Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response

International Journal of Cancer

Volumn 123, Issue 3, 2008, Pages 687-694

  Protiva, Petr ^a,b,c   Hopkins, Michael E ^b   Baggett, Scott ^d   Yang, Hui ^d   Lipkin, Martin ^b   Holt, Peter R ^b   Kennelly, Edward J ^d   Bernard, Weinstein I ^c  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Cell cycle arrest; Endoplasmic reticulum stress; Garcinia xanthochymus; Unfolded protein

Indexed keywords

BENZOPHENONE DERIVATIVE; CASPASE; CASPASE 3; CASPASE 7; GUTTIFERONE E; GUTTIFERONE H; ISOPRENE; XANTHOCHYMOL;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ATF4 GENE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL STRESS; CELL SURVIVAL; CHOP GENE; COLON CANCER; CONTROLLED STUDY; DDIT3 GENE; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; FLOW CYTOMETRY; GARCINIA; GARCINIA XANTHOCHYMUS; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; MEMBRANE POTENTIAL; MICROARRAY ANALYSIS; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; REDD1 GENE; UPREGULATION; XBP1 GENE;

ACTIVATING TRANSCRIPTION FACTOR 4; APOPTOSIS; BENZOPHENONES; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; GARCINIA; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HT29 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LINEAR MODELS; MITOCHONDRIAL MEMBRANES; NUCLEAR PROTEINS; PRENYLATION; PROTEIN KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 46049119027     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23515     Document Type: Article

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