Acute alcohol intoxication increases REDD1 in skeletal muscle

Alcoholism: Clinical and Experimental Research

Volumn 32, Issue 5, 2008, Pages 796-805

  Lang, Charles H ^a   Frost, Robert A ^a   Vary, Thomas C ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Ethanol; Mammalian Target of Rapamycin; Protein Synthesis; Translation Initiation

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL; DEXAMETHASONE SODIUM PHOSPHATE; GLUCOCORTICOID; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MIFEPRISTONE; MUSCLE PROTEIN; PROTEIN REDD1; REGULATOR PROTEIN; TERT BUTYL ALCOHOL; TUBEROUS SCLEROSIS 1; TUBEROUS SCLEROSIS 2;

ACUTE DISEASE; ALCOHOL CONSUMPTION; ALCOHOL INTOXICATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG MEGADOSE; ENZYME ACTIVITY; FAST MUSCLE; FEMALE; GASTROCNEMIUS MUSCLE; HEART MUSCLE; HINDLIMB; IMMUNOBLOTTING; MALE; MOUSE; MUSCLE CELL; NONHUMAN; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; RIBONUCLEASE PROTECTION ASSAY; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SOLEUS MUSCLE; WESTERN BLOTTING;

ALCOHOL DRINKING; ALCOHOLIC INTOXICATION; ANIMALS; CARRIER PROTEINS; CELL LINE; DNA-BINDING PROTEINS; FEMALE; MALE; MICE; MUSCLE FIBERS, FAST-TWITCH; MUSCLE, SKELETAL; MYOBLASTS, SKELETAL; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASES; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; REPRESSOR PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

MAMMALIA; RATTUS;

EID: 42549141544     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2008.00637.x     Document Type: Article

References (44)

1. Avruch J, Hara K, Lin Y, Liu M, Long X, Ortiz-Vega S, Yonezawa K (2006) Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene 25 : 6361 6372.
2. Baker RC, Sorensen SM, Deitrich RA (1982) The in vivo metabolism of tertiary butanol by adult rats. Alcohol Clin Exp Res 6 : 247 251.
3. Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG Jr. (2004) Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 18 : 2893 2904.
4. Corradetti MN, Inoki K, Guan KL (2005) The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem 280 : 9769 9772.
5. Ellisen LW (2005) Growth control under stress: mTOR regulation through the REDD1-TSC pathway. Cell Cycle 4 : 1500 1502.
6. Ellisen LW, Ramsayer KD, Johannessen CM, Yang A, Beppu H, Minda K, Oliner JD, McKeon F, Haber DA (2002) REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell 10 : 995 1005.
7. Fan J, Wojnar MM, Theodorakis M, Lang CH (1996) Regulation of insulin-like growth factor (IGF)-I mRNA and peptide and IGF-binding proteins by interleukin-1. Am J Physiol 270 : R621 R629.
8. Giegerich R, Meyer F, Schleiermacher C (1996) GeneFisher - software support for the detection of postulated genes. Proc Int Conf Intell Syst Mol Biol 4 : 68 77.
9. Hong-Brown LQ, Brown CR, Huber DS, Lang CH (2006) Alcohol and indinavir adversely affect protein synthesis and phosphorylation of MAPK and mTOR signaling pathways in C2C12 myocytes. Alcohol Clin Exp Res 30 : 1297 1307.
10. Hong-Brown LQ, Brown CR, Huber DS, Lang CH (2007) Alcohol regulates eukaryotic elongation factor 2 phosphorylation via an AMP-activated protein kinase-dependent mechanism in C2C12 skeletal myocytes. J Biol Chem 282 : 3702 3712.
11. Jin HO, An S, Lee HC, Woo SH, Seo SK, Choe TB, Yoo DH, Lee SB, Um HD, Lee SJ, Park MJ, Kim JI, Hong SI, Rhee CH, Park IC (2007) Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway. Cell Signal 19 : 1393 1403.
12. Jurasinski CV, Vary TC (1995) Insulin-like growth factor I accelerates protein synthesis in skeletal muscle during sepsis. Am J Physiol 269 : E977 E981.
13. Kumar V, Frost RA, Lang CH (2002) Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle. Am J Physiol Endocrinol Metab 283 : E917 E928.
14. Lang CH, Frost RA, Deshpande N, Kumar V, Vary TC, Jefferson LS, Kimball SR (2003) Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle. Am J Physiol Endocrinol Metab 285 : E1205 E1215.
15. Lang CH, Frost RA, Kumar V, Vary TC (2000) Impaired myocardial protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4F. Am J Physiol Endocrinol Metab 279 : E1029 E1038.
16. Lang CH, Frost RA, Summer AD, Vary TC (2005) Molecular mechanisms responsible for alcohol-induced myopathy in skeletal muscle and heart. Int J Biochem Cell Biol 37 : 2180 2195.
17. Lang CH, Frost RA, Svanberg E, Vary TC (2004a) IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats. Am J Physiol Endocrinol Metab 286 : E916 E926.
18. Lang CH, Frost RA, Vary TC (2007a) Regulation of muscle protein synthesis during sepsis and inflammation. Am J Physiol Endocrinol Metab 293 : E453 E459.
19. Lang CH, Frost RA, Vary TC (2007b) Skeletal muscle protein synthesis and degradation exhibit sexual dimorphism after chronic alcohol consumption but not acute intoxication. Am J Physiol Endocrinol Metab 292 : E1497 E1506.
20. Lang CH, Pruznak AM, Deshpande N, Palopoli MM, Frost RA, Vary TC (2004b) Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolism. Alcohol Clin Exp Res 28 : 1758 1767.
21. Lang CH, Silvis C, Nystrom G, Frost RA (2001) Regulation of myostatin by glucocorticoids after thermal injury. FASEB J 15 : 1807 1809.
22. Lang CH, Wu D, Frost RA, Jefferson LS, Kimball SR, Vary TC (1999) Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E. Am J Physiol 277 : E268 E276.
23. LeBlanc AE, Kalant H (1975) Ethanol-induced cross tolerance to several homologous alcohols in the rat. Toxicol Appl Pharmacol 32 : 123 128.
24. Li YH, Fan J, Lang CH (1997) Differential role of glucocorticoids in mediating endotoxin-induced changes in IGF-I and IGFBP-1. Am J Physiol 272 : R1990 R1997.
25. Li TK, Theorell H (1969) Human liver alcohol dehydrogenase: inhibition by pyrazole and pyrazole analogs. Acta Chem Scand 23 : 892 902.
26. Lin L, Stringfield TM, Shi X, Chen Y (2005) Arsenite induces a cell stress-response gene, RTP801, through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein. Biochem J 392 : 93 102.
27. Messingham KA, Faunce DE, Kovacs EJ (2002) Alcohol, injury, and cellular immunity. Alcohol 28 : 137 149.
28. Molina PE, Lang CH, Bagby GJ, Spitzer JJ (1991) Ethanol oxidation is not required to attenuate endotoxin-enhanced glucose metabolism. Am J Physiol 260 : R1058 R1065.
29. Patel VA, Pohorecky LA (1989) Acute and chronic ethanol treatment on beta-endorphin and catecholamine levels. Alcohol 6 : 59 63.
30. Penner CG, Gang G, Wray C, Fischer JE, Hasselgren PO (2001) The transcription factors NF-kappab and AP-1 are differentially regulated in skeletal muscle during sepsis. Biochem Biophys Res Commun 281 : 1331 1336.
31. Preedy VR, Keating JW, Peters TJ (1992) The acute effects of ethanol and acetaldehyde on rates of protein synthesis in type I and type II fibre-rich skeletal muscles of the rat. Alcohol Alcohol 27 : 241 251.
32. Preedy VR, Peters TJ (1988) The effect of chronic ethanol feeding on body and plasma composition and rates of skeletal muscle protein turnover in the rat. Alcohol Alcohol 23 : 217 224.
33. Preedy VR, Peters TJ (1990) The acute and chronic effects of ethanol on cardiac muscle protein synthesis in the rat in vivo. Alcohol 7 : 97 102.
34. Reiling JH, Hafen E (2004) The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev 18 : 2879 2892.
35. Reilly ME, Mantle D, Richardson PJ, Salisbury J, Jones J, Peters TJ, Preedy VR (1997) Studies on the time-course of ethanol's acute effects on skeletal muscle protein synthesis: comparison with acute changes in proteolytic activity. Alcohol Clin Exp Res 21 : 792 798.
36. Rice KM, Linderman JK, Kinnard RS, Blough ER (2005) The Fischer 344/NNiaHSd X Brown Norway/BiNia is a better model of sarcopenia than the Fischer 344/NNiaHSd: a comparative analysis of muscle mass and contractile properties in aging male rat models. Biogerontology 6 : 335 343.
37. Schwarzer R, Tondera D, Arnold W, Giese K, Klippel A, Kaufmann J (2005) REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase. Oncogene 24 : 1138 1149.
38. Shah OJ, Anthony JC, Kimball SR, Jefferson LS (2000) Glucocorticoids oppose translational control by leucine in skeletal muscle. Am J Physiol Endocrinol Metab 279 : E1185 E1190.
39. Sneddon AA, Koll M, Wallace MC, Jones J, Miell JP, Garlick PJ, Preedy VR (2003) Acute alcohol administration inhibits the refeeding response after starvation in rat skeletal muscle. Am J Physiol Endocrinol Metab 284 : E874 E882.
40. Sofer A, Lei K, Johannessen CM, Ellisen LW (2005) Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol 25 : 5834 5845.
41. Tiernan JM, Ward LC (1986) Acute effects of ethanol on protein synthesis in the rat. Alcohol Alcohol 21 : 171 179.
42. Vary TC, Nairn AC, Lang CH (2004) Restoration of protein synthesis in heart and skeletal muscle after withdrawal of alcohol. Alcohol Clin Exp Res 28 : 517 525.
43. Wang H, Kubica N, Ellisen LW, Jefferson LS, Kimball SR (2006) Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1. J Biol Chem 281 : 39128 39134.
44. Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124 : 471 484.