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Volumn 26, Issue 5, 2014, Pages 493-501

The role of T cells in systemic lupus erythematosus: An update

Author keywords

Interleukin 2; systemic lupus erythematosus; T cells

Indexed keywords

DNA; INTERLEUKIN 2; MICRORNA; T LYMPHOCYTE RECEPTOR; HISTONE; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 84905495798     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0000000000000082     Document Type: Review
Times cited : (50)

References (88)
  • 1
    • 82555196095 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Tsokos GC. Systemic lupus erythematosus. N Engl J Med 2011; 365:2110-2121.
    • (2011) N Engl J Med , vol.365 , pp. 2110-2121
    • Tsokos, G.C.1
  • 2
    • 84875876283 scopus 로고    scopus 로고
    • New therapeutics in systemic lupus erythematosus
    • Paz Z, Tsokos GC. New therapeutics in systemic lupus erythematosus. Curr Opin Rheumatol 2013; 25:297-303.
    • (2013) Curr Opin Rheumatol , vol.25 , pp. 297-303
    • Paz, Z.1    Tsokos, G.C.2
  • 3
    • 0034744286 scopus 로고    scopus 로고
    • Fc epsilon receptor type i gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus
    • Enyedy EJ, Nambiar MP, Liossis SN, et al. Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus. Arthritis Rheum 2001; 44:1114-1121.
    • (2001) Arthritis Rheum , vol.44 , pp. 1114-1121
    • Enyedy, E.J.1    Nambiar, M.P.2    Liossis, S.N.3
  • 4
    • 0036164354 scopus 로고    scopus 로고
    • Abnormal expression of various molecular forms and distribution of T cell receptor zeta chain in patients with systemic lupus erythematosus
    • Nambiar MP, Enyedy EJ, Fisher CU, et al. Abnormal expression of various molecular forms and distribution of T cell receptor zeta chain in patients with systemic lupus erythematosus. Arthritis Rheum 2002; 46:163-174.
    • (2002) Arthritis Rheum , vol.46 , pp. 163-174
    • Nambiar, M.P.1    Enyedy, E.J.2    Fisher, C.U.3
  • 5
    • 0032036481 scopus 로고    scopus 로고
    • Altered pattern of TCR/CD3- mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus: Deficient expression of the T cell receptor zeta chain
    • Liossis SN, Ding XZ, Dennis GJ, Tsokos GC. Altered pattern of TCR/CD3- mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus: deficient expression of the T cell receptor zeta chain. J Clin Invest 1998; 101:1448-1457.
    • (1998) J Clin Invest , vol.101 , pp. 1448-1457
    • Liossis, S.N.1    Ding, X.Z.2    Dennis, G.J.3    Tsokos, G.C.4
  • 6
    • 0037443553 scopus 로고    scopus 로고
    • Forced expression of the Fc receptor gamma-chain renders human T cells hyperresponsive to TCR/CD3 stimulation
    • Nambiar MP, Fisher CU, Kumar A, et al. Forced expression of the Fc receptor gamma-chain renders human T cells hyperresponsive to TCR/CD3 stimulation. J Immunol 2003; 170:2871-2876.
    • (2003) J Immunol , vol.170 , pp. 2871-2876
    • Nambiar, M.P.1    Fisher, C.U.2    Kumar, A.3
  • 7
    • 0038342830 scopus 로고    scopus 로고
    • Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor/ CD3-induced interleukin-2 production in patients with systemic lupus erythematosus
    • Nambiar MP, Fisher CU, Warke VG, et al. Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor/ CD3-induced interleukin-2 production in patients with systemic lupus erythematosus. Arthritis Rheum 2003; 48:1948-1955.
    • (2003) Arthritis Rheum , vol.48 , pp. 1948-1955
    • Nambiar, M.P.1    Fisher, C.U.2    Warke, V.G.3
  • 8
    • 77954229590 scopus 로고    scopus 로고
    • Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice
    • Deng GM, Liu L, Bahjat FR, et al. Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice. Arthritis Rheum 2010; 62:2086-2092.
    • (2010) Arthritis Rheum , vol.62 , pp. 2086-2092
    • Deng, G.M.1    Liu, L.2    Bahjat, F.R.3
  • 9
    • 80053286823 scopus 로고    scopus 로고
    • Abnormalities of T cell signaling in systemic lupus erythematosus
    • Moulton VR, Tsokos GC. Abnormalities of T cell signaling in systemic lupus erythematosus. Arthritis Res Ther 2011; 13:207.
    • (2011) Arthritis Res Ther , vol.13 , pp. 207
    • Moulton, V.R.1    Tsokos, G.C.2
  • 10
    • 77951234994 scopus 로고    scopus 로고
    • Alternative splicing factor/splicing factor 2 regulates the expression of the zeta subunit of the human T cell receptor-associated CD3 complex
    • Moulton VR, Tsokos GC. Alternative splicing factor/splicing factor 2 regulates the expression of the zeta subunit of the human T cell receptor-associated CD3 complex. J Biol Chem 2010; 285:12490-12496.
    • (2010) J Biol Chem , vol.285 , pp. 12490-12496
    • Moulton, V.R.1    Tsokos, G.C.2
  • 11
    • 84873176790 scopus 로고    scopus 로고
    • Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription
    • Moulton VR, Grammatikos AP, Fitzgerald LM, Tsokos GC. Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription. Proc Natl Acad Sci U S A 2013; 110:1845-1850.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 1845-1850
    • Moulton, V.R.1    Grammatikos, A.P.2    Fitzgerald, L.M.3    Tsokos, G.C.4
  • 12
    • 2142710163 scopus 로고    scopus 로고
    • Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus
    • Jury EC, Kabouridis PS, Flores-Borja F, et al. Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus. J Clin Invest 2004; 113:1176-1187.
    • (2004) J Clin Invest , vol.113 , pp. 1176-1187
    • Jury, E.C.1    Kabouridis, P.S.2    Flores-Borja, F.3
  • 13
    • 2942586874 scopus 로고    scopus 로고
    • Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus
    • Krishnan S, Nambiar MP, Warke VG, et al. Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus. J Immunol 2004; 172:7821-7831.
    • (2004) J Immunol , vol.172 , pp. 7821-7831
    • Krishnan, S.1    Nambiar, M.P.2    Warke, V.G.3
  • 14
    • 84954358117 scopus 로고    scopus 로고
    • Lipid rafts and T-lymphocyte function: Implications for autoimmunity
    • Kabouridis PS, Jury EC. Lipid rafts and T-lymphocyte function: implications for autoimmunity. FEBS Lett 2008; 582:3711-3718.
    • (2008) FEBS Lett , vol.582 , pp. 3711-3718
    • Kabouridis, P.S.1    Jury, E.C.2
  • 15
    • 56149099718 scopus 로고    scopus 로고
    • Cholera toxin B accelerates disease progression in lupus-prone mice by promoting lipid raft aggregation
    • Deng GM, Tsokos GC. Cholera toxin B accelerates disease progression in lupus-prone mice by promoting lipid raft aggregation. J Immunol 2008; 181:4019-4026.
    • (2008) J Immunol , vol.181 , pp. 4019-4026
    • Deng, G.M.1    Tsokos, G.C.2
  • 16
    • 84893847951 scopus 로고    scopus 로고
    • Lipids rule: Resetting lipid metabolism restores T cell function in systemic lupus erythematosus
    • Kidani Y, Bensinger SJ. Lipids rule: resetting lipid metabolism restores T cell function in systemic lupus erythematosus. J Clin Invest 2014; 124:482-485.
    • (2014) J Clin Invest , vol.124 , pp. 482-485
    • Kidani, Y.1    Bensinger, S.J.2
  • 17
    • 0029041568 scopus 로고
    • Transcriptional regulation of the IL-2 gene
    • Jain J, Loh C, Rao A. Transcriptional regulation of the IL-2 gene. Curr Opin Immunol 1995; 7:333-342.
    • (1995) Curr Opin Immunol , vol.7 , pp. 333-342
    • Jain, J.1    Loh, C.2    Rao, A.3
  • 18
    • 3042534462 scopus 로고    scopus 로고
    • Transcriptional regulation of interleukin 2 in SLE T cells
    • Tenbrock K, Tsokos GC. Transcriptional regulation of interleukin 2 in SLE T cells. Int Rev Immunol 2004; 23:333-345.
    • (2004) Int Rev Immunol , vol.23 , pp. 333-345
    • Tenbrock, K.1    Tsokos, G.C.2
  • 19
    • 0019948507 scopus 로고
    • Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus
    • Alcocer-Varela J, Alarcon-Segovia D. Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus. J Clin Invest 1982; 69:1388-1392.
    • (1982) J Clin Invest , vol.69 , pp. 1388-1392
    • Alcocer-Varela, J.1    Alarcon-Segovia, D.2
  • 20
    • 0020546709 scopus 로고
    • Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE)
    • Linker-Israeli M, Bakke AC, Kitridou RC, et al. Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE). J Immunol 1983; 130:2651-2655.
    • (1983) J Immunol , vol.130 , pp. 2651-2655
    • Linker-Israeli, M.1    Bakke, A.C.2    Kitridou, R.C.3
  • 21
    • 60149085254 scopus 로고    scopus 로고
    • A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells
    • Yu A, Zhu L, Altman NH, Malek TR. A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells. Immunity 2009; 30:204-217.
    • (2009) Immunity , vol.30 , pp. 204-217
    • Yu, A.1    Zhu, L.2    Altman, N.H.3    Malek, T.R.4
  • 22
    • 33846900430 scopus 로고    scopus 로고
    • Deficient CD4+CD25 high T regulatory cell function in patients with active systemic lupus erythematosus
    • Valencia X, Yarboro C, Illei G, Lipsky PE. Deficient CD4+CD25 high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 2007; 178:2579-2588.
    • (2007) J Immunol , vol.178 , pp. 2579-2588
    • Valencia, X.1    Yarboro, C.2    Illei, G.3    Lipsky, P.E.4
  • 23
    • 33845948381 scopus 로고    scopus 로고
    • IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+CD25+T cell regulatory functions
    • Wan S, Xia C, Morel L. IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+CD25+T cell regulatory functions. J Immunol 2007; 178:271-279.
    • (2007) J Immunol , vol.178 , pp. 271-279
    • Wan, S.1    Xia, C.2    Morel, L.3
  • 24
    • 0034633683 scopus 로고    scopus 로고
    • IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice
    • Marks-Konczalik J, Dubois S, Losi JM, et al. IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice. Proc Natl Acad Sci U S A 2000; 97:11445-11450.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 11445-11450
    • Marks-Konczalik, J.1    Dubois, S.2    Losi, J.M.3
  • 25
    • 16844376445 scopus 로고    scopus 로고
    • Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
    • Juang YT, Wang Y, Solomou EE, et al. Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV. J Clin Invest 2005; 115:996-1005.
    • (2005) J Clin Invest , vol.115 , pp. 996-1005
    • Juang, Y.T.1    Wang, Y.2    Solomou, E.E.3
  • 26
    • 80052731499 scopus 로고    scopus 로고
    • A novel intronic cAMP response element modulator (CREM) promoter is regulated by activator protein-1 (AP-1) and accounts for altered activation-induced CREM expression in T cells from patients with systemic lupus erythematosus
    • Rauen T, Benedyk K, Juang YT, et al. A novel intronic cAMP response element modulator (CREM) promoter is regulated by activator protein-1 (AP-1) and accounts for altered activation-induced CREM expression in T cells from patients with systemic lupus erythematosus. J Biol Chem 2011; 286:32366-32372.
    • (2011) J Biol Chem , vol.286 , pp. 32366-32372
    • Rauen, T.1    Benedyk, K.2    Juang, Y.T.3
  • 27
    • 83355166950 scopus 로고    scopus 로고
    • CAMP-responsive element modulator (CREM) alpha protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: Implications in systemic lupus erythematosus
    • Hedrich CM, Rauen T, Tsokos GC. cAMP-responsive element modulator (CREM) alpha protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus. J Biol Chem 2011; 286:43429-43436.
    • (2011) J Biol Chem , vol.286 , pp. 43429-43436
    • Hedrich, C.M.1    Rauen, T.2    Tsokos, G.C.3
  • 28
    • 79551680278 scopus 로고    scopus 로고
    • Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin- dependent protein kinase type IV
    • Ichinose K, Juang YT, Crispin JC, et al. Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin- dependent protein kinase type IV. Arthritis Rheum 2011; 63:523-529.
    • (2011) Arthritis Rheum , vol.63 , pp. 523-529
    • Ichinose, K.1    Juang, Y.T.2    Crispin, J.C.3
  • 29
    • 79961088157 scopus 로고    scopus 로고
    • Induction of PP2A Bbeta, a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus
    • Crispin JC, Apostolidis SA, Finnell MI, Tsokos GC. Induction of PP2A Bbeta, a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus. Proc Natl Acad Sci U S A 2011; 108:12443-12448.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 12443-12448
    • Crispin, J.C.1    Apostolidis, S.A.2    Finnell, M.I.3    Tsokos, G.C.4
  • 31
    • 4344718846 scopus 로고    scopus 로고
    • Cyclic adenosine 5'-monophosphate response element modulator is responsible for the decreased expression of c-fos and activator protein-1 binding in T cells from patients with systemic lupus erythematosus
    • Kyttaris VC, Juang YT, Tenbrock K, et al. Cyclic adenosine 5'-monophosphate response element modulator is responsible for the decreased expression of c-fos and activator protein-1 binding in T cells from patients with systemic lupus erythematosus. J Immunol 2004; 173:3557-3563.
    • (2004) J Immunol , vol.173 , pp. 3557-3563
    • Kyttaris, V.C.1    Juang, Y.T.2    Tenbrock, K.3
  • 32
    • 0029862164 scopus 로고    scopus 로고
    • Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes
    • Koshy M, Berger D, Crow MK. Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes. J Clin Invest 1996; 98:826-837.
    • (1996) J Clin Invest , vol.98 , pp. 826-837
    • Koshy, M.1    Berger, D.2    Crow, M.K.3
  • 33
    • 0029913381 scopus 로고    scopus 로고
    • Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production
    • Desai-Mehta A, Lu L, Ramsey-Goldman R, Datta SK. Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production. J Clin Invest 1996; 97:2063-2073.
    • (1996) J Clin Invest , vol.97 , pp. 2063-2073
    • Desai-Mehta, A.1    Lu, L.2    Ramsey-Goldman, R.3    Datta, S.K.4
  • 34
    • 0037333857 scopus 로고    scopus 로고
    • A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis
    • Boumpas DT, Furie R, Manzi S, et al. A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Arthritis Rheum 2003; 48:719-727.
    • (2003) Arthritis Rheum , vol.48 , pp. 719-727
    • Boumpas, D.T.1    Furie, R.2    Manzi, S.3
  • 35
    • 2942711587 scopus 로고    scopus 로고
    • Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients
    • Sidiropoulos PI, Boumpas DT. Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients. Lupus 2004; 13:391-397.
    • (2004) Lupus , vol.13 , pp. 391-397
    • Sidiropoulos, P.I.1    Boumpas, D.T.2
  • 36
    • 75749090357 scopus 로고    scopus 로고
    • Key role of ERK pathway signaling in lupus
    • Gorelik G, Richardson B. Key role of ERK pathway signaling in lupus. Autoimmunity 2010; 43:17-22.
    • (2010) Autoimmunity , vol.43 , pp. 17-22
    • Gorelik, G.1    Richardson, B.2
  • 37
    • 38449104652 scopus 로고    scopus 로고
    • Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazineinduced lupus
    • Gorelik G, Fang JY, Wu A, et al. Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazineinduced lupus. J Immunol 2007; 179:5553-5563.
    • (2007) J Immunol , vol.179 , pp. 5553-5563
    • Gorelik, G.1    Fang, J.Y.2    Wu, A.3
  • 38
    • 39749157996 scopus 로고    scopus 로고
    • Defective expression of Ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus
    • Yasuda S, Stevens RL, Terada T, et al. Defective expression of Ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus. J Immunol 2007; 179:4890-4900.
    • (2007) J Immunol , vol.179 , pp. 4890-4900
    • Yasuda, S.1    Stevens, R.L.2    Terada, T.3
  • 39
    • 0035096761 scopus 로고    scopus 로고
    • Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients
    • Deng C, Kaplan MJ, Yang J, et al. Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients. Arthritis Rheum 2001; 44:397-407.
    • (2001) Arthritis Rheum , vol.44 , pp. 397-407
    • Deng, C.1    Kaplan, M.J.2    Yang, J.3
  • 40
    • 2642556447 scopus 로고    scopus 로고
    • Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors
    • Oelke K, Lu Q, Richardson D, et al. Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors. Arthritis Rheum 2004; 50:1850-1860.
    • (2004) Arthritis Rheum , vol.50 , pp. 1850-1860
    • Oelke, K.1    Lu, Q.2    Richardson, D.3
  • 41
    • 33846536952 scopus 로고    scopus 로고
    • Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus
    • Li Y, Harada T, Juang YT, et al. Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus. J Immunol 2007; 178:1938-1947.
    • (2007) J Immunol , vol.178 , pp. 1938-1947
    • Li, Y.1    Harada, T.2    Juang, Y.T.3
  • 42
    • 77956361520 scopus 로고    scopus 로고
    • Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice
    • Biswas PS, Gupta S, Chang E, et al. Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. J Clin Invest 2010; 120:3280-3295.
    • (2010) J Clin Invest , vol.120 , pp. 3280-3295
    • Biswas, P.S.1    Gupta, S.2    Chang, E.3
  • 43
    • 84893362864 scopus 로고    scopus 로고
    • Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL/Mp-Fas lpr mice
    • Fujita Y, Fujii T, Mimori T, et al. Deficient leptin signaling ameliorates systemic lupus erythematosus lesions in MRL/Mp-Fas lpr mice. J Immunol 2014; 192:979-984.
    • (2014) J Immunol , vol.192 , pp. 979-984
    • Fujita, Y.1    Fujii, T.2    Mimori, T.3
  • 44
    • 84875464349 scopus 로고    scopus 로고
    • Cutting edge: Leptin-induced RORgammat expression in CD4+ T cells promotes Th17 responses in systemic lupus erythematosus
    • Yu Y, Liu Y, Shi FD, et al. Cutting edge: leptin-induced RORgammat expression in CD4+ T cells promotes Th17 responses in systemic lupus erythematosus. J Immunol 2013; 190:3054-3058.
    • (2013) J Immunol , vol.190 , pp. 3054-3058
    • Yu, Y.1    Liu, Y.2    Shi, F.D.3
  • 45
    • 70449719356 scopus 로고    scopus 로고
    • Human TCR-alpha beta+ CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype
    • Crispin JC, Tsokos GC. Human TCR-alpha beta+ CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype. J Immunol 2009; 183:4675-4681.
    • (2009) J Immunol , vol.183 , pp. 4675-4681
    • Crispin, J.C.1    Tsokos, G.C.2
  • 46
    • 58849162766 scopus 로고    scopus 로고
    • Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys
    • Crispin JC, Oukka M, Bayliss G, et al. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol 2008; 181:8761-8766.
    • (2008) J Immunol , vol.181 , pp. 8761-8766
    • Crispin, J.C.1    Oukka, M.2    Bayliss, G.3
  • 47
    • 64049096371 scopus 로고    scopus 로고
    • FAS-L, IL-10, and double-negative CD4- CD8- TCR alpha/beta+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function
    • Magerus-Chatinet A, Stolzenberg MC, Loffredo MS, et al. FAS-L, IL-10, and double-negative CD4- CD8- TCR alpha/beta+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function. Blood 2009; 113:3027-3030.
    • (2009) Blood , vol.113 , pp. 3027-3030
    • Magerus-Chatinet, A.1    Stolzenberg, M.C.2    Loffredo, M.S.3
  • 48
    • 0024341842 scopus 로고
    • T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis
    • Shivakumar S, Tsokos GC, Datta SK. T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis. J Immunol 1989; 143:103-112.
    • (1989) J Immunol , vol.143 , pp. 103-112
    • Shivakumar, S.1    Tsokos, G.C.2    Datta, S.K.3
  • 49
    • 84887125401 scopus 로고    scopus 로고
    • CAMP-responsive element modulator alpha (CREMalpha) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease
    • Hedrich CM, Rauen T, Crispin JC, et al. cAMP-responsive element modulator alpha (CREMalpha) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease. J Biol Chem 2013; 288:31880-31887.
    • (2013) J Biol Chem , vol.288 , pp. 31880-31887
    • Hedrich, C.M.1    Rauen, T.2    Crispin, J.C.3
  • 50
    • 84893122562 scopus 로고    scopus 로고
    • CAMP responsive element modulator (CREM) alpha mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells
    • Hedrich CM, Crispin JC, Rauen T, et al. cAMP responsive element modulator (CREM) alpha mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells. J Biol Chem 2014; 289:2361-2370.
    • (2014) J Biol Chem , vol.289 , pp. 2361-2370
    • Hedrich, C.M.1    Crispin, J.C.2    Rauen, T.3
  • 51
    • 0036024627 scopus 로고    scopus 로고
    • Characterization of CD3+ CD4- CD8- (double negative) T cells in patients with systemic lupus erythematosus: Production of IL-4
    • Dean GS, Anand A, Blofeld A, et al. Characterization of CD3+ CD4- CD8- (double negative) T cells in patients with systemic lupus erythematosus: production of IL-4. Lupus 2002; 11:501-507.
    • (2002) Lupus , vol.11 , pp. 501-507
    • Dean, G.S.1    Anand, A.2    Blofeld, A.3
  • 52
    • 0032529216 scopus 로고    scopus 로고
    • TCR ligation on CD8+ T cells creates double-negative cells in vivo
    • Mehal WZ, Crispe IN. TCR ligation on CD8+ T cells creates double-negative cells in vivo. J Immunol 1998; 161:1686-1693.
    • (1998) J Immunol , vol.161 , pp. 1686-1693
    • Mehal, W.Z.1    Crispe, I.N.2
  • 53
    • 0036024625 scopus 로고    scopus 로고
    • Characterization of CD3+ CD4- CD8- (double negative) T cells in patients with systemic lupus erythematosus: Activation markers
    • Anand A, Dean GS, Quereshi K, et al. Characterization of CD3+ CD4- CD8- (double negative) T cells in patients with systemic lupus erythematosus: activation markers. Lupus 2002; 11:493-500.
    • (2002) Lupus , vol.11 , pp. 493-500
    • Anand, A.1    Dean, G.S.2    Quereshi, K.3
  • 55
    • 66049151440 scopus 로고    scopus 로고
    • Th17 and natural Treg cell population dynamics in systemic lupus erythematosus
    • Yang J, Chu Y, Yang X, et al. Th17 and natural Treg cell population dynamics in systemic lupus erythematosus. Arthritis Rheum 2009; 60:1472-1483.
    • (2009) Arthritis Rheum , vol.60 , pp. 1472-1483
    • Yang, J.1    Chu, Y.2    Yang, X.3
  • 56
    • 70349238893 scopus 로고    scopus 로고
    • The role of IL-23/IL-17 axis in lupus nephritis
    • Zhang Z, Kyttaris VC, Tsokos GC. The role of IL-23/IL-17 axis in lupus nephritis. J Immunol 2009; 183:3160-3169.
    • (2009) J Immunol , vol.183 , pp. 3160-3169
    • Zhang, Z.1    Kyttaris, V.C.2    Tsokos, G.C.3
  • 57
    • 70449729971 scopus 로고    scopus 로고
    • CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis
    • Steinmetz OM, Turner JE, Paust HJ, et al. CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis. J Immunol 2009; 183: 4693-4704.
    • (2009) J Immunol , vol.183 , pp. 4693-4704
    • Steinmetz, O.M.1    Turner, J.E.2    Paust, H.J.3
  • 58
    • 54549100120 scopus 로고    scopus 로고
    • Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells
    • Zhang F, Meng G, Strober W. Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat Immunol 2008; 9:1297-1306.
    • (2008) Nat Immunol , vol.9 , pp. 1297-1306
    • Zhang, F.1    Meng, G.2    Strober, W.3
  • 59
    • 83355166923 scopus 로고    scopus 로고
    • CAMP-responsive element modulator (CREM) alpha protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus
    • Rauen T, Hedrich CM, Juang YT, et al. cAMP-responsive element modulator (CREM) alpha protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus. J Biol Chem 2011; 286:43437-43446.
    • (2011) J Biol Chem , vol.286 , pp. 43437-43446
    • Rauen, T.1    Hedrich, C.M.2    Juang, Y.T.3
  • 60
    • 84899760423 scopus 로고    scopus 로고
    • CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance
    • Koga T, Hedrich CM, Mizui M, et al. CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance. J Clin Invest 2014; 124:2234-2245.
    • (2014) J Clin Invest , vol.124 , pp. 2234-2245
    • Koga, T.1    Hedrich, C.M.2    Mizui, M.3
  • 61
    • 84895800711 scopus 로고    scopus 로고
    • T follicular helper cells and regulatory B cells dynamics in systemic lupus erythematosus
    • Yang X, Yang J, Chu Y, et al. T follicular helper cells and regulatory B cells dynamics in systemic lupus erythematosus. PloS One 2014; 9:e88441.
    • (2014) PloS One , vol.9
    • Yang, X.1    Yang, J.2    Chu, Y.3
  • 62
    • 84876513517 scopus 로고    scopus 로고
    • T follicular helper cells mediate expansion of regulatory B cells via IL-21 in Lupus-prone MRL/lpr mice
    • Yang X, Yang J, Chu Y, et al. T follicular helper cells mediate expansion of regulatory B cells via IL-21 in Lupus-prone MRL/lpr mice. PloS One 2013; 8:e62855.
    • (2013) PloS One , vol.8
    • Yang, X.1    Yang, J.2    Chu, Y.3
  • 63
    • 74849138095 scopus 로고    scopus 로고
    • Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    • Simpson N, Gatenby PA, Wilson A, et al. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum 2010; 62:234-244.
    • (2010) Arthritis Rheum , vol.62 , pp. 234-244
    • Simpson, N.1    Gatenby, P.A.2    Wilson, A.3
  • 64
    • 84897508575 scopus 로고    scopus 로고
    • Pathogenic Th2-type follicular helper T cells contribute to the development of lupus in Fas-deficient mice
    • Futatsugi-Yumikura S, Matsushita K, Fukuoka A, et al. Pathogenic Th2-type follicular helper T cells contribute to the development of lupus in Fas-deficient mice. Int Immunol 2014; 26:221-231.
    • (2014) Int Immunol , vol.26 , pp. 221-231
    • Futatsugi-Yumikura, S.1    Matsushita, K.2    Fukuoka, A.3
  • 65
    • 79953160964 scopus 로고    scopus 로고
    • Follicular helper T cells in systemic lupus erythematosus: A potential therapeutic target
    • Dong W, Zhu P, Wang Y, Wang Z. Follicular helper T cells in systemic lupus erythematosus: a potential therapeutic target. Autoimmun Rev 2011; 10:299-304.
    • (2011) Autoimmun Rev , vol.10 , pp. 299-304
    • Dong, W.1    Zhu, P.2    Wang, Y.3    Wang, Z.4
  • 67
    • 35348876040 scopus 로고    scopus 로고
    • IPEX, FOXP3 and regulatory T-cells: A model for autoimmunity
    • Ochs HD, Gambineri E, Torgerson TR. IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity. Immunol Res 2007; 38:112-121.
    • (2007) Immunol Res , vol.38 , pp. 112-121
    • Ochs, H.D.1    Gambineri, E.2    Torgerson, T.R.3
  • 68
    • 45849145442 scopus 로고    scopus 로고
    • Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE)
    • Bonelli M, Savitskaya A, von Dalwigk K, et al. Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE). Int Immunol 2008; 20:861-868.
    • (2008) Int Immunol , vol.20 , pp. 861-868
    • Bonelli, M.1    Savitskaya, A.2    Von Dalwigk, K.3
  • 69
    • 43249122144 scopus 로고    scopus 로고
    • Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance
    • Vargas-Rojas MI, Crispin JC, Richaud-Patin Y, Alcocer-Varela J. Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance. Lupus 2008; 17:289-294.
    • (2008) Lupus , vol.17 , pp. 289-294
    • Vargas-Rojas, M.I.1    Crispin, J.C.2    Richaud-Patin, Y.3    Alcocer-Varela, J.4
  • 70
    • 68149158968 scopus 로고    scopus 로고
    • Cutting edge: Regulatory T cells directly suppress B cells in systemic lupus erythematosus
    • Iikuni N, Lourenco EV, Hahn BH, La Cava A. Cutting edge: regulatory T cells directly suppress B cells in systemic lupus erythematosus. J Immunol 2009; 183:1518-1522.
    • (2009) J Immunol , vol.183 , pp. 1518-1522
    • Iikuni, N.1    Lourenco, E.V.2    Hahn, B.H.3    La Cava, A.4
  • 71
    • 76349096767 scopus 로고    scopus 로고
    • Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of lupus
    • Zhang L, Bertucci AM, Ramsey-Goldman R, et al. Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of lupus. J Immunol 2009; 183:6346-6358.
    • (2009) J Immunol , vol.183 , pp. 6346-6358
    • Zhang, L.1    Bertucci, A.M.2    Ramsey-Goldman, R.3
  • 72
    • 67849099131 scopus 로고    scopus 로고
    • Recent insights into the genetic basis of systemic lupus erythematosus
    • Moser KL, Kelly JA, Lessard CJ, Harley JB. Recent insights into the genetic basis of systemic lupus erythematosus. Genes Immun 2009; 10:373-379.
    • (2009) Genes Immun , vol.10 , pp. 373-379
    • Moser, K.L.1    Kelly, J.A.2    Lessard, C.J.3    Harley, J.B.4
  • 74
    • 84881301739 scopus 로고    scopus 로고
    • Genetics and epigenetics of systemic lupus erythematosus
    • Costa-Reis P, Sullivan KE. Genetics and epigenetics of systemic lupus erythematosus. Curr Rheumatol Rep 2013; 15:369.
    • (2013) Curr Rheumatol Rep , vol.15 , pp. 369
    • Costa-Reis, P.1    Sullivan, K.E.2
  • 75
    • 33744936286 scopus 로고    scopus 로고
    • The epigenetic face of systemic lupus erythematosus
    • Ballestar E, Esteller M, Richardson BC. The epigenetic face of systemic lupus erythematosus. J Immunol 2006; 176:7143-7147.
    • (2006) J Immunol , vol.176 , pp. 7143-7147
    • Ballestar, E.1    Esteller, M.2    Richardson, B.C.3
  • 76
    • 0033634930 scopus 로고    scopus 로고
    • DNA methylation in the regulation of T cell LFA-1 expression
    • Kaplan MJ, Deng C, Yang J, Richardson BC. DNA methylation in the regulation of T cell LFA-1 expression. Immunol Invest 2000; 29:411-425.
    • (2000) Immunol Invest , vol.29 , pp. 411-425
    • Kaplan, M.J.1    Deng, C.2    Yang, J.3    Richardson, B.C.4
  • 77
    • 84878361920 scopus 로고    scopus 로고
    • Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferonregulated genes in naive CD4+ T cells from lupus patients
    • Coit P, Jeffries M, Altorok N, et al. Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferonregulated genes in naive CD4+ T cells from lupus patients. J Autoimmun 2013; 43:78-84.
    • (2013) J Autoimmun , vol.43 , pp. 78-84
    • Coit, P.1    Jeffries, M.2    Altorok, N.3
  • 78
    • 84884634092 scopus 로고    scopus 로고
    • Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations
    • Absher DM, Li X, Waite LL, et al. Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations. PLoS Genet 2013; 9:e1003678.
    • (2013) PLoS Genet , vol.9
    • Absher, D.M.1    Li, X.2    Waite, L.L.3
  • 79
    • 79955048011 scopus 로고    scopus 로고
    • Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus
    • Sunahori K, Juang YT, Kyttaris VC, Tsokos GC. Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus. J Immunol 2011; 186:4508-4517.
    • (2011) J Immunol , vol.186 , pp. 4508-4517
    • Sunahori, K.1    Juang, Y.T.2    Kyttaris, V.C.3    Tsokos, G.C.4
  • 80
    • 84875961571 scopus 로고    scopus 로고
    • Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus
    • Zhang Y, Zhao M, Sawalha AH, et al. Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus. J Autoimmun 2013; 41:92-99.
    • (2013) J Autoimmun , vol.41 , pp. 92-99
    • Zhang, Y.1    Zhao, M.2    Sawalha, A.H.3
  • 81
    • 44349087706 scopus 로고    scopus 로고
    • Abnormal histone modification patterns in lupus CD4+ T cells
    • Hu N, Qiu X, Luo Y, et al. Abnormal histone modification patterns in lupus CD4+ T cells. J Rheumatol 2008; 35:804-810.
    • (2008) J Rheumatol , vol.35 , pp. 804-810
    • Hu, N.1    Qiu, X.2    Luo, Y.3
  • 82
    • 0037330279 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse
    • Mishra N, Reilly CM, Brown DR, et al. Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. J Clin Invest 2003; 111:539-552.
    • (2003) J Clin Invest , vol.111 , pp. 539-552
    • Mishra, N.1    Reilly, C.M.2    Brown, D.R.3
  • 83
    • 84898417990 scopus 로고    scopus 로고
    • Epigenetic dysregulation in systemic lupus erythematosus
    • Liu A, La Cava A. Epigenetic dysregulation in systemic lupus erythematosus. Autoimmunity 2014; 47:215-219.
    • (2014) Autoimmunity , vol.47 , pp. 215-219
    • Liu, A.1    La Cava, A.2
  • 84
    • 84861535981 scopus 로고    scopus 로고
    • MiRNA in systemic lupus erythematosus
    • Amarilyo G, La Cava A. miRNA in systemic lupus erythematosus. Clin Immunol 2012; 144:26-31.
    • (2012) Clin Immunol , vol.144 , pp. 26-31
    • Amarilyo, G.1    La Cava, A.2
  • 85
    • 77953624215 scopus 로고    scopus 로고
    • MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1
    • Pan W, Zhu S, YuanM, et al. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol 2010; 184:6773-6781.
    • (2010) J Immunol , vol.184 , pp. 6773-6781
    • Pan, W.1    Zhu, S.2    Yuan, M.3
  • 86
    • 79959784552 scopus 로고    scopus 로고
    • Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: MiR-21 regulates aberrant T cell responses through regulation of PDCD4 expression
    • Stagakis E, Bertsias G, Verginis P, et al. Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression. Ann Rheum Dis 2011; 70:1496-1506.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1496-1506
    • Stagakis, E.1    Bertsias, G.2    Verginis, P.3
  • 87
    • 84896266559 scopus 로고    scopus 로고
    • Microarray technology for analysis of microRNA expression in renal biopsies of lupus nephritis patients
    • Sui W, Liu F, Chen J, et al. Microarray technology for analysis of microRNA expression in renal biopsies of lupus nephritis patients. Methods Mol Biol 2014; 1134:211-220.
    • (2014) Methods Mol Biol , vol.1134 , pp. 211-220
    • Sui, W.1    Liu, F.2    Chen, J.3
  • 88
    • 84905487796 scopus 로고    scopus 로고
    • A114: Methylprednisolone-induced inhibition of miR-155 expression increases SOCS1-driven suppression of cytokine signaling
    • Davis TE, Kis-Toth K, Tsokos GC. A114: methylprednisolone-induced inhibition of miR-155 expression increases SOCS1-driven suppression of cytokine signaling. Arthritis Rheumatol 2014; 66 (Suppl 11):S151.
    • (2014) Arthritis Rheumatol , vol.66 , Issue.SUPPL. 11
    • Davis, T.E.1    Kis-Toth, K.2    Tsokos, G.C.3


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