A novel intronic cAMP Response Element Modulator (CREM) promoter is regulated by Activator Protein-1 (AP-1) and accounts for altered activation-induced CREM Expression in T Cells from patients with systemic lupus erythematosus

Journal of Biological Chemistry

Volumn 286, Issue 37, 2011, Pages 32366-32372

  Rauen, Thomas ^a,b   Benedyk, Konrad ^c   Juang, Yuang Taung ^a   Kerkhoff, Claus ^c   Kyttaris, Vasileios C ^a   Roth, Johannes ^c   Tsokos, George C ^a   Tenbrock, Klaus ^b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATOR PROTEIN-1; CAMP-RESPONSE ELEMENT MODULATORS; CHROMATIN IMMUNOPRECIPITATION; DNA BINDING STUDIES; FEEDBACK MECHANISMS; FUNCTIONAL RELEVANCE; HEALTHY CONTROLS; HEALTHY INDIVIDUALS; IONOMYCIN; PHORBOL 12 MYRISTATE 13 ACETATES; PROMOTER ACTIVITIES; PUTATIVE BINDING SITES; REPORTER ASSAY; SYSTEMIC LUPUS ERYTHEMATOSUS; T CELL ACTIVATION; T CELLS; TATA-BINDING PROTEINS; TRANSCRIPTIONAL ACTIVATORS; TRANSCRIPTIONAL MACHINERY; TRANSCRIPTIONAL REPRESSORS; UP-REGULATION;

BINDING SITES; CELLS; CHEMICAL ACTIVATION; FETAL MONITORING; GENES; MACHINERY; PHYSIOLOGY; PROTEINS; TRANSCRIPTION;

CYTOLOGY;

CD28 ANTIGEN; CD3 ANTIGEN; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN C FOS; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CELL LEVEL; CONTROLLED STUDY; CREM GENE; EXON; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; INTRON; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROMOTER REGION; REGULATOR GENE; STRUCTURE ACTIVITY RELATION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION; UPREGULATION;

ANTIGENS, CD28; ANTIGENS, CD3; CARCINOGENS; CYCLIC AMP RESPONSE ELEMENT MODULATOR; EXONS; HUMANS; IONOMYCIN; IONOPHORES; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; PROTO-ONCOGENE PROTEINS C-FOS; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1; UP-REGULATION;

EID: 80052731499     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.245811     Document Type: Article

References (33)

1. Tenbrock, K., and Tsokos, G. C. (2004) Int. Rev. Immunol. 23, 333-345
2. Halder, S. K., Fink, M., Waterman, M. R., and Rozman, D. (2002) Mol. Endocrinol. 16, 1853-1863
3. Fimia, G. M., Morlon, A., Macho, B., De Cesare, D., and Sassone-Corsi, P. (2001) Mol. Cell. Endocrinol. 179, 17-23
4. Delmas, V., Laoide, B. M., Masquilier, D., de Groot, R. P., Foulkes, N. S., and Sassone-Corsi, P. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 4226-4230
5. Foulkes, N. S., Duval, G., and Sassone-Corsi, P. (1996) Nature 381, 83-85
6. Sassone-Corsi, P. (1995) Annu. Rev. Cell Dev. Biol. 11, 355-377
7. Powell, J. D., Lerner, C. G., Ewoldt, G. R., and Schwartz, R. H. (1999) J. Immunol. 163, 6631-6639
8. Solomou, E. E., Juang, Y. T., Gourley, M. F., Kammer, G. M., and Tsokos, G. C. (2001) J. Immunol. 166, 4216-4222
9. Tenbrock, K., Juang, Y. T., Gourley, M. F., Nambiar, M. P., and Tsokos, G. C. (2002) J. Immunol. 169, 4147-4152
10. Juang, Y. T., Wang, Y., Solomou, E. E., Li, Y., Mawrin, C., Tenbrock, K., Kyttaris, V. C., and Tsokos, G. C. (2005) J. Clin. Invest. 115, 996-1005
11. Crispín, J. C., Liossis, S. N., Kis-Toth, K., Lieberman, L. A., Kyttaris, V. C., Juang, Y. T., and Tsokos, G. C. (2010) Trends Mol. Med. 16, 47-57
12. Tsokos, G. C., Wong, H. K., Enyedy, E. J., and Nambiar, M. P. (2000) Curr. Opin. Rheumatol. 12, 355-363
13. Kyttaris, V. C., Juang, Y. T., Tenbrock, K., Weinstein, A., and Tsokos, G. C. (2004) J. Immunol. 173, 3557-3563
14. Tenbrock, K., Kyttaris, V. C., Ahlmann, M., Ehrchen, J. M., Tolnay, M., Melkonyan, H., Mawrin, C., Roth, J., Sorg, C., Juang, Y. T., and Tsokos, G. C. (2005) J. Immunol. 175, 5975-5980
15. Ahlmann, M., Varga, G., Sturm, K., Lippe, R., Benedyk, K., Viemann, D., Scholzen, T., Ehrchen, J., Müller, F. U., Seidl, M., Matus, M., Tsokos, G. C., Roth, J., and Tenbrock, K. (2009) J. Immunol. 182, 4167-4174
16. Kyttaris, V. C., Wang, Y., Juang, Y. T., Weinstein, A., and Tsokos, G. C. (2006) Lupus 15, 840-844
17. Juang, Y. T., Rauen, T., Wang, Y., Ichinose, K., Benedyk, K., Tenbrock, K., and Tsokos, G. C. (2011) J. Biol. Chem. 286, 1795-1801
18. Hochberg, M. C. (1997) Arthritis Rheum. 40, 1725
19. Crispín, J. C., and Tsokos, G. C. (2009) Autoimmun. Rev. 8, 190-195
20. Ragheb, J.A., Deen, M., and Schwartz, R.H. (1999) J. Immunol. 163, 120-129
21. Boussif, O., Lezoualc'h, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B., and Behr, J. P. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 7297-7301
22. Fujimoto, T., Fujisawa, J., and Yoshida, M. (1994) J. Biochem. 115, 298-303
23. Jung, S. H., Woo, M. S., Kim, S. Y., Kim, W. K., Hyun, J. W., Kim, E. J., Kim, D. H., and Kim, H. S. (2006) Int. J. Cancer 118, 490-497
24. Grassl, C., Luckow, B., Schlöndorff, D., and Dendorfer, U. (1999) J. Am. Soc. Nephrol. 10, 1466-1477
25. Jain, J., Loh, C., and Rao, A. (1995) Curr. Opin. Immunol. 7, 333-342
26. Jain, J., McCaffrey, P. G., Miner, Z., Kerppola, T. K., Lambert, J. N., Verdine, G. L., Curran, T., and Rao, A. (1993) Nature 365, 352-355
27. Jain, J., Valge-Archer, V. E., and Rao, A. (1992) J. Immunol. 148, 1240-1250
28. Lacroix, I., Lipcey, C., Imbert, J., and Kahn-Perlès, B. (2002) J. Biol. Chem. 277, 9598-9605
29. Deleted in proof
30. Foulkes, N. S., Borrelli, E., and Sassone-Corsi, P. (1991) Cell 64, 739-749
31. Montminy, M. (1997) Annu. Rev. Biochem. 66, 807-822
32. Daniel, P. B., Rohrbach, L., and Habener, J. F. (2000) Endocrinology 141, 3923-3930
33. Bodor, J., Feigenbaum, L., Bodorova, J., Bare, C., Reitz, M. S., Jr., and Gress, R. E. (2001) J. Leukocyte Biol. 69, 1053-1059