Synthesis of novel alkyltriazole tagged pyrido[2,3-d]pyrimidine derivatives and their anticancer activity

European Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2011, Pages 3462-3468

  Kurumurthy, C ^a   Sambasiva Rao, P ^a   Veera Swamy, B ^a   Santhosh Kumar, G ^a   Shanthan Rao, P ^a   Narsaiah, B ^a   Velatooru, L R ^a   Pamanji, R ^a   Venkateswara Rao, J ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Anticancer activity; Cyclisation; Perfluoroalkyl azides; Propargylation; Pyrido 2,3 d pyrimidine; Sharpless conditions

Indexed keywords

2 ETHYL 7 PHENYL 3 [[1 (3,3,4,4,5,5,6,6,7,7,8,8,8 TRIDECAFLUOROOCTYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5 (TRIFLUOROMETHYL) PYRIDO[2,3 D]PYRIMIDINE 4(3H)ONE; 2 ETHYL 7 PHENYL 4 [[1 (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10 HEPTADECAFLUORODECYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5 (TRIFLUOROMETHYL) PYRIDO[2,3 D]PYRIMIDINE 4(3H)ONE; 2 ISOPROPYL 7 PHENYL 4 [[1 (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10 HEPTADECAFLUORODECYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5 (TRIFLUOROMETHYL) PYRIDO[2,3 D]PYRIMIDINE 4(3H)ONE; 2 METHYL 7 PHENYL 3 [(1 PHENYL 1H 1,2,3 TRIAZOL 4 YL)METHYL] 5 (TRIFLUOROMETHYL) PYRIDO[2,3 D]PYRIMIDIN 4(3H) ONE; 2 METHYL 7 PHENYL 3 [[1 (3,3,4,4,5,5,6,6,7,7,8,8,8 TRIDECAFLUOROOCTYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5 (TRIFLUOROMETHYL) PYRIDO[2,3 D]PYRIMIDINE 4(3H)ONE; 2 N HEXYL 7 PHENYL 3 [[1 (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10 HEPTADECAFLUORODECYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 5 (TRIFLUOROMETHYL) PYRIDO[2,3 D]PYRIMIDINE 4(3H)ONE; 2,3 PYRIDINE; 3 [(1 DECYL 1H 1,2,3 TRIAZOL 4 YL)METHYL] 2 ETHYL 7 PHENYL 5 (TRIFLUOROMETHYL) PYRIDO[2,3 D]PYRIMIDINE 4(3H)ONE; 3 [(1 DECYL 1H 1,2,3 TRIAZOL 4 YL)METHYL] 2 METHYL 7 PHENYL 5 (TRIFLUOROMETHYL) PYRIDO[2,3 D]PYRIMIDINE 4(3H)ONE; 3 [(1 DECYL 1H 1,2,3 TRIAZOL 4 YL)METHYL] 7 PHENYL 5 (TRIFLUOROMETHYL) PYRIDO[2,3 D]PYRIMIDINE 4(3H)ONE; 3 [[1 (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10 HEPTADECAFLUORODECYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 2 HEXYL 7 PHENYL 5 (TRIFLUOROMETHYL) PYRIDO[2,3 D]PYRIMIDINE 4(3H)ONE; 3 [[1 (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10 HEPTADECAFLUORODECYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 2 ISOPROPYL 7 PHENYL 5 [TRIFLUOROMETHYL] PYRIDO[2,3 D]PYRIMIDINE 4(3H)ONE; 3 [[1 (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10 HEPTADECAFLUORODECYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 2 METHYL 7 PHENYL 5 [TRIFLUOROMETHYL] PYRIDO[2,3 D]PYRIMIDINE 4(3H)ONE; 3 [[1 (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10 HEPTADECAFLUORODECYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 7 PHENYL 5 (TRIFLUOROMETHYL) PYRIDO[2,3 D]PYRIMIDINE 4(3H)ONE; 4 [[1 (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10 HEPTADECAFLUORODECYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 2 METHYL 7 PHENYL 5 (TRIFLUOROMETHYL) PYRIDO[2,3 D]PYRIMIDINE 4(3H)ONE; 4 [[1 (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10 HEPTADECAFLUORODECYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL] 2,7 DIPHENYL 5 (TRIFLUOROMETHYL) PYRIDO[2,3 D]PYRIMIDINE 4(3H)ONE; ALKYLTRIAZOLE; ANTINEOPLASTIC AGENT; PYRIDINE DERIVATIVE; PYRIDO[2,3 D]PYRIMIDINE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL REACTION; CYCLIZATION; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

ALKYLATION; ANTINEOPLASTIC AGENTS; AZIDES; CELL LINE, TUMOR; CELL SURVIVAL; COLORECTAL NEOPLASMS; CYCLIZATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; LEUKEMIA, MONOCYTIC, ACUTE; LYMPHOMA; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 79958277858     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.011     Document Type: Article

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