Synthesis and biological evaluation of 2,4,6-functionalized derivatives of pyrido[2,3-d]pyrimidines as cytotoxic agents and apoptosis inducers

Archiv der Pharmazie

Volumn 341, Issue 1, 2008, Pages 28-41

  Sanmartín, Carmen ^a   Domínguez, María Victoria ^a   Cordeu, Lucía ^a   Cubedo, Elena ^a   García Foncillas, Jesús ^a   Font, María ^a   Palop, Juan Antonio ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Apoptosis; Caspase 3; Cytotoxics; Pyridopyrimidines

Indexed keywords

2 (2 PROPYLSULFANYL) N PENTYLPYRIDO[2,3 DEXTRO]PYRIMIDINE 4 AMINE; 2 (ALKYLSULFANYL) N ALKYLPYRIDO[2,3 DEXTRO]PYRIMIDINE 4 AMINE DERIVATIVE; 2 (ETHYLSULFANYL) N HEXYLPYRIDO[2,3 DEXTRO]PYRIMIDINE 4 AMINE; 2 (ETHYLSULFANYL) N PENTYLPYRIDO[2,3 DEXTRO]PYRIMIDINE 4 AMINE; 2 (PENTYLSULFANYL) N HEXYLPYRIDO[2,3 DEXTRO]PYRIMIDINE 4 AMINE; 2 (PENTYLSULFANYL) N PENTYLPYRIDO[2,3 DEXTRO]PYRIMIDINE 4 AMINE; ANTINEOPLASTIC AGENT; CASPASE 3; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BLADDER CANCER; BREAST CANCER; COLON CANCER; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MODEL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; PYRIDINES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38949092467     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200700133     Document Type: Article

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