Side effects associated with influenza vaccination in healthy working adults: A randomized, placebo-controlled trial

Archives of Internal Medicine

Volumn 156, Issue 14, 1996, Pages 1546-1550

  Nichol, Kristin L ^a,c   Margolis, Karen L ^b,c   Lind, April ^a,c   Murdoch, Maureen ^a,c   McFadden, Rodney ^b,c   Hauge, Meri ^a   Magnan, Sanne ^c,d   Drake, Mari ^e  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b HENNEPIN COUNTY MEDICAL CENTER   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d Blue Cross Blue Shield of Minnesota   (United States)

^e American Lung Association   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VACCINE; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG INDUCED DISEASE; FATIGUE; FEMALE; FEVER; HEADACHE; HUMAN; INFECTION PREVENTION; INFLUENZA; INFLUENZA VACCINATION; MAJOR CLINICAL STUDY; MALAISE; MALE; MYALGIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS;

ADULT; DOUBLE-BLIND METHOD; EMPLOYMENT; FEMALE; HUMANS; INFLUENZA VACCINES; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; REFERENCE VALUES;

EID: 0030035675     PISSN: 00039926     EISSN: None     Source Type: Journal    
DOI: 10.1001/archinte.156.14.1546     Document Type: Article

References (35)

1. Couch RB. Advances in influenza virus vaccine research. Ann N Y Acad Sci. 1993;685:803-812.
2. Riddiough MA, Sisk JE, Bell JC. Influenza vaccination: cost-effectiveness and public policy. JAMA. 1983;249:3189-3195.
3. Williams WW, Hickson MA, Kane MA, et al. Immunization policies and vaccine coverage among adults. Ann Intern Med. 1988;108:616-625.
4. Patriarca PA, Weber JA, Parker RA, et al. Efficacy of influenza vaccine in nursing homes. JAMA. 1985;253:1136-1169.
5. Saah AJ, Neufeld R, Rodstein M, et al. Influenza vaccine and pneumonia mortality in a nursing home population. Arch Intern Med. 1986;146:2353-2357.
6. Arden NH, Patriarca PA, Kendal AP. Experiences in the use and efficacy of inactivated influenza vaccine in nursing homes. In: Kendal AP, Patriarca PA, eds. Options for the Control of Influenza. New York, NY: Alan R Liss Inc; 1986: 155-168.
7. Gross PA, Quinnan GV, Rodstein M, et al. Association of influenza immunization with a reduction in mortality in an elderly population: a prospective study. Arch Intern Med. 1988;148:562-565.
8. Foster DA, Talsma A, Furumoto-Dawson A, et al. Influenza vaccine effectiveness in preventing hospitalization for pneumonia in the elderly. Am J Epidemiol. 1992;136:296-307.
9. Fedson DS, Wajda A, Nicol JP, et al. Clinical effectiveness of influenza vaccination in Manitoba. JAMA. 1993;270:1956-1961.
10. Nichol KL, Margolis KL, Wuorenma J, Von Sternberg T. The efficacy and cost-effectiveness of vaccination against influenza among elderly persons living in the community. N Engl J Med. 1994;331:778-784.
11. Mullooly JP, Bennett MD, Hornbrook MC, et al. Influenza vaccination programs for elderly persons. Ann Intern Med. 1994;121:947-952.
12. Edwards KM, Dupont WD, Westrich MK, Plummer WD, Pamler PS, Wright PF. A randomized controlled trial of cold-adapted and inactivated vaccines for the prevention of influenza A disease. J Infect Dis. 1994;169:68-76.
13. Centers for Disease Control and Prevention. Prevention and control of influenza. MMWR Morb Mortal Wkly Rep. 1995;44:1-22.
14. Fedson DS. Adult immunization: summary of the National Vaccine Advisory Committee report. JAMA. 1994;272:1133-1137.
15. Centers for Disease Control and Prevention. Assessing adult vaccination status at age 50. MMWR Morb Mortal Wkly Rep. 1995;44:561-563.
16. Nichol KL, Lofgren RP, Gapinski J. Influenza vaccination: knowledge, attitudes, and behavior among high-risk outpatients. Arch Intern Med. 1992;152:106-110.
17. Buchner DM, Carter WB, Inui TS. The relationship of attitude changes to compliance with influenza immunization. Med Care. 1985;23:771-779.
18. Nichol KL, Lind A, Margolis KL, et al. The effectiveness of vaccination against influenza in healthy, working adults. N Engl J Med. 1995;333:889-893.
19. Margolis KL, Poland GA, Nichol KL, et al. Frequency of adverse reactions following influenza vaccination. Am J Med. 1990;88:27-30.
20. Margolis KL, Nichol KL, Poland GA, et al. Frequency of adverse reactions to influenza vaccine in the elderly. JAMA. 1990;264:1139-1141.
21. Feinstein AR. Clinical Epidemiology: The Architecture of Clinical Research. Philadelphia, Pa: WB Saunders Co; 1985:184-186.
22. Ruben FL, Jackson GG. A new subunit influenza vaccine. J Infect Dis. 1972; 125:656-664.
23. Mostow SR, Schoenbaum SC, Dowdle WR. Studies with inactivated influenza vaccine purified by zonal centrifugation, I: adverse reactions and serological responses. Bull World Health Organ. 1969;41:525-530.
24. Parkman PD, Galasso GJ, Top FH Jr, Noble GR. Summary of clinical trials of influenza vaccines. J Infect Dis. 1976;134:100-107.
25. Mostow SR, Eickhoff TC, Chelgren GA, et al. Studies of inactivated influenza virus vaccines in hospital employees. J Infect Dis. 1977;136(suppl):533-538.
26. La Montagne JR, Noble GR, Quinnan GV, et al. Summary of clinical trials of inactivated influenza vaccine: 1978. Rev Infect Dis. 1983;5:723-736.
27. Govaert TME, Aretz K, Masurel N, et al. Adverse reactions to influenza vaccine in elderly people. BMJ. 1993;307:988-990.
28. Palache AM, Beyer WEP, Sprenger MJW, et al. Antibody response after influenza immunization with various vaccine doses. Vaccine. 1993;11:3-9.
29. Weingarten S, Staniloff H, Ault M, et al. Do hospital employees benefit from the influenza vaccine? J Gen Intern Med. 1988;3:32-37.
30. Vergrugge LM, Ascione FJ. Exploring the iceberg. Med Care. 1987;25:539-569.
31. Kroenke K, Price RK. Symptoms in the community: prevalence, classification, and psychiatric comorbidity. Arch Intern Med. 1993;153:2474-2480.
32. Smith JWG, Fletcher WB, Wherry PJ. Reactions to injected influenza vaccine. In: International Symposium on Immunity to Infections of the Respiratory System in Man and Animals, London 1974. New York, NY: S Karger AG; 1975; 28:377-388.
33. Cate TR, Couch RB, Parker D, Baxter B. Reactogenicity, immunogenicity, and antibody persistence in adults given inactivated influenza virus vaccines: 1978. Rev Infect Dis. 1983;5:737-747.
34. Al-Mazrou A, Scheitele DW, Soong T, Bjornson G. Comparison of adverse reactions to whole-virion and split-virion influenza vaccines in hospital personnel. Can Med Assoc J. 1991;145:213-218.
35. Borrud AA, Poland GA, Jacobson RM, Wollan PC. Deltoid fat pad thickness in adults: recommended needle length for intramuscular immunization. Poster abstracts of the 29th National Immunization Conference; May 1995; Los Angeles, Calif.