The aged microenvironment contributes to the age-related functional defects of CD4 T cells in mice

Aging Cell

Volumn 11, Issue 5, 2012, Pages 732-740

  Lefebvre, Julie S ^a   Maue, Alexander C ^a,b   Eaton, Sheri M ^a   Lanthier, Paula A ^a   Tighe, Michael ^a   Haynes, Laura ^a  

^a TRUDEAU INSTITUTE   (United States)

^b NAVAL MEDICAL RESEARCH CENTER   (United States)

Author keywords

CD4 T cells; Dendritic cells; Homeostatic chemokines; Immune defects; Secondary lymphoid organs; T follicular helper cells

Indexed keywords

CHEMOKINE;

ADOPTIVE TRANSFER; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNODEFICIENCY; CONTROLLED STUDY; CORRELATION ANALYSIS; HELPER CELL; LYMPHOCYTE FUNCTION; MALE; MICROENVIRONMENT; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SPLEEN;

AGING; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL GROWTH PROCESSES; CHEMOKINE CCL21; CHEMOKINE CXCL13; DENDRITIC CELLS; LYMPHOCYTE ACTIVATION; LYMPHOID TISSUE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SPLEEN;

MUS;

EID: 84866451471     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2012.00836.x     Document Type: Article

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