A dihydroselenoquinazoline inhibits S6 ribosomal protein signalling, induces apoptosis and inhibits autophagy in MCF-7 cells

European Journal of Pharmaceutical Sciences

Volumn 63, Issue , 2014, Pages 87-95

  Moreno, Esther ^a   Doughty Shenton, Dahlia ^b   Plano, Daniel ^a   Font, María ^a   Encío, Ignacio ^c   Palop, Juan Antonio ^a   Sanmartín, Carmen ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c PUBLIC UNIVERSITY OF NAVARRE   (Spain)

Author keywords

Apoptosis; Autophagy; Cell cycle arrest; Quinazoline; S6 ribosomal protein; Selenium

Indexed keywords

2,4 DIHYDROSELENOQUINAZOLINE; CAMPTOTHECIN; CASPASE 7; MAMMALIAN TARGET OF RAPAMYCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE B; PROTEIN P62; PROTEIN S6; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; 2,4-DIHYDROSELENOQUINAZOLINE; ORGANOSELENIUM DERIVATIVE;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL CYCLE ARREST; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; M PHASE CELL CYCLE CHECKPOINT; MCF 7 CELL LINE; MTT ASSAY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL CYCLE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; STRUCTURE ACTIVITY RELATION; TUMOR CELL CULTURE;

APOPTOSIS; AUTOPHAGY; CELL CYCLE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MCF-7 CELLS; MOLECULAR STRUCTURE; ORGANOSELENIUM COMPOUNDS; QUINAZOLINES; RIBOSOMAL PROTEIN S6; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84905036135     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.06.020     Document Type: Article

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