메뉴 건너뛰기




Volumn 10, Issue 9, 2014, Pages 2261-2294

Vaccine technologies against avian influenza: Current approaches and new directions

Author keywords

Antiviral; H5N1; Highly pathogenic avian influenza; Pandemic; Vaccine

Indexed keywords

VIRUSES;

EID: 84904869711     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2014.1983     Document Type: Review
Times cited : (8)

References (336)
  • 2
    • 77952559017 scopus 로고    scopus 로고
    • Clinical analysis of 150 cases with the novel influenza A (H1N1) virus infection in Shanghai, China
    • Q. Ou, Y. Lu, Q. Huang, and X. Cheng, Clinical analysis of 150 cases with the novel influenza A (H1N1) virus infection in Shanghai, China. Biosci. Trends. 3, 127 (2009).
    • (2009) Biosci. Trends. , vol.3 , pp. 127
    • Ou, Q.1    Lu, Y.2    Huang, Q.3    Cheng, X.4
  • 5
    • 22944457912 scopus 로고    scopus 로고
    • Influenza: Lessons from past pandemics, warnings from current incidents
    • T. Horimoto and Y. Kawakoka, Influenza: Lessons from past pandemics, warnings from current incidents. Nat. Rev. Microbiol. 3, 591 (2005).
    • (2005) Nat. Rev. Microbiol. , vol.3 , pp. 591
    • Horimoto, T.1    Kawakoka, Y.2
  • 6
    • 27244434426 scopus 로고    scopus 로고
    • Replicative homeostasis II: Influence of polymerase fidelity on RNA virus quasispecies biology: Implications for immune recognition, viral autoimmunity and other "virus receptor" diseases
    • R. Sallie, Replicative homeostasis II: Influence of polymerase fidelity on RNA virus quasispecies biology: Implications for immune recognition, viral autoimmunity and other "virus receptor" diseases. Virol. J. 2, 70 (2005).
    • (2005) Virol. J. , vol.2 , pp. 70
    • Sallie, R.1
  • 7
    • 0034051550 scopus 로고    scopus 로고
    • Global epidemiology of influenza: Past and present
    • N. J. Cox and K. Subbarao, Global epidemiology of influenza: Past and present. Annu. Rev. Med. 51, 407 (2000).
    • (2000) Annu. Rev. Med. , vol.51 , pp. 407
    • Cox, N.J.1    Subbarao, K.2
  • 9
    • 33645278326 scopus 로고    scopus 로고
    • Avian flu: Influenza virus receptors in the human airway
    • K. Shinya, M. Ebina, S. Yamada, M. Ono, N. Kasai, and Y. Kawaoka, Avian flu: Influenza virus receptors in the human airway. Nature 440, 435 (2006).
    • (2006) Nature , vol.440 , pp. 435
    • Shinya, K.1    Ebina, M.2    Yamada, S.3    Ono, M.4    Kasai, N.5    Kawaoka, Y.6
  • 12
    • 67449136751 scopus 로고    scopus 로고
    • The pig as a mixing vessel for influenza viruses: Human and veterinary implications
    • W. Ma, R. E. Kahn, and J. A. Richt, The pig as a mixing vessel for influenza viruses: Human and veterinary implications. J. Mol. Genet. Med. 3, 158 (2009).
    • (2009) J. Mol. Genet. Med. , vol.3 , pp. 158
    • Ma, W.1    Kahn, R.E.2    Richt, J.A.3
  • 13
    • 79953280901 scopus 로고    scopus 로고
    • The contribution of animal models to the understanding of the host range and virulence of influenza A viruses
    • C. D. O'Donnell and K. Subbarao, The contribution of animal models to the understanding of the host range and virulence of influenza A viruses. Microbes Infect. 13, 502 (2011).
    • (2011) Microbes Infect. , vol.13 , pp. 502
    • O'Donnell, C.D.1    Subbarao, K.2
  • 18
    • 38349068756 scopus 로고    scopus 로고
    • Update on avian influenza A (H5N1) virus infection in humans
    • Writing Committee of the Second World Health Organization Consultation on Clinical Aspects of Human Infection with Avian Influenza A Virus
    • Writing Committee of the Second World Health Organization Consultation on Clinical Aspects of Human Infection with Avian Influenza A Virus: A. N. Abdel-Ghafar, T. Chotpitayasunondh, Z. Gao, F. G. Hayden, D. H. Nguyen, M. D. de Jong, A. Naghdaliyev, J. S. Peiris, N. Shindo, S. Soeroso, and T. M. Uyeki, Update on avian influenza A (H5N1) virus infection in humans. N. Engl. J. Med. 358, 261 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , pp. 261
    • Abdel-Ghafar, A.N.1    Chotpitayasunondh, T.2    Gao, Z.3    Hayden, F.G.4    Nguyen, D.H.5    De Jong, M.D.6    Naghdaliyev, A.7    Peiris, J.S.8    Shindo, N.9    Soeroso, S.10    Uyeki, T.M.11
  • 21
    • 43449131547 scopus 로고    scopus 로고
    • Pathology, molecular biology, and pathogenesis of avian influenza A (H5N1) infection in humans
    • C. Korteweg and J. Gu, Pathology, molecular biology, and pathogenesis of avian influenza A (H5N1) infection in humans. Am. J. Pathol. 172, 1155 (2008).
    • (2008) Am. J. Pathol. , vol.172 , pp. 1155
    • Korteweg, C.1    Gu, J.2
  • 24
    • 34248170234 scopus 로고    scopus 로고
    • Avian influenza virus (H5N1): A threat to human health
    • J. S. M. Peiris, M. D. de Jong, and Y. Guan, Avian influenza virus (H5N1): A threat to human health. Clin. Microbiol. Rev. 20, 243 (2007).
    • (2007) Clin. Microbiol. Rev. , vol.20 , pp. 243
    • Peiris, J.S.M.1    De Jong, M.D.2    Guan, Y.3
  • 25
    • 0037038866 scopus 로고    scopus 로고
    • Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: A mechanism for the unusual severity of human disease?
    • C. Y. Cheung, L. L. M. Poon, A. S. Lau, W. Luk, Y. L. Lau, K. F. Shortridge, S. Gordon, Y. Guan, and J. S. Peiris, Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: A mechanism for the unusual severity of human disease? Lancet 360, 1831 (2002).
    • (2002) Lancet , vol.360 , pp. 1831
    • Cheung, C.Y.1    Poon, L.L.M.2    Lau, A.S.3    Luk, W.4    Lau, Y.L.5    Shortridge, K.F.6    Gordon, S.7    Guan, Y.8    Peiris, J.S.9
  • 26
    • 0030986645 scopus 로고    scopus 로고
    • Susceptibility of mononuclear phagocytes to influenza A virus infection and possible role in the antiviral response
    • P. Hofmann, H. Sprenger, A. Kaufmann, A. Bender, C. Hasse, M. Nain, and D. Gemsa, Susceptibility of mononuclear phagocytes to influenza A virus infection and possible role in the antiviral response. J. Leukoc. Biol. 61, 408 (1997).
    • (1997) J. Leukoc. Biol. , vol.61 , pp. 408
    • Hofmann, P.1    Sprenger, H.2    Kaufmann, A.3    Bender, A.4    Hasse, C.5    Nain, M.6    Gemsa, D.7
  • 27
    • 0034633822 scopus 로고    scopus 로고
    • Influenza A and sendai viruses induce differential chemokine gene expression and transcription factor activation in human macrophages
    • S. Matikainen, J. Pirhonen, M. Miettinen, A. Lehtonen, C. Govenius-Vintola, T. Sareneva, and I. Julkunen, Influenza A and sendai viruses induce differential chemokine gene expression and transcription factor activation in human macrophages. Virology 276, 138 (2000).
    • (2000) Virology , vol.276 , pp. 138
    • Matikainen, S.1    Pirhonen, J.2    Miettinen, M.3    Lehtonen, A.4    Govenius-Vintola, C.5    Sareneva, T.6    Julkunen, I.7
  • 28
    • 77649299022 scopus 로고    scopus 로고
    • Influenza H5N1 and H1N1 virus replication and innate immune responses in bronchial epithelial cells are influenced by the state of differentiation
    • R. W. Y. Chan, K. M. Yuen, W. C. L. Yu, C. C. C. Ho, J. M. Nicholls, J. S. M. Peiris, and M. C. W. Chan, Influenza H5N1 and H1N1 virus replication and innate immune responses in bronchial epithelial cells are influenced by the state of differentiation. PLoS ONE 5, e8713 (2010).
    • (2010) PLoS ONE , vol.5
    • Chan, R.W.Y.1    Yuen, K.M.2    Yu, W.C.L.3    Ho, C.C.C.4    Nicholls, J.M.5    Peiris, J.S.M.6    Chan, M.C.W.7
  • 30
    • 34547619982 scopus 로고    scopus 로고
    • Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection
    • R. Salomon, E. Hoffmann, and R. G. Webster, Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection. PNAS 104, 12479 (2007).
    • (2007) PNAS , vol.104 , pp. 12479
    • Salomon, R.1    Hoffmann, E.2    Webster, R.G.3
  • 31
    • 77950479967 scopus 로고    scopus 로고
    • Macrophage receptors for influenza A virus: Role of the macrophage galactose-type lectin and mannose receptor in viral entry
    • J. P. Upham, D. Picktett, T. Irimura, E. M. Anders, and P. C. Reading, Macrophage receptors for influenza A virus: Role of the macrophage galactose-type lectin and mannose receptor in viral entry. J. Virol. 84, 3730 (2010).
    • (2010) J. Virol. , vol.84 , pp. 3730
    • Upham, J.P.1    Picktett, D.2    Irimura, T.3    Anders, E.M.4    Reading, P.C.5
  • 32
    • 77951087220 scopus 로고    scopus 로고
    • CCL20/CCR6 blockade enhances immunity to respiratory syncytial virus by impairing recruitment of dendritic cells
    • L. E. Kallal, M. A. Schaller, D. M. Lindell, S. A. Lira, and N. W. Lukacs, CCL20/CCR6 blockade enhances immunity to respiratory syncytial virus by impairing recruitment of dendritic cells. Eur. J. Immunol. 40, 1042 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , pp. 1042
    • Kallal, L.E.1    Schaller, M.A.2    Lindell, D.M.3    Lira, S.A.4    Lukacs, N.W.5
  • 34
    • 0442323299 scopus 로고    scopus 로고
    • Influenza virus: Immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines
    • R. J. Cox, K. A. Brokstad, and P. Ogra, Influenza virus: Immunity and vaccination strategies. comparison of the immune response to inactivated and live, attenuated influenza vaccines. Scand. J. Immunol. 59, 1 (2004).
    • (2004) Scand. J. Immunol. , vol.59 , pp. 1
    • Cox, R.J.1    Brokstad, K.A.2    Ogra, P.3
  • 36
    • 77951825335 scopus 로고    scopus 로고
    • Recipients of vaccine against the 1976 "swine flu" have enhanced neutralization responses to the 2009 novel H1N1 influenza virus
    • J. A. McCullers, L-A Van De Velde, K. J. Allison, K. C. Branum, R. J. Webby, and P. M. Flynn, Recipients of vaccine against the 1976 "swine flu" have enhanced neutralization responses to the 2009 novel H1N1 influenza virus. Clin. Infect. Dis. 50, 1487 (2010).
    • (2010) Clin. Infect. Dis. , vol.50 , pp. 1487
    • McCullers, J.A.1    Van De Velde, L.-A.2    Allison, K.J.3    Branum, K.C.4    Webby, R.J.5    Flynn, P.M.6
  • 38
    • 0030035675 scopus 로고    scopus 로고
    • Side effects associated with influenza vaccination in healthy working adults: A randomized, placebo-controlled trial
    • K. L. Nichol, K. L. Margolis, A. Lind, M. Murdoch, R. McFadden, M. Hauge, S. Magnan, and M. Drake, Side effects associated with influenza vaccination in healthy working adults: A randomized, placebo-controlled trial. Arch. Intern. Med. 156, 1546 (1996).
    • (1996) Arch. Intern. Med. , vol.156 , pp. 1546
    • Nichol, K.L.1    Margolis, K.L.2    Lind, A.3    Murdoch, M.4    McFadden, R.5    Hauge, M.6    Magnan, S.7    Drake, M.8
  • 39
    • 0025113380 scopus 로고
    • Frequency of adverse reactions to influenza vaccine in the elderly
    • K. L. Margolis, K. L. Nichol, G. A. Poland, and R. E. Pluhar, Frequency of adverse reactions to influenza vaccine in the elderly. JAMA 264, 1139 (1990).
    • (1990) JAMA , vol.264 , pp. 1139
    • Margolis, K.L.1    Nichol, K.L.2    Poland, G.A.3    Pluhar, R.E.4
  • 40
    • 0031930630 scopus 로고    scopus 로고
    • Comparison of serology and reactogenicity between influenza subunit vaccines and whole virus or split vaccines: A review and meta-analysis of the literature
    • W. Beyer, A. Palache, and A. Osterhaus, Comparison of serology and reactogenicity between influenza subunit vaccines and whole virus or split vaccines: A review and meta-analysis of the literature. Clin. Drug Invest. 15, 1 (1998).
    • (1998) Clin. Drug Invest. , vol.15 , pp. 1
    • Beyer, W.1    Palache, A.2    Osterhaus, A.3
  • 42
    • 27744475145 scopus 로고    scopus 로고
    • Influenza pandemics and avian flu
    • D. Fleming, Influenza pandemics and avian flu. BMJ 331, 1066 (2005).
    • (2005) BMJ , vol.331 , pp. 1066
    • Fleming, D.1
  • 43
    • 4844227626 scopus 로고    scopus 로고
    • From lethal virus to live-saving vaccine: Developing inactivated vaccines for pandemic influenza
    • J. M. Wood and J. S. Robertson, From lethal virus to live-saving vaccine: Developing inactivated vaccines for pandemic influenza. Nat. Rev. Microbiol. 2, 842 (2004).
    • (2004) Nat. Rev. Microbiol. , vol.2 , pp. 842
    • Wood, J.M.1    Robertson, J.S.2
  • 44
    • 33846392908 scopus 로고    scopus 로고
    • The humoral and cellular responses induced locally and systemically after parenteral influenza vaccination in man
    • R. J. Cox, L. R. Haaheim, J-C Ericsson, A. S. Madhun, and K. A. Brokstad, The humoral and cellular responses induced locally and systemically after parenteral influenza vaccination in man. Vaccine 25, 6577 (2006).
    • (2006) Vaccine , vol.25 , pp. 6577
    • Cox, R.J.1    Haaheim, L.R.2    Ericsson, J.-C.3    Madhun, A.S.4    Brokstad, K.A.5
  • 45
    • 0028817217 scopus 로고
    • Parenteral influenza vaccination induces a rapid systemic and local immune response
    • K. A. Brokstad, R. J. Cox, J. Olofsson, R. Jonsson, and L. R. Haaheim, Parenteral influenza vaccination induces a rapid systemic and local immune response. J. Infect. Dis. 171, 198 (1995).
    • (1995) J. Infect. Dis. , vol.171 , pp. 198
    • Brokstad, K.A.1    Cox, R.J.2    Olofsson, J.3    Jonsson, R.4    Haaheim, L.R.5
  • 46
    • 0033380434 scopus 로고    scopus 로고
    • The effect of age and natural priming on the IgG and IgA subclass responses after parenteral influenza vaccination
    • S. Abdullah, R. J. C. El-Madhun, and L. R. Haaheim, The effect of age and natural priming on the IgG and IgA subclass responses after parenteral influenza vaccination. J. Infect. Dis. 180, 1356 (1999).
    • (1999) J. Infect. Dis. , vol.180 , pp. 1356
    • Abdullah, S.1    El-Madhun, R.J.C.2    Haaheim, L.R.3
  • 47
    • 0035860614 scopus 로고    scopus 로고
    • The effect of zanamivir treatment on the early immune response to influenza vaccination
    • R. J. Cox, E. Mykkeltvedt, H. Sjursen, and L. R. Haaheim, The effect of zanamivir treatment on the early immune response to influenza vaccination. Vaccine 19, 4743 (2001).
    • (2001) Vaccine , vol.19 , pp. 4743
    • Cox, R.J.1    Mykkeltvedt, E.2    Sjursen, H.3    Haaheim, L.R.4
  • 48
    • 9444276054 scopus 로고    scopus 로고
    • Parenteral influenza vaccination influences mucosal and systemic T cell-mediated immunity in healthy adults
    • T. Guthrie, C. G. Hobbs, V. Davenport, R. E. Horton, R. S. Heyderman, and N. A. Williams, Parenteral influenza vaccination influences mucosal and systemic T cell-mediated immunity in healthy adults. J. Infect. Dis. 190, 1927 (2004).
    • (2004) J. Infect. Dis. , vol.190 , pp. 1927
    • Guthrie, T.1    Hobbs, C.G.2    Davenport, V.3    Horton, R.E.4    Heyderman, R.S.5    Williams, N.A.6
  • 49
    • 0141786276 scopus 로고    scopus 로고
    • Influenza vaccination is less effective for stimulating a Granzyme B response in older adults
    • C. R. Letter, S. Gravenstein, and J. E. McElhaney, Influenza vaccination is less effective for stimulating a Granzyme B response in older adults. International Congress Series 1219, 713 (2001).
    • (2001) International Congress Series , vol.1219 , pp. 713
    • Letter, C.R.1    Gravenstein, S.2    McElhaney, J.E.3
  • 50
    • 17144419296 scopus 로고    scopus 로고
    • Comparison of single versus booster dose of influenza vaccination on humoral and cellular immune responses in older adults
    • J. E. McElhaney, J. W. Hooton, N. Hooton, and R. C. Bleackley, Comparison of single versus booster dose of influenza vaccination on humoral and cellular immune responses in older adults. Vaccine 23, 3294 (2005).
    • (2005) Vaccine , vol.23 , pp. 3294
    • McElhaney, J.E.1    Hooton, J.W.2    Hooton, N.3    Bleackley, R.C.4
  • 51
    • 33645399959 scopus 로고    scopus 로고
    • Safety and immunogenicity of an inactivated subvirion influenza A (H5N1) vaccine
    • J. J. Treanor, J. D. Campbell, K. M. Zangwill, T. Rowe, and M. Wolff, Safety and immunogenicity of an inactivated subvirion influenza A (H5N1) vaccine. N. Engl. J. Med. 354, 1343 (2006).
    • (2006) N. Engl. J. Med. , vol.354 , pp. 1343
    • Treanor, J.J.1    Campbell, J.D.2    Zangwill, K.M.3    Rowe, T.4    Wolff, M.5
  • 52
    • 67650665332 scopus 로고    scopus 로고
    • Randomized, double blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older
    • A. R. Falsey, J. J. Treanor, N. Tornieporth, J. Capellan, and G. J. Gorse, Randomized, double blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older. J. Infect. Dis. 200, 172 (2009).
    • (2009) J. Infect. Dis. , vol.200 , pp. 172
    • Falsey, A.R.1    Treanor, J.J.2    Tornieporth, N.3    Capellan, J.4    Gorse, G.J.5
  • 54
    • 33646549355 scopus 로고    scopus 로고
    • Safety and immunogenicity of an inactivated split-virion influenza A/Vietnam/1194/ 2004 (H5N1) vaccine: Phase I randomised trial
    • J.-L. Bresson, C. Perronne, O. Launay, C. Gerdil, M. Saville, J. Wood, K. Hoschler, and M. C. Zambon, Safety and immunogenicity of an inactivated split-virion influenza A/Vietnam/1194/ 2004 (H5N1) vaccine: Phase I randomised trial. Lancet 367, 1657 (2006).
    • (2006) Lancet , vol.367 , pp. 1657
    • Bresson, J.-L.1    Perronne, C.2    Launay, O.3    Gerdil, C.4    Saville, M.5    Wood, J.6    Hoschler, K.7    Zambon, M.C.8
  • 57
    • 70350573451 scopus 로고    scopus 로고
    • Safety and immunogenicity of inactivated, Vero cell culture-derived whole virus influenza A/H5N1 vaccine given alone or with aluminum hydroxide adjuvant in healthy adults
    • W. A. Keitel, C. L. Dekker, C. Mink, J. D. Campbell, K. M. Edwards, .S. M. Patel, D. Y. Ho, H. K. Talbot, K. Guo, D. L. Noah, and H. Hill, Safety and immunogenicity of inactivated, Vero cell culture-derived whole virus influenza A/H5N1 vaccine given alone or with aluminum hydroxide adjuvant in healthy adults. Vaccine 27, 6642 (2009).
    • (2009) Vaccine , vol.27 , pp. 6642
    • Keitel, W.A.1    Dekker, C.L.2    Mink, C.3    Campbell, J.D.4    Edwards, K.M.5    Patel, S.M.6    Ho, D.Y.7    Talbot, H.K.8    Guo, K.9    Noah, D.L.10    Hill, H.11
  • 59
    • 84904861945 scopus 로고
    • Reviews in medical virology
    • T. A. Larson and L. A. Potter, Reviews in medical virology. JAMA 271, 73 (1994).
    • (1994) JAMA , vol.271 , pp. 73
    • Larson, T.A.1    Potter, L.A.2
  • 64
    • 84863229371 scopus 로고    scopus 로고
    • Protective efficacy of an H1N1 cold-adapted live vaccine against the 2009 pandemic H1N1, seasonal H1N1, and H5N1 influenza viruses in mice
    • J. Shi, Z. Wen, J. Guo, Y. Zhang, G. Deng, Y. Shu, D. Wang, Y. Jiang, Y. Kawaoka, Z. Bu, and H. Chen, Protective efficacy of an H1N1 cold-adapted live vaccine against the 2009 pandemic H1N1, seasonal H1N1, and H5N1 influenza viruses in mice. Antivir. Res. 93, 346 (2012).
    • (2012) Antivir. Res. , vol.93 , pp. 346
    • Shi, J.1    Wen, Z.2    Guo, J.3    Zhang, Y.4    Deng, G.5    Shu, Y.6    Wang, D.7    Jiang, Y.8    Kawaoka, Y.9    Bu, Z.10    Chen, H.11
  • 65
    • 84861302929 scopus 로고    scopus 로고
    • Cold-adapted pandemic 2009 H1N1 influenza virus live vaccine elicits cross-reactive immune responses against seasonal and H5 influenza A viruses
    • Y. H. Jang, Y. H. Byun, Y. J. Lee, Y. H. Lee, K.-H. Lee, and B. L. Seong, Cold-adapted pandemic 2009 H1N1 influenza virus live vaccine elicits cross-reactive immune responses against seasonal and H5 influenza A viruses. J. Virol. 86, 5953 (2012).
    • (2012) J. Virol. , vol.86 , pp. 5953
    • Jang, Y.H.1    Byun, Y.H.2    Lee, Y.J.3    Lee, Y.H.4    Lee, K.-H.5    Seong, B.L.6
  • 68
    • 34247365482 scopus 로고    scopus 로고
    • Efficacy of trivalent, cold-adapted, influenza virus vaccine against influenza A (Fujian), a drift variant, during 2003-2004
    • M. E. Halloran, P. A. Piedra, J. I. M. Longini, M. J. Gaglani, B. Schmotzer, C. Fewlass, G. B. Herschler, and W. P. Glezen, Efficacy of trivalent, cold-adapted, influenza virus vaccine against influenza A (Fujian), a drift variant, during 2003-2004. Vaccine 25, 4038 (2007).
    • (2007) Vaccine , vol.25 , pp. 4038
    • Halloran, M.E.1    Piedra, P.A.2    Longini, J.I.M.3    Gaglani, M.J.4    Schmotzer, B.5    Fewlass, C.6    Herschler, G.B.7    Glezen, W.P.8
  • 69
    • 77950236839 scopus 로고    scopus 로고
    • Influenza pathogenesis: Lessons learned from animal studies with H5N1, H1N1 Spanish, and pandemic H1N1 2009 influenza
    • I. Meunier, S. Pillet, J. N. Simonsen, and V. von Messling, Influenza pathogenesis: Lessons learned from animal studies with H5N1, H1N1 Spanish, and pandemic H1N1 2009 influenza. Crit. Care Med. 38, e21 (2010).
    • (2010) Crit. Care Med. , vol.38
    • Meunier, I.1    Pillet, S.2    Simonsen, J.N.3    Von Messling, V.4
  • 71
    • 0034051550 scopus 로고    scopus 로고
    • Global epidemiology of influenza: Past and present
    • N. J. Cox and K. Subbarao, Global epidemiology of influenza: Past and present. Annu. Rev. Med. 51, 407 (2000).
    • (2000) Annu. Rev. Med. , vol.51 , pp. 407
    • Cox, N.J.1    Subbarao, K.2
  • 72
    • 0034801450 scopus 로고    scopus 로고
    • Comparison of efficacies of RWJ-270201, zanamivir, and oseltamivir against H5N1, H9N2, and other avian influenza viruses
    • E. A. Govorkova, I. A. Leneva, O. G. Goloubeva, K. Bush, and R. G. Webster, Comparison of efficacies of RWJ-270201, zanamivir, and oseltamivir against H5N1, H9N2, and other avian influenza viruses. Antimicrob. Agents Chemother. 45, 2723 (2001).
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 2723
    • Govorkova, E.A.1    Leneva, I.A.2    Goloubeva, O.G.3    Bush, K.4    Webster, R.G.5
  • 76
    • 0035077692 scopus 로고    scopus 로고
    • Efficacy of zanamivir against avian influenza A viruses that possess genes encoding H5N1 internal proteins and are pathogenic in mammals
    • I. A. Leneva, O. Goloubeva, R. J. Fenton, M. Tisdale, and R. G. Webster, Efficacy of zanamivir against avian influenza A viruses that possess genes encoding H5N1 internal proteins and are pathogenic in mammals. Antimicrob. Agents Chemother. 45, 1216 (2001).
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 1216
    • Leneva, I.A.1    Goloubeva, O.2    Fenton, R.J.3    Tisdale, M.4    Webster, R.G.5
  • 78
    • 0022157043 scopus 로고
    • The molecular basis of the specific anti-influenza action of amantadine
    • A. J. Hay, A. J. Wolstenholme, J. J. Skehel, and M. H. Smith, The molecular basis of the specific anti-influenza action of amantadine. EMBO J. 4, 3021 (1985).
    • (1985) EMBO J. , vol.4 , pp. 3021
    • Hay, A.J.1    Wolstenholme, A.J.2    Skehel, J.J.3    Smith, M.H.4
  • 79
    • 37449007681 scopus 로고    scopus 로고
    • Amantadineresistance among H5N1 avian influenza viruses isolated in Northern China
    • G. He, J. Qiao, C. Dong, C. He, L. Zhao, and Y. Tian, Amantadineresistance among H5N1 avian influenza viruses isolated in Northern China. Antivir. Res. 77, 72 (2008).
    • (2008) Antivir. Res. , vol.77 , pp. 72
    • He, G.1    Qiao, J.2    Dong, C.3    He, C.4    Zhao, L.5    Tian, Y.6
  • 81
    • 65249091364 scopus 로고    scopus 로고
    • Poly(ortho ester amides): Acid-labile temperature-responsive copolymers for potential biomedical applications
    • R. Tang, R. N. Palumbo, W. Ji, and C. Wang, Poly(ortho ester amides): Acid-labile temperature-responsive copolymers for potential biomedical applications. Biomacromolecules 10, 722 (2009).
    • (2009) Biomacromolecules , vol.10 , pp. 722
    • Tang, R.1    Palumbo, R.N.2    Ji, W.3    Wang, C.4
  • 82
    • 63149194226 scopus 로고    scopus 로고
    • Pathogenesis of 1918 pandemic and H5N1 influenza virus infections in a guinea pig model: Antiviral potential of exogenous alpha interferon to reduce virus shedding
    • N. Van Hoeven, J. A. Belser, K. J. Szretter, H. Zeng, P. Staeheli, D. E. Swayne, J. M. Katz, and T. M. Tumpey, Pathogenesis of 1918 pandemic and H5N1 influenza virus infections in a guinea pig model: Antiviral potential of exogenous alpha interferon to reduce virus shedding. J. Virol. 83, 2851 (2009).
    • (2009) J. Virol. , vol.83 , pp. 2851
    • Van Hoeven, N.1    Belser, J.A.2    Szretter, K.J.3    Zeng, H.4    Staeheli, P.5    Swayne, D.E.6    Katz, J.M.7    Tumpey, T.M.8
  • 84
    • 34547619982 scopus 로고    scopus 로고
    • Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection
    • R. Salomon, E. Hoffmann, and R. G. Webster, Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection. PNAS 104, 12479 (2007).
    • (2007) PNAS , vol.104 , pp. 12479
    • Salomon, R.1    Hoffmann, E.2    Webster, R.G.3
  • 85
    • 35848929321 scopus 로고    scopus 로고
    • The threat of avian influenza A (H5N1). Part III: Antiviral therapy
    • J. Cinatl, M. Michaelis, and H. W. Doerr, The threat of avian influenza A (H5N1). Part III: Antiviral therapy. Med. Microbiol. Immun. 196, 203 (2007).
    • (2007) Med. Microbiol. Immun. , vol.196 , pp. 203
    • Cinatl, J.1    Michaelis, M.2    Doerr, H.W.3
  • 86
    • 43349090563 scopus 로고    scopus 로고
    • Influenza A/H5N1 infection: Other treatment options and issues
    • D. S. C. Hui, Influenza A/H5N1 infection: Other treatment options and issues. Respirology 13, S22 (2008).
    • (2008) Respirology , vol.13
    • Hui, D.S.C.1
  • 87
    • 67650217954 scopus 로고    scopus 로고
    • What is the optimal therapy for patients with H5N1 influenza?
    • N. J. White, R. G. Webster, E. A. Govorkova, and T. M. Uyeki, What is the optimal therapy for patients with H5N1 influenza? PLoS Med. 6, e1000091 (2009).
    • (2009) PLoS Med. , vol.6
    • White, N.J.1    Webster, R.G.2    Govorkova, E.A.3    Uyeki, T.M.4
  • 88
    • 52049100400 scopus 로고    scopus 로고
    • Stockpiling prepandemic influenza vaccines: A new cornerstone of pandemic preparedness plans
    • L. C. Jennings, A. S. Monto, P. K. Chan, T. D. Szucs, and K. G. Nicholson, Stockpiling prepandemic influenza vaccines: A new cornerstone of pandemic preparedness plans. Lancet Infect. Dis. 8, 650 (2008).
    • (2008) Lancet Infect. Dis. , vol.8 , pp. 650
    • Jennings, L.C.1    Monto, A.S.2    Chan, P.K.3    Szucs, T.D.4    Nicholson, K.G.5
  • 91
    • 0037402228 scopus 로고    scopus 로고
    • The annual production cycle for influenza vaccine
    • C. Gerdil, The annual production cycle for influenza vaccine. Vaccine 21, 1776 (2003).
    • (2003) Vaccine , vol.21 , pp. 1776
    • Gerdil, C.1
  • 92
    • 0034705225 scopus 로고    scopus 로고
    • A DNA transfection system for generation of influenza A virus from eight plasmids
    • E. Hoffmann, G. Neumann, Y. Kawaoka, G. Hobom, and R. G. Webster, A DNA transfection system for generation of influenza A virus from eight plasmids. PNAS 97, 6108 (2000).
    • (2000) PNAS , vol.97 , pp. 6108
    • Hoffmann, E.1    Neumann, G.2    Kawaoka, Y.3    Hobom, G.4    Webster, R.G.5
  • 94
    • 0037135677 scopus 로고    scopus 로고
    • Eight-plasmid system for rapid generation of influenza virus vaccines
    • E. Hoffmann, S. Krauss, D. Perez, R. Webby, and R. G. Webster, Eight-plasmid system for rapid generation of influenza virus vaccines. Vaccine 20, 3165 (2002).
    • (2002) Vaccine , vol.20 , pp. 3165
    • Hoffmann, E.1    Krauss, S.2    Perez, D.3    Webby, R.4    Webster, R.G.5
  • 95
    • 0037227584 scopus 로고    scopus 로고
    • Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics
    • K. Subbarao, H. Chen, D. Swayne, L. Mingay, E. Fodor, G. Brownlee, X. Xu, X. Lu, J. Katz, N. Cox, and Y. Matsuoka, Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics. Virology 305, 192 (2003).
    • (2003) Virology , vol.305 , pp. 192
    • Subbarao, K.1    Chen, H.2    Swayne, D.3    Mingay, L.4    Fodor, E.5    Brownlee, G.6    Xu, X.7    Lu, X.8    Katz, J.9    Cox, N.10    Matsuoka, Y.11
  • 96
    • 77649225565 scopus 로고    scopus 로고
    • Reverse genetic platform for inactivated and live-attenuated influenza vaccine
    • E. J. Jung, K. H. Lee, and B. L. Seong, Reverse genetic platform for inactivated and live-attenuated influenza vaccine. Exp. Mol. Med. 42, 116 (2010).
    • (2010) Exp. Mol. Med. , vol.42 , pp. 116
    • Jung, E.J.1    Lee, K.H.2    Seong, B.L.3
  • 97
    • 15244352743 scopus 로고    scopus 로고
    • Generation of influenza vaccine viruses on Vero cells by reverse genetics: An H5N1 candidate vaccine strain produced under a quality system
    • C. Nicolson, D. Major, J. M. Wood, and J. S. Robertson, Generation of influenza vaccine viruses on Vero cells by reverse genetics: An H5N1 candidate vaccine strain produced under a quality system. Vaccine 23, 2943 (2005).
    • (2005) Vaccine , vol.23 , pp. 2943
    • Nicolson, C.1    Major, D.2    Wood, J.M.3    Robertson, J.S.4
  • 99
    • 45749132153 scopus 로고    scopus 로고
    • Pre-clinical development of cell culture (Vero)-derived H5N1 pandemic vaccines
    • M. K. Howard, O. Kistner, and P. N. Barrett, Pre-clinical development of cell culture (Vero)-derived H5N1 pandemic vaccines. Biol. Chem. 389, 569 (2008).
    • (2008) Biol. Chem. , vol.389 , pp. 569
    • Howard, M.K.1    Kistner, O.2    Barrett, P.N.3
  • 100
    • 34548177946 scopus 로고    scopus 로고
    • An adenovirus vector-mediated reverse genetics system for influenza A virus generation
    • M. Ozawa, H. Goto, T. Horimoto, and Y. Kawaoka, An adenovirus vector-mediated reverse genetics system for influenza A virus generation. J. Virol. 81, 9556 (2007).
    • (2007) J. Virol. , vol.81 , pp. 9556
    • Ozawa, M.1    Goto, H.2    Horimoto, T.3    Kawaoka, Y.4
  • 102
    • 33746293845 scopus 로고    scopus 로고
    • The immunogenicity and efficacy against H5N1 challenge of reverse genetics-derived H5N3 influenza vaccine in ducks and chickens
    • R. G. Webster, R. J. Webby, E. Hoffmann, J. Rodenberg, M. Kumar, H-J Chu, P. Seiler, S. Krauss, and T. Songserm, The immunogenicity and efficacy against H5N1 challenge of reverse genetics-derived H5N3 influenza vaccine in ducks and chickens. Virology 351, 303 (2006).
    • (2006) Virology , vol.351 , pp. 303
    • Webster, R.G.1    Webby, R.J.2    Hoffmann, E.3    Rodenberg, J.4    Kumar, M.5    Chu, H.-J.6    Seiler, P.7    Krauss, S.8    Songserm, T.9
  • 103
    • 25144434656 scopus 로고    scopus 로고
    • Protective efficacy in chickens, geese and ducks of an H5N1-inactivated vaccine developed by reverse genetics
    • G. Tian, S. Zhang, Y. Li, Z. Bu, P. Liu, J. Zhou, C. Li, J. Shi, K. Yu, and H. Chen, Protective efficacy in chickens, geese and ducks of an H5N1-inactivated vaccine developed by reverse genetics. Virology 341, 153 (2005).
    • (2005) Virology , vol.341 , pp. 153
    • Tian, G.1    Zhang, S.2    Li, Y.3    Bu, Z.4    Liu, P.5    Zhou, J.6    Li, C.7    Shi, J.8    Yu, K.9    Chen, H.10
  • 104
    • 70450224083 scopus 로고    scopus 로고
    • The influence of the multi-basic cleavage site of the H5 hemagglutinin on the attenuation, immunogenicity and efficacy of a live attenuated influenza A H5N1 cold-adapted vaccine virus
    • A. L. Suguitan, M. P. Marino, P. D. Desai, L.-M. Chen, Y. Matsuoka, R. O. Donis, H. Jin, D. E. Swayne, G. Kemble, and K. Subbarao, The influence of the multi-basic cleavage site of the H5 hemagglutinin on the attenuation, immunogenicity and efficacy of a live attenuated influenza A H5N1 cold-adapted vaccine virus. Virology 395, 280 (2009).
    • (2009) Virology , vol.395 , pp. 280
    • Suguitan, A.L.1    Marino, M.P.2    Desai, P.D.3    Chen, L.-M.4    Matsuoka, Y.5    Donis, R.O.6    Jin, H.7    Swayne, D.E.8    Kemble, G.9    Subbarao, K.10
  • 106
    • 0035186635 scopus 로고    scopus 로고
    • DNA vaccines: Future strategies and relevance to intracellular pathogens
    • A. K. Sharma and G. K. Khuller, DNA vaccines: Future strategies and relevance to intracellular pathogens. Immunol. Cell. Biol. 79, 537 (2001).
    • (2001) Immunol. Cell. Biol. , vol.79 , pp. 537
    • Sharma, A.K.1    Khuller, G.K.2
  • 107
    • 0027369829 scopus 로고
    • DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody
    • H. L. Davis, M.-L. Michel, and R. G. Whalen, DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Hum. Mol. Genet. 2, 1847 (1993).
    • (1993) Hum. Mol. Genet. , vol.2 , pp. 1847
    • Davis, H.L.1    Michel, M.-L.2    Whalen, R.G.3
  • 108
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • T. Kawai and S. Akira, The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors. Nat. Immunol. 11, 373 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 373
    • Kawai, T.1    Akira, S.2
  • 109
    • 0029050018 scopus 로고
    • A 'senseless' immune response to DNA
    • J. T. Holt, A 'senseless' immune response to DNA. Nat. Med. 1, 407 (1995).
    • (1995) Nat. Med. , vol.1 , pp. 407
    • Holt, J.T.1
  • 110
    • 0033664689 scopus 로고    scopus 로고
    • DNA vaccination: Antigen presentation and the induction of immunity
    • D. J. Shedlock and D. B. Weiner, DNA vaccination: Antigen presentation and the induction of immunity. J. Leukoc. Biol. 68, 793 (2000).
    • (2000) J. Leukoc. Biol. , vol.68 , pp. 793
    • Shedlock, D.J.1    Weiner, D.B.2
  • 111
    • 34250843124 scopus 로고    scopus 로고
    • Potential of transfected muscle cells to contribute to DNA vaccine immunogenicity
    • H. Shirota, L. Petrenko, C. Hong, and D. M. Klinman, Potential of transfected muscle cells to contribute to DNA vaccine immunogenicity. J. Immunol. 179, 329 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 329
    • Shirota, H.1    Petrenko, L.2    Hong, C.3    Klinman, D.M.4
  • 112
    • 0028902839 scopus 로고
    • Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines
    • Z. Xiang and H. C. J. Ertl, Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 2, 129 (1995).
    • (1995) Immunity , vol.2 , pp. 129
    • Xiang, Z.1    Ertl, H.C.J.2
  • 113
    • 0031252387 scopus 로고    scopus 로고
    • Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens
    • E. Okada, S. Sasaki, N. Ishii, I. Aoki, T. Yasuda, K. Nishioka, J. Fukushima, J. Miyazaki, B. Wahren, and K. Okuda, Intranasal immunization of a DNA vaccine with IL-12- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-expressing plasmids in liposomes induces strong mucosal and cell-mediated immune responses against HIV-1 antigens. J. Immunol. 159, 3638 (1997).
    • (1997) J. Immunol. , vol.159 , pp. 3638
    • Okada, E.1    Sasaki, S.2    Ishii, N.3    Aoki, I.4    Yasuda, T.5    Nishioka, K.6    Fukushima, J.7    Miyazaki, J.8    Wahren, B.9    Okuda, K.10
  • 114
    • 0032568415 scopus 로고    scopus 로고
    • Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction
    • J. S. Boyle, J. L. Brady, and A. M. Lew, Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction. Nature 392, 408 (1998).
    • (1998) Nature , vol.392 , pp. 408
    • Boyle, J.S.1    Brady, J.L.2    Lew, A.M.3
  • 115
    • 0031060327 scopus 로고    scopus 로고
    • Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2
    • Y. Chow, W. Huang, W. Chi, Y. Chu, and M. Tao, Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2. J. Virol. 71, 169 (1997).
    • (1997) J. Virol. , vol.71 , pp. 169
    • Chow, Y.1    Huang, W.2    Chi, W.3    Chu, Y.4    Tao, M.5
  • 117
    • 60449097497 scopus 로고    scopus 로고
    • Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules
    • G. J. Logan, L. Wang, M. Zheng, S. L. Ginn, R. L. Coppel, and I. E. Alexander, Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules. Gene Ther. 16, 200 (2008).
    • (2008) Gene Ther. , vol.16 , pp. 200
    • Logan, G.J.1    Wang, L.2    Zheng, M.3    Ginn, S.L.4    Coppel, R.L.5    Alexander, I.E.6
  • 118
    • 67349094613 scopus 로고    scopus 로고
    • Evaluation of conserved and variable influenza antigens for immunization against different isolates of H5N1 viruses
    • A, Patel, K. Tran, M. Gray, Y. Li, Z. Ao, X. Yao, D. Kobasa, and G. P. Kobinger, Evaluation of conserved and variable influenza antigens for immunization against different isolates of H5N1 viruses. Vaccine 27, 3083 (2009).
    • (2009) Vaccine , vol.27 , pp. 3083
    • Patel, A.1    Tran, K.2    Gray, M.3    Li, Y.4    Ao, Z.5    Yao, X.6    Kobasa, D.7    Kobinger, G.P.8
  • 119
    • 27644544183 scopus 로고    scopus 로고
    • Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein
    • S. L. Epstein, W.-P. Kong, J. A. Misplon, C.-Y. Lo, T. M. Tumpey, L. Xu, and G. J. Nabel, Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein. Vaccine 23, 5404 (2005).
    • (2005) Vaccine , vol.23 , pp. 5404
    • Epstein, S.L.1    Kong, W.-P.2    Misplon, J.A.3    Lo, C.-Y.4    Tumpey, T.M.5    Xu, L.6    Nabel, G.J.7
  • 120
    • 51649100250 scopus 로고    scopus 로고
    • A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses
    • M.-W. Chen, T.-J. R. Cheng, Y. Huang, J.-T. Jan, S.-H. Ma, A. L. Yu, C. H. Wong, and D. D. Ho, A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses. PNAS 105, 13538 (2008).
    • (2008) PNAS , vol.105 , pp. 13538
    • Chen, M.-W.1    Cheng, T.-J.R.2    Huang, Y.3    Jan, J.-T.4    Ma, S.-H.5    Yu, A.L.6    Wong, C.H.7    Ho, D.D.8
  • 121
    • 77956661888 scopus 로고    scopus 로고
    • Comparative efficacy of hemagglutinin, nucleoprotein, and matrix 2 protein gene-based vaccination against H5N1 influenza in mouse and ferret
    • S. S. Rao, W.-P. Kong, C.-J. Wei, N. Van Hoeven, J. P. Gorres, M. Nason, H. Andersen, T. M. Tumpey, and G. J. Nabel, Comparative efficacy of hemagglutinin, nucleoprotein, and matrix 2 protein gene-based vaccination against H5N1 influenza in mouse and ferret. PLoS One 5, e9812 (2010).
    • (2010) PLoS One , vol.5
    • Rao, S.S.1    Kong, W.-P.2    Wei, C.-J.3    Van Hoeven, N.4    Gorres, J.P.5    Nason, M.6    Andersen, H.7    Tumpey, T.M.8    Nabel, G.J.9
  • 122
    • 46349102241 scopus 로고    scopus 로고
    • Plasmid DNA-based vaccines protect mice and ferrets against lethal challenge with A/Vietnam/1203/04 (H5N1) influenza virus
    • P. A. Lalor, R. J. Webby, J. Morrow, D. Rusalov, D. C. Kaslow, A. Rolland, and L. R. Smith, Plasmid DNA-based vaccines protect mice and ferrets against lethal challenge with A/Vietnam/1203/04 (H5N1) influenza virus. J. Infect. Dis. 197, 1643 (2008).
    • (2008) J. Infect. Dis. , vol.197 , pp. 1643
    • Lalor, P.A.1    Webby, R.J.2    Morrow, J.3    Rusalov, D.4    Kaslow, D.C.5    Rolland, A.6    Smith, L.R.7
  • 123
    • 79951785009 scopus 로고    scopus 로고
    • Broad humoral and cellular immunity elicited by a bivalent DNA vaccine encoding HA and NP genes from an H5N1 virus
    • K. Xu, Z-Y. Ling, L. Sun, Y. Xu, C. Bian, Y. He, W. Lu, Z. Chen, and B. Sun, Broad humoral and cellular immunity elicited by a bivalent DNA vaccine encoding HA and NP genes from an H5N1 virus. Viral Immunol. 24, 45 (2011).
    • (2011) Viral Immunol. , vol.24 , pp. 45
    • Xu, K.1    Ling, Z.-Y.2    Sun, L.3    Xu, Y.4    Bian, C.5    He, Y.6    Lu, W.7    Chen, Z.8    Sun, B.9
  • 124
    • 79952244799 scopus 로고    scopus 로고
    • The virus-induced signaling adaptor molecule enhances DNA-raised immune protection against H5N1 influenza virus infection in mice
    • M. Luo, X. Qu, R. Pan, D. Zhu, Y. Zhang, J. Wu, and Z. Pan, The virus-induced signaling adaptor molecule enhances DNA-raised immune protection against H5N1 influenza virus infection in mice. Vaccine 29, 2561 (2011).
    • (2011) Vaccine , vol.29 , pp. 2561
    • Luo, M.1    Qu, X.2    Pan, R.3    Zhu, D.4    Zhang, Y.5    Wu, J.6    Pan, Z.7
  • 126
    • 66149101000 scopus 로고    scopus 로고
    • Intranasal vaccination with 1918 influenza virus-like particles protects mice and ferrets from lethal 1918 and H5N1 influenza virus challenge
    • L. A. Perrone, A. Ahmad, V. Veguilla, X. Lu, G. Smith, J. M. Katz, P. Pushko, and T. M. Tumpey, Intranasal vaccination with 1918 influenza virus-like particles protects mice and ferrets from lethal 1918 and H5N1 influenza virus challenge. J. Virol. 83, 5726 (2009).
    • (2009) J. Virol. , vol.83 , pp. 5726
    • Perrone, L.A.1    Ahmad, A.2    Veguilla, V.3    Lu, X.4    Smith, G.5    Katz, J.M.6    Pushko, P.7    Tumpey, T.M.8
  • 128
    • 77953630380 scopus 로고    scopus 로고
    • Egg-independent vaccine strategies for highly pathogenic H5N1 influenza viruses
    • A. Pandey, N. Singh, and S. K. Mittal, Egg-independent vaccine strategies for highly pathogenic H5N1 influenza viruses. Hum. Vaccines 6, 178 (2010).
    • (2010) Hum. Vaccines , vol.6 , pp. 178
    • Pandey, A.1    Singh, N.2    Mittal, S.K.3
  • 129
  • 130
    • 77950656840 scopus 로고    scopus 로고
    • Influenza virus-like particles as pandemic vaccines
    • R. W. Compans and W. A. Orenstein, Influenza virus-like particles as pandemic vaccines. Curr. Top. Microbiol. 333, 269 (2009).
    • (2009) Curr. Top. Microbiol. , vol.333 , pp. 269
    • Compans, R.W.1    Orenstein, W.A.2
  • 131
    • 77955677664 scopus 로고    scopus 로고
    • Proteinbased nanosystems: Virus-like-particles in modern vaccine development
    • C. Reichel, C. Ruehland, C. O. A. Reiser, and J. Hess, Proteinbased nanosystems: Virus-like-particles in modern vaccine development. J. Biomed. Nanotechnol. 2, 186 (2006).
    • (2006) J. Biomed. Nanotechnol. , vol.2 , pp. 186
    • Reichel, C.1    Ruehland, C.2    Reiser, C.O.A.3    Hess, J.4
  • 132
    • 77955050363 scopus 로고    scopus 로고
    • In vitro stimulation of human influenza-specific CD8+ T cells by dendritic cells pulsed with an influenza virus-like particle (VLP) vaccine
    • H. Song, V. Wittman, A. Byers, T. Tapia, B. Zhou, W. Warren, P. Heaton, and K. Connolly, In vitro stimulation of human influenza-specific CD8+ T cells by dendritic cells pulsed with an influenza virus-like particle (VLP) vaccine. Vaccine 28, 5524 (2010).
    • (2010) Vaccine , vol.28 , pp. 5524
    • Song, H.1    Wittman, V.2    Byers, A.3    Tapia, T.4    Zhou, B.5    Warren, W.6    Heaton, P.7    Connolly, K.8
  • 134
    • 67849086592 scopus 로고    scopus 로고
    • Virus-like particle vaccine comprised of the HA, NA, and M1 proteins of an avian isolated H5N1 influenza virus induces protective immunity against homologous and heterologous strains in mice
    • P. Tao, M. Luo, D. Zhu, S. Qu, Z. Yang, M. Gao, D. Guo, and Z. Pan, Virus-like particle vaccine comprised of the HA, NA, and M1 proteins of an avian isolated H5N1 influenza virus induces protective immunity against homologous and heterologous strains in mice. Viral Immunol. 22, 273 (2009).
    • (2009) Viral Immunol. , vol.22 , pp. 273
    • Tao, P.1    Luo, M.2    Zhu, D.3    Qu, S.4    Yang, Z.5    Gao, M.6    Guo, D.7    Pan, Z.8
  • 137
    • 77954521860 scopus 로고    scopus 로고
    • Intradermal vaccination with influenza virus-like particles by using microneedles induces protection superior to that with intramuscular immunization
    • F.-S. Quan, Y.-C. Kim, A. Vunnava, D.-G. Yoo, J.-M. Song, M. R. Prausnitz, R. W. Compans, and S. M. Kang, Intradermal vaccination with influenza virus-like particles by using microneedles induces protection superior to that with intramuscular immunization. J. Virol. 84, 7760 (2010).
    • (2010) J. Virol. , vol.84 , pp. 7760
    • Quan, F.-S.1    Kim, Y.-C.2    Vunnava, A.3    Yoo, D.-G.4    Song, J.-M.5    Prausnitz, M.R.6    Compans, R.W.7    Kang, S.M.8
  • 138
    • 84860380354 scopus 로고    scopus 로고
    • A computationally optimized hemagglutinin virus-like particle vaccine elicits broadly reactive antibodies that protect nonhuman primates from H5N1 infection
    • B. M. Giles, C. J. Crevar, D. M. Carter, S. J. Bissel, S. Schultz- Cherry, C. A. Wiley, and T. M. Ross, A computationally optimized hemagglutinin virus-like particle vaccine elicits broadly reactive antibodies that protect nonhuman primates from H5N1 infection. J. Infect. Dis. 205, 1562 (2012).
    • (2012) J. Infect. Dis. , vol.205 , pp. 1562
    • Giles, B.M.1    Crevar, C.J.2    Carter, D.M.3    Bissel, S.J.4    Schultz- Cherry, S.5    Wiley, C.A.6    Ross, T.M.7
  • 142
    • 77949412710 scopus 로고    scopus 로고
    • Gastrointestinal delivery of baculovirus displaying influenza virus hemagglutinin protects mice against heterologous H5N1 infection
    • M. Prabakaran, S. Madhan, N. Prabhu, J. Qiang, and J. Kwang, Gastrointestinal delivery of baculovirus displaying influenza virus hemagglutinin protects mice against heterologous H5N1 infection. J. Virol. 84, 3201 (2010).
    • (2010) J. Virol. , vol.84 , pp. 3201
    • Prabakaran, M.1    Madhan, S.2    Prabhu, N.3    Qiang, J.4    Kwang, J.5
  • 143
    • 78149410526 scopus 로고    scopus 로고
    • Protection against multiple influenza A virus subtypes by intranasal administration of recombinant nucleoprotein
    • L. Guo, M. Zheng, Y. Ding, D. Li, Z. Yang, H. Wang, Q. Chen, Z. Sui, F. Fang, and Z. Chen, Protection against multiple influenza A virus subtypes by intranasal administration of recombinant nucleoprotein. Arch. Virol. 155, 1765 (2010).
    • (2010) Arch. Virol. , vol.155 , pp. 1765
    • Guo, L.1    Zheng, M.2    Ding, Y.3    Li, D.4    Yang, Z.5    Wang, H.6    Chen, Q.7    Sui, Z.8    Fang, F.9    Chen, Z.10
  • 144
    • 70350567189 scopus 로고    scopus 로고
    • Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses
    • G. E. Price, M. R. Soboleski, C.-Y. Lo, J. A. Misplon, C. Pappas, K. V. Houser, T. M. Tumpey, and S. L. Epstein, Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses. Vaccine 27, 6512 (2009).
    • (2009) Vaccine , vol.27 , pp. 6512
    • Price, G.E.1    Soboleski, M.R.2    Lo, C.-Y.3    Misplon, J.A.4    Pappas, C.5    Houser, K.V.6    Tumpey, T.M.7    Epstein, S.L.8
  • 147
    • 68849097242 scopus 로고    scopus 로고
    • Preparation and immune activity analysis of H5N1 subtype avian influenza virus recombinant protein-based vaccine
    • Q. M. Xie, J. Ji, L. Q. Du, Y. C. Cao, L. Wei, C. Y. Xue, J. P. Qin, J. Y. Ma, and Y. Z. Bi, Preparation and immune activity analysis of H5N1 subtype avian influenza virus recombinant protein-based vaccine. Poult. Sci. 88, 1608 (2009).
    • (2009) Poult. Sci. , vol.88 , pp. 1608
    • Xie, Q.M.1    Ji, J.2    Du, L.Q.3    Cao, Y.C.4    Wei, L.5    Xue, C.Y.6    Qin, J.P.7    Ma, J.Y.8    Bi, Y.Z.9
  • 151
    • 79957796724 scopus 로고    scopus 로고
    • Recombinant trimeric HA protein immunogenicity of H5N1 avian influenza viruses and their combined use with inactivated or adenovirus vaccines
    • S.-C. Lin, M.-H. Huang, P.-C. Tsou, L.-M. Huang, P. Chong, and S.-C. Wu, Recombinant trimeric HA protein immunogenicity of H5N1 avian influenza viruses and their combined use with inactivated or adenovirus vaccines. PLoS ONE 6, e20052 (2011).
    • (2011) PLoS ONE , vol.6
    • Lin, S.-C.1    Huang, M.-H.2    Tsou, P.-C.3    Huang, L.-M.4    Chong, P.5    Wu, S.-C.6
  • 155
    • 0032615727 scopus 로고    scopus 로고
    • Deceptive imprinting: Insights into mechanisms of immune evasion and vaccine development
    • P. L. Nara and D. S. Roland, Deceptive imprinting: Insights into mechanisms of immune evasion and vaccine development. Adv. Veter. Med. AP. 41, 115 (1999).
    • (1999) Adv. Veter. Med. AP. , vol.41 , pp. 115
    • Nara, P.L.1    Roland, D.S.2
  • 156
    • 0033990796 scopus 로고    scopus 로고
    • Protection against diverse highly pathogenic H5 avian influenza viruses in chickens immunized with a recombinant fowlpox vaccine containing an H5 avian influenza hemagglutinin gene insert
    • D. E. Swayne, M. Garcia, J. R. Beck, N. Kinney, and D. L. Suarez, Protection against diverse highly pathogenic H5 avian influenza viruses in chickens immunized with a recombinant fowlpox vaccine containing an H5 avian influenza hemagglutinin gene insert. Vaccine 18, 1088 (2000).
    • (2000) Vaccine , vol.18 , pp. 1088
    • Swayne, D.E.1    Garcia, M.2    Beck, J.R.3    Kinney, N.4    Suarez, D.L.5
  • 158
    • 34247618920 scopus 로고    scopus 로고
    • Efficacy of a fowlpox-vectored avian influenza H5 vaccine against Asian H5N1 highly pathogenic avian influenza virus challenge
    • M. Bublot, N. Pritchard, J. S. Cruz, T. R. Mickle, P. Selleck, and D. E. Swayne, Efficacy of a fowlpox-vectored avian influenza H5 vaccine against Asian H5N1 highly pathogenic avian influenza virus challenge. Avian Dis. 51, 498 (2007).
    • (2007) Avian Dis. , vol.51 , pp. 498
    • Bublot, M.1    Pritchard, N.2    Cruz, J.S.3    Mickle, T.R.4    Selleck, P.5    Swayne, D.E.6
  • 161
    • 61849120205 scopus 로고    scopus 로고
    • Safety, immunogenicity and efficacy of poxvirusbased vector vaccines expressing the haemagglutinin gene of a highly pathogenic H5N1 avian influenza virus in pigs
    • C. S. Kyriakis, A. De Vleeschauwer, F. Barbe, M. Bublot, and K. Van Reeth, Safety, immunogenicity and efficacy of poxvirusbased vector vaccines expressing the haemagglutinin gene of a highly pathogenic H5N1 avian influenza virus in pigs. Vaccine 27, 2258 (2009).
    • (2009) Vaccine , vol.27 , pp. 2258
    • Kyriakis, C.S.1    De Vleeschauwer, A.2    Barbe, F.3    Bublot, M.4    Van Reeth, K.5
  • 165
    • 84881545779 scopus 로고    scopus 로고
    • Prime-boost vaccination with recombinant H5-fowlpox and Newcastle disease virus vectors affords lasting protection in SPF Muscovy ducks against highly pathogenic H5N1 influenza virus
    • E. Niqueux, O. Guionie, M. Amelot, and V. Jestin, Prime-boost vaccination with recombinant H5-fowlpox and Newcastle disease virus vectors affords lasting protection in SPF Muscovy ducks against highly pathogenic H5N1 influenza virus. Vaccine 31, 4121 (2013).
    • (2013) Vaccine , vol.31 , pp. 4121
    • Niqueux, E.1    Guionie, O.2    Amelot, M.3    Jestin, V.4
  • 166
    • 84884303756 scopus 로고    scopus 로고
    • Crossprotective immunity against influenza A/H1N1 virus challenge in mice immunized with recombinant vaccine expressing HA gene of influenza A/H5N1 virus
    • S. Yang, S. Niu, Z. Guo, Y. Yuan, K. Xue, S. Liu, and H. Jin, Crossprotective immunity against influenza A/H1N1 virus challenge in mice immunized with recombinant vaccine expressing HA gene of influenza A/H5N1 virus. Virol. J. 10, 291 (2013).
    • (2013) Virol. J. , vol.10 , pp. 291
    • Yang, S.1    Niu, S.2    Guo, Z.3    Yuan, Y.4    Xue, K.5    Liu, S.6    Jin, H.7
  • 167
    • 84863037871 scopus 로고    scopus 로고
    • Mucosal and systemic immune responses induced by recombinant lactobacillus expressing the hemagglutinin of the avian influenza virus
    • Z. Wang, Q. Yu, J. Gao, and Q. Yang, Mucosal and systemic immune responses induced by recombinant lactobacillus expressing the hemagglutinin of the avian influenza virus. Clin. Vaccine Immunol. 19, 174 (2012).
    • (2012) Clin. Vaccine Immunol. , vol.19 , pp. 174
    • Wang, Z.1    Yu, Q.2    Gao, J.3    Yang, Q.4
  • 168
    • 34547849481 scopus 로고    scopus 로고
    • Breaking the immunogenicity barrier of bird flu vaccines
    • S. Sambhara and G. A. Poland, Breaking the immunogenicity barrier of bird flu vaccines. Lancet 370, 544 (2007).
    • (2007) Lancet , vol.370 , pp. 544
    • Sambhara, S.1    Poland, G.A.2
  • 169
    • 34547837401 scopus 로고    scopus 로고
    • Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: A randomised controlled trial
    • I. Leroux-Roels, A. Borkowski, T. Vanwolleghem, M. Dramé, F. Clement, E. Hons, J. M. Devaster, and G. Leroux-Roels, Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: A randomised controlled trial. Lancet 370, 580 (2007).
    • (2007) Lancet , vol.370 , pp. 580
    • Leroux-Roels, I.1    Borkowski, A.2    Vanwolleghem, T.3    Dramé, M.4    Clement, F.5    Hons, E.6    Devaster, J.M.7    Leroux-Roels, G.8
  • 171
    • 77955597687 scopus 로고    scopus 로고
    • Unmet needs in modern vaccinology: Adjuvants to improve the immune response
    • G. Leroux-Roels, Unmet needs in modern vaccinology: Adjuvants to improve the immune response. Vaccine 28, C25 (2010).
    • (2010) Vaccine , vol.28
    • Leroux-Roels, G.1
  • 172
    • 77957930898 scopus 로고    scopus 로고
    • MF59 as a vaccine adjuvant: A review of safety and immunogenicity
    • H. E. Sahly, MF59 as a vaccine adjuvant: A review of safety and immunogenicity. Expert Rev. Vaccines 9, 1135 (2010).
    • (2010) Expert Rev. Vaccines , vol.9 , pp. 1135
    • Sahly, H.E.1
  • 173
    • 34147181229 scopus 로고    scopus 로고
    • Inactivated influenza H5N1 whole-virus vaccine with aluminum adjuvant induces homologous and heterologous protective immunities against lethal challenge with highly pathogenic H5N1 avian influenza viruses in a mouse model
    • A. Ninomiya, M. Imai, M. Tashiro, and T. Odagiri, Inactivated influenza H5N1 whole-virus vaccine with aluminum adjuvant induces homologous and heterologous protective immunities against lethal challenge with highly pathogenic H5N1 avian influenza viruses in a mouse model. Vaccine 25, 3554 (2007).
    • (2007) Vaccine , vol.25 , pp. 3554
    • Ninomiya, A.1    Imai, M.2    Tashiro, M.3    Odagiri, T.4
  • 174
    • 39749159136 scopus 로고    scopus 로고
    • Vaccination of macaques with adjuvanted formalininactivated influenza A virus (H5N1) vaccines: Protection against H5N1 challenge without disease enhancement
    • C. Ruat, C. Caillet, A. Bidaut, J. Simon, and A. D. M. E. Osterhaus, Vaccination of macaques with adjuvanted formalininactivated influenza A virus (H5N1) vaccines: Protection against H5N1 challenge without disease enhancement. J. Virol. 82, 2565 (2008).
    • (2008) J. Virol. , vol.82 , pp. 2565
    • Ruat, C.1    Caillet, C.2    Bidaut, A.3    Simon, J.4    Osterhaus, A.D.M.E.5
  • 175
    • 51549100095 scopus 로고    scopus 로고
    • Prepandemic influenza vaccine H5N1 (split virion, inactivated, adjuvanted) [Prepandrix(TM)]: A review of its use as an active immunization against influenza A subtype H5N1 virus
    • N. J. Carter and G. L. Plosker, Prepandemic influenza vaccine H5N1 (split virion, inactivated, adjuvanted) [Prepandrix(TM)]: A review of its use as an active immunization against influenza A subtype H5N1 virus. Bio. Drugs 22, 279 (2008).
    • (2008) Bio. Drugs , vol.22 , pp. 279
    • Carter, N.J.1    Plosker, G.L.2
  • 177
    • 65449157320 scopus 로고    scopus 로고
    • Current status and progress of prepandemic and pandemic influenza vaccine development
    • 323-344
    • I. Leroux-Roels 323-344 G. Leroux-Roels, Current status and progress of prepandemic and pandemic influenza vaccine development. Expert Rev. Vaccines 8, 401 (2009).
    • (2009) Expert Rev. Vaccines , vol.8 , pp. 401
    • Leroux-Roels, I.1    Leroux-Roels, G.2
  • 178
    • 71249164116 scopus 로고    scopus 로고
    • Priming with AS03A-adjuvanted H5N1 influenza vaccine improves the kinetics, magnitude and durability of the immune response after a heterologous booster vaccination: An open non-randomised extension of a double-blind randomised primary study
    • I. Leroux-Roels, F. Roman, S. Forgus, C. Maes, F. De Boever, M. Dramé, P. Gillard, R. van der Most, M. Van Mechelen, E. Hanon, and G. Lerous-Roels, Priming with AS03A-adjuvanted H5N1 influenza vaccine improves the kinetics, magnitude and durability of the immune response after a heterologous booster vaccination: An open non-randomised extension of a double-blind randomised primary study. Vaccine 28, 849 (2010).
    • (2010) Vaccine , vol.28 , pp. 849
    • Leroux-Roels, I.1    Roman, F.2    Forgus, S.3    Maes, C.4    De Boever, F.5    Dramé, M.6    Gillard, P.7    Van Der Most, R.8    Van Mechelen, M.9    Hanon, E.10    Lerous-Roels, G.11
  • 179
    • 71349088027 scopus 로고    scopus 로고
    • Dose ranging of adjuvant and antigen in a cell culture H5N1 influenza vaccine: Safety and immunogenicity of a phase 1/2 clinical trial
    • W. Keitel, N. Groth, M. Lattanzi, M. Praus, A. K. Hilbert, A. Borkowski, and T. F. Tsai, Dose ranging of adjuvant and antigen in a cell culture H5N1 influenza vaccine: Safety and immunogenicity of a phase 1/2 clinical trial. Vaccine 28, 840 (2010).
    • (2010) Vaccine , vol.28 , pp. 840
    • Keitel, W.1    Groth, N.2    Lattanzi, M.3    Praus, M.4    Hilbert, A.K.5    Borkowski, A.6    Tsai, T.F.7
  • 183
    • 0033577349 scopus 로고    scopus 로고
    • ISCOM vaccine induced protection against a lethal challenge with a human H5N1 influenza virus
    • G. F. Rimmelzwaan, E. C. J. Claas, G. Van Amerongen, J. C. de Jong, and A. D. M. E. Osterhaus, ISCOM vaccine induced protection against a lethal challenge with a human H5N1 influenza virus. Vaccine 17, 1355 (1999).
    • (1999) Vaccine , vol.17 , pp. 1355
    • Rimmelzwaan, G.F.1    Claas, E.C.J.2    Van Amerongen, G.3    De Jong, J.C.4    Osterhaus, A.D.M.E.5
  • 184
    • 0028172934 scopus 로고
    • A type-specific avian influenza virus subunit vaccine for turkeys: Induction of protective immunity to challenge infection
    • S. Kodihalli, V. Sivanandan, K. V. Nagaraja, D. Shaw, and D. A. Halvorson, A type-specific avian influenza virus subunit vaccine for turkeys: Induction of protective immunity to challenge infection. Vaccine 12, 1467 (1994).
    • (1994) Vaccine , vol.12 , pp. 1467
    • Kodihalli, S.1    Sivanandan, V.2    Nagaraja, K.V.3    Shaw, D.4    Halvorson, D.A.5
  • 185
    • 77949711408 scopus 로고    scopus 로고
    • Platycodin D improves the immunogenicity of newcastle disease virus-based recombinant avian influenza vaccine in mice
    • Y. Xie, H.-X. Sun, and D. Li, Platycodin D improves the immunogenicity of newcastle disease virus-based recombinant avian influenza vaccine in mice. Chem. Biodivers 7, 677 (2010).
    • (2010) Chem. Biodivers , vol.7 , pp. 677
    • Xie, Y.1    Sun, H.-X.2    Li, D.3
  • 188
    • 56649108016 scopus 로고    scopus 로고
    • Engagement of TLR signaling as adjuvant: Towards smarter vaccine and beyond
    • A. Lahiri, P. Das, and D. Chakravortty, Engagement of TLR signaling as adjuvant: Towards smarter vaccine and beyond. Vaccine 26, 6777 (2008).
    • (2008) Vaccine , vol.26 , pp. 6777
    • Lahiri, A.1    Das, P.2    Chakravortty, D.3
  • 191
    • 77956635171 scopus 로고    scopus 로고
    • An adjuvant for the induction of potent, protective humoral responses to an H5N1 influenza virus vaccine with antigen-sparing effect in mice
    • Y.-F. Lau, L.-H. Tang, A. W. McCall, E.-E. Ooi, and K. Subbarao, An adjuvant for the induction of potent, protective humoral responses to an H5N1 influenza virus vaccine with antigen-sparing effect in mice. J. Virol. 84, 8639 (2010).
    • (2010) J. Virol. , vol.84 , pp. 8639
    • Lau, Y.-F.1    Tang, L.-H.2    McCall, A.W.3    Ooi, E.-E.4    Subbarao, K.5
  • 193
    • 53449091640 scopus 로고    scopus 로고
    • Protective immunity against influenza H5N1 virus challenge in mice by intranasal coadministration of baculovirus surface-displayed HA and recombinant CTB as an adjuvant
    • M. Prabakaran, S. Velumani, F. He, A. K. Karuppannan, G. Y. Geng, L. K. Yin, and J. Kwang, Protective immunity against influenza H5N1 virus challenge in mice by intranasal coadministration of baculovirus surface-displayed HA and recombinant CTB as an adjuvant. Virology 380, 412 (2008).
    • (2008) Virology , vol.380 , pp. 412
    • Prabakaran, M.1    Velumani, S.2    He, F.3    Karuppannan, A.K.4    Geng, G.Y.5    Yin, L.K.6    Kwang, J.7
  • 194
    • 78049278349 scopus 로고    scopus 로고
    • Cross-clade protection against HPAI H5N1 influenza virus challenge in BALB/c mice intranasally administered adjuvant-combined influenza vaccine
    • P. Yang, C. Tang, D. Luo, Z. Zhan, L. Xing, Y. Duan, W. Jia, D. Peng, X. Liu, and X. Wang, Cross-clade protection against HPAI H5N1 influenza virus challenge in BALB/c mice intranasally administered adjuvant-combined influenza vaccine. Vet. Microbiol. 146, 17 (2010).
    • (2010) Vet. Microbiol. , vol.146 , pp. 17
    • Yang, P.1    Tang, C.2    Luo, D.3    Zhan, Z.4    Xing, L.5    Duan, Y.6    Jia, W.7    Peng, D.8    Liu, X.9    Wang, X.10
  • 195
    • 72049128598 scopus 로고    scopus 로고
    • Safety and immunogenicity of an influenza vaccine A/H5N1 (A/Vietnam/1194/2004) when coadministered with a heat-labile enterotoxin (LT) adjuvant patch
    • G. M. Glenn, D. N. Thomas, K. L. Poffenberger, D. C. Flyer, L. R. Ellingsworth, B. H. Andersen, and S. A. Frech, Safety and immunogenicity of an influenza vaccine A/H5N1 (A/Vietnam/1194/2004) when coadministered with a heat-labile enterotoxin (LT) adjuvant patch. Vaccine 27, G60 (2009).
    • (2009) Vaccine , vol.27
    • Glenn, G.M.1    Thomas, D.N.2    Poffenberger, K.L.3    Flyer, D.C.4    Ellingsworth, L.R.5    Andersen, B.H.6    Frech, S.A.7
  • 204
    • 2942627626 scopus 로고    scopus 로고
    • Hydrophobicity: An ancient damage-associated molecular pattern that initiates innate immune responses
    • S. Y. Seong and P. Matzinger, Hydrophobicity: An ancient damage-associated molecular pattern that initiates innate immune responses. Nat. Rev. Immunol. 4, 469 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 469
    • Seong, S.Y.1    Matzinger, P.2
  • 205
    • 9244253168 scopus 로고    scopus 로고
    • Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens
    • W. Jiang, R. K. Gupta, M. C. Deshpande, and S. P. Schwendeman, Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens. Adv. Drug Deliver. Rev. 57, 391 (2005).
    • (2005) Adv. Drug Deliver. Rev. , vol.57 , pp. 391
    • Jiang, W.1    Gupta, R.K.2    Deshpande, M.C.3    Schwendeman, S.P.4
  • 206
    • 0037462997 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    • J. Panyam and V. Labhasetwar, Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliver. Rev. 55, 329 (2003).
    • (2003) Adv. Drug Deliver. Rev. , vol.55 , pp. 329
    • Panyam, J.1    Labhasetwar, V.2
  • 207
    • 80052270541 scopus 로고    scopus 로고
    • Targeting dendritic cells with nano-particulate PLGA cancer vaccine formulations
    • S. Hamdy, A. Haddadi, R. W. Hung, and A. Lavasanifar, Targeting dendritic cells with nano-particulate PLGA cancer vaccine formulations. Adv. Drug Deliver. Rev. 63, 943 (2011).
    • (2011) Adv. Drug Deliver. Rev. , vol.63 , pp. 943
    • Hamdy, S.1    Haddadi, A.2    Hung, R.W.3    Lavasanifar, A.4
  • 208
    • 70450221930 scopus 로고    scopus 로고
    • Biodegradable polymeric nanoparticles based drug delivery systems
    • A. Kumari, S. K. Yadav, and S. C. Yadav, Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surface B 75, 1 (2010).
    • (2010) Colloids Surface B , vol.75 , pp. 1
    • Kumari, A.1    Yadav, S.K.2    Yadav, S.C.3
  • 209
    • 82455209039 scopus 로고    scopus 로고
    • Development and characterization of chitosan coated poly-(e-caprolactone) nanoparticulate system for effective immunization against influenza
    • N. K. Gupta, P. Tomar, V. Sharma, and V. K. Dixit, Development and characterization of chitosan coated poly-(e-caprolactone) nanoparticulate system for effective immunization against influenza. Vaccine 29, 9026 (2011).
    • (2011) Vaccine , vol.29 , pp. 9026
    • Gupta, N.K.1    Tomar, P.2    Sharma, V.3    Dixit, V.K.4
  • 212
    • 77149132443 scopus 로고    scopus 로고
    • Preparation and immunological effectiveness of a Swine influenza DNA vaccine encapsulating in PLGA microspheres
    • K. Zhao, G.-X. Li, Y.-Y. Jin, H.-X. Wei, Q.-S. Sun, T.-T. Huang, Y.-F. Wang, and G.-Z. Tong, Preparation and immunological effectiveness of a Swine influenza DNA vaccine encapsulating in PLGA microspheres. J. Microencapsul. 27, 178 (2010).
    • (2010) J. Microencapsul. , vol.27 , pp. 178
    • Zhao, K.1    Li, G.-X.2    Jin, Y.-Y.3    Wei, H.-X.4    Sun, Q.-S.5    Huang, T.-T.6    Wang, Y.-F.7    Tong, G.-Z.8
  • 213
    • 79961079794 scopus 로고    scopus 로고
    • Intracellular targeting of PLGA nanoparticles encapsulating antigenic peptide to the endoplasmic reticulum of dendritic cells and its effect on antigen cross presentation in vitro
    • H. Sneh-Edri, D. Likhtenshtein, and D. Stepensky, Intracellular targeting of PLGA nanoparticles encapsulating antigenic peptide to the endoplasmic reticulum of dendritic cells and its effect on antigen cross presentation in vitro. Mol. Pharm. 8, 1266 (2011).
    • (2011) Mol. Pharm. , vol.8 , pp. 1266
    • Sneh-Edri, H.1    Likhtenshtein, D.2    Stepensky, D.3
  • 214
    • 84871463627 scopus 로고    scopus 로고
    • Improving anti-tumor activity with polymeric micells entrapping paclitaxel in pulmonary carcinoma
    • C. Gong, Y. Xie, Q. Wu, Y. Wang, S. Deng, D. Xiong, L. Liu, X. M. Z. Qian, and Y. Wei, Improving anti-tumor activity with polymeric micells entrapping paclitaxel in pulmonary carcinoma. Nanoscale 4, 6004 (2012).
    • (2012) Nanoscale , vol.4 , pp. 6004
    • Gong, C.1    Xie, Y.2    Wu, Q.3    Wang, Y.4    Deng, S.5    Xiong, D.6    Liu, L.7    Qian, X.M.Z.8    Wei, Y.9
  • 215
    • 31544467293 scopus 로고    scopus 로고
    • Diphtheria toxoid loaded poly-(e-caprolactone) nanoparticles as mucosal vaccine delivery systems
    • J. Singh, S. Pandit, V. W. Bramwell, and H. O. Alpar, Diphtheria toxoid loaded poly-(e-caprolactone) nanoparticles as mucosal vaccine delivery systems. Methods 38, 96 (2006).
    • (2006) Methods , vol.38 , pp. 96
    • Singh, J.1    Pandit, S.2    Bramwell, V.W.3    Alpar, H.O.4
  • 216
    • 5044235051 scopus 로고    scopus 로고
    • Poly(ortho ester)-From concept to reality
    • J. Heller and J. Barr, Poly(ortho ester)-From concept to reality. Biomacromolecules 5, 1625 (2004).
    • (2004) Biomacromolecules , vol.5 , pp. 1625
    • Heller, J.1    Barr, J.2
  • 217
    • 51649102028 scopus 로고    scopus 로고
    • Recent developments in cyclic acetal biomaterials for tissue engineering applications
    • E. E. Falco, M. Patel, and J. P. Fisher, Recent developments in cyclic acetal biomaterials for tissue engineering applications. Pharmaceut. Res. 25, 2348 (2008).
    • (2008) Pharmaceut. Res. , vol.25 , pp. 2348
    • Falco, E.E.1    Patel, M.2    Fisher, J.P.3
  • 220
    • 0036971305 scopus 로고    scopus 로고
    • Effect of mammalian cell culture medium on the gelation properties of Pluronic F127
    • J. E. Matthew, Y. L. Nazario, S. C. Roberts, and S. R. Bhatia, Effect of mammalian cell culture medium on the gelation properties of Pluronic F127. Biomaterials 23, 4615 (2002).
    • (2002) Biomaterials , vol.23 , pp. 4615
    • Matthew, J.E.1    Nazario, Y.L.2    Roberts, S.C.3    Bhatia, S.R.4
  • 221
    • 84858752288 scopus 로고    scopus 로고
    • Injectable self-assembled block copolymers for sustained gene and drug codelivery: An in vitro study
    • B. Zhang, F. Jia, M. Q. Fleming, and S. K. Mallapragada, Injectable self-assembled block copolymers for sustained gene and drug codelivery: An in vitro study. Int. J. Pharm. 427, 88 (2012).
    • (2012) Int. J. Pharm. , vol.427 , pp. 88
    • Zhang, B.1    Jia, F.2    Fleming, M.Q.3    Mallapragada, S.K.4
  • 222
    • 70349633416 scopus 로고    scopus 로고
    • Evaluation of polyanhydride microspheres for basal insulin delivery: Effect of copolymer composition and zinc salt on encapsulation, in vitro release, stability, in vivo adsorption and bioactivity in diabetic rats
    • C. Manoharan and J. Singh, Evaluation of polyanhydride microspheres for basal insulin delivery: Effect of copolymer composition and zinc salt on encapsulation, in vitro release, stability, in vivo adsorption and bioactivity in diabetic rats. J. Pharm. Sci. 98, 4237 (2009).
    • (2009) J. Pharm. Sci. , vol.98 , pp. 4237
    • Manoharan, C.1    Singh, J.2
  • 224
    • 79955014344 scopus 로고    scopus 로고
    • Slicylic acid-derived poly(anhydride-ester) electrospun fibers designed for regenerating the peripheral nervous system
    • J. Griffin, R. Delgado-Rivera, S. Meiners, and K. E. Uhrich, Slicylic acid-derived poly(anhydride-ester) electrospun fibers designed for regenerating the peripheral nervous system. J. Biomed. Mater. Res. A 97, 230 (2011).
    • (2011) J. Biomed. Mater. Res. A , vol.97 , pp. 230
    • Griffin, J.1    Delgado-Rivera, R.2    Meiners, S.3    Uhrich, K.E.4
  • 227
    • 84904070523 scopus 로고    scopus 로고
    • Lung deposition and cellular uptake behavior of pathogen-mimicking nanovaccines in the first 48 hours
    • In press, DOI: 10.1002/adhm.201300525
    • K. A. Ross, S. L. Haughney, L. K. Petersen, P. Boggiatto, M. J. Wannemuehler, and B. Narasimhan, Lung deposition and cellular uptake behavior of pathogen-mimicking nanovaccines in the first 48 hours. Adv. Healthc. Mater. (2014), In press, DOI: 10.1002/adhm.201300525.
    • (2014) Adv. Healthc. Mater.
    • Ross, K.A.1    Haughney, S.L.2    Petersen, L.K.3    Boggiatto, P.4    Wannemuehler, M.J.5    Narasimhan, B.6
  • 229
    • 33644787333 scopus 로고    scopus 로고
    • Single dose vaccine based on biodegradable polyanhydride microspheres can modulate immune response mechanism
    • M. J. Kipper, J. H. Wilson, M. J. Wannemuehler, and B. Narasimhan, Single dose vaccine based on biodegradable polyanhydride microspheres can modulate immune response mechanism. J. Biomed. Mater. Res. A 76, 798 (2006).
    • (2006) J. Biomed. Mater. Res. A , vol.76 , pp. 798
    • Kipper, M.J.1    Wilson, J.H.2    Wannemuehler, M.J.3    Narasimhan, B.4
  • 230
    • 2942627626 scopus 로고    scopus 로고
    • Hydrophobicity: An ancient damageassociated molecular pattern that initiates innate immune responses
    • S. Y. Seong and P. Matzinger, Hydrophobicity: An ancient damageassociated molecular pattern that initiates innate immune responses. Nat. Rev. Immunol. 4, 469 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 469
    • Seong, S.Y.1    Matzinger, P.2
  • 232
    • 84908069924 scopus 로고    scopus 로고
    • Structural and antigenic stability of H5N1 hemagglutinin trimer upon release from polyanhydride nanoparticles
    • In press, DOI: 10.1002/jbm.a.35086
    • K. A. Ross, H. Loyd, W. Wu, L. Huntimer, M. J. Wannemuehler, S. Carpenter, and B. Narasimhan, Structural and antigenic stability of H5N1 hemagglutinin trimer upon release from polyanhydride nanoparticles. J. Biomed. Mater. Res. A (2014), In press, DOI: 10.1002/jbm.a.35086.
    • (2014) J. Biomed. Mater. Res. A
    • Ross, K.A.1    Loyd, H.2    Wu, W.3    Huntimer, L.4    Wannemuehler, M.J.5    Carpenter, S.6    Narasimhan, B.7
  • 234
    • 0035936975 scopus 로고    scopus 로고
    • Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: In vitro characterisation and in vivo evaluation
    • H. M. Redhead, S. S. Davis, and L. Illum, Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: In vitro characterisation and in vivo evaluation. J. Controlled Release 70, 353 (2001).
    • (2001) J. Controlled Release , vol.70 , pp. 353
    • Redhead, H.M.1    Davis, S.S.2    Illum, L.3
  • 235
    • 67349179610 scopus 로고    scopus 로고
    • Nanoparticle-based targeted drug delivery
    • R. Singh and J. W. Lillard, Nanoparticle-based targeted drug delivery. Exp. Mol. Pathol. 86, 215 (2009).
    • (2009) Exp. Mol. Pathol. , vol.86 , pp. 215
    • Singh, R.1    Lillard, J.W.2
  • 236
    • 84871956263 scopus 로고    scopus 로고
    • Biodegradable particles as vaccine delivery systems: Size matters
    • V. B. Joshi, S. M. Geary, and A. K. Salem, Biodegradable particles as vaccine delivery systems: Size matters. AAPS J. 15, 85 (2013).
    • (2013) AAPS J. , vol.15 , pp. 85
    • Joshi, V.B.1    Geary, S.M.2    Salem, A.K.3
  • 237
    • 0031469673 scopus 로고    scopus 로고
    • The mechanism of uptake of biodegradable microparticles in Caco- 2 cells is size dependent
    • M. P. Desai, V. Labhasetwar, E. Walter, R. Levy, and G. L. Amidon, The mechanism of uptake of biodegradable microparticles in Caco- 2 cells is size dependent. Pharm. Res. 14, 1568 (1997).
    • (1997) Pharm. Res. , vol.14 , pp. 1568
    • Desai, M.P.1    Labhasetwar, V.2    Walter, E.3    Levy, R.4    Amidon, G.L.5
  • 238
    • 33750569806 scopus 로고    scopus 로고
    • Review of aerosol transmission of influenza A virus
    • R. Tellier, Review of aerosol transmission of influenza A virus. Emerg. Infect. Dis. 12, 1657 (2006).
    • (2006) Emerg. Infect. Dis. , vol.12 , pp. 1657
    • Tellier, R.1
  • 239
    • 48449102867 scopus 로고    scopus 로고
    • Size dependent interactions of nanoparticles with lung surfactant model systems and the significant impact on surface potential
    • T. Ku, S. Gill, R. Lobenberg, S. Azarmi, W. Roa, and E. J. Prenner, Size dependent interactions of nanoparticles with lung surfactant model systems and the significant impact on surface potential. J. Nanosci. Nanotechnol. 8, 2971 (2008).
    • (2008) J. Nanosci. Nanotechnol. , vol.8 , pp. 2971
    • Ku, T.1    Gill, S.2    Lobenberg, R.3    Azarmi, S.4    Roa, W.5    Prenner, E.J.6
  • 240
    • 0032126044 scopus 로고    scopus 로고
    • Stabilization of substances in circulation
    • C. Monfardini and M. Veronese, Stabilization of substances in circulation. Bioconjug. Chem. 9, 418 (1998).
    • (1998) Bioconjug. Chem. , vol.9 , pp. 418
    • Monfardini, C.1    Veronese, M.2
  • 242
    • 0035848402 scopus 로고    scopus 로고
    • In vitro uptake of polystyrene microspheres: Effect of particle size, cell line and cell density
    • W. Zauner, N. A. Farrow, and A. M. Haines, In vitro uptake of polystyrene microspheres: Effect of particle size, cell line and cell density. J. Controlled Release 71, 39 (2001).
    • (2001) J. Controlled Release , vol.71 , pp. 39
    • Zauner, W.1    Farrow, N.A.2    Haines, A.M.3
  • 243
    • 33847232545 scopus 로고    scopus 로고
    • Type 1 and 2 immunity following vaccination is influenced by nanoparticle size: Formulation of a model vaccine for respiratory syncytial virus
    • P. L. Mottram, D. Leong, B. Crimeen-Irwin, S. Gloster, S. D. Xiang, J. Meanger, R. Ghildyal, N. Vardaxis, and M. Plebanski, Type 1 and 2 immunity following vaccination is influenced by nanoparticle size: Formulation of a model vaccine for respiratory syncytial virus. Mol. Pharm. 4, 73 (2006).
    • (2006) Mol. Pharm. , vol.4 , pp. 73
    • Mottram, P.L.1    Leong, D.2    Crimeen-Irwin, B.3    Gloster, S.4    Xiang, S.D.5    Meanger, J.6    Ghildyal, R.7    Vardaxis, N.8    Plebanski, M.9
  • 244
    • 0034996764 scopus 로고    scopus 로고
    • Long-circulating and target-specific nanoparticles: Theory to practice
    • S. M. Moghimi, A. C. Hunter, and J. C. Murray, Long-circulating and target-specific nanoparticles: Theory to practice. Pharmacol. Rev. 53, 283 (2001).
    • (2001) Pharmacol. Rev. , vol.53 , pp. 283
    • Moghimi, S.M.1    Hunter, A.C.2    Murray, J.C.3
  • 245
    • 0029379535 scopus 로고
    • Mechanisms of splenic clearance of blood cells and particles: Towards development of new splenotropic agents
    • S. M. Moghimi, Mechanisms of splenic clearance of blood cells and particles: Towards development of new splenotropic agents. Adv. Drug Deliv. Rev. 17, 103 (1995).
    • (1995) Adv. Drug Deliv. Rev. , vol.17 , pp. 103
    • Moghimi, S.M.1
  • 246
    • 34547178393 scopus 로고    scopus 로고
    • Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers
    • J. A. Champion, Y. K. Katare, and S. Mitragotri, Particle shape: A new design parameter for micro- and nanoscale drug delivery carriers. J. Control Release 121, 3 (2007).
    • (2007) J. Control Release , vol.121 , pp. 3
    • Champion, J.A.1    Katare, Y.K.2    Mitragotri, S.3
  • 248
    • 77954937488 scopus 로고    scopus 로고
    • Polymer particles that switch shape in response to a stimulus
    • J.-W. Yoo and S. Mitragotri, Polymer particles that switch shape in response to a stimulus. Proc. Natl. Acad. Sci. USA 107, 11205 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 11205
    • Yoo, J.-W.1    Mitragotri, S.2
  • 249
    • 77249104877 scopus 로고    scopus 로고
    • Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles
    • C. He, Y. Hu, L. Yin, C. Tang, and C. Yin, Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials 31, 3657 (2010).
    • (2010) Biomaterials , vol.31 , pp. 3657
    • He, C.1    Hu, Y.2    Yin, L.3    Tang, C.4    Yin, C.5
  • 251
    • 65249104133 scopus 로고    scopus 로고
    • Immunology taught by lung dendritic cells
    • C. Von Garnier and L. P. Nicod, Immunology taught by lung dendritic cells. Swiss Med. Wkly 139, 186 (2009).
    • (2009) Swiss Med. Wkly , vol.139 , pp. 186
    • Von Garnier, C.1    Nicod, L.P.2
  • 254
  • 255
    • 58149177361 scopus 로고    scopus 로고
    • Inhaled liposomes-current strategies and future challenges
    • M. M. Gaspar, U. Bakowsky, and C. Ehrhardt, Inhaled liposomes-current strategies and future challenges. J. Biomed. Nanotechnol. 4, 245 (2008).
    • (2008) J. Biomed. Nanotechnol. , vol.4 , pp. 245
    • Gaspar, M.M.1    Bakowsky, U.2    Ehrhardt, C.3
  • 256
    • 45849102087 scopus 로고    scopus 로고
    • Liposomes as a carrier for pulmonary delivery of peptides and proteins
    • R. Bi and N. Zhang, Liposomes as a carrier for pulmonary delivery of peptides and proteins. J. Biomed. Nanotechol. 3, 332 (2007).
    • (2007) J. Biomed. Nanotechol. , vol.3 , pp. 332
    • Bi, R.1    Zhang, N.2
  • 257
    • 62849109927 scopus 로고    scopus 로고
    • Pharmaceutical aspects of intranasal delivery of vaccines using particulate systems
    • S. Sharma, T. K. S. Mukkur, H. A. E. Benson, and Y. Chen, Pharmaceutical aspects of intranasal delivery of vaccines using particulate systems. J. Pharm. Sci. 98, 812 (2009).
    • (2009) J. Pharm. Sci. , vol.98 , pp. 812
    • Sharma, S.1    Mukkur, T.K.S.2    Benson, H.A.E.3    Chen, Y.4
  • 262
    • 84890965081 scopus 로고    scopus 로고
    • Universal influenza virus vaccines: Need for clinical trials
    • F. Krammer and P. Palese, Universal influenza virus vaccines: Need for clinical trials. Nat. Immunol. 15, 3 (2014).
    • (2014) Nat. Immunol. , vol.15 , pp. 3
    • Krammer, F.1    Palese, P.2
  • 265
    • 0028229934 scopus 로고
    • Heterosubtypic immunity to influenza type A virus in mice. Effector mechanisms and their longevity
    • S. Liang, K. Mozdzanowska, G. Palladino, and W. Gerhard, Heterosubtypic immunity to influenza type A virus in mice. Effector mechanisms and their longevity. J. Immunol. 152, 1653 (1994).
    • (1994) J. Immunol. , vol.152 , pp. 1653
    • Liang, S.1    Mozdzanowska, K.2    Palladino, G.3    Gerhard, W.4
  • 266
    • 77953957400 scopus 로고    scopus 로고
    • Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins
    • J. L. Nayak, K. A. Richards, F. A. Chaves, and A. J. Sant, Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins. Viral Immunol. 23, 169 (2010).
    • (2010) Viral Immunol. , vol.23 , pp. 169
    • Nayak, J.L.1    Richards, K.A.2    Chaves, F.A.3    Sant, A.J.4
  • 268
    • 61349161008 scopus 로고    scopus 로고
    • Migration, maintenance and recall of memory T cells in peripheral tissues
    • D. L. Woodland and J. E. Kohlmeier, Migration, maintenance and recall of memory T cells in peripheral tissues. Nat. Rev. Immunol. 9, 153 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 153
    • Woodland, D.L.1    Kohlmeier, J.E.2
  • 270
    • 27944445029 scopus 로고    scopus 로고
    • Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung
    • G. J. de Bree, E. M. van Leeuwen, T. A. Out, H. M. Jansen, R. E. Jonkers, and R. A. van Lier, Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung. J. Exp. Med. 202, 1433 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 1433
    • De Bree, G.J.1    Van Leeuwen, E.M.2    Out, T.A.3    Jansen, H.M.4    Jonkers, R.E.5    Van Lier, R.A.6
  • 271
    • 46749150361 scopus 로고    scopus 로고
    • The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections
    • J. E. Kohlmeier, S. C. Miller, J. Smith, B. Lu, C. Gerard, T. Cookenham, A. D. Roberts, and D. L. Woodland, The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections. Immunity 29, 101 (2008).
    • (2008) Immunity , vol.29 , pp. 101
    • Kohlmeier, J.E.1    Miller, S.C.2    Smith, J.3    Lu, B.4    Gerard, C.5    Cookenham, T.6    Roberts, A.D.7    Woodland, D.L.8
  • 272
    • 84887515800 scopus 로고    scopus 로고
    • Lung airwaysurveilling CXCR3hi memory CD8+ T cells are critical for protection against influenza A virus
    • B. Slutter, L. L. Pewe, S. M. Kaech, and J. T. Harty, Lung airwaysurveilling CXCR3hi memory CD8+ T cells are critical for protection against influenza A virus. Immunity 39, 939 (2013).
    • (2013) Immunity , vol.39 , pp. 939
    • Slutter, B.1    Pewe, L.L.2    Kaech, S.M.3    Harty, J.T.4
  • 273
    • 77953499055 scopus 로고    scopus 로고
    • Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection
    • T. S. Kim, M. M. Hufford, J. Sun, Y. X. Fu, and T. J. Braciale, Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection. J. Exp. Med. 207, 1161 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1161
    • Kim, T.S.1    Hufford, M.M.2    Sun, J.3    Fu, Y.X.4    Braciale, T.J.5
  • 274
    • 77949518873 scopus 로고    scopus 로고
    • IL-15 transpresentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection
    • J. McGill, N. Van Rooijen, and K. L. Legge, IL-15 transpresentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection. J. Exp. Med. 207, 521 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 521
    • McGill, J.1    Van Rooijen, N.2    Legge, K.L.3
  • 275
    • 46949088340 scopus 로고    scopus 로고
    • Protective influenzaspecific CD8 T cell responses require interactions with dendritic cells in the lungs
    • J. McGill, N. Van Rooijen, and K. L. Legge, Protective influenzaspecific CD8 T cell responses require interactions with dendritic cells in the lungs. J. Exp. Med. 205, 1635 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 1635
    • McGill, J.1    Van Rooijen, N.2    Legge, K.L.3
  • 276
    • 79955970125 scopus 로고    scopus 로고
    • Influenza vaccine responses in older adults
    • J. E. McElhaney, Influenza vaccine responses in older adults. Ageing Res. Rev. 10, 379 (2011).
    • (2011) Ageing Res. Rev. , vol.10 , pp. 379
    • McElhaney, J.E.1
  • 277
    • 33744996006 scopus 로고    scopus 로고
    • Why aging T cells fail: Implications for vaccination
    • L. Haynes and S. L. Swain, Why aging T cells fail: Implications for vaccination. Immunity 24, 663 (2006).
    • (2006) Immunity , vol.24 , pp. 663
    • Haynes, L.1    Swain, S.L.2
  • 280
    • 84866451471 scopus 로고    scopus 로고
    • The aged microenvironment contributes to the age-related functional defencts of CD4 T cells in mice
    • J. S. Lefebvre, A. C. Maue, S. M. Eaton, P. A. Lanthier, M. Tighe, and L. Haynes, The aged microenvironment contributes to the age-related functional defencts of CD4 T cells in mice. Aging Cell 11, 732 (2012).
    • (2012) Aging Cell , vol.11 , pp. 732
    • Lefebvre, J.S.1    Maue, A.C.2    Eaton, S.M.3    Lanthier, P.A.4    Tighe, M.5    Haynes, L.6
  • 281
    • 0031464890 scopus 로고    scopus 로고
    • Immunosenescence and germinal center reaction
    • B. Zheng, S. Han, Y. Takahashi, and G. Kelsoe, Immunosenescence and germinal center reaction. Immunol. Rev. 160, 63 (1997).
    • (1997) Immunol. Rev. , vol.160 , pp. 63
    • Zheng, B.1    Han, S.2    Takahashi, Y.3    Kelsoe, G.4
  • 282
    • 11844275234 scopus 로고    scopus 로고
    • Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses
    • S. M. Eaton, E. M. Burns, K. Kusser, T. D. Randall, and L. Haynes, Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses. J. Exp. Med. 200, 1613 (2004).
    • (2004) J. Exp. Med. , vol.200 , pp. 1613
    • Eaton, S.M.1    Burns, E.M.2    Kusser, K.3    Randall, T.D.4    Haynes, L.5
  • 283
    • 0034254660 scopus 로고    scopus 로고
    • Age-dependent alterations in the assembly of signal transduction complexes at the site of T cell/APC interaction
    • A. Tamir, M. D. Eisenbraun, G. G. Garcia, and R. A. Miller, Age-dependent alterations in the assembly of signal transduction complexes at the site of T cell/APC interaction. J. Immunol. 165, 1243 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 1243
    • Tamir, A.1    Eisenbraun, M.D.2    Garcia, G.G.3    Miller, R.A.4
  • 285
    • 41149170727 scopus 로고    scopus 로고
    • Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
    • E. J. Yager, M. Ahmed, K. Lanzer, T. D. Randall, D. L. Woodland, and M. A. Blackman, Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J. Exp. Med. 205, 711 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 711
    • Yager, E.J.1    Ahmed, M.2    Lanzer, K.3    Randall, T.D.4    Woodland, D.L.5    Blackman, M.A.6
  • 286
    • 68149179573 scopus 로고    scopus 로고
    • Immunosenescence: What does it mean to health outcomes in older adults?
    • J. E. McElhaney and R. B. Effros, Immunosenescence: What does it mean to health outcomes in older adults? Curr. Opinions Immunol. 21, 418 (2009).
    • (2009) Curr. Opinions Immunol. , vol.21 , pp. 418
    • McElhaney, J.E.1    Effros, R.B.2
  • 288
  • 290
    • 2142644403 scopus 로고    scopus 로고
    • Inflammatory cytokines overcome age-related defencts in CD4 T cell responses in vivo
    • L. Haynes, S. M. Eaton, E. M. Burns, M. Rincon, and S. L. Swain, Inflammatory cytokines overcome age-related defencts in CD4 T cell responses in vivo. J. Immunol. 172, 5194 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 5194
    • Haynes, L.1    Eaton, S.M.2    Burns, E.M.3    Rincon, M.4    Swain, S.L.5
  • 292
    • 34249107969 scopus 로고    scopus 로고
    • Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine response in young and older adults
    • D. van Duin, H. G. Allore, S. Mohanty, S. Ginter, F. K. Newman, R. B. Belshe, R. Medzhitov, and A. C. Shaw, Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine response in young and older adults. J. Infect. Dis. 195, 1590 (2007).
    • (2007) J. Infect. Dis. , vol.195 , pp. 1590
    • Van Duin, D.1    Allore, H.G.2    Mohanty, S.3    Ginter, S.4    Newman, F.K.5    Belshe, R.B.6    Medzhitov, R.7    Shaw, A.C.8
  • 293
    • 33847328456 scopus 로고    scopus 로고
    • Nutritional factors and immunological aging
    • B. Lesourd, Nutritional factors and immunological aging. Proc. Nutr. Soc. 65, 319 (2006).
    • (2006) Proc. Nutr. Soc. , vol.65 , pp. 319
    • Lesourd, B.1
  • 294
    • 33745479180 scopus 로고    scopus 로고
    • Antibody response to hepatitis B vaccine in end-stage renal disease patients
    • K. M. Chow, M. C. Law, C. B. Leung, C. C. Szeto, and P. K. Li, Antibody response to hepatitis B vaccine in end-stage renal disease patients. Nephron. Clin. Pract. 103, c89 (2006).
    • (2006) Nephron. Clin. Pract. , vol.103
    • Chow, K.M.1    Law, M.C.2    Leung, C.B.3    Szeto, C.C.4    Li, P.K.5
  • 297
    • 84874923852 scopus 로고    scopus 로고
    • The effect of age and recent influenza vaccination history on the immunogenicity and efficacy of 2009-10 seasonal trivalent inactivated influenza vaccination in children
    • S. Ng, D. K. Ip, V. J. Fang, K. H. Chan, S. S. Chiu, G. M. Leung, J. S. Peiris, and B. J. Cowling, The effect of age and recent influenza vaccination history on the immunogenicity and efficacy of 2009-10 seasonal trivalent inactivated influenza vaccination in children. Plos One 8, e59077 (2013).
    • (2013) Plos One , vol.8
    • Ng, S.1    Ip, D.K.2    Fang, V.J.3    Chan, K.H.4    Chiu, S.S.5    Leung, G.M.6    Peiris, J.S.7    Cowling, B.J.8
  • 300
    • 79955042531 scopus 로고    scopus 로고
    • Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability
    • P. T. Tan, A. M. Khan, and J. T. August, Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability. Hum. Vaccin. 7, 402 (2011).
    • (2011) Hum. Vaccin. , vol.7 , pp. 402
    • Tan, P.T.1    Khan, A.M.2    August, J.T.3
  • 302
    • 84880941158 scopus 로고    scopus 로고
    • Evaluation of the humoral and cellular immune responses elicited by the live attenuated and inactivated influenza vaccines and their roles in heterologous protection in ferrets
    • X. Cheng, J. R. Zengel, A. L. Suguitan Jr, Q. Xu, W. Wang, J. Lin, and H. Jin, Evaluation of the humoral and cellular immune responses elicited by the live attenuated and inactivated influenza vaccines and their roles in heterologous protection in ferrets. J. Infect. Dis. 208, 594 (2013).
    • (2013) J. Infect. Dis. , vol.208 , pp. 594
    • Cheng, X.1    Zengel, J.R.2    Suguitan Jr., A.L.3    Xu, Q.4    Wang, W.5    Lin, J.6    Jin, H.7
  • 303
    • 78650063715 scopus 로고    scopus 로고
    • T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model
    • H. Guo, F. Santiago, K. Lambert, T. Takimoto, and D. J. Topham, T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model. J. Virol. 85, 448 (2011).
    • (2011) J. Virol. , vol.85 , pp. 448
    • Guo, H.1    Santiago, F.2    Lambert, K.3    Takimoto, T.4    Topham, D.J.5
  • 304
    • 84862776821 scopus 로고    scopus 로고
    • The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines
    • J. E. McElhaney, X. Zhou, H. K. Talbot, E. Soethout, R. C. Bleackley, D. J. Granville, and G. Pawelec, The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines. Vaccine 30, 2060 (2012).
    • (2012) Vaccine , vol.30 , pp. 2060
    • McElhaney, J.E.1    Zhou, X.2    Talbot, H.K.3    Soethout, E.4    Bleackley, R.C.5    Granville, D.J.6    Pawelec, G.7
  • 305
    • 84866533018 scopus 로고    scopus 로고
    • Memory CD4+ T cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors
    • T. M. Strutt, K. K. McKinstry, Y. Kuang, L. M. Bradley, and S. L. Swain, Memory CD4+ T cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors. PNAS 109, E2551 (2012).
    • (2012) PNAS , vol.109
    • Strutt, T.M.1    McKinstry, K.K.2    Kuang, Y.3    Bradley, L.M.4    Swain, S.L.5
  • 311
    • 84859830991 scopus 로고    scopus 로고
    • Tailoring the immune response by targeting C-type lectin receptors on alveolar macrophages using "pathogen-like" amphiphilic polyanhydride nanoparticles
    • A. V. Chavez-Santoscoy, R. Roychoudhury, N. L. Pohl, M. J. Wannemuehler, B. Narasimhan, and A. E. Ramer-Tait, Tailoring the immune response by targeting C-type lectin receptors on alveolar macrophages using "pathogen-like" amphiphilic polyanhydride nanoparticles. Biomaterials 33, 4762 (2012).
    • (2012) Biomaterials , vol.33 , pp. 4762
    • Chavez-Santoscoy, A.V.1    Roychoudhury, R.2    Pohl, N.L.3    Wannemuehler, M.J.4    Narasimhan, B.5    Ramer-Tait, A.E.6
  • 312
  • 313
    • 79951527599 scopus 로고    scopus 로고
    • A phase III, randomized, open-label study to assess the tolerability and immunogenicity of an H5N1 influenza vaccine administered to healthy adults with a 1-, 2-, 3-, or 6-week interval between first and second doses
    • J. Beran, I. A. Abdel-Messih, J. Raupachova, L. Hobzova, and E. Fragapane, A phase III, randomized, open-label study to assess the tolerability and immunogenicity of an H5N1 influenza vaccine administered to healthy adults with a 1-, 2-, 3-, or 6-week interval between first and second doses. Clin. Ther. 32, 2186 (2010).
    • (2010) Clin. Ther. , vol.32 , pp. 2186
    • Beran, J.1    Abdel-Messih, I.A.2    Raupachova, J.3    Hobzova, L.4    Fragapane, E.5
  • 316
    • 79955114493 scopus 로고    scopus 로고
    • Combined, concurrent, and sequential administration of seasonal influenza and MF59-adjuvanted A/H5N1 vaccines: A phase II randomized, controlled trial of immunogenicity and safety in healthy adults
    • P. Lopez, Y. Caicedo, A. Sierra, S. Tilman, A. Banzhoff, and R. Clemens, Combined, concurrent, and sequential administration of seasonal influenza and MF59-adjuvanted A/H5N1 vaccines: A phase II randomized, controlled trial of immunogenicity and safety in healthy adults. J. Infect. Dis. 203, 1719 (2011).
    • (2011) J. Infect. Dis. , vol.203 , pp. 1719
    • Lopez, P.1    Caicedo, Y.2    Sierra, A.3    Tilman, S.4    Banzhoff, A.5    Clemens, R.6
  • 320
    • 78449255270 scopus 로고    scopus 로고
    • A heterologous MF59-adjuvanted H5N1 prepandemic influenza booster vaccine induces a robust, cross-reactive immune response in adults and the elderly
    • E. Fragapane, R. Gasparini, F. Schioppa, F. Laghi-Pasini, E. Montomoli, and A. Banzhoff, A heterologous MF59-adjuvanted H5N1 prepandemic influenza booster vaccine induces a robust, cross-reactive immune response in adults and the elderly. Clin. Vaccine Immunol. 17, 1817 (2010).
    • (2010) Clin. Vaccine Immunol. , vol.17 , pp. 1817
    • Fragapane, E.1    Gasparini, R.2    Schioppa, F.3    Laghi-Pasini, F.4    Montomoli, E.5    Banzhoff, A.6
  • 322
    • 40049104319 scopus 로고    scopus 로고
    • Evaluation of the safety and immunogenicity of a booster (third) dose of inactivated subvirion H5N1 influenza vaccine in humans
    • K. M. Zangwill, J. J. Treanor, J. D. Campbell, D. L. Noah, and J. Ryea, Evaluation of the safety and immunogenicity of a booster (third) dose of inactivated subvirion H5N1 influenza vaccine in humans. J. Infect. Dis. 197, 580 (2008).
    • (2008) J. Infect. Dis. , vol.197 , pp. 580
    • Zangwill, K.M.1    Treanor, J.J.2    Campbell, J.D.3    Noah, D.L.4    Ryea, J.5
  • 323
    • 58149344414 scopus 로고    scopus 로고
    • Antibody persistence after 2-dose priming and booster response to a third dose of an inactivated, adjuvanted, whole-virion H5N1 vaccine
    • J. T. Lin, C. G. Li, X. Wang, N. Su, Y. Liu, Y. Z. Qiu, M. Yang, J. T. Chen, H. H. Fang, X. P. Dong, W. D. Yin, and Z. J. Feng, Antibody persistence after 2-dose priming and booster response to a third dose of an inactivated, adjuvanted, whole-virion H5N1 vaccine. J. Infect. Dis. 199, 184 (2009).
    • (2009) J. Infect. Dis. , vol.199 , pp. 184
    • Lin, J.T.1    Li, C.G.2    Wang, X.3    Su, N.4    Liu, Y.5    Qiu, Y.Z.6    Yang, M.7    Chen, J.T.8    Fang, H.H.9    Dong, X.P.10    Yin, W.D.11    Feng, Z.J.12
  • 325
    • 69149086060 scopus 로고    scopus 로고
    • Safety and immunogenicity of multiple and higher doses of an inactivated influenza A/H5N1 vaccine
    • J. H. Beigel, J. Voell, C. Y. Huang, P. D. Burbelo, and H. C. Lane, Safety and immunogenicity of multiple and higher doses of an inactivated influenza A/H5N1 vaccine. J. Infect. Dis. 200, 501 (2009).
    • (2009) J. Infect. Dis. , vol.200 , pp. 501
    • Beigel, J.H.1    Voell, J.2    Huang, C.Y.3    Burbelo, P.D.4    Lane, H.C.5
  • 327
    • 50949099930 scopus 로고    scopus 로고
    • Immune responses of healthy subjects to a single dose of intramuscular inactivated influenza A/Vietnam/1203/2004 (H5N1) vaccine after priming with an antigenic variant
    • N. A. Goji, C. Nolan, H. Hill, M. Wolff, D. L. Noah, T. B. Williams, T. Rowe, and J. J. Treanor, Immune responses of healthy subjects to a single dose of intramuscular inactivated influenza A/Vietnam/1203/2004 (H5N1) vaccine after priming with an antigenic variant. J. Infect. Dis. 198, 635 (2008).
    • (2008) J. Infect. Dis. , vol.198 , pp. 635
    • Goji, N.A.1    Nolan, C.2    Hill, H.3    Wolff, M.4    Noah, D.L.5    Williams, T.B.6    Rowe, T.7    Treanor, J.J.8
  • 329
    • 70350025172 scopus 로고    scopus 로고
    • Single dose vaccination with AS03-adjuvanted H5N1 vaccines in a randomized trial induces strong and broad immune responsiveness to booster vaccination in adults
    • T. F. Schwarz, T. Horacek, M. Knuf, H. G. Damman, F. Roman, M. Drame, P. Gillard, and W. Jilg, Single dose vaccination with AS03-adjuvanted H5N1 vaccines in a randomized trial induces strong and broad immune responsiveness to booster vaccination in adults. Vaccine 27, 6284 (2009).
    • (2009) Vaccine , vol.27 , pp. 6284
    • Schwarz, T.F.1    Horacek, T.2    Knuf, M.3    Damman, H.G.4    Roman, F.5    Drame, M.6    Gillard, P.7    Jilg, W.8
  • 330
    • 79953301948 scopus 로고    scopus 로고
    • Immunogenicity profile of a 3.75μ-g hemagglutinin pandemic rH5N1 split virion AS03A-adjuvanted vaccine in elderly persons: A randomized trial
    • S. Heijmans, M. De Meulemeester, P. Reynders, D. Giet, E. Demanet, P. Y. Devresse, G. Icardi, and M. Drame, Immunogenicity profile of a 3.75μ-g hemagglutinin pandemic rH5N1 split virion AS03A-adjuvanted vaccine in elderly persons: A randomized trial. J. Infect. Dis. 203, 1054 (2011).
    • (2011) J. Infect. Dis. , vol.203 , pp. 1054
    • Heijmans, S.1    De Meulemeester, M.2    Reynders, P.3    Giet, D.4    Demanet, E.5    Devresse, P.Y.6    Icardi, G.7    Drame, M.8
  • 331
    • 80051556779 scopus 로고    scopus 로고
    • Immunological priming induced by a two-dose series of H5N1 influenza antigen, administered alone or in combination with two different formulations of AS03 adjuvant in adults: Results of a randomised single heterologous booster dose study at 15 months
    • G. Risi, L. Frenette, J. M. Langley, P. Li, D. Riff, E. Sheldon, D. W. Vaughn, and L. Fries, Immunological priming induced by a two-dose series of H5N1 influenza antigen, administered alone or in combination with two different formulations of AS03 adjuvant in adults: Results of a randomised single heterologous booster dose study at 15 months. Vaccine 29, 6408 (2011).
    • (2011) Vaccine , vol.29 , pp. 6408
    • Risi, G.1    Frenette, L.2    Langley, J.M.3    Li, P.4    Riff, D.5    Sheldon, E.6    Vaughn, D.W.7    Fries, L.8
  • 334
    • 78650981716 scopus 로고    scopus 로고
    • Preclinical and clinical development of plant-made virus-like particle vaccine against avian H5N1 influenza
    • N. Landry, B. J. Ward, S. Trépanier, E. Montomoli, M. Dargis, G. Lapini, and L. P. Vezina, Preclinical and clinical development of plant-made virus-like particle vaccine against avian H5N1 influenza. PLoS ONE 5, e15559 (2010).
    • (2010) PLoS ONE , vol.5
    • Landry, N.1    Ward, B.J.2    Trépanier, S.3    Montomoli, E.4    Dargis, M.5    Lapini, G.6    Vezina, L.P.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.