메뉴 건너뛰기




Volumn 117, Issue 3, 2014, Pages 246-256

Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: Effect of obesity vs. REDD1 deficiency

Author keywords

Diet induced obesity; Fasted; Fed; Raptor; Rheb

Indexed keywords

CARRIER PROTEIN; DDIT4 PROTEIN, MOUSE; EIF4EBP1 PROTEIN, MOUSE; INSULIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PHOSPHOPROTEIN; RPS6KA1 PROTEIN, MOUSE; S6 KINASE; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR;

EID: 84905438710     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01350.2013     Document Type: Article
Times cited : (41)

References (84)
  • 1
    • 79957769607 scopus 로고    scopus 로고
    • Oxidative DNA damage and obesity in type 2 diabetes mellitus
    • Al-Aubaidy HA, Jelinek HF. Oxidative DNA damage and obesity in type 2 diabetes mellitus. Eur J Endocrinol 164:899-904, 2011.
    • (2011) Eur J Endocrinol , vol.164 , pp. 899-904
    • Al-Aubaidy, H.A.1    Jelinek, H.F.2
  • 2
    • 35848964571 scopus 로고    scopus 로고
    • The changing relationship of obesity and disability, 1988-2004
    • Alley DE, Chang VW. The changing relationship of obesity and disability, 1988-2004. JAMA 298:2020-2027, 2007.
    • (2007) JAMA , vol.298 , pp. 2020-2027
    • Alley, D.E.1    Chang, V.W.2
  • 5
    • 0036230645 scopus 로고    scopus 로고
    • Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 and S6K1 phosphorylation
    • Anthony JC, Reiter AK, Anthony TG, Crozier SJ, Lang CH, MacLean DA, Kimball SR, Jefferson LS. Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 and S6K1 phosphorylation. Diabetes 51:928-936, 2002.
    • (2002) Diabetes , vol.51 , pp. 928-936
    • Anthony, J.C.1    Reiter, A.K.2    Anthony, T.G.3    Crozier, S.J.4    Lang, C.H.5    MacLean, D.A.6    Kimball, S.R.7    Jefferson, L.S.8
  • 6
    • 0022619965 scopus 로고
    • Effect of exercise on protein turnover in muscles of lean and obese mice
    • Augert G, Monier S, Le Marchand-Brustel Y. Effect of exercise on protein turnover in muscles of lean and obese mice. Diabetologia 29:248-253, 1986.
    • (1986) Diabetologia , vol.29 , pp. 248-253
    • Augert, G.1    Monier, S.2    Le Marchand-Brustel, Y.3
  • 7
    • 0021881862 scopus 로고
    • Effect of work-induced hypertrophy on muscle glucose metabolism in lean and obese mice
    • Augert G, Van De Werve G, Le Marchand-Brustel Y. Effect of work-induced hypertrophy on muscle glucose metabolism in lean and obese mice. Diabetologia 28:295-301, 1985.
    • (1985) Diabetologia , vol.28 , pp. 295-301
    • Augert, G.1    Van De Werve, G.2    Le Marchand-Brustel, Y.3
  • 10
    • 0037025356 scopus 로고    scopus 로고
    • AMP-Activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
    • Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. AMP-Activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem 277:23977-23980, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 23977-23980
    • Bolster, D.R.1    Crozier, S.J.2    Kimball, S.R.3    Jefferson, L.S.4
  • 14
    • 79953140160 scopus 로고    scopus 로고
    • Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids
    • Dennis MD, Baum JI, Kimball SR, Jefferson LS. Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids. J Biol Chem 286:8287-8296, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 8287-8296
    • Dennis, M.D.1    Baum, J.I.2    Kimball, S.R.3    Jefferson, L.S.4
  • 15
    • 84884558569 scopus 로고    scopus 로고
    • Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1)
    • Dennis MD, McGhee NK, Jefferson LS, Kimball SR. Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1). Cell Signal 25:2709-2716, 2013.
    • (2013) Cell Signal , vol.25 , pp. 2709-2716
    • Dennis, M.D.1    McGhee, N.K.2    Jefferson, L.S.3    Kimball, S.R.4
  • 16
    • 38349056675 scopus 로고    scopus 로고
    • Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
    • De Young MP, Horak P, Sofer A, Sgroi D, Ellisen LW. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev 22:239-251, 2008.
    • (2008) Genes Dev , vol.22 , pp. 239-251
    • De Young, M.P.1    Horak, P.2    Sofer, A.3    Sgroi, D.4    Ellisen, L.W.5
  • 18
    • 78649814492 scopus 로고    scopus 로고
    • AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle
    • Drake JC, Alway SE, Hollander JM, Williamson DL. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. Am J Physiol Regul Integr Comp Physiol 299:R1546-R1554, 2010.
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.299
    • Drake, J.C.1    Alway, S.E.2    Hollander, J.M.3    Williamson, D.L.4
  • 19
    • 84891558438 scopus 로고    scopus 로고
    • 8-Weeks of α-GPA treatment reduces body mass while positively altering translation initiation in obese skeletal muscle
    • doi:10.4172/2165-7904.1000101
    • Drake JC, Benninger L, Williamson DL. 8-Weeks of α-GPA treatment reduces body mass while positively altering translation initiation in obese skeletal muscle. J Obes Weight Loss Ther 01/2011; doi:10.4172/2165-7904.1000101.
    • (2011) J Obes Weight Loss Ther , vol.1
    • Drake, J.C.1    Benninger, L.2    Williamson, D.L.3
  • 21
    • 0021066904 scopus 로고
    • Skeletal muscle growth in lean and obese Zucker rats
    • Durschlag RP, Layman DK. Skeletal muscle growth in lean and obese Zucker rats. Growth 47:282-291, 1983.
    • (1983) Growth , vol.47 , pp. 282-291
    • Durschlag, R.P.1    Layman, D.K.2
  • 25
    • 0142126900 scopus 로고    scopus 로고
    • Impaired skeletal muscle perfusion in obese Zucker rats
    • Frisbee JC. Impaired skeletal muscle perfusion in obese Zucker rats. Am J Physiol Regul Integr Comp Physiol 285:R1124-R1134, 2003.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285
    • Frisbee, J.C.1
  • 26
    • 72449201711 scopus 로고    scopus 로고
    • Regulation of REDD1 by insulin-like growth factor-I in skeletal muscle and myotubes
    • Frost RA, Huber D, Pruznak A, Lang CH. Regulation of REDD1 by insulin-like growth factor-I in skeletal muscle and myotubes. J Cell Biochem 108:1192-1202, 2009.
    • (2009) J Cell Biochem , vol.108 , pp. 1192-1202
    • Frost, R.A.1    Huber, D.2    Pruznak, A.3    Lang, C.H.4
  • 29
    • 27744569843 scopus 로고    scopus 로고
    • MTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
    • Holz MK, Ballif BA, Gygi SP, Blenis J. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 123:569-580, 2005.
    • (2005) Cell , vol.123 , pp. 569-580
    • Holz, M.K.1    Ballif, B.A.2    Gygi, S.P.3    Blenis, J.4
  • 30
    • 0024601787 scopus 로고
    • Transcriptional regulation of decreased protein synthesis during skeletal muscle unloading
    • Howard G, Steffen JM, Geoghegan TE. Transcriptional regulation of decreased protein synthesis during skeletal muscle unloading. J Appl Physiol 66:1093-1098, 1989.
    • (1989) J Appl Physiol , vol.66 , pp. 1093-1098
    • Howard, G.1    Steffen, J.M.2    Geoghegan, T.E.3
  • 31
    • 84856166319 scopus 로고    scopus 로고
    • Altered REDD1, myostatin, and Akt/mTOR/FoxO/MAPK signaling in streptozotocininduced diabetic muscle atrophy
    • Hulmi JJ, Silvennoinen M, Lehti M, Kivela R, Kainulainen H. Altered REDD1, myostatin, and Akt/mTOR/FoxO/MAPK signaling in streptozotocininduced diabetic muscle atrophy. Am J Physiol Endocrinol Metab 302:E307-E315, 2012.
    • (2012) Am J Physiol Endocrinol Metab , vol.302
    • Hulmi, J.J.1    Silvennoinen, M.2    Lehti, M.3    Kivela, R.4    Kainulainen, H.5
  • 32
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki K, Li Y, Xu T, Guan KL. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17:1829-1834, 2003.
    • (2003) Genes Dev , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 33
    • 84872369332 scopus 로고    scopus 로고
    • The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb
    • Kelleher AR, Kimball SR, Dennis MD, Schilder RJ, Jefferson LS. The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb. Am J Physiol Endocrinol Metab 304:E229-E236, 2013.
    • (2013) Am J Physiol Endocrinol Metab , vol.304
    • Kelleher, A.R.1    Kimball, S.R.2    Dennis, M.D.3    Schilder, R.J.4    Jefferson, L.S.5
  • 34
    • 68949151833 scopus 로고    scopus 로고
    • Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse
    • Kemp JG, Blazev R, Stephenson DG, Stephenson GM. Morphological and biochemical alterations of skeletal muscles from the genetically obese (ob/ob) mouse. Int J Obes (Lond) 33:831-841, 2009.
    • (2009) Int J Obes (Lond) , vol.33 , pp. 831-841
    • Kemp, J.G.1    Blazev, R.2    Stephenson, D.G.3    Stephenson, G.M.4
  • 35
    • 14244256097 scopus 로고    scopus 로고
    • Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
    • Khamzina L, Veilleux A, Bergeron S, Marette A. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology 146:1473-1481, 2005.
    • (2005) Endocrinology , vol.146 , pp. 1473-1481
    • Khamzina, L.1    Veilleux, A.2    Bergeron, S.3    Marette, A.4
  • 37
    • 41249094257 scopus 로고    scopus 로고
    • Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis
    • Kimball SR, Do AN, Kutzler L, Cavener DR, Jefferson LS. Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. J Biol Chem 283:3465-3475, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 3465-3475
    • Kimball, S.R.1    Do, A.N.2    Kutzler, L.3    Cavener, D.R.4    Jefferson, L.S.5
  • 39
    • 0030901124 scopus 로고    scopus 로고
    • Insulin stimulates protein synthesis in skeletal muscle by enhancing the association of eIF-4E and eIF-4G
    • Kimball SR, Jurasinki CV, Lawrence JC Jr, Jefferson LS. Insulin stimulates protein synthesis in skeletal muscle by enhancing the association of eIF-4E and eIF-4G. Am J Physiol Cell Physiol 272:C754-C759, 1997.
    • (1997) Am J Physiol Cell Physiol , vol.272
    • Kimball, S.R.1    Jurasinki, C.V.2    Lawrence Jr., J.C.3    Jefferson, L.S.4
  • 41
    • 42549141544 scopus 로고    scopus 로고
    • Acute alcohol intoxication increases REDD1 in skeletal muscle
    • Lang CH, Frost RA, Vary TC. Acute alcohol intoxication increases REDD1 in skeletal muscle. Alcohol Clin Exp Res 32:796-805, 2008.
    • (2008) Alcohol Clin Exp Res , vol.32 , pp. 796-805
    • Lang, C.H.1    Frost, R.A.2    Vary, T.C.3
  • 43
    • 14844362769 scopus 로고    scopus 로고
    • Induction of a cell stress response gene RTP801 by DNA damaging agent methyl methanesulfonate through CCAAT/enhancer binding protein
    • Lin L, Qian Y, Shi X, Chen Y. Induction of a cell stress response gene RTP801 by DNA damaging agent methyl methanesulfonate through CCAAT/enhancer binding protein. Biochemistry 44:3909-3914, 2005.
    • (2005) Biochemistry , vol.44 , pp. 3909-3914
    • Lin, L.1    Qian, Y.2    Shi, X.3    Chen, Y.4
  • 44
    • 41949101770 scopus 로고    scopus 로고
    • SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs
    • Ma XM, Yoon SO, Richardson CJ, Julich K, Blenis J. SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell 133:303-313, 2008.
    • (2008) Cell , vol.133 , pp. 303-313
    • Ma, X.M.1    Yoon, S.O.2    Richardson, C.J.3    Julich, K.4    Blenis, J.5
  • 46
    • 65349086122 scopus 로고    scopus 로고
    • Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1
    • McGhee NK, Jefferson LS, Kimball SR. Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1. J Nutr 139:828-834, 2009.
    • (2009) J Nutr , vol.139 , pp. 828-834
    • McGhee, N.K.1    Jefferson, L.S.2    Kimball, S.R.3
  • 47
    • 80051785107 scopus 로고    scopus 로고
    • BMI and the risk of renal cell carcinoma
    • McGuire BB, Fitzpatrick JM. BMI and the risk of renal cell carcinoma. Curr Opin Urol 21:356-361, 2011.
    • (2011) Curr Opin Urol , vol.21 , pp. 356-361
    • McGuire, B.B.1    Fitzpatrick, J.M.2
  • 48
    • 0002523042 scopus 로고    scopus 로고
    • The pathway and mechanism of eukaryotic protein synthesis
    • edited by Hershey JWB, Mathews MB, Sonenberg N. Cold Spring Harbor: Cold Spring Harbor Laboratory Press
    • Merrick WC, Hershey J W B. The pathway and mechanism of eukaryotic protein synthesis. In: Translational Control, edited by Hershey JWB, Mathews MB, Sonenberg N. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 1996, p. 31-69.
    • (1996) Translational Control , pp. 31-69
    • Merrick, W.C.1    Hershey, J.W.B.2
  • 49
    • 57349116906 scopus 로고    scopus 로고
    • Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles of ob/ob mice
    • Miller AM, Brestoff JR, Phelps CB, Berk EZ, Reynolds TH. Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles of ob/ob mice. Am J Physiol Regul Integr Comp Physiol 295:R1431-R1438, 2008.
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.295
    • Miller, A.M.1    Brestoff, J.R.2    Phelps, C.B.3    Berk, E.Z.4    Reynolds, T.H.5
  • 50
    • 52649130278 scopus 로고    scopus 로고
    • Lower growth hormone and higher cortisol are associated with greater visceral adiposity, intramyocellular lipids, and insulin resistance in overweight girls
    • Misra M, Bredella MA, Tsai P, Mendes N, Miller KK, Klibanski A. Lower growth hormone and higher cortisol are associated with greater visceral adiposity, intramyocellular lipids, and insulin resistance in overweight girls. Am J Physiol Endocrinol Metab 295:E385-E392, 2008.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Misra, M.1    Bredella, M.A.2    Tsai, P.3    Mendes, N.4    Miller, K.K.5    Klibanski, A.6
  • 52
    • 79951958957 scopus 로고    scopus 로고
    • Rapid induction of REDD1 expression by endurance exercise in rat skeletal muscle
    • Murakami T, Hasegawa K, Yoshinaga M. Rapid induction of REDD1 expression by endurance exercise in rat skeletal muscle. Biochem Biophys Res Commun 405:615-619, 2011.
    • (2011) Biochem Biophys Res Commun , vol.405 , pp. 615-619
    • Murakami, T.1    Hasegawa, K.2    Yoshinaga, M.3
  • 55
    • 84862302508 scopus 로고    scopus 로고
    • Hyattsville, MD: National Center for Health Statistics. Centers for Disease Control and Prevention's CDC and National Center for Health Statistics NCHS. NCHS data brief
    • Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of Obesity in the United States, 2009-2010. Hyattsville, MD: National Center for Health Statistics. Centers for Disease Control and Prevention's (CDC) and National Center for Health Statistics (NCHS). NCHS data brief, no 82, 2012.
    • (2012) Prevalence of Obesity in the United States, 2009-2010 , Issue.82
    • Ogden, C.L.1    Carroll, M.D.2    Kit, B.K.3    Flegal, K.M.4
  • 57
    • 55949101805 scopus 로고    scopus 로고
    • Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading
    • Peterson JM, Bryner RW, Alway SE. Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading. Am J Physiol Cell Physiol 295:C521-C528, 2008.
    • (2008) Am J Physiol Cell Physiol , vol.295
    • Peterson, J.M.1    Bryner, R.W.2    Alway, S.E.3
  • 58
    • 46049119027 scopus 로고    scopus 로고
    • Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response
    • Protiva P, Hopkins ME, Baggett S, Yang H, Lipkin M, Holt PR, Kennelly EJ, Bernard WI. Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response. Int J Cancer 123:687-694, 2008.
    • (2008) Int J Cancer , vol.123 , pp. 687-694
    • Protiva, P.1    Hopkins, M.E.2    Baggett, S.3    Yang, H.4    Lipkin, M.5    Holt, P.R.6    Kennelly, E.J.7    Bernard, W.I.8
  • 62
    • 70349323414 scopus 로고    scopus 로고
    • Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5=-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside
    • Rivas DA, Yaspelkis BB 3rd, Hawley JA, Lessard SJ. Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5=-Aminoimidazole-4- carboxamide-1-beta-D-ribofuranoside. J Endocrinol 202:441-451, 2009.
    • (2009) J Endocrinol , vol.202 , pp. 441-451
    • Rivas, D.A.1    Yaspelkis III, B.B.2    Hawley, J.A.3    Lessard, S.J.4
  • 65
    • 84858446718 scopus 로고    scopus 로고
    • Regulation of cytoplasmic mRNA decay
    • Schoenberg DR, Maquat LE. Regulation of cytoplasmic mRNA decay. Nat Rev Genet 13:246-259, 2012.
    • (2012) Nat Rev Genet , vol.13 , pp. 246-259
    • Schoenberg, D.R.1    Maquat, L.E.2
  • 66
    • 84857914471 scopus 로고    scopus 로고
    • Rheb is a critical regulator of autophagy during myocardial ischemia: Pathophysiological implications in obesity and metabolic syndrome
    • Sciarretta S, Zhai P, Shao D, Maejima Y, Robbins J, Volpe M, Condorelli G, Sadoshima J. Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation 125:1134-1146, 2012.
    • (2012) Circulation , vol.125 , pp. 1134-1146
    • Sciarretta, S.1    Zhai, P.2    Shao, D.3    Maejima, Y.4    Robbins, J.5    Volpe, M.6    Condorelli, G.7    Sadoshima, J.8
  • 67
    • 0021752372 scopus 로고
    • Muscle protein turnover in the perfused hindquarters of lean and genetically obese-diabetic (db/db) mice
    • Shargill NS, Ohshima K, Bray GA, Chan TM. Muscle protein turnover in the perfused hindquarters of lean and genetically obese-diabetic (db/db) mice. Diabetes 33:1160-1164, 1984.
    • (1984) Diabetes , vol.33 , pp. 1160-1164
    • Shargill, N.S.1    Ohshima, K.2    Bray, G.A.3    Chan, T.M.4
  • 70
    • 71249106254 scopus 로고    scopus 로고
    • Chronic high fat feeding attenuates load-induced hypertrophy in mice
    • Sitnick M, Bodine SC, Rutledge JC. Chronic high fat feeding attenuates load-induced hypertrophy in mice. J Physiol 587:5753-5765, 2009.
    • (2009) J Physiol , vol.587 , pp. 5753-5765
    • Sitnick, M.1    Bodine, S.C.2    Rutledge, J.C.3
  • 71
    • 21744459535 scopus 로고    scopus 로고
    • Regulation of mTOR and cell growth in response to energy stress by REDD1
    • Sofer A, Lei K, Johannessen CM, Ellisen LW. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol 25:5834-5845, 2005.
    • (2005) Mol Cell Biol , vol.25 , pp. 5834-5845
    • Sofer, A.1    Lei, K.2    Johannessen, C.M.3    Ellisen, L.W.4
  • 72
    • 77956525248 scopus 로고    scopus 로고
    • Sarcopenia exacerbates obesity-Associated insulin resistance and dysglycemia: Findings from the National Health and Nutrition Examination Survey III
    • Srikanthan P, Hevener AL, Karlamangla AS. Sarcopenia exacerbates obesity-Associated insulin resistance and dysglycemia: findings from the National Health and Nutrition Examination Survey III. PLos One 5:e10805, 2010.
    • (2010) PLos One , vol.5
    • Srikanthan, P.1    Hevener, A.L.2    Karlamangla, A.S.3
  • 73
    • 80052520508 scopus 로고    scopus 로고
    • Relative muscle mass is inversely associated with insulin resistance and prediabetes. Findings from the third National Health and Nutrition Examination Survey
    • Srikanthan P, Karlamangla AS. Relative muscle mass is inversely associated with insulin resistance and prediabetes. Findings from the third National Health and Nutrition Examination Survey. J Clin Endocrinol Metab 96:2898-2903, 2011.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 2898-2903
    • Srikanthan, P.1    Karlamangla, A.S.2
  • 74
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-Activating protein complex toward Rheb
    • Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-Activating protein complex toward Rheb. Curr Biol 13:1259-1268, 2003.
    • (2003) Curr Biol , vol.13 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 75
    • 14244252683 scopus 로고    scopus 로고
    • Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes
    • Tremblay F, Gagnon A, Veilleux A, Sorisky A, Marette A. Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes. Endocrinology 146:1328-1337, 2005.
    • (2005) Endocrinology , vol.146 , pp. 1328-1337
    • Tremblay, F.1    Gagnon, A.2    Veilleux, A.3    Sorisky, A.4    Marette, A.5
  • 78
    • 33846007729 scopus 로고    scopus 로고
    • Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1
    • Wang H, Kubica N, Ellisen LW, Jefferson LS, Kimball SR. Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1. J Biol Chem 281:39128-39134, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 39128-39134
    • Wang, H.1    Kubica, N.2    Ellisen, L.W.3    Jefferson, L.S.4    Kimball, S.R.5
  • 79
    • 0038373385 scopus 로고    scopus 로고
    • Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals
    • Wang Z, Malone MH, Thomenius MJ, Zhong F, Xu F, Distelhorst CW. Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals. J Biol Chem 278:27053-27058, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 27053-27058
    • Wang, Z.1    Malone, M.H.2    Thomenius, M.J.3    Zhong, F.4    Xu, F.5    Distelhorst, C.W.6
  • 80
    • 84899922338 scopus 로고    scopus 로고
    • Treadmill exercise training modulates hepatic cholesterol metabolism and circulating PCSK9 concentration in high-fat-fed mice
    • Wen S, Jadhav KS, Williamson DL, Rideout TC. Treadmill exercise training modulates hepatic cholesterol metabolism and circulating PCSK9 concentration in high-fat-fed mice. J Lipids 2013:908048, 2013.
    • (2013) J Lipids , vol.2013 , pp. 908048
    • Wen, S.1    Jadhav, K.S.2    Williamson, D.L.3    Rideout, T.C.4
  • 81
    • 33745836687 scopus 로고    scopus 로고
    • Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR
    • Williamson DL, Bolster DR, Kimball SR, Jefferson LS. Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR. Am J Physiol Endocrinol Metab 291:E80-E89, 2006.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Williamson, D.L.1    Bolster, D.R.2    Kimball, S.R.3    Jefferson, L.S.4
  • 82
    • 68049100075 scopus 로고    scopus 로고
    • AMPK inhibits myoblast differentiation through a PGC-1alpha-dependent mechanism
    • Williamson DL, Butler DC, Alway SE. AMPK inhibits myoblast differentiation through a PGC-1alpha-dependent mechanism. Am J Physiol Endocrinol Metab 297:E304-E314, 2009.
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Williamson, D.L.1    Butler, D.C.2    Alway, S.E.3
  • 83
    • 33745024082 scopus 로고    scopus 로고
    • Exercise-induced alterations in extracellular signal-regulated kinases 1/2 and mammalian target of rapamycin (mTOR) to regulatory mechanisms of mRNA translation in mouse muscle
    • Williamson DL, Kubica N, Kimball SR, Jefferson LS. Exercise-induced alterations in extracellular signal-regulated kinases 1/2 and mammalian target of rapamycin (mTOR) to regulatory mechanisms of mRNA translation in mouse muscle. J Physiol 573:497-510, 2006.
    • (2006) J Physiol , vol.573 , pp. 497-510
    • Williamson, D.L.1    Kubica, N.2    Kimball, S.R.3    Jefferson, L.S.4
  • 84
    • 84878101513 scopus 로고    scopus 로고
    • Influence of glucocorticoids and growth hormone on insulin sensitivity in humans
    • Yuen KC, Chong LE, Riddle MC. Influence of glucocorticoids and growth hormone on insulin sensitivity in humans. Diabet Med 30:651-663, 2013. Diseases
    • (2013) Diabet Med , vol.30 , pp. 651-663
    • Yuen, K.C.1    Chong, L.E.2    Riddle, M.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.