A novel activation-induced suicidal degradation mechanism for Akt by selenium

International Journal of Molecular Medicine

Volumn 21, Issue 1, 2008, Pages 91-97

  Lee, Ji Hyun ^a,b   Shin, Sun Hye ^a   Kang, Seongman ^b   Lee, Yun Sil ^a   Bae, Sangwoo ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Korea University   (South Korea)

Author keywords

Activation induced degradation; Akt; Anti cancer; PTEN; Selenium

Indexed keywords

ALANINE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SELENOMETHIONINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME REGULATION; ENZYME STABILITY; GENE MUTATION; HUMAN; HUMAN CELL; LUNG CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DEPLETION; SIGNAL TRANSDUCTION;

EID: 38949111710     PISSN: 11073756     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijmm.21.1.91     Document Type: Article

References (18)

1. Combs GF Jr and Gray WP: Chemopreventive agents: selenium. Pharmacol Ther 79: 179-192, 1998.
2. Wang Z, Jiang C, Ganther H and Lu J: Antimitogenic and proapoptotic activities of methylseleninic acid in vascular endothelial cells and associated effects on PI3K-AKT, ERK, JNK and p38 MAPK signaling. Cancer Res 61: 7171-7178, 2001.
3. Chan TO, Rittenhouse SE and Tsichlis PN: AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem 68: 965-1014,1999.
4. Altomare DA and Testa JR: Perturbations of the AKT signaling pathway in human cancer. Oncogene 24: 7455-7464, 2005.
5. Di Cristofano A and Pandolfi PP: The multiple roles of PTEN in tumor suppression. Cell 100: 387-390, 2000.
6. Choi SY, Kim MJ, Kang CM, et al: Activation of Bak and Bax through c-Abl-protein kinaseCδ-p38 MAPK signaling in response to ionizing radiation in human non-small cell lung cancer cells. J Biol Chem 281: 7049-7059, 2006.
7. Basso AD, Solit DB, Chiosis G, Giri B, Tsichlis P and Rosen N: Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem 277: 39858-39866,2002.
8. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J and Dedhar S: Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci USA 95: 11211-11216, 1998.
9. Rokudai S, Fujita N, Hashimoto Y and Tsuruo T: Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis. J Cell Physiol 182: 290-296, 2000.
10. Xu J, Liu D and Songyang Z: The role of Asp-462 in regulating Akt activity. J Biol Chem 277: 35561-35566, 2002.
11. Zhang YW, Otterness DM, Chiang GG, et al: Genotoxic stress targets human ChkI for degradation by the ubiquitin-proteasome pathway. Mol Cell 19: 607-618, 2005.
12. Lu Z, Liu D, Hornia A, Devonish W, Pagano M and Fister DA: Activation of protein kinase C triggers its ubiquitination and degradation. Mol Cell Biol 18: 839-845, 1998.
13. Yang J, Cron P, Thompson V, et al: Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol Cell 9: 1227-1240, 2002,
14. Yuan XJ and Whang YE: PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway. Oncogene 21: 319-327, 2002.
15. Adachi M, Katsumura RK, Fujii K, Kobayashi S, Aoki H, and Matsuzaki M: Proteasome-dependent decrease in Akt by growth factors in vascular smooth muscle cells. FEBS Lett 554: 77-80, 2003.
16. Chun JY, Nadiminty N, Lee SO, Onate SA, Lou W and Gao AC: Mechanisms of selenium down-regulation of androgen receptor signaling in prostate cancer. Mol Cancer Ther 5: 913-918, 2006.
17. Bellacosa A, Kumar CC, Di Cristofano A and Testa JR: Activation of AKT kinases in cancer: implications for therapeutic targeting. Adv Cancer Res 94: 29-86, 2005.
18. Ip C: Lessons from basic research in selenium and cancer prevention. J Nutr 128: 1845-1854, 1998.