-
1
-
-
84887125401
-
CAMP responsive element modulator (CREM)α trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease
-
Hedrich, C. M., Rauen, T., Crispin, J. C., Koga, T., Ioannidis, C., Zajdel, M., Kyttaris, V. C., and Tsokos, G. C. (2013) cAMP responsive element modulator (CREM)α trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease. J. Biol. Chem. 288, 31880-31887
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 31880-31887
-
-
Hedrich, C.M.1
Rauen, T.2
Crispin, J.C.3
Koga, T.4
Ioannidis, C.5
Zajdel, M.6
Kyttaris, V.C.7
Tsokos, G.C.8
-
2
-
-
0031132580
-
A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice
-
Hostert, A., Tolaini, M., Festenstein, R., McNeill, L., Malissen, B., Williams, O., Zamoyska, R., and Kioussis, D. (1997) A CD8 genomic fragment that directs subset-specific expression of CD8 in transgenic mice. J. Immunol. 158, 4270-4281
-
(1997)
J. Immunol.
, vol.158
, pp. 4270-4281
-
-
Hostert, A.1
Tolaini, M.2
Festenstein, R.3
McNeill, L.4
Malissen, B.5
Williams, O.6
Zamoyska, R.7
Kioussis, D.8
-
3
-
-
0031573227
-
Appropriate developmental expression of human CD8+ in transgenic mice
-
Kieffer, L. J., Yan, L., Hanke, J. H., and Kavathas, P. B. (1997) Appropriate developmental expression of human CD8+ in transgenic mice. J. Immunol. 159, 4907-4912
-
(1997)
J. Immunol.
, vol.159
, pp. 4907-4912
-
-
Kieffer, L.J.1
Yan, L.2
Hanke, J.H.3
Kavathas, P.B.4
-
4
-
-
33645107299
-
Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR
-
Bilic, I., Koesters, C., Unger, B., Sekimata, M., Hertweck, A., Maschek, R., Wilson, C. B., and Ellmeier, W. (2006) Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR. Nat. Immunol. 7, 392-400
-
(2006)
Nat. Immunol.
, vol.7
, pp. 392-400
-
-
Bilic, I.1
Koesters, C.2
Unger, B.3
Sekimata, M.4
Hertweck, A.5
Maschek, R.6
Wilson, C.B.7
Ellmeier, W.8
-
5
-
-
0036885036
-
Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation
-
Kioussis, D., and Ellmeier, W. (2002) Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation. Nat. Rev. Immunol. 2, 909-919
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 909-919
-
-
Kioussis, D.1
Ellmeier, W.2
-
6
-
-
0030670312
-
An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells
-
Ellmeier, W., Sunshine, M. J., Losos, K., Hatam, F., and Littman, D. R. (1997) An enhancer that directs lineage-specific expression of CD8 in positively selected thymocytes and mature T cells. Immunity 7, 537-547
-
(1997)
Immunity
, vol.7
, pp. 537-547
-
-
Ellmeier, W.1
Sunshine, M.J.2
Losos, K.3
Hatam, F.4
Littman, D.R.5
-
7
-
-
0032191963
-
Multiple developmental stage-specific enhancers regulateCD8expression in developing thymocytes and in thymus-independent T cells
-
Ellmeier, W., Sunshine, M. J., Losos, K., and Littman, D. R. (1998) Multiple developmental stage-specific enhancers regulateCD8expression in developing thymocytes and in thymus-independent T cells. Immunity 9, 485-496
-
(1998)
Immunity
, vol.9
, pp. 485-496
-
-
Ellmeier, W.1
Sunshine, M.J.2
Losos, K.3
Littman, D.R.4
-
8
-
-
0036285006
-
Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression
-
Ellmeier, W., Sunshine, M. J., Maschek, R., and Littman, D. R. (2002) Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity 16, 623-634
-
(2002)
Immunity
, vol.16
, pp. 623-634
-
-
Ellmeier, W.1
Sunshine, M.J.2
Maschek, R.3
Littman, D.R.4
-
9
-
-
0036286001
-
Variegated expression of CD8+ resulting from in situ deletion of regulatory sequences
-
Garefalaki, A., Coles, M., Hirschberg, S., Mavria, G., Norton, T., Hostert, A., and Kioussis, D. (2002) Variegated expression of CD8+ resulting from in situ deletion of regulatory sequences. Immunity 16, 635-647
-
(2002)
Immunity
, vol.16
, pp. 635-647
-
-
Garefalaki, A.1
Coles, M.2
Hirschberg, S.3
Mavria, G.4
Norton, T.5
Hostert, A.6
Kioussis, D.7
-
10
-
-
0030725991
-
A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice
-
Hostert, A., Tolaini, M., Roderick, K., Harker, N., Norton, T., and Kioussis, D. (1997) A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice. Immunity 7, 525-536
-
(1997)
Immunity
, vol.7
, pp. 525-536
-
-
Hostert, A.1
Tolaini, M.2
Roderick, K.3
Harker, N.4
Norton, T.5
Kioussis, D.6
-
11
-
-
0032192483
-
Hierarchical interactions of control elements determine CD8+ gene expression in subsets of thymocytes and peripheral T cells
-
Hostert, A., Garefalaki, A., Mavria, G., Tolaini, M., Roderick, K., Norton, T., Mee, P. J., Tybulewicz, V. L., Coles, M., and Kioussis, D. (1998) Hierarchical interactions of control elements determine CD8+ gene expression in subsets of thymocytes and peripheral T cells. Immunity 9, 497-508
-
(1998)
Immunity
, vol.9
, pp. 497-508
-
-
Hostert, A.1
Garefalaki, A.2
Mavria, G.3
Tolaini, M.4
Roderick, K.5
Norton, T.6
Mee, P.J.7
Tybulewicz, V.L.8
Coles, M.9
Kioussis, D.10
-
12
-
-
0029800546
-
Human CD8+ expression in NK cells but not cytotoxic T cells of transgenic mice
-
Kieffer, L. J., Bennett, J. A., Cunningham, A. C., Gladue, R. P., McNeish, J., Kavathas, P. B., and Hanke, J. H. (1996) Human CD8+ expression in NK cells but not cytotoxic T cells of transgenic mice. Int. Immunol. 8, 1617-1626
-
(1996)
Int. Immunol.
, vol.8
, pp. 1617-1626
-
-
Kieffer, L.J.1
Bennett, J.A.2
Cunningham, A.C.3
Gladue, R.P.4
McNeish, J.5
Kavathas, P.B.6
Hanke, J.H.7
-
13
-
-
0032169239
-
Distinct stage-specific cis-active transcriptional mechanisms control expression of T cell coreceptor CD8+ at double-and single-positive stages of thymic development
-
Zhang, X. L., Seong, R., Piracha, R., Larijani, M., Heeney, M., Parnes, J. R., and Chamberlain, J. W. (1998) Distinct stage-specific cis-active transcriptional mechanisms control expression of T cell coreceptor CD8+ at double-and single-positive stages of thymic development. J. Immunol. 161, 2254-2266
-
(1998)
J. Immunol.
, vol.161
, pp. 2254-2266
-
-
Zhang, X.L.1
Seong, R.2
Piracha, R.3
Larijani, M.4
Heeney, M.5
Parnes, J.R.6
Chamberlain, J.W.7
-
14
-
-
0035801606
-
CD8 expression up to the double-positive CD3(low/intermediate) stage of thymic differentiation is sufficient for development of peripheral functional cytotoxic T lymphocytes
-
Zhang, X. L., Zhao, S., Borenstein, S. H., Liu, Y., Jayabalasingham, B., and Chamberlain, J. W. (2001) CD8 expression up to the double-positive CD3(low/intermediate) stage of thymic differentiation is sufficient for development of peripheral functional cytotoxic T lymphocytes. J. Exp. Med. 194, 685-693
-
(2001)
J. Exp. Med.
, vol.194
, pp. 685-693
-
-
Zhang, X.L.1
Zhao, S.2
Borenstein, S.H.3
Liu, Y.4
Jayabalasingham, B.5
Chamberlain, J.W.6
-
15
-
-
12444333478
-
Functional and molecular analysis of the double-positive stagespecific CD8 enhancer E8III during thymocyte development
-
Feik, N., Bilic, I., Tinhofer, J., Unger, B., Littman, D. R., and Ellmeier, W. (2005) Functional and molecular analysis of the double-positive stagespecific CD8 enhancer E8III during thymocyte development. J. Immunol. 174, 1513-1524
-
(2005)
J. Immunol.
, vol.174
, pp. 1513-1524
-
-
Feik, N.1
Bilic, I.2
Tinhofer, J.3
Unger, B.4
Littman, D.R.5
Ellmeier, W.6
-
16
-
-
84855961987
-
Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases
-
Hedrich, C. M., and Tsokos, G. C. (2011) Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases. Trends Mol. Med. 17, 714-724
-
(2011)
Trends Mol. Med.
, vol.17
, pp. 714-724
-
-
Hedrich, C.M.1
Tsokos, G.C.2
-
17
-
-
83355166950
-
CAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene. Implications in systemic lupus erythematosus
-
Hedrich, C. M., Rauen, T., and Tsokos, G. C. (2011) cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene. Implications in systemic lupus erythematosus. J. Biol. Chem. 286, 43429-43436
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 43429-43436
-
-
Hedrich, C.M.1
Rauen, T.2
Tsokos, G.C.3
-
18
-
-
84867351076
-
CAMPresponse element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus
-
Hedrich, C. M., Crispin, J. C., Rauen, T., Ioannidis, C., Apostolidis, S. A., Lo, M. S., Kyttaris, V. C., and Tsokos, G. C. (2012)cAMPresponse element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus. Proc. Natl. Acad. Sci. U.S.A. 109, 16606-16611
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 16606-16611
-
-
Hedrich, C.M.1
Crispin, J.C.2
Rauen, T.3
Ioannidis, C.4
Apostolidis, S.A.5
Lo, M.S.6
Kyttaris, V.C.7
Tsokos, G.C.8
-
19
-
-
83355166923
-
CAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus
-
Rauen, T., Hedrich, C. M., Juang, Y. T., Tenbrock, K., and Tsokos, G. C. (2011) cAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus. J. Biol. Chem. 286, 43437-43446
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 43437-43446
-
-
Rauen, T.1
Hedrich, C.M.2
Juang, Y.T.3
Tenbrock, K.4
Tsokos, G.C.5
-
20
-
-
16844376445
-
Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
-
Juang, Y. T., Wang, Y., Solomou, E. E., Li, Y., Mawrin, C., Tenbrock, K., Kyttaris, V. C., and Tsokos, G. C. (2005) Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV. J. Clin. Invest. 115, 996-1005
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 996-1005
-
-
Juang, Y.T.1
Wang, Y.2
Solomou, E.E.3
Li, Y.4
Mawrin, C.5
Tenbrock, K.6
Kyttaris, V.C.7
Tsokos, G.C.8
-
21
-
-
34249290027
-
A methylation rendezvous. Reader meets writers
-
Brenner, C., and Fuks, F. (2007) A methylation rendezvous. Reader meets writers. Dev. Cell. 12, 843-844
-
(2007)
Dev. Cell.
, vol.12
, pp. 843-844
-
-
Brenner, C.1
Fuks, F.2
-
22
-
-
84875846171
-
CAMP responsive element modulator. A critical regulator of cytokine production
-
Rauen, T., Hedrich, C. M., Tenbrock, K., and Tsokos, G. C. (2013) cAMP responsive element modulator. A critical regulator of cytokine production. Trends Mol. Med. 19, 262-269
-
(2013)
Trends Mol. Med.
, vol.19
, pp. 262-269
-
-
Rauen, T.1
Hedrich, C.M.2
Tenbrock, K.3
Tsokos, G.C.4
-
23
-
-
0035816682
-
Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3
-
Tachibana, M., Sugimoto, K., Fukushima, T., and Shinkai, Y. (2001) Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. J. Biol. Chem. 276, 25309-25317
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 25309-25317
-
-
Tachibana, M.1
Sugimoto, K.2
Fukushima, T.3
Shinkai, Y.4
-
24
-
-
15244342946
-
Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes
-
Sato, T., Ohno, S., Hayashi, T., Sato, C., Kohu, K., Satake, M., and Habu, S. (2005) Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes. Immunity 22, 317-328
-
(2005)
Immunity
, vol.22
, pp. 317-328
-
-
Sato, T.1
Ohno, S.2
Hayashi, T.3
Sato, C.4
Kohu, K.5
Satake, M.6
Habu, S.7
-
25
-
-
79958060651
-
Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development
-
Harker, N., Garefalaki, A., Menzel, U., Ktistaki, E., Naito, T., Georgopoulos, K., and Kioussis, D. (2011) Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development. J. Immunol. 186, 6368-6377
-
(2011)
J. Immunol.
, vol.186
, pp. 6368-6377
-
-
Harker, N.1
Garefalaki, A.2
Menzel, U.3
Ktistaki, E.4
Naito, T.5
Georgopoulos, K.6
Kioussis, D.7
-
26
-
-
18244365863
-
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival
-
Lee, P. P., Fitzpatrick, D. R., Beard, C., Jessup, H. K., Lehar, S., Makar, K. W., Pérez-Melgosa, M., Sweetser, M. T., Schlissel, M. S., Nguyen, S., Cherry, S. R., Tsai, J. H., Tucker, S. M., Weaver, W. M., Kelso, A., Jaenisch, R., and Wilson, C. B. (2001) A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15, 763-774
-
(2001)
Immunity
, vol.15
, pp. 763-774
-
-
Lee, P.P.1
Fitzpatrick, D.R.2
Beard, C.3
Jessup, H.K.4
Lehar, S.5
Makar, K.W.6
Pérez-Melgosa, M.7
Sweetser, M.T.8
Schlissel, M.S.9
Nguyen, S.10
Cherry, S.R.11
Tsai, J.H.12
Tucker, S.M.13
Weaver, W.M.14
Kelso, A.15
Jaenisch, R.16
Wilson, C.B.17
-
27
-
-
0027279683
-
CD2-CD4-CD8- lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2+CD4+CD8+ thymic precursor
-
Landolfi, M. M., Van Houten, N., Russell, J. Q., Scollay, R., Parnes, J. R., and Budd, R. C. (1993) CD2-CD4-CD8- lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2+CD4+CD8+ thymic precursor. J. Immunol. 151, 1086-1096
-
(1993)
J. Immunol.
, vol.151
, pp. 1086-1096
-
-
Landolfi, M.M.1
Van Houten, N.2
Russell, J.Q.3
Scollay, R.4
Parnes, J.R.5
Budd, R.C.6
-
28
-
-
0025186696
-
CD4-CD8- thymocytes that express the T cell receptor may have previously expressed CD8
-
Wu, L., Pearse, M., Egerton, M., Petrie, H., and Scollay, R. (1990) CD4-CD8- thymocytes that express the T cell receptor may have previously expressed CD8. Int. Immunol. 2, 51-56
-
(1990)
Int. Immunol.
, vol.2
, pp. 51-56
-
-
Wu, L.1
Pearse, M.2
Egerton, M.3
Petrie, H.4
Scollay, R.5
-
29
-
-
0029939490
-
Differential interactions of the CREB/ATF family of transcription factors with p300 and adenovirus E1A
-
Lee, J. S., Zhang, X., and Shi, Y. (1996) Differential interactions of the CREB/ATF family of transcription factors with p300 and adenovirus E1A. J. Biol. Chem. 271, 17666-17674
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 17666-17674
-
-
Lee, J.S.1
Zhang, X.2
Shi, Y.3
-
30
-
-
18744398397
-
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
-
Taniuchi, I., Osato, M., Egawa, T., Sunshine, M. J., Bae, S. C., Komori, T., Ito, Y., and Littman, D. R. (2002) Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111, 621-633
-
(2002)
Cell
, vol.111
, pp. 621-633
-
-
Taniuchi, I.1
Osato, M.2
Egawa, T.3
Sunshine, M.J.4
Bae, S.C.5
Komori, T.6
Ito, Y.7
Littman, D.R.8
-
31
-
-
81055130116
-
Cd8 enhancer E8I and Runx factors regulate CD8+ expression in activated CD8+ T cells
-
Hassan, H., Sakaguchi, S., Tenno, M., Kopf, A., Boucheron, N., Carpenter, A. C., Egawa, T., Taniuchi, I., and Ellmeier, W. (2011) Cd8 enhancer E8I and Runx factors regulate CD8+ expression in activated CD8+ T cells. Proc. Natl. Acad. Sci. U.S.A. 108, 18330-18335
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 18330-18335
-
-
Hassan, H.1
Sakaguchi, S.2
Tenno, M.3
Kopf, A.4
Boucheron, N.5
Carpenter, A.C.6
Egawa, T.7
Taniuchi, I.8
Ellmeier, W.9
|