Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 5, 2013, Pages 1845-1850

  Moulton, Vaishali R ^a   Grammatikos, Alexandros P ^a   Fitzgerald, Lisa M ^a   Tsokos, George C ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Autoimmunity; Interleukin 2; SFRS1; T lymphocyte

Indexed keywords

CD3 ANTIGEN; INTERLEUKIN 2; LUCIFERASE; MESSENGER RNA; SERINE ARGININE RICH PROTEIN; SERINE ARGININE SPLICING FACTOR 2 ALTERNATIVE SPLICING FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; EXPRESSION VECTOR; FEMALE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN STABILITY; SIGNAL TRANSDUCTION; SLEDAI; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ADULT; FEMALE; HUMANS; IMMUNOBLOTTING; INTERLEUKIN-2; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; NUCLEAR PROTEINS; RECEPTORS, ANTIGEN, T-CELL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSCRIPTIONAL ACTIVATION; YOUNG ADULT;

EID: 84873176790     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1214207110     Document Type: Article

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