Mitochondrial trafficking in neuropsychiatric diseases

Neurobiology of Disease

Volumn 51, Issue , 2013, Pages 66-71

  Deheshi, Samineh ^a   Pasqualotto, Bryce A ^a   Rintoul, Gordon L ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

Author keywords

Alzheimer's disease; Depression; Mitochondria; Mitochondrial trafficking; Mitochondrial transport; Neuropsychiatric disorders; Schizophrenia

Indexed keywords

AMYLOID BETA PROTEIN; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; FASCICULATION AND ELONGATION PROTEIN ZETA 1; REGULATOR PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; CELL MIGRATION; CELL TRANSPORT; DEPRESSION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HUMAN; MITOCHONDRIAL DYNAMICS; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN UNFOLDING; REVIEW; RNA INTERFERENCE; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; MENTAL DISORDERS; MITOCHONDRIA; NEURODEGENERATIVE DISEASES; NEURONS;

EID: 84872679331     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2012.06.015     Document Type: Review

References (114)

1. Atkin T.A., et al. Disrupted in schizophrenia-1 regulates intracellular trafficking of mitochondria in neurons. Mol. Psychiatry 2011, 16(122-4):121.
2. Baloh R.H., et al. Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations. J. Neurosci. 2007, 27:422-430.
3. Baughman J.M., et al. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature 2011, 476:341-345.
4. Belmaker R.H., Agam G. Major depressive disorder. N. Engl. J. Med. 2008, 358:55-68.
5. Berridge M.J., et al. Calcium-a life and death signal. Nature 1998, 395:645-648.
6. Bertolino A., et al. Regionally specific neuronal pathology in untreated patients with schizophrenia: a proton magnetic resonance spectroscopic imaging study. Biol. Psychiatry 1998, 43:641-648.
7. Bloom L., Horvitz H.R. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:3414-3419.
8. Brandon N.J., Sawa A. Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat. Rev. Neurosci. 2011, 12:707-722.
9. Brandon N.J., et al. Understanding the role of DISC1 in psychiatric disease and during normal development. J. Neurosci. 2009, 29:12768-12775.
10. Braschi E., McBride H.M. Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism. Bioessays 2010, 32:958-966.
11. Cai Q., Sheng Z.H. Mitochondrial transport and docking in axons. Exp. Neurol. 2009, 218:257-267.
12. Calkins M.J., Reddy P.H. Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons. Biochim. Biophys. Acta 2011, 1812:507-513.
13. Calkins M.J., et al. Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease. Hum. Mol. Genet. 2011, 20:4515-4529.
14. Caspersen C., et al. Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease. FASEB J. 2005, 19:2040-2041.
15. Chakos M.H., et al. Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia. Br. J. Psychiatry 2005, 186:26-31.
16. Chang D., Reynolds I. Mitochondrial trafficking and morphology in healthy and injured neurons. Prog. Neurobiol. 2006, 80:241-268.
17. Chang D.T., et al. Mitochondrial trafficking to synapses in cultured primary cortical neurons. J. Neurosci. 2006, 26:7035-7045.
18. Chang D.T., et al. Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons. Neurobiol. Dis. 2006, 22:388-400.
19. Chang D.T.W., et al. Mitochondrial trafficking to synapses in cultured primary cortical. J. Neurosci. 2006, 26:7035-7045.
20. Chen S., et al. Serotonin stimulates mitochondrial transport in hippocampal neurons. Mol. Cell. Neurosci. 2007, 36:472-483.
21. Cheung E.C., et al. Mitochondrial dynamics in the regulation of neuronal cell death. Apoptosis 2007, 12:979-992.
22. Chinopoulos C., Adam-Vizi V. Mitochondrial Ca2+ sequestration and precipitation revisited. FEBS J. 2010, 277:3637-3651.
23. Cho D.H., et al. Mitochondrial dynamics in cell death and neurodegeneration. Cell. Mol. Life Sci. 2010, 67:3435-3447.
24. Chubb J.E., et al. The DISC locus in psychiatric illness. Mol. Psychiatry 2008, 13:36-64.
25. Clay H.B., et al. Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia. Int. J. Dev. Neurosci. 2011, 29:311-324.
26. Colzi A., et al. Monoamine oxidase-A inhibitors and dopamine metabolism in rat caudatus: evidence that an increased cytosolic level of dopamine displaces reversible monoamine oxidase-A inhibitors in vivo. J. Pharmacol. Exp. Ther. 1993, 265:103-111.
27. Curtis D., et al. Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q. Psychiatr. Genet. 2003, 13:77-84.
28. De Stefani D., et al. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature 2011, 476:336-340.
29. Decker H., et al. Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons. J. Neurosci. 2010, 30:9166-9171.
30. Detmer S.A., Chan D.C. Functions and dysfunctions of mitochondrial dynamics. Nat. Rev. Mol. Cell Biol. 2007, 8:870-879.
31. Dixit R., et al. Differential regulation of dynein and kinesin motor proteins by tau. Science 2008, 319:1086-1089.
32. Du H., et al. Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:18670-18675.
33. Duan X., et al. Disrupted-in-schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell 2007, 130:1146-1158.
34. Ebneth A., et al. Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease. J. Cell Biol. 1998, 143:777-794.
35. Frank S., et al. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev. Cell 2001, 1:515-525.
36. Fujita T., et al. Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells. Biochem. Biophys. Res. Commun. 2007, 361:605-610.
37. Gabaldon T., Huynen M.A. From endosymbiont to host-controlled organelle: the hijacking of mitochondrial protein synthesis and metabolism. PLoS Comput. Biol. 2007, 3:e219.
38. Garey L.J., et al. Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia. J. Neurol. Neurosurg. Psychiatry 1998, 65:446-453.
39. Gindhart J.G., et al. The kinesin-associated protein UNC-76 is required for axonal transport in the Drosophila nervous system. Mol. Biol. Cell 2003, 14:3356-3365.
40. Glantz L.A., Lewis D.A. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch. Gen. Psychiatry 2000, 57:65-73.
41. Glenner G.G., Wong C.W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 1984, 120:885-890.
42. Goedert M., Spillantini M.G. A century of Alzheimer's disease. Science 2006, 314:777-781.
43. Graeber M.B., et al. Rediscovery of the case described by Alois Alzheimer in 1911: historical, histological and molecular genetic analysis. Neurogenetics 1997, 1:73-80.
44. Grundke-Iqbal I., et al. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J. Biol. Chem. 1986, 261:6084-6089.
45. Grundke-Iqbal I., et al. Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments. Brain Res. 1988, 464:43-52.
46. Gur R.E., et al. A follow-up magnetic resonance imaging study of schizophrenia. Relationship of neuroanatomical changes to clinical and neurobehavioral measures. Arch. Gen. Psychiatry 1998, 55:145-152.
47. Hennah W., et al. Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects. Hum. Mol. Genet. 2003, 12:3151-3159.
48. Hollenbeck P.J., Saxton W.M. The axonal transport of mitochondria. J. Cell Sci. 2005, 118:5411-5419.
49. Ikuta J., et al. Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility. Biochem. Biophys. Res. Commun. 2007, 353:127-132.
50. Ittner L.M., Gotz J. Amyloid-beta and tau-a toxic pas de deux in Alzheimer's disease. Nat. Rev. Neurosci. 2011, 12:65-72.
51. Jahani-Asl A., et al. Mitochondria: joining forces to thwart cell death. Biochim. Biophys. Acta 2010, 1802:162-166.
52. James R., et al. Disrupted in schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria. Mol. Cell. Neurosci. 2004, 26:112-122.
53. Kamiya A., et al. A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nat. Cell Biol. 2005, 7:1167-1178.
54. Kanaan N.M., et al. Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. J. Neurosci. 2011, 31:9858-9868.
55. Karbowski M., Youle R.J. Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death Differ. 2003, 10:870-880.
56. Kuroda S., et al. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein. J. Cell Biol. 1999, 144:403-411.
57. Lewis M.R., Lewis W.R. Mitochondria (and other cytoplasmic structures) in tissue cultures. Am. J. Anat. 1915, 17:339-401.
58. Lewis D.A., Levitt P. Schizophrenia as a disorder of neurodevelopment. Annu. Rev. Neurosci. 2002, 25:409-432.
59. Lewis D.A., Lieberman J.A. Catching up on schizophrenia: natural history and neurobiology. Neuron 2000, 28:325-334.
60. Li Z., et al. The importance of dendritic mitochondria in the morphogenesis and. Cell 2004, 119:873-887.
61. Ligon L.A., Steward O. Movement of mitochondria in the axons and dendrites of cultured hippocampal neurons. J. Comp. Neurol. 2000, 427:340-350.
62. Ligon L.A., Steward O. Role of microtubules and actin filaments in the movement of mitochondria in the axons and dendrites of cultured hippocampal neurons. J. Comp. Neurol. 2000, 427:351-361.
63. Lin M.T., Beal M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006, 443:787-795.
64. MacAskill A.F., Kittler J.T. Control of mitochondrial transport and localization in neurons. Trends Cell Biol. 2010, 20:102-112.
65. Maccioni R.B., et al. The molecular bases of Alzheimer's disease and other neurodegenerative disorders. Arch. Med. Res. 2001, 32:367-381.
66. Malaiyandi L.M., et al. Zn2+ inhibits mitochondrial movement in neurons by phosphatidylinositol 3-kinase activation. J. Neurosci. 2005, 25:9507-9514.
67. Mandell J.W., Banker G.A. A spatial gradient of tau protein phosphorylation in nascent axons. J. Neurosci. 1996, 16:5727-5740.
68. Marinkovic P., et al. Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:4296-4301.
69. Masters C.L., et al. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl. Acad. Sci. U. S. A. 1985, 82:4245-4249.
70. Millar J.K., et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum. Mol. Genet. 2000, 9:1415-1423.
71. Millar J.K., et al. Disrupted in schizophrenia 1 (DISC1): subcellular targeting and induction of ring mitochondria. Mol. Cell. Neurosci. 2005, 30:477-484.
72. Miyoshi K., et al. Disrupted-in-schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol. Psychiatry 2003, 8:685-694.
73. Moreau B., et al. Biphasic regulation of mitochondrial Ca2+ uptake by cytosolic Ca2+ concentration. Curr. Biol. 2006, 16:1672-1677.
74. Morfini G.A., et al. Axonal transport defects in neurodegenerative diseases. J. Neurosci. 2009, 29:12776-12786.
75. Morishima-Kawashima M., Ihara Y. Alzheimer's disease: beta-amyloid protein and tau. J. Neurosci. Res. 2002, 70:392-401.
76. Morris R.L., Hollenbeck P.J. Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons. J. Cell Biol. 1995, 131:1315-1326.
77. Morris J.A., et al. DISC1 (disrupted-in-schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Hum. Mol. Genet. 2003, 12:1591-1608.
78. Morris M., et al. The many faces of tau. Neuron 2011, 70:410-426.
79. Nicholls D.G. Mitochondria and calcium signaling. Cell Calcium 2005, 38:311-317.
80. Overly C.C., et al. Organelle motility and metabolism in axons vs dendrites of cultured. J. Cell Sci. 1996, 109(Pt 5):971-980.
81. Pantelis C., et al. Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet 2003, 361:281-288.
82. Pigino G., et al. Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J. Neurosci. 2003, 23:4499-4508.
83. Pigino G., et al. Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:5907-5912.
84. Pilling A.D., et al. Kinesin-1 and dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. Mol. Biol. Cell 2006, 17:2057-2068.
85. Pivovarova N.B., Andrews S.B. Calcium-dependent mitochondrial function and dysfunction in neurons. FEBS J. 2010, 277:3622-3636.
86. Rambold A.S., et al. Together we are stronger: fusion protects mitochondria from autophagosomal degradation. Autophagy 2011, 7.
87. Rapoport J.L., et al. Childhood-onset schizophrenia. Progressive ventricular change during adolescence. Arch. Gen. Psychiatry 1997, 54:897-903.
88. Rapoport J.L., et al. Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study. Arch. Gen. Psychiatry 1999, 56:649-654.
89. Reddy P.H. Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease. Brain Res. 2011, 1415:136-148.
90. Rezin G.T., et al. Mitochondrial dysfunction and psychiatric disorders. Neurochem. Res. 2009, 34:1021-1029.
91. Rintoul G.L., Reynolds I.J. Mitochondrial trafficking and morphology in neuronal injury. Biochim. Biophys. Acta 2010, 1802:143-150.
92. Rintoul G.L., et al. Glutamate decreases mitochondrial size and movement in primary forebrain neurons. J. Neurosci. 2003, 23:7881-7888.
93. Rintoul G.L., et al. Nitric oxide inhibits mitochondrial movement in forebrain neurons associated with disruption of mitochondrial membrane potential. J. Neurochem. 2006, 97:800-806.
94. Roy S., et al. Axonal transport defects: a common theme in neurodegenerative diseases. Acta Neuropathol. 2005, 109:5-13.
95. Rui Y., et al. Acute impairment of mitochondrial trafficking by beta-amyloid peptides in hippocampal neurons. J. Neurosci. 2006, 26:10480-10487.
96. Rui Y., et al. Inhibition of AMPA receptor trafficking at hippocampal synapses by beta-amyloid oligomers: the mitochondrial contribution. Mol. Brain 2010, 3:10.
97. Rund B.R. Is schizophrenia a neurodegenerative disorder?. Nord. J. Psychiatry 2009, 63:196-201.
98. Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 2001, 81:741-766.
99. Sheng Z.H., Cai Q. Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. Nat. Rev. Neurosci. 2012, 13:77-93.
100. Shinoda T., et al. DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2. J. Neurosci. 2007, 27:4-14.
101. Sjoerdsma A., et al. Metabolism of 5-hydroxytryptamine (serotonin) by monoamine oxidase. Proc. Soc. Exp. Biol. Med. 1955, 89:36-38.
102. Soares D.C., et al. DISC1: structure, function, and therapeutic potential for major mental illness. ACS Chem. Neurosci. 2011, 2:609-632.
103. Sporn A.L., et al. Progressive brain volume loss during adolescence in childhood-onset schizophrenia. Am. J. Psychiatry 2003, 160:2181-2189.
104. Stoothoff W.H., Johnson G.V.W. Tau phosphorylation: physiological and pathological consequences. Biochim. Biophys. Acta 2005, 1739:280-297.
105. Stout A.K., et al. Glutamate-induced neuron death requires mitochondrial calcium uptake. Nat. Neurosci. 1998, 1:366-373.
106. Taya S., et al. DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. J. Neurosci. 2007, 27:15-26.
107. Vallee R.B., Bloom G.S. Mechanisms of fast and slow axonal transport. Annu. Rev. Neurosci. 1991, 14:59-92.
108. Vande Velde C., et al. Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset. PLoS One 2011, 6:e22031.
109. Vaux D.L. Apoptogenic factors released from mitochondria. Biochim. Biophys. Acta 2011, 1813:546-550.
110. Vossel K.A., et al. Tau reduction prevents Abeta-induced defects in axonal transport. Science 2010, 330:198.
111. Wang X., et al. Amyloid-beta-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons. Neurodegener. Dis. 2010, 7:56-59.
112. Wilson T.J., et al. Cell signaling and mitochondrial dynamics: implications for neuronal function and neurodegenerative disease. Neurobiol. Dis. 2013, 51:13-26.
113. Wischik C.M., et al. Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. Proc. Natl. Acad. Sci. U. S. A. 1988, 85:4506-4510.
114. Youle R.J., van der Bliek A.M. Mitochondrial fission, fusion, and stress. Science 2012, 337:1062-1065.