 5) P2. J Cell Sci 121:1955-1963
83. Balla A, Kim YJ, Varnai P, Szentpetery Z, Knight Z, Shokat KM, Balla T (2008) Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIa. Mol Biol Cell 19:711-721
84. 2. Biochem J 422:23-35
85. Cockcroft S, Taylor JA, Judah JD (1985) Subcellular localisation of inositol lipid kinases in rat liver. Biochim Biophys Acta 845:163-170
86. Wong K, Meyers R, Cantley LC (1997) Subcellular locations of phosphatidylinositol 4-kinase isoforms. J Biol Chem 272:13236-13241
87. Barylko B, Gerber SH, Binns D, Grichine N, Khvotchev M, Südhof TC, Albanesi JP (2001) A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans. J Biol Chem 276:7705-7708
88. Wei YJ, Sun HQ, Yamamoto M, Wlodarski P, Kunii K, Martinez M, Barylko B, Albanesi JP, Yin HL (2002) Type II phosphatidylinositol 4-kinase β is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP. J Biol Chem 277:46586-46593
89. Balla A, Tuymetova G, Barshishat M, Geiszt M, Balla T (2002) Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments. J Biol Chem 277:20041-20050
90. Weixel KM, Blumental-Perry A, Watkins SC, Aridor M, Weisz OA (2005) Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases. J Biol Chem 280:10501-10508
91. Jung G, Wang J, Wlodarski P, Barylko B, Binns DD, Shu H, Yin HL, Albanesi JP (2008) Molecular determinants of activation and membrane targeting of phosphoinositol 4-kinase IIβ. Biochem J 409:501-509
92. 2+ signaling. J Cell Biol 167:1005-1010
93. Tolias KF, Cantley LC, Carpenter CL (1995) Rho family GTPases bind to phosphoinositide kinases. J Biol Chem 270:17656-17699
94. van Hennik PB, ten Klooster JP, Halstead JR, Voermans C, Anthony EC, Divecha N, Hordijk PL (2003) The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity. J Biol Chem 278:39166-39175
95. Oude Weernink PA, Meletiadis K, Hommeltenberg S, Hinz M, Ishihara H, Schmidt M, Jakobs KH (2004) Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42. J Biol Chem 279:7840-7849
96. Ren XD, Bokoch GM, Traynor-Kaplan A, Jenkins GH, Anderson RA, Schwartz MA (1996) Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells. Mol Biol Cell 7:435-442
97. Honda A, Nogami M, Yokozeki T, Yamazaki M, Nakamura H, Watanabe H, Kawamoto K, Nakayama K, Morris AJ, Frohman MA, Kanaho y (1999) Phosphatidylinositol 4-phosphate 5-kinase a is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell 99:521-532
98. Chong LD, Traynor-Kaplan A, Bokoch GM, Schwartz MA (1994) The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell 79:507-513
99. Chatah NE, Abrams CS (2001) G-protein-coupled receptor activation induces the membrane translocation and activation of phosphatidylinositol-4-phosphate 5-kinase Iα by a Rac- and Rho-dependent pathway. J Biol Chem 276:34059-34065
100. Yamazaki M, Miyazaki H, Watanabe H, Sasaki T, Maehama T, Frohman MA, Kanaho y (2002) Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling. J Biol Chem 277:17226-17230
101. Yang SA, Carpenter CL, Abrams CS (2004) Rho and Rhokinase mediate thrombin-induced phosphatidylinositol 4-phosphate 5-kinase trafficking in platelets. J Biol Chem 279:42331-42336
102. Heasman SJ, Ridley AJ (2009) Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 9:690-701
103. Abramovici H, Mojtabaie P, Parks RJ, Zhong XP, Koretzky GA, Topham MK, Gee SH (2009) Diacylglycerol kinase ζ regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. Mol Biol Cell 20:2049-2059
104. Luo B, Prescott SM, Topham MK (2004) Diacylglycerol kinase ζ regulates phosphatidylinositol 4-phosphate 5-kinase Ia by a novel mechanism. Cell Signal 16:91-897
105. Illenberger D, Walliser C, Nurnberg B, Diaz Lorente M, Gierschik P (2003) Specificity and structural requirements of phospholipase C-β stimulation by Rho GTPases versus G protein βγ dimers. J Biol Chem 278:3006-3014
106. 2 by Rac GTPases. J Biol Chem 280:38923-38931
107. 2. Mol Cell 34:223-233
108. Pratt SJ, Epple H, Ward M, Feng Y, Braga VM, Longmore GD (2005) The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol 168:813-824
109. Krauss M, Kinuta M, Wenk MR, De Camilli P, Takei K, Haucke V (2003) ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Iγ. J Cell Biol 162:113-124
110. Hiroyama M, Exton JH (2005) Localization and regulation of phospholipase D2 by ARF6. J Cell Biochem 95:149-164
111. Perez-Mansilla B, Ha VL, Justin N, Wilkins AJ, Carpenter CL, Thomas GM (2006) The differential regulation of phosphatidylinositol 4-phosphate 5-kinases and phospholipase D1 by ADP-ribosylation factors 1 and 6. Biochim Biophys Acta 1761:1429-1442
112. Divecha N, Roefs M, Halstead JR, D'Andrea S, Fernandez-Borga M, Oomen L, Saqib KM, Wakelam MJ, D'Santos C (2000) Interaction of the type Ia PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity. EMBO J 19:5440-5449
113. Skippen A, Jones DH, Morgan CP, Li M, Cockcroft S (2002) Mechanism of ADP ribosylation factor-stimulated phosphatidylinositol 4, 5-bisphosphate synthesis in HL60 cells. J Biol Chem 277:5823-5831
114. Aikawa Y, Martin TF (2003) ARF6 regulates a plasma membrane pool of phosphatidylinositol (4, 5) bisphosphate required for regulated exocytosis. J Cell Biol 162:647-659
115. Begle A, Tryoen-Toth P, de Barry J, Bader MF, Vitale N (2009) ARF6 regulates the synthesis of fusogenic lipids for calciumregulated exocytosis in neuroendocrine cells. J Biol Chem 284:4836-4845
116. Santy LC, Ravichandran KS, Casanova JE (2005) The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1. Curr Biol 15:1749-1754
117. Myers KR, Casanova JE (2008) Regulation of actin cytoskeleton dynamics by Arf-family GTPases. Trends Cell Biol 18:184-192
118. Gingras AR, Bate N, Goult BT, Hazelwood L, Canestrelli I, Grossmann JG, Liu H, Putz NS, Roberts GC, Volkmann N, Hanein D, Barsukov IL, Critchley DR (2008) The structure of the C-terminal actin-binding domain of talin. EMBO J 27:458-469
119. Gingras AR, Ziegler WH, Bobkov AA, Joyce MG, Fasci D, Himmel M, Rothemund S, Ritter A, Grossmann JG, Patel B, Bate N, Goult BT, Emsley J, Barsukov IL, Roberts GC, Liddington RC, Ginsberg MH, Critchley DR (2009) Structural determinants of integrin binding to the talin rod. J Biol Chem 284:8866-8876
120. Barsukov IL, Prescot A, Bate N, Patel B, Floyd DN, Bhanji N, Bagshaw CR, Letinic K, Di Paolo G, De Camilli P, Roberts GC, Critchley DR (2003) Phosphatidylinositol phosphate kinase type 1γ and β1-integrin cytoplasmic domain bind to the same region in the talin FERM domain. J Biol Chem 278:31202-31209
121. de Pereda JM, Wegener KL, Santelli E, Bate N, Ginsberg MH, Critchley DR, Campbell ID, Liddington RC (2005) Structural basis for phosphatidylinositol phosphate kinase type Iγ binding to talin at focal adhesions. J Biol Chem 280:8381-8386
122. Kong X, Wang X, Misra S, Qin J (2006) Structural basis for the phosphorylation-regulated focal adhesion targeting of type Iγ phosphatidylinositol phosphate kinase (PIPKIγ) by talin. J Mol Biol 359:47-54
123. Hamada K, Shimizu T, Matsui T, Tsukita S, Hakoshima T (2000) Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. EMBO J 19:4449-4462
124. Martel V, Racaud-Sultan C, Dupe S, Marie C, Paulhe F, Galmiche A, Block MR, Albiges-Rizo C (2001) Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides. J Biol Chem 276:21217-21227
125. 2- and membrane proximal integrin-binding motifs in the talin head control β3-integrin clustering. J Cell Biol 187:715-731
126. Bairstow SF, Ling K, Anderson RA (2002) Phosphatidylinositol phosphate kinase type Iγdirectly associates with and regulates Shp-1 tyrosine phosphatase. J Biol Chem 280:23884-23891
127. Sun Y, Ling K, Wagoner MP, Anderson RA (2007) Type Iγ phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration. J Cell Biol 178:297-308
128. Tanentzapf G, Brown NH (2006) An interaction between integrin and the talin FERM domain mediates integrin activation but not linkage to the cytoskeleton. Nat Cell Biol 8:601-606
129. Cheung TY, Fairchild MJ, Zarivach R, Tanentzapf G, Van Petegem F (2009) Crystal structure of the talin integrin binding domain 2. J Mol Biol 387:787-793
130. 2 synthesizing enzyme at the synapse. Neuron 32:79-88
131. Kahlfeldt N, Vahedi-Faridi A, Koo SJ, Scháfer JG, Krainer G, Keller S, Saenger W, Krauss M, Haucke V (2010) Molecular basis for association of PIPKIγ-p90 with clathrin adaptor AP-2. J Biol Chem 285:2734-2749
132. Thieman JR, Mishra SK, Ling K, Doray B, Anderson RA, Traub LM (2009) Clathrin regulates the association of PIPKIγ661 with the AP-2 adaptor β2 appendage. J Biol Chem 284:13924-13939
133. GTP recruits the AP-2 adaptor complex to membranes. J Biol Chem 280:21661-21666
134. Jung N, Haucke V (2007) Clathrin-mediated endocytosis at synapses. Traffic 81129-11136
135. Barbieri MA, Heath CM, Peters EM, Wells A, Davis JN, Stahl PD (2001) Phosphatidylinositol-4-phosphate 5-kinase-1β is essential for epidermal growth factor receptor-mediated endocytosis. J Biol Chem 276:47212-47216
136. Botelho RJ, Teruel M, Dierckman R, Anderson R, Wells A, York JD, Meyer T, Grinstein S (2000) Localized biphasic changes in phosphatidylinositol-4, 5-bisphosphate at sites of phagocytosis. J Cell Biol 151:1353-1368
137. Golebiewska U, Nyako M, Woturski W, Zaitseva I, McLaughlin S (2008) Diffusion coefficient of fluorescent phosphatidylinositol 4, 5-bisphosphate in the plasma membrane of cells. Mol Biol Cell 19:1663-1669
138. Wagner ML, Tamm LK (2001) Reconstituted syntaxin1a/SNAP25 interacts with negatively charged lipids as measured by lateral diffusion in planar supported bilayers. Biophys J 81:266-275
139. 2), but not monovalent (PS), acidic lipids. Biophys J 91:588-599
140. 2 hydrolysis inhibits cortical actin dynamics: regulation at a global but not at a micrometer scale. Mol Biol Cell 13:3257-3267
141. Haugh JM, Codazzi F, Teruel M, Meyer T (2000) Spatial sensing in fibroblasts mediated by 3' phosphoinositides. J Cell Biol 151:1269-1280
142. 2 and proteins: interactions, organization, and information flow. Annu Rev Biophys Biomol Struct 31:151-175
143. Cho H, Kim YA, Yoon JY, Lee D, Kim JH, Lee SH, Ho WK (2005) Low mobility of phosphatidylinositol 4, 5-bisphosphate underlies receptor specificity of Gq-mediated ion channel regulation in atrial myocytes. Proc Natl Acad Sci USA 102:15241-15246
144. Cho H, Kim YA, Ho WK (2006) Phosphate number and acyl chain length determine the subcellular location and lateral mobility of phosphoinositides. Mol Cells 22:97-103
145. 2 signals: when, where, and how? Pflugers Arch 455:55-67
146. Stefanova I, Horejsi V, Ansotegui IJ, Knapp W, Stockinger H (1991) GPI-anchored cell-surface molecules complexed to protein tyrosine kinases. Science 254:1016-1019
147. Fra AM, Williamson E, Simons K, Parton RG (1994) Detergentinsoluble glycolipid microdomains in lymphocytes in the absence of caveolae. J Biol Chem 269:30745-30748
148. Simons K, Ikonen e (1997) Functional rafts in cell membranes. Nature 387:569-572
149. Brown DA, London e (1997) Structure of detergent-resistant membrane domains: does phase separation occur in biological membranes? Biochem Biophys Res Commun 240:1-7
150. Fridriksson EK, Shipkova PA, Sheets ED, Holowka D, Baird B, McLafferty FW (1999) Quantitative analysis of phospholipids in functionally important membrane domains from RBL-2H3 mast cells using tandem high-resolution mass spectrometry. Biochemistry 38:8056-8063
151. Brown DA, Rose JK (1992) Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface. Cell 68:344-533
152. Ahmed SN, Brown DA, London e (1997) On the origin of sphingolipid/ cholesterol-rich detergent-insoluble cell membranes: physiological concentrations of cholesterol and sphingolipid induce formation of a detergent-insoluble, liquidordered lipid phase in model membranes. Biochemistry 36:10944-10953
153. Montixi C, Langlet C, Bernard AM, Thimonier J, Dubois C, Wurbel MA, Chauvin JP, Pierres M, He HT (1998) Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. EMBO J 17:5334-5348
154. Sheets ED, Holowka D, Baird B (1999) Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of Fcε RI and their association with detergent-resistant membranes. J Cell Biol 145:877-887
155. Hope HR, Pike LJ (1996) Phosphoinositides and phosphoinositide-utilizing
156. Pike LJ, Casey L (1996) Localization and turnover of phosphatidylinositol 4, 5-bisphosphate in caveolin-enriched membrane domains. J Biol Chem 271:6453-26456
157. Pike LJ, Miller JM (1998) Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover. J Biol Chem 273:22298-22304
158. Waugh MG, Lawson D, Tan SK, Hsuan JJ (1998) Phosphatidylinositol 4-phosphate synthesis in immunoisolated caveolaelike vesicles and low buoyant density non-caveolar membranes. J Biol Chem 273:17115-17121
159. Liu Y, Casey L, Pike LJ (1998) Compartmentalization of phosphatidylinositol 4, 5-bisphosphate in low-density membrane domains in the absence of caveolin. Biochem Biophys Res Commun 245:684-690
160. Hur EM, Park YS, Lee BD, Jang IH, Kim HS, Kim TD, Suh PG, Ryu SH, Kim KT (2004) Sensitization of epidermal growth factor-induced signaling by bradykinin is mediated by c-Src. Implications for a role of lipid microdomains. J Biol Chem 279:5852-5860
161. Bodin S, Giuriato S, Ragab J, Humbel BM, Viala C, Vieu C, Chap H, Payrastre B (2001) Production of phosphatidylinositol 3, 4, 5-trisphosphate and phosphatidic acid in platelet rafts: evidence for a critical role of cholesterol-enriched domains in human platelet activation. Biochemistry 40:15209-15290
162. Heerklotz H (2002) Triton promotes domain formation in lipid raft mixtures. Biophys J 83:2693-2701
163. Korzeniowski M, Kwiatkowska K, Sobota A (2003) Insights into the association of FcγRII and TCR with detergent-resistant membrane domains: isolation of the domains in detergent-free density gradients facilitates membrane fragment reconstitution. Biochemistry 42:5358-5367
164. Shogomori H, Brown DA (2003) Use of detergents to study membrane rafts: the good, the bad, and the ugly. J Biol Chem 384:1259-1263
165. Kwik J, Boyle S, Fooksman D, Margolis L, Sheetz MP, Edidin M (2003) Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4, 5-bisphosphate-dependent organization of cell actin. Proc Natl Acad Sci USA 100:13964-13969
166. 2 signaling in lipid domains: a critical re-evaluation. EMBO J 24:1664-1673
167. 2 in baby hamster kidney and Chinese hamster ovary cell plasmalemma. J Membr Biol 220:53-67
168. Janes PW, Ley SC, Magee AI (1999) Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J Cell Biol 147:447-461
169. Holowka D, Sheets ED, Baird B (2000) Interactions between FcεRI and lipid raft components are regulated by the actin cytoskeleton. J Cell Sci 113:1009-1019
170. Wilson BS, Pfeiffer JR, Surviladze Z, Gaudet EA, Oliver JM (2001) High-resolution mapping of mast cell membranes reveals primary and secondary domains of FcεRI and LAT. J Cell Biol 154:645-658
171. Kwiatkowska K, Frey J, Sobota A (2003) Phosphorylation of FcγRIIA is required for the receptor-induced actin rearrangement and capping: the role of membrane rafts. J Cell Sci 116:537-550
172. 2 synthesis: importance for calcium signaling and PI3K activity. Immunity 19:669-678
173. Foster LJ, De Hoog CL, Mann M (2003) Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors. Proc Natl Acad Sci USA 100:5813-5818
174. Parmryd I, Adler J, Patel R, Magee AI (2003) Imaging metabolism of phosphatidylinositol 4, 5-bisphosphate in T-cell GM1-enriched domains containing Ras proteins. Exp Cell Res 285:27-38
175. Strzelecka-Kiliszek A, Korzeniowski M, Kwiatkowska K, Mrozinska K, Sobota A (2004) Activated FcγRII and signalling molecules revealed in rafts by ultra-structural observations of plasma-membrane sheets. Mol Membr Biol 21:101-108
176. Korzeniowski M, Shakor AB, Makowska A, Drzewiecka A, Bielawska A, Kwiatkowska K, Sobota A (2007) FcγRII activation induces cell surface ceramide production which participates in the assembly of the receptor signaling complex. Cell Physiol Biochem 20:347-356
177. Raucher D, Stauffer T, Chen W, Shen K, Guo S, York JD, Sheetz MP, Meyer T (2000) Phosphatidylinositol 4, 5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell 100:221-228
178. Hagelberg C, Allan D (1990) Restricted diffusion of integral membrane proteins and polyphosphoinositides leads to their depletion in microvesicles released from human erythrocytes. Biochem J 271:831-834
179. Gambhir A, Hangyas-Mihalyne G, Zaitseva I, Cafiso DS, Wang J, Murray D, Pentyala SN, Smith SO, McLaughlin S (2004) Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins. Biophys J 86:2188-2207
180. McLaughlin S, Murray D (2005) Plasma membrane phosphoinositide organization by protein electrostatics. Nature 43:605-611
181. Tong J, Nguyen L, Vidal A, Simon SA, Skene JH, McIntosh TJ (2008) Role of GAP-43 in sequestering phosphatidylinositol 4, 5-bisphosphate to raft bilayers. Biophys J 94:125-133
182. 2 at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J Cell Biol 149:455-1471
183. 2-dependent microdomain assemblies capture microtubules to promote and control leading edge motility. J Cell Biol 169:151-165