Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells

Neuroscience Letters

Volumn 439, Issue 2, 2008, Pages 125-128

  Shavali, Shaik ^a   Brown Borg, Holly M ^b   Ebadi, Manuchair ^b   Porter, James ^b  

^a UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b UNIVERSITY OF NORTH DAKOTA   (United States)

Author keywords

Alpha synuclein; Mitochondria; Neurodegeneration; Parkinson's disease

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA SYNUCLEIN; ROTENONE;

ARTICLE; BRAIN MITOCHONDRION; CELL LEVEL; CELL STRAIN HEK293; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; WESTERN BLOTTING; WILD TYPE;

ADENOSINE TRIPHOSPHATE; ALPHA-SYNUCLEIN; ANALYSIS OF VARIANCE; CELL LINE, TRANSFORMED; CYCLOOXYGENASE 1; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HUMANS; INSECTICIDES; MICROSCOPY, CONFOCAL; MITOCHONDRIA; ROTENONE; TRANSFECTION;

EID: 44649150145     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.05.005     Document Type: Article

References (21)

1. Dauer W., Kholodilov N., Vila M., Trillat A.C., Goodchild R., Larsen K.E., Staal R., Tieu K., Schmitz Y., Yuan C.A., Rocha M., Jackson-Lewis V., Hersch S., Sulzer D., Przedborski S., Burke R., and Hen R. Resistance of alpha-synuclein null mice to the Parkinsonian neurotoxin MPTP. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 14524-14529
2. +) toxicity and reduces dopamine transport. J. Neurosci. Res. 85 (2007) 351-363
3. Ghafourifar P., and Sen C.K. Mitochondrial nitric oxide synthase. Front Biosci. 12 (2007) 1072-1078
4. Hsu L.J., Sagara Y., Arroyo A., Rockenstein E., Sisk A., Mallory M., Wong J., Takenouchi T., Hashimoto M., and Masliah E. Alpha-synuclein promotes mitochondrial deficit and oxidative stress. Am. J. Pathol. 157 (2000) 401-410
5. Iwata A., Maruyama M., Kanazawa I., and Nukina N. Alpha-Synuclein affects the MAPK pathway and accelerates cell death. J. Biol. Chem. 276 (2001) 45320-45329
6. Junn E., and Mouradian M.M. Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine. Neurosci. Lett. 320 (2002) 146-150
7. Krüger R., Kuhn W., Müller T., Woitalla D., Graeber M., Kösel S., Przuntek H., Epplen J.T., Schöls L., and Riess O. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat. Genet. 18 (1998) 106-108
8. Li W.W., Yang R., Guo J.C., Ren H.M., Zha X.L., Cheng J.S., and Cai D.F. Localization of alpha-synuclein to mitochondria within midbrain of mice. Neuroreport 18 (2007) 1543-1546
9. Martin L.J., Pan Y., Price A.C., Sterling W., Copeland N.G., Jenkins N.A., Price D.L., and Lee M.K. Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J. Neurosci. 26 (2006) 41-50
10. Miller D.W., Hague S.M., Clarimon J., Baptista M., Gwinn-Hardy K., Cookson M.R., and Singleton A.B. Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication. Neurology 62 (2004) 1835-1838
11. Parihar M.S., Parihar A., Fujita M., Hashimoto M., and Ghafourifar P. Mitochondrial association of alpha-synuclein causes oxidative stress. Cell Mol. Life Sci. 65 (2008) 1272-1284
12. Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di Iorio G., Golbe L.I., and Nussbaum R.L. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276 (1997) 2045-2047
13. Przedborski S., and Ischiropoulos H. Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease. Antioxid. Redox Signal. 7 (2005) 685-693
14. Schapira A.H., Cooper J.M., Dexter D., Clark J.B., Jenner P., and Marsden C.D. Mitochondrial complex I deficiency in Parkinson's disease. J. Neurochem. 54 (1990) 823-827
15. Singleton A.B., Farrer M., Johnson J., Singleton A., Hague S., Kachergus J., Hulihan M., Peuralinna T., Dutra A., Nussbaum R., Lincoln S., Crawley A., Hanson M., Maraganore D., Adler C., Cookson M.R., Muenter M., Baptista M., Miller D., Blancato J., Hardy J., and Gwinn-Hardy K. Alpha-synuclein locus triplication causes Parkinson's disease. Science 320 (2003) 841
16. Shavali S., Carlson E.C., Swinscoe J.C., and Ebadi M. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline, a Parkinsonism-inducing endogenous toxin, increases alpha-synuclein expression and causes nuclear damage in human dopaminergic cells. J. Neurosci. Res. 76 (2004) 563-571
17. Song D.D., Shults C.W., Sisk A., Rockenstein E., and Masliah E. Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP. Exp. Neurol. 186 (2004) 158-172
18. Spillantini M.G., Schmidt M.L., Lee V.M., Trojanowski J.Q., Jakes R., and Goedert M. α-Synuclein in Lewy bodies. Nature 388 (1997) 839-840
19. Sun F., Anantharam V., Latchoumycandane C., Kanthasamy A., and Kanthasamy A.G. Dieldrin induces ubiquitin-proteasome dysfunction in alpha-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death. J. Pharmacol. Exp. Ther. 315 (2005) 69-79
20. Trimmer P.A., Swerdlow R.H., Parks J.K., Keeney P., Bennett Jr. J.P., Miller S.W., Davis R.E., and Parker Jr. W.D. Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines. Exp. Neurol. 162 (2000) 37-50
21. Vander Heiden M.G., Chandel N.S., Williamson E.K., Schumacker P.T., and Thompson C.B. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell 91 (1997) 627-637