Intranasal administration of adjuvant-combined recombinant influenza virus HA vaccine protects mice from the lethal H5N1 virus infection

Microbes and Infection

Volumn 8, Issue 12-13, 2006, Pages 2706-2714

  Asahi Ozaki, Yasuko ^a   Itamura, Shigeyuki ^a   Ichinohe, Takeshi ^a   Strong, Peter ^b   Tamura, Shin ichi ^a   Takahashi, Hidehiro ^a   Sawa, Hirofumi ^c   Moriyama, Masami ^d   Tashiro, Masato ^a   Sata, Tetsutaro ^a   Kurata, Takeshi ^a   Hasegawa, Hideki ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c HOKKAIDO UNIVERSITY   (Japan)

^d KEIO UNIVERSITY   (Japan)

Author keywords

Adjuvant; Chitin microparticle (CMP); Double stranded RNA (dsRNA); H5N1; IgA; Poly (I:C); Toll like receptor (TLR)

Indexed keywords

CHITIN; CHOLERA TOXIN B SUBUNIT; DOUBLE STRANDED RNA; HEMAGGLUTININ; HOLOTOXIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G ANTIBODY; INFLUENZA VACCINE; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOXIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HUMAN; IMMUNITY; IMMUNOGENICITY; INFLUENZA; INFLUENZA VIRUS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN; VIRUS RECOMBINANT;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, VIRAL; CHITIN; CHOLERA TOXIN; DISEASE MODELS, ANIMAL; FEMALE; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA VACCINES; LYMPHOID TISSUE; MICE; MICE, INBRED BALB C; MICROSPHERES; NASAL MUCOSA; ORTHOMYXOVIRIDAE INFECTIONS; POLY I-C; RNA, DOUBLE-STRANDED; SPLEEN; TOLL-LIKE RECEPTORS; VACCINES, SUBUNIT; VACCINES, SYNTHETIC;

ORTHOMYXOVIRIDAE;

EID: 33750624337     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2006.07.018     Document Type: Article

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