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Volumn 38, Issue SUPPL. 4, 2010, Pages

Influenza pathogenesis: Lessons learned from animal studies with H5N1, H1N1 Spanish and pandemic H1N1 2009 influenza

Author keywords

Animal models; Highly pathogenic influenza; Pathogenesis treatment approaches

Indexed keywords

ALPHA INTERFERON; AMANTADINE; ANTIVIRUS AGENT; CHLOROQUINE; CORTICOSTEROID; ENZYME INHIBITOR; FAVIPIRAVIR; FLUDASE; HYBRID PROTEIN; INTERFERON; INTERFERON INDUCING AGENT; OSELTAMIVIR; PERAMIVIR; PROTEIN M2; RIBAVIRIN; RIMANTADINE; SIALIDASE INHIBITOR; SMALL INTERFERING RNA; TARIBAVIRIN; TRIAMCINOLONE; UNCLASSIFIED DRUG; VIRUS SIALIDASE; ZANAMIVIR;

EID: 77950236839     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181c8b4d5     Document Type: Article
Times cited : (21)

References (129)
  • 1
    • 67649297821 scopus 로고    scopus 로고
    • Emergence and pandemic potential of swine-origin H1N1 influenza virus
    • Neumann G, Noda T, Kawaoka Y: Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature 2009; 459: 931-939
    • (2009) Nature , vol.459 , pp. 931-939
    • Neumann, G.1    Noda, T.2    Kawaoka, Y.3
  • 2
    • 12144287234 scopus 로고    scopus 로고
    • Avian influenza A (H5N1) in 10 patients in Vietnam
    • Tran TH, Nguyen TL, Nguyen TD, et al: Avian influenza A (H5N1) in 10 patients in Vietnam. N Engl J Med 2004, 350: 1179-1188
    • (2004) N Engl J Med , vol.350 , pp. 1179-1188
    • Tran, T.H.1    Nguyen, T.L.2    Nguyen, T.D.3
  • 3
    • 0032515589 scopus 로고    scopus 로고
    • Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus
    • Yuen KY, Chan PK, Peiris M, et al: Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus. Lancet 1998; 351: 467-471
    • (1998) Lancet , vol.351 , pp. 467-471
    • Yuen, K.Y.1    Chan, P.K.2    Peiris, M.3
  • 4
    • 33749511112 scopus 로고    scopus 로고
    • Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia
    • de Jong MD, Simmons CP, Thanh TT, et al: Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med 2006; 12: 1203-1207
    • (2006) Nat Med , vol.12 , pp. 1203-1207
    • De Jong, M.D.1    Simmons, C.P.2    Thanh, T.T.3
  • 5
    • 0037038866 scopus 로고    scopus 로고
    • Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: A mechanism for the unusual severity of human disease?
    • Cheung CY, Poon LL, Lau AS, et al: Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: A mechanism for the unusual severity of human disease? Lancet 2002; 360(9348): 1831-1837
    • (2002) Lancet , vol.360 , Issue.9348 , pp. 1831-1837
    • Cheung, C.Y.1    Poon, L.L.2    Lau, A.S.3
  • 6
    • 62549085229 scopus 로고    scopus 로고
    • Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus
    • U S A
    • Baskin CR, Bielefeldt-Ohmann H, Tumpey TM, et al: Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc Natl Acad Sci U S A 2009; 106: 3455-3460
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 3455-3460
    • Baskin, C.R.1    Bielefeldt-Ohmann, H.2    Tumpey, T.M.3
  • 7
    • 0033064858 scopus 로고    scopus 로고
    • A mouse model for the evaluation of pathogenesis and immunity to influenza A (H5N1) viruses isolated from humans
    • Lu X, Tumpey TM, Morken T, et al: A mouse model for the evaluation of pathogenesis and immunity to influenza A (H5N1) viruses isolated from humans. J Virol 1999; 73: 5903-5911
    • (1999) J Virol , vol.73 , pp. 5903-5911
    • Lu, X.1    Tumpey, T.M.2    Morken, T.3
  • 8
    • 0033982808 scopus 로고    scopus 로고
    • Distinct pathogenesis of hong kong-origin H5N1 viruses in mice compared to that of other highly pathogenic H5 avian influenza viruses
    • Dybing JK, Schultz-Cherry S, Swayne DE, et al: Distinct pathogenesis of hong kong-origin H5N1 viruses in mice compared to that of other highly pathogenic H5 avian influenza viruses. J Virol 2000; 74: 1443-1450
    • (2000) J Virol , vol.74 , pp. 1443-1450
    • Dybing, J.K.1    Schultz-Cherry, S.2    Swayne, D.E.3
  • 9
    • 13444292912 scopus 로고    scopus 로고
    • Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in
    • Govorkova EA, Rehg JE, Krauss S, et al: Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004. J Virol 2005; 79: 2191-2198
    • (2004) J Virol , vol.79 , pp. 2191-2198
    • Govorkova, E.A.1    Rehg, J.E.2    Krauss, S.3
  • 10
    • 24644503497 scopus 로고    scopus 로고
    • Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals
    • Maines TR, Lu XH, Erb SM, et al: Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals. J Virol 2005; 79: 11788-11800
    • (2005) J Virol , vol.79 , pp. 11788-11800
    • Maines, T.R.1    Lu, X.H.2    Erb, S.M.3
  • 11
    • 0034979498 scopus 로고    scopus 로고
    • Pathogenesis of influenza A (H5N1) virus infection in a primate model
    • Rimmelzwaan GF, Kuiken T, van Amerongen G, et al: Pathogenesis of influenza A (H5N1) virus infection in a primate model. J Virol 2001; 75: 6687-6691
    • (2001) J Virol , vol.75 , pp. 6687-6691
    • Rimmelzwaan, G.F.1    Kuiken, T.2    Van Amerongen, G.3
  • 12
    • 0036223619 scopus 로고    scopus 로고
    • Pathogenesis of avian influenza A (H5N1) viruses in ferrets
    • Zitzow LA, Rowe T, Morken T, et al: Pathogenesis of avian influenza A (H5N1) viruses in ferrets. J Virol 2002; 76: 4420-4429
    • (2002) J Virol , vol.76 , pp. 4420-4429
    • Zitzow, L.A.1    Rowe, T.2    Morken, T.3
  • 13
    • 61849117336 scopus 로고    scopus 로고
    • Pathogenesis of H5N1 influenza virus infections in mice and ferret models differs according to respiratory tract or digestive system exposure
    • Lipatov AS, Kwon YK, Pantin-Jackwood MJ, et al: Pathogenesis of H5N1 influenza virus infections in mice and ferret models differs according to respiratory tract or digestive system exposure. J Infect Dis 2009; 199: 717-725
    • (2009) J Infect Dis , vol.199 , pp. 717-725
    • Lipatov, A.S.1    Kwon, Y.K.2    Pantin-Jackwood, M.J.3
  • 14
    • 48249157351 scopus 로고    scopus 로고
    • Domestic pigs have low susceptibility to H5N1 highly pathogenic avian influenza viruses
    • Lipatov AS, Kwon YK, Sarmento LV, et al: Domestic pigs have low susceptibility to H5N1 highly pathogenic avian influenza viruses. PLoS Pathog 2008; 4: e1000102
    • (2008) PLoS Pathog , vol.4
    • Lipatov, A.S.1    Kwon, Y.K.2    Sarmento, L.V.3
  • 15
    • 33749514992 scopus 로고    scopus 로고
    • Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus
    • Kash JC, Tumpey TM, Proll SC, et al: Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature 2006; 443: 578-581
    • (2006) Nature , vol.443 , pp. 578-581
    • Kash, J.C.1    Tumpey, T.M.2    Proll, S.C.3
  • 16
    • 55549130267 scopus 로고    scopus 로고
    • Gene expression analysis of host innate immune responses during lethal H5N1 infection in ferrets
    • Cameron CM, Cameron MJ, BermejoMartin JF, et al: Gene expression analysis of host innate immune responses during lethal H5N1 infection in ferrets. J Virol 2008; 82: 11308-11317
    • (2008) J Virol , vol.82 , pp. 11308-11317
    • Cameron, C.M.1    Cameron, M.J.2    Bermejomartin, J.F.3
  • 17
    • 50849097044 scopus 로고    scopus 로고
    • H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice
    • Perrone LA, Plowden JK, Garcia-Sastre A, et al: H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathol 2008; 4: e1000115
    • (2008) PLoS Pathol , Issue.4
    • Perrone, L.A.1    Plowden, J.K.2    Garcia-Sastre, A.3
  • 18
    • 33947417049 scopus 로고    scopus 로고
    • Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice
    • Szretter KJ, Gangappa S, Lu X, et al: Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice. J Virol 2007; 81: 2736-2744
    • (2007) J Virol , vol.81 , pp. 2736-2744
    • Szretter, K.J.1    Gangappa, S.2    Lu, X.3
  • 19
    • 0034051290 scopus 로고    scopus 로고
    • Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans
    • Tumpey TM, Lu X, Morken T, et al: Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans. J Virol 2000; 74: 6105-6116
    • (2000) J Virol , vol.74 , pp. 6105-6116
    • Tumpey, T.M.1    Lu, X.2    Morken, T.3
  • 21
    • 31344482504 scopus 로고    scopus 로고
    • 1918 Influenza: The mother of all pandemics
    • Taubenberger JK, Morens DM: 1918 Influenza: The mother of all pandemics. Emerg Infect Dis 2006; 12: 15-22
    • (2006) Emerg Infect Dis , Issue.12 , pp. 15-22
    • Taubenberger, J.K.1    Morens, D.M.2
  • 22
    • 0033574005 scopus 로고    scopus 로고
    • Origin and evolution of the 1918 Spanish influenza virus hemagglutinin gene
    • U S A
    • Reid AH, Fanning TG, Hultin JV, et al: Origin and evolution of the 1918 "Spanish" influenza virus hemagglutinin gene. Proc Natl Acad Sci U S A 1999; 96: 1651-1656
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 1651-1656
    • Reid, A.H.1    Fanning, T.G.2    Hultin, J.V.3
  • 23
    • 0030987210 scopus 로고    scopus 로고
    • Initial genetic characterization of the 1918 Spanish influenza virus
    • Taubenberger JK, Reid AH, Krafft AE, et al: Initial genetic characterization of the 1918 "Spanish" influenza virus. Science 1997; 275: 1793-1796
    • (1997) Science , vol.275 , pp. 1793-1796
    • Taubenberger, J.K.1    Reid, A.H.2    Krafft, A.E.3
  • 24
    • 26444490055 scopus 로고    scopus 로고
    • Characterization of the reconstructed 1918 Spanish influenza pandemic virus
    • Tumpey TM, Basier CF, Aguilar PV, et al: Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 2005; 310: 77-80
    • (2005) Science , vol.310 , pp. 77-80
    • Tumpey, T.M.1    Basier, C.F.2    Aguilar, P.V.3
  • 25
    • 58849167264 scopus 로고    scopus 로고
    • Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets
    • U S A
    • Watanabe T, Watanabe S, Shinya K, et al: Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets. Proc Natl Acad Sci U S A 2009; 106: 588-592
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 588-592
    • Watanabe, T.1    Watanabe, S.2    Shinya, K.3
  • 26
    • 33846265834 scopus 로고    scopus 로고
    • Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus
    • Kobasa D, Jones SM, Shinya K, et al: Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature 2007; 445: 319-323
    • (2007) Nature , vol.445 , pp. 319-323
    • Kobasa, D.1    Jones, S.M.2    Shinya, K.3
  • 27
    • 66149098818 scopus 로고    scopus 로고
    • Experimental infection of pigs with the human 1918 pandemic influenza virus
    • Weingartl HM, Albrecht RA, Lager KM, et al: Experimental infection of pigs with the human 1918 pandemic influenza virus. J Virol 2009; 83: 4287-4296
    • (2009) J Virol , vol.83 , pp. 4287-4296
    • Weingartl, H.M.1    Albrecht, R.A.2    Lager, K.M.3
  • 28
    • 63149194226 scopus 로고    scopus 로고
    • Pathogenesis of 1918 pandemic and H5N1 influenza virus infections in a guinea pig model: Antiviral potential of exogenous alpha interferon to reduce virus shedding
    • Van Hoeven N, Belser JA, Szretter KJ, et al: Pathogenesis of 1918 pandemic and H5N1 influenza virus infections in a guinea pig model: antiviral potential of exogenous alpha interferon to reduce virus shedding. J Virol 2009; 83: 2851-2861
    • (2009) J Virol , vol.83 , pp. 2851-2861
    • Van Hoeven, N.1    Belser, J.A.2    Szretter, K.J.3
  • 29
    • 67650284289 scopus 로고    scopus 로고
    • Pandemic influenza. Ferrets shed light on new virus's severity and spread
    • Enserink M: Pandemic influenza. Ferrets shed light on new virus's severity and spread. Science 2009; 325: 17
    • (2009) Science , vol.325 , pp. 17
    • Enserink, M.1
  • 30
    • 16544364425 scopus 로고    scopus 로고
    • The ferret: An animal model to study influenza virus
    • Maher JA, DeStefano J: The ferret: An animal model to study influenza virus. Lab Anim (NY) 2004; 33: 50-53
    • (2004) Lab Anim (NY) , vol.33 , pp. 50-53
    • Maher, J.A.1    Destefano, J.2
  • 31
    • 33846820412 scopus 로고    scopus 로고
    • A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission
    • Tumpey TM, Maines TR, Van Hoeven N, et al: A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission. Science 2007; 315: 655-659
    • (2007) Science , vol.315 , pp. 655-659
    • Tumpey, T.M.1    Maines, T.R.2    Van Hoeven, N.3
  • 32
    • 27744598497 scopus 로고    scopus 로고
    • Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: Functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice
    • Tumpey TM, Garcia-Sastre A, Taubenberger JK, et al: Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: Functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice. J Virol 2005; 79: 14933-14944
    • (2005) J Virol , vol.79 , pp. 14933-14944
    • Tumpey, T.M.1    Garcia-Sastre, A.2    Taubenberger, J.K.3
  • 33
    • 67449110743 scopus 로고    scopus 로고
    • Emergence of a novel swine-origin influenza A (H1N1) virus in humans
    • Dawood FS, Jain S, Finelli L, et al: Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 2009; 360: 2605-2615
    • (2009) N Engl J Med , vol.360 , pp. 2605-2615
    • Dawood, F.S.1    Jain, S.2    Finelli, L.3
  • 34
    • 67749110449 scopus 로고    scopus 로고
    • Pathogenesis and transmission of swineorigin 2009 A(H1N1) influenza virus in ferrets
    • Munster VJ, de Wit E, van den Brand JM, et al: Pathogenesis and transmission of swineorigin 2009 A(H1N1) influenza virus in ferrets. Science 2009; 325: 481-483
    • (2009) Science , vol.325 , pp. 481-483
    • Munster, V.J.1    De Wit, E.2    Van Den Brand, J.M.3
  • 35
    • 69149093400 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
    • Itoh Y, Shinya K, Kiso M, et al: In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature 2009; 460: 1021-1025
    • (2009) Nature , vol.460 , pp. 1021-1025
    • Itoh, Y.1    Shinya, K.2    Kiso, M.3
  • 36
    • 67749131251 scopus 로고    scopus 로고
    • Transmission and pathogenesis of swineorigin 2009 A(H1N1) influenza viruses in ferrets and mice
    • Maines TR, Jayaraman A, Belser JA, et al: Transmission and pathogenesis of swineorigin 2009 A(H1N1) influenza viruses in ferrets and mice. Science 2009; 325: 484-487
    • (2009) Science , vol.325 , pp. 484-487
    • Maines, T.R.1    Jayaraman, A.2    Belser, J.A.3
  • 37
    • 0022157043 scopus 로고
    • The molecular basis of the specific antiinfluenza action of amantadine
    • Hay AJ, Wolstenholme AJ, Skehel JJ, et al: The molecular basis of the specific antiinfluenza action of amantadine. EMBO J 1985; 4: 3021-3024
    • (1985) EMBO J , vol.4 , pp. 3021-3024
    • Hay, A.J.1    Wolstenholme, A.J.2    Skehel, J.J.3
  • 38
    • 0019997609 scopus 로고
    • A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection
    • Dolin R, Reichman RC, Madore HP, et al: A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection. N Engl J Med 1982; 307: 580-584
    • (1982) N Engl J Med , vol.307 , pp. 580-584
    • Dolin, R.1    Reichman, R.C.2    Madore, H.P.3
  • 39
    • 0025815157 scopus 로고
    • Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine
    • Hayden FG, Sperber SJ, Belshe RB, et al: Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine. Antimicrob Agents Chemother 1991; 35: 1741-1747
    • (1991) Antimicrob Agents Chemother , vol.35 , pp. 1741-1747
    • Hayden, F.G.1    Sperber, S.J.2    Belshe, R.B.3
  • 40
    • 0024547766 scopus 로고
    • Efficacy and safety of low dosage amantadine hydrochloride as prophylaxis for influenza A
    • Reuman PD, Bernstein DI, Keefer MC, et al: Efficacy and safety of low dosage amantadine hydrochloride as prophylaxis for influenza A. Antiviral Res 1989; 11: 27-40
    • (1989) Antiviral Res , vol.11 , pp. 27-40
    • Reuman, P.D.1    Bernstein, D.I.2    Keefer, M.C.3
  • 41
    • 0020695777 scopus 로고
    • Reduction in fever and symptoms in young adults with influenza A/Brazil/78 H1N1 infection after treatment with aspirin or amantadine
    • Younkin SW, Betts RF, Roth FK, et al: Reduction in fever and symptoms in young adults with influenza A/Brazil/78 H1N1 infection after treatment with aspirin or amantadine. Antimicrob Agents Chemother 1983; 23: 577-582
    • (1983) Antimicrob Agents Chemother , vol.23 , pp. 577-582
    • Younkin, S.W.1    Betts, R.F.2    Roth, F.K.3
  • 42
    • 57749187455 scopus 로고    scopus 로고
    • Developing new antiviral agents for influenza treatment: What does the future hold?
    • Hayden F: Developing new antiviral agents for influenza treatment: what does the future hold? Clin Infect Dis 2009; 48(Suppl 1): S3-S13
    • (2009) Clin Infect Dis , vol.48 , Issue.SUPPL. 1
    • Hayden, F.1
  • 43
    • 37449007681 scopus 로고    scopus 로고
    • Amantadineresistance among H5N1 avian influenza viruses isolated in Northern China
    • He G, Qiao J, Dong C, et al: Amantadineresistance among H5N1 avian influenza viruses isolated in Northern China. Antiviral Res 2008; 77: 72-76
    • (2008) Antiviral Res , vol.77 , pp. 72-76
    • He, G.1    Qiao, J.2    Dong, C.3
  • 44
    • 0016272701 scopus 로고
    • Characterization of temperature sensitive influenza virus mutants defective in neuraminidase
    • Palese P, Tobita K, Ueda M, et al: Characterization of temperature sensitive influenza virus mutants defective in neuraminidase. Virology 1974; 61: 397-410
    • (1974) Virology , vol.61 , pp. 397-410
    • Palese, P.1    Tobita, K.2    Ueda, M.3
  • 45
    • 0017151109 scopus 로고
    • Inhibition of influenza virus replication in tissue culture by 2-deoxy-2,3-dehydro-N-trifluoroacetyl-neuraminic acid (FANA): Mechanism of action
    • Palese P, Compans RW: Inhibition of influenza virus replication in tissue culture by 2-deoxy-2,3-dehydro-N-trifluoroacetyl-neuraminic acid (FANA): Mechanism of action. J Gen Virol 1976; 33: 159-163
    • (1976) J Gen Virol , vol.33 , pp. 159-163
    • Palese, P.1    Compans, R.W.2
  • 46
    • 37549036278 scopus 로고    scopus 로고
    • Influenza virus transmission: Basic science and implications for the use of antiviral drugs during a pandemic
    • Lowen AC, Palese P: Influenza virus transmission: Basic science and implications for the use of antiviral drugs during a pandemic. Infect Disord Drug Targets 2007; 7: 318-328
    • (2007) Infect Disord Drug Targets , vol.7 , pp. 318-328
    • Lowen, A.C.1    Palese, P.2
  • 47
    • 33746634739 scopus 로고    scopus 로고
    • A comparison of the effectiveness of oseltamivir for the treatment of influenza A and influenza B: A Japanese multicenter study of the 2003-2004 and 2004-2005 influenza seasons
    • Kawai N, Ikematsu H, Iwaki N, et al: A comparison of the effectiveness of oseltamivir for the treatment of influenza A and influenza B: A Japanese multicenter study of the 2003-2004 and 2004-2005 influenza seasons. Clin Infect Dis 2006; 43: 439-444
    • (2006) Clin Infect Dis , vol.43 , pp. 439-444
    • Kawai, N.1    Ikematsu, H.2    Iwaki, N.3
  • 48
    • 34247170754 scopus 로고    scopus 로고
    • Efficacy of oseltamivir therapy in ferrets inoculated with different clades of H5N1 influenza virus
    • Govorkova EA, Ilyushina NA, Boltz DA, et al: Efficacy of oseltamivir therapy in ferrets inoculated with different clades of H5N1 influenza virus. Antimicrob Agents Chemother 2007; 51: 1414-1424
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 1414-1424
    • Govorkova, E.A.1    Ilyushina, N.A.2    Boltz, D.A.3
  • 49
    • 53249122897 scopus 로고    scopus 로고
    • Evaluation of intravenous zanamivir against experimental influenza A (H5N1) virus infection in cynomolgus macaques
    • Stittelaar KJ, Tisdale M, van Amerongen G, et al: Evaluation of intravenous zanamivir against experimental influenza A (H5N1) virus infection in cynomolgus macaques. Antiviral Res 2008; 80: 225-228
    • (2008) Antiviral Res , vol.80 , pp. 225-228
    • Stittelaar, K.J.1    Tisdale, M.2    Van Amerongen, G.3
  • 50
    • 0033929757 scopus 로고    scopus 로고
    • Metabolism of the influenza neuraminidase inhibitor prodrug oseltamivir in the rat
    • Sweeny DJ, Lynch G, Bidgood AM, et al: Metabolism of the influenza neuraminidase inhibitor prodrug oseltamivir in the rat. Drug Metab Dispos 2000; 28: 737-741
    • (2000) Drug Metab Dispos , vol.28 , pp. 737-741
    • Sweeny, D.J.1    Lynch, G.2    Bidgood, A.M.3
  • 51
    • 67349139846 scopus 로고    scopus 로고
    • Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa
    • Hurt AC, Ernest J, Deng YM, et al: Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa. Antiviral Res 2009; 83: 90-93
    • (2009) Antiviral Res , vol.83 , pp. 90-93
    • Hurt, A.C.1    Ernest, J.2    Deng, Y.M.3
  • 52
    • 40549111528 scopus 로고    scopus 로고
    • Emergence of resistance to oseltamivir among influenza A(H1N1) viruses in Europe
    • pii 8026
    • Lackenby A, Hungnes O, Dudman SG, et al: Emergence of resistance to oseltamivir among influenza A(H1N1) viruses in Europe. Euro Surveill 2008; 13: pii 8026
    • (2008) Euro Surveill , vol.13
    • Lackenby, A.1    Hungnes, O.2    Dudman, S.G.3
  • 53
    • 62149120632 scopus 로고    scopus 로고
    • Infections with oseltamivir-resistant influenza A(H1N1) virus in the United States
    • Dharan NJ, Gubareva LV, Meyer JJ, et al: Infections with oseltamivir-resistant influenza A(H1N1) virus in the United States. JAMA 2009; 301: 1034-1041
    • (2009) JAMA , vol.301 , pp. 1034-1041
    • Dharan, N.J.1    Gubareva, L.V.2    Meyer, J.J.3
  • 54
    • 68249118725 scopus 로고    scopus 로고
    • Dynamics of antiviral-resistant influenza viruses in the Netherlands, 2005-2008
    • Jonges M, van der Lubben IM, Dijkstra F, et al: Dynamics of antiviral-resistant influenza viruses in the Netherlands, 2005-2008. Antiviral Res 2009; 83: 290-297
    • (2009) Antiviral Res , vol.83 , pp. 290-297
    • Jonges, M.1    Van Der Lubben, I.M.2    Dijkstra, F.3
  • 55
    • 27144468290 scopus 로고    scopus 로고
    • Avian flu: Isolation of drug-resistant H5N1 virus
    • Le QM, Kiso M, Someya K, et al: Avian flu: isolation of drug-resistant H5N1 virus. Nature 2005; 437: 1108
    • (2005) Nature , vol.437 , pp. 1108
    • Le, Q.M.1    Kiso, M.2    Someya, K.3
  • 56
    • 70149111520 scopus 로고    scopus 로고
    • CDC: Oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infection in two summer campers receiving prophylaxisNorth Carolina, 2009
    • CDC: Oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infection in two summer campers receiving prophylaxisNorth Carolina, 2009. MMWR Morb Mortal Wkly Rep 2009; 58: 969-972
    • (2009) MMWR Morb Mortal Wkly Rep , vol.58 , pp. 969-972
  • 57
    • 72049092943 scopus 로고    scopus 로고
    • Detection of an oseltamivir-resistant pandemic influenza A/H1N1 virus in Hong Kong
    • Leung TW, Tai AL, Cheng PK, et al: Detection of an oseltamivir-resistant pandemic influenza A/H1N1 virus in Hong Kong. J Clin Virol 2009; 46: 298-299
    • (2009) J Clin Virol , vol.46 , pp. 298-299
    • Leung, T.W.1    Tai, A.L.2    Cheng, P.K.3
  • 58
    • 70349728568 scopus 로고    scopus 로고
    • Zanamivir-resistant influenza viruses with a novel neuraminidase mutation
    • Hurt AC, Holien JK, Parker M, Kelso A, Barr IG: Zanamivir-resistant influenza viruses with a novel neuraminidase mutation. J Virol 2009; 83: 10366-10373
    • (2009) J Virol , vol.83 , pp. 10366-10373
    • Hurt, A.C.1    Holien, J.K.2    Parker, M.3    Kelso, A.4    Barr, I.G.5
  • 59
    • 40849130832 scopus 로고    scopus 로고
    • Current and future antiviral therapy of severe seasonal and avian influenza
    • Beigel J, Bray M: Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res 2008; 78: 91-102
    • (2008) Antiviral Res , vol.78 , pp. 91-102
    • Beigel, J.1    Bray, M.2
  • 60
    • 33751517736 scopus 로고    scopus 로고
    • Antiviral agents active against influenza A viruses
    • De Clercq E: Antiviral agents active against influenza A viruses. Nat Rev Drug Discov 2006; 5: 1015-1025
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 1015-1025
    • De Clercq, E.1
  • 61
    • 0017686877 scopus 로고
    • Response of influenza virus-infected mice to selected doses of ribavirin administered intraperitoneally or by aerosol
    • Berendt RF, Walker JS, Dominik JW, et al: Response of influenza virus-infected mice to selected doses of ribavirin administered intraperitoneally or by aerosol. Antimicrob Agents Chemother 1977; 11: 1069-1070
    • (1977) Antimicrob Agents Chemother , vol.11 , pp. 1069-1070
    • Berendt, R.F.1    Walker, J.S.2    Dominik, J.W.3
  • 62
    • 0017811789 scopus 로고
    • Activity of amantadine, rimantadine, and ribavirin against swine influenza in mice and squirrel monkeys
    • Scott GH, Stephen EL, Berendt RF: Activity of amantadine, rimantadine, and ribavirin against swine influenza in mice and squirrel monkeys. Antimicrob Agents Chemother 1978; 13: 284-288
    • (1978) Antimicrob Agents Chemother , vol.13 , pp. 284-288
    • Scott, G.H.1    Stephen, E.L.2    Berendt, R.F.3
  • 63
    • 0018840131 scopus 로고
    • Amantadine and ribavirin aerosol treatment of influenza A and B infection in mice
    • Wilson SZ, Knight V, Wyde PR, et al: Amantadine and ribavirin aerosol treatment of influenza A and B infection in mice. Antimicrob Agents Chemother 1980; 17: 642-648
    • (1980) Antimicrob Agents Chemother , vol.17 , pp. 642-648
    • Wilson, S.Z.1    Knight, V.2    Wyde, P.R.3
  • 64
    • 41149168072 scopus 로고    scopus 로고
    • MegaRibavirin aerosol for the treatment of influenza A virus infections in mice
    • Gilbert BE, McLeay MT: MegaRibavirin aerosol for the treatment of influenza A virus infections in mice. Antiviral Res 2008; 78: 223-229
    • (2008) Antiviral Res , vol.78 , pp. 223-229
    • Gilbert, B.E.1    McLeay, M.T.2
  • 65
  • 66
    • 0018858616 scopus 로고
    • Lack of effect of oral ribavirin in naturally occurring influenza A virus (H1N1) infection
    • Smith CB, Charette RP, Fox JP, et al: Lack of effect of oral ribavirin in naturally occurring influenza A virus (H1N1) infection. J Infect Dis 1980; 141: 548-554
    • (1980) J Infect Dis , vol.141 , pp. 548-554
    • Smith, C.B.1    Charette, R.P.2    Fox, J.P.3
  • 68
    • 0028305478 scopus 로고
    • Efficacy and safety of aerosolized ribavirin in young children hospitalized with influenza: A double-blind, multicenter, placebocontrolled trial
    • Rodriguez WJ, Hall CB, Welliver R, et al: Efficacy and safety of aerosolized ribavirin in young children hospitalized with influenza: A double-blind, multicenter, placebocontrolled trial. J Pediatr 1994; 125: 129-135
    • (1994) J Pediatr , vol.125 , pp. 129-135
    • Rodriguez, W.J.1    Hall, C.B.2    Welliver, R.3
  • 69
    • 0029677207 scopus 로고    scopus 로고
    • Intravenous ribavirin by constant infusion for serious influenza and Parainfluenzavirus infection
    • Hayden FG, Sable CA, Connor JD, et al: Intravenous ribavirin by constant infusion for serious influenza and Parainfluenzavirus infection. Antivir Ther 1996; 1: 51-56
    • (1996) Antivir Ther , vol.1 , pp. 51-56
    • Hayden, F.G.1    Sable, C.A.2    Connor, J.D.3
  • 70
    • 0037228456 scopus 로고    scopus 로고
    • Activation and deactivation of a broad-spectrum antiviral drug by a single enzyme: Adenosine deaminase catalyzes two consecutive deamination reactions
    • Wu JZ, Walker H, Lau JY, et al: Activation and deactivation of a broad-spectrum antiviral drug by a single enzyme: Adenosine deaminase catalyzes two consecutive deamination reactions. Antimicrob Agents Chemother 2003; 47: 426-431
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 426-431
    • Wu, J.Z.1    Walker, H.2    Lau, J.Y.3
  • 71
    • 25144433955 scopus 로고    scopus 로고
    • In vitro and in vivo influenza virus-inhibitory effects of viramidine
    • Sidwell RW, Bailey KW, Wong MH, et al: In vitro and in vivo influenza virus-inhibitory effects of viramidine. Antiviral Res 2005; 68: 10-17
    • (2005) Antiviral Res , vol.68 , pp. 10-17
    • Sidwell, R.W.1    Bailey, K.W.2    Wong, M.H.3
  • 73
    • 47349105499 scopus 로고    scopus 로고
    • Adding interferon to lamivudine enhances the early virologic response and reversion of the precore mutation in difficult-to-treat HBV infection
    • Yuki N, Nagaoka T, Nukui K, et al: Adding interferon to lamivudine enhances the early virologic response and reversion of the precore mutation in difficult-to-treat HBV infection. J Gastroenterol 2008; 43: 457-463
    • (2008) J Gastroenterol , vol.43 , pp. 457-463
    • Yuki, N.1    Nagaoka, T.2    Nukui, K.3
  • 74
    • 44949134304 scopus 로고    scopus 로고
    • Peginterferonalpha-2a (40 kD) plus ribavirin: A review of its use in the management of chronic hepatitis C mono-infection
    • Keam SJ, Cvetkovic RS: Peginterferonalpha-2a (40 kD) plus ribavirin: a review of its use in the management of chronic hepatitis C mono-infection. Drugs 2008; 68: 1273-1317
    • (2008) Drugs , vol.68 , pp. 1273-1317
    • Keam, S.J.1    Cvetkovic, R.S.2
  • 75
    • 0026410006 scopus 로고
    • The use of interferon-alpha in virus infections
    • Finter NB, Chapman S, Dowd P, et al: The use of interferon-alpha in virus infections. Drugs 1991; 42: 749-765
    • (1991) Drugs , vol.42 , pp. 749-765
    • Finter, N.B.1    Chapman, S.2    Dowd, P.3
  • 76
    • 0020405870 scopus 로고
    • The preventive effect of human interferon-alpha on influenza infection; modification of clinical manifestations of influenza in children in a closed community
    • Isomura S, Ichikawa T, Miyazu M, et al: The preventive effect of human interferon-alpha on influenza infection; modification of clinical manifestations of influenza in children in a closed community. Biken J 1982; 25: 131-137
    • (1982) Biken J , vol.25 , pp. 131-137
    • Isomura, S.1    Ichikawa, T.2    Miyazu, M.3
  • 77
    • 0021203596 scopus 로고
    • Intranasal lymphoblastoid interferon ("Wellferon") prophylaxis against rhinovirus and influenza virus in volunteers
    • Philipotts RJ, Higgins PG, Willman JS, et al: Intranasal lymphoblastoid interferon ("Wellferon") prophylaxis against rhinovirus and influenza virus in volunteers. J Interferon Res 1984; 4: 535-541
    • (1984) J Interferon Res , vol.4 , pp. 535-541
    • Philipotts, R.J.1    Higgins, P.G.2    Willman, J.S.3
  • 78
    • 34648833226 scopus 로고    scopus 로고
    • The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses
    • Tumpey TM, Szretter KJ, Van Hoeven N, et al: The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses. J Virol 2007; 81: 10818-10821
    • (2007) J Virol , vol.81 , pp. 10818-10821
    • Tumpey, T.M.1    Szretter, K.J.2    Van Hoeven, N.3
  • 79
    • 64049119567 scopus 로고    scopus 로고
    • Intranasal administration of alpha interferon reduces seasonal influenza A virus morbidity in ferrets
    • Kugel D, Kochs G, Obojes K, et al: Intranasal administration of alpha interferon reduces seasonal influenza A virus morbidity in ferrets. J Virol 2009; 83: 3843-3851
    • (2009) J Virol , vol.83 , pp. 3843-3851
    • Kugel, D.1    Kochs, G.2    Obojes, K.3
  • 80
    • 0035925552 scopus 로고    scopus 로고
    • Immunoprophylactic strategies against respiratory influenza virus infection
    • Saravolac EG, Sabuda D, Crist C, et al: Immunoprophylactic strategies against respiratory influenza virus infection. Vaccine 2001; 19: 2227-2232
    • (2001) Vaccine , vol.19 , pp. 2227-2232
    • Saravolac, E.G.1    Sabuda, D.2    Crist, C.3
  • 82
    • 35848929321 scopus 로고    scopus 로고
    • The threat of avian influenza A (H5N1). Part III: Antiviral therapy
    • Cinatl J Jr, Michaelis M, Doerr HW: The threat of avian influenza A (H5N1). Part III: Antiviral therapy. Med Microbiol Immunol 2007; 196: 203-212
    • (2007) Med Microbiol Immunol , vol.196 , pp. 203-212
    • Cinatl Jr., J.1    Michaelis, M.2    Doerr, H.W.3
  • 83
    • 26244454781 scopus 로고    scopus 로고
    • The cotton rat provides a useful smallanimal model for the study of influenza virus pathogenesis
    • Ottolini MG, Blanco JC, Eichelberger MC, et al: The cotton rat provides a useful smallanimal model for the study of influenza virus pathogenesis. J Gen Virol 2005; 86: 2823-2830
    • (2005) J Gen Virol , vol.86 , pp. 2823-2830
    • Ottolini, M.G.1    Blanco, J.C.2    Eichelberger, M.C.3
  • 84
    • 34547619982 scopus 로고    scopus 로고
    • Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection
    • U S A
    • Salomon R, Hoffmann E, Webster RG: Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection. Proc Natl Acad Sci U S A 2007; 104: 12479-12481
    • (2007) Proc Natl Acad Sci , vol.104 , pp. 12479-12481
    • Salomon, R.1    Hoffmann, E.2    Webster, R.G.3
  • 85
    • 0344089298 scopus 로고    scopus 로고
    • Changes in function of iron-loaded alveolar macrophages after in vivo administration of desferrioxamine and/or chloroquine
    • Legssyer R, Josse C, Piette J, et al: Changes in function of iron-loaded alveolar macrophages after in vivo administration of desferrioxamine and/or chloroquine. J Inorg Biochem 2003; 94: 36-42
    • (2003) J Inorg Biochem , vol.94 , pp. 36-42
    • Legssyer, R.1    Josse, C.2    Piette, J.3
  • 86
    • 0019788761 scopus 로고
    • Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances
    • Ohkuma S, Poole B: Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances. J Cell Biol 1981; 90: 656-664
    • (1981) J Cell Biol , vol.90 , pp. 656-664
    • Ohkuma, S.1    Poole, B.2
  • 87
    • 0242355070 scopus 로고    scopus 로고
    • Effects of chloroquine on viral infections: An old drug against today's diseases?
    • Savarino A, Boelaert JR, Cassone A, et al: Effects of chloroquine on viral infections: an old drug against today's diseases?. Lancet Infect Dis 2003; 3: 722-727
    • (2003) Lancet Infect Dis , vol.3 , pp. 722-727
    • Savarino, A.1    Boelaert, J.R.2    Cassone, A.3
  • 88
    • 33745328312 scopus 로고    scopus 로고
    • In vitro inhibition of human influenza A virus replication by chloroquine
    • Ooi EE, Chew JS, Loh JP, et al: In vitro inhibition of human influenza A virus replication by chloroquine. Virol J 2006; 3: 39
    • (2006) Virol J , vol.3 , pp. 39
    • Ooi, E.E.1    Chew, J.S.2    Loh, J.P.3
  • 89
    • 66449100701 scopus 로고    scopus 로고
    • Chloroquine is effective against influenza A virus in vitro but not in vivo
    • Vigerust DJ, McCullers JA: Chloroquine is effective against influenza A virus in vitro but not in vivo. Influenza Other Respi Viruses 2007; 1: 189-192
    • (2007) Influenza Other Respi Viruses , vol.1 , pp. 189-192
    • Vigerust, D.J.1    McCullers, J.A.2
  • 90
    • 33845405207 scopus 로고    scopus 로고
    • Inhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cells
    • Jones JC, Turpin EA, Bultmann H, et al: Inhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cells. J Virol 2006; 80: 11960-11967
    • (2006) J Virol , vol.80 , pp. 11960-11967
    • Jones, J.C.1    Turpin, E.A.2    Bultmann, H.3
  • 91
    • 27144511726 scopus 로고    scopus 로고
    • Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins
    • Leikina E, Delanoe-Ayari H, Melikov K, et al: Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins. Nat Immunol 2005; 6: 995-1001
    • (2005) Nat Immunol , vol.6 , pp. 995-1001
    • Leikina, E.1    Delanoe-Ayari, H.2    Melikov, K.3
  • 92
    • 0035997947 scopus 로고    scopus 로고
    • Polymeric inhibitor of influenza virus attachment protects mice from experimental influenza infection
    • Gambaryan AS, Tuzikov AB, Chinarev AA, et al: Polymeric inhibitor of influenza virus attachment protects mice from experimental influenza infection. Antiviral Res 2002; 55: 201-205
    • (2002) Antiviral Res , vol.55 , pp. 201-205
    • Gambaryan, A.S.1    Tuzikov, A.B.2    Chinarev, A.A.3
  • 93
    • 38449093101 scopus 로고    scopus 로고
    • DAS181, a novel sialidase fusion protein, protects mice from lethal avian influenza H5N1 virus infection
    • Belser JA, Lu X, Szretter KJ, et al: DAS181, a novel sialidase fusion protein, protects mice from lethal avian influenza H5N1 virus infection. J Infect Dis 2007; 196: 1493-1499
    • (2007) J Infect Dis , vol.196 , pp. 1493-1499
    • Belser, J.A.1    Lu, X.2    Szretter, K.J.3
  • 94
    • 33645765519 scopus 로고    scopus 로고
    • Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection
    • Malakhov MP, Aschenbrenner LM, Smee DF, et al: Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection. Antimicrob Agents Chemother 2006; 50: 1470-1479
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 1470-1479
    • Malakhov, M.P.1    Aschenbrenner, L.M.2    Smee, D.F.3
  • 95
    • 70349122523 scopus 로고    scopus 로고
    • DAS181 Inhibits H5N1 Influenza virus Infection of Human Lung Tissues
    • Chan RW, Chan MC, Wong AC, et al: DAS181 Inhibits H5N1 Influenza virus Infection of Human Lung Tissues. Antimicrob Agents Chemother 2009; 53: 3935-3941
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 3935-3941
    • Chan, R.W.1    Chan, M.C.2    Wong, A.C.3
  • 96
    • 0023106232 scopus 로고
    • High protection of animals lethally infected with influenza virus by aprotinin-rimantadine combination
    • Zhirnov OP: High protection of animals lethally infected with influenza virus by aprotinin-rimantadine combination. J Med Virol 1987; 21: 161-167
    • (1987) J Med Virol , vol.21 , pp. 161-167
    • Zhirnov, O.P.1
  • 97
    • 0029686394 scopus 로고    scopus 로고
    • Clinical effectiveness of aprotinin aerosol in influenza and parainfluenza
    • Zhirnov OP, Kirzhner LS, Ovcharenko AV, et al: [Clinical effectiveness of aprotinin aerosol in influenza and parainfluenza]. Vestn Ross Akad Med Nauk 1996; 5: 26-31
    • (1996) Vestn Ross Akad Med Nauk , vol.5 , pp. 26-31
    • Zhirnov, O.P.1    Kirzhner, L.S.2    Ovcharenko, A.V.3
  • 98
    • 29044434743 scopus 로고    scopus 로고
    • Antiinfluenza virus activity of peramivir in mice with single intramuscular injection
    • Bantia S, Arnold CS, Parker CD, et al: Antiinfluenza virus activity of peramivir in mice with single intramuscular injection. Antiviral Res 2006; 69: 39-45
    • (2006) Antiviral Res , vol.69 , pp. 39-45
    • Bantia, S.1    Arnold, C.S.2    Parker, C.D.3
  • 99
    • 53249125778 scopus 로고    scopus 로고
    • Intramuscularly administered neuraminidase inhibitor peramivir is effective against lethal H5N1 influenza virus in mice
    • Boltz DA, Ilyushina NA, Arnold CS, et al: Intramuscularly administered neuraminidase inhibitor peramivir is effective against lethal H5N1 influenza virus in mice. Antiviral Res 2008; 80: 150-157
    • (2008) Antiviral Res , vol.80 , pp. 150-157
    • Boltz, D.A.1    Ilyushina, N.A.2    Arnold, C.S.3
  • 100
    • 41649105849 scopus 로고    scopus 로고
    • Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1)
    • Yun NE, Linde NS, Zacks MA, et al: Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1). Virology 2008; 374: 198-209
    • (2008) Virology , vol.374 , pp. 198-209
    • Yun, N.E.1    Linde, N.S.2    Zacks, M.A.3
  • 101
    • 30444444254 scopus 로고    scopus 로고
    • Efficacy and tolerability of the oral neuraminidase inhibitor peramivir in experimental human influenza: Randomized, controlled trials for prophylaxis and treatment
    • Barroso L, Treanor J, Gubareva L, et al: Efficacy and tolerability of the oral neuraminidase inhibitor peramivir in experimental human influenza: randomized, controlled trials for prophylaxis and treatment. Antivir Ther 2005; 10: 901-910
    • (2005) Antivir Ther , vol.10 , pp. 901-910
    • Barroso, L.1    Treanor, J.2    Gubareva, L.3
  • 102
    • 0019394947 scopus 로고
    • A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription
    • Plotch SJ, Bouloy M, Ulmanen I, et al: A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription. Cell 1981; 23: 847-858
    • (1981) Cell , vol.23 , pp. 847-858
    • Plotch, S.J.1    Bouloy, M.2    Ulmanen, I.3
  • 103
    • 0028846207 scopus 로고
    • Inhibition of influenza virus transcription by 2′deoxy-2′- fluoroguanosine
    • Tisdale M, Ellis M, Klumpp K, et al: Inhibition of influenza virus transcription by 2′deoxy-2′-fluoroguanosine. Antimicrob Agents Chemother 1995; 39: 2454-2458
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 2454-2458
    • Tisdale, M.1    Ellis, M.2    Klumpp, K.3
  • 104
    • 0027400040 scopus 로고
    • Purine 2′-deoxy-2′-fluororibosides as antiinfluenza virus agents
    • Tuttle JV, Tisdale M, Krenitsky TA: Purine 2′-deoxy-2′- fluororibosides as antiinfluenza virus agents. J Med Chem 1993; 36: 119-125
    • (1993) J Med Chem , vol.36 , pp. 119-125
    • Tuttle, J.V.1    Tisdale, M.2    Krenitsky, T.A.3
  • 106
    • 33847688459 scopus 로고    scopus 로고
    • Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice
    • Sidwell RW, Barnard DL, Day CW, et al: Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice. Antimicrob Agents Chemother 2007; 51: 845-851
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 845-851
    • Sidwell, R.W.1    Barnard, D.L.2    Day, C.W.3
  • 107
    • 64749093901 scopus 로고    scopus 로고
    • T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections
    • Furuta Y, Takahashi K, Shiraki K, et al: T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections. Antiviral Res 2009; 82: 95-102
    • (2009) Antiviral Res , vol.82 , pp. 95-102
    • Furuta, Y.1    Takahashi, K.2    Shiraki, K.3
  • 108
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W, et al: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001; 411: 494-498
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3
  • 109
    • 0037418322 scopus 로고    scopus 로고
    • RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription
    • USA
    • Ge Q, McManus MT, Nguyen T, et al: RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc Natl Acad Sci USA 2003; 100: 2718-2723
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 2718-2723
    • Ge, Q.1    McManus, M.T.2    Nguyen, T.3
  • 110
    • 2942530436 scopus 로고    scopus 로고
    • Inhibition of influenza virus production in virus-infected mice by RNA interference
    • U S A
    • Ge Q, Filip L, Bai A, et al: Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc Natl Acad Sci U S A 2004; 101: 8676-8681
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 8676-8681
    • Ge, Q.1    Filip, L.2    Bai, A.3
  • 111
    • 2942620143 scopus 로고    scopus 로고
    • Protection against lethal influenza virus challenge by RNA interference in vivo
    • U S A
    • Tompkins SM, Lo CY, Tumpey TM, et al: Protection against lethal influenza virus challenge by RNA interference in vivo. Proc Natl Acad Sci U S A 2004; 101: 8682-8686
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 8682-8686
    • Tompkins, S.M.1    Lo, C.Y.2    Tumpey, T.M.3
  • 112
    • 24744466699 scopus 로고    scopus 로고
    • Using siRNA in prophylactic and therapeutic regimens against SARS Coronavirus in Rhesus macaque
    • Li BJ, Tang Q, Cheng D, et al: Using siRNA in prophylactic and therapeutic regimens against SARS Coronavirus in Rhesus macaque. Nat Med 2005; 11: 944-951
    • (2005) Nat Med , vol.11 , pp. 944-951
    • Li, B.J.1    Tang, Q.2    Cheng, D.3
  • 113
    • 0033829661 scopus 로고    scopus 로고
    • Antibodies for the prevention and treatment of viral diseases
    • Sawyer LA: Antibodies for the prevention and treatment of viral diseases. Antiviral Res 2000; 47: 57-77
    • (2000) Antiviral Res , vol.47 , pp. 57-77
    • Sawyer, L.A.1
  • 114
    • 33750721332 scopus 로고    scopus 로고
    • Meta-analysis: Convalescent blood products for Spanish influenza pneumonia: A future H5N1 treatment?
    • Luke TC, Kilbane EM, Jackson JL, et al: Meta-analysis: Convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment?. Ann Intern Med 2006; 145: 599-609
    • (2006) Ann Intern Med , vol.145 , pp. 599-609
    • Luke, T.C.1    Kilbane, E.M.2    Jackson, J.L.3
  • 115
    • 34948813121 scopus 로고    scopus 로고
    • Treatment with convalescent plasma for influenza A (H5N1) infection
    • Zhou B, Zhong N, Guan Y: Treatment with convalescent plasma for influenza A (H5N1) infection. N Engl J Med 2007; 357: 1450-1451
    • (2007) N Engl J Med , vol.357 , pp. 1450-1451
    • Zhou, B.1    Zhong, N.2    Guan, Y.3
  • 116
    • 42649132198 scopus 로고    scopus 로고
    • Probable limited person-to-person transmission of highly pathogenic avian influenza A (H5N1) virus in China
    • Wang H, Feng Z, Shu Y, et al: Probable limited person-to-person transmission of highly pathogenic avian influenza A (H5N1) virus in China. Lancet 2008; 371: 1427-1434
    • (2008) Lancet , vol.371 , pp. 1427-1434
    • Wang, H.1    Feng, Z.2    Shu, Y.3
  • 117
    • 0028158626 scopus 로고
    • Protection against the mouse-adapted A/FM/1/47 strain of influenza A virus in mice by a monoclonal antibody with crossneutralizing activity among H1 and H2 strains
    • Okuno Y, Matsumoto K, Isegawa Y, et al: Protection against the mouse-adapted A/FM/1/47 strain of influenza A virus in mice by a monoclonal antibody with crossneutralizing activity among H1 and H2 strains. J Virol 1994; 68: 517-520
    • (1994) J Virol , vol.68 , pp. 517-520
    • Okuno, Y.1    Matsumoto, K.2    Isegawa, Y.3
  • 118
    • 0028965256 scopus 로고
    • Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice
    • Palladino G, Mozdzanowska K, Washko G, et al: Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice. J Virol 1995; 69: 2075-2081
    • (1995) J Virol , vol.69 , pp. 2075-2081
    • Palladino, G.1    Mozdzanowska, K.2    Washko, G.3
  • 119
    • 0037770360 scopus 로고    scopus 로고
    • Virus-neutralizing activity mediated by the Fab fragment of a hemagglutinin-specific antibody is sufficient for the resolution of influenza virus infection in SCID mice
    • Mozdzanowska K, Feng J, Gerhard W: Virus-neutralizing activity mediated by the Fab fragment of a hemagglutinin-specific antibody is sufficient for the resolution of influenza virus infection in SCID mice. J Virol 2003; 77: 8322-8328
    • (2003) J Virol , vol.77 , pp. 8322-8328
    • Mozdzanowska, K.1    Feng, J.2    Gerhard, W.3
  • 120
    • 34249669303 scopus 로고    scopus 로고
    • Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza
    • Simmons CP, Bernasconi NL, Suguitan AL, et al: Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza. PLoS Med 2007; 4: e178
    • (2007) PLoS Med , vol.4
    • Simmons, C.P.1    Bernasconi, N.L.2    Suguitan, A.L.3
  • 121
    • 33750422851 scopus 로고    scopus 로고
    • Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice
    • Hanson BJ, Boon AC, Lim AP, et al: Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice. Respir Res 2006; 7: 126
    • (2006) Respir Res , vol.7 , pp. 126
    • Hanson, B.J.1    Boon, A.C.2    Lim, A.P.3
  • 122
    • 65449121533 scopus 로고    scopus 로고
    • Seasonal influenza vaccines: Evolutions and future trends
    • Monto AS, Ohmit SE: Seasonal influenza vaccines: evolutions and future trends. Expert Rev Vacdnes 2009; 8: 383-389
    • (2009) Expert Rev Vacdnes , vol.8 , pp. 383-389
    • Monto, A.S.1    Ohmit, S.E.2
  • 123
    • 67349145958 scopus 로고    scopus 로고
    • Adjuvanted seasonal influenza vaccines and perpetual viral metamorphosis: The importance of cross-protection
    • Ansaldi F, Canepa P, Parodi V, et al: Adjuvanted seasonal influenza vaccines and perpetual viral metamorphosis: the importance of cross-protection. Vaccine 2009; 27: 3345-3348
    • (2009) Vaccine , vol.27 , pp. 3345-3348
    • Ansaldi, F.1    Canepa, P.2    Parodi, V.3
  • 124
    • 67449102487 scopus 로고    scopus 로고
    • Trivalent MDCK cell culture-derived influenza vaccine Optaflu (Novartis Vaccines)
    • Doroshenko A, Halperin SA: Trivalent MDCK cell culture-derived influenza vaccine Optaflu (Novartis Vaccines). Expert Rev Vaccines 2009; 8: 679-688
    • (2009) Expert Rev Vaccines , vol.8 , pp. 679-688
    • Doroshenko, A.1    Halperin, S.A.2
  • 125
    • 70350567189 scopus 로고    scopus 로고
    • Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses
    • Price GE, Soboleski MR, Lo CY, et al: Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses. Vaccine 2009; 27: 6512-6521
    • (2009) Vaccine , vol.27 , pp. 6512-6521
    • Price, G.E.1    Soboleski, M.R.2    Lo, C.Y.3
  • 126
    • 67349094613 scopus 로고    scopus 로고
    • Evaluation of conserved and variable influenza antigens for immunization against different isolates of H5N1 viruses
    • Patel A, Tran K, Gray M, et al: Evaluation of conserved and variable influenza antigens for immunization against different isolates of H5N1 viruses. Vaccine 2009; 27: 3083-3089
    • (2009) Vaccine , vol.27 , pp. 3083-3089
    • Patel, A.1    Tran, K.2    Gray, M.3
  • 127
  • 128
    • 0038486953 scopus 로고    scopus 로고
    • Pathology of human influenza A (H5N1) virus infection in cynomolgus macaques (Macaca fascicularis)
    • Kuiken T, Rimmelzwaan GF, Van Amerongen G, et al: Pathology of human influenza A (H5N1) virus infection in cynomolgus macaques (Macaca fascicularis). Vet Pathol 2003; 40304-40310
    • (2003) Vet Pathol , pp. 40304-40310
    • Kuiken, T.1    Rimmelzwaan, G.F.2    Van Amerongen, G.3
  • 129
    • 23244441124 scopus 로고    scopus 로고
    • Studies of H5N1 influenza virus infection of pigs by using viruses isolated in Vietnam and Thailand in 2004
    • Choi YK, Nguyen TD, Ozaki H, et al: Studies of H5N1 influenza virus infection of pigs by using viruses isolated in Vietnam and Thailand in 2004. J Virol 2005; 79: 10821-10825
    • (2005) J Virol , vol.79 , pp. 10821-10825
    • Choi, Y.K.1    Nguyen, T.D.2    Ozaki, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.