-
1
-
-
84889414582
-
Mechanisms of adjuvant action
-
(Singh, M., ed), (John Wiley & Sons, Hoboken, NJ
-
Lycke, N. Mechanisms of adjuvant action. In Vaccine Adjuvants and Delivery Systems (Singh, M., ed) 53-79 (John Wiley & Sons, Hoboken, NJ, 2007).
-
(2007)
Vaccine Adjuvants and Delivery Systems
, pp. 53-79
-
-
Lycke, N.1
-
2
-
-
2442641456
-
Vaccine development strategies for improving immunization: The role of modern immunology
-
Levine, M. M. & Sztein, M. B. Vaccine development strategies for improving immunization: the role of modern immunology. Nat. Immunol. 5, 460-464 (2004).
-
(2004)
Nat. Immunol.
, vol.5
, pp. 460-464
-
-
Levine, M.M.1
Sztein, M.B.2
-
3
-
-
0034802541
-
Signatures of the immune response
-
Shaffer, A. L. et al. Signatures of the immune response. Immunity 15, 375-385 (2001).
-
(2001)
Immunity
, vol.15
, pp. 375-385
-
-
Shaffer, A.L.1
-
4
-
-
0036832351
-
Opinion: Interpretation of the complexity of innate immune responses by functional genomics
-
Ricciardi-Castagnoli, P. & Granucci, F. Opinion: interpretation of the complexity of innate immune responses by functional genomics. Nat. Rev. Immunol. 2, 881-889 (2002).
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 881-889
-
-
Ricciardi-Castagnoli, P.1
Granucci, F.2
-
5
-
-
17644371966
-
Mucosal immunity and vaccines
-
Holmgren, J. & Czerkinsky, C. Mucosal immunity and vaccines. Nat. Med. 11, S45-S53 (2005).
-
(2005)
Nat. Med.
, vol.11
-
-
Holmgren, J.1
Czerkinsky, C.2
-
6
-
-
0032748077
-
Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins
-
Rappuoli, R., Pizza, M., Douce, G. & Dougan, G. Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins. Immunol. Today 20, 493-500 (1999).
-
(1999)
Immunol. Today
, vol.20
, pp. 493-500
-
-
Rappuoli, R.1
Pizza, M.2
Douce, G.3
Dougan, G.4
-
7
-
-
0037035853
-
A dilemma for mucosal vaccination: Efficacy versus toxicity using enterotoxin-based adjuvants
-
Fujihashi, K., Koga, T., van Ginkel, F. W., Hagiwara, Y. & McGhee, J. R. A dilemma for mucosal vaccination: effi cacy versus toxicity using enterotoxin-based adjuvants. Vaccine 20, 2431-2438 (2002).
-
(2002)
Vaccine
, vol.20
, pp. 2431-2438
-
-
Fujihashi, K.1
Koga, T.2
Van Ginkel, F.W.3
Hagiwara, Y.4
McGhee, J.R.5
-
8
-
-
49049084123
-
Molecular architecture of signal complexes regulating immune cell function
-
Torgersen, K. M., Aandahl, E. M. & Tasken, K. Molecular architecture of signal complexes regulating immune cell function. Handb. Exp. Pharmacol. 4, 327-363 (2008).
-
(2008)
Handb. Exp. Pharmacol.
, vol.4
, pp. 327-363
-
-
Torgersen, K.M.1
Aandahl, E.M.2
Tasken, K.3
-
9
-
-
33644842604
-
Mucosal adjuvants
-
(Mestecky, J., et al. eds), (Elsevier Academic Press, San Diego, CA
-
Elson, C. O. & Dertzbaugh, M. T. Mucosal adjuvants. In Mucosal Immunology, Vol 1 (Mestecky, J., et al. eds) 967-986 (Elsevier Academic Press, San Diego, CA, 2005).
-
(2005)
Mucosal Immunology
, vol.1
, pp. 967-986
-
-
Elson, C.O.1
Dertzbaugh, M.T.2
-
10
-
-
0025204725
-
Cholera toxin acts synergistically with IL-4 to promote IgG1 switch differentiation
-
Lycke, N., Severinson, E. & Strober, W. Cholera toxin acts synergistically with IL-4 to promote IgG1 switch differentiation. J. Immunol. 145, 3316-3324 (1990).
-
(1990)
J. Immunol.
, vol.145
, pp. 3316-3324
-
-
Lycke, N.1
Severinson, E.2
Strober, W.3
-
11
-
-
26844495178
-
Splenic marginal zone dendritic cells mediate the cholera toxin adjuvant effect: Dependence on the ADP-ribosyltransferase activity of the holotoxin
-
Grdic, D. et al. Splenic marginal zone dendritic cells mediate the cholera toxin adjuvant effect: dependence on the ADP-ribosyltransferase activity of the holotoxin. J. Immunol. 175, 5192-5202 (2005).
-
(2005)
J. Immunol.
, vol.175
, pp. 5192-5202
-
-
Grdic, D.1
-
12
-
-
0035133494
-
Effects of cholera toxin on macrophage production of co-stimulatory cytokines
-
Cong, Y., Oliver, A. O. & Elson, C. O. Effects of cholera toxin on macrophage production of co-stimulatory cytokines. Eur. J. Immunol. 31, 64-71 (2001).
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 64-71
-
-
Cong, Y.1
Oliver, A.O.2
Elson, C.O.3
-
13
-
-
2342450639
-
Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent
-
Lavelle, E. C. et al. Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent. J. Leukoc. Biol. 75, 756-763 (2004).
-
(2004)
J. Leukoc. Biol.
, vol.75
, pp. 756-763
-
-
Lavelle, E.C.1
-
14
-
-
0037435927
-
Maturation of human dendritic cells induced by the adjuvant cholera toxin: Role of cAMP on chemokine receptor expression
-
Gagliardi, M. C. & De Magistris, M. T. Maturation of human dendritic cells induced by the adjuvant cholera toxin: role of cAMP on chemokine receptor expression. Vaccine 21, 856-861 (2003).
-
(2003)
Vaccine
, vol.21
, pp. 856-861
-
-
Gagliardi, M.C.1
De Magistris, M.T.2
-
15
-
-
0033081332
-
Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression
-
Braun, M. C., He, J., Wu, C. Y. & Kelsall, B. L. Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression. J. Exp. Med. 189, 541-552 (1999).
-
(1999)
J. Exp. Med.
, vol.189
, pp. 541-552
-
-
Braun, M.C.1
He, J.2
Wu, C.Y.3
Kelsall, B.L.4
-
16
-
-
30444458235
-
Stats: Multifaceted regulators of transcription
-
Brierley, M. M. & Fish, E. N. Stats: multifaceted regulators of transcription. J. Interferon Cytokine Res. 25, 733-744 (2005).
-
(2005)
J. Interferon Cytokine Res.
, vol.25
, pp. 733-744
-
-
Brierley, M.M.1
Fish, E.N.2
-
17
-
-
32644474195
-
STAT3 in immune responses and infl ammatory bowel diseases
-
Fu, X. Y. STAT3 in immune responses and infl ammatory bowel diseases. Cell Res. 16, 214-219 (2006).
-
(2006)
Cell Res.
, vol.16
, pp. 214-219
-
-
Fu, X.Y.1
-
18
-
-
36348995922
-
Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic infl ammatory response and lethality in septic mice
-
Sakamori, R. et al. Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic infl ammatory response and lethality in septic mice. Hepatology 46, 1564-1573 (2007).
-
(2007)
Hepatology
, vol.46
, pp. 1564-1573
-
-
Sakamori, R.1
-
19
-
-
44449136105
-
Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases
-
Liu, X., Lee, Y. S., Yu, C. R. & Egwuagu, C. E. Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases. J. Immunol. 180, 6070-6076 (2008).
-
(2008)
J. Immunol.
, vol.180
, pp. 6070-6076
-
-
Liu, X.1
Lee, Y.S.2
Yu, C.R.3
Egwuagu, C.E.4
-
20
-
-
38949165127
-
Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas
-
Ding, B. B. et al. Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas. Blood 111, 1515-1523 (2008).
-
(2008)
Blood
, vol.111
, pp. 1515-1523
-
-
Ding, B.B.1
-
21
-
-
31544474862
-
Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells
-
Fornek, J. L. et al. Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells. Blood 107, 1085-1091 (2006).
-
(2006)
Blood
, vol.107
, pp. 1085-1091
-
-
Fornek, J.L.1
-
22
-
-
0035554678
-
Inducible IL-2 production by dendritic cells revealed by global gene expression analysis
-
Granucci, F. et al. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat. Immunol. 2, 882-888 (2001).
-
(2001)
Nat. Immunol.
, vol.2
, pp. 882-888
-
-
Granucci, F.1
-
23
-
-
17144443360
-
Cascades of transcriptional induction during dendritic cell maturation revealed by genome-wide expression analysis
-
Tureci, O. et al. Cascades of transcriptional induction during dendritic cell maturation revealed by genome-wide expression analysis. Faseb. J. 17, 836-847 (2003).
-
(2003)
Faseb. J.
, vol.17
, pp. 836-847
-
-
Tureci, O.1
-
24
-
-
30344484535
-
Cholera toxin induced novel genes in human lymphocytes and monocytes
-
Royaee, A. R. et al. Cholera toxin induced novel genes in human lymphocytes and monocytes. Mol. Immunol. 43, 1267-1274 (2006).
-
(2006)
Mol. Immunol.
, vol.43
, pp. 1267-1274
-
-
Royaee, A.R.1
-
25
-
-
0034658541
-
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
-
Hirano, T., Ishihara, K. & Hibi, M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 19, 2548-2556 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 2548-2556
-
-
Hirano, T.1
Ishihara, K.2
Hibi, M.3
-
26
-
-
34249681852
-
An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity
-
Nishinakamura, H. et al. An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity. Int. Immunol. 19, 609-619 (2007).
-
(2007)
Int. Immunol.
, vol.19
, pp. 609-619
-
-
Nishinakamura, H.1
-
27
-
-
29144524858
-
Induction of immunomodulator transcriptional responses by cholera toxin
-
Royaee, A. R. et al. Induction of immunomodulator transcriptional responses by cholera toxin. Mol. Immunol. 43, 1020-1028 (2006).
-
(2006)
Mol. Immunol.
, vol.43
, pp. 1020-1028
-
-
Royaee, A.R.1
-
28
-
-
38449108512
-
The acquired immune response to the mucosal adjuvant LTK63 imprints the mouse lung with a protective signature
-
Tritto, E. et al. The acquired immune response to the mucosal adjuvant LTK63 imprints the mouse lung with a protective signature. J. Immunol. 179, 5346-5357 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 5346-5357
-
-
Tritto, E.1
-
29
-
-
28944432693
-
Cholera toxin induced gene expression alterations
-
Royaee, A. R., Mendis, C., Das, R., Jett, M. & Yang, D. C. Cholera toxin induced gene expression alterations. Mol. Immunol. 43, 702-709 (2006).
-
(2006)
Mol. Immunol.
, vol.43
, pp. 702-709
-
-
Royaee, A.R.1
Mendis, C.2
Das, R.3
Jett, M.4
Yang, D.C.5
-
30
-
-
0037083339
-
Cholera toxin B pretreatment of macrophages and monocytes diminishes their proinfl ammatory responsiveness to lipopolysaccharide
-
Burkart, V. et al. Cholera toxin B pretreatment of macrophages and monocytes diminishes their proinfl ammatory responsiveness to lipopolysaccharide. J. Immunol. 168, 1730-1737 (2002).
-
(2002)
J. Immunol.
, vol.168
, pp. 1730-1737
-
-
Burkart, V.1
-
31
-
-
45449094567
-
Activation-dependent induction of Blimp-1
-
Calame, K. Activation-dependent induction of Blimp-1. Curr. Opin. Immunol. 20, 259-264 (2008).
-
(2008)
Curr. Opin. Immunol.
, vol.20
, pp. 259-264
-
-
Calame, K.1
-
32
-
-
33745700364
-
Understanding and exploiting the endogenous interleukin-10/ STAT3-mediated anti-infl ammatory response
-
Murray P. J.
-
Murray, P. J. Understanding and exploiting the endogenous interleukin-10/ STAT3-mediated anti-infl ammatory response. Curr. Opin. Pharmacol. 6, 379-386 (2006).
-
(2006)
Curr. Opin. Pharmacol.
, vol.6
, pp. 379-386
-
-
-
33
-
-
0033034365
-
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
-
Takeda, K. et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10, 39-49 (1999).
-
(1999)
Immunity
, vol.10
, pp. 39-49
-
-
Takeda, K.1
-
34
-
-
0346103717
-
Signal transducer and activator of transcription 3 is the dominant mediator of the anti-infl ammatory effects of IL-10 in human macrophages
-
Williams, L., Bradley, L., Smith, A. & Foxwell, B. Signal transducer and activator of transcription 3 is the dominant mediator of the anti-infl ammatory effects of IL-10 in human macrophages. J. Immunol. 172, 567-576 (2004).
-
(2004)
J. Immunol.
, vol.172
, pp. 567-576
-
-
Williams, L.1
Bradley, L.2
Smith, A.3
Foxwell, B.4
-
35
-
-
49149127436
-
STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinfl ammatory cytokine production
-
Owaki, T. et al. STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinfl ammatory cytokine production. J. Immunol. 180, 2903-2911 (2008).
-
(2008)
J. Immunol.
, vol.180
, pp. 2903-2911
-
-
Owaki, T.1
-
36
-
-
34848898431
-
Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-defi cient dendritic cells
-
Matsumura, Y. et al. Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-defi cient dendritic cells. J. Immunol. 179, 2170-2179 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 2170-2179
-
-
Matsumura, Y.1
-
37
-
-
34247122412
-
Stat3 and Stat4 direct development of IL-17-secreting Th cells
-
Mathur, A. N. et al. Stat3 and Stat4 direct development of IL-17-secreting Th cells. J. Immunol. 178, 4901-4907 (2007).
-
(2007)
J. Immunol.
, vol.178
, pp. 4901-4907
-
-
Mathur, A.N.1
-
38
-
-
63849275584
-
Interleukin-6/STAT3 signalling regulates the ability of naive T cells to acquire B cell help capacities
-
Eddahri, F. et al. Interleukin-6/STAT3 signalling regulates the ability of naive T cells to acquire B cell help capacities. Blood 113, 2426-2433 (2009).
-
(2009)
Blood
, vol.113
, pp. 2426-2433
-
-
Eddahri, F.1
-
39
-
-
0019448149
-
Actions of cholera toxin and the prevention and treatment of cholera
-
Holmgren, J. Actions of cholera toxin and the prevention and treatment of cholera. Nature 292, 413-417 (1981).
-
(1981)
Nature
, vol.292
, pp. 413-417
-
-
Holmgren, J.1
-
40
-
-
33846013962
-
Activation of STAT3 by G alpha(s) distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinase
-
Liu, A. M. et al. Activation of STAT3 by G alpha(s) distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinase. J. Biol. Chem. 281, 35812-35825 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 35812-35825
-
-
Liu, A.M.1
-
41
-
-
4644261307
-
The STAT3 isoforms alpha and beta have unique and specifi c functions
-
Maritano, D. et al. The STAT3 isoforms alpha and beta have unique and specifi c functions. Nat. Immunol. 5, 401-409 (2004).
-
(2004)
Nat. Immunol.
, vol.5
, pp. 401-409
-
-
Maritano, D.1
-
42
-
-
52049124749
-
Of alphas and betas: Distinct and overlapping functions of STAT3 isoforms
-
Dewilde, S., Vercelli, A., Chiarle, R. & Poli, V. Of alphas and betas: distinct and overlapping functions of STAT3 isoforms. Front Biosci. 13, 6501-6514 (2008).
-
(2008)
Front Biosci.
, vol.13
, pp. 6501-6514
-
-
Dewilde, S.1
Vercelli, A.2
Chiarle, R.3
Poli, V.4
-
43
-
-
0036256644
-
What does Stat3 do?
-
Levy, D. E. & Lee, C. K. What does Stat3 do? J. Clin. Invest. 109, 1143-1148 (2002).
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1143-1148
-
-
Levy, D.E.1
Lee, C.K.2
-
44
-
-
17144410317
-
Cholera toxin potentiates infl uences of IFN-gamma through activation of NF-kappaB and release of tumor necrosis factor-alpha
-
Blumberg, R. S., Pitman, R. S., Taylor, C. T. & Colgan, S. P. Cholera toxin potentiates infl uences of IFN-gamma through activation of NF-kappaB and release of tumor necrosis factor-alpha. J. Interferon Cytokine Res. 25, 209-219 (2005).
-
(2005)
J. Interferon Cytokine Res.
, vol.25
, pp. 209-219
-
-
Blumberg, R.S.1
Pitman, R.S.2
Taylor, C.T.3
Colgan, S.P.4
-
45
-
-
0018388062
-
And characterization of BALB/c lymphoma lines with B cell properties
-
Kim, K. J., Kanellopoulos-Langevin, C., Merwin, R. M., Sachs, D. H. & Asofsky, R. Establishment and characterization of BALB/c lymphoma lines with B cell properties. J. Immunol. 122, 549-554 (1979).
-
(1979)
J. Immunol.
, vol.122
, pp. 549-554
-
-
Kim, K.J.1
Kanellopoulos-Langevin, C.2
Merwin, R.M.3
Sachs, D.H.4
Establishment, A.R.5
-
46
-
-
0020535737
-
Characterization of T-cell-soluble factors modulating the expression of Ia and H-2 antigens on BALB/c B lymphoma cell lines
-
Kim, K. J., Chaouat, G., Leiserson, W. M., King, J. & De Maeyer, E. Characterization of T-cell-soluble factors modulating the expression of Ia and H-2 antigens on BALB/c B lymphoma cell lines. Cell Immunol. 76, 253-267 (1983).
-
(1983)
Cell Immunol.
, vol.76
, pp. 253-267
-
-
Kim, K.J.1
Chaouat, G.2
Leiserson, W.M.3
King, J.4
De Maeyer, E.5
-
47
-
-
0010687078
-
A molecular approach to the construction of an effective mucosal vaccine adjuvant: Studies based on cholera toxin ADP-ribosylation and cell targeting
-
(Kagnoff, M. & Kiyono, H., eds), (Academic Press Inc, San Diego
-
Lycke, N. A molecular approach to the construction of an effective mucosal vaccine adjuvant: studies based on cholera toxin ADP-ribosylation and cell targeting. In Essentials of Mucosal Immunology (Kagnoff, M. & Kiyono, H., eds) 563-580 (Academic Press Inc, San Diego, 1996).
-
(1996)
Essentials of Mucosal Immunology
, pp. 563-580
-
-
Lycke, N.1
-
48
-
-
33645065850
-
The nontoxic CTA1-DD adjuvant enhances protective immunity against Helicobacter pylori infection following mucosal immunization
-
Akhiani, A. A., Stensson, A., Schon, K. & Lycke, N. The nontoxic CTA1-DD adjuvant enhances protective immunity against Helicobacter pylori infection following mucosal immunization. Scand. J. Immunol. 63, 97-105 (2006).
-
(2006)
Scand. J. Immunol.
, vol.63
, pp. 97-105
-
-
Akhiani, A.A.1
Stensson, A.2
Schon, K.3
Lycke, N.4
-
49
-
-
0027174861
-
Cholera toxin promotes B cell isotype switching by two different mechanisms. cAMP induction augments germ-line Ig H-chain RNA transcripts whereas membrane ganglioside GM1-receptor binding enhances later events in differentiation
-
Lycke, N. Y. Cholera toxin promotes B cell isotype switching by two different mechanisms. cAMP induction augments germ-line Ig H-chain RNA transcripts whereas membrane ganglioside GM1-receptor binding enhances later events in differentiation. J. Immunol. 150, 4810-4821 (1993).
-
(1993)
J. Immunol.
, vol.150
, pp. 4810-4821
-
-
Lycke, N.Y.1
-
50
-
-
0142250491
-
Intracellular location and cell contextdependent function of protein kinase D
-
Marklund, U., Lightfoot, K. & Cantrell, D. Intracellular location and cell contextdependent function of protein kinase D. Immunity 19, 491-501 (2003).
-
(2003)
Immunity
, vol.19
, pp. 491-501
-
-
Marklund, U.1
Lightfoot, K.2
Cantrell, D.3
|