The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb

American Journal of Physiology - Endocrinology and Metabolism

Volumn 304, Issue 2, 2013, Pages

  Kelleher, Andrew R ^a   Kimball, Scot R ^a   Dennis, Michael D ^a   Schilder, Rudolf J ^a   Jefferson, Leonard S ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

4E binding protein 1; 70 kilodalton ribosomal protein S6 kinase 1; Anabolic resistance; Casting; Mechanistic target of rapamycin complex 1; Puromycin; Regulated in development and DNA damage responses 1 2

Indexed keywords

LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; MUSCLE PROTEIN; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; REPRESSOR PROTEIN; REPRESSOR PROTEIN REDD1; REPRESSOR PROTEIN REDD2; S6 KINASE; S6 KINASE 1; SODIUM CHLORIDE; THREONINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DNA DAMAGE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEEDING; GENE EXPRESSION; GENE INDUCTION; HINDLIMB; IMMOBILIZATION; MALE; MUSCLE ATROPHY; MUSCLE MASS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SOLEUS MUSCLE;

ANIMALS; ENZYME ACTIVATION; HINDLIMB SUSPENSION; LEUCINE; MALE; MUSCLE, SKELETAL; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REPRESSOR PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84872369332     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00409.2012     Document Type: Article

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