메뉴 건너뛰기




Volumn 9, Issue 4, 1998, Pages 418-450

Stabilization of substances in circulation

Author keywords

[No Author keywords available]

Indexed keywords


EID: 0032126044     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc970184f     Document Type: Review
Times cited : (215)

References (478)
  • 1
    • 0002405110 scopus 로고
    • Soluble synthetic polymers as potential drug carriers
    • Duncan, R., and Kopecek, J. (1984) Soluble synthetic polymers as potential drug carriers. Adv. Polym. Sci. 57, 53-101.
    • (1984) Adv. Polym. Sci. , vol.57 , pp. 53-101
    • Duncan, R.1    Kopecek, J.2
  • 3
    • 0026121186 scopus 로고
    • Therapeutic proteins-A pharmaceutical perspective
    • Goddard, P. (1991) Therapeutic proteins-A pharmaceutical perspective. Adv. Drug Delivery Rev. 6, 103-131.
    • (1991) Adv. Drug Delivery Rev. , vol.6 , pp. 103-131
    • Goddard, P.1
  • 4
    • 0026124772 scopus 로고
    • The therapeutic value of poly(ethylene glycol)-modified proteins
    • Nucci, M. L., Shorr, R., and Abuchoski, A. (1991) The therapeutic value of poly(ethylene glycol)-modified proteins. Adv. Drug Delivery Rev. 6, 133-151.
    • (1991) Adv. Drug Delivery Rev. , vol.6 , pp. 133-151
    • Nucci, M.L.1    Shorr, R.2    Abuchoski, A.3
  • 5
    • 0026118764 scopus 로고
    • Preparation, in vivo properties and proposed clinical use of polyoxyethylene-modified tissue plasminogen activator and streptokinase
    • Pizzo, S. V. (1991) Preparation, in vivo properties and proposed clinical use of polyoxyethylene-modified tissue plasminogen activator and streptokinase. Adv. Drug Delivery Rev. 6, 153-166.
    • (1991) Adv. Drug Delivery Rev. , vol.6 , pp. 153-166
    • Pizzo, S.V.1
  • 6
    • 0026121187 scopus 로고
    • Properties of asparaginase-dextran conjugates
    • Wileman, T. E. (1991) Properties of asparaginase-dextran conjugates. Adv. Drug Delivery Rev. 6, 167-180.
    • (1991) Adv. Drug Delivery Rev. , vol.6 , pp. 167-180
    • Wileman, T.E.1
  • 7
    • 0026118760 scopus 로고
    • SMANCS and polymer conjugated macromolecular drugs: Advantages in cancer chemotherapy
    • Maeda, H. (1991) SMANCS and polymer conjugated macromolecular drugs: advantages in cancer chemotherapy. Adv. Drug Delivery Rev. 6, 181-202.
    • (1991) Adv. Drug Delivery Rev. , vol.6 , pp. 181-202
    • Maeda, H.1
  • 8
    • 0026118928 scopus 로고
    • Suppression of antibody responses by conjugates of antigens and monomethoxypoly(ethylene glycol)
    • Sehon, A. H. (1991) Suppression of antibody responses by conjugates of antigens and monomethoxypoly(ethylene glycol). Adv. Drug Delivery Rev. 6, 203-217.
    • (1991) Adv. Drug Delivery Rev. , vol.6 , pp. 203-217
    • Sehon, A.H.1
  • 9
    • 0026757191 scopus 로고
    • Drug-polymer conjugates: Potential for improved chemotherapy
    • Duncan, R. (1992) Drug-polymer conjugates: potential for improved chemotherapy. Anti-Cancer Drugs 3, 175-210.
    • (1992) Anti-Cancer Drugs , vol.3 , pp. 175-210
    • Duncan, R.1
  • 11
    • 0027253357 scopus 로고
    • The coniugation of proteins with polyethylene glycol and other polymers. Altering properties of proteins to enhance their therapeutic potential
    • Katre, N. V. (1993) The coniugation of proteins with polyethylene glycol and other polymers. Altering properties of proteins to enhance their therapeutic potential. Adv. Drug Delivery Rev. 10, 91-114.
    • (1993) Adv. Drug Delivery Rev. , vol.10 , pp. 91-114
    • Katre, N.V.1
  • 12
    • 0029360545 scopus 로고
    • Chemistry of polyethylene glycol conjugates with biologically active molecules
    • Zalipsky, S. (1995) Chemistry of polyethylene glycol conjugates with biologically active molecules. Adv. Drug Delivery Rev. 16, 157-182.
    • (1995) Adv. Drug Delivery Rev. , vol.16 , pp. 157-182
    • Zalipsky, S.1
  • 13
    • 0027987791 scopus 로고
    • Polymer Conjugates. Pharmacokinetic considerations for design and development
    • Duncan, R., and Spreafico, F. (1994) Polymer Conjugates. Pharmacokinetic considerations for design and development. Clin. Pharmacokinet. 27, 290-306.
    • (1994) Clin. Pharmacokinet. , vol.27 , pp. 290-306
    • Duncan, R.1    Spreafico, F.2
  • 14
    • 0346551010 scopus 로고
    • Polymer conjugates with anticancer activity
    • Putnam, D., and Kopecek, J. (1995) Polymer conjugates with anticancer activity. Adv. Polym. Sci. 122, 55-123.
    • (1995) Adv. Polym. Sci. , vol.122 , pp. 55-123
    • Putnam, D.1    Kopecek, J.2
  • 15
    • 0016622773 scopus 로고
    • Structure and properties of pharmacologically active polymers
    • Ringsdorf, H. (1975) Structure and properties of pharmacologically active polymers. J. Polym. Sci., Polym. Symp. 51, 135-153.
    • (1975) J. Polym. Sci., Polym. Symp. , vol.51 , pp. 135-153
    • Ringsdorf, H.1
  • 16
    • 0017699915 scopus 로고
    • Attachment of carbohydrate to enzymes increases their circulation lifetime
    • Marshall, J. J., Humpreys, J. D., and Abramson, S. L. (1977) Attachment of carbohydrate to enzymes increases their circulation lifetime. FEBS Lett. 83, 249-252.
    • (1977) FEBS Lett. , vol.83 , pp. 249-252
    • Marshall, J.J.1    Humpreys, J.D.2    Abramson, S.L.3
  • 19
    • 0017375281 scopus 로고
    • Enhanced plasma persistence of therapeutic enzymes by coupling to soluble dextran
    • Sherwood, R. F., Baird, J. K., Atkinson, T., Wiblin, C. N., Rutte, D. A., and Ellwood, D. C. (1977) Enhanced plasma persistence of therapeutic enzymes by coupling to soluble dextran. Biochem. J. 164, 461-464.
    • (1977) Biochem. J. , vol.164 , pp. 461-464
    • Sherwood, R.F.1    Baird, J.K.2    Atkinson, T.3    Wiblin, C.N.4    Rutte, D.A.5    Ellwood, D.C.6
  • 20
    • 0022622276 scopus 로고
    • Soluble asparaginase-dextran conjugates show increased circulatory persistence and lowered antigen reactivity
    • Wileman, T. E., Foster, R. L., and Elliott, P. N. C. (1986) Soluble asparaginase-dextran conjugates show increased circulatory persistence and lowered antigen reactivity. J. Pharm. Pharmacol. 38, 264-271.
    • (1986) J. Pharm. Pharmacol. , vol.38 , pp. 264-271
    • Wileman, T.E.1    Foster, R.L.2    Elliott, P.N.C.3
  • 21
    • 0021056212 scopus 로고
    • Potential use of an asparaginase-dextran conjugate in acute lymphoblastic leukemia
    • Wileman, T., Bennet, M., and Lilleyman, J. (1983) Potential use of an asparaginase-dextran conjugate in acute lymphoblastic leukemia. J. Pharm. Pharmacol. 35, 762-765.
    • (1983) J. Pharm. Pharmacol. , vol.35 , pp. 762-765
    • Wileman, T.1    Bennet, M.2    Lilleyman, J.3
  • 22
    • 0017089608 scopus 로고
    • New types of synthetic infusion solutions III. Elimination and retention of poly[N-(2-hydroxypropyl)methacrylamide] in a test organism
    • Sprincl, L., Exner, J., Sterba, O., and Kopecek, J. (1976) New types of synthetic infusion solutions III. Elimination and retention of poly[N-(2-hydroxypropyl)methacrylamide] in a test organism. J. Biomed. Mater. Res. 10, 953-963.
    • (1976) J. Biomed. Mater. Res. , vol.10 , pp. 953-963
    • Sprincl, L.1    Exner, J.2    Sterba, O.3    Kopecek, J.4
  • 23
  • 24
    • 49549170184 scopus 로고
    • Poly[N-(2-hydroxypropyl)methacrylamide] 1. Radical polimerisation and co-polymerisation
    • Kopecek, J., and Bazilova, H. (1973) Poly[N-(2-hydroxypropyl)methacrylamide] 1. Radical polimerisation and co-polymerisation. Eur. Polym. J. 9, 7-14.
    • (1973) Eur. Polym. J. , vol.9 , pp. 7-14
    • Kopecek, J.1    Bazilova, H.2
  • 25
    • 84982421771 scopus 로고
    • Poly[N-(2-hydroxypropyl)methacrylamide] IV. Heterogeneous polimerisation
    • Strohalm, J., and Kopecek, J. (1978) Poly[N-(2-hydroxypropyl)methacrylamide] IV. Heterogeneous polimerisation. Angew. Makromol. Chem. 70, 109-118.
    • (1978) Angew. Makromol. Chem. , vol.70 , pp. 109-118
    • Strohalm, J.1    Kopecek, J.2
  • 26
    • 0000932483 scopus 로고
    • Aminolysis of monomeric and polymeric p-nitrophenyl esters of methacryloylated amino acids
    • Rejmanova, P., Labsky, J., and Kopecek, J. (1977) Aminolysis of monomeric and polymeric p-nitrophenyl esters of methacryloylated amino acids. Makromol. Chem. 178, 2159-2168.
    • (1977) Makromol. Chem. , vol.178 , pp. 2159-2168
    • Rejmanova, P.1    Labsky, J.2    Kopecek, J.3
  • 27
    • 0019218032 scopus 로고
    • Polymers containing enzymatically degradable bonds 5. Hydrophilic polymers degradable by papain
    • Ulbrich, K., Zacharieva, E. I., Obereigner, B., and Kopecek, J. (1980) Polymers containing enzymatically degradable bonds 5. Hydrophilic polymers degradable by papain. Biomaterials 1, 199-204.
    • (1980) Biomaterials , vol.1 , pp. 199-204
    • Ulbrich, K.1    Zacharieva, E.I.2    Obereigner, B.3    Kopecek, J.4
  • 28
  • 29
    • 0024398880 scopus 로고
    • Biocompatibility of N-(2-hydroxypropyl)methacrylamide copolymers containing adriamycin. Immunogenicity, effect on hematopoietic stem cells in bone marrow in vivo and effect of mouse splenocytes and human peripheral blood lymphocytes in vitro
    • Rihova, B., Ulbrich, K., Strohalm, J., Vetvika, V., Bilej, M., Duncan, R., and Kopecek, J. (1989) Biocompatibility of N-(2-hydroxypropyl)methacrylamide copolymers containing adriamycin. Immunogenicity, effect on hematopoietic stem cells in bone marrow in vivo and effect of mouse splenocytes and human peripheral blood lymphocytes in vitro. Biomaterials 10, 335-342.
    • (1989) Biomaterials , vol.10 , pp. 335-342
    • Rihova, B.1    Ulbrich, K.2    Strohalm, J.3    Vetvika, V.4    Bilej, M.5    Duncan, R.6    Kopecek, J.7
  • 30
    • 0025099302 scopus 로고
    • The potential of water-soluble polymeric carriers in targeted and site-specific drug delivery
    • Kopecek, J. (1990) The potential of water-soluble polymeric carriers in targeted and site-specific drug delivery. J. Controlled Release 11, 279-290.
    • (1990) J. Controlled Release , vol.11 , pp. 279-290
    • Kopecek, J.1
  • 31
    • 0029025560 scopus 로고
    • Prolonged blood circulation in rats of nanospheres surface-modified with semitelechelic poly[N-(2-hydroxypropyl)methacrylamide]
    • Kamei, S., and Kopecek, J. (1995) Prolonged blood circulation in rats of nanospheres surface-modified with semitelechelic poly[N-(2-hydroxypropyl)methacrylamide]. Pharm. Res. 12, 663-668.
    • (1995) Pharm. Res. , vol.12 , pp. 663-668
    • Kamei, S.1    Kopecek, J.2
  • 32
    • 0021908189 scopus 로고
    • Conjugation of poly(styrene-co-maleic acid) derivative to the antitumor protein neocarzinostatin: Pronounced improvements in pharmacological properties
    • Maeda, H., Ueda, M., Morinaga, T., and Matsumoto, T. (1985) Conjugation of poly(styrene-co-maleic acid) derivative to the antitumor protein neocarzinostatin: pronounced improvements in pharmacological properties. J. Med. Chem. 28, 455-461.
    • (1985) J. Med. Chem. , vol.28 , pp. 455-461
    • Maeda, H.1    Ueda, M.2    Morinaga, T.3    Matsumoto, T.4
  • 33
    • 0024235612 scopus 로고
    • Protein binding of macromolecular anticancer agent SMANCS: Characterization of poly(styrene-co-maleic acid) derivatives as an albumin binding ligand
    • Kobayashi, A., Oda, T., and Maeda, M. (1988) Protein binding of macromolecular anticancer agent SMANCS: characterization of poly(styrene-co-maleic acid) derivatives as an albumin binding ligand. J. Bioact. Compat. Polym. 3, 319-333.
    • (1988) J. Bioact. Compat. Polym. , vol.3 , pp. 319-333
    • Kobayashi, A.1    Oda, T.2    Maeda, M.3
  • 34
    • 0017174056 scopus 로고
    • Biologically active synthetic polymers
    • Breslow, D. S. (1976) Biologically active synthetic polymers. Pure Appl. Chem. 46, 103-113.
    • (1976) Pure Appl. Chem. , vol.46 , pp. 103-113
    • Breslow, D.S.1
  • 35
    • 0015810738 scopus 로고
    • Divinyl ether maleic anhydride (pyran) copolymer used to demonstrate the effect of molecular weight on biological activity
    • Breslow, D. S., Edwards, E. I., and Newborg, N. R. (1973) Divinyl ether maleic anhydride (pyran) copolymer used to demonstrate the effect of molecular weight on biological activity. Nature 246, 160-162.
    • (1973) Nature , vol.246 , pp. 160-162
    • Breslow, D.S.1    Edwards, E.I.2    Newborg, N.R.3
  • 36
    • 0001741852 scopus 로고
    • Synthesis of antitumor-active conjugates of adriamicyn or daunomicyn with the copolymer of divinyl ether and maleic anhydride
    • Hirano, T., Ohashi, S., Morimoto, K., Tsuda, T., Kobayashi, T., and Tsuksgoshi, S. (1986) Synthesis of antitumor-active conjugates of adriamicyn or daunomicyn with the copolymer of divinyl ether and maleic anhydride. Makromol. Chem. 187, 2815-2824.
    • (1986) Makromol. Chem. , vol.187 , pp. 2815-2824
    • Hirano, T.1    Ohashi, S.2    Morimoto, K.3    Tsuda, T.4    Kobayashi, T.5    Tsuksgoshi, S.6
  • 37
    • 0028347317 scopus 로고
    • Synthesis of the conjugate of superoxide dismutase with the copolymer of divinyl ether and maleic anhydride retaining enzymatic activity
    • Hirano, T., Todoroki, S., Kato, H., Yamamoto, H., Caliceti, P., Veronese, F. M., Maeda, H., and Ohashi, S. (1994) Synthesis of the conjugate of superoxide dismutase with the copolymer of divinyl ether and maleic anhydride retaining enzymatic activity. J. Controlled Release 28, 203-209.
    • (1994) J. Controlled Release , vol.28 , pp. 203-209
    • Hirano, T.1    Todoroki, S.2    Kato, H.3    Yamamoto, H.4    Caliceti, P.5    Veronese, F.M.6    Maeda, H.7    Ohashi, S.8
  • 38
    • 0043110832 scopus 로고
    • Polivinylpyrrolidone as plasma expander: Studies on its excretion, distribution and metabolism
    • 247.24
    • Ravin, H. A., Seligman, A. M., and Fine, J. (1952) Polivinylpyrrolidone as plasma expander: studies on its excretion, distribution and metabolism. N. Engl. J. Med. 247.24, 921-929.
    • (1952) N. Engl. J. Med. , pp. 921-929
    • Ravin, H.A.1    Seligman, A.M.2    Fine, J.3
  • 39
    • 0021587854 scopus 로고
    • Polymers of N-vinylpyrrolidone: Synthesis, characterization and uses
    • 17.1
    • Haaf, A. S., and Straub, F. (1985) Polymers of N-vinylpyrrolidone: synthesis, characterization and uses. Polym. J. 17.1, 143-152.
    • (1985) Polym. J. , pp. 143-152
    • Haaf, A.S.1    Straub, F.2
  • 43
    • 0028518395 scopus 로고
    • Low molecular weight end-functionalized poly(N-vinylpyrrolidinone) for the modification of polypeptide amino groups
    • Sartore L., Ranucci, E., Ferruti, P., Caliceti, P., Schiavon, O., and Veronese, F. M. (1994) Low molecular weight end-functionalized poly(N-vinylpyrrolidinone) for the modification of polypeptide amino groups. J. Bioact. Compat. Polym. 9, 411-427.
    • (1994) J. Bioact. Compat. Polym. , vol.9 , pp. 411-427
    • Sartore, L.1    Ranucci, E.2    Ferruti, P.3    Caliceti, P.4    Schiavon, O.5    Veronese, F.M.6
  • 44
    • 0345174058 scopus 로고
    • Soluble hydrophilic polymers. German Patent 2,309,894
    • Kopececk, J., Bacik, J., and Sprincl, L. (1973) Soluble hydrophilic polymers. German Patent 2,309,894.
    • (1973)
    • Kopececk, J.1    Bacik, J.2    Sprincl, L.3
  • 45
    • 0345174057 scopus 로고
    • Hydrophilic materials for transdermal patches JP 6041,968
    • Nitto Electric Industrial Co., Ltd. (1985) Hydrophilic materials for transdermal patches. JP 6041,968.
    • (1985)
  • 46
    • 0345606162 scopus 로고
    • Transdermal pharmaceutical containing dihydropyridine derivatives. JP 60,166,61
    • Takashi, K., Saburo, O., Shoichi, T., and Keisuke, S. (1985) Transdermal pharmaceutical containing dihydropyridine derivatives. JP 60,166,61.
    • (1985)
    • Takashi, K.1    Saburo, O.2    Shoichi, T.3    Keisuke, S.4
  • 47
    • 0000228851 scopus 로고
    • Synthesis and molecular weight characterization of low molecular weight end-functionalized poly(4-acryloylmorpholine)
    • Ranucci, E., Spagnoli, G., Sartore, L., and Ferruti, P. (1994) Synthesis and molecular weight characterization of low molecular weight end-functionalized poly(4-acryloylmorpholine). Macromol. Chem. Phys. 195, 3469-3479.
    • (1994) Macromol. Chem. Phys. , vol.195 , pp. 3469-3479
    • Ranucci, E.1    Spagnoli, G.2    Sartore, L.3    Ferruti, P.4
  • 49
    • 0003358681 scopus 로고
    • Polyethylene glycol
    • (R. L. Davidson, Ed.) McGraw-Hill, New York
    • Powell, G. M. (1980) Polyethylene glycol. In Handbook of Water Soluble Gums and Resins (R. L. Davidson, Ed.) pp 18-1-18-31, McGraw-Hill, New York.
    • (1980) Handbook of Water Soluble Gums and Resins , pp. 181-1831
    • Powell, G.M.1
  • 50
    • 0000609990 scopus 로고
    • The liquid-phase method for peptide synthesis
    • (E. Gross and J. Meienhofer, Eds.) Academic Press, New York
    • Mutter, M., and Bayer, E. (1979) The liquid-phase method for peptide synthesis. In The Peptides (E. Gross and J. Meienhofer, Eds.) pp 285-332, Academic Press, New York.
    • (1979) The Peptides , pp. 285-332
    • Mutter, M.1    Bayer, E.2
  • 51
    • 0025327991 scopus 로고
    • Immunotherapy with monomethoxypolyethylene glycol modified allergenes
    • Dreborg, S., and Akerblom, E. B. (1990) Immunotherapy with monomethoxypolyethylene glycol modified allergenes. Crit. Rev. Ther. Drug Carrier Syst. 6, 315-365.
    • (1990) Crit. Rev. Ther. Drug Carrier Syst. , vol.6 , pp. 315-365
    • Dreborg, S.1    Akerblom, E.B.2
  • 52
    • 0028337034 scopus 로고
    • Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration in mice
    • Yamaoka, T., Tabata, Y., and Ikada, Y. (1994) Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration in mice. J. Pharm. Sci. 83, 601-606.
    • (1994) J. Pharm. Sci. , vol.83 , pp. 601-606
    • Yamaoka, T.1    Tabata, Y.2    Ikada, Y.3
  • 54
    • 0030944064 scopus 로고    scopus 로고
    • Tumor accumulation of poly(ethylene glycol) with different molecular weights after intravenous injection
    • Murakami, Y., Tabata, Y., and Ikada, Y. (1997) Tumor accumulation of poly(ethylene glycol) with different molecular weights after intravenous injection. Drug Delivery 4, 23-31.
    • (1997) Drug Delivery , vol.4 , pp. 23-31
    • Murakami, Y.1    Tabata, Y.2    Ikada, Y.3
  • 55
    • 0022061938 scopus 로고
    • Preparation of Cibacron Blue F3G-A-polyethylene glycol in large scale for use in affinity partitioning
    • Johansson, G., and Joelsson, M. (1985) Preparation of Cibacron Blue F3G-A-polyethylene glycol in large scale for use in affinity partitioning. Biotechnol. Bioeng. 27, 621-625.
    • (1985) Biotechnol. Bioeng. , vol.27 , pp. 621-625
    • Johansson, G.1    Joelsson, M.2
  • 56
    • 0019401834 scopus 로고
    • Polyoxyethylated cholesterol derivatives: Organic synthesis, cellular uptake and effect on methabolism in cultured skin fibroblasts
    • Khachadurian, A. K., Fung, C. H., Van Es, T., and Davis, F. F. (1981) Polyoxyethylated cholesterol derivatives: organic synthesis, cellular uptake and effect on methabolism in cultured skin fibroblasts. Biochim. Biophys. Acta 665, 434-441.
    • (1981) Biochim. Biophys. Acta , vol.665 , pp. 434-441
    • Khachadurian, A.K.1    Fung, C.H.2    Van Es, T.3    Davis, F.F.4
  • 57
    • 0001039302 scopus 로고
    • Attachment of drugs to polyethylene glycols
    • Zalipsky, S., Gilon, C., and Zilkha, A. (1983) Attachment of drugs to polyethylene glycols. Eur. Polym. J. 19, 1177-1183.
    • (1983) Eur. Polym. J. , vol.19 , pp. 1177-1183
    • Zalipsky, S.1    Gilon, C.2    Zilkha, A.3
  • 58
    • 0019409884 scopus 로고
    • Synthesis and pharmacological evaluation of poly(oxyethylene) derivatives of 4-isobutylphenyl-2-propionic acid (Ibuprofen)
    • Cecchi, R., Rusconi, L., Tanzi, M. C., Danusso, F., and Ferruti, P. (1981) Synthesis and pharmacological evaluation of poly(oxyethylene) derivatives of 4-isobutylphenyl-2-propionic acid (Ibuprofen). J. Med. Chem. 24, 622-625.
    • (1981) J. Med. Chem. , vol.24 , pp. 622-625
    • Cecchi, R.1    Rusconi, L.2    Tanzi, M.C.3    Danusso, F.4    Ferruti, P.5
  • 60
    • 0022586622 scopus 로고
    • Synthesis and antimicrobial properties of new aroyl-acrylic esters of polyethylene glycols
    • Dal Pozzo, A., Acquasaliente, M., Donzelli, G., Delor, F., and Ferruti, P. (1986) Synthesis and antimicrobial properties of new aroyl-acrylic esters of polyethylene glycols. Farmaco 41, 622-629.
    • (1986) Farmaco , vol.41 , pp. 622-629
    • Dal Pozzo, A.1    Acquasaliente, M.2    Donzelli, G.3    Delor, F.4    Ferruti, P.5
  • 62
    • 0022092721 scopus 로고
    • Antiinflammatory polymer-bound steroids for topical applications I. Synthesis and characterization
    • Khue, N. V., and Galin, J. C. (1985) Antiinflammatory polymer-bound steroids for topical applications I. Synthesis and characterization. J. Appl. Polym. Sci. 30, 2761-2778.
    • (1985) J. Appl. Polym. Sci. , vol.30 , pp. 2761-2778
    • Khue, N.V.1    Galin, J.C.2
  • 63
    • 0029265458 scopus 로고
    • Functionalized poly(ethylene glycol) for preparation of biologically relevant conjugates
    • Zalipsky, S. (1995) Functionalized poly(ethylene glycol) for preparation of biologically relevant conjugates. Bioconjugate Chem. 6, 150-165.
    • (1995) Bioconjugate Chem. , vol.6 , pp. 150-165
    • Zalipsky, S.1
  • 64
    • 0029007384 scopus 로고
    • Poly(ethylene glycol) with reactive endgroups: I. Modification of proteins
    • Herman, S., Hooftman, G., and Schacht, E. (1995) Poly(ethylene glycol) with reactive endgroups: I. Modification of proteins. J. Bioact. Compat. Polym. 10, 145-187.
    • (1995) J. Bioact. Compat. Polym. , vol.10 , pp. 145-187
    • Herman, S.1    Hooftman, G.2    Schacht, E.3
  • 65
    • 84982052867 scopus 로고
    • Preparation of technical grade polyethylene glycol (PEG) (Mr 20,000)-N6-(2-aminoethyl)-NADH by a procedure adaptable to large scale synthesis
    • Buckmann, A. F., Morr, M., and Kula, M. R. (1987) Preparation of technical grade polyethylene glycol (PEG) (Mr 20,000)-N6-(2-aminoethyl)-NADH by a procedure adaptable to large scale synthesis. Biotechnol. Appl. Biochem. 9, 258-268.
    • (1987) Biotechnol. Appl. Biochem. , vol.9 , pp. 258-268
    • Buckmann, A.F.1    Morr, M.2    Kula, M.R.3
  • 66
    • 0020389289 scopus 로고
    • Functionalization of soluble polymers 4. Synthesis of dichloro- and di-(4-formylphenyloxyethyl) poly(oxyethylene)
    • Bayer, E., Zheng, H., and Geckeler, K. (1982) Functionalization of soluble polymers 4. Synthesis of dichloro- and di-(4-formylphenyloxyethyl) poly(oxyethylene). Polym. Bull. 8, 585-592.
    • (1982) Polym. Bull. , vol.8 , pp. 585-592
    • Bayer, E.1    Zheng, H.2    Geckeler, K.3
  • 67
    • 0000841304 scopus 로고
    • Functionalization of poly(ethylene glycol) and monomethoxy-poly-(ethylene glycol)
    • Buckmann, A., Morr, M., and Johansson, G. (1981) Functionalization of poly(ethylene glycol) and monomethoxy-poly-(ethylene glycol). Makromol. Chem. 182, 1379-1384.
    • (1981) Makromol. Chem. , vol.182 , pp. 1379-1384
    • Buckmann, A.1    Morr, M.2    Johansson, G.3
  • 68
    • 0001020712 scopus 로고
    • Linear and starshaped hybrid polymers 1. A new method for the conversion of hydroxyl end groups of poly(oxyethylene) and other polyols into amino end groups
    • Ziegast, G., and Pfannemuller, B. (1984) Linear and starshaped hybrid polymers 1. A new method for the conversion of hydroxyl end groups of poly(oxyethylene) and other polyols into amino end groups. Makromol. Chem. Rapid Commun. 5, 363-371.
    • (1984) Makromol. Chem. Rapid Commun. , vol.5 , pp. 363-371
    • Ziegast, G.1    Pfannemuller, B.2
  • 69
    • 0021460241 scopus 로고
    • Preparation and characterization of p-toluene sulfonyl ester and amino derivatives of tri- and poly(ethylene glycol)
    • Swamikannu, A. X., and Litt, M. H. (1984) Preparation and characterization of p-toluene sulfonyl ester and amino derivatives of tri- and poly(ethylene glycol). J. Polym. Sci., Polym. Chem. Ed. 22, 1623-1632.
    • (1984) J. Polym. Sci., Polym. Chem. Ed. , vol.22 , pp. 1623-1632
    • Swamikannu, A.X.1    Litt, M.H.2
  • 70
    • 0013492775 scopus 로고
    • Convenient synthesis of α-tosyl-ω-tosyloxypoly(oxyethylene)
    • De Vos, R. J., and Goethals, E. J. (1985) Convenient synthesis of α-tosyl-ω-tosyloxypoly(oxyethylene). Makromol. Chem. Rapid Commun. 6, 53-56.
    • (1985) Makromol. Chem. Rapid Commun. , vol.6 , pp. 53-56
    • De Vos, R.J.1    Goethals, E.J.2
  • 71
    • 0023487803 scopus 로고
    • ω-dithiasuccinoyl (Dts) amino acids and dipeptides: Application of polyethylene glycol as a carrier for functional purification
    • ω-dithiasuccinoyl (Dts) amino acids and dipeptides: Application of polyethylene glycol as a carrier for functional purification. Int. J. Pept. Protein Res. 30, 740-783.
    • (1987) Int. J. Pept. Protein Res. , vol.30 , pp. 740-783
    • Zalipsky, S.1    Albericio, F.2    Slomczynska, U.3    Barany, G.4
  • 73
    • 0347005967 scopus 로고
    • New, easily removable poly(ethylene glycol) supports for the liquid-phase method of peptide synthesis
    • Pillai, V. N. R., Mutter, M., Bayer, E., and Gatfield, I. (1980) New, easily removable poly(ethylene glycol) supports for the liquid-phase method of peptide synthesis. J. Org. Chem. 45, 5364-5370.
    • (1980) J. Org. Chem. , vol.45 , pp. 5364-5370
    • Pillai, V.N.R.1    Mutter, M.2    Bayer, E.3    Gatfield, I.4
  • 74
    • 0345174052 scopus 로고
    • Polyethylene glycol derivatives, modified peptides and production thereof. Eur. Pat. Appl. 0340741
    • Sano, A., Maeda, H., Kai, Y., and Ono, K. (1989) Polyethylene glycol derivatives, modified peptides and production thereof. Eur. Pat. Appl. 0340741.
    • (1989)
    • Sano, A.1    Maeda, H.2    Kai, Y.3    Ono, K.4
  • 75
    • 0003260573 scopus 로고
    • New polyethylene glycol for biomedical applications
    • (S. W. Shalaby, C. L. McCormic, and G. B. Butler, Eds.) ACS Symposium Series, American Chemical Society, Washington, DC
    • Harris, J. M., Dust, J. M., McGill, A., Harris, P. A., Edgel, M. J., Herrati, R. S., Karr, L. J., and Donnelly, D. L. (1991) New polyethylene glycol for biomedical applications. In Water-Soluble Polymers (S. W. Shalaby, C. L. McCormic, and G. B. Butler, Eds.) pp 418-429, ACS Symposium Series, American Chemical Society, Washington, DC.
    • (1991) Water-Soluble Polymers , pp. 418-429
    • Harris, J.M.1    Dust, J.M.2    McGill, A.3    Harris, P.A.4    Edgel, M.J.5    Herrati, R.S.6    Karr, L.J.7    Donnelly, D.L.8
  • 76
    • 0021300923 scopus 로고
    • Immobilization of ligands with organic sulfonyl chlorides
    • Nillsson, K., and Mosbach, K. (1984) Immobilization of ligands with organic sulfonyl chlorides. Methods Enzymol. 104, 56-69.
    • (1984) Methods Enzymol. , vol.104 , pp. 56-69
    • Nillsson, K.1    Mosbach, K.2
  • 77
    • 0025360360 scopus 로고
    • Coupling of poly(ethylene glycol) to albumin under very mild conditions by activation with tresyl chloride: Characterization of the conjugate by partitioning in aqueous two-phase systems
    • Delgado, C., Patel, J. N., Francis, G. E., and Fisher, D. (1990) Coupling of poly(ethylene glycol) to albumin under very mild conditions by activation with tresyl chloride: characterization of the conjugate by partitioning in aqueous two-phase systems. Biotechnol. Appl. Biochem. 12, 119-128.
    • (1990) Biotechnol. Appl. Biochem. , vol.12 , pp. 119-128
    • Delgado, C.1    Patel, J.N.2    Francis, G.E.3    Fisher, D.4
  • 78
    • 0027096963 scopus 로고
    • Polyethylene glycol modification of granulocyte-macrophage colony stimulating factor (GM-CSF) enhances neutrophil priming activity but not colony stimulating activity
    • Knusli, C., Delgado, C., Malik, F., Domine, M., Tejedor, C., Irvine, A. E., Fisher, D., and Francis, G. E. (1992) Polyethylene glycol modification of granulocyte-macrophage colony stimulating factor (GM-CSF) enhances neutrophil priming activity but not colony stimulating activity. Br. J. Haematol. 82, 654-663.
    • (1992) Br. J. Haematol. , vol.82 , pp. 654-663
    • Knusli, C.1    Delgado, C.2    Malik, F.3    Domine, M.4    Tejedor, C.5    Irvine, A.E.6    Fisher, D.7    Francis, G.E.8
  • 79
    • 0024558259 scopus 로고
    • Effects of coupling chemistry on the activity of poly(ethylene glycol)-modified alkaline phosphatase
    • Yoshinga, K., and Harris, J. M. (1989) Effects of coupling chemistry on the activity of poly(ethylene glycol)-modified alkaline phosphatase. J. Bioact. Compat. Polym. 4, 17-24.
    • (1989) J. Bioact. Compat. Polym. , vol.4 , pp. 17-24
    • Yoshinga, K.1    Harris, J.M.2
  • 80
    • 0000992727 scopus 로고
    • End-group modification of α-hydro-ω-methoxypoly-(oxyethylene), 2: Facile methods for the introduction of an α-amino end-group
    • Loccufier, J., Crommen, J., Vandorpe, J., and Schacht, E. (1991) End-group modification of α-hydro-ω-methoxypoly-(oxyethylene), 2: Facile methods for the introduction of an α-amino end-group. Makromol. Chem. Rapid Commun. 12, 159-165.
    • (1991) Makromol. Chem. Rapid Commun. , vol.12 , pp. 159-165
    • Loccufier, J.1    Crommen, J.2    Vandorpe, J.3    Schacht, E.4
  • 81
    • 0001314198 scopus 로고
    • Synthesis and characterization of a polyoxyethylene derivative for the affinity labeling of human hemoglobin
    • Leonard, M., and Dellacherie, E. (1988) Synthesis and characterization of a polyoxyethylene derivative for the affinity labeling of human hemoglobin. Makromol. Chem. 189, 1809-1817.
    • (1988) Makromol. Chem. , vol.189 , pp. 1809-1817
    • Leonard, M.1    Dellacherie, E.2
  • 82
    • 0028458901 scopus 로고
    • Preparation and applications of polyethylene glycolpolystyrene graft resin supports for solid-phase peptide synthesis
    • Zalipsky, S., Chang, J. L., Albericio, F., and Barany, G. (1994) Preparation and applications of polyethylene glycolpolystyrene graft resin supports for solid-phase peptide synthesis. React. Polym. 22, 243-258.
    • (1994) React. Polym. , vol.22 , pp. 243-258
    • Zalipsky, S.1    Chang, J.L.2    Albericio, F.3    Barany, G.4
  • 83
    • 0006349340 scopus 로고
    • Organic synthesis using enzymes in two-phase aqueous ternary systems
    • Pollak, A., and Witeside, G. M. (1976) Organic synthesis using enzymes in two-phase aqueous ternary systems. J. Am. Chem. Soc. 98, 289-291.
    • (1976) J. Am. Chem. Soc. , vol.98 , pp. 289-291
    • Pollak, A.1    Witeside, G.M.2
  • 84
    • 0000313657 scopus 로고
    • Immobilized aminotransferases for amino acid production
    • Rozzell, D. (1987) Immobilized aminotransferases for amino acid production. Methods Enzymol. 136, 479-497.
    • (1987) Methods Enzymol. , vol.136 , pp. 479-497
    • Rozzell, D.1
  • 85
    • 0004638687 scopus 로고
    • Synthesis of ATP-polyethylene glycol and ATP-dextran and their use in the purification of phosphoglycerate kinase from spinach chloroplasts using affinity partitioning
    • Persson, L. O., and Olde, B. (1988) Synthesis of ATP-polyethylene glycol and ATP-dextran and their use in the purification of phosphoglycerate kinase from spinach chloroplasts using affinity partitioning. J. Chromatogr. 457, 183-193.
    • (1988) J. Chromatogr. , vol.457 , pp. 183-193
    • Persson, L.O.1    Olde, B.2
  • 87
    • 0346540565 scopus 로고    scopus 로고
    • Hydrazide derivatives of poly(ethylene glycol) and their bioconjugates
    • (J. M. Harris and S. Zalipsky, Eds.) American Chemical Society, Washington, DC
    • Zalipsky, S., and Menon-Rudolph, S. (1997) Hydrazide derivatives of poly(ethylene glycol) and their bioconjugates. In Poly(ethylene glycol): Chemistry and Biological Applications (J. M. Harris and S. Zalipsky, Eds.) pp 318-341, American Chemical Society, Washington, DC.
    • (1997) Poly(ethylene Glycol): Chemistry and Biological Applications , pp. 318-341
    • Zalipsky, S.1    Menon-Rudolph, S.2
  • 88
    • 0001061374 scopus 로고
    • Chemische Synthese verzweigter Polysaccharide, 5: Kopplung von Oligosacchariden und Amilose an verschiedene Trager durch Hydrazonbindung
    • Andresz, H., Richter, G. C., and Pfannemuller, B. (1978) Chemische Synthese verzweigter Polysaccharide, 5: Kopplung von Oligosacchariden und Amilose an verschiedene Trager durch Hydrazonbindung. (Chemical synthesis of branched polysaccharides, 5. Coupling of oligosaccharides and amylose to various carriers by hydrazone linkage). Makromol. Chem. 179, 301-312.
    • (1978) Makromol. Chem. , vol.179 , pp. 301-312
    • Andresz, H.1    Richter, G.C.2    Pfannemuller, B.3
  • 89
    • 0028295678 scopus 로고
    • Antibodies as targeting moieties: Affinity measurements, conjugation chemistry, and applications in immunoliposomes
    • Herron, J. N., Gentry, C. A., Davies, S. S., and Lin, J. N. (1994) Antibodies as targeting moieties: affinity measurements, conjugation chemistry, and applications in immunoliposomes. J. Controlled Release 28, 155-166.
    • (1994) J. Controlled Release , vol.28 , pp. 155-166
    • Herron, J.N.1    Gentry, C.A.2    Davies, S.S.3    Lin, J.N.4
  • 91
    • 0345606157 scopus 로고
    • Effects of poly(ethylene glycol)-bound alcohols and amines on the partition of albumins and thylakoid membranes in an aqueous two-phase system
    • Johansson, G. (1986) Effects of poly(ethylene glycol)-bound alcohols and amines on the partition of albumins and thylakoid membranes in an aqueous two-phase system. J. Chromatogr. 368, 309-317.
    • (1986) J. Chromatogr. , vol.368 , pp. 309-317
    • Johansson, G.1
  • 92
    • 0025360498 scopus 로고
    • Facile synthesis of α-hydroxy-ω-carboxymethylpolyethylene oxide
    • Zalipsky, S., and Barany, G. (1990) Facile synthesis of α-hydroxy-ω-carboxymethylpolyethylene oxide. J. Bioact. Compat. Polym. 5, 227-231.
    • (1990) J. Bioact. Compat. Polym. , vol.5 , pp. 227-231
    • Zalipsky, S.1    Barany, G.2
  • 93
    • 33845559077 scopus 로고
    • Peptide synthesis in water and the use of immobilized carboxypeptidase Y for deprotection
    • Royer, G., and Anantharmaiah, G. M. (1979) Peptide synthesis in water and the use of immobilized carboxypeptidase Y for deprotection. J. Am. Chem. Soc. 101, 3394-3396.
    • (1979) J. Am. Chem. Soc. , vol.101 , pp. 3394-3396
    • Royer, G.1    Anantharmaiah, G.M.2
  • 94
    • 0019084269 scopus 로고
    • Functionalization of soluble polymers 3. Preparation of carboxy-telechelic polymers
    • Geckeler, K., and Bayer, E. (1980) Functionalization of soluble polymers 3. Preparation of carboxy-telechelic polymers. Polym. Bull. 3, 347-352.
    • (1980) Polym. Bull. , vol.3 , pp. 347-352
    • Geckeler, K.1    Bayer, E.2
  • 95
    • 0042113364 scopus 로고
    • Peptides flanked by two polymers chains, 1. Synthesis of glycyl-L-tryptophylglycine substituted by poly(ethylene oxide) at both the carboxy and amino end groups
    • Joppich, M., and Luisi, P. L. (1979) Peptides flanked by two polymers chains, 1. Synthesis of glycyl-L-tryptophylglycine substituted by poly(ethylene oxide) at both the carboxy and amino end groups. Makromol. Chem. 180, 1381-1384.
    • (1979) Makromol. Chem. , vol.180 , pp. 1381-1384
    • Joppich, M.1    Luisi, P.L.2
  • 96
    • 0001185868 scopus 로고
    • Succinic half-esters of poly(ethylene glycol)s and their benzotriazole and imidazole derivatives as oligomeric drug-binding matrices
    • Ferruti, P., Tanzi, M. C., Rusconi, L., and Cecchi, R. (1981) Succinic half-esters of poly(ethylene glycol)s and their benzotriazole and imidazole derivatives as oligomeric drug-binding matrices. Makromol. Chem. 182, 2183-2192.
    • (1981) Makromol. Chem. , vol.182 , pp. 2183-2192
    • Ferruti, P.1    Tanzi, M.C.2    Rusconi, L.3    Cecchi, R.4
  • 97
    • 0027630475 scopus 로고
    • Synthesis of an end-group functionalized polyethylene glycol-lipid conjugate for preparation of polymer-grafted liposomes
    • Zalipsky, S. (1993) Synthesis of an end-group functionalized polyethylene glycol-lipid conjugate for preparation of polymer-grafted liposomes. Bioconjugate Chem. 4, 296-299.
    • (1993) Bioconjugate Chem. , vol.4 , pp. 296-299
    • Zalipsky, S.1
  • 98
    • 0009503301 scopus 로고
    • Preparation of polyethylene glycol derivatives with two different functional groups at the termini
    • Zalipsky, S., and Barany, G. (1986) Preparation of polyethylene glycol derivatives with two different functional groups at the termini. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 27 (1), 1-2.
    • (1986) Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) , vol.27 , Issue.1 , pp. 1-2
    • Zalipsky, S.1    Barany, G.2
  • 100
    • 0002938723 scopus 로고
    • Use of functionalized polyethylene glycols for modification of polypeptides
    • (J. M. Harris, Ed.) Plenum Press, New York
    • Zalipsky, S., and Lee, C. (1992) Use of functionalized polyethylene glycols for modification of polypeptides. In Poly-(ethylene glycol) Chemistry: Biotechnical and Biomedical Applications (J. M. Harris, Ed.) pp 347-370, Plenum Press, New York.
    • (1992) Poly-(ethylene Glycol) Chemistry: Biotechnical and Biomedical Applications , pp. 347-370
    • Zalipsky, S.1    Lee, C.2
  • 101
    • 0020673838 scopus 로고
    • Coupling of monomethoxypolyethylene glycols to proteins via active esters
    • Boccu', E., Largajolli, R., and Veronese, F. M. (1983) Coupling of monomethoxypolyethylene glycols to proteins via active esters. Z. Naturforsch. 38C, 94-99.
    • (1983) Z. Naturforsch. , vol.38 C , pp. 94-99
    • Boccu', E.1    Largajolli, R.2    Veronese, F.M.3
  • 102
    • 0025341615 scopus 로고
    • Amphipathic polyethylene glycols effectively prolong the circulation time of liposomes
    • Klibanov, A. L., Maruyama, K., Torchilin, V. P., and Huang, L. (1990) Amphipathic polyethylene glycols effectively prolong the circulation time of liposomes. FEBS Lett. 268, 235-237.
    • (1990) FEBS Lett. , vol.268 , pp. 235-237
    • Klibanov, A.L.1    Maruyama, K.2    Torchilin, V.P.3    Huang, L.4
  • 103
    • 0027157735 scopus 로고
    • Specific targeting of poly(ethylene glycol)-modified liposomes: Coupling of homing devices to the ends of the polymeric chains combines effective target binding with long circulation times
    • Blume, G., Cevc, G., Grommelin, M. D. J. A., Bakker-Woudenberg, I. A. J. M., Kluft, C., and Storm, G. (1993) Specific targeting of poly(ethylene glycol)-modified liposomes: coupling of homing devices to the ends of the polymeric chains combines effective target binding with long circulation times. Biochim. Biophys. Acta 1149, 180-184.
    • (1993) Biochim. Biophys. Acta , vol.1149 , pp. 180-184
    • Blume, G.1    Cevc, G.2    Grommelin, M.D.J.A.3    Bakker-Woudenberg, I.A.J.M.4    Kluft, C.5    Storm, G.6
  • 105
    • 0026286167 scopus 로고
    • Accurate evaluation method of the polymer content in monomethoxy(polyethylene glycol) modified proteins based on amino acid analysis
    • Sartore, L., Caliceti, P., Schiavon, O., Monfardini, C., and Veronese, F. M. (1991) Accurate evaluation method of the polymer content in monomethoxy(polyethylene glycol) modified proteins based on amino acid analysis. Appl. Biochem. Biotechnol. 31, 213-222.
    • (1991) Appl. Biochem. Biotechnol. , vol.31 , pp. 213-222
    • Sartore, L.1    Caliceti, P.2    Schiavon, O.3    Monfardini, C.4    Veronese, F.M.5
  • 106
    • 0020607315 scopus 로고
    • A new procedure for the synthesis of polyethylene glycol-protein adducts. Effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin and α2-macroglobulin
    • Beauchamp, C. O., Gonias, S. L., Menapace, D. P., and Pizzo, S. V. (1983) A new procedure for the synthesis of polyethylene glycol-protein adducts. Effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin and α2-macroglobulin. Anal. Biochem. 131, 25-33.
    • (1983) Anal. Biochem. , vol.131 , pp. 25-33
    • Beauchamp, C.O.1    Gonias, S.L.2    Menapace, D.P.3    Pizzo, S.V.4
  • 107
    • 0021891903 scopus 로고
    • Surface modification of proteins: Activation of monomethoxy-polyethylene glycols by phenylchloroformates and modification of ribonuclease and superoxide dismutase
    • Veronese, F. M., Largajolli, R., Boccu', E., Benassi, C. A., and Schiavon, O. (1985) Surface modification of proteins: activation of monomethoxy-polyethylene glycols by phenylchloroformates and modification of ribonuclease and superoxide dismutase. Appl. Biochem. Biotechnol. 11, 141-152.
    • (1985) Appl. Biochem. Biotechnol. , vol.11 , pp. 141-152
    • Veronese, F.M.1    Largajolli, R.2    Boccu', E.3    Benassi, C.A.4    Schiavon, O.5
  • 108
    • 0026812687 scopus 로고
    • Evaluation of a new reagent for covalent attachment of polyethylene glycol to proteins
    • Zalipsky, S., Seltzer, R., and Menon-Rudolph, S. (1992) Evaluation of a new reagent for covalent attachment of polyethylene glycol to proteins. Biotechnol. Appl. Biochem. 15, 100-114.
    • (1992) Biotechnol. Appl. Biochem. , vol.15 , pp. 100-114
    • Zalipsky, S.1    Seltzer, R.2    Menon-Rudolph, S.3
  • 109
    • 0027635874 scopus 로고
    • Enzymatic activity of chymotrypsin and its poly-(ethylene glycol) conjugates toward low and high molecular weight substrates
    • Chiu, H. C., Zalipsky, S., Kopeckova, P., and Kopecek, J. (1993) Enzymatic activity of chymotrypsin and its poly-(ethylene glycol) conjugates toward low and high molecular weight substrates. Bioconjugate Chem. 4, 290-295.
    • (1993) Bioconjugate Chem. , vol.4 , pp. 290-295
    • Chiu, H.C.1    Zalipsky, S.2    Kopeckova, P.3    Kopecek, J.4
  • 110
    • 0344311610 scopus 로고
    • Succinimidyl carbonates of polyethylene glycol: Useful reactive polymers for preparation of protein conjugates
    • (R. L. Dunn and R. M. Ottenbrite, Eds.) American Chemical Society, Washington, DC
    • Zalipsky, S., Seltzer, R., and Nho, K. (1991) Succinimidyl carbonates of polyethylene glycol: useful reactive polymers for preparation of protein conjugates. In Polymeric Drugs and Drug Delivery Systems (R. L. Dunn and R. M. Ottenbrite, Eds.) pp 91-100, American Chemical Society, Washington, DC.
    • (1991) Polymeric Drugs and Drug Delivery Systems , pp. 91-100
    • Zalipsky, S.1    Seltzer, R.2    Nho, K.3
  • 111
    • 0027233533 scopus 로고
    • Refolding and proton pumping activity of a polyethylene glycol-bacterio-rhodopsin water-soluble conjugate
    • Sirokman, G., and Fasman, G. D. (1993) Refolding and proton pumping activity of a polyethylene glycol-bacterio-rhodopsin water-soluble conjugate. Protein Sci. 2, 1161-1170.
    • (1993) Protein Sci. , vol.2 , pp. 1161-1170
    • Sirokman, G.1    Fasman, G.D.2
  • 112
    • 0027259078 scopus 로고
    • Antifibrotic effect of a proline analogue delivered in liposomes to cells in culture
    • Poiani, J. G., Gean, K. F., Fox, J. D., Kohn, J., and Riley, D. J. (1993) Antifibrotic effect of a proline analogue delivered in liposomes to cells in culture. Amino Acids 4, 237-248.
    • (1993) Amino Acids , vol.4 , pp. 237-248
    • Poiani, J.G.1    Gean, K.F.2    Fox, J.D.3    Kohn, J.4    Riley, D.J.5
  • 113
    • 0017701219 scopus 로고
    • Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol
    • Abuchowski, A., Van Es, T., Palczuk, N. C., and Davis, F. F. (1977) Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol. J. Biol. Chem. 252, 3578-3581.
    • (1977) J. Biol. Chem. , vol.252 , pp. 3578-3581
    • Abuchowski, A.1    Van Es, T.2    Palczuk, N.C.3    Davis, F.F.4
  • 114
    • 0017887062 scopus 로고
    • Modification of E. coli L-asparaginase with polyethylene glycol: Disappearance of binding ability to anti-asparaginase serum
    • Ashihara, Y., Kono, T., Yamazaki, S., and Inada, Y. (1978) Modification of E. coli L-asparaginase with polyethylene glycol: Disappearance of binding ability to anti-asparaginase serum. Biochem. Biophys. Res. Commun. 83, 385-391.
    • (1978) Biochem. Biophys. Res. Commun. , vol.83 , pp. 385-391
    • Ashihara, Y.1    Kono, T.2    Yamazaki, S.3    Inada, Y.4
  • 115
    • 0025931920 scopus 로고
    • Selective synthesis of 2,4-bis(O-methoxypolyethylene glycol)-6-chloro-s-triazine as a protein modifier
    • Ono, K., Kai, Y., Maeda, H., Samizo, F., Sakurai, K., Nishimura, H., and Inada, Y. (1991) Selective synthesis of 2,4-bis(O-methoxypolyethylene glycol)-6-chloro-s-triazine as a protein modifier. J. Biomater. Sci., Polym. Ed. 2, 61-65.
    • (1991) J. Biomater. Sci., Polym. Ed. , vol.2 , pp. 61-65
    • Ono, K.1    Kai, Y.2    Maeda, H.3    Samizo, F.4    Sakurai, K.5    Nishimura, H.6    Inada, Y.7
  • 116
    • 0023421981 scopus 로고
    • Synthesis of the aldehyde of oligomeric polyoxyethylene
    • Paley, M. S., and Harris, J. M. (1987) Synthesis of the aldehyde of oligomeric polyoxyethylene. J. Polym. Sci., Part A: Polym. Chem. 25, 2447-2454.
    • (1987) J. Polym. Sci., Part A: Polym. Chem. , vol.25 , pp. 2447-2454
    • Paley, M.S.1    Harris, J.M.2
  • 118
    • 0002670074 scopus 로고
    • Chemical modification of horseradish peroxidase with ethanal-methoxypolyethylene glycol: Solubility in organic solvents, activity, and properties
    • Wirth, P., Souppe, J., Tritsch, D., and Biellmann, J. F. (1991) Chemical modification of horseradish peroxidase with ethanal-methoxypolyethylene glycol: solubility in organic solvents, activity, and properties. Bioorg. Chem. 19, 133-142.
    • (1991) Bioorg. Chem. , vol.19 , pp. 133-142
    • Wirth, P.1    Souppe, J.2    Tritsch, D.3    Biellmann, J.F.4
  • 120
    • 0022060543 scopus 로고
    • Functionalization of soluble polymers, 6. Preparation and kinetic aspects of linear, hydrophilic aldehydes based on poly-(oxyethylene)
    • Bayer, E., Zheng, H., and Geckeler, K. (1985) Functionalization of soluble polymers, 6. Preparation and kinetic aspects of linear, hydrophilic aldehydes based on poly-(oxyethylene). Polym. Bull. 13, 431-434.
    • (1985) Polym. Bull. , vol.13 , pp. 431-434
    • Bayer, E.1    Zheng, H.2    Geckeler, K.3
  • 121
    • 0344045331 scopus 로고
    • Functionalization of α-hydrogen-ω-methoxypoly(oxyethylene), 1: A new method for the conversion of hydroxyl end groups into aldehyde groups
    • Vandoorne, F., Loccufier, J., and Schacht, E. (1989) Functionalization of α-hydrogen-ω-methoxypoly(oxyethylene), 1: A new method for the conversion of hydroxyl end groups into aldehyde groups. Makromol. Chem. Rapid Commun. 10, 271-275.
    • (1989) Makromol. Chem. Rapid Commun. , vol.10 , pp. 271-275
    • Vandoorne, F.1    Loccufier, J.2    Schacht, E.3
  • 122
    • 0027344774 scopus 로고
    • Copolymers of lysine and polyethylene glycol: A new family of functionalized drug carriers
    • Nathan, A., Zalipsky, S., Erthel, S. I., Agathos, S. N., Yarmusch, M. L., and Kohn, J. (1993) Copolymers of lysine and polyethylene glycol: A new family of functionalized drug carriers. Bioconjugate Chem. 4, 54-62.
    • (1993) Bioconjugate Chem. , vol.4 , pp. 54-62
    • Nathan, A.1    Zalipsky, S.2    Erthel, S.I.3    Agathos, S.N.4    Yarmusch, M.L.5    Kohn, J.6
  • 123
    • 0344743938 scopus 로고
    • Polyethylene oxyde: A ligand for mild hydrophobic interaction chromatography?
    • Mathis, R., Hubert, P., and Dellacherie, E. (1985) Polyethylene oxyde: a ligand for mild hydrophobic interaction chromatography? J. Chromatogr. 347, 291-296.
    • (1985) J. Chromatogr. , vol.347 , pp. 291-296
    • Mathis, R.1    Hubert, P.2    Dellacherie, E.3
  • 125
    • 0018367097 scopus 로고
    • Detergents linked to polysacchrides: Preparation and effects on membranes and cells
    • Pitha, J., Kociolek, K., and Caron, M. G. (1979) Detergents linked to polysacchrides: Preparation and effects on membranes and cells. Eur. J. Biochem. 94, 11-18.
    • (1979) Eur. J. Biochem. , vol.94 , pp. 11-18
    • Pitha, J.1    Kociolek, K.2    Caron, M.G.3
  • 126
    • 0023630881 scopus 로고
    • The preparation and properties of novel reversible polymer-protein conjugates. 2-ω-methoxypolyethylene (5000) glycoxymethylene-3-methylmaleyl conjugates of plasminogen activator
    • Garman, A. J., and Kalindijan, S. B. (1987) The preparation and properties of novel reversible polymer-protein conjugates. 2-ω-methoxypolyethylene (5000) glycoxymethylene-3-methylmaleyl conjugates of plasminogen activator. FEBS Lett. 223, 361-365.
    • (1987) FEBS Lett. , vol.223 , pp. 361-365
    • Garman, A.J.1    Kalindijan, S.B.2
  • 127
    • 0344311609 scopus 로고
    • Chemically modified protein and production thereof. Eur. Pat. Appl. 0236987
    • Ueno, H., and Fujino, M. (1987) Chemically modified protein and production thereof. Eur. Pat. Appl. 0236987.
    • (1987)
    • Ueno, H.1    Fujino, M.2
  • 128
    • 0028237252 scopus 로고
    • Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner
    • Kuan, C. T., Wang, Q. C., and Pastan, I. (1994) Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner. J. Biol. Chem. 269, 7610-7616.
    • (1994) J. Biol. Chem. , vol.269 , pp. 7610-7616
    • Kuan, C.T.1    Wang, Q.C.2    Pastan, I.3
  • 129
    • 0025265384 scopus 로고
    • Site-directed PEGylation of recombinant interleukin-2 at its glycosilation site
    • Goodson, R. J., and Katre, N. V. (1990) Site-directed PEGylation of recombinant interleukin-2 at its glycosilation site. Bio/Technolgy 8, 343-346.
    • (1990) Bio/Technolgy , vol.8 , pp. 343-346
    • Goodson, R.J.1    Katre, N.V.2
  • 130
    • 0030135376 scopus 로고    scopus 로고
    • Preparation and characterization of poly-(ethylene glycol) vinyl sulfone
    • Morpurgo, M., Veronese, F. M., Kachensky, D., and Harris, J. M. (1996) Preparation and characterization of poly-(ethylene glycol) vinyl sulfone. Bioconjugate Chem. 7, 363-368.
    • (1996) Bioconjugate Chem. , vol.7 , pp. 363-368
    • Morpurgo, M.1    Veronese, F.M.2    Kachensky, D.3    Harris, J.M.4
  • 131
    • 0002348547 scopus 로고
    • Chemical modification and cleavage of proteins and chemical strategy in immunochemical studies of proteins
    • (M. Z. Atassi, Ed.) Plenum Press, New York
    • Atassi, M. Z. (1977) Chemical modification and cleavage of proteins and chemical strategy in immunochemical studies of proteins. In Immunochemistry of Proteins (M. Z. Atassi, Ed.) pp 1-161, Plenum Press, New York.
    • (1977) Immunochemistry of Proteins , pp. 1-161
    • Atassi, M.Z.1
  • 132
    • 0642346098 scopus 로고
    • The kinetics of the attachment of polymer chains to reactive latex particles and the resulting latex stabilization
    • Huang, Y. H., Li, Z. M., and Morawetz, H. (1985) The kinetics of the attachment of polymer chains to reactive latex particles and the resulting latex stabilization. J. Polym. Sci., Polym. Chem. Ed. 23, 795-799.
    • (1985) J. Polym. Sci., Polym. Chem. Ed. , vol.23 , pp. 795-799
    • Huang, Y.H.1    Li, Z.M.2    Morawetz, H.3
  • 134
    • 0026594762 scopus 로고
    • Reduction of immunoreactivity of bovine serum albumin conjugated with polyethylene glycol in relation to its esterase activity
    • Matsushima, A., Sasaki, H., Kodera, Y., and Inada, Y. (1992) Reduction of immunoreactivity of bovine serum albumin conjugated with polyethylene glycol in relation to its esterase activity. Biochem. Int. 26, 485-490.
    • (1992) Biochem. Int. , vol.26 , pp. 485-490
    • Matsushima, A.1    Sasaki, H.2    Kodera, Y.3    Inada, Y.4
  • 136
    • 0026908168 scopus 로고
    • Hydrogels based on water-soluble poly(ether urethane) derived from L-lysine and poly(ethylene glycol)
    • Nathan, A., Bolikal, D., Vyavahare, N., Zalipsky, S., and Kohn, J. (1992) Hydrogels based on water-soluble poly(ether urethane) derived from L-lysine and poly(ethylene glycol). Macromolecules 25, 4476-4484.
    • (1992) Macromolecules , vol.25 , pp. 4476-4484
    • Nathan, A.1    Bolikal, D.2    Vyavahare, N.3    Zalipsky, S.4    Kohn, J.5
  • 140
    • 0028215139 scopus 로고
    • A new water-soluble synthetic polymer, α,β-polyasparthydrazide, as potential plasma expander and drug carrier
    • Giammona, G., Carlisi, B., Cavallaro, G., Pitarresi, G., and Spampinato, S. (1994) A new water-soluble synthetic polymer, α,β-polyasparthydrazide, as potential plasma expander and drug carrier. J. Controlled Release 29, 63-72.
    • (1994) J. Controlled Release , vol.29 , pp. 63-72
    • Giammona, G.1    Carlisi, B.2    Cavallaro, G.3    Pitarresi, G.4    Spampinato, S.5
  • 141
    • 0030271730 scopus 로고    scopus 로고
    • α,β-poly(N-hydroxyethyl)-DL-asparthamide hydrogels as drug delivery devices
    • Pitarresi, G., Tomarchio, V., Cavallaro, G., and Giammona, G. (1996) α,β-poly(N-hydroxyethyl)-DL-asparthamide hydrogels as drug delivery devices. J. Bioact. Compat. Polym. 11, 328-340.
    • (1996) J. Bioact. Compat. Polym. , vol.11 , pp. 328-340
    • Pitarresi, G.1    Tomarchio, V.2    Cavallaro, G.3    Giammona, G.4
  • 143
    • 0347170843 scopus 로고    scopus 로고
    • Poly(ethylene glycol)-grafted polymers as drug carriers
    • (J. M. Harris and S. Zalipsky, Eds.) American Chemical Society, Washington, DC
    • Schacht E. H., and Hoste, K. (1997) Poly(ethylene glycol)-grafted polymers as drug carriers. In Poly(ethylene glycol): Chemistry and Biological Applications (J. M. Harris and S. Zalipsky, Eds.) pp 297-315, American Chemical Society, Washington, DC.
    • (1997) Poly(ethylene Glycol): Chemistry and Biological Applications , pp. 297-315
    • Schacht, E.H.1    Hoste, K.2
  • 144
    • 0347170868 scopus 로고    scopus 로고
    • Covalent and noncovalent adducts of proteins with water-soluble poly(alkylene oxides)
    • (J. M. Harris and S. Zalipsky, Eds.) American Chemical Society, Washington, DC
    • Topchieva, I. N. (1997) Covalent and noncovalent adducts of proteins with water-soluble poly(alkylene oxides). In Poly-(ethylene glycol): Chemistry and Biological Applications (J. M. Harris and S. Zalipsky, Eds.) pp 193-206, American Chemical Society, Washington, DC.
    • (1997) Poly-(ethylene Glycol): Chemistry and Biological Applications , pp. 193-206
    • Topchieva, I.N.1
  • 147
    • 0029873089 scopus 로고    scopus 로고
    • High water content BSA-PEG hydrogels for controlled release device: Evaluation of the drug release properties
    • Gayet, J. C., and Fortier, G. (1996) High water content BSA-PEG hydrogels for controlled release device: evaluation of the drug release properties. J. Controlled Release 38, 177-184.
    • (1996) J. Controlled Release , vol.38 , pp. 177-184
    • Gayet, J.C.1    Fortier, G.2
  • 148
    • 0019296378 scopus 로고
    • Modification of human hemoglobin with polyethylene glycol: A new candidate for blood substitute
    • Ajisaka, K., and Iwashita, Y. (1980) Modification of human hemoglobin with polyethylene glycol: a new candidate for blood substitute. Biochem. Biophys. Res. Commun. 97, 1076-1081.
    • (1980) Biochem. Biophys. Res. Commun. , vol.97 , pp. 1076-1081
    • Ajisaka, K.1    Iwashita, Y.2
  • 149
    • 0020053016 scopus 로고
    • Pharmacokinetic properties of polyethylene glycol derivatized superoxide dismutase
    • Boccu', E., Velo, G. P., and Veronese, F. M. (1982) Pharmacokinetic properties of polyethylene glycol derivatized superoxide dismutase. Pharmacol. Res. Commun. 14, 113-120.
    • (1982) Pharmacol. Res. Commun. , vol.14 , pp. 113-120
    • Boccu', E.1    Velo, G.P.2    Veronese, F.M.3
  • 150
    • 0022003369 scopus 로고
    • A nonantigenic covalent streptokinase-polyethylene glycol complex with plasminogen activator function
    • Rajagopalan, S., Gonias, S. L., and Pizzo, S. V. (1985) A nonantigenic covalent streptokinase-polyethylene glycol complex with plasminogen activator function. J. Clin. Invest. 75, 413-419.
    • (1985) J. Clin. Invest. , vol.75 , pp. 413-419
    • Rajagopalan, S.1    Gonias, S.L.2    Pizzo, S.V.3
  • 152
    • 0024556782 scopus 로고
    • Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. I. Synthesis and characterization
    • Takakura, T., Kanedo, Y., Fujita, T., Hashida, M., Maeda, H., and Sezaki, H. (1989) Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. I. Synthesis and characterization. J. Pharm. Sci. 78, 117-121.
    • (1989) J. Pharm. Sci. , vol.78 , pp. 117-121
    • Takakura, T.1    Kanedo, Y.2    Fujita, T.3    Hashida, M.4    Maeda, H.5    Sezaki, H.6
  • 153
    • 0024509652 scopus 로고
    • Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. II. Biopharmaceutical and pharmacological properties
    • Takakura, T., Fujita, T., Hashida, M., Maeda, H., and Sezaki, H. (1989) Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. II. Biopharmaceutical and pharmacological properties. J. Pharm. Sci. 78, 219-222.
    • (1989) J. Pharm. Sci. , vol.78 , pp. 219-222
    • Takakura, T.1    Fujita, T.2    Hashida, M.3    Maeda, H.4    Sezaki, H.5
  • 154
    • 0026980122 scopus 로고
    • Targeted delivery of human recombinant superoxide dismutase by chemical modification with mono- and polysaccharides derivatives
    • Fujita, T., Nishikawa, M., Tamaki, C., Takakura, Y., Hashida, M., and Sezaki, H. (1992) Targeted delivery of human recombinant superoxide dismutase by chemical modification with mono- and polysaccharides derivatives. J. Pharmacol. Exp. Ther. 263, 971-978.
    • (1992) J. Pharmacol. Exp. Ther. , vol.263 , pp. 971-978
    • Fujita, T.1    Nishikawa, M.2    Tamaki, C.3    Takakura, Y.4    Hashida, M.5    Sezaki, H.6
  • 155
    • 0027179513 scopus 로고
    • Potentiation of in vivo antitumor effects of recombinant interleukin-1α by gelatin conjugation
    • Tabata, Y., Uno, K., Ikada, Y., Kishida, T., and Shigeru, M. (1993) Potentiation of in vivo antitumor effects of recombinant interleukin-1α by gelatin conjugation. Jpn. J. Cancer Res. 84, 681-688.
    • (1993) Jpn. J. Cancer Res. , vol.84 , pp. 681-688
    • Tabata, Y.1    Uno, K.2    Ikada, Y.3    Kishida, T.4    Shigeru, M.5
  • 156
    • 0029928572 scopus 로고    scopus 로고
    • Conjugation of succinylated gelatin to soybean trypsin inhibitor
    • Shin, Y. H., Kojima, Y., Maeda, H., and Otagiri, M. (1996) Conjugation of succinylated gelatin to soybean trypsin inhibitor. J. Bioact. Compat. Polym. 11, 3-16.
    • (1996) J. Bioact. Compat. Polym. , vol.11 , pp. 3-16
    • Shin, Y.H.1    Kojima, Y.2    Maeda, H.3    Otagiri, M.4
  • 157
    • 0018194158 scopus 로고
    • Immunogenicity and antigenicity of soluble cross-linked enzyme/albumin polymers: Advantages for enzyme therapy
    • Remy, M. H., and Poznansly, M. J. (1978) Immunogenicity and antigenicity of soluble cross-linked enzyme/albumin polymers: advantages for enzyme therapy. Lancet 2, 68-70.
    • (1978) Lancet , vol.2 , pp. 68-70
    • Remy, M.H.1    Poznansly, M.J.2
  • 158
    • 0029620486 scopus 로고
    • Prolonged circulation of recombinant human granulocyte-colony stimulating factor by covalent linkage to albumin through a heterobifunctional polyethylene glycol
    • Paige, A. G., Whitcomb, K. L., Liu, J., and Kinstler, O. (1995) Prolonged circulation of recombinant human granulocyte-colony stimulating factor by covalent linkage to albumin through a heterobifunctional polyethylene glycol. Pharmacol. Res. 12, 1883-1888.
    • (1995) Pharmacol. Res. , vol.12 , pp. 1883-1888
    • Paige, A.G.1    Whitcomb, K.L.2    Liu, J.3    Kinstler, O.4
  • 159
    • 0030087823 scopus 로고    scopus 로고
    • Chemical modification of earthworm fibrinolytic enzyme with human serum albumin fragment and characterization of the protease as a therapeutic enzyme
    • Nakajima, N., Ishihara, K., Sugimoto, M., Sumi, H., Mikuni, K., and Hamada, H. (1996) Chemical modification of earthworm fibrinolytic enzyme with human serum albumin fragment and characterization of the protease as a therapeutic enzyme. Biosci., Biotechnol., Biochem. 60, 293-300.
    • (1996) Biosci., Biotechnol., Biochem. , vol.60 , pp. 293-300
    • Nakajima, N.1    Ishihara, K.2    Sugimoto, M.3    Sumi, H.4    Mikuni, K.5    Hamada, H.6
  • 160
    • 0018287715 scopus 로고
    • A lipophilic derivative of neocarzinostatin. A polymer conjugation of antitumor protein antibiotic
    • Maeda, H., Takeshita, J., and Kanamaru, R. (1979) A lipophilic derivative of neocarzinostatin. A polymer conjugation of antitumor protein antibiotic. Int. J. Pept. Protein Res. 14, 81-87.
    • (1979) Int. J. Pept. Protein Res. , vol.14 , pp. 81-87
    • Maeda, H.1    Takeshita, J.2    Kanamaru, R.3
  • 161
    • 0003451102 scopus 로고    scopus 로고
    • Pharmacological uniqueness and clinical effects of neocarzinostatin
    • (H. Maeda, K. Edo, and N. Ishida, Eds.) Springer-Verlag, Tokyo
    • Maeda, H. (1997) Pharmacological uniqueness and clinical effects of neocarzinostatin. In Neocarzinostatin: the past, present, and future of an anticancer drug (H. Maeda, K. Edo, and N. Ishida, Eds.) pp 205-226, Springer-Verlag, Tokyo.
    • (1997) Neocarzinostatin: The Past, Present, and Future of An Anticancer Drug , pp. 205-226
    • Maeda, H.1
  • 162
    • 0023779745 scopus 로고
    • Chemical modification of superoxide dismutase. Extension of plasma half-life of the enzyme through its reversible binding to the circulating albumin
    • Ogino, T., Inoue, M., Ando, Y., Arai, M., Maeda, H., and Morino, Y. (1988) Chemical modification of superoxide dismutase. Extension of plasma half-life of the enzyme through its reversible binding to the circulating albumin. Int. J. Pept. Protein Res. 32, 153-159.
    • (1988) Int. J. Pept. Protein Res. , vol.32 , pp. 153-159
    • Ogino, T.1    Inoue, M.2    Ando, Y.3    Arai, M.4    Maeda, H.5    Morino, Y.6
  • 163
    • 0023764991 scopus 로고
    • Improvement of pharmacological properties of protein drug by tailoring with synthetic polymers
    • Maeda, H., Oda, T., Matsumura, Y., and Kimura, M. (1988) Improvement of pharmacological properties of protein drug by tailoring with synthetic polymers. J. Bioact. Compat. Polym. 3, 27-43.
    • (1988) J. Bioact. Compat. Polym. , vol.3 , pp. 27-43
    • Maeda, H.1    Oda, T.2    Matsumura, Y.3    Kimura, M.4
  • 164
    • 0029926692 scopus 로고    scopus 로고
    • Modification of physico-chemical and biopharmaceutical properties of superoxide dismutase by conjugation to the co-polymer of divinyl ether and maleic anhydride
    • Caliceti, P., Schiavon, O., Hirano, T., Ohashi, S., and Veronese, F. M. (1996) Modification of physico-chemical and biopharmaceutical properties of superoxide dismutase by conjugation to the co-polymer of divinyl ether and maleic anhydride. J. Controlled Release 39, 27-34.
    • (1996) J. Controlled Release , vol.39 , pp. 27-34
    • Caliceti, P.1    Schiavon, O.2    Hirano, T.3    Ohashi, S.4    Veronese, F.M.5
  • 165
    • 0017329561 scopus 로고
    • Stabilization of human beta-D-N-acetylhexosaminidase a towards proteolytic inactivation by coupling it to poly(N-vinylpyrrolidone)
    • Geiger, B., von Specht, B. U., and Arnon, R. (1977) Stabilization of human beta-D-N-acetylhexosaminidase A towards proteolytic inactivation by coupling it to poly(N-vinylpyrrolidone). Eur. J. Biochem. 73, 141-147.
    • (1977) Eur. J. Biochem. , vol.73 , pp. 141-147
    • Geiger, B.1    Von Specht, B.U.2    Arnon, R.3
  • 167
    • 0029007383 scopus 로고
    • Physico-chemical and biological properties of monofunctional hydroxy terminating poly(N-vinylpyrrolidone) conjugated superoxide dismutase
    • Caliceti, P., Schiavon, O., Morpurgo, M., and Veronese, F. M. (1995) Physico-chemical and biological properties of monofunctional hydroxy terminating poly(N-vinylpyrrolidone) conjugated superoxide dismutase. J. Bioact. Compat. Polym. 10, 103-120.
    • (1995) J. Bioact. Compat. Polym. , vol.10 , pp. 103-120
    • Caliceti, P.1    Schiavon, O.2    Morpurgo, M.3    Veronese, F.M.4
  • 169
    • 0023061580 scopus 로고
    • New acrylic polymers for surface modification of enzymes of therapeutic interest and for enzyme immobilization
    • Veronese, F. M., Visco, C., Massarotto, S., Benassi, C. A., and Ferruti, P. (1987) New acrylic polymers for surface modification of enzymes of therapeutic interest and for enzyme immobilization. Ann. N.Y. Acad. Sci. 501, 444-448.
    • (1987) Ann. N.Y. Acad. Sci. , vol.501 , pp. 444-448
    • Veronese, F.M.1    Visco, C.2    Massarotto, S.3    Benassi, C.A.4    Ferruti, P.5
  • 170
    • 0025365377 scopus 로고
    • Catabolism of streptokinase and polyethylene glycol-streptokinase: Evidience for transport of intact forms through the bilary system in the mouse
    • Brucato, F. H., and Pizzo, S. V. (1990) Catabolism of streptokinase and polyethylene glycol-streptokinase: evidience for transport of intact forms through the bilary system in the mouse. Blood 76, 73-79.
    • (1990) Blood , vol.76 , pp. 73-79
    • Brucato, F.H.1    Pizzo, S.V.2
  • 171
    • 0018894595 scopus 로고
    • Preparation of polyethylene glycol: Superoxide dismutase adduct, and an examination of its blood circulatory life and anti-inflammatory activity
    • Pyatak, P. S., Abuchowski, A., and Davis, F. F. (1980) Preparation of polyethylene glycol: superoxide dismutase adduct, and an examination of its blood circulatory life and anti-inflammatory activity. Res. Commun. Chem. Path. Pharmacol. 29, 113-127.
    • (1980) Res. Commun. Chem. Path. Pharmacol. , vol.29 , pp. 113-127
    • Pyatak, P.S.1    Abuchowski, A.2    Davis, F.F.3
  • 173
    • 0021132808 scopus 로고
    • Cancer therapy with chemically modified enzymes. II. The therapeutic effectiveness of arginase and arginase modified by covalent attachment of polyethylene glycol, on the Taper liver tumor and the L5178Y murine leukemia
    • Savoca, K. V., Davis, F. F., van Es, T., McCoy, J. R., and Palczuk, N. C. (1984) Cancer therapy with chemically modified enzymes. II. The therapeutic effectiveness of arginase and arginase modified by covalent attachment of polyethylene glycol, on the Taper liver tumor and the L5178Y murine leukemia. Cancer Biochem. Biophys. 7, 261-268.
    • (1984) Cancer Biochem. Biophys. , vol.7 , pp. 261-268
    • Savoca, K.V.1    Davis, F.F.2    Van Es, T.3    McCoy, J.R.4    Palczuk, N.C.5
  • 174
    • 0023683508 scopus 로고
    • Relationship of effective molecular size to systemic clearance in rats of recombinant interleukine-2 chemically modified with water-soluble polymers
    • Knauf, M. J., Bell, D. P., Hirtzer, P., Luo, Z. P., Young, J. D., and Katre, N. V. (1988) Relationship of effective molecular size to systemic clearance in rats of recombinant interleukine-2 chemically modified with water-soluble polymers. J. Biol. Chem. 263, 15064-15070.
    • (1988) J. Biol. Chem. , vol.263 , pp. 15064-15070
    • Knauf, M.J.1    Bell, D.P.2    Hirtzer, P.3    Luo, Z.P.4    Young, J.D.5    Katre, N.V.6
  • 175
    • 0345174039 scopus 로고
    • Tumor Necrosis Factor-Formulation and preparation. EP 0247860
    • Katre, N. V., Knauf, M., and Thomson, J. (1987) Tumor Necrosis Factor-Formulation and preparation. EP 0247860.
    • (1987)
    • Katre, N.V.1    Knauf, M.2    Thomson, J.3
  • 177
    • 0345174037 scopus 로고
    • Long-Acting Composition. U.S. Patent 4,609,546
    • Hiratani, H. (1986) Long-Acting Composition. U.S. Patent 4,609,546.
    • (1986)
    • Hiratani, H.1
  • 178
    • 0344311597 scopus 로고
    • Conjugation of polymer to colony stimulating factor-1. U.S. Patent 4,847,325
    • Shadle, P. J., Koths, K. E., Moreland, M., and Katre, N. (1989) Conjugation of polymer to colony stimulating factor-1. U.S. Patent 4,847,325.
    • (1989)
    • Shadle, P.J.1    Koths, K.E.2    Moreland, M.3    Katre, N.4
  • 179
    • 0025893378 scopus 로고
    • Pharmacokinetics of recombinant human granulocyte colony stimulating factor conjugated to polyethylene glycol in rats
    • Tanaka, H., Satake-Ishikawa, R., Ishikawa, M., Matsuki, S., and Asano, K. (1991) Pharmacokinetics of recombinant human granulocyte colony stimulating factor conjugated to polyethylene glycol in rats. Cancer Res. 51, 3710-3714.
    • (1991) Cancer Res. , vol.51 , pp. 3710-3714
    • Tanaka, H.1    Satake-Ishikawa, R.2    Ishikawa, M.3    Matsuki, S.4    Asano, K.5
  • 180
    • 0029928302 scopus 로고    scopus 로고
    • Enterai bioavailability of human granulocyte colony stimulating factor conjugated with poly(ethylene glycol)
    • Jensen-Pippo, K. E., Withcomb, K. L., DePrince, R. B., Ralph, L., and Habberfield, A. D. (1996) Enterai bioavailability of human granulocyte colony stimulating factor conjugated with poly(ethylene glycol). Pharmacol Res. 13, 102-107.
    • (1996) Pharmacol Res. , vol.13 , pp. 102-107
    • Jensen-Pippo, K.E.1    Withcomb, K.L.2    DePrince, R.B.3    Ralph, L.4    Habberfield, A.D.5
  • 181
    • 0028343321 scopus 로고
    • Modification of recombinant human granulocyte colony-stimulating factor (rhG-CSF) and its derivative ND 28 with polyethylene glycol
    • Yamasaki, M., Asano, M., Okabe, M., Morimoto, M., and Yokoo, Y. (1994) Modification of recombinant human granulocyte colony-stimulating factor (rhG-CSF) and its derivative ND 28 with polyethylene glycol. J. Biochem. 115, 814-819.
    • (1994) J. Biochem. , vol.115 , pp. 814-819
    • Yamasaki, M.1    Asano, M.2    Okabe, M.3    Morimoto, M.4    Yokoo, Y.5
  • 183
    • 0025151811 scopus 로고
    • Polyethylene glycol modification of Serpins improves therapeutic potential
    • Mast, A. E., Slvensen, G., Brucato, F. H., Schnebli, H. P., and Pizzo, S. V. (1990) Polyethylene glycol modification of Serpins improves therapeutic potential. Biol. Chem. Hoppe-Seyler 371 (Suppl.), 101-109.
    • (1990) Biol. Chem. Hoppe-Seyler , vol.371 , Issue.SUPPL. , pp. 101-109
    • Mast, A.E.1    Slvensen, G.2    Brucato, F.H.3    Schnebli, H.P.4    Pizzo, S.V.5
  • 185
    • 0346540567 scopus 로고    scopus 로고
    • Biochemistry and immunology of poly(ethylene glycol)-modified adenosine deaminase (PEGADA)
    • (J. M. Harris and S. Zalipsky, Eds.) American Chemical Society, Washington, DC
    • Hershfield, M. S. (1997) Biochemistry and immunology of poly(ethylene glycol)-modified adenosine deaminase (PEGADA). In Poly(ethylene glycol): Chemistry and Biological Applications (J. M. Harris and S. Zalipsky, Eds.) pp 145-154, American Chemical Society, Washington, DC.
    • (1997) Poly(ethylene Glycol): Chemistry and Biological Applications , pp. 145-154
    • Hershfield, M.S.1
  • 186
    • 0025019752 scopus 로고
    • The clinical efficacy of poly(ethylene glycol)-modified proteins
    • Fuertges, F., and Abuchowski, A. (1990) The clinical efficacy of poly(ethylene glycol)-modified proteins. J. Controlled Release 11, 139-148.
    • (1990) J. Controlled Release , vol.11 , pp. 139-148
    • Fuertges, F.1    Abuchowski, A.2
  • 188
    • 0019809191 scopus 로고
    • Pharmacology of Escherichia coli L-asparaginase polyethylene glycol adduct
    • Park, Y. K., Abuchowski, A., Davis, S., and Davis, F. F. (1981) Pharmacology of Escherichia coli L-asparaginase polyethylene glycol adduct. Anticancer Res. 1, 373-376.
    • (1981) Anticancer Res. , vol.1 , pp. 373-376
    • Park, Y.K.1    Abuchowski, A.2    Davis, S.3    Davis, F.F.4
  • 190
    • 0018487381 scopus 로고
    • Treatment of L5178Y tumor-bearing BDF1 mice with a nonimmunogenic L-glutaminase-L-asparaginase
    • Abuchowski, A., van Es, T., Palczuk, N. C., McCoy, J. R., and Davis, F. F. (1979) Treatment of L5178Y tumor-bearing BDF1 mice with a nonimmunogenic L-glutaminase-L-asparaginase. Cancer Treat. Rep. 63, 1127-1132.
    • (1979) Cancer Treat. Rep. , vol.63 , pp. 1127-1132
    • Abuchowski, A.1    Van Es, T.2    Palczuk, N.C.3    McCoy, J.R.4    Davis, F.F.5
  • 191
    • 0019996289 scopus 로고
    • Increased antitumor activity of Escherichia coli L-asparaginase by modification with monomethoxypolyethylene glycol
    • Kamisaki, Y., Wada, H., Yagura, T., Nishimura, H., Matsushima, A., and Inada, Y. (1982) Increased antitumor activity of Escherichia coli L-asparaginase by modification with monomethoxypolyethylene glycol. Jpn. J. Cancer Res. 73, 470-474.
    • (1982) Jpn. J. Cancer Res. , vol.73 , pp. 470-474
    • Kamisaki, Y.1    Wada, H.2    Yagura, T.3    Nishimura, H.4    Matsushima, A.5    Inada, Y.6
  • 192
    • 0023766161 scopus 로고
    • Clinical experiences with polyethylene glycolbound E. coli L-asparaginase in patients with multiple recurrences of acute lymphoblastic leukemia
    • Jurgens, H., Schwamborn, D., Korholz, D., Wahn, V., and Gobel, U. (1988) Clinical experiences with polyethylene glycolbound E. coli L-asparaginase in patients with multiple recurrences of acute lymphoblastic leukemia. Klin. Pediatr. 200, 300-306.
    • (1988) Klin. Pediatr. , vol.200 , pp. 300-306
    • Jurgens, H.1    Schwamborn, D.2    Korholz, D.3    Wahn, V.4    Gobel, U.5
  • 193
    • 0029888326 scopus 로고    scopus 로고
    • Improvement of pharmacokinetic, immunological and stability properties of asparaginase by conjugation to linear and branched monomethoxy poly(ethylene glycol)
    • Veronese, F. M., Monfardini, C., Caliceti, P., Schiavon, O., Scrawen, M. D., and Beer, D. (1996) Improvement of pharmacokinetic, immunological and stability properties of asparaginase by conjugation to linear and branched monomethoxy poly(ethylene glycol). J. Controlled Release 40, 199-209.
    • (1996) J. Controlled Release , vol.40 , pp. 199-209
    • Veronese, F.M.1    Monfardini, C.2    Caliceti, P.3    Schiavon, O.4    Scrawen, M.D.5    Beer, D.6
  • 195
    • 0019818287 scopus 로고
    • Immunosuppressive properties and circulating life of Achromobacter glutaminase-asparaginase covalently attached to polyethylene glycol in man
    • Abuchowski, A., Davis, F. F., and Davis, S. (1981) Immunosuppressive properties and circulating life of Achromobacter glutaminase-asparaginase covalently attached to polyethylene glycol in man. Cancer Treat. Rep. 65, 1077-1081.
    • (1981) Cancer Treat. Rep. , vol.65 , pp. 1077-1081
    • Abuchowski, A.1    Davis, F.F.2    Davis, S.3
  • 196
    • 0020409734 scopus 로고
    • Enzyme therapy: Polyethylene glycolglucuronidase conjugates as potential therapeutic agents in acid mucopolysaccharidosis
    • Lisi, P. J., van Es, T., Abuchowski, A., Palczuk, N. C., and Davis, F. F. (1982) Enzyme therapy: polyethylene glycolglucuronidase conjugates as potential therapeutic agents in acid mucopolysaccharidosis. J. Appl. Biochem. 4, 19-33.
    • (1982) J. Appl. Biochem. , vol.4 , pp. 19-33
    • Lisi, P.J.1    Van Es, T.2    Abuchowski, A.3    Palczuk, N.C.4    Davis, F.F.5
  • 197
    • 0019879284 scopus 로고
    • Properties of two urate oxidases modified by the covalent attachment of polyethylene glycol
    • Cheng, R. H. L., Abuchowski, A., van Es, T., Palczuk, N. C., and Davis, F. F. (1981) Properties of two urate oxidases modified by the covalent attachment of polyethylene glycol. Biochim. Biophys. Acta 660, 293-298.
    • (1981) Biochim. Biophys. Acta , vol.660 , pp. 293-298
    • Cheng, R.H.L.1    Abuchowski, A.2    Van Es, T.3    Palczuk, N.C.4    Davis, F.F.5
  • 198
    • 0020365023 scopus 로고
    • Preparation and properties of adducts of streptokinase and streptokinase-plasmin complex with polyethylene glycol and pluronic polyol F38
    • Newmark, J., Abuchowski, A., and Murano, G. (1982) Preparation and properties of adducts of streptokinase and streptokinase-plasmin complex with polyethylene glycol and pluronic polyol F38. J. Appl. Biochem. 4, 185-189.
    • (1982) J. Appl. Biochem. , vol.4 , pp. 185-189
    • Newmark, J.1    Abuchowski, A.2    Murano, G.3
  • 199
    • 0017388651 scopus 로고
    • Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase
    • Abuchowski, A., McCoy, J. R., Palczuk, N. C., van Es, T., and Davis, F. F. (1977) Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase. J. Biol. Chem. 252, 3582-3586.
    • (1977) J. Biol. Chem. , vol.252 , pp. 3582-3586
    • Abuchowski, A.1    McCoy, J.R.2    Palczuk, N.C.3    Van Es, T.4    Davis, F.F.5
  • 200
    • 0018799136 scopus 로고
    • Preparation of a non-immunogenic arginase by the covalent attachment of polyethylene glycol
    • Savoca, K. V., Abuchowski, A., van Es, T., Davis, F. F., and Paklczuk, N. C. (1979) Preparation of a non-immunogenic arginase by the covalent attachment of polyethylene glycol. Biochim. Biophys. Acta 578, 47-53.
    • (1979) Biochim. Biophys. Acta , vol.578 , pp. 47-53
    • Savoca, K.V.1    Abuchowski, A.2    Van Es, T.3    Davis, F.F.4    Paklczuk, N.C.5
  • 201
    • 0018801628 scopus 로고
    • Some properties of polyethylene glycol:phenylalanine ammonia-lyase adducts
    • Wieder, K. J., Palczuk, N. C., van Es, T., and Davis, F. F. (1979) Some properties of polyethylene glycol:phenylalanine ammonia-lyase adducts. J. Biol. Chem. 254, 12579-12587.
    • (1979) J. Biol. Chem. , vol.254 , pp. 12579-12587
    • Wieder, K.J.1    Palczuk, N.C.2    Van Es, T.3    Davis, F.F.4
  • 202
    • 0028472660 scopus 로고
    • Stabilization of L-asparaginase modified with comb-shaped poly(ethylene glycol) derivatives, in vivo and in vitro
    • Kodera, Y., Sekine, T., Yasukohchi, T., Kiriu, Y., Hiroto, M., Matsushima, A., and Inada, Y. (1994) Stabilization of L-asparaginase modified with comb-shaped poly(ethylene glycol) derivatives, in vivo and in vitro. Bioconjugate Chem. 5, 283-286.
    • (1994) Bioconjugate Chem. , vol.5 , pp. 283-286
    • Kodera, Y.1    Sekine, T.2    Yasukohchi, T.3    Kiriu, Y.4    Hiroto, M.5    Matsushima, A.6    Inada, Y.7
  • 203
    • 0027427147 scopus 로고
    • Reduction of immunoreactivity of bovine serum albumin conjugated with comb-shaped polyethylene glycol derivatives
    • Sasaki, H., Ohtake, Y., Matsushima, A., Hiroto, M., Kodera, Y., and Inada, Y. (1993) Reduction of immunoreactivity of bovine serum albumin conjugated with comb-shaped polyethylene glycol derivatives. Biochem. Biophys. Res. Commun. 197, 287-291.
    • (1993) Biochem. Biophys. Res. Commun. , vol.197 , pp. 287-291
    • Sasaki, H.1    Ohtake, Y.2    Matsushima, A.3    Hiroto, M.4    Kodera, Y.5    Inada, Y.6
  • 204
    • 0020053016 scopus 로고
    • Pharmacokinetic properties of polyethylene glycol derivatized superoxide dismutase
    • Boccu', E., Velo, G. P., and Veronese, F. M. (1982) Pharmacokinetic properties of polyethylene glycol derivatized superoxide dismutase. Pharmacol. Res. Commun. 14, 113-120.
    • (1982) Pharmacol. Res. Commun. , vol.14 , pp. 113-120
    • Boccu', E.1    Velo, G.P.2    Veronese, F.M.3
  • 205
    • 84907035691 scopus 로고
    • Preparation of long-acting superoxide dismutase using high molecular weight polyethylene glycol (41,000-72,000 Daltons)
    • Somack, R., Saifer, M. G. P., and Williams, L. D. (1991) Preparation of long-acting superoxide dismutase using high molecular weight polyethylene glycol (41,000-72,000 Daltons). Free Radical Res. Commun. 12-13, 553-562.
    • (1991) Free Radical Res. Commun. , vol.12-13 , pp. 553-562
    • Somack, R.1    Saifer, M.G.P.2    Williams, L.D.3
  • 206
    • 0028610232 scopus 로고
    • Plasma clearance and immunologic properties of long-acting superoxide dismutase prepared using 35,000 to 120,000 dalton poly-ethylene glycol
    • Saifer, M. G., Somack, R., and Williams, L. D. (1994) Plasma clearance and immunologic properties of long-acting superoxide dismutase prepared using 35,000 to 120,000 dalton poly-ethylene glycol. Adv. Exp. Med. Biol. 366, 377-387.
    • (1994) Adv. Exp. Med. Biol. , vol.366 , pp. 377-387
    • Saifer, M.G.1    Somack, R.2    Williams, L.D.3
  • 207
    • 0030894641 scopus 로고    scopus 로고
    • Prolongation of the serum half-life period of superoxide dismutase by poly(ethylene glycol) modification
    • Nakaoka, R., Tabata, Y., Yamaoka, T., and Ikada, Y. (1997) Prolongation of the serum half-life period of superoxide dismutase by poly(ethylene glycol) modification. J. Controlled Release 46, 253-261.
    • (1997) J. Controlled Release , vol.46 , pp. 253-261
    • Nakaoka, R.1    Tabata, Y.2    Yamaoka, T.3    Ikada, Y.4
  • 208
    • 0031193807 scopus 로고    scopus 로고
    • Branched and linear poly(ethylene glycol): Influence of the polymer structure on enzymological, pharmacokinetic, and immunological properties of protein conjugates
    • Veronese, F. M., Caliceti, P., and Schiavon, O. (1997) Branched and linear poly(ethylene glycol): influence of the polymer structure on enzymological, pharmacokinetic, and immunological properties of protein conjugates. J. Bioact. Compat. Polym. 12, 196-207.
    • (1997) J. Bioact. Compat. Polym. , vol.12 , pp. 196-207
    • Veronese, F.M.1    Caliceti, P.2    Schiavon, O.3
  • 209
    • 0347800842 scopus 로고    scopus 로고
    • Conjugation of high-molecular weight poly(ethylene glycol) to cytokines: Granulocyte-macrophage colony-stimulating factors as model substrates
    • (J. M. Harris and S. Zalipsky, Eds.) American Chemical Society, Washington, DC
    • Sherman, M. R., Williams, L. D., Saifer, M. G. P., French, J. A., Kwak, L. W., and Oppenheim, J. J. (1997) Conjugation of high-molecular weight poly(ethylene glycol) to cytokines: granulocyte-macrophage colony-stimulating factors as model substrates. In Poly(ethylene glycol): Chemistry and Biological Applications (J. M. Harris and S. Zalipsky, Eds.) pp 155-169, American Chemical Society, Washington, DC.
    • (1997) Poly(ethylene Glycol): Chemistry and Biological Applications , pp. 155-169
    • Sherman, M.R.1    Williams, L.D.2    Saifer, M.G.P.3    French, J.A.4    Kwak, L.W.5    Oppenheim, J.J.6
  • 211
    • 0020631378 scopus 로고
    • Modification of amino groups in porcine pancreatic elastase with polyethylene glycol in relation to binding activity towards anti-serum and to enzymatic activity
    • Koide, A., and Kobayashi, S. (1983) Modification of amino groups in porcine pancreatic elastase with polyethylene glycol in relation to binding activity towards anti-serum and to enzymatic activity. Biochem. Biophys. Res. Commun. 111, 659-667.
    • (1983) Biochem. Biophys. Res. Commun. , vol.111 , pp. 659-667
    • Koide, A.1    Kobayashi, S.2
  • 212
    • 0018799143 scopus 로고
    • Preparation and properties of polyethylene glycol-trypsin adducts
    • Abuchowski, A., and Davis, F. F. (1979) Preparation and properties of polyethylene glycol-trypsin adducts. Biochim., Biophys. Acta 578, 41-46.
    • (1979) Biochim., Biophys. Acta , vol.578 , pp. 41-46
    • Abuchowski, A.1    Davis, F.F.2
  • 213
    • 0028467278 scopus 로고
    • Preservation of thrombolytic activity of urokinase modified with monomethoxypoly(ethylene glycol)
    • Caliceti, P., Morpurgo, M., Schiavon, O., Monfardini, C., and Veronese, F. M. (1994) Preservation of thrombolytic activity of urokinase modified with monomethoxypoly(ethylene glycol). J. Bioact. Compat. Polym. 9, 252-266.
    • (1994) J. Bioact. Compat. Polym. , vol.9 , pp. 252-266
    • Caliceti, P.1    Morpurgo, M.2    Schiavon, O.3    Monfardini, C.4    Veronese, F.M.5
  • 218
    • 0017874190 scopus 로고
    • Higher antitumor efficacy of daunomycin when linked to dextran: In vivo and in vitro studies
    • Bernstein, A., Huewitz, E., Maron, R., Arnon, R., Sela, M., and Wilchek, M. (1978) Higher antitumor efficacy of daunomycin when linked to dextran: In vivo and in vitro studies. J. Natl. Cancer Inst. 60, 379-384.
    • (1978) J. Natl. Cancer Inst. , vol.60 , pp. 379-384
    • Bernstein, A.1    Huewitz, E.2    Maron, R.3    Arnon, R.4    Sela, M.5    Wilchek, M.6
  • 219
    • 0004833668 scopus 로고
    • Pharmacokinetics of adryamycin-oxidized dextran conjugate (ADMOXD) in experimental animals
    • Fujita, H., Okamoto, M., and Takao, A. (1991) Pharmacokinetics of adryamycin-oxidized dextran conjugate (ADMOXD) in experimental animals (in Japanese). Drug Delivery Syst. 6, 133-138.
    • (1991) Drug Delivery Syst. , vol.6 , pp. 133-138
    • Fujita, H.1    Okamoto, M.2    Takao, A.3
  • 221
    • 0023240259 scopus 로고
    • Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with amonic charge. I. Physicochemical characteristics and in vivo and in vitro antitumor activities
    • Takakura, T., Kitajima, M., Matsumoto, S., Hashida, M., and Sezaki, H. (1987) Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with amonic charge. I. Physicochemical characteristics and in vivo and in vitro antitumor activities. Int. J. Pharm. 37, 135-143.
    • (1987) Int. J. Pharm. , vol.37 , pp. 135-143
    • Takakura, T.1    Kitajima, M.2    Matsumoto, S.3    Hashida, M.4    Sezaki, H.5
  • 222
    • 0030995513 scopus 로고    scopus 로고
    • Synthesis and in vitro stability of macromolecular prodrugs of norfoxacin
    • Coessens, V., Schacht, E. H., and Domurado, D. (1997) Synthesis and in vitro stability of macromolecular prodrugs of norfoxacin. J. Controlled Release 47, 283-291.
    • (1997) J. Controlled Release , vol.47 , pp. 283-291
    • Coessens, V.1    Schacht, E.H.2    Domurado, D.3
  • 223
    • 0028967817 scopus 로고
    • 99mTc-dextran and its accumulation with the inflammed paws of adjuvant-induced arthritic rats
    • 99mTc-dextran and its accumulation with the inflammed paws of adjuvant-induced arthritic rats. Pharmacol. Res. 12, 588-593.
    • (1995) Pharmacol. Res. , vol.12 , pp. 588-593
    • Kellaway, I.W.1    Seale, L.2    Spencer, P.S.J.3
  • 224
    • 0023829660 scopus 로고
    • Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide co-polymers. 2. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia
    • Duncan, R., Kopeckova-Rejmanova, P., Strohalm, J., Hume, I. C., Lloyd, J. B., and Kopecek, J. (1988) Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide co-polymers. 2. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia. Br. J. Cancer 57, 147-156.
    • (1988) Br. J. Cancer , vol.57 , pp. 147-156
    • Duncan, R.1    Kopeckova-Rejmanova, P.2    Strohalm, J.3    Hume, I.C.4    Lloyd, J.B.5    Kopecek, J.6
  • 226
    • 0024469053 scopus 로고
    • Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. 3. Evaluation of adriamycin conjugates against mouse leukaemia L1210 in vivo
    • Duncan, R., Hume, I. C., Kopeckova, P., Ulbrich, K., Strohalm, J., and Kopecek, J. (1989) Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. 3. Evaluation of adriamycin conjugates against mouse leukaemia L1210 in vivo. J. Controlled Release 10, 51-63.
    • (1989) J. Controlled Release , vol.10 , pp. 51-63
    • Duncan, R.1    Hume, I.C.2    Kopeckova, P.3    Ulbrich, K.4    Strohalm, J.5    Kopecek, J.6
  • 227
    • 0027130079 scopus 로고
    • Polymeric drug carriers containing doxorubicin and melanocyte-stimulating hormone: In vitro and in vivo evaluation against murine melanoma
    • O'Hare, K. B., Duncan, R., Strohalm, J., Ulbrich, K., and Kopeckova, P. (1993) Polymeric drug carriers containing doxorubicin and melanocyte-stimulating hormone: in vitro and in vivo evaluation against murine melanoma. J. Drug Targeting 1, 217-229.
    • (1993) J. Drug Targeting , vol.1 , pp. 217-229
    • O'Hare, K.B.1    Duncan, R.2    Strohalm, J.3    Ulbrich, K.4    Kopeckova, P.5
  • 228
    • 0025856232 scopus 로고
    • Macromolecular prodrugs for use in targeted cancer chemotherapy: Melphalan covalently coupled to N-(2-hydroxypropyl)methacrylamide copolymers
    • Duncan, R., Hume, I. C., Yardley, H. J., Flanagan, P. A., Ulbrich, K., Subr, V., and Strohalm, J. (1991) Macromolecular prodrugs for use in targeted cancer chemotherapy: melphalan covalently coupled to N-(2-hydroxypropyl)methacrylamide copolymers. J. Controlled Release 16, 121-136.
    • (1991) J. Controlled Release , vol.16 , pp. 121-136
    • Duncan, R.1    Hume, I.C.2    Yardley, H.J.3    Flanagan, P.A.4    Ulbrich, K.5    Subr, V.6    Strohalm, J.7
  • 229
    • 0009975408 scopus 로고
    • Polymer bound derivatives of sarcolysin and their antitumor activity against mouse and human leukaemia in vitro
    • Ulbrich, K., Zacharieva, E., Kopecek, J., Hume, I. C., and Duncan, R. (1987) Polymer bound derivatives of sarcolysin and their antitumor activity against mouse and human leukaemia in vitro. Makromol. Chem. 188, 2497-2509.
    • (1987) Makromol. Chem. , vol.188 , pp. 2497-2509
    • Ulbrich, K.1    Zacharieva, E.2    Kopecek, J.3    Hume, I.C.4    Duncan, R.5
  • 230
    • 0001095828 scopus 로고
    • Targetable photoactive drugs 2. Synthesis of N-(2-hydroxypropyl)methacrylamide copolymer-anti-Thy-1.2 antibody-chlorin e6 conjugates and a preliminary study of their photodynamic effect on mouse splenocytes in vitro
    • Krinick, N. L., Rihova, B., Ulbrich, K., Strohalm., J., and Kopecek, J. (1990) Targetable photoactive drugs 2. Synthesis of N-(2-hydroxypropyl)methacrylamide copolymer-anti-Thy-1.2 antibody-chlorin e6 conjugates and a preliminary study of their photodynamic effect on mouse splenocytes in vitro. Makromol. Chem. 191, 839-856.
    • (1990) Makromol. Chem. , vol.191 , pp. 839-856
    • Krinick, N.L.1    Rihova, B.2    Ulbrich, K.3    Strohalm, J.4    Kopecek, J.5
  • 232
    • 0022635574 scopus 로고
    • N-(2-Hydroxypropyl)-methacrylamide copolymers with pendant galactosamine residues. Fate after intravenous administartion to rats
    • Duncan, R., Seymour, L. W., Scarlett, L., Lloyd, J. B., Rejmanova, P., and Kopecek, J. (1986) N-(2-Hydroxypropyl)-methacrylamide copolymers with pendant galactosamine residues. Fate after intravenous administartion to rats. Biochim. Biophys. Acta 880, 62-71.
    • (1986) Biochim. Biophys. Acta , vol.880 , pp. 62-71
    • Duncan, R.1    Seymour, L.W.2    Scarlett, L.3    Lloyd, J.B.4    Rejmanova, P.5    Kopecek, J.6
  • 234
    • 0014202956 scopus 로고
    • Interferon induction in man by a synthetic polyanion of defined composition
    • Merigan, T. C., and Regelson, W. (1967) Interferon induction in man by a synthetic polyanion of defined composition. N. Engl. J. Med. 277, 1283-1287.
    • (1967) N. Engl. J. Med. , vol.277 , pp. 1283-1287
    • Merigan, T.C.1    Regelson, W.2
  • 235
    • 0001039302 scopus 로고
    • Attachment of drugs to polyethylene glycols
    • Zalipski, S., Gilon, C., and Zilkgha, A. (1983) Attachment of drugs to polyethylene glycols. Eur. Polym. J. 19, 1177-1183.
    • (1983) Eur. Polym. J. , vol.19 , pp. 1177-1183
    • Zalipski, S.1    Gilon, C.2    Zilkgha, A.3
  • 236
    • 0027235785 scopus 로고
    • Preparation and properties of monomethoxypoly(ethylene glycol) doxorubicin conjugates linked by an amnio acid or peptide as spacer
    • Caliceti, P., Monfardini C., Sartore, L., Schiavon, O., Baccicchetti, F., Carlassare, F., and Veronese, F. M. (1993) Preparation and properties of monomethoxypoly(ethylene glycol) doxorubicin conjugates linked by an amnio acid or peptide as spacer. Farmaco 48, 919-932.
    • (1993) Farmaco , vol.48 , pp. 919-932
    • Caliceti, P.1    Monfardini, C.2    Sartore, L.3    Schiavon, O.4    Baccicchetti, F.5    Carlassare, F.6    Veronese, F.M.7
  • 237
    • 0023596943 scopus 로고
    • Synthesis of 5-fluorouracil-terminated monomethoxypoly(ethylene glycol)s, their hydrolysis behaviour, and their antitumor activities
    • Ouchi, T., Yuyama, H., and Vogl, O. (1987) Synthesis of 5-fluorouracil-terminated monomethoxypoly(ethylene glycol)s, their hydrolysis behaviour, and their antitumor activities. J. Macromol. Sci. Chem. A24, 1011-1032.
    • (1987) J. Macromol. Sci. Chem. , vol.A24 , pp. 1011-1032
    • Ouchi, T.1    Yuyama, H.2    Vogl, O.3
  • 238
    • 0030071043 scopus 로고    scopus 로고
    • Drug-delivery systems: Water soluble taxol 2′-poly(ethylene glycol) ester prodrugs-Design and in vivo effectiveness
    • Greenwald, R. B., Gilbert, C. W., Pendri, A., Conover, C. D., Xia, J., and Martinez, A. (1996) Drug-delivery systems: water soluble taxol 2′-poly(ethylene glycol) ester prodrugs-Design and in vivo effectiveness. J. Med. Chem. 39, 424-431.
    • (1996) J. Med. Chem. , vol.39 , pp. 424-431
    • Greenwald, R.B.1    Gilbert, C.W.2    Pendri, A.3    Conover, C.D.4    Xia, J.5    Martinez, A.6
  • 239
    • 0029948533 scopus 로고    scopus 로고
    • Drug delivery systems. 2. Camptothecin 20-O-poly(ethylene glycol) ester transport forms
    • Greenwald, R. B., Pendri, A., Conover, C., Gilbert, C., Yang, R., and Xia, J. (1996) Drug delivery systems. 2. Camptothecin 20-O-poly(ethylene glycol) ester transport forms. J. Med. Chem. 39, 1938-1940.
    • (1996) J. Med. Chem. , vol.39 , pp. 1938-1940
    • Greenwald, R.B.1    Pendri, A.2    Conover, C.3    Gilbert, C.4    Yang, R.5    Xia, J.6
  • 240
    • 0028541088 scopus 로고
    • Conjugates of cis-4-hydroxy-L-proline and poly(PEG-Lys), a water soluble poly(ether urethane): Synthesis and evaluation of antifibrotic effects in vitro and in vivo
    • Poiani, G. J., Riley, D. J., Fox, J. D., Kemnizer, J. E., Gean, K. F., and Kohn, J. (1994) Conjugates of cis-4-hydroxy-L-proline and poly(PEG-Lys), a water soluble poly(ether urethane): synthesis and evaluation of antifibrotic effects in vitro and in vivo. Bioconjugate Chem. 5, 621-630.
    • (1994) Bioconjugate Chem. , vol.5 , pp. 621-630
    • Poiani, G.J.1    Riley, D.J.2    Fox, J.D.3    Kemnizer, J.E.4    Gean, K.F.5    Kohn, J.6
  • 241
    • 0028346185 scopus 로고
    • Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly(ethylene oxyde-aspartate) block copolymer-adryamicin conjugates
    • Kwon, G., Suwa, S., Yokoyama, M., Okano, T., Sakurai, Y., and Kataoka, K. (1994) Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly(ethylene oxyde-aspartate) block copolymer-adryamicin conjugates. J. Controlled Release 29, 17-23.
    • (1994) J. Controlled Release , vol.29 , pp. 17-23
    • Kwon, G.1    Suwa, S.2    Yokoyama, M.3    Okano, T.4    Sakurai, Y.5    Kataoka, K.6
  • 245
    • 0023222593 scopus 로고
    • Increased therapeutic efficacy and reduced toxicity of doxorubicin linked to pyran copolymer via the side-chain of the drug
    • Zunino, F., Pratesi, G., and Pezzoni, G. (1987) Increased therapeutic efficacy and reduced toxicity of doxorubicin linked to pyran copolymer via the side-chain of the drug. Cancer Treat. Rep. 71, 367-373.
    • (1987) Cancer Treat. Rep. , vol.71 , pp. 367-373
    • Zunino, F.1    Pratesi, G.2    Pezzoni, G.3
  • 246
    • 0023038740 scopus 로고
    • Activity of doxorubicin linked to poly-L-aspartic acid on normal murine hematopoietic progenitor cells
    • Bogliolo, G., Muzzulini, C., Lerza, R., and Pannacciulli, I. (1986) Activity of doxorubicin linked to poly-L-aspartic acid on normal murine hematopoietic progenitor cells. Cancer Treat. Rep. 70, 1275-1281.
    • (1986) Cancer Treat. Rep. , vol.70 , pp. 1275-1281
    • Bogliolo, G.1    Muzzulini, C.2    Lerza, R.3    Pannacciulli, I.4
  • 247
    • 0025853550 scopus 로고
    • Changes in the toxicity and therapeutic efficacy of daunorubicin linked with a biodegradable carrier
    • Hrdina, R., Bogusova, T. A., Kunova, A., and Kvetina, J. (1991) Changes in the toxicity and therapeutic efficacy of daunorubicin linked with a biodegradable carrier. Neoplasma 38, 265-273.
    • (1991) Neoplasma , vol.38 , pp. 265-273
    • Hrdina, R.1    Bogusova, T.A.2    Kunova, A.3    Kvetina, J.4
  • 248
    • 0006052482 scopus 로고
    • A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: In vitro and in vivo studies
    • Trouet, A., Masquelier, M., Baurain, R., and Campeneere, D. D. (1982) A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: in vitro and in vivo studies. Proc. Natl. Acad. Sci. U.S.A. 79, 626-629.
    • (1982) Proc. Natl. Acad. Sci. U.S.A. , vol.79 , pp. 626-629
    • Trouet, A.1    Masquelier, M.2    Baurain, R.3    Campeneere, D.D.4
  • 251
    • 0025147706 scopus 로고
    • Preparation proparties and antileukaemic activity of arabinosylcytosine polysaccharide conjugates
    • Kery, V., Novotny, L., Tihlarik, K., Haplova, J., Kacurakova, M., Sandula, J., and Balazova, E. (1990) Preparation proparties and antileukaemic activity of arabinosylcytosine polysaccharide conjugates. Int. J. Biochem. 22, 1203-1207.
    • (1990) Int. J. Biochem. , vol.22 , pp. 1203-1207
    • Kery, V.1    Novotny, L.2    Tihlarik, K.3    Haplova, J.4    Kacurakova, M.5    Sandula, J.6    Balazova, E.7
  • 252
    • 0025327413 scopus 로고
    • Synthesis and antitumor activity of conjugates of poly(α-malic acid) and 5-fluorouracils bound via ester, amide and carbamoyl bonds
    • Ouchi, T., Fujino, A., Tanaka, K., and Banba, T. (1990) Synthesis and antitumor activity of conjugates of poly(α-malic acid) and 5-fluorouracils bound via ester, amide and carbamoyl bonds. J. Controlled Release 12, 143-153.
    • (1990) J. Controlled Release , vol.12 , pp. 143-153
    • Ouchi, T.1    Fujino, A.2    Tanaka, K.3    Banba, T.4
  • 253
    • 0019780744 scopus 로고
    • Pharmacological and therapeutic properties of carrier bound methotrexate against tumor confined to a third space body compartment
    • Chu, B. C. F., and Howell, S. B. (1981) Pharmacological and therapeutic properties of carrier bound methotrexate against tumor confined to a third space body compartment. J. Pharmacol. Exp. Ther. 219, 389-393.
    • (1981) J. Pharmacol. Exp. Ther. , vol.219 , pp. 389-393
    • Chu, B.C.F.1    Howell, S.B.2
  • 255
    • 0018897432 scopus 로고
    • Anti-tumor activity of monomeric and polymeric cyclophosphamide derivative compound with in vitro hydrolysis
    • Hirano, T., Ringsford, H., and Zaharko, D. (1980) Anti-tumor activity of monomeric and polymeric cyclophosphamide derivative compound with in vitro hydrolysis. Cancer Res. 40, 2263-2267.
    • (1980) Cancer Res. , vol.40 , pp. 2263-2267
    • Hirano, T.1    Ringsford, H.2    Zaharko, D.3
  • 256
    • 0023811723 scopus 로고
    • Receptor-mediated gene delivery and expression in vivo
    • Wu, G. Y., and Wu, C. H. (1988) Receptor-mediated gene delivery and expression in vivo. J. Biol. Chem. 263, 14621-14624.
    • (1988) J. Biol. Chem. , vol.263 , pp. 14621-14624
    • Wu, G.Y.1    Wu, C.H.2
  • 258
    • 0000631893 scopus 로고
    • Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope
    • Bangham, A. D., and Horne, R. W. (1964) Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope. J. Mol. Biol. 8, 660-668.
    • (1964) J. Mol. Biol. , vol.8 , pp. 660-668
    • Bangham, A.D.1    Horne, R.W.2
  • 259
    • 0014441009 scopus 로고
    • Studies of phosphatidylcholine vesicles. Formation and physical characteristics
    • Huang, C. (1969) Studies of phosphatidylcholine vesicles. Formation and physical characteristics. Biochemistry 8, 344-352.
    • (1969) Biochemistry , vol.8 , pp. 344-352
    • Huang, C.1
  • 261
    • 0016820149 scopus 로고
    • Interaction of phospho-lipid vesicles with cells. Endocytosis and fusion as alternative mechanisms for the uptake of lipid-soluble and water-soluble molecules
    • Batzri, S., and Korn, E. D. (1975) Interaction of phospho-lipid vesicles with cells. Endocytosis and fusion as alternative mechanisms for the uptake of lipid-soluble and water-soluble molecules. J. Cell. Biol. 66, 621-634.
    • (1975) J. Cell. Biol. , vol.66 , pp. 621-634
    • Batzri, S.1    Korn, E.D.2
  • 270
    • 0016156147 scopus 로고
    • Control of the rate of hepatic uptake and catabolism of liposome-entrapped proteins injected into rat: Possible therapeutic applications
    • Gregoriadis, G., and Neerunjun, E. D. (1974) Control of the rate of hepatic uptake and catabolism of liposome-entrapped proteins injected into rat: possible therapeutic applications. Eur. J. Biochem. 47, 179-185.
    • (1974) Eur. J. Biochem. , vol.47 , pp. 179-185
    • Gregoriadis, G.1    Neerunjun, E.D.2
  • 271
    • 0022273738 scopus 로고
    • Uptake and intracellular processing of targeted and nontargeted liposomes by rat Kupffer cells in vivo and in vitro
    • Scherphof, G. L., Dikstra, J., Spanjer, H. H., Derksen, J. K., and Roerdink, T. (1985) Uptake and intracellular processing of targeted and nontargeted liposomes by rat Kupffer cells in vivo and in vitro. Ann. N.Y. Acad. Sci. 446, 368-384.
    • (1985) Ann. N.Y. Acad. Sci. , vol.446 , pp. 368-384
    • Scherphof, G.L.1    Dikstra, J.2    Spanjer, H.H.3    Derksen, J.K.4    Roerdink, T.5
  • 273
    • 0022572557 scopus 로고
    • A dried preparation of liposomes containing muramyl tripeptide phosphatidylethanolamine as a potent activator of human blood monocytes to the anticancer state
    • Sone, S., Utsugi, T., Tandon, P., and Ogawara, M. A. (1986) A dried preparation of liposomes containing muramyl tripeptide phosphatidylethanolamine as a potent activator of human blood monocytes to the anticancer state. Cancer Immunol. Immunother. 22, 191-196.
    • (1986) Cancer Immunol. Immunother. , vol.22 , pp. 191-196
    • Sone, S.1    Utsugi, T.2    Tandon, P.3    Ogawara, M.A.4
  • 274
    • 0026011075 scopus 로고
    • Liposomal delivery of biological response modifiers to macrophages
    • Pak, R. R., and Fidler, I. J., (1991) Liposomal delivery of biological response modifiers to macrophages. Biotherapy 3, 55-64.
    • (1991) Biotherapy , vol.3 , pp. 55-64
    • Pak, R.R.1    Fidler, I.J.2
  • 275
    • 0018796285 scopus 로고
    • Effect of fetal calf serum protein fractions on the uptake of liposomal phosphatidylcholine by rat hepatocytes in primary monolayer
    • Hoekstra, D., and Scherphof, G. (1979) Effect of fetal calf serum protein fractions on the uptake of liposomal phosphatidylcholine by rat hepatocytes in primary monolayer. Biochim. Biophys. Acta 551, 109-121.
    • (1979) Biochim. Biophys. Acta , vol.551 , pp. 109-121
    • Hoekstra, D.1    Scherphof, G.2
  • 276
    • 0020054716 scopus 로고
    • Doxorubicin-induced chronic cardiotoxicity and its protection by liposomal administration
    • Rahman, A., More, N., and Schein, P. S. (1982) Doxorubicin-induced chronic cardiotoxicity and its protection by liposomal administration. Cancer Res. 42, 1817-1825.
    • (1982) Cancer Res. , vol.42 , pp. 1817-1825
    • Rahman, A.1    More, N.2    Schein, P.S.3
  • 278
    • 0344311585 scopus 로고
    • Liposomal amphotericin B in antimicrobial therapy
    • (G. Gregoriadis, Ed.), Wiley & Sons, New York
    • Lopez-Berestein, G. (1988) Liposomal amphotericin B in antimicrobial therapy. In Liposomes as Drug Carriers (G. Gregoriadis, Ed.), pp 345-352, Wiley & Sons, New York.
    • (1988) Liposomes As Drug Carriers , pp. 345-352
    • Lopez-Berestein, G.1
  • 280
    • 0023157745 scopus 로고
    • Treatment of hepato-splenic fungal infections with liposomal amphotericin B
    • Lopez-Berestein, G., Bodey, G. P., Frankel, L. S., and Mehta, K. (1987) Treatment of hepato-splenic fungal infections with liposomal amphotericin B. J. Clin. Oncol. 5, 310-317.
    • (1987) J. Clin. Oncol. , vol.5 , pp. 310-317
    • Lopez-Berestein, G.1    Bodey, G.P.2    Frankel, L.S.3    Mehta, K.4
  • 281
    • 0026710677 scopus 로고
    • In vivo potentiation of ricin toxicity by monensin delivered through liposomes
    • Vasandani, V. M., Madan, S., and Ghosh, P. C. (1992) In vivo potentiation of ricin toxicity by monensin delivered through liposomes. Biochim. Biophys. Acta 1116, 315-323.
    • (1992) Biochim. Biophys. Acta , vol.1116 , pp. 315-323
    • Vasandani, V.M.1    Madan, S.2    Ghosh, P.C.3
  • 282
    • 0028264207 scopus 로고
    • Stabilization oftopotecan in low pH liposomes composed of distearylphosphatidylcholine
    • Burke, T. G., and Gao, X. (1994) Stabilization oftopotecan in low pH liposomes composed of distearylphosphatidylcholine. J. Pharm. Sci. 83, 967-968.
    • (1994) J. Pharm. Sci. , vol.83 , pp. 967-968
    • Burke, T.G.1    Gao, X.2
  • 283
  • 285
    • 0027185555 scopus 로고
    • Study of in vivo stability of oral liposomes loaded with calcitonin or indium in the gastrointestinal tract
    • Arien, A., Goigoux, C., Baquey, C., and Dupuy, B. (1993) Study of in vivo stability of oral liposomes loaded with calcitonin or indium in the gastrointestinal tract. Life Sci. 53, 1279-1290.
    • (1993) Life Sci. , vol.53 , pp. 1279-1290
    • Arien, A.1    Goigoux, C.2    Baquey, C.3    Dupuy, B.4
  • 286
    • 0021183196 scopus 로고
    • The in vivo release of cortisone esters from liposomes and the intramuscular clearance of liposomes
    • Arrowsmith, M., Hadgraft, J., and Kellaway, I. W. (1984) The in vivo release of cortisone esters from liposomes and the intramuscular clearance of liposomes. Int. J. Pharm. 20, 347-362.
    • (1984) Int. J. Pharm. , vol.20 , pp. 347-362
    • Arrowsmith, M.1    Hadgraft, J.2    Kellaway, I.W.3
  • 287
    • 0027220849 scopus 로고
    • Subcutaneous administration of liposomes: A comparison with the intravenous and intraperitoneal routes of injection
    • Allen, T. M., Hansen, C. B., and Guo, L. S. S. (1993) Subcutaneous administration of liposomes: a comparison with the intravenous and intraperitoneal routes of injection. Biochim. Biophys. Acta 1150, 9-16.
    • (1993) Biochim. Biophys. Acta , vol.1150 , pp. 9-16
    • Allen, T.M.1    Hansen, C.B.2    Guo, L.S.S.3
  • 288
    • 0021163146 scopus 로고
    • Stabilization of large multilamellar liposomes by human serum in vitro
    • Lelkes, P. I., and Friedmann, P. (1984) Stabilization of large multilamellar liposomes by human serum in vitro. Biochim. Biophys. Acta 775, 395-401.
    • (1984) Biochim. Biophys. Acta , vol.775 , pp. 395-401
    • Lelkes, P.I.1    Friedmann, P.2
  • 289
    • 0023280158 scopus 로고
    • Fate and behaviour of liposomes in vivo: A review of controlling factors
    • Senior, J. (1987) Fate and behaviour of liposomes in vivo: a review of controlling factors. Crit. Rev. Ther. Drug Carrier Syst. 3, 123-193.
    • (1987) Crit. Rev. Ther. Drug Carrier Syst. , vol.3 , pp. 123-193
    • Senior, J.1
  • 290
    • 0019886213 scopus 로고
    • A study of phospholipids interactions between high-density lipoproteins and small unilamellar vesicles
    • Allen, T. M. (1981) A study of phospholipids interactions between high-density lipoproteins and small unilamellar vesicles. Biochim. Biophys. Acta 640, 385-397.
    • (1981) Biochim. Biophys. Acta , vol.640 , pp. 385-397
    • Allen, T.M.1
  • 291
    • 0020578204 scopus 로고
    • Stability and clearance of small unilamellar liposomes: Studies with normal and lipoprotein deficient mice
    • Senior, J., Gregoriadis, G., and Mitropoulos, K. (1983) Stability and clearance of small unilamellar liposomes: studies with normal and lipoprotein deficient mice. Biochim. Biophys. Acta 760, 111-118.
    • (1983) Biochim. Biophys. Acta , vol.760 , pp. 111-118
    • Senior, J.1    Gregoriadis, G.2    Mitropoulos, K.3
  • 292
    • 0021042461 scopus 로고
    • Inhibitory effect of cholesterol on the uptake of liposomes by liver and spleen
    • Patel, H. M., Tuzel, N. S., and Ryman, B. E. (1983) Inhibitory effect of cholesterol on the uptake of liposomes by liver and spleen. Biochim. Biophys. Acta 761, 142-151.
    • (1983) Biochim. Biophys. Acta , vol.761 , pp. 142-151
    • Patel, H.M.1    Tuzel, N.S.2    Ryman, B.E.3
  • 293
    • 0020335352 scopus 로고
    • 14C]phosphatidylcholine between liposomes and human plasma high-density lipoproteins: Partial purification of a transfer stimulating factor using a rapid transfer assay
    • 14C]phosphatidylcholine between liposomes and human plasma high-density lipoproteins: partial purification of a transfer stimulating factor using a rapid transfer assay. Biochim. Biophys. Acta 712, 444-452.
    • (1982) Biochim. Biophys. Acta , vol.712 , pp. 444-452
    • Damen, J.1    Regts, J.2    Scherphof, G.L.3
  • 294
    • 0019184125 scopus 로고
    • Effect of lipoprotein-free plasma on the interaction of human plasma high-density lipoprotein with egg yolk phasphatidylcholine liposomes
    • Damen, J., Dijkstra, J., Regts, J., and Scherphof, G. L. (1980) Effect of lipoprotein-free plasma on the interaction of human plasma high-density lipoprotein with egg yolk phasphatidylcholine liposomes. Biochim. Biophys. Acta 620, 90-99.
    • (1980) Biochim. Biophys. Acta , vol.620 , pp. 90-99
    • Damen, J.1    Dijkstra, J.2    Regts, J.3    Scherphof, G.L.4
  • 295
    • 0020420111 scopus 로고
    • Particle size interconversion of human low-density lipoproteins during incubation of plasma with phosphatidylcholine vesicles
    • Shahrokh, Z., and Nichols, A. V. (1982) Particle size interconversion of human low-density lipoproteins during incubation of plasma with phosphatidylcholine vesicles. Biochem. Biophys. Res. Commun. 108, 888-895.
    • (1982) Biochem. Biophys. Res. Commun. , vol.108 , pp. 888-895
    • Shahrokh, Z.1    Nichols, A.V.2
  • 296
    • 0025325963 scopus 로고
    • Serum-induced leakage of negatively charged liposomes at nanomolar lipid concentration
    • Comiskey, S. J., and Heath, T. D. (1990) Serum-induced leakage of negatively charged liposomes at nanomolar lipid concentration. Biochemistry 29, 3626-3631.
    • (1990) Biochemistry , vol.29 , pp. 3626-3631
    • Comiskey, S.J.1    Heath, T.D.2
  • 297
    • 0019830489 scopus 로고
    • Transfer and exchange of phospholipid between small unilamellar liposomes and rat plasma high-density lipoproteins: Dependence on cholesterol and phospholipid composition
    • Damen, J., Regts, J., and Scherphof, G. L. (1981) Transfer and exchange of phospholipid between small unilamellar liposomes and rat plasma high-density lipoproteins: dependence on cholesterol and phospholipid composition. Biochim. Biophys. Acta 665, 538-545.
    • (1981) Biochim. Biophys. Acta , vol.665 , pp. 538-545
    • Damen, J.1    Regts, J.2    Scherphof, G.L.3
  • 298
    • 0020413201 scopus 로고
    • Liposomes disposition in vivo V. Liposomes stability in plasma and implications for drug carrier function
    • Hunt, C. A. (1982) Liposomes disposition in vivo V. Liposomes stability in plasma and implications for drug carrier function. Biochim. Biophys. Acta 719, 450-463.
    • (1982) Biochim. Biophys. Acta , vol.719 , pp. 450-463
    • Hunt, C.A.1
  • 299
    • 0019929258 scopus 로고
    • Is half-life of circulating liposomes determined by changes in their permeability?
    • Senior, J., and Gregoriadis, G. (1982) Is half-life of circulating liposomes determined by changes in their permeability? FEBS Lett. 145, 109-114.
    • (1982) FEBS Lett. , vol.145 , pp. 109-114
    • Senior, J.1    Gregoriadis, G.2
  • 300
    • 0020534959 scopus 로고
    • Stability of liposomes in circulation is markedly enhanced by structural modification of their phospholipid component
    • Bali, A., Dhawan, S., and Gupta, C. M. (1983) Stability of liposomes in circulation is markedly enhanced by structural modification of their phospholipid component. FEBS Lett. 154, 373-377.
    • (1983) FEBS Lett. , vol.154 , pp. 373-377
    • Bali, A.1    Dhawan, S.2    Gupta, C.M.3
  • 301
    • 0022546117 scopus 로고
    • Influence of the phospholipid structure in the stability of liposomes in serum
    • Agarwal, K., Bali, A., and Gupta, C. M. (1986) Influence of the phospholipid structure in the stability of liposomes in serum. Biochim. Biophys. Acta 856, 36-40.
    • (1986) Biochim. Biophys. Acta , vol.856 , pp. 36-40
    • Agarwal, K.1    Bali, A.2    Gupta, C.M.3
  • 302
    • 0021986941 scopus 로고
    • Modification of vesicles surface with amphiphilic sterols. Effect on permeability and in vivo tissue distribution
    • Patel, K. R., Li, M. P., Schuh, J. R., and Baldeschwielder, J. D. (1985) Modification of vesicles surface with amphiphilic sterols. Effect on permeability and in vivo tissue distribution. Biochim. Biophys. Acta 814, 256-264.
    • (1985) Biochim. Biophys. Acta , vol.814 , pp. 256-264
    • Patel, K.R.1    Li, M.P.2    Schuh, J.R.3    Baldeschwielder, J.D.4
  • 303
    • 0026631584 scopus 로고
    • Tumor accumulation of novel RES-avoiding liposomes
    • Oku, N., Namba, Y., and Okada, S. (1992) Tumor accumulation of novel RES-avoiding liposomes. Biochim. Biophys. Acta 1126, 255-260.
    • (1992) Biochim. Biophys. Acta , vol.1126 , pp. 255-260
    • Oku, N.1    Namba, Y.2    Okada, S.3
  • 304
    • 0019787534 scopus 로고
    • Interactions of liposomes with the reticuloendothelial system: Effects of reticuloendothelial blockade on the clearance of large unilamellar vesicles
    • Kao, Y. J., and Juliano, R. L. (1981) Interactions of liposomes with the reticuloendothelial system: effects of reticuloendothelial blockade on the clearance of large unilamellar vesicles. Biochim. Biophys. Acta 677, 453-461.
    • (1981) Biochim. Biophys. Acta , vol.677 , pp. 453-461
    • Kao, Y.J.1    Juliano, R.L.2
  • 306
    • 0020049344 scopus 로고
    • Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery
    • Poste, G., Bucana, C., Raz, A., Bugelski, P., Kiesh, R., and Fidler, I. J. (1982) Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery. Cancer Res. 42, 1412-1422.
    • (1982) Cancer Res. , vol.42 , pp. 1412-1422
    • Poste, G.1    Bucana, C.2    Raz, A.3    Bugelski, P.4    Kiesh, R.5    Fidler, I.J.6
  • 307
    • 0023002524 scopus 로고
    • Intrahepatic distribution of small unilamellar liposomes as a function of liposomal lipid composition
    • Spanier, H. H., Van Galen, M., Roerdink, F. H., Regts, J., and Scherphof, G. L. (1986) Intrahepatic distribution of small unilamellar liposomes as a function of liposomal lipid composition. Biochim. Biophys. Acta 863, 224-230.
    • (1986) Biochim. Biophys. Acta , vol.863 , pp. 224-230
    • Spanier, H.H.1    Van Galen, M.2    Roerdink, F.H.3    Regts, J.4    Scherphof, G.L.5
  • 308
    • 0021042461 scopus 로고
    • Inhibitory effect of cholesterol on the uptake of liposomes by liver and spleen
    • Patel, H. M., Tuzel, N. S., and Ryman, B. E. (1983) Inhibitory effect of cholesterol on the uptake of liposomes by liver and spleen. Biochim. Biophys. Acta 761, 142-151.
    • (1983) Biochim. Biophys. Acta , vol.761 , pp. 142-151
    • Patel, H.M.1    Tuzel, N.S.2    Ryman, B.E.3
  • 309
    • 0021848043 scopus 로고
    • Tissue distibution of liposomes exhibiting long half-lives in the circulation after intravenous injection
    • Senior, J., Crawley, J. C. W., and Gregoriadis, G. (1985) Tissue distibution of liposomes exhibiting long half-lives in the circulation after intravenous injection. Biochim. Biophys. Acta 839, 1-8.
    • (1985) Biochim. Biophys. Acta , vol.839 , pp. 1-8
    • Senior, J.1    Crawley, J.C.W.2    Gregoriadis, G.3
  • 310
    • 0025219143 scopus 로고
    • Scavanger receptor-mediated uptake and metabolism of lipid vesicles containing acidic phospholipids by mouse peritoneal macrophages
    • Nishikawa, K., Arai, H., and Inoue, K. (1990) Scavanger receptor-mediated uptake and metabolism of lipid vesicles containing acidic phospholipids by mouse peritoneal macrophages. J. Biol. Chem. 265, 5226-5231.
    • (1990) J. Biol. Chem. , vol.265 , pp. 5226-5231
    • Nishikawa, K.1    Arai, H.2    Inoue, K.3
  • 311
    • 0020610271 scopus 로고
    • Insertion of fluorescent phosphatidylserine into the plasma membrane of red blood cells: Recognition by autologous macrophages
    • Tanaka, Y., and Schroit, A. J. (1983) Insertion of fluorescent phosphatidylserine into the plasma membrane of red blood cells: recognition by autologous macrophages. J. Biol. Chem. 258, 11335-11343.
    • (1983) J. Biol. Chem. , vol.258 , pp. 11335-11343
    • Tanaka, Y.1    Schroit, A.J.2
  • 312
    • 0021327049 scopus 로고
    • Liposome disposition in vivo VI: Delivery to the lung
    • Abra, R. M., Hunt, C. A., and Lau, D. T. (1984) Liposome disposition in vivo VI: delivery to the lung. J. Pharm. Sci. 73, 203-206.
    • (1984) J. Pharm. Sci. , vol.73 , pp. 203-206
    • Abra, R.M.1    Hunt, C.A.2    Lau, D.T.3
  • 313
    • 0026575128 scopus 로고
    • Contribution of complement system on destabilization of liposomes composed of hydrogenated egg phosphatidylcholine in rat fresh plasma
    • Funato, K., Yoda, R., and Kiwada, H. (1992) Contribution of complement system on destabilization of liposomes composed of hydrogenated egg phosphatidylcholine in rat fresh plasma. Biochim. Biophys. Acta 1103, 198-204.
    • (1992) Biochim. Biophys. Acta , vol.1103 , pp. 198-204
    • Funato, K.1    Yoda, R.2    Kiwada, H.3
  • 314
    • 0026778635 scopus 로고
    • Association of blood proteins with large unilamellar liposomes in vivo
    • Chonn, A., Semple, S. C., and Cullis, P. R. (1992) Association of blood proteins with large unilamellar liposomes in vivo. J. Biol. Chem. 267, 18759-18765.
    • (1992) J. Biol. Chem. , vol.267 , pp. 18759-18765
    • Chonn, A.1    Semple, S.C.2    Cullis, P.R.3
  • 315
    • 0025934603 scopus 로고
    • Interaction of positively charged liposomes with blood: Implications for their application in vivo
    • Senior, J. H., Trimble, K. R., and Maskiewitz, R. (1991) Interaction of positively charged liposomes with blood: implications for their application in vivo. Biochim. Biophys. Acta 1070, 173-179.
    • (1991) Biochim. Biophys. Acta , vol.1070 , pp. 173-179
    • Senior, J.H.1    Trimble, K.R.2    Maskiewitz, R.3
  • 316
    • 0024603656 scopus 로고
    • Targeting small unilamellar liposomes to hepatic parenchymal cells by dose effect
    • Chow, D. D., Essien, H. E., Padki, M. M., and Hwang, K. J. (1989) Targeting small unilamellar liposomes to hepatic parenchymal cells by dose effect. J. Pharm. Exp. Ther. 248, 506-513.
    • (1989) J. Pharm. Exp. Ther. , vol.248 , pp. 506-513
    • Chow, D.D.1    Essien, H.E.2    Padki, M.M.3    Hwang, K.J.4
  • 317
    • 0023915673 scopus 로고
    • Increased delivery of gallium-67 to tumors using serum-stable liposomes
    • Ogihara-Umeda, I., and Kojima, S. (1988) Increased delivery of gallium-67 to tumors using serum-stable liposomes. J. Nucl. Med. 29, 516-523.
    • (1988) J. Nucl. Med. , vol.29 , pp. 516-523
    • Ogihara-Umeda, I.1    Kojima, S.2
  • 318
    • 0344743920 scopus 로고
    • Specific rejection of glycophorin-reconstituted liposomes by human phagocytes
    • Goto, M., Arakawa, M., Sato, T., Kondo, H., and Sunamoto, J. (1987) Specific rejection of glycophorin-reconstituted liposomes by human phagocytes. Chem. Lett. 2, 1935-1938.
    • (1987) Chem. Lett. , vol.2 , pp. 1935-1938
    • Goto, M.1    Arakawa, M.2    Sato, T.3    Kondo, H.4    Sunamoto, J.5
  • 319
    • 0023659741 scopus 로고
    • Large unilamellar liposomes with low uptake into the reticuloendothelial system
    • Allen, T. M., and Chonn, A. (1987) Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS Lett. 223, 42-46.
    • (1987) FEBS Lett. , vol.223 , pp. 42-46
    • Allen, T.M.1    Chonn, A.2
  • 320
    • 0842279809 scopus 로고
    • Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors
    • Gabizon, A., and Paphadjopoulos, D. (1988) Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc. Natl. Acad. Sci. U.S.A. 85 6949-6953.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 6949-6953
    • Gabizon, A.1    Paphadjopoulos, D.2
  • 321
    • 0024551243 scopus 로고
    • Liposomes with prolonged circulation times: Factors affecting uptake by reticuloendothelial and other tissues
    • Allen, T. M., Hansen, C., and Rutledge, J. (1989) Liposomes with prolonged circulation times: factors affecting uptake by reticuloendothelial and other tissues. Biochim. Biophys. Acta 981, 27-35.
    • (1989) Biochim. Biophys. Acta , vol.981 , pp. 27-35
    • Allen, T.M.1    Hansen, C.2    Rutledge, J.3
  • 322
    • 0025053067 scopus 로고
    • Liposomes for the sustained drug release in vivo
    • Blume, G., and Cevc, G. (1990) Liposomes for the sustained drug release in vivo. Biochim. Biophys. Acta 1029, 91-97.
    • (1990) Biochim. Biophys. Acta , vol.1029 , pp. 91-97
    • Blume, G.1    Cevc, G.2
  • 323
    • 0025731906 scopus 로고
    • Liposomes containing synthetic lipid derivatives of poly(ethyleneglycol) show prolonged circulation half-lives in vivo
    • Allen, T. M., Hansen, G., Martin, F., Redeman, C., and Yau-Young, A. (1991) Liposomes containing synthetic lipid derivatives of poly(ethyleneglycol) show prolonged circulation half-lives in vivo. Biochim. Biophys. Acta 1066, 29-36.
    • (1991) Biochim. Biophys. Acta , vol.1066 , pp. 29-36
    • Allen, T.M.1    Hansen, G.2    Martin, F.3    Redeman, C.4    Yau-Young, A.5
  • 324
    • 0026567096 scopus 로고
    • Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes
    • Liu, D., Mori, A., and Huang, L. (1992) Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes. Biochim. Biophys. Acta 1104, 95-101.
    • (1992) Biochim. Biophys. Acta , vol.1104 , pp. 95-101
    • Liu, D.1    Mori, A.2    Huang, L.3
  • 326
    • 0027172923 scopus 로고
    • 99mTc-labeled liposomal blood pool agents for nuclear medicine applications
    • 99mTc-labeled liposomal blood pool agents for nuclear medicine applications. Biochim. Biophys. Acta 1148, 77-84.
    • (1993) Biochim. Biophys. Acta , vol.1148 , pp. 77-84
    • Tilcock, C.1    Ahkong, Q.F.2    Fisher, D.3
  • 327
    • 0027400065 scopus 로고
    • Effects of glycophorin and ganglioside GM3 on the blood circulation and tissue distribution of liposomes in rats
    • Yamauchi, H., Kikuchi, H., Yachi, K., Sawada, M., Tomikawa, M., and Hirota, S. (1993) Effects of glycophorin and ganglioside GM3 on the blood circulation and tissue distribution of liposomes in rats. Int. J. Pharmacol. 90, 73-79.
    • (1993) Int. J. Pharmacol. , vol.90 , pp. 73-79
    • Yamauchi, H.1    Kikuchi, H.2    Yachi, K.3    Sawada, M.4    Tomikawa, M.5    Hirota, S.6
  • 328
    • 0026054526 scopus 로고
    • Uptake of liposomes by cultured mouse bone marrow macrophages: Influence of liposome composition and size
    • Allen, T. M., Austin, G. A., Chonn, A., Lin, L., and Lee, K. C. (1991) Uptake of liposomes by cultured mouse bone marrow macrophages: influence of liposome composition and size. Biochim. Biophys. Acta 1061, 56-64.
    • (1991) Biochim. Biophys. Acta , vol.1061 , pp. 56-64
    • Allen, T.M.1    Austin, G.A.2    Chonn, A.3    Lin, L.4    Lee, K.C.5
  • 329
    • 0026689418 scopus 로고
    • Some negatively charged phospholipid derivatives prolong the liposome circulation in vivo
    • Park, Y. S., Maruyama, K., and Huang, L. (1992) Some negatively charged phospholipid derivatives prolong the liposome circulation in vivo. Biochim. Biophys. Acta 1108, 257-260.
    • (1992) Biochim. Biophys. Acta , vol.1108 , pp. 257-260
    • Park, Y.S.1    Maruyama, K.2    Huang, L.3
  • 330
    • 0025071084 scopus 로고
    • Glucuronate-modified liposomes with prolonged circulation time
    • Namba, Y., Sakakibara, T., Masada, M., Ito, F., and Oku, N. (1990) Glucuronate-modified liposomes with prolonged circulation time. Chem. Pharm. Bull. 38, 1663-1666.
    • (1990) Chem. Pharm. Bull. , vol.38 , pp. 1663-1666
    • Namba, Y.1    Sakakibara, T.2    Masada, M.3    Ito, F.4    Oku, N.5
  • 331
    • 0026540996 scopus 로고
    • Prolonged systemic delivery of peptide drugs by long-circulating liposomes: Illustration with vasopressin in the Brattlebor rat
    • Woodle, M. C., Storm, G., Newman, M. S., Jekot, J. J., Collins, L. R., Martin, F. J., and Szoka, F. C., Jr. (1992) Prolonged systemic delivery of peptide drugs by long-circulating liposomes: illustration with vasopressin in the Brattlebor rat. Pharmacol. Res. 9, 260-265.
    • (1992) Pharmacol. Res. , vol.9 , pp. 260-265
    • Woodle, M.C.1    Storm, G.2    Newman, M.S.3    Jekot, J.J.4    Collins, L.R.5    Martin, F.J.6    Szoka F.C., Jr.7
  • 332
    • 0026548099 scopus 로고
    • Liposomal modification with uronate, which endows liposomes with long circulation in vivo, reduces the uptake of liposomes by J774 cells in vitro
    • Namba, Y., Oku, N., Ito, F., Sakakibara, T., and Okada, S. (1992) Liposomal modification with uronate, which endows liposomes with long circulation in vivo, reduces the uptake of liposomes by J774 cells in vitro. Life Sci. 50, 1773-1779.
    • (1992) Life Sci. , vol.50 , pp. 1773-1779
    • Namba, Y.1    Oku, N.2    Ito, F.3    Sakakibara, T.4    Okada, S.5
  • 333
    • 0345606128 scopus 로고
    • Photopolymerized phospholipid vesicles: Stability and retention of hydrophilic and hydrophobic marker substances
    • Juliano, R. L., Hsu, M. J., Regen, S. L., and Singh, M. (1984) Photopolymerized phospholipid vesicles: stability and retention of hydrophilic and hydrophobic marker substances. Biochim. Biophys. Acta 770, 109-114.
    • (1984) Biochim. Biophys. Acta , vol.770 , pp. 109-114
    • Juliano, R.L.1    Hsu, M.J.2    Regen, S.L.3    Singh, M.4
  • 335
    • 0026710312 scopus 로고
    • Repulsive interactions and mechanical stability of polymer-grafted lipid membranes
    • Needham, D., McIntosh, T. J., and Lasic, D. D. (1992) Repulsive interactions and mechanical stability of polymer-grafted lipid membranes. Biochim. Biophys. Acta 1108, 4-48.
    • (1992) Biochim. Biophys. Acta , vol.1108 , pp. 4-48
    • Needham, D.1    McIntosh, T.J.2    Lasic, D.D.3
  • 336
    • 0029789505 scopus 로고    scopus 로고
    • Theoretical considerations on self-similarity of the polyethylene glycol-coated liposomal surface
    • Hoop, B., and Torchilin, V. P. (1996) Theoretical considerations on self-similarity of the polyethylene glycol-coated liposomal surface. Proc. Int. Symp. Controlled Release Bioact. Mater., 23rd, 785-786.
    • (1996) Proc. Int. Symp. Controlled Release Bioact. Mater., 23rd , pp. 785-786
    • Hoop, B.1    Torchilin, V.P.2
  • 337
    • 0025981079 scopus 로고
    • Activity of amphipathic poly-(ethylene glycol) 5,000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposomes binding to target
    • Klibanov, A. L., Maruyama, K., Beckerleg, A. M., Torchilin, V. P., and Huang, L. (1991) Activity of amphipathic poly-(ethylene glycol) 5,000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposomes binding to target. Biochim. Biophys. Acta 1062, 142-148.
    • (1991) Biochim. Biophys. Acta , vol.1062 , pp. 142-148
    • Klibanov, A.L.1    Maruyama, K.2    Beckerleg, A.M.3    Torchilin, V.P.4    Huang, L.5
  • 340
    • 0027399121 scopus 로고
    • Molecular mechanism of the lipid vesicle longevity in vivo
    • Blume, G., and Cevc, G. (1993) Molecular mechanism of the lipid vesicle longevity in vivo. Biochim. Biophys. Acta 1146, 157-168.
    • (1993) Biochim. Biophys. Acta , vol.1146 , pp. 157-168
    • Blume, G.1    Cevc, G.2
  • 341
    • 0028053658 scopus 로고
    • Factors influencing the retention and chemical stability of poly(ethylene glycol)-lipid conjugates incorporated into large unilamellar vesicles
    • Parr, M. J., Ansell, S. M., Lewis, S. C., and Cullis, P. R. (1994) Factors influencing the retention and chemical stability of poly(ethylene glycol)-lipid conjugates incorporated into large unilamellar vesicles. Biochim. Biophys. Acta 1195, 21-30.
    • (1994) Biochim. Biophys. Acta , vol.1195 , pp. 21-30
    • Parr, M.J.1    Ansell, S.M.2    Lewis, S.C.3    Cullis, P.R.4
  • 342
    • 0026671099 scopus 로고
    • Prolonged circulation time in vivo of large unilamellar liposomes composed of distearoylphosphatidylcholine and cholesterol containing amphipathic poly(ethylene glycol)
    • Maruyama, K., Yuda, T., Okamoto, A., Kojima, S., Suginaka A., and Iwatsuru, M. (1992) Prolonged circulation time in vivo of large unilamellar liposomes composed of distearoylphosphatidylcholine and cholesterol containing amphipathic poly(ethylene glycol). Biochim. Biophys. Acta 1128, 44-49.
    • (1992) Biochim. Biophys. Acta , vol.1128 , pp. 44-49
    • Maruyama, K.1    Yuda, T.2    Okamoto, A.3    Kojima, S.4    Suginaka, A.5    Iwatsuru, M.6
  • 343
    • 0028055226 scopus 로고
    • Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes
    • Litzinger, D. C., Buiting, A. M. J., van Rooijen, N., and Huang, L. (1994) Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes. Biochim. Biophys. Acta 1190, 99-107.
    • (1994) Biochim. Biophys. Acta , vol.1190 , pp. 99-107
    • Litzinger, D.C.1    Buiting, A.M.J.2    Van Rooijen, N.3    Huang, L.4
  • 344
    • 0029905864 scopus 로고    scopus 로고
    • Prolongation of liposome circulation time by various derivatives of polyethylene glycols
    • Yuda, T., Maruyama, K., and Iwatsuru, M. (1996) Prolongation of liposome circulation time by various derivatives of polyethylene glycols. Biol. Pharm. Bull. 19, 1347-1351.
    • (1996) Biol. Pharm. Bull. , vol.19 , pp. 1347-1351
    • Yuda, T.1    Maruyama, K.2    Iwatsuru, M.3
  • 347
    • 0027986535 scopus 로고
    • Mucoadhesion of polymer-coated liposomes to rat intestine in vitro
    • Takeuchi, H., Yamamoto, H., Niwa, T., Hino, T. and Kawashima, Y. (1994) Mucoadhesion of polymer-coated liposomes to rat intestine in vitro. Chem. Pharm. Bull. 42, 1954-1956.
    • (1994) Chem. Pharm. Bull. , vol.42 , pp. 1954-1956
    • Takeuchi, H.1    Yamamoto, H.2    Niwa, T.3    Hino, T.4    Kawashima, Y.5
  • 348
    • 0029895328 scopus 로고    scopus 로고
    • Enterai absorption of insulin in rats from mucoadhesive chitosan-coated liposomes
    • Takeuchi, H., Yamamoto, H., Niwa, T., Hino, T., and Kawashima, Y. (1996) Enterai absorption of insulin in rats from mucoadhesive chitosan-coated liposomes. Pharm. Res. 13, 896-901.
    • (1996) Pharm. Res. , vol.13 , pp. 896-901
    • Takeuchi, H.1    Yamamoto, H.2    Niwa, T.3    Hino, T.4    Kawashima, Y.5
  • 350
    • 0028540519 scopus 로고
    • New amphipathic polymer-lipid conjugates forming long-circulating reticuloendothelial system-evading liposomes
    • Woodle, M. C., Engbers, C. M., and Zalipsky, S. (1994) New amphipathic polymer-lipid conjugates forming long-circulating reticuloendothelial system-evading liposomes. Bioconjugate Chem. 5, 493-496.
    • (1994) Bioconjugate Chem. , vol.5 , pp. 493-496
    • Woodle, M.C.1    Engbers, C.M.2    Zalipsky, S.3
  • 351
    • 0031011742 scopus 로고    scopus 로고
    • Surface coating of liposomes with hydrophobized polysaccharides
    • Kang, E. C., Akiyoshi, K., and Sunamoto, J. (1997) Surface coating of liposomes with hydrophobized polysaccharides. J. Bioact. Compat. Polym. 12, 14-26.
    • (1997) J. Bioact. Compat. Polym. , vol.12 , pp. 14-26
    • Kang, E.C.1    Akiyoshi, K.2    Sunamoto, J.3
  • 352
  • 354
    • 0031149344 scopus 로고    scopus 로고
    • Transient suppression of macrophage function by liposomes-encapsulated drugs
    • van Rooijen, N., Bakekr, J., and Sander, A. (1997) Transient suppression of macrophage function by liposomes-encapsulated drugs. Trends Biotechnol. 15, 178-185.
    • (1997) Trends Biotechnol. , vol.15 , pp. 178-185
    • Van Rooijen, N.1    Bakekr, J.2    Sander, A.3
  • 355
    • 0024206630 scopus 로고
    • Quantitation of a murine lung endothelial cell protein, p112, with a double monoclonal antibody assay
    • Kennel, S. J., Lankford, T., Hughes, B., and Hotchkiss, J. (1988) Quantitation of a murine lung endothelial cell protein, p112, with a double monoclonal antibody assay. Lab. Invest. 59, 692-701.
    • (1988) Lab. Invest. , vol.59 , pp. 692-701
    • Kennel, S.J.1    Lankford, T.2    Hughes, B.3    Hotchkiss, J.4
  • 356
    • 0025346213 scopus 로고
    • Lipid composition is important for highly efficient target binding and retention of immunoliposomes
    • Maruyama, K., Kennel, S., and Huang, L. (1990) Lipid composition is important for highly efficient target binding and retention of immunoliposomes. Proc. Natl. Acad. Sci. U.S.A. 87, 5744-5748.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 5744-5748
    • Maruyama, K.1    Kennel, S.2    Huang, L.3
  • 357
    • 0025854252 scopus 로고
    • Influence of the steric barrier activity of amphipathic poly(ethylene glycol) and ganglioside GM1 on the circulation time of liposomes and the target binding of immunoliposomes in vivo
    • Mori, A., Klibanov, A. L., Torchilin, V. P., and Huang, L. (1991) Influence of the steric barrier activity of amphipathic poly(ethylene glycol) and ganglioside GM1 on the circulation time of liposomes and the target binding of immunoliposomes in vivo. FEBS Lett. 284, 263-266.
    • (1991) FEBS Lett. , vol.284 , pp. 263-266
    • Mori, A.1    Klibanov, A.L.2    Torchilin, V.P.3    Huang, L.4
  • 359
    • 0029937913 scopus 로고    scopus 로고
    • Preparation and characterization of doxorubicin-loaded sterically stabilized immunoliposomes
    • Emanuel, N., Kedar, E., Bolotin, E. M., Smorodinsky, N. I., and Barenholz, Y. (1996) Preparation and characterization of doxorubicin-loaded sterically stabilized immunoliposomes. Pharm. Res. 13, 352-359.
    • (1996) Pharm. Res. , vol.13 , pp. 352-359
    • Emanuel, N.1    Kedar, E.2    Bolotin, E.M.3    Smorodinsky, N.I.4    Barenholz, Y.5
  • 360
    • 0027157735 scopus 로고
    • Specific targeting with poly(ethylene glycol)-modified liposomes: Coupling of homing devices to the ends of the polymeric chains combines effective target binding with long circulation times
    • Blume, G., Cevc, G., Crommelin, M. D., Bakker-Woundenberg, I. A., Kluft, C., and Storm. G. (1993) Specific targeting with poly(ethylene glycol)-modified liposomes: coupling of homing devices to the ends of the polymeric chains combines effective target binding with long circulation times. Biochim. Biophys. Acta 1149, 180-184.
    • (1993) Biochim. Biophys. Acta , vol.1149 , pp. 180-184
    • Blume, G.1    Cevc, G.2    Crommelin, M.D.3    Bakker-Woundenberg, I.A.4    Kluft, C.5    Storm, G.6
  • 361
    • 0031105393 scopus 로고    scopus 로고
    • Poly(ethylene glycol)-grafted liposomes with oligopeptide or oligosaccharide ligands appended to the termini of the polymer chains
    • Zalipsky, S., Mullah, N., Harding, J. A., Gittelma, J., Guo, L., and DeFrees, S. A. (1997) Poly(ethylene glycol)-grafted liposomes with oligopeptide or oligosaccharide ligands appended to the termini of the polymer chains. Bioconjugate Chem. 8, 111-118.
    • (1997) Bioconjugate Chem. , vol.8 , pp. 111-118
    • Zalipsky, S.1    Mullah, N.2    Harding, J.A.3    Gittelma, J.4    Guo, L.5    DeFrees, S.A.6
  • 362
    • 0030841096 scopus 로고    scopus 로고
    • Biodistribution of cyclosporin encapsualted in liposomes modified with bioadhesive polymer
    • Yoshikawa, Y., Miyazaki, M., Houjou, T., Komuta, Y., Yoshikawa, H., and Takada, K. (1997) Biodistribution of cyclosporin encapsualted in liposomes modified with bioadhesive polymer. J. Pharm. Pharmacol. 49, 661-668.
    • (1997) J. Pharm. Pharmacol. , vol.49 , pp. 661-668
    • Yoshikawa, Y.1    Miyazaki, M.2    Houjou, T.3    Komuta, Y.4    Yoshikawa, H.5    Takada, K.6
  • 363
    • 0027231107 scopus 로고
    • Enhanced delivery of doxorubicin to tumor by long circulating thermosensitive liposomes and local hyperthermia
    • Maruyama, K., Unezaki, S., Takahashi, N., and Iwatsuru, M. (1993) Enhanced delivery of doxorubicin to tumor by long circulating thermosensitive liposomes and local hyperthermia. Biochim. Biophys. Acta 1149, 209-216.
    • (1993) Biochim. Biophys. Acta , vol.1149 , pp. 209-216
    • Maruyama, K.1    Unezaki, S.2    Takahashi, N.3    Iwatsuru, M.4
  • 364
    • 0001636498 scopus 로고
    • Liposomes and hyperthemia in mice: Increased tumor uptake and therapeutic efficacy of doxorubicin in sterically stabilized liposomes
    • Huang, S. K., Stauffer, P. R., Hong, K., Guo, J. W. H., Phillips, T. L., Huang, A., and Papahadjopoulos, D. (1994) Liposomes and hyperthemia in mice: increased tumor uptake and therapeutic efficacy of doxorubicin in sterically stabilized liposomes. Cancer Res. 54, 2186-2191.
    • (1994) Cancer Res. , vol.54 , pp. 2186-2191
    • Huang, S.K.1    Stauffer, P.R.2    Hong, K.3    Guo, J.W.H.4    Phillips, T.L.5    Huang, A.6    Papahadjopoulos, D.7
  • 365
    • 0027967151 scopus 로고
    • Enhanced delivery and antitumor activity of doxorubicin using long-circulating thermosensitive liposomes containing amphipathic polyethylene glycol in combination with local hyperthermia
    • Unezaki, S., Maruyama, K., Takahashi, N., Koyama, M., Yuda, T., Suginaka, A., and Iwatsuru, M. (1994) Enhanced delivery and antitumor activity of doxorubicin using long-circulating thermosensitive liposomes containing amphipathic polyethylene glycol in combination with local hyperthermia. Pharm. Res. 11, 1180-1185.
    • (1994) Pharm. Res. , vol.11 , pp. 1180-1185
    • Unezaki, S.1    Maruyama, K.2    Takahashi, N.3    Koyama, M.4    Yuda, T.5    Suginaka, A.6    Iwatsuru, M.7
  • 367
    • 0000497921 scopus 로고
    • pH-sensitive liposomes: Acid-induced liposomes fusion
    • Connor, J., Yatvin, M. B., and Huang, L. (1984) pH-sensitive liposomes: acid-induced liposomes fusion. Proc. Natl. Acad. Sci. U.S.A. 81, 1715-1718.
    • (1984) Proc. Natl. Acad. Sci. U.S.A. , vol.81 , pp. 1715-1718
    • Connor, J.1    Yatvin, M.B.2    Huang, L.3
  • 368
    • 0022640122 scopus 로고
    • pH-sensitive immunoliposomes as an efficient and target-specific carrier for antitumor drugs
    • Connor, J., and Huang, L. (1986) pH-sensitive immunoliposomes as an efficient and target-specific carrier for antitumor drugs. Cancer Res. 46, 3431-3435.
    • (1986) Cancer Res. , vol.46 , pp. 3431-3435
    • Connor, J.1    Huang, L.2
  • 369
    • 0023657167 scopus 로고
    • Low pH induced membrane fusion of lipid vesicles containing proton-sensitive polymer
    • Oku, N., Shibamoto, S., Ito, F., Gondo, H., and Nango, M. (1987) Low pH induced membrane fusion of lipid vesicles containing proton-sensitive polymer. Biochemistry 26, 8145-8150.
    • (1987) Biochemistry , vol.26 , pp. 8145-8150
    • Oku, N.1    Shibamoto, S.2    Ito, F.3    Gondo, H.4    Nango, M.5
  • 370
    • 0022999335 scopus 로고
    • Target-sensitive immunoliposomes: Preparation and characterization
    • Ho, R. J. Y., Rouse, B. T., and Huang, L. (1986) Target-sensitive immunoliposomes: preparation and characterization. Biochemistry 25, 5500-5506.
    • (1986) Biochemistry , vol.25 , pp. 5500-5506
    • Ho, R.J.Y.1    Rouse, B.T.2    Huang, L.3
  • 371
    • 0023637179 scopus 로고
    • Target-sensitive immunoliposomes as an efficient drug carrier for antiviral activity
    • Ho, R. J. Y., Rouse, B. T., and Huang, L. (1987) Target-sensitive immunoliposomes as an efficient drug carrier for antiviral activity. J. Biol. Chem. 262, 13973-13978.
    • (1987) J. Biol. Chem. , vol.262 , pp. 13973-13978
    • Ho, R.J.Y.1    Rouse, B.T.2    Huang, L.3
  • 373
    • 0029837771 scopus 로고    scopus 로고
    • Preparation and evaluation of pH-sensitive long-circulating liposomes entrapped methotrexate
    • Hong, M. S., and Kim, C. K. (1996) Preparation and evaluation of pH-sensitive long-circulating liposomes entrapped methotrexate. Proc. Int. Symp. Controlled Release Bioact. Mater., 23rd, 923-924.
    • (1996) Proc. Int. Symp. Controlled Release Bioact. Mater., 23rd , pp. 923-924
    • Hong, M.S.1    Kim, C.K.2
  • 375
    • 0031058496 scopus 로고    scopus 로고
    • pH-sensitive liposomes: An intelligent system for the delivery of antisense oligonucleotides
    • Couveur, P., Fattal, E., Malvy, C., and Dubernet, C. (1997) pH-sensitive liposomes: an intelligent system for the delivery of antisense oligonucleotides. J. Liposome Res. 7, 1-18.
    • (1997) J. Liposome Res. , vol.7 , pp. 1-18
    • Couveur, P.1    Fattal, E.2    Malvy, C.3    Dubernet, C.4
  • 376
    • 0025162391 scopus 로고
    • Effect of liposome composition and other factors on the targeting of liposomes to experimental tumors: Biodistribution and imaging studies
    • Gabizon, A., Prince, D. C., Huberty, J., Bresalier, R. S., and Papahadjopoulos, D. (1990) Effect of liposome composition and other factors on the targeting of liposomes to experimental tumors: biodistribution and imaging studies. Cancer Res. 50, 6371-6378.
    • (1990) Cancer Res. , vol.50 , pp. 6371-6378
    • Gabizon, A.1    Prince, D.C.2    Huberty, J.3    Bresalier, R.S.4    Papahadjopoulos, D.5
  • 377
    • 0027339279 scopus 로고
    • 67Gallium-labeled liposomes with prolonged circulation: Preparation and potential as nuclear imaging agents
    • 67Gallium-labeled liposomes with prolonged circulation: preparation and potential as nuclear imaging agents. Nucl. Med. Biol. 20, 149-155.
    • (1993) Nucl. Med. Biol. , vol.20 , pp. 149-155
    • Woodle, M.C.1
  • 378
    • 0027155456 scopus 로고
    • Tumor imaging with technetium-99m-DTPA encapsulated in RES-avoiding liposomes
    • Oku, N., Namba, Y., Takeda, A., and Okada, S. (1993) Tumor imaging with technetium-99m-DTPA encapsulated in RES-avoiding liposomes. Nucl. Med. Biol. 20, 407-412.
    • (1993) Nucl. Med. Biol. , vol.20 , pp. 407-412
    • Oku, N.1    Namba, Y.2    Takeda, A.3    Okada, S.4
  • 379
    • 0026603586 scopus 로고
    • Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes
    • Gabizon, A. (1992) Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes. Cancer Res. 52, 891-896.
    • (1992) Cancer Res. , vol.52 , pp. 891-896
    • Gabizon, A.1
  • 381
    • 0027050420 scopus 로고
    • Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma
    • Huang, S. K., Nayhew, E., Gilani, S., Lasic, D. D., Martin, F. J., and Papahadjopoulos, D. (1992) Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma. Cancer Res. 52, 6774-6781.
    • (1992) Cancer Res. , vol.52 , pp. 6774-6781
    • Huang, S.K.1    Nayhew, E.2    Gilani, S.3    Lasic, D.D.4    Martin, F.J.5    Papahadjopoulos, D.6
  • 382
    • 0028040403 scopus 로고
    • Therapeutic effect of adriamycin encapsulated in long-circulating liposomes on Meth-A-sarcoma-bearing mice
    • Oku, N., Doi, K., Namba, Y., and Okada, S. (1994) Therapeutic effect of adriamycin encapsulated in long-circulating liposomes on Meth-A-sarcoma-bearing mice. Int. J. Cancer 58, 415-419.
    • (1994) Int. J. Cancer , vol.58 , pp. 415-419
    • Oku, N.1    Doi, K.2    Namba, Y.3    Okada, S.4
  • 383
    • 0026751917 scopus 로고
    • Therapy of primary and metastatic mouse mammary carcinomas with doxorubicin encapsulated in long circulating liposomes
    • Vaage, J., Mayhew, E., Lasic, D., and Martin, F. (1992) Therapy of primary and metastatic mouse mammary carcinomas with doxorubicin encapsulated in long circulating liposomes. Int. J. Cancer 51, 942-948.
    • (1992) Int. J. Cancer , vol.51 , pp. 942-948
    • Vaage, J.1    Mayhew, E.2    Lasic, D.3    Martin, F.4
  • 384
    • 0028270397 scopus 로고
    • Chemoprevention and therapy of mouse mammary carcinomas with doxorubicin encapsulated in sterically stabilized liposomes
    • Vaage, J., Donovan, D., Loftus, T., Abra, R., Working, P., and Huang, A. (1994) Chemoprevention and therapy of mouse mammary carcinomas with doxorubicin encapsulated in sterically stabilized liposomes. Cancer 73, 2366-2371.
    • (1994) Cancer , vol.73 , pp. 2366-2371
    • Vaage, J.1    Donovan, D.2    Loftus, T.3    Abra, R.4    Working, P.5    Huang, A.6
  • 385
    • 0027131189 scopus 로고
    • Therapy of human ovarian carcinoma xenografts using doxorubicin encapsulated in sterically stabilized liposomes
    • Vaage, J., Donovan, D., Mayhew, E., Abra, R., and Huang, A. (1993) Therapy of human ovarian carcinoma xenografts using doxorubicin encapsulated in sterically stabilized liposomes. Cancer 72, 3671-3675.
    • (1993) Cancer , vol.72 , pp. 3671-3675
    • Vaage, J.1    Donovan, D.2    Mayhew, E.3    Abra, R.4    Huang, A.5
  • 386
    • 0028219430 scopus 로고
    • Tissue distribution and therapeutic effect of intravenous free or encapsulated liposomal doxorubicin on human prostate carcinoma xenografts
    • Vaage, J., Barbera-Guillem, E., Abra, R., Huang, A., and Working, P. (1994) Tissue distribution and therapeutic effect of intravenous free or encapsulated liposomal doxorubicin on human prostate carcinoma xenografts. Cancer 73, 1478-1484.
    • (1994) Cancer , vol.73 , pp. 1478-1484
    • Vaage, J.1    Barbera-Guillem, E.2    Abra, R.3    Huang, A.4    Working, P.5
  • 387
    • 0026733476 scopus 로고
    • Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice
    • Huang, S. C., Lee, K. D., Friend, D. S., and Papahadjopoulos, D. (1992) Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice. Cancer Res. 52, 5135-5143.
    • (1992) Cancer Res. , vol.52 , pp. 5135-5143
    • Huang, S.C.1    Lee, K.D.2    Friend, D.S.3    Papahadjopoulos, D.4
  • 389
    • 0019964477 scopus 로고
    • Improved regional selectivity of hepatic arterial BCNU with degradable microspheres
    • Dakhil, S., Ensminger, W., Cho, K., Neiderhuber, J., Doan, K., and Wheeler, R. (1982) Improved regional selectivity of hepatic arterial BCNU with degradable microspheres. Cancer 50, 631-635.
    • (1982) Cancer , vol.50 , pp. 631-635
    • Dakhil, S.1    Ensminger, W.2    Cho, K.3    Neiderhuber, J.4    Doan, K.5    Wheeler, R.6
  • 390
    • 0025109875 scopus 로고
    • Drug targeting in cancer chemotherapy: A clinical perspective
    • Gupta, P. K. (1990) Drug targeting in cancer chemotherapy: a clinical perspective. J. Pharm. Sci. 79, 949-962.
    • (1990) J. Pharm. Sci. , vol.79 , pp. 949-962
    • Gupta, P.K.1
  • 392
    • 0019432362 scopus 로고
    • Transcatheter arterial chemoembolization of renal cell carcinoma with microencapsulated mitomycin C
    • Kato, T., Nemoto, R., Mori, H., Takahashi, M., and Tamakawa, Y. (1981) Transcatheter arterial chemoembolization of renal cell carcinoma with microencapsulated mitomycin C. J. Urol. 125, 19-24.
    • (1981) J. Urol. , vol.125 , pp. 19-24
    • Kato, T.1    Nemoto, R.2    Mori, H.3    Takahashi, M.4    Tamakawa, Y.5
  • 393
    • 0019462525 scopus 로고
    • Evaluation of therapeutic arterial embolization in renal cell carcinoma using microencapsulated mitomycin C
    • Nemoto, R., Kato, T., Iwata, K., Mori, H., and Takahashi, M. (1981) Evaluation of therapeutic arterial embolization in renal cell carcinoma using microencapsulated mitomycin C. Urology 17, 315-319.
    • (1981) Urology , vol.17 , pp. 315-319
    • Nemoto, R.1    Kato, T.2    Iwata, K.3    Mori, H.4    Takahashi, M.5
  • 394
    • 0028006287 scopus 로고
    • Inhibitory effect of somatostatin analogue RC-160 and bombesin/gastrin-releasing peptide antagonist RC-3095 on the growth of the androgen-independent Dunning R-3327-AT-1 rat prostate cancer
    • Pinski, J., Reile, H., Halmos, G., Groot, K., and Schally, A. V. (1994) Inhibitory effect of somatostatin analogue RC-160 and bombesin/gastrin-releasing peptide antagonist RC-3095 on the growth of the androgen-independent Dunning R-3327-AT-1 rat prostate cancer. Cancer Res. 54, 169-174.
    • (1994) Cancer Res. , vol.54 , pp. 169-174
    • Pinski, J.1    Reile, H.2    Halmos, G.3    Groot, K.4    Schally, A.V.5
  • 395
    • 0026736096 scopus 로고
    • Effect of microcapsules of luteinizing hormone-releasing hormone antagonist SB-75 and somatostatin analogue RC-160 on endocrine status and tumor growth in the Dunning R-3327H rat prostate cancer model
    • Yano, T., Pinski, J., Szepeshazi, K., Milovanovic, S. R., Groot, K., and Schally, A. V. (1992) Effect of microcapsules of luteinizing hormone-releasing hormone antagonist SB-75 and somatostatin analogue RC-160 on endocrine status and tumor growth in the Dunning R-3327H rat prostate cancer model. Prostate 20, 297-310.
    • (1992) Prostate , vol.20 , pp. 297-310
    • Yano, T.1    Pinski, J.2    Szepeshazi, K.3    Milovanovic, S.R.4    Groot, K.5    Schally, A.V.6
  • 397
    • 0031417755 scopus 로고    scopus 로고
    • Enhanced antitumor efficacy of methotrexate poly-(lactic-co-glycolic) acid injectable gel implants in mice bearing sarcoma-180
    • Singh, U. V., Udupa, N., Kamath, R., and Umadevi, P. (1997) Enhanced antitumor efficacy of methotrexate poly-(lactic-co-glycolic) acid injectable gel implants in mice bearing sarcoma-180. Pharm. Sci. 3, 133-136.
    • (1997) Pharm. Sci. , vol.3 , pp. 133-136
    • Singh, U.V.1    Udupa, N.2    Kamath, R.3    Umadevi, P.4
  • 399
    • 0029901366 scopus 로고    scopus 로고
    • Parental protein delivery systems using biodegradable polyesters of ABA block structure, containing hydrophobic poly(lactide-co-glycolide) A blocks and hydrophilic poly-(ethylene oxide) B blocks
    • Kissel, T., Li, Y. X., Volland, C., Gorich, S., and Koneberg, R. (1996) Parental protein delivery systems using biodegradable polyesters of ABA block structure, containing hydrophobic poly(lactide-co-glycolide) A blocks and hydrophilic poly-(ethylene oxide) B blocks. J. Controlled Release 39, 315-326.
    • (1996) J. Controlled Release , vol.39 , pp. 315-326
    • Kissel, T.1    Li, Y.X.2    Volland, C.3    Gorich, S.4    Koneberg, R.5
  • 400
    • 0031238967 scopus 로고    scopus 로고
    • Biodegradable polymeric microparticles for drug delivery and vaccine formulation: The surface attachment of hydrophilic species using the concept of poly(ethylene glycol) anchoring segments
    • Coombes, A. G. A., Tasker, S., Lindblad, M., Holmgren, J., Hoste, K., Toncheva, V., Schacht, E., Davies, M. C., Illum, L., and Davis, S. S. (1997) Biodegradable polymeric microparticles for drug delivery and vaccine formulation: the surface attachment of hydrophilic species using the concept of poly(ethylene glycol) anchoring segments. Biomaterials 18, 1153-1161.
    • (1997) Biomaterials , vol.18 , pp. 1153-1161
    • Coombes, A.G.A.1    Tasker, S.2    Lindblad, M.3    Holmgren, J.4    Hoste, K.5    Toncheva, V.6    Schacht, E.7    Davies, M.C.8    Illum, L.9    Davis, S.S.10
  • 402
    • 0344743906 scopus 로고
    • Biodegradable submicroscopic particles containing a biologically active substance and compositions containing them. U.S. Patent 4,329,332
    • Couvreur, P., Roland, M., and Speiser, P. (1982) Biodegradable submicroscopic particles containing a biologically active substance and compositions containing them. U.S. Patent 4,329,332.
    • (1982)
    • Couvreur, P.1    Roland, M.2    Speiser, P.3
  • 404
    • 0022623825 scopus 로고
    • Physicochemical and morphological characterization of polyisobutylcyanoacrylate nanocapsules
    • Rollot, J. M., Couvreur, P., Roblot-Treupel, L., and Puisieux, F. (1986) Physicochemical and morphological characterization of polyisobutylcyanoacrylate nanocapsules. J. Pharm. Sci. 75, 133-165.
    • (1986) J. Pharm. Sci. , vol.75 , pp. 133-165
    • Rollot, J.M.1    Couvreur, P.2    Roblot-Treupel, L.3    Puisieux, F.4
  • 405
    • 0019365076 scopus 로고
    • Development of biodegradable and injectable latices for controlled release of potent drugs
    • Gurny, R., Peppas, N. A., Harrington, D. D., and Banker, G. S. (1981) Development of biodegradable and injectable latices for controlled release of potent drugs. Drug. Dev. Ind. Pharm. 7, 1-25.
    • (1981) Drug. Dev. Ind. Pharm. , vol.7 , pp. 1-25
    • Gurny, R.1    Peppas, N.A.2    Harrington, D.D.3    Banker, G.S.4
  • 406
    • 0022397325 scopus 로고
    • Polylactic acid nanoparticles, a colloidal drug delivery system for lipophilic drugs
    • Krause, H. J., Schwartz, A., and Rohdelwald, P. (1985) Polylactic acid nanoparticles, a colloidal drug delivery system for lipophilic drugs. Int. J. Pharm. 27, 145-155.
    • (1985) Int. J. Pharm. , vol.27 , pp. 145-155
    • Krause, H.J.1    Schwartz, A.2    Rohdelwald, P.3
  • 407
    • 0016214759 scopus 로고
    • Albumin microspheres as vehicles for achieving specificity in drug delivery
    • Kramer, P. A. (1974) Albumin microspheres as vehicles for achieving specificity in drug delivery. J. Pharm. Sci. 63, 1646-1647.
    • (1974) J. Pharm. Sci. , vol.63 , pp. 1646-1647
    • Kramer, P.A.1
  • 408
    • 0344743905 scopus 로고
    • Procede de preparation des systemes colloidaux dispersibles d'une substance sous forme de nanocapsules (Procedure for the preparation of dispersable colloidal systems of a substance in the form of nanocapsules). Fr. Pat. Appl. 8,-618,446
    • Fessi, H., Devissaguet, J. P., Puisieux, F., and Thies, C. (1986) Procede de preparation des systemes colloidaux dispersibles d'une substance sous forme de nanocapsules (Procedure for the preparation of dispersable colloidal systems of a substance in the form of nanocapsules). Fr. Pat. Appl. 8,-618,446.
    • (1986)
    • Fessi, H.1    Devissaguet, J.P.2    Puisieux, F.3    Thies, C.4
  • 409
    • 0017910704 scopus 로고
    • Nanoparticles: A new colloidal drug delivery system
    • Marty, J. J., Oppenheim, R. C., and Speiser, P. (1978) Nanoparticles: a new colloidal drug delivery system. Pharm. Acta Helv. 53, 17-22.
    • (1978) Pharm. Acta Helv. , vol.53 , pp. 17-22
    • Marty, J.J.1    Oppenheim, R.C.2    Speiser, P.3
  • 410
    • 0345174010 scopus 로고
    • Procede de preparation des systemes colloidaux dispersibles d'une protein sous forme de nanoparticles (Procedure for the preparation of dispersable colloidal systems of a protein in the form of nanoparticles). First Addition to Fr. Pat. Appl. 8,618,446
    • Stainmesse, S., Fessi, H., Devissaguet, J. P., and Puisieux, F. (1988) Procede de preparation des systemes colloidaux dispersibles d'une protein sous forme de nanoparticles (Procedure for the preparation of dispersable colloidal systems of a protein in the form of nanoparticles). First Addition to Fr. Pat. Appl. 8,618,446.
    • (1988)
    • Stainmesse, S.1    Fessi, H.2    Devissaguet, J.P.3    Puisieux, F.4
  • 411
    • 84984083424 scopus 로고
    • Interfacial turbulence: Hydrodynamic instability and Marangoni effect
    • Sterling, C. V., and Scriven, L. E. (1959) Interfacial turbulence: hydrodynamic instability and Marangoni effect. AIChE J. 5, 514-523.
    • (1959) AIChE J. , vol.5 , pp. 514-523
    • Sterling, C.V.1    Scriven, L.E.2
  • 412
    • 0344311575 scopus 로고
    • Procede de preparation des systemes colloidaux dispersibles d'une substance sous forme de nanocapsules (Procedure for the preparation of dispersable colloidal systems of a substance in the form of nanocapsules). Fr. Pat. Appl. 8,618,444
    • Fessi, H., Devissaguet, J. P., and Puisieux F. (1986) Procede de preparation des systemes colloidaux dispersibles d'une substance sous forme de nanocapsules (Procedure for the preparation of dispersable colloidal systems of a substance in the form of nanocapsules). Fr. Pat. Appl. 8,618,444.
    • (1986)
    • Fessi, H.1    Devissaguet, J.P.2    Puisieux, F.3
  • 413
    • 0030575715 scopus 로고    scopus 로고
    • Influence of stabilizing agents and preparative variables on the formation of poly(D,L-lactic acid) nanoparticles by an emulsification-diffusion technique
    • Quintanar-Guerrero, D., Fessi, H., Allemann, E., and Doelker, E. (1996) Influence of stabilizing agents and preparative variables on the formation of poly(D,L-lactic acid) nanoparticles by an emulsification-diffusion technique. Int. J. Pharm. 143, 133-141.
    • (1996) Int. J. Pharm. , vol.143 , pp. 133-141
    • Quintanar-Guerrero, D.1    Fessi, H.2    Allemann, E.3    Doelker, E.4
  • 414
    • 0019957083 scopus 로고
    • Toxicity of polyalkyl-cyanoacrylate nanoparticles. II. Doxorubicin-loaded nanoparticles
    • Couvreur, P., Kante, B., Grislain, L., Roland M., and Speiser, P. (1982) Toxicity of polyalkyl-cyanoacrylate nanoparticles. II. Doxorubicin-loaded nanoparticles. J. Pharm. Sci. 71, 790-792.
    • (1982) J. Pharm. Sci. , vol.71 , pp. 790-792
    • Couvreur, P.1    Kante, B.2    Grislain, L.3    Roland, M.4    Speiser, P.5
  • 415
    • 0025357359 scopus 로고
    • Tissue distribution of doxorubicin associated with polyisohexylcyanoacrylate nanoparticles
    • Verdun, C., Brasseur, F., Vranckx, H., Couvreur, P., and Roland, M. (1990) Tissue distribution of doxorubicin associated with polyisohexylcyanoacrylate nanoparticles. Cancer Chemother. Pharmacol. 26, 13-18.
    • (1990) Cancer Chemother. Pharmacol. , vol.26 , pp. 13-18
    • Verdun, C.1    Brasseur, F.2    Vranckx, H.3    Couvreur, P.4    Roland, M.5
  • 418
    • 0013990549 scopus 로고
    • Studies on the relationship between the electrophoretic properties of colloids and their blood clearance and organ distribution in the rat
    • Wilkins, D. J., and Myers, P. A. (1966) Studies on the relationship between the electrophoretic properties of colloids and their blood clearance and organ distribution in the rat. Br. J. Exp. Pathol. 47, 568-576.
    • (1966) Br. J. Exp. Pathol. , vol.47 , pp. 568-576
    • Wilkins, D.J.1    Myers, P.A.2
  • 419
    • 0029096322 scopus 로고
    • 14C-labeled amino-modified polystyrene nanoparticles in mice
    • 14C-labeled amino-modified polystyrene nanoparticles in mice. J. Pharm. Sci. 84, 1249-1253.
    • (1995) J. Pharm. Sci. , vol.84 , pp. 1249-1253
    • Simon, B.H.1    Ando, H.Y.2    Gupta, P.K.3
  • 420
    • 0023665448 scopus 로고
    • The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a block copolymer-poloxamine 908
    • Illum, L., Davis, S. S., Muller, R. H., Mak, E., and West, P. (1987) The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a block copolymer-poloxamine 908. Life Sci. 40, 367-374.
    • (1987) Life Sci. , vol.40 , pp. 367-374
    • Illum, L.1    Davis, S.S.2    Muller, R.H.3    Mak, E.4    West, P.5
  • 421
    • 0027292348 scopus 로고
    • An investigation of the filtration capacity and the fate of large filtered sterically-stabilized microspheres in rat spleen
    • Moghimi, S. M., Hedeman, H., Muir, I. S., Illum, L., and Davis, S. S. (1993) An investigation of the filtration capacity and the fate of large filtered sterically-stabilized microspheres in rat spleen. Biochim. Biophys. Acta 1157, 233-240.
    • (1993) Biochim. Biophys. Acta , vol.1157 , pp. 233-240
    • Moghimi, S.M.1    Hedeman, H.2    Muir, I.S.3    Illum, L.4    Davis, S.S.5
  • 422
    • 0025778796 scopus 로고
    • Non-phagocitic uptake of intravenously injected microspheres in rat spleen: Influence of particle size and hydrophilic coating
    • Moghimi, S. M., Porter, C. J. H., Muir, I. S., Illum, L., and Davis, S. S. (1991) Non-phagocitic uptake of intravenously injected microspheres in rat spleen: influence of particle size and hydrophilic coating. Biochem. Biophys. Res. Commun. 177, 861-866.
    • (1991) Biochem. Biophys. Res. Commun. , vol.177 , pp. 861-866
    • Moghimi, S.M.1    Porter, C.J.H.2    Muir, I.S.3    Illum, L.4    Davis, S.S.5
  • 423
    • 0026692087 scopus 로고
    • The polyoxyethylene/polyoxypropylene block copolymer poloxamer-407 selectively redirects intravenously injected microspheres to sinusoidal endothelial cells of rabbit bone marrow
    • Porter, C. J. H., Moghimi, S. M., Illum, L., and Davis S. S. (1992) The polyoxyethylene/polyoxypropylene block copolymer poloxamer-407 selectively redirects intravenously injected microspheres to sinusoidal endothelial cells of rabbit bone marrow. FEBS Lett. 305, 62-67.
    • (1992) FEBS Lett. , vol.305 , pp. 62-67
    • Porter, C.J.H.1    Moghimi, S.M.2    Illum, L.3    Davis, S.S.4
  • 424
    • 0027763483 scopus 로고
    • Enhanced hepatic clearance of intravenously administered sterically stabilized microspheres in zymosan-stimulated rats
    • Moghimi, S. M., Hedeman, H., Christy, N. M., Illum, L., and Davis, S. S. (1993) Enhanced hepatic clearance of intravenously administered sterically stabilized microspheres in zymosan-stimulated rats. J. Leukocyte Biol 54, 513-517.
    • (1993) J. Leukocyte Biol , vol.54 , pp. 513-517
    • Moghimi, S.M.1    Hedeman, H.2    Christy, N.M.3    Illum, L.4    Davis, S.S.5
  • 425
    • 0023130497 scopus 로고
    • Surface characteristics and the interaction of colloidal particles with mouse peritoneal macrophages
    • Illum, L., Jacobsen, L. O., Muller, R. H., Mak, E., and Davis, S. S. (1987) Surface characteristics and the interaction of colloidal particles with mouse peritoneal macrophages. Biomaterials 8, 113-117.
    • (1987) Biomaterials , vol.8 , pp. 113-117
    • Illum, L.1    Jacobsen, L.O.2    Muller, R.H.3    Mak, E.4    Davis, S.S.5
  • 427
    • 0024423093 scopus 로고
    • Differential properties of organ-specific serum opsonins for liver and spleen macrophages
    • Moghimi, S. M., and Patel, H. M. (1989) Differential properties of organ-specific serum opsonins for liver and spleen macrophages. Biochim. Biophys. Acta 984, 379-383.
    • (1989) Biochim. Biophys. Acta , vol.984 , pp. 379-383
    • Moghimi, S.M.1    Patel, H.M.2
  • 428
    • 0026541171 scopus 로고
    • Serum opsonins and liposomes: Their interaction and opsonophagocytosis
    • Patel, H. M. (1992) Serum opsonins and liposomes: their interaction and opsonophagocytosis. Crit. Rev. Ther. Drug Carrier Syst. 9, 39-90.
    • (1992) Crit. Rev. Ther. Drug Carrier Syst. , vol.9 , pp. 39-90
    • Patel, H.M.1
  • 429
    • 0026173099 scopus 로고
    • Participation of D-galactose-specific receptors of liver macrophages in recognition of fibronectin-opsonized particles
    • Kolb-Bachofen, V., and Abel, F. (1991) Participation of D-galactose-specific receptors of liver macrophages in recognition of fibronectin-opsonized particles. Carbohydr. Res. 213, 201-213.
    • (1991) Carbohydr. Res. , vol.213 , pp. 201-213
    • Kolb-Bachofen, V.1    Abel, F.2
  • 430
    • 0015839989 scopus 로고
    • Inhibition of phagocytosis: Effect of normal rabbit serum on E. coli uptake by rabbit alveolar macrophages
    • Ulrich, F., and Meier, F. M. (1973) Inhibition of phagocytosis: effect of normal rabbit serum on E. coli uptake by rabbit alveolar macrophages. J. Reticuloendothel. Soc. 14, 8-17.
    • (1973) J. Reticuloendothel. Soc. , vol.14 , pp. 8-17
    • Ulrich, F.1    Meier, F.M.2
  • 431
    • 0024461102 scopus 로고
    • Serum opsonins and phagocytosis of saturated and unsaturated phospholipid liposomes
    • Moghimi, S. M., and Patel, H. M. (1989) Serum opsonins and phagocytosis of saturated and unsaturated phospholipid liposomes. Biochim. Biophys. Acta 984, 384-387.
    • (1989) Biochim. Biophys. Acta , vol.984 , pp. 384-387
    • Moghimi, S.M.1    Patel, H.M.2
  • 432
    • 0025755411 scopus 로고
    • The effect of blood on the uptake of liposomal lipid by perfused rat
    • Nicholas, A. R., and Jones, N. M. (1991) The effect of blood on the uptake of liposomal lipid by perfused rat. Biochim. Biophys. Acta 1074, 105-111.
    • (1991) Biochim. Biophys. Acta , vol.1074 , pp. 105-111
    • Nicholas, A.R.1    Jones, N.M.2
  • 433
    • 0027491769 scopus 로고
    • Coating particles with a block co-polymer (poloxamine-908) suppresses opsonization but permits the activity of dysopsonins in the serum
    • Moghimi, S. M., Muir, I. S., Illum, L., Davis, S. S., and Kolb-Bachofen, V. (1993) Coating particles with a block co-polymer (poloxamine-908) suppresses opsonization but permits the activity of dysopsonins in the serum. Biochim. Biophys. Acta 1179, 157-165.
    • (1993) Biochim. Biophys. Acta , vol.1179 , pp. 157-165
    • Moghimi, S.M.1    Muir, I.S.2    Illum, L.3    Davis, S.S.4    Kolb-Bachofen, V.5
  • 434
    • 0020162411 scopus 로고
    • Electron microscopic evidence for an asialoglycoprotein receptor on Kupffer cells: Localization of lectin-mediated endocytosis
    • Kolb-Bachofen, V., Schlepper-Schafer, J., Vogell, W., and Kolb, H. (1982) Electron microscopic evidence for an asialoglycoprotein receptor on Kupffer cells: localization of lectin-mediated endocytosis. Cell 29, 859-866.
    • (1982) Cell , vol.29 , pp. 859-866
    • Kolb-Bachofen, V.1    Schlepper-Schafer, J.2    Vogell, W.3    Kolb, H.4
  • 435
    • 0026454171 scopus 로고
    • Uptake of toxic silica particles by isolated rat liver macrophages (Kupffer cells) is receptor mediated and can be blocked by competition
    • Kolb-Bachofen, V. (1992) Uptake of toxic silica particles by isolated rat liver macrophages (Kupffer cells) is receptor mediated and can be blocked by competition. J. Clin. Invest. 90, 1819-1824.
    • (1992) J. Clin. Invest. , vol.90 , pp. 1819-1824
    • Kolb-Bachofen, V.1
  • 437
    • 0030969060 scopus 로고    scopus 로고
    • Preparation of biodegradable, surface engineered PLGA nanospheres with enhanced lymphatic drainage and lymph node uptake
    • Hawley, A. E., Illum, L., and Davis, S. S. (1997) Preparation of biodegradable, surface engineered PLGA nanospheres with enhanced lymphatic drainage and lymph node uptake. Pharm. Res. 14, 657-661.
    • (1997) Pharm. Res. , vol.14 , pp. 657-661
    • Hawley, A.E.1    Illum, L.2    Davis, S.S.3
  • 440
    • 0031238529 scopus 로고    scopus 로고
    • Long circulating biodegradable poly(phosphazene) nanoparticles surface modified with poly(phosphazene)-poly-(ethyleneoxide) copolymer
    • Vandorpe, J., Schacht, E., Dunn, S., Hawley, A., Stolnik, S., Davis, S. S., Garnett, M. C., Davies, M. C., and Illum, L. (1997) Long circulating biodegradable poly(phosphazene) nanoparticles surface modified with poly(phosphazene)-poly-(ethyleneoxide) copolymer. Biomaterials 18, 1147-1152.
    • (1997) Biomaterials , vol.18 , pp. 1147-1152
    • Vandorpe, J.1    Schacht, E.2    Dunn, S.3    Hawley, A.4    Stolnik, S.5    Davis, S.S.6    Garnett, M.C.7    Davies, M.C.8    Illum, L.9
  • 441
    • 0020563794 scopus 로고
    • The preparation and properties of sterile intravenous emulsions
    • Hansrani, P. K., Davis, S. S., and Groves, M. J. (1983) The preparation and properties of sterile intravenous emulsions. J. Parenter. Sci. Technol. 37, 145-150.
    • (1983) J. Parenter. Sci. Technol. , vol.37 , pp. 145-150
    • Hansrani, P.K.1    Davis, S.S.2    Groves, M.J.3
  • 443
    • 0022622551 scopus 로고
    • Parental emulsions as drug carrier system
    • Singh, M., and Ravin, L. J. (1986) Parental emulsions as drug carrier system. J. Parenter. Sci. Technol. 40, 34-41.
    • (1986) J. Parenter. Sci. Technol. , vol.40 , pp. 34-41
    • Singh, M.1    Ravin, L.J.2
  • 444
    • 0020049344 scopus 로고
    • Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery
    • Poste, G., Bucana, C., Raz, A., Bugelski, P., Kirsh, R., and Fidler, I. J. (1982) Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery. Cancer Res. 42, 1412-1422.
    • (1982) Cancer Res. , vol.42 , pp. 1412-1422
    • Poste, G.1    Bucana, C.2    Raz, A.3    Bugelski, P.4    Kirsh, R.5    Fidler, I.J.6
  • 446
    • 0029048759 scopus 로고
    • Long-circulating emulsions (oil-in-water) as carriers for lipophilic drugs
    • Liu, F., and Liu, D. (1995) Long-circulating emulsions (oil-in-water) as carriers for lipophilic drugs. Pharmacol. Res. 12, 1060-1064.
    • (1995) Pharmacol. Res. , vol.12 , pp. 1060-1064
    • Liu, F.1    Liu, D.2
  • 447
    • 0031033405 scopus 로고    scopus 로고
    • A submicron lipid emulsion coated with amphipathic polyethylene glycol for parental administration of Paclitaxel (Taxol)
    • Lundberg, B. (1997) A submicron lipid emulsion coated with amphipathic polyethylene glycol for parental administration of Paclitaxel (Taxol). J. Pharm. Pharmacol. 49, 16-21.
    • (1997) J. Pharm. Pharmacol. , vol.49 , pp. 16-21
    • Lundberg, B.1
  • 451
    • 0030095150 scopus 로고    scopus 로고
    • Stable polymeric micelles: Lymphangiographic contrast media for gamma scintigraphy and magnetic resonance imaging
    • Trubetskoy, V. S., Frank-Kamenetsky, M. D., Whiteman, K. R., Wolf, G. L., and Torchilin, V. P. (1996) Stable polymeric micelles: lymphangiographic contrast media for gamma scintigraphy and magnetic resonance imaging. Acad. Radiol. 3, 232-238.
    • (1996) Acad. Radiol. , vol.3 , pp. 232-238
    • Trubetskoy, V.S.1    Frank-Kamenetsky, M.D.2    Whiteman, K.R.3    Wolf, G.L.4    Torchilin, V.P.5
  • 452
    • 0030964836 scopus 로고    scopus 로고
    • Pharmacokinetic considerations in the development of labeled liposomes and micelles for diagnostic imaging
    • Torchilin, V. P. (1997) Pharmacokinetic considerations in the development of labeled liposomes and micelles for diagnostic imaging. Q. J. Nucl. Med. 41, 141-153.
    • (1997) Q. J. Nucl. Med. , vol.41 , pp. 141-153
    • Torchilin, V.P.1
  • 453
    • 0028258088 scopus 로고
    • Control of the disposition profiles of proteins in the kidney via chemical modification
    • Takakura, Y., Mihara, K., and Hashida, M. (1994) Control of the disposition profiles of proteins in the kidney via chemical modification. J. Controlled Release 28, 111-119.
    • (1994) J. Controlled Release , vol.28 , pp. 111-119
    • Takakura, Y.1    Mihara, K.2    Hashida, M.3
  • 454
    • 0027247458 scopus 로고
    • From somatostatin to sandostatin: Pharmacodynamics and pharmacokinetics
    • Marbach, P., Briner, U., Lemaire, M., Schweitzer, A. and Terasaki, T. (1993) From somatostatin to sandostatin: pharmacodynamics and pharmacokinetics. Digestion 54, 9-13.
    • (1993) Digestion , vol.54 , pp. 9-13
    • Marbach, P.1    Briner, U.2    Lemaire, M.3    Schweitzer, A.4    Terasaki, T.5
  • 456
    • 0025978976 scopus 로고
    • Man-made antibodies
    • Winter, G., and Miolstein, C. (1991) Man-made antibodies. Nature 349, 293-299.
    • (1991) Nature , vol.349 , pp. 293-299
    • Winter, G.1    Miolstein, C.2
  • 457
    • 0025162270 scopus 로고
    • A comparison of strategies to stalibilize immunoglobulin Fv fragments
    • Glockshuber, R., Malia, M., Pfitzinger, I., and Pluckthum, A. (1990) A comparison of strategies to stalibilize immunoglobulin Fv fragments. Biochemistry 29, 1362-1367.
    • (1990) Biochemistry , vol.29 , pp. 1362-1367
    • Glockshuber, R.1    Malia, M.2    Pfitzinger, I.3    Pluckthum, A.4
  • 458
    • 0026772358 scopus 로고
    • Comparative stabilities in vitro and in vivo of a recombinant mouse antibody FvCys fragment and a bisFvCys conjugate
    • Cumber, A. J., Ward, E. S., Winter, G., Parnell, G. D., and Wawrzynczak, J. (1992) Comparative stabilities in vitro and in vivo of a recombinant mouse antibody FvCys fragment and a bisFvCys conjugate. J. Immunol. 149, 120-126
    • (1992) J. Immunol. , vol.149 , pp. 120-126
    • Cumber, A.J.1    Ward, E.S.2    Winter, G.3    Parnell, G.D.4    Wawrzynczak, J.5
  • 459
    • 0026684815 scopus 로고
    • Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms
    • Yokota, T., Milenic, D. E., Withlow, M., and Scholm, J. (1992) Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms. Cancer Res. 52, 3402-3408.
    • (1992) Cancer Res. , vol.52 , pp. 3402-3408
    • Yokota, T.1    Milenic, D.E.2    Withlow, M.3    Scholm, J.4
  • 460
    • 0028275863 scopus 로고
    • Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment
    • Reiter, Y., Pai, L. H., Brinkmann, U. Wang, Q., and Pastan, I. (1994) Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment. Cancer Res. 54, 2714-2718.
    • (1994) Cancer Res. , vol.54 , pp. 2714-2718
    • Reiter, Y.1    Pai, L.H.2    Brinkmann, U.3    Wang, Q.4    Pastan, I.5
  • 461
    • 0027936805 scopus 로고
    • Evaluation of technetium-99m exametazime stabilised with cobalt chloride as a blood flow tacer in focal cerebral ischemia
    • Gartshore, G., Bannan, P., Patterson, J., Highley, B., and McCulloch, J. (1994) Evaluation of technetium-99m exametazime stabilised with cobalt chloride as a blood flow tacer in focal cerebral ischemia. Eur. J. Nucl. Med. 21, 913-923.
    • (1994) Eur. J. Nucl. Med. , vol.21 , pp. 913-923
    • Gartshore, G.1    Bannan, P.2    Patterson, J.3    Highley, B.4    McCulloch, J.5
  • 462
    • 0024835606 scopus 로고
    • 99mTc-HPMAO): Basic kinetic studies of a tracer of cerebral blood flow
    • 99mTc-HPMAO): basic kinetic studies of a tracer of cerebral blood flow. Cerebrovasc. Brain Metab. Rev. 1, 288-318.
    • (1989) Cerebrovasc. Brain Metab. Rev. , vol.1 , pp. 288-318
    • Andersen, A.R.1
  • 466
    • 0027984165 scopus 로고
    • Lecithinized superoxide dismutase enhances its pharmacologic potency by increasing its cell membrane affinity
    • Igarashi, R., Hoshino, J., Ochiai, A., Morizawa, Y., and Mizushima, Y. (1994) Lecithinized superoxide dismutase enhances its pharmacologic potency by increasing its cell membrane affinity. J. Pharmacol. Exp. Ther. 271, 1672-1677.
    • (1994) J. Pharmacol. Exp. Ther. , vol.271 , pp. 1672-1677
    • Igarashi, R.1    Hoshino, J.2    Ochiai, A.3    Morizawa, Y.4    Mizushima, Y.5
  • 468
    • 0027941981 scopus 로고
    • Enhanced permeability of tetragastrin across the rat intestinal membrane and its reduced degradation by acylation with various fatty acids
    • Todoya, E., Uemura, K., Tenma, T., Fujita, T., Murakami, M., Yamamoto, A., and Muranishi, S. (1994) Enhanced permeability of tetragastrin across the rat intestinal membrane and its reduced degradation by acylation with various fatty acids. J. Pharmacol. Exp. Ther. 271, 1509-1513.
    • (1994) J. Pharmacol. Exp. Ther. , vol.271 , pp. 1509-1513
    • Todoya, E.1    Uemura, K.2    Tenma, T.3    Fujita, T.4    Murakami, M.5    Yamamoto, A.6    Muranishi, S.7
  • 469
    • 0029857980 scopus 로고    scopus 로고
    • Comparison of pharmacokinetic parameters of a polypeptide, the Bowman-Birk protease inhibitor (BBI), and its palmitic acid conjugate
    • Honeycutt, L. R., Wang, J., Ekrami, H., and Shen, W. C. (1996) Comparison of pharmacokinetic parameters of a polypeptide, the Bowman-Birk protease inhibitor (BBI), and its palmitic acid conjugate. Pharm. Res. 13, 1373-1377.
    • (1996) Pharm. Res. , vol.13 , pp. 1373-1377
    • Honeycutt, L.R.1    Wang, J.2    Ekrami, H.3    Shen, W.C.4
  • 471
    • 0030198459 scopus 로고    scopus 로고
    • Influence of counter ions on the skin permeation of methotrexate from water-oil microemulsions
    • Trotta, M., Pattarino, F., and Gasco, M. R. (1996) Influence of counter ions on the skin permeation of methotrexate from water-oil microemulsions. Pharm. Acta Helv. 71, 135-140.
    • (1996) Pharm. Acta Helv. , vol.71 , pp. 135-140
    • Trotta, M.1    Pattarino, F.2    Gasco, M.R.3
  • 473
    • 0001578794 scopus 로고
    • Acid functionalized amphiphiles derived from polystyrene-polypropylene imine dendrimers, with a pH dependent aggregation
    • van Hest, J. C. M., Baars, M. W. P. L., Elissen-Roman, C., van Genderen, M. H. P., and Meijer, E. W. (1995) Acid functionalized amphiphiles derived from polystyrene-polypropylene imine) dendrimers, with a pH dependent aggregation. Macromolecules 28, 6689-6691.
    • (1995) Macromolecules , vol.28 , pp. 6689-6691
    • Van Hest, J.C.M.1    Baars, M.W.P.L.2    Elissen-Roman, C.3    Van Genderen, M.H.P.4    Meijer, E.W.5
  • 474
    • 0030926147 scopus 로고    scopus 로고
    • Characterization of complexes of oligonucleotides with polyamidoamine starburst dendrimers and effects on intracellular delivery
    • DeLong, R., Stephenson, K., Loftus, T., Fisher, M., Alahari, S., Nelting, A., and Juliano, R. L. (1997) Characterization of complexes of oligonucleotides with polyamidoamine starburst dendrimers and effects on intracellular delivery. J. Pharm. Sci. 86, 762-764.
    • (1997) J. Pharm. Sci. , vol.86 , pp. 762-764
    • DeLong, R.1    Stephenson, K.2    Loftus, T.3    Fisher, M.4    Alahari, S.5    Nelting, A.6    Juliano, R.L.7
  • 475
    • 0031408036 scopus 로고    scopus 로고
    • Inclusion complexation of unstable guests with cyclodextrins: Improved kinetic studies for calculation of the binding constants in guest-cyclodextrin systems
    • Loukas, Y. L. (1997) Inclusion complexation of unstable guests with cyclodextrins: improved kinetic studies for calculation of the binding constants in guest-cyclodextrin systems.Pharm. Sci. 3, 343-346.
    • (1997) Pharm. Sci. , vol.3 , pp. 343-346
    • Loukas, Y.L.1
  • 477
    • 0022526685 scopus 로고
    • Calcium-induced alterations in the levels and subcellular distribution of proteolytic enzymes in human red blood cells
    • Grasso, M., Morelli, A., and De Flora, A. (1986) Calcium-induced alterations in the levels and subcellular distribution of proteolytic enzymes in human red blood cells. Biochem. Biophys. Res. Commun. 138, 87-94.
    • (1986) Biochem. Biophys. Res. Commun. , vol.138 , pp. 87-94
    • Grasso, M.1    Morelli, A.2    De Flora, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.