Reactive γ-ketoaldehydes formed via the isoprostane pathway disrupt mitochondrial respiration and calcium homeostasis

Free Radical Biology and Medicine

Volumn 49, Issue 4, 2010, Pages 567-579

  Stavrovskaya, Irina G ^a,b   Baranov, Sergei V ^a,b   Guo, Xiaofeng ^a,b   Davies, Sean S ^c   Roberts, L Jackson ^c   Kristal, Bruce S ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ketoaldehydes; High resolution mass spectrometry; Lipid peroxidation; Mitochondrial permeability transition; Oxidative modification of cytochrome c; Oxidative stress

Indexed keywords

ALDEHYDE DERIVATIVE; CALCIUM ION; CYTOCHROME C; ISOPROSTANE; LYSINE; PYRIDINE NUCLEOTIDE; ZINC ION;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CALCIUM HOMEOSTASIS; CELL DEATH; CELL SWELLING; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME RELEASE; HEART MITOCHONDRION; LIPID PEROXIDATION; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; RAT;

ALDEHYDES; ANIMALS; CALCIUM; CELL DEATH; CELL RESPIRATION; HOMEOSTASIS; ISOPROSTANES; LIPID PEROXIDATION; MITOCHONDRIA, LIVER; RATS; RATS, INBRED BN; RATS, INBRED F344; STEREOISOMERISM;

EID: 77954562980     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.04.037     Document Type: Article

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