Synthesis and biological evaluation of new symmetrical derivatives as cytotoxic agents and apoptosis inducers

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 6, 2005, Pages 2031-2044

  Sanmartín, Carmen ^a   Echeverría, Mikel ^a   Mendívil, Beatriz ^a   Cordeu, Lucía ^b   Cubedo, Elena ^b   García Foncillas, Jesús ^b   Font, María ^a   Palop, Juan Antonio ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Amides and amines; Apoptosis; Carbamates; Caspase 3; Cytotoxics; Symmetrical ethers; Ureas

Indexed keywords

1,4 BIS(3 PHENYLPROPYL)PIPERAZINE; 2,2' [METHYLENEBIS(1,4 PHENYLOXYMETHYLENE)]DIPYRIDINE; 4 METHOXY N [3 [[(4 METHOXY 7 NITROQUINOLIN 2 YL)CARBONYL]AMINO]PROPYL] 5 NITROQUINOLINE 2 CARBOXAMIDE; 4,4' METHYLENEBIS(N BENZYLANILINE); 4,4' METHYLENEBIS[N (4 NITROBENZYL)ANILINE]; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CASPASE 3; CYTOTOXIC AGENT; DNA FRAGMENT; METHYLENEBIS[(4 CHLORO 2,1 PHENYLENE) N (4 NITROPHENYL)CARBAMATE]; METHYLENEBIS[(4,1 PHENYLENE) N (2 CHLOROETHYL)CARBAMATE]; METHYLENEBIS[(4,1 PHENYLENE) N (4 NITROPHENYL)CARBAMATE]; METHYLENEBIS[N (4,1 PHENYLENE) N' (2 CHLOROETHYL)UREA]; METHYLENEBIS[N (4,1 PHENYLENE) N' (4 NITROPHENYL)UREA]; METHYLENEBIS[N (4,1 PHENYLENE) N' (NAPHTH 1 YL)UREA]; METHYLENEBIS[N (4,1 PHENYLENE) N' (PROPYL)UREA]; N,N' BIS(2 PYRIDIN 2 YLETHYL)PYRIDO[2,3 D]PYRIMIDINE 2,4 DIAMINE; N,N' BIS[2 (1H INDOL 3 YL)ETHYL]PYRIDO[2,3 D]PYRIMIDINE 2,4 DIAMINE; N,N' DIPYRIDO[2,3 D]PYRIMIDIN 4 YLOCTANE 1,8 DIAMINE; N,N' DODECANE 1,12 DIYLDINICOTINAMIDE; N,N' PROPANE 1,3 DIYLDIQUINOLINE 3 CARBOXAMIDE; PENTANE 1,5 DIYLBIS[N (4 NITROPHENYL)CARBAMATE]; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INDUCTION; FRAGMENTATION REACTION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; STRUCTURE ANALYSIS;

STAPHYLOCOCCUS PHAGE 3A;

EID: 13844310288     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.01.008     Document Type: Article

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