메뉴 건너뛰기




Volumn 42, Issue 1, 2000, Pages 5-10

(±)3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: Studies in animals

Author keywords

Amphetamines; MDMA; Monkeys; Neurotoxicity; Serotonin

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; BRAIN MONOAMINE; SEROTONIN; SEROTONIN RECEPTOR AFFECTING AGENT;

EID: 0033623773     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000026664     Document Type: Article
Times cited : (274)

References (50)
  • 1
    • 0022357597 scopus 로고
    • Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals
    • Ricaurte GA, Bryan G, Strauss L, Seiden LS, Schuster CR: Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals. Science 1985;229:986-988.
    • (1985) Science , vol.229 , pp. 986-988
    • Ricaurte, G.A.1    Bryan, G.2    Strauss, L.3    Seiden, L.S.4    Schuster, C.R.5
  • 2
    • 0022486506 scopus 로고
    • Methylenedioxymethamphetamine: A potentially neurotoxic amphetamine analog
    • Schmidt CJ, Wu L, Lovenberg W: Methylenedioxymethamphetamine: A potentially neurotoxic amphetamine analog. Eur J Pharmacol 1986;124:175-178.
    • (1986) Eur J Pharmacol , vol.124 , pp. 175-178
    • Schmidt, C.J.1    Wu, L.2    Lovenberg, W.3
  • 3
    • 0022911033 scopus 로고
    • The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain
    • Stone DM, Stahl DC, Hanson GR, Gibb JW: The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain. Eur J Pharmacol 1986; 128:41-48.
    • (1986) Eur J Pharmacol , vol.128 , pp. 41-48
    • Stone, D.M.1    Stahl, D.C.2    Hanson, G.R.3    Gibb, J.W.4
  • 4
    • 0023255308 scopus 로고
    • Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain
    • Commins DL, Vosmer G, Virus R, Woolverton W, Schuster C, Seiden L: Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain. J Pharmacol Exp Ther 1987;241:338-345.
    • (1987) J Pharmacol Exp Ther , vol.241 , pp. 338-345
    • Commins, D.L.1    Vosmer, G.2    Virus, R.3    Woolverton, W.4    Schuster, C.5    Seiden, L.6
  • 5
    • 0023163857 scopus 로고
    • Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine
    • Schmidt CJ: Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. J Pharmacol Exp Ther 1987;240:1-7.
    • (1987) J Pharmacol Exp Ther , vol.240 , pp. 1-7
    • Schmidt, C.J.1
  • 6
    • 0023819569 scopus 로고
    • (±)3,4-Methylenedioxymethamphetamine (MDMA) selectively damages central serotonergic neurons in nonhuman primates
    • Ricaurte GA, Forno LS, Wilson MA, DeLanney LE, Irwin I, Molliver ME, et al: (±)3,4-Methylenedioxymethamphetamine (MDMA) selectively damages central serotonergic neurons in nonhuman primates. JAMA 1988;260: 51-55.
    • (1988) JAMA , vol.260 , pp. 51-55
    • Ricaurte, G.A.1    Forno, L.S.2    Wilson, M.A.3    DeLanney, L.E.4    Irwin, I.5    Molliver, M.E.6
  • 7
    • 0023811368 scopus 로고
    • Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA)
    • Slikker W, Ali SF, Scallet C, Frith CH, Newport GD, Bailey JR: Neurochemical and neurohistological alterations in the rat and monkey produced by orally administered methylenedioxymethamphetamine (MDMA). Toxicol Appl Pharmacol 1988;94:448-457.
    • (1988) Toxicol Appl Pharmacol , vol.94 , pp. 448-457
    • Slikker, W.1    Ali, S.F.2    Scallet, C.3    Frith, C.H.4    Newport, G.D.5    Bailey, J.R.6
  • 8
    • 0024383159 scopus 로고
    • 3,4-Methylenedioxymethamphetamine ('ecstasy') selectively destroys brain serotonin terminals in rhesus monkeys
    • Insel RT, Battaglia G, Johannessen JN, Marra S, De Souza EB: 3,4-Methylenedioxymethamphetamine ('ecstasy') selectively destroys brain serotonin terminals in rhesus monkeys. J Pharmacol Exp Ther 1989;249:713-720.
    • (1989) J Pharmacol Exp Ther , vol.249 , pp. 713-720
    • Insel, R.T.1    Battaglia, G.2    Johannessen, J.N.3    Marra, S.4    De Souza, E.B.5
  • 11
    • 0032161183 scopus 로고    scopus 로고
    • The role of dopaminergic systems in the perinatal sensitivity to 3,4-methylenedioxymethamphetamine-induced neurotoxicity in rats
    • Aguirre N, Barrionuevo M, Lasheras B, DelRio J: The role of dopaminergic systems in the perinatal sensitivity to 3,4-methylenedioxymethamphetamine-induced neurotoxicity in rats. J Pharmacol Exp Ther 1998;286:1159-1165.
    • (1998) J Pharmacol Exp Ther , vol.286 , pp. 1159-1165
    • Aguirre, N.1    Barrionuevo, M.2    Lasheras, B.3    DelRio, J.4
  • 12
    • 0033550642 scopus 로고    scopus 로고
    • Positron emission tomography findings in heavy users of MDMA
    • Holland J: Positron emission tomography findings in heavy users of MDMA. Lancet 1999; 353:592-593.
    • (1999) Lancet , vol.353 , pp. 592-593
    • Holland, J.1
  • 13
    • 0024159060 scopus 로고
    • MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons
    • Battaglia G, Yeh SY, De Souza EB: MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons. Pharmacol Biochem Behav 1988;29:269-274.
    • (1988) Pharmacol Biochem Behav , vol.29 , pp. 269-274
    • Battaglia, G.1    Yeh, S.Y.2    De Souza, E.B.3
  • 14
    • 0026612759 scopus 로고
    • Lasting of (±)3,4-methylenedioxymethamphetamine on central serotonergic neurons in non-human primates: Neurochemical observations
    • Ricaurte GA, Martello AL, Katz JL, Martello MB: Lasting of (±)3,4-methylenedioxymethamphetamine on central serotonergic neurons in non-human primates: Neurochemical observations. J Pharmacol Exp Ther 1992;261:616-622.
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 616-622
    • Ricaurte, G.A.1    Martello, A.L.2    Katz, J.L.3    Martello, M.B.4
  • 16
    • 0029125154 scopus 로고
    • Reorganization of ascending serotonin axon projections in animals previously exposed to the recreational drug 3,4-methylenedioxymethamphetamine
    • Fischer CA, Hatzidimitriou G, Katz JL, Ricaurte GA: Reorganization of ascending serotonin axon projections in animals previously exposed to the recreational drug 3,4-methylenedioxymethamphetamine. J Neurosci 1995; 15:5476-5485.
    • (1995) J Neurosci , vol.15 , pp. 5476-5485
    • Fischer, C.A.1    Hatzidimitriou, G.2    Katz, J.L.3    Ricaurte, G.A.4
  • 17
    • 0030087725 scopus 로고    scopus 로고
    • Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. II. Radioligand binding and autoradiography studies
    • Lew R, Sabol KE, Chou C, Vosmer GL, Richards J, Seiden LS: Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. II. Radioligand binding and autoradiography studies. J Pharmacol Exp Ther 1996;276: 855-865.
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 855-865
    • Lew, R.1    Sabol, K.E.2    Chou, C.3    Vosmer, G.L.4    Richards, J.5    Seiden, L.S.6
  • 18
    • 0030087890 scopus 로고    scopus 로고
    • Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Synaptosomal uptake and tissue concentrations
    • Sabol KE, Lew R, Richards JB, Vosmer GL, Seiden LS: Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Synaptosomal uptake and tissue concentrations. J Pharmacol Exp Ther 1996;276:846-854.
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 846-854
    • Sabol, K.E.1    Lew, R.2    Richards, J.B.3    Vosmer, G.L.4    Seiden, L.S.5
  • 19
    • 0033564773 scopus 로고    scopus 로고
    • Altered serotonin innervation patterns in the forebrain of monkeys treated with (±)3,4-methylenedioxymethamphetamine seven years previously: Factors influencing abnormal recovery
    • Hatzidimitriou G, McCann UD, Ricaurte GA: Altered serotonin innervation patterns in the forebrain of monkeys treated with (±)3,4-methylenedioxymethamphetamine seven years previously: Factors influencing abnormal recovery. J Neurosci 1999;191:5096-5107.
    • (1999) J Neurosci , vol.191 , pp. 5096-5107
    • Hatzidimitriou, G.1    McCann, U.D.2    Ricaurte, G.A.3
  • 21
    • 0023475168 scopus 로고
    • Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine
    • Schmidt CJ, Taylor VL: Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine. Biochem Pharmacol 1987;36:4095-4102.
    • (1987) Biochem Pharmacol , vol.36 , pp. 4095-4102
    • Schmidt, C.J.1    Taylor, V.L.2
  • 22
    • 0023735752 scopus 로고
    • Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: Immunocytochemical evidence for neurotoxicity
    • O'Hearn EG, Battaglia G, De Souza EB, Kuhar MJ, Molliver ME: Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: Immunocytochemical evidence for neurotoxicity. J Neurosci 1988;8:2788-2803.
    • (1988) J Neurosci , vol.8 , pp. 2788-2803
    • O'Hearn, E.G.1    Battaglia, G.2    De Souza, E.B.3    Kuhar, M.J.4    Molliver, M.E.5
  • 24
    • 0024541227 scopus 로고
    • Distinct morphologic classes of serotonergic axons in primates exhibit differential vulnerability to the psychotropic drug 3,4-methylenedioxymethamphetamine
    • Wilson MA, Ricaurte GA, Molliver ME: Distinct morphologic classes of serotonergic axons in primates exhibit differential vulnerability to the psychotropic drug 3,4-methylenedioxymethamphetamine. Neuroscience 1989;28: 121-137.
    • (1989) Neuroscience , vol.28 , pp. 121-137
    • Wilson, M.A.1    Ricaurte, G.A.2    Molliver, M.E.3
  • 27
    • 0000301321 scopus 로고    scopus 로고
    • Long-lasting effects of recreational drugs of abuse on the central nervous system
    • McCann UD, Lowe KA, Ricaurte GA: Long-lasting effects of recreational drugs of abuse on the central nervous system. Neuroscientist 1997;3:399-411.
    • (1997) Neuroscientist , vol.3 , pp. 399-411
    • McCann, U.D.1    Lowe, K.A.2    Ricaurte, G.A.3
  • 28
    • 0028291402 scopus 로고
    • Short-term treatments with haloperidol or bromocryptine do not alter the density of the vesicular monoamine transporter
    • Naudon L, Leroux-Nicollet I, Constentin J: Short-term treatments with haloperidol or bromocryptine do not alter the density of the vesicular monoamine transporter. Neurosci Lett 1994;173:1-4.
    • (1994) Neurosci Lett , vol.173 , pp. 1-4
    • Naudon, L.1    Leroux-Nicollet, I.2    Constentin, J.3
  • 29
    • 0029558914 scopus 로고
    • The vesicular monoamine transporter is not regulated by dopaminergic drug treatments
    • Vander Borght T, Sima A, Kilbourn MR, et al: The vesicular monoamine transporter is not regulated by dopaminergic drug treatments. Eur J Pharmacol 1995;294:577-583.
    • (1995) Eur J Pharmacol , vol.294 , pp. 577-583
    • Vander Borght, T.1    Sima, A.2    Kilbourn, M.R.3
  • 30
    • 0030846635 scopus 로고    scopus 로고
    • Reduced striatal vesicular monoamine transporter after neurotoxic but not after behaviourally-sensitizing doses of methamphetamine
    • Frey K, Kilbourne M, Robinson T: Reduced striatal vesicular monoamine transporter after neurotoxic but not after behaviourally-sensitizing doses of methamphetamine. Eur J Pharmacol 1997;334:273-279.
    • (1997) Eur J Pharmacol , vol.334 , pp. 273-279
    • Frey, K.1    Kilbourne, M.2    Robinson, T.3
  • 32
    • 0017072557 scopus 로고
    • Axonal transport in serotonin neurons of the midbrain raphe
    • Halaris A, Jones B, Moore R: Axonal transport in serotonin neurons of the midbrain raphe. Brain Res 1976;107:555-574.
    • (1976) Brain Res , vol.107 , pp. 555-574
    • Halaris, A.1    Jones, B.2    Moore, R.3
  • 33
    • 0004422873 scopus 로고    scopus 로고
    • Long-term effects of substituted amphetamines on anterograde axonal transport from the rostral raphe nuclei
    • Callahan BT, Hatzidimitriou G, Yuan J, Ricaurte GA: Long-term effects of substituted amphetamines on anterograde axonal transport from the rostral raphe nuclei. Soc Neurosci Abstr 1998;24:1735.
    • (1998) Soc Neurosci Abstr , vol.24 , pp. 1735
    • Callahan, B.T.1    Hatzidimitriou, G.2    Yuan, J.3    Ricaurte, G.A.4
  • 34
    • 0018198148 scopus 로고
    • Development plasticity of central serotonin neurons after 5,7-dihydroxytryptamine treatment
    • Jonsson G, Pollare T, Hallman H, Sachs C: Development plasticity of central serotonin neurons after 5,7-dihydroxytryptamine treatment. Ann NY Acad Sci 1978;305:328-345.
    • (1978) Ann NY Acad Sci , vol.305 , pp. 328-345
    • Jonsson, G.1    Pollare, T.2    Hallman, H.3    Sachs, C.4
  • 35
    • 0015765706 scopus 로고
    • Early lesions of the superior colliculus: Factors affecting the formation of abnormal retinal projections
    • Schneider GF: Early lesions of the superior colliculus: Factors affecting the formation of abnormal retinal projections. Brain Behav Evol 1973;8:73-109.
    • (1973) Brain Behav Evol , vol.8 , pp. 73-109
    • Schneider, G.F.1
  • 36
    • 0018912798 scopus 로고
    • Organization of brainstem noradrenaline hyperinnervation following neonatal 6-hydroxydopamine treatment in the rat
    • Levitt P, Moore R: Organization of brainstem noradrenaline hyperinnervation following neonatal 6-hydroxydopamine treatment in the rat. Anal Embryol 1980;158:133-150.
    • (1980) Anal Embryol , vol.158 , pp. 133-150
    • Levitt, P.1    Moore, R.2
  • 37
    • 0020354032 scopus 로고
    • Changes in the development of central noradrenergic neurons after neonatal axon lesions
    • Jonsson G, Sachs C: Changes in the development of central noradrenergic neurons after neonatal axon lesions. Brain Res Bull 1982;9: 641-650.
    • (1982) Brain Res Bull , vol.9 , pp. 641-650
    • Jonsson, G.1    Sachs, C.2
  • 38
    • 0023514289 scopus 로고
    • Noradrenaline neuron plasticity in developing rat brain: Effects of neonatal 6-hydroxydopamine demonstrated by dopamine-B-hydroxylase immunocytochemistry
    • Gustafson E, Moore R: Noradrenaline neuron plasticity in developing rat brain: Effects of neonatal 6-hydroxydopamine demonstrated by dopamine-B-hydroxylase immunocytochemistry. Dev Brain Res 1987;37:143-155.
    • (1987) Dev Brain Res , vol.37 , pp. 143-155
    • Gustafson, E.1    Moore, R.2
  • 39
    • 0026729733 scopus 로고
    • Restoration of ascending noradrenergic projections by residual locus coeruleus neurons: Compensatory response to neurotoxin-induced cell death in the adult rat brain
    • Fritschy J, Grzanna R: Restoration of ascending noradrenergic projections by residual locus coeruleus neurons: Compensatory response to neurotoxin-induced cell death in the adult rat brain. J Comp Neurol 1992;321:421-441.
    • (1992) J Comp Neurol , vol.321 , pp. 421-441
    • Fritschy, J.1    Grzanna, R.2
  • 40
    • 0016722039 scopus 로고
    • 5,7-Dihydroxytryptamine induced changes in the postnatal development of central 5-hydroxytryptamine neurons
    • Sachs C, Jonsson G: 5,7-dihydroxytryptamine induced changes in the postnatal development of central 5-hydroxytryptamine neurons. Med Biol 1975;53:156-164.
    • (1975) Med Biol , vol.53 , pp. 156-164
    • Sachs, C.1    Jonsson, G.2
  • 41
    • 0018198134 scopus 로고
    • Regeneration of serotonin neurons in the rat brain after 5,6-dihydroxytryptamine-induced axotomy
    • Wiklund L, Bjorklund A, Nobin A: Regeneration of serotonin neurons in the rat brain after 5,6-dihydroxytryptamine-induced axotomy. Ann NY Acad Sci 1978;305:370-384.
    • (1978) Ann NY Acad Sci , vol.305 , pp. 370-384
    • Wiklund, L.1    Bjorklund, A.2    Nobin, A.3
  • 42
    • 0019501865 scopus 로고
    • Regeneration and plasticity of central serotonergic neurons: A review
    • Bjorklund A, Wiklund L, Descarries L: Regeneration and plasticity of central serotonergic neurons: A review. J Physiol 1979;77:247-255.
    • (1979) J Physiol , vol.77 , pp. 247-255
    • Bjorklund, A.1    Wiklund, L.2    Descarries, L.3
  • 43
    • 0021215540 scopus 로고
    • Regeneration of serotonergic fibers in the rat hypothalamus following unilateral 5,7-dihydroxytryptamine injection
    • Frankfurt M, Azmitia E: Regeneration of serotonergic fibers in the rat hypothalamus following unilateral 5,7-dihydroxytryptamine injection. Brain Res 1984;298:273-282.
    • (1984) Brain Res , vol.298 , pp. 273-282
    • Frankfurt, M.1    Azmitia, E.2
  • 44
    • 0023522125 scopus 로고
    • Differences in the central serotonergic effects of 3,4-methylenedioxymethamphetamine(MDMA) in mice and rats
    • Stone DM, Hanson GL, Gibb JW: Differences in the central serotonergic effects of 3,4-methylenedioxymethamphetamine(MDMA) in mice and rats. Neuropharmacology 1987;26:1657-1661.
    • (1987) Neuropharmacology , vol.26 , pp. 1657-1661
    • Stone, D.M.1    Hanson, G.L.2    Gibb, J.W.3
  • 45
    • 0023897261 scopus 로고
    • Orally administered MDMA causes a long-term depletion of serotonin in rat brain
    • Finnegan KT, Ricaurte GA, Ritchie CD, Irwin I, et al: Orally administered MDMA causes a long-term depletion of serotonin in rat brain. Brain Res 1988;447:141-144.
    • (1988) Brain Res , vol.447 , pp. 141-144
    • Finnegan, K.T.1    Ricaurte, G.A.2    Ritchie, C.D.3    Irwin, I.4
  • 46
    • 0023902232 scopus 로고
    • Toxic effects of MDMA on central serotonergic neurons in the primate: Importance of route and frequency of drug administration
    • Ricaurte GA, DcLanney LE, Irwin I, Langston JW: Toxic effects of MDMA on central serotonergic neurons in the primate: Importance of route and frequency of drug administration. Brain Res 1988;446:165-168.
    • (1988) Brain Res , vol.446 , pp. 165-168
    • Ricaurte, G.A.1    DcLanney, L.E.2    Irwin, I.3    Langston, J.W.4
  • 47
    • 0002209037 scopus 로고
    • The use of interspecies scaling in toxicokinetics
    • Yacobi A, Kelly J, Batral V (eds) New York, Pergamon Press
    • Mordenti J, Chappell W: The use of interspecies scaling in toxicokinetics: in Yacobi A, Kelly J, Batral V (eds): Toxicokinetics in New Drug Development. New York, Pergamon Press 1989, pp 42-96.
    • (1989) Toxicokinetics in New Drug Development , pp. 42-96
    • Mordenti, J.1    Chappell, W.2
  • 48
    • 0025767307 scopus 로고
    • Extrapolation of toxicological and pharmacological data from animals to humans
    • Testa B (ed) San Diego, Academic Press
    • Chappell W, Mordenti J: Extrapolation of toxicological and pharmacological data from animals to humans; in Testa B (ed): Advances in Drug Research. San Diego, Academic Press, 1991, vol 20, pp 1-116.
    • (1991) Advances in Drug Research , vol.20 , pp. 1-116
    • Chappell, W.1    Mordenti, J.2
  • 49
    • 0031879806 scopus 로고    scopus 로고
    • The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy')
    • O'Shea E, Granados R, Esteban B, Colado MI, Green AR: The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy'). Neuropharmacology 1998;37:919-926.
    • (1998) Neuropharmacology , vol.37 , pp. 919-926
    • O'Shea, E.1    Granados, R.2    Esteban, B.3    Colado, M.I.4    Green, A.R.5
  • 50
    • 0028292728 scopus 로고
    • 3,4-Methylenedioxymethamphetamine (MDMA, 'Ecstasy'): Pharmacology and toxicology in animals and humans
    • Steele T, McCann U, Ricaurte G: 3,4-Methylenedioxymethamphetamine (MDMA, 'Ecstasy'): Pharmacology and toxicology in animals and humans. Addiction 1994;89:539-551.
    • (1994) Addiction , vol.89 , pp. 539-551
    • Steele, T.1    McCann, U.2    Ricaurte, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.