메뉴 건너뛰기




Volumn 11, Issue 1, 2013, Pages

Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells

Author keywords

iCRT 3; SOX4; Triple negative breast cancer; Wnt signaling pathway

Indexed keywords

ANTINEOPLASTIC AGENT; ESTROGEN RECEPTOR; GENISTEIN; INHIBITOR OF CATENIN RESPONSIVE TRANSCRIPTION 14; INHIBITOR OF CATENIN RESPONSIVE TRANSCRIPTION 3; INHIBITOR OF CATENIN RESPONSIVE TRANSCRIPTION 5; INHIBITOR OF WNT PRODUCTION 4; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR SOX4; UNCLASSIFIED DRUG; XAV 939;

EID: 84886734493     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-11-280     Document Type: Article
Times cited : (156)

References (41)
  • 1
    • 84855792427 scopus 로고    scopus 로고
    • Cancer statistics, 2012
    • 10.3322/caac.20138, 22237781
    • Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012, 62(1):10-29. 10.3322/caac.20138, 22237781.
    • (2012) CA Cancer J Clin , vol.62 , Issue.1 , pp. 10-29
    • Siegel, R.1    Naishadham, D.2    Jemal, A.3
  • 3
    • 34247569300 scopus 로고    scopus 로고
    • Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry
    • 10.1002/cncr.22618, 17387718
    • Bauer KR, Brown M, Cress RD, Parise CA, Caggiano V. Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry. Cancer 2007, 109(9):1721-1728. 10.1002/cncr.22618, 17387718.
    • (2007) Cancer , vol.109 , Issue.9 , pp. 1721-1728
    • Bauer, K.R.1    Brown, M.2    Cress, R.D.3    Parise, C.A.4    Caggiano, V.5
  • 8
    • 34247381115 scopus 로고    scopus 로고
    • Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer
    • 10.1200/JCO.2006.06.5664, 17116942
    • Haffty BG, Yang Q, Reiss M, Kearney T, Higgins SA, Weidhaas J, Harris L, Hait W, Toppmeyer D. Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer. J Clin Oncol 2006, 24(36):5652-5657. 10.1200/JCO.2006.06.5664, 17116942.
    • (2006) J Clin Oncol , vol.24 , Issue.36 , pp. 5652-5657
    • Haffty, B.G.1    Yang, Q.2    Reiss, M.3    Kearney, T.4    Higgins, S.A.5    Weidhaas, J.6    Harris, L.7    Hait, W.8    Toppmeyer, D.9
  • 9
    • 70849122251 scopus 로고    scopus 로고
    • Triple-negative breast cancer-current status and future directions
    • 10.1093/annonc/mdp492, 19901010
    • Gluz O, Liedtke C, Gottschalk N, Pusztai L, Nitz U, Harbeck N. Triple-negative breast cancer-current status and future directions. Ann Oncol 2009, 20(12):1913-1927. 10.1093/annonc/mdp492, 19901010.
    • (2009) Ann Oncol , vol.20 , Issue.12 , pp. 1913-1927
    • Gluz, O.1    Liedtke, C.2    Gottschalk, N.3    Pusztai, L.4    Nitz, U.5    Harbeck, N.6
  • 10
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • 10.1172/JCI45014, 3127435, 21633166
    • Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, Pietenpol JA. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011, 121(7):2750-2767. 10.1172/JCI45014, 3127435, 21633166.
    • (2011) J Clin Invest , vol.121 , Issue.7 , pp. 2750-2767
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3    Sanders, M.E.4    Chakravarthy, A.B.5    Shyr, Y.6    Pietenpol, J.A.7
  • 11
    • 80054101842 scopus 로고    scopus 로고
    • Molecular heterogeneity of triple-negative breast cancer and its clinical implications
    • 10.1097/CCO.0b013e32834bf8ae, 21986848
    • Irshad S, Ellis P, Tutt A. Molecular heterogeneity of triple-negative breast cancer and its clinical implications. Curr Opin Oncol 2011, 23(6):566-577. 10.1097/CCO.0b013e32834bf8ae, 21986848.
    • (2011) Curr Opin Oncol , vol.23 , Issue.6 , pp. 566-577
    • Irshad, S.1    Ellis, P.2    Tutt, A.3
  • 12
    • 80055040407 scopus 로고    scopus 로고
    • FZD7 has a critical role in cell proliferation in triple negative breast cancer
    • 10.1038/onc.2011.145, 21532620
    • Yang L, Wu X, Wang Y, Zhang K, Wu J, Yuan YC, Deng X, Chen L, Kim CC, Lau S, et al. FZD7 has a critical role in cell proliferation in triple negative breast cancer. Oncogene 2011, 30(43):4437-4446. 10.1038/onc.2011.145, 21532620.
    • (2011) Oncogene , vol.30 , Issue.43 , pp. 4437-4446
    • Yang, L.1    Wu, X.2    Wang, Y.3    Zhang, K.4    Wu, J.5    Yuan, Y.C.6    Deng, X.7    Chen, L.8    Kim, C.C.9    Lau, S.10
  • 14
    • 3142590865 scopus 로고    scopus 로고
    • Wnt signaling and breast cancer
    • 10.4161/cbt.3.1.561, 14739782
    • Howe LR, Brown AM. Wnt signaling and breast cancer. Cancer Biol Ther 2004, 3(1):36-41. 10.4161/cbt.3.1.561, 14739782.
    • (2004) Cancer Biol Ther , vol.3 , Issue.1 , pp. 36-41
    • Howe, L.R.1    Brown, A.M.2
  • 15
    • 77953183234 scopus 로고    scopus 로고
    • Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
    • 10.2353/ajpath.2010.091125, 2877852, 20395444
    • Khramtsov AI, Khramtsova GF, Tretiakova M, Huo D, Olopade OI, Goss KH. Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome. Am J Pathol 2010, 176(6):2911-2920. 10.2353/ajpath.2010.091125, 2877852, 20395444.
    • (2010) Am J Pathol , vol.176 , Issue.6 , pp. 2911-2920
    • Khramtsov, A.I.1    Khramtsova, G.F.2    Tretiakova, M.3    Huo, D.4    Olopade, O.I.5    Goss, K.H.6
  • 16
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: components, mechanisms, and diseases
    • 10.1016/j.devcel.2009.06.016, 2861485, 19619488
    • MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009, 17(1):9-26. 10.1016/j.devcel.2009.06.016, 2861485, 19619488.
    • (2009) Dev Cell , vol.17 , Issue.1 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 19
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • 10.1038/nrc2389, 18432252
    • Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer 2008, 8(5):387-398. 10.1038/nrc2389, 18432252.
    • (2008) Nat Rev Cancer , vol.8 , Issue.5 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 20
    • 0036696817 scopus 로고    scopus 로고
    • Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families
    • 10.1016/S1534-5807(02)00223-X, 12194848
    • Schepers GE, Teasdale RD, Koopman P. Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. Dev Cell 2002, 3(2):167-170. 10.1016/S1534-5807(02)00223-X, 12194848.
    • (2002) Dev Cell , vol.3 , Issue.2 , pp. 167-170
    • Schepers, G.E.1    Teasdale, R.D.2    Koopman, P.3
  • 21
    • 58349101326 scopus 로고    scopus 로고
    • Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cells
    • 10.1158/0008-5472.CAN-08-3415, 2629396, 19147588
    • Scharer CD, McCabe CD, Ali-Seyed M, Berger MF, Bulyk ML, Moreno CS. Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cells. Cancer Res 2009, 69(2):709-717. 10.1158/0008-5472.CAN-08-3415, 2629396, 19147588.
    • (2009) Cancer Res , vol.69 , Issue.2 , pp. 709-717
    • Scharer, C.D.1    McCabe, C.D.2    Ali-Seyed, M.3    Berger, M.F.4    Bulyk, M.L.5    Moreno, C.S.6
  • 22
    • 0036668285 scopus 로고    scopus 로고
    • Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators
    • 10.1016/S0959-437X(02)00323-4, 12100890
    • Wilson M, Koopman P. Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators. Curr Opin Genet Dev 2002, 12(4):441-446. 10.1016/S0959-437X(02)00323-4, 12100890.
    • (2002) Curr Opin Genet Dev , vol.12 , Issue.4 , pp. 441-446
    • Wilson, M.1    Koopman, P.2
  • 23
    • 36048993973 scopus 로고    scopus 로고
    • Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells
    • 10.1128/MCB.02179-06, 2169141, 17875931
    • Sinner D, Kordich JJ, Spence JR, Opoka R, Rankin S, Lin SC, Jonatan D, Zorn AM, Wells JM. Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol Cell Biol 2007, 27(22):7802-7815. 10.1128/MCB.02179-06, 2169141, 17875931.
    • (2007) Mol Cell Biol , vol.27 , Issue.22 , pp. 7802-7815
    • Sinner, D.1    Kordich, J.J.2    Spence, J.R.3    Opoka, R.4    Rankin, S.5    Lin, S.C.6    Jonatan, D.7    Zorn, A.M.8    Wells, J.M.9
  • 25
    • 78651376176 scopus 로고    scopus 로고
    • Sox4 stimulates beta-catenin activity through induction of CK2
    • Lee AK, Ahn SG, Yoon JH, Kim SA. Sox4 stimulates beta-catenin activity through induction of CK2. Oncol Rep 2011, 25(2):559-565.
    • (2011) Oncol Rep , vol.25 , Issue.2 , pp. 559-565
    • Lee, A.K.1    Ahn, S.G.2    Yoon, J.H.3    Kim, S.A.4
  • 26
    • 0033855919 scopus 로고    scopus 로고
    • The therapeutic potential of flavonoids
    • 10.1517/13543784.9.9.2103, 11060796
    • Wang HK. The therapeutic potential of flavonoids. Expert Opin Investig Drugs 2000, 9(9):2103-2119. 10.1517/13543784.9.9.2103, 11060796.
    • (2000) Expert Opin Investig Drugs , vol.9 , Issue.9 , pp. 2103-2119
    • Wang, H.K.1
  • 27
    • 0028910254 scopus 로고
    • Biochemical targets of the isoflavone genistein in tumor cell lines
    • 10.3181/00379727-208-43840, 7892283
    • Barnes S, Peterson TG. Biochemical targets of the isoflavone genistein in tumor cell lines. Proc Soc Exp Biol Med 1995, 208(1):103-108. 10.3181/00379727-208-43840, 7892283.
    • (1995) Proc Soc Exp Biol Med , vol.208 , Issue.1 , pp. 103-108
    • Barnes, S.1    Peterson, T.G.2
  • 28
    • 0242496947 scopus 로고    scopus 로고
    • Soy isoflavones and cancer prevention
    • 10.1081/CNV-120023773, 14628433
    • Sarkar FH, Li Y. Soy isoflavones and cancer prevention. Cancer Invest 2003, 21(5):744-757. 10.1081/CNV-120023773, 14628433.
    • (2003) Cancer Invest , vol.21 , Issue.5 , pp. 744-757
    • Sarkar, F.H.1    Li, Y.2
  • 29
    • 55549148757 scopus 로고    scopus 로고
    • Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells
    • 10.1074/jbc.M802759200, 2562074, 18687691
    • Li Y, Wang Z, Kong D, Li R, Sarkar SH, Sarkar FH. Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells. J Biol Chem 2008, 283(41):27707-27716. 10.1074/jbc.M802759200, 2562074, 18687691.
    • (2008) J Biol Chem , vol.283 , Issue.41 , pp. 27707-27716
    • Li, Y.1    Wang, Z.2    Kong, D.3    Li, R.4    Sarkar, S.H.5    Sarkar, F.H.6
  • 30
    • 69049087664 scopus 로고    scopus 로고
    • Cellular signaling perturbation by natural products
    • 10.1016/j.cellsig.2009.03.009, 2756420, 19298854
    • Sarkar FH, Li Y, Wang Z, Kong D. Cellular signaling perturbation by natural products. Cell Signal 2009, 21(11):1541-1547. 10.1016/j.cellsig.2009.03.009, 2756420, 19298854.
    • (2009) Cell Signal , vol.21 , Issue.11 , pp. 1541-1547
    • Sarkar, F.H.1    Li, Y.2    Wang, Z.3    Kong, D.4
  • 31
    • 60149095682 scopus 로고    scopus 로고
    • Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates beta-catenin signaling in mammary epithelial cells
    • Su Y, Simmen RC. Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates beta-catenin signaling in mammary epithelial cells. Carcinogenesis 2009, 30(2):331-339.
    • (2009) Carcinogenesis , vol.30 , Issue.2 , pp. 331-339
    • Su, Y.1    Simmen, R.C.2
  • 32
    • 34447289163 scopus 로고    scopus 로고
    • Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors
    • 10.1152/physiolgenomics.00023.2007, 17341692
    • Su Y, Simmen FA, Xiao R, Simmen RC. Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors. Physiol Genomics 2007, 30(1):8-16. 10.1152/physiolgenomics.00023.2007, 17341692.
    • (2007) Physiol Genomics , vol.30 , Issue.1 , pp. 8-16
    • Su, Y.1    Simmen, F.A.2    Xiao, R.3    Simmen, R.C.4
  • 33
    • 77950855926 scopus 로고    scopus 로고
    • Effects of genistein on beta-catenin signaling and subcellular distribution of actin-binding proteins in human umbilical CD105-positive stromal cells
    • Shieh DB, Li RY, Liao JM, Chen GD, Liou YM. Effects of genistein on beta-catenin signaling and subcellular distribution of actin-binding proteins in human umbilical CD105-positive stromal cells. J Cell Physiol 2010, 223(2):423-434.
    • (2010) J Cell Physiol , vol.223 , Issue.2 , pp. 423-434
    • Shieh, D.B.1    Li, R.Y.2    Liao, J.M.3    Chen, G.D.4    Liou, Y.M.5
  • 34
    • 77955503750 scopus 로고    scopus 로고
    • Inhibition of beta-catenin/Tcf signaling by flavonoids
    • 10.1002/jcb.22654, 20564233
    • Park S, Choi J. Inhibition of beta-catenin/Tcf signaling by flavonoids. J Cell Biochem 2010, 110(6):1376-1385. 10.1002/jcb.22654, 20564233.
    • (2010) J Cell Biochem , vol.110 , Issue.6 , pp. 1376-1385
    • Park, S.1    Choi, J.2
  • 35
    • 79955046668 scopus 로고    scopus 로고
    • An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway
    • 10.1073/pnas.1017496108, 3076864, 21393571
    • Gonsalves FC, Klein K, Carson BB, Katz S, Ekas LA, Evans S, Nagourney R, Cardozo T, Brown AM, DasGupta R. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci U S A 2011, 108(15):5954-5963. 10.1073/pnas.1017496108, 3076864, 21393571.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.15 , pp. 5954-5963
    • Gonsalves, F.C.1    Klein, K.2    Carson, B.B.3    Katz, S.4    Ekas, L.A.5    Evans, S.6    Nagourney, R.7    Cardozo, T.8    Brown, A.M.9    DasGupta, R.10
  • 37
    • 58249122326 scopus 로고    scopus 로고
    • Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
    • 10.1038/nchembio.137, 2628455, 19125156
    • Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, Wei S, Hao W, Kilgore J, Williams NS, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 2009, 5(2):100-107. 10.1038/nchembio.137, 2628455, 19125156.
    • (2009) Nat Chem Biol , vol.5 , Issue.2 , pp. 100-107
    • Chen, B.1    Dodge, M.E.2    Tang, W.3    Lu, J.4    Ma, Z.5    Fan, C.W.6    Wei, S.7    Hao, W.8    Kilgore, J.9    Williams, N.S.10
  • 39
    • 68049085887 scopus 로고    scopus 로고
    • In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models
    • 10.1158/1078-0432.CCR-09-0317, 19567590
    • Hoeflich KP, OBrien C, Boyd Z, Cavet G, Guerrero S, Jung K, Januario T, Savage H, Punnoose E, Truong T, et al. In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models. Clin Cancer Res 2009, 15(14):4649-4664. 10.1158/1078-0432.CCR-09-0317, 19567590.
    • (2009) Clin Cancer Res , vol.15 , Issue.14 , pp. 4649-4664
    • Hoeflich, K.P.1    OBrien, C.2    Boyd, Z.3    Cavet, G.4    Guerrero, S.5    Jung, K.6    Januario, T.7    Savage, H.8    Punnoose, E.9    Truong, T.10
  • 41
    • 0035942271 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • 10.1073/pnas.091062498, 33173, 11309499
    • Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 2001, 98(9):5116-5121. 10.1073/pnas.091062498, 33173, 11309499.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.9 , pp. 5116-5121
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.