메뉴 건너뛰기




Volumn 4 MAY, Issue , 2014, Pages

The role of the tumor stroma in ovarian cancer

Author keywords

Metastasis; Ovarian carcinoma; Prognosis; Stromal myofibroblasts; Tumor progression

Indexed keywords

ANGIOGENIC FACTOR; CATHEPSIN B; CATHEPSIN D; CELL SURFACE RECEPTOR; COLLAGEN TYPE 1; CYTOKINE; DOXORUBICIN; ETOPOSIDE; FIBROBLAST GROWTH FACTOR 2; GALECTIN 1; GELATINASE A; GELATINASE B; GROWTH FACTOR; HERMES ANTIGEN; HYALURONIC ACID; MATRIX METALLOPROTEINASE; MESSENGER RNA; PROSTAGLANDIN E SYNTHASE 1; PROTEIN P53; PROTEINASE; RIBONUCLEASE; SURVIVIN; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSCRIPTION FACTOR; UROKINASE; VASCULOTROPIN;

EID: 84904617133     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2014.00104     Document Type: Review
Times cited : (44)

References (135)
  • 1
    • 84876721085 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells
    • doi: 10.1002/jcp.24347
    • Polanska UM, Orimo A. Carcinoma-associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells. J Cell Physiol (2013) 228:1651-7. doi: 10.1002/jcp.24347
    • (2013) J Cell Physiol , vol.228 , pp. 1651-1657
    • Polanska, U.M.1    Orimo, A.2
  • 2
    • 84877065511 scopus 로고    scopus 로고
    • Fibroblasts as architects of cancer pathogenesis
    • doi:10.1016/j.bbadis.2012.10.013
    • Marsh T, Pietras K, McAllister SS. Fibroblasts as architects of cancer pathogenesis. Biochim Biophys Acta (2013) 1832:1070-8. doi:10.1016/j.bbadis.2012.10.013
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 1070-1078
    • Marsh, T.1    Pietras, K.2    McAllister, S.S.3
  • 3
    • 84869225491 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue
    • doi:10.1158/1541-7786.MCR-12-0307
    • Karagiannis GS, Poutahidis T, Erdman SE, Kirsch R, Riddell RH, Diamandis EP. Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue. Mol Cancer Res (2012) 10:1403-18. doi:10.1158/1541-7786.MCR-12-0307
    • (2012) Mol Cancer Res , vol.10 , pp. 1403-1418
    • Karagiannis, G.S.1    Poutahidis, T.2    Erdman, S.E.3    Kirsch, R.4    Riddell, R.H.5    Diamandis, E.P.6
  • 4
    • 84882619034 scopus 로고    scopus 로고
    • Targeting the tumor microenvironment: from understanding pathways to effective clinical trials
    • doi:10.1158/0008-5472.CAN-13-0661
    • Fang H, Declerck YA. Targeting the tumor microenvironment: from understanding pathways to effective clinical trials. Cancer Res (2013) 73:4965-77. doi:10.1158/0008-5472.CAN-13-0661
    • (2013) Cancer Res , vol.73 , pp. 4965-4977
    • Fang, H.1    Declerck, Y.A.2
  • 5
    • 84855792427 scopus 로고    scopus 로고
    • Cancer statistics, 2012
    • doi:10.3322/caac.21149
    • Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin (2012) 62:10-29. doi:10.3322/caac.21149
    • (2012) CA Cancer J Clin , vol.62 , pp. 10-29
    • Siegel, R.1    Naishadham, D.2    Jemal, A.3
  • 6
    • 84860336909 scopus 로고    scopus 로고
    • Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features
    • doi:10.1007/s00428-012-1203-5
    • Prat J. Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features. Virchows Arch (2012) 460:237-49. doi:10.1007/s00428-012-1203-5
    • (2012) Virchows Arch , vol.460 , pp. 237-249
    • Prat, J.1
  • 7
    • 70349847555 scopus 로고    scopus 로고
    • Ovarian cancer
    • doi:10. 1016/S0140-6736(09)61338-6
    • Hennessy BT, Coleman RL, Markman M. Ovarian cancer. Lancet (2009) 374:1371-82. doi:10.1016/S0140-6736(09)61338-6
    • (2009) Lancet , vol.374 , pp. 1371-1382
    • Hennessy, B.T.1    Coleman, R.L.2    Markman, M.3
  • 8
    • 74249107190 scopus 로고    scopus 로고
    • Stromal compartment as a survival prognostic factor in advanced ovarian carcinoma
    • doi:10.1111/IGC.0b013e3181bda1cb
    • Labiche A, Heutte N, Herlin P, Chasle J, Gauduchon P, Elie N. Stromal compartment as a survival prognostic factor in advanced ovarian carcinoma. Int J Gynecol Cancer (2010) 20:28-33. doi:10.1111/IGC.0b013e3181bda1cb
    • (2010) Int J Gynecol Cancer , vol.20 , pp. 28-33
    • Labiche, A.1    Heutte, N.2    Herlin, P.3    Chasle, J.4    Gauduchon, P.5    Elie, N.6
  • 9
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • doi:10.1038/nrc745
    • Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer (2002) 2:161-74. doi:10.1038/nrc745
    • (2002) Nat Rev Cancer , vol.2 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 10
    • 19344366798 scopus 로고    scopus 로고
    • Gelatinase-mediated migration and invasion of cancer cells
    • doi:10.1016/j.bbcan.2005.03.001
    • Bjorklund M, Koivunen E. Gelatinase-mediated migration and invasion of cancer cells. Biochim Biophys Acta (2005) 1755:37-69. doi:10.1016/j.bbcan.2005.03.001
    • (2005) Biochim Biophys Acta , vol.1755 , pp. 37-69
    • Bjorklund, M.1    Koivunen, E.2
  • 11
    • 80054997801 scopus 로고    scopus 로고
    • New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: outside-in signaling and relationship to tumor progression
    • doi:10.1016/j.bbcan.2011.10.001
    • Bauvois B. New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: outside-in signaling and relationship to tumor progression. Biochim Biophys Acta (2012) 1825:29-36. doi:10.1016/j.bbcan.2011.10.001
    • (2012) Biochim Biophys Acta , vol.1825 , pp. 29-36
    • Bauvois, B.1
  • 12
    • 0032955336 scopus 로고    scopus 로고
    • MMP-2 release and activation in ovarian carcinoma: the role of fibroblasts
    • doi:10.1038/sj.bjc.6690357
    • Boyd RS, Balkwill FR. MMP-2 release and activation in ovarian carcinoma: the role of fibroblasts. Br J Cancer (1999) 80:315-21. doi:10.1038/sj.bjc.6690357
    • (1999) Br J Cancer , vol.80 , pp. 315-321
    • Boyd, R.S.1    Balkwill, F.R.2
  • 13
    • 0037036679 scopus 로고    scopus 로고
    • Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice
    • doi:10.1093/jnci/94.15.1134
    • Huang S, Van Arsdall M, Tedjarati S, McCarty M, Wu W, Langley R, et al. Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice. J Natl Cancer Inst (2002) 94:1134-42. doi:10.1093/jnci/94.15.1134
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1134-1142
    • Huang, S.1    Van Arsdall, M.2    Tedjarati, S.3    McCarty, M.4    Wu, W.5    Langley, R.6
  • 14
    • 9944223360 scopus 로고    scopus 로고
    • Correlation of tumor- and stromal-derived MT1-MMP expression with progression of human ovarian tumors in SCID mice
    • doi:10.1016/j.ygyno.2004.08.032
    • Drew AF, Blick TJ, Lafleur MA, Tim EL, Robbie MJ, Rice GE, et al. Correlation of tumor- and stromal-derived MT1-MMP expression with progression of human ovarian tumors in SCID mice. Gynecol Oncol (2004) 95:437-48. doi:10.1016/j.ygyno.2004.08.032
    • (2004) Gynecol Oncol , vol.95 , pp. 437-448
    • Drew, A.F.1    Blick, T.J.2    Lafleur, M.A.3    Tim, E.L.4    Robbie, M.J.5    Rice, G.E.6
  • 16
    • 0028178968 scopus 로고
    • Expression and activity of MMPS and their regulators in ovarian cancer
    • doi:10.1002/ijc.2910580110
    • Naylor MS, Stamp GW, Davies BD, Balkwill FR. Expression and activity of MMPS and their regulators in ovarian cancer. Int J Cancer (1994) 58:50-6. doi:10.1002/ijc.2910580110
    • (1994) Int J Cancer , vol.58 , pp. 50-56
    • Naylor, M.S.1    Stamp, G.W.2    Davies, B.D.3    Balkwill, F.R.4
  • 17
    • 0030030957 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression and synthetic matrix metalloproteinase-2 inhibitor binding in ovarian carcinomas and tumor cell lines
    • Afzal S, Lalani N, Foulkes WD, Boyce B, Tickle S, Cardillo MR, et al. Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression and synthetic matrix metalloproteinase-2 inhibitor binding in ovarian carcinomas and tumor cell lines. Lab Invest (1996) 74:406-21.
    • (1996) Lab Invest , vol.74 , pp. 406-421
    • Afzal, S.1    Lalani, N.2    Foulkes, W.D.3    Boyce, B.4    Tickle, S.5    Cardillo, M.R.6
  • 18
    • 0031909775 scopus 로고    scopus 로고
    • MT1-MMP and MMP-2 mRNA expression in human ovarian tumors: possible implications for the role of desmoplastic fibroblasts
    • doi:10. 1016/S0046-8177(98)90226-X
    • Afzal S, Lalani EN, Poulsom R, Stubbs A, Rowlinson G, Sato H, et al. MT1-MMP and MMP-2 mRNA expression in human ovarian tumors: possible implications for the role of desmoplastic fibroblasts. Hum Pathol (1998) 29:155-65. doi:10.1016/S0046-8177(98)90226-X
    • (1998) Hum Pathol , vol.29 , pp. 155-165
    • Afzal, S.1    Lalani, E.N.2    Poulsom, R.3    Stubbs, A.4    Rowlinson, G.5    Sato, H.6
  • 19
    • 0033762457 scopus 로고    scopus 로고
    • High levels of MMP-2, MMP-9, MT1-MMP and TIMP-2 mRNA correlate with poor survival in ovarian carcinoma
    • doi:10.1023/A:1006723011835
    • Davidson B, Goldberg I, Gotlieb WH, Kopolovic J, Ben-Baruch G, Nesland JM, et al. High levels of MMP-2, MMP-9, MT1-MMP and TIMP-2 mRNA correlate with poor survival in ovarian carcinoma. Clin Exp Metastasis (1999) 17:799-808. doi:10.1023/A:1006723011835
    • (1999) Clin Exp Metastasis , vol.17 , pp. 799-808
    • Davidson, B.1    Goldberg, I.2    Gotlieb, W.H.3    Kopolovic, J.4    Ben-Baruch, G.5    Nesland, J.M.6
  • 20
    • 0032871733 scopus 로고    scopus 로고
    • Gelatinase A-immunoreactive protein in ovarian lesions - prognostic value in epithelial ovarian cancer
    • doi:10.1006/gyno.1999.5533
    • Westerlund A, Apaja-Sarkkinen M, Höyhtyä M, Puistola U, Turpeenniemi-Hujanen T. Gelatinase A-immunoreactive protein in ovarian lesions - prognostic value in epithelial ovarian cancer. Gynecol Oncol (1999) 75:91-8. doi:10.1006/gyno.1999.5533
    • (1999) Gynecol Oncol , vol.75 , pp. 91-98
    • Westerlund, A.1    Apaja-Sarkkinen, M.2    Höyhtyä, M.3    Puistola, U.4    Turpeenniemi-Hujanen, T.5
  • 21
    • 0034043943 scopus 로고    scopus 로고
    • Differential expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 protein and mRNA in epithelial ovarian tumors
    • doi:10.1006/gyno.2000.5806
    • Huang LW, Garrett AP, Bell DA, Welch WR, Berkowitz RS, Mok SC. Differential expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 protein and mRNA in epithelial ovarian tumors. Gynecol Oncol (2000) 77:369-76. doi:10.1006/gyno.2000.5806
    • (2000) Gynecol Oncol , vol.77 , pp. 369-376
    • Huang, L.W.1    Garrett, A.P.2    Bell, D.A.3    Welch, W.R.4    Berkowitz, R.S.5    Mok, S.C.6
  • 22
    • 0035430150 scopus 로고    scopus 로고
    • Invasive properties of serous human epithelial ovarian tumors are related to Ets-1, MMP-1 and MMP-9 expression
    • doi:10.3892/ijmm.8.2.149
    • Behrens P, Rothe M, Florin A, Wellmann A, Wernert N. Invasive properties of serous human epithelial ovarian tumors are related to Ets-1, MMP-1 and MMP-9 expression. Int J Mol Med (2001) 8:149-54. doi:10.3892/ijmm.8.2.149
    • (2001) Int J Mol Med , vol.8 , pp. 149-154
    • Behrens, P.1    Rothe, M.2    Florin, A.3    Wellmann, A.4    Wernert, N.5
  • 23
    • 0034779239 scopus 로고    scopus 로고
    • Ovarian carcinoma cells in serous effusions show altered MMP-2 and TIMP-2 mRNA levels
    • doi:10. 1016/S0959-8049(01)00235-0
    • Davidson B, Reich R, Berner A, Givant-Horwitz V, Goldberg I, Risberg B, et al. Ovarian carcinoma cells in serous effusions show altered MMP-2 and TIMP-2 mRNA levels. Eur J Cancer (2001) 37:2040-9. doi:10.1016/S0959-8049(01)00235-0
    • (2001) Eur J Cancer , vol.37 , pp. 2040-2049
    • Davidson, B.1    Reich, R.2    Berner, A.3    Givant-Horwitz, V.4    Goldberg, I.5    Risberg, B.6
  • 24
    • 0035124046 scopus 로고    scopus 로고
    • Clarification of the active gelatinolytic sites in human ovarian neoplasms using in situ zymography
    • doi:10.1053/hupa.2001.21558
    • Furuya M, Ishikura H, Nemori R, Shibata M, Fujimoto S, Yoshiki T. Clarification of the active gelatinolytic sites in human ovarian neoplasms using in situ zymography. Hum Pathol (2001) 32:163-8. doi:10.1053/hupa.2001.21558
    • (2001) Hum Pathol , vol.32 , pp. 163-168
    • Furuya, M.1    Ishikura, H.2    Nemori, R.3    Shibata, M.4    Fujimoto, S.5    Yoshiki, T.6
  • 25
    • 0036142697 scopus 로고    scopus 로고
    • Activated matrix metalloproteinase-2 - a potential marker of prognosis for epithelial ovarian cancer
    • doi:10.1006/gyno.2001.6477
    • Wu X, Li H, Kang L, Li L, Wang W, Shan B. Activated matrix metalloproteinase-2 - a potential marker of prognosis for epithelial ovarian cancer. Gynecol Oncol (2002) 84:126-34. doi:10.1006/gyno.2001.6477
    • (2002) Gynecol Oncol , vol.84 , pp. 126-134
    • Wu, X.1    Li, H.2    Kang, L.3    Li, L.4    Wang, W.5    Shan, B.6
  • 26
    • 0141728381 scopus 로고    scopus 로고
    • Increased expression of tissue inhibitor of metalloproteinase-2 in clear cell carcinoma of the ovary
    • doi:10.1093/molehr/gag074
    • Okamoto T, Niu R, Yamada S. Increased expression of tissue inhibitor of metalloproteinase-2 in clear cell carcinoma of the ovary. Mol Hum Reprod (2003) 9:569-75. doi:10.1093/molehr/gag074
    • (2003) Mol Hum Reprod , vol.9 , pp. 569-575
    • Okamoto, T.1    Niu, R.2    Yamada, S.3
  • 27
    • 0842332135 scopus 로고    scopus 로고
    • Prognostic significance of stromal metalloproteinase-2 in ovarian adenocarcinoma and its relation to carcinoma progression
    • doi:10.1016/j.ygyno.2003.11.011
    • Torng PL, Mao TL, Chan WY, Huang SC, Lin CT. Prognostic significance of stromal metalloproteinase-2 in ovarian adenocarcinoma and its relation to carcinoma progression. Gynecol Oncol (2004) 92:559-67. doi:10.1016/j.ygyno.2003.11.011
    • (2004) Gynecol Oncol , vol.92 , pp. 559-567
    • Torng, P.L.1    Mao, T.L.2    Chan, W.Y.3    Huang, S.C.4    Lin, C.T.5
  • 28
    • 33645676359 scopus 로고    scopus 로고
    • The clinical relevance of stromal matrix metalloproteinase expression in ovarian cancer
    • doi:10.1158/1078-0432.CCR-05-2338
    • Kamat AA, Fletcher M, Gruman LM, Mueller P, Lopez A, Landen CN Jr, et al. The clinical relevance of stromal matrix metalloproteinase expression in ovarian cancer. Clin Cancer Res (2006) 12:1707-14. doi:10.1158/1078-0432.CCR-05-2338
    • (2006) Clin Cancer Res , vol.12 , pp. 1707-1714
    • Kamat, A.A.1    Fletcher, M.2    Gruman, L.M.3    Mueller, P.4    Lopez, A.5    Landen Jr., C.N.6
  • 29
    • 33846212673 scopus 로고    scopus 로고
    • EphA2 overexpression is associated with angiogenesis in ovarian cancer
    • doi:10.1002/cncr.22415
    • Lin YG, Han LY, Kamat AA, Merritt WM, Landen CN, Deavers MT, et al. EphA2 overexpression is associated with angiogenesis in ovarian cancer. Cancer (2007) 109:332-40. doi:10.1002/cncr.22415
    • (2007) Cancer , vol.109 , pp. 332-340
    • Lin, Y.G.1    Han, L.Y.2    Kamat, A.A.3    Merritt, W.M.4    Landen, C.N.5    Deavers, M.T.6
  • 30
    • 36448962792 scopus 로고    scopus 로고
    • Prognostic significance of extracellular matrix metalloproteinase inducer and matrix metalloproteinase 2 in epithelial ovarian cancer
    • doi:10.1159/000110426
    • Sillanpää S, Anttila M, Suhonen K, Hämäläinen K, Turpeenniemi-Hujanen T, Puistola U, et al. Prognostic significance of extracellular matrix metalloproteinase inducer and matrix metalloproteinase 2 in epithelial ovarian cancer. Tumour Biol (2007) 28:280-9. doi:10.1159/000110426
    • (2007) Tumour Biol , vol.28 , pp. 280-289
    • Sillanpää, S.1    Anttila, M.2    Suhonen, K.3    Hämäläinen, K.4    Turpeenniemi-Hujanen, T.5    Puistola, U.6
  • 31
    • 33846390422 scopus 로고    scopus 로고
    • Prognostic significance of matrix metalloproteinase-9 (MMP-9) in epithelial ovarian cancer
    • doi:10.1016/j. ygyno. 2006. 09. 004
    • Sillanpää S, Anttila M, Voutilainen K, Ropponen K, Turpeenniemi-Hujanen T, Puistola U, et al. Prognostic significance of matrix metalloproteinase-9 (MMP-9) in epithelial ovarian cancer. Gynecol Oncol (2007) 104:296-303. doi:10.1016/j.ygyno.2006.09.004
    • (2007) Gynecol Oncol , vol.104 , pp. 296-303
    • Sillanpää, S.1    Anttila, M.2    Voutilainen, K.3    Ropponen, K.4    Turpeenniemi-Hujanen, T.5    Puistola, U.6
  • 32
    • 40449126213 scopus 로고    scopus 로고
    • Role of immunohistochemical overexpression of matrix metalloproteinases MMP-2 and MMP-11 in the prognosis of death by ovarian cancer
    • doi:10.1309/49LA9XCBGWJ8F2KM
    • Périgny M, Bairati I, Harvey I, Beauchemin M, Harel F, Plante M, et al. Role of immunohistochemical overexpression of matrix metalloproteinases MMP-2 and MMP-11 in the prognosis of death by ovarian cancer. Am J Clin Pathol (2008) 129:226-31. doi:10.1309/49LA9XCBGWJ8F2KM
    • (2008) Am J Clin Pathol , vol.129 , pp. 226-231
    • Périgny, M.1    Bairati, I.2    Harvey, I.3    Beauchemin, M.4    Harel, F.5    Plante, M.6
  • 33
    • 84865849647 scopus 로고    scopus 로고
    • Enhanced immunoreactivity of TIMP-2 in the stromal compartment of tumor as a marker of favorable prognosis in ovarian cancer patients
    • doi:10.1369/0022155412446978
    • Hałon A, Nowak-Markwitz E, Donizy P, Matkowski R, Maciejczyk A, Gansukh T, et al. Enhanced immunoreactivity of TIMP-2 in the stromal compartment of tumor as a marker of favorable prognosis in ovarian cancer patients. J Histochem Cytochem (2012) 60:491-501. doi:10.1369/0022155412446978
    • (2012) J Histochem Cytochem , vol.60 , pp. 491-501
    • Hałon, A.1    Nowak-Markwitz, E.2    Donizy, P.3    Matkowski, R.4    Maciejczyk, A.5    Gansukh, T.6
  • 34
    • 84856573452 scopus 로고    scopus 로고
    • Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer
    • doi:10.3892/or.2011.1608
    • Brun JL, Cortez A, Lesieur B, Uzan S, Rouzier R, Daraï E. Expression of MMP-2, -7, -9, MT1-MMP and TIMP-1 and -2 has no prognostic relevance in patients with advanced epithelial ovarian cancer. Oncol Rep (2012) 27:1049-57. doi:10.3892/or.2011.1608
    • (2012) Oncol Rep , vol.27 , pp. 1049-1057
    • Brun, J.L.1    Cortez, A.2    Lesieur, B.3    Uzan, S.4    Rouzier, R.5    Daraï, E.6
  • 35
    • 84881273948 scopus 로고    scopus 로고
    • The role of p53 protein and MMP-2 tumor/stromal cells expression on progressive growth of ovarian neoplasms
    • doi:10.3109/07357907.2013.820320
    • Grelewski PG, Bar JK. The role of p53 protein and MMP-2 tumor/stromal cells expression on progressive growth of ovarian neoplasms. Cancer Invest (2013) 31:472-9. doi:10.3109/07357907.2013.820320
    • (2013) Cancer Invest , vol.31 , pp. 472-479
    • Grelewski, P.G.1    Bar, J.K.2
  • 36
    • 0344321892 scopus 로고    scopus 로고
    • EMMPRIN (extracellular matrix metalloproteinase inducer) is a novel marker of poor outcome in serous ovarian carcinoma
    • doi:10.1023/A:1022696012668
    • Davidson B, Goldberg I, Berner A, Kristensen GB, Reich R. EMMPRIN (extracellular matrix metalloproteinase inducer) is a novel marker of poor outcome in serous ovarian carcinoma. Clin Exp Metastasis (2003) 20:161-9. doi:10.1023/A:1022696012668
    • (2003) Clin Exp Metastasis , vol.20 , pp. 161-169
    • Davidson, B.1    Goldberg, I.2    Berner, A.3    Kristensen, G.B.4    Reich, R.5
  • 37
    • 78649327877 scopus 로고    scopus 로고
    • Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression
    • doi:10.1007/s10585-010-9345-9
    • Chen H, Wang L, Beretov J, Hao J, Xiao W, Li Y. Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression. Clin Exp Metastasis (2010) 27:557-69. doi:10.1007/s10585-010-9345-9
    • (2010) Clin Exp Metastasis , vol.27 , pp. 557-569
    • Chen, H.1    Wang, L.2    Beretov, J.3    Hao, J.4    Xiao, W.5    Li, Y.6
  • 38
    • 0036906177 scopus 로고    scopus 로고
    • uPAR: a versatile signalling orchestrator
    • doi:10.1038/nrm977
    • Blasi F, Carmeliet P. uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol (2002) 3:932-42. doi:10.1038/nrm977
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 932-942
    • Blasi, F.1    Carmeliet, P.2
  • 39
    • 3042685205 scopus 로고    scopus 로고
    • The urokinase plasminogen activator system: a rich source of tumour markers for the individualized management of patients with cancer
    • doi:10.1016/j.clinbiochem.2004.05.013
    • Duffy MJ, Duggan C. The urokinase plasminogen activator system: a rich source of tumour markers for the individualized management of patients with cancer. Clin Biochem (2004) 37:541-8. doi:10.1016/j.clinbiochem.2004.05.013
    • (2004) Clin Biochem , vol.37 , pp. 541-548
    • Duffy, M.J.1    Duggan, C.2
  • 40
    • 0031769894 scopus 로고    scopus 로고
    • High tissue content of urokinase plasminogen activator (u-PA) is associated with high stromal expression of u-PA mRNA in poorly differentiated serous ovarian carcinoma
    • doi:10. 1002/(SICI)1097-0215(19981218)79:6<588::AID-IJC6>3.0.CO;2-W
    • Borgfeldt C, Casslén B, Liu CL, Hansson S, Lecander I, Astedt B. High tissue content of urokinase plasminogen activator (u-PA) is associated with high stromal expression of u-PA mRNA in poorly differentiated serous ovarian carcinoma. Int J Cancer (1998) 79:588-95. doi:10.1002/(SICI)1097-0215(19981218)79:6<588::AID-IJC6>3.0.CO;2-W
    • (1998) Int J Cancer , vol.79 , pp. 588-595
    • Borgfeldt, C.1    Casslén, B.2    Liu, C.L.3    Hansson, S.4    Lecander, I.5    Astedt, B.6
  • 41
    • 0035874046 scopus 로고    scopus 로고
    • Dedifferentiation of serous ovarian cancer from cystic to solid tumors is associated with increased expression of mRNA for urokinase plasminogen activator (uPA), its receptor (uPAR) and its inhibitor (PAI-1)
    • doi:10.1002/ijc.1215
    • Borgfeldt C, Hansson SR, Gustavsson B, Måsbäck A, Casslén B. Dedifferentiation of serous ovarian cancer from cystic to solid tumors is associated with increased expression of mRNA for urokinase plasminogen activator (uPA), its receptor (uPAR) and its inhibitor (PAI-1). Int J Cancer (2001) 92:497-502. doi:10.1002/ijc.1215
    • (2001) Int J Cancer , vol.92 , pp. 497-502
    • Borgfeldt, C.1    Hansson, S.R.2    Gustavsson, B.3    Måsbäck, A.4    Casslén, B.5
  • 42
    • 67549104876 scopus 로고    scopus 로고
    • Expression of urokinase plasminogen activator and its receptor in advanced epithelial ovarian cancer patients
    • doi:10.1016/j.ygyno.2009.04.031
    • Wang L, Madigan MC, Chen H, Liu F, Patterson KI, Beretov J, et al. Expression of urokinase plasminogen activator and its receptor in advanced epithelial ovarian cancer patients. Gynecol Oncol (2009) 114:265-72. doi:10.1016/j.ygyno.2009.04.031
    • (2009) Gynecol Oncol , vol.114 , pp. 265-272
    • Wang, L.1    Madigan, M.C.2    Chen, H.3    Liu, F.4    Patterson, K.I.5    Beretov, J.6
  • 43
    • 84860611297 scopus 로고    scopus 로고
    • Differential roles of uPAR in peritoneal ovarian carcinomatosis
    • doi:10.1593/neo.12442
    • Al-Hassan NN, Behzadian A, Caldwell R, Ivanova VS, Syed V, Motamed K, et al. Differential roles of uPAR in peritoneal ovarian carcinomatosis. Neoplasia (2012) 14:259-70. doi:10.1593/neo.12442
    • (2012) Neoplasia , vol.14 , pp. 259-270
    • Al-Hassan, N.N.1    Behzadian, A.2    Caldwell, R.3    Ivanova, V.S.4    Syed, V.5    Motamed, K.6
  • 44
    • 79961127256 scopus 로고    scopus 로고
    • Prostate derived ETS factor (PDEF): a putative tumor metastasis suppressor
    • doi:10.1016/j.canlet.2011.06.011
    • Steffan JJ, Koul HK. Prostate derived ETS factor (PDEF): a putative tumor metastasis suppressor. Cancer Lett (2011) 310:109-17. doi:10.1016/j.canlet.2011.06.011
    • (2011) Cancer Lett , vol.310 , pp. 109-117
    • Steffan, J.J.1    Koul, H.K.2
  • 46
    • 0037386973 scopus 로고    scopus 로고
    • PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma
    • Davidson B, Goldberg I, Gotlieb WH, Kopolovic J, Ben-Baruch G, Reich R. PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma. Clin Cancer Res (2003) 9:1412-9.
    • (2003) Clin Cancer Res , vol.9 , pp. 1412-1419
    • Davidson, B.1    Goldberg, I.2    Gotlieb, W.H.3    Kopolovic, J.4    Ben-Baruch, G.5    Reich, R.6
  • 47
    • 0031769373 scopus 로고    scopus 로고
    • Immunoradiometric and immunohistochemical analysis of cathepsin D in ovarian cancer: lack of association with clinical outcome
    • doi:10.1038/bjc.1998.737
    • Ferrandina G, Scambia G, Fagotti A, D'Agostino G, Benedetti Panici P, Carbone A, et al. Immunoradiometric and immunohistochemical analysis of cathepsin D in ovarian cancer: lack of association with clinical outcome. Br J Cancer (1998) 78:1645-52. doi:10.1038/bjc.1998.737
    • (1998) Br J Cancer , vol.78 , pp. 1645-1652
    • Ferrandina, G.1    Scambia, G.2    Fagotti, A.3    D'Agostino, G.4    Benedetti Panici, P.5    Carbone, A.6
  • 48
    • 0032764064 scopus 로고    scopus 로고
    • The significance of metastasis-related factors cathepsin-D and nm23 in advanced ovarian cancer
    • doi:10.1023/A:1008352502465
    • Baekelandt M, Holm R, Tropé CG, Nesland JM, Kristensen GB. The significance of metastasis-related factors cathepsin-D and nm23 in advanced ovarian cancer. Ann Oncol (1999) 10:1335-41. doi:10.1023/A:1008352502465
    • (1999) Ann Oncol , vol.10 , pp. 1335-1341
    • Baekelandt, M.1    Holm, R.2    Tropé, C.G.3    Nesland, J.M.4    Kristensen, G.B.5
  • 49
    • 0842332175 scopus 로고    scopus 로고
    • Cathepsin D in ovarian cancer: prognostic value and correlation with p53 expression and microvessel density
    • doi:10.1016/j.ygyno.2003.11.016
    • Lösch A, Schindl M, Kohlberger P, Lahodny J, Breitenecker G, Horvat R, et al. Cathepsin D in ovarian cancer: prognostic value and correlation with p53 expression and microvessel density. Gynecol Oncol (2004) 92:545-52. doi:10.1016/j.ygyno.2003.11.016
    • (2004) Gynecol Oncol , vol.92 , pp. 545-552
    • Lösch, A.1    Schindl, M.2    Kohlberger, P.3    Lahodny, J.4    Breitenecker, G.5    Horvat, R.6
  • 50
    • 1342321832 scopus 로고    scopus 로고
    • The role of cathepsin B and cystatin C in the mechanisms of invasion by ovarian cancer
    • doi:10.1016/j.ygyno.2003.11.017
    • Nishikawa H, Ozaki Y, Nakanishi T, Blomgren K, Tada T, Arakawa A, et al. The role of cathepsin B and cystatin C in the mechanisms of invasion by ovarian cancer. Gynecol Oncol (2004) 92:881-6. doi:10.1016/j.ygyno.2003.11.017
    • (2004) Gynecol Oncol , vol.92 , pp. 881-886
    • Nishikawa, H.1    Ozaki, Y.2    Nakanishi, T.3    Blomgren, K.4    Tada, T.5    Arakawa, A.6
  • 51
    • 14644394954 scopus 로고    scopus 로고
    • Kallikrein 4 expression is up-regulated in epithelial ovarian carcinoma cells in effusions
    • doi:10.1309/PTBB5BPCKX8K9V69
    • Davidson B, Xi Z, Klokk TI, Tropé CG, Dørum A, Scheistrøen M, et al. Kallikrein 4 expression is up-regulated in epithelial ovarian carcinoma cells in effusions. Am J Clin Pathol (2005) 123:360-8. doi:10.1309/PTBB5BPCKX8K9V69
    • (2005) Am J Clin Pathol , vol.123 , pp. 360-368
    • Davidson, B.1    Xi, Z.2    Klokk, T.I.3    Tropé, C.G.4    Dørum, A.5    Scheistrøen, M.6
  • 52
    • 0030062793 scopus 로고    scopus 로고
    • Expression of mRNAs for type I and type III procollagens in serous ovarian cystadenomas and cystadenocarcinomas
    • Kauppila S, Saarela J, Stenbäck F, Risteli J, Kauppila A, Risteli L. Expression of mRNAs for type I and type III procollagens in serous ovarian cystadenomas and cystadenocarcinomas. Am J Pathol (1996) 148:539-48.
    • (1996) Am J Pathol , vol.148 , pp. 539-548
    • Kauppila, S.1    Saarela, J.2    Stenbäck, F.3    Risteli, J.4    Kauppila, A.5    Risteli, L.6
  • 53
    • 0028896132 scopus 로고
    • Immunohistochemical study of type I collagen and type I pN-collagen in benign and malignant ovarian neoplasms
    • doi:10. 1002/1097-0142(19950215)75:4<1010::AID-CNCR2820750417>3.0.CO;2-O
    • Zhu GG, Risteli L, Mäkinen M, Risteli J, Kauppila A, Stenbäck F. Immunohistochemical study of type I collagen and type I pN-collagen in benign and malignant ovarian neoplasms. Cancer (1995) 75:1010-7. doi:10.1002/1097-0142(19950215)75:4<1010::AID-CNCR2820750417>3.0.CO;2-O
    • (1995) Cancer , vol.75 , pp. 1010-1017
    • Zhu, G.G.1    Risteli, L.2    Mäkinen, M.3    Risteli, J.4    Kauppila, A.5    Stenbäck, F.6
  • 54
    • 0031894473 scopus 로고    scopus 로고
    • Identification of oncofetal fibronectin in patients with advanced epithelial ovarian cancer: detection in ascitic fluid and localization to primary sites and metastatic implants
    • doi:10. 1002/(SICI)1097-0142(19980101)82:1<152::AID-CNCR19>3.0.CO;2-1
    • Menzin AW, Loret de Mola JR, Bilker WB, Wheeler JE, Rubin SC, Feinberg RF. Identification of oncofetal fibronectin in patients with advanced epithelial ovarian cancer: detection in ascitic fluid and localization to primary sites and metastatic implants. Cancer (1998) 82:152-8. doi:10.1002/(SICI)1097-0142(19980101)82:1<152::AID-CNCR19>3.0.CO;2-1
    • (1998) Cancer , vol.82 , pp. 152-158
    • Menzin, A.W.1    Loret De Mola, J.R.2    Bilker, W.B.3    Wheeler, J.E.4    Rubin, S.C.5    Feinberg, R.F.6
  • 55
    • 0031768032 scopus 로고    scopus 로고
    • Increased immunostaining of fibulin-1, an estrogen-regulated protein in the stroma of human ovarian epithelial tumors
    • doi:10. 1016/S0002-9440(10)65746-X
    • Roger P, Pujol P, Lucas A, Baldet P, Rochefort H. Increased immunostaining of fibulin-1, an estrogen-regulated protein in the stroma of human ovarian epithelial tumors. Am J Pathol (1998) 153:1579-88. doi:10.1016/S0002-9440(10)65746-X
    • (1998) Am J Pathol , vol.153 , pp. 1579-1588
    • Roger, P.1    Pujol, P.2    Lucas, A.3    Baldet, P.4    Rochefort, H.5
  • 56
    • 78649402489 scopus 로고    scopus 로고
    • Cytoplasmic and stromal expression of laminin γ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type
    • doi:10.3892/or_00001019
    • Okuma E, Ohishi Y, Oda Y, Aishima S, Kurihara S, Nishimura I, et al. Cytoplasmic and stromal expression of laminin γ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type. Oncol Rep (2010) 24:1569-76. doi:10.3892/or_00001019
    • (2010) Oncol Rep , vol.24 , pp. 1569-1576
    • Okuma, E.1    Ohishi, Y.2    Oda, Y.3    Aishima, S.4    Kurihara, S.5    Nishimura, I.6
  • 57
    • 61449524264 scopus 로고    scopus 로고
    • Relation between laminin-5 gamma 2 chain and cell surface metalloproteinase MT1-MMP in clear cell carcinoma of the ovary
    • doi:10.1097/PGP.0b013e3181808021
    • Kato N, Motoyama T. Relation between laminin-5 gamma 2 chain and cell surface metalloproteinase MT1-MMP in clear cell carcinoma of the ovary. Int J Gynecol Pathol (2009) 28:49-54. doi:10.1097/PGP.0b013e3181808021
    • (2009) Int J Gynecol Pathol , vol.28 , pp. 49-54
    • Kato, N.1    Motoyama, T.2
  • 58
    • 0037344258 scopus 로고    scopus 로고
    • Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin
    • doi:10.1097/01.LAB.0000059949.01480.40
    • van den Brûle F, Califice S, Garnier F, Fernandez PL, Berchuck A, Castronovo V. Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin. Lab Invest (2003) 83:377-86. doi:10.1097/01.LAB.0000059949.01480.40
    • (2003) Lab Invest , vol.83 , pp. 377-386
    • Van Den Brûle, F.1    Califice, S.2    Garnier, F.3    Fernandez, P.L.4    Berchuck, A.5    Castronovo, V.6
  • 59
    • 0344873647 scopus 로고    scopus 로고
    • Expression of the 67 kDa laminin receptor and the alpha6 integrin subunit in serous ovarian carcinoma
    • doi:10. 1023/A:1027340208536
    • Givant-Horwitz V, Davidson B, van de Putte G, Dong HP, Goldberg I, Amir S, et al. Expression of the 67 kDa laminin receptor and the alpha6 integrin subunit in serous ovarian carcinoma. Clin Exp Metastasis (2003) 20:599-609. doi:10.1023/A:1027340208536
    • (2003) Clin Exp Metastasis , vol.20 , pp. 599-609
    • Givant-Horwitz, V.1    Davidson, B.2    van de Putte, G.3    Dong, H.P.4    Goldberg, I.5    Amir, S.6
  • 60
    • 0035542949 scopus 로고    scopus 로고
    • Alphav integrin expression is a novel marker of poor prognosis in advanced-stage ovarian carcinoma
    • Goldberg I, Davidson B, Reich R, Gotlieb WH, Ben-Baruch G, Bryne M, et al. Alphav integrin expression is a novel marker of poor prognosis in advanced-stage ovarian carcinoma. Clin Cancer Res (2001) 7:4073-9.
    • (2001) Clin Cancer Res , vol.7 , pp. 4073-4079
    • Goldberg, I.1    Davidson, B.2    Reich, R.3    Gotlieb, W.H.4    Ben-Baruch, G.5    Bryne, M.6
  • 61
    • 0042922958 scopus 로고    scopus 로고
    • AlphaV- and beta1-integrin subunits are commonly expressed in malignant effusions from ovarian carcinoma patients
    • doi:10. 1016/S0090-8258(03)00321-4
    • Davidson B, Goldberg I, Reich R, Tell L, Dong HP, Trope CG, et al. AlphaV- and beta1-integrin subunits are commonly expressed in malignant effusions from ovarian carcinoma patients. Gynecol Oncol (2003) 90:248-57. doi:10.1016/S0090-8258(03)00321-4
    • (2003) Gynecol Oncol , vol.90 , pp. 248-257
    • Davidson, B.1    Goldberg, I.2    Reich, R.3    Tell, L.4    Dong, H.P.5    Trope, C.G.6
  • 62
    • 0034843631 scopus 로고    scopus 로고
    • Expression of angiogenesis-related genes in ovarian carcinoma - a clinicopathologic study
    • doi:10.1023/A:1011858225144
    • Davidson B, Goldberg I, Kopolovic J, Gotlieb WH, Givant-Horwitz V, Nesland JM, et al. Expression of angiogenesis-related genes in ovarian carcinoma - a clinicopathologic study. Clin Exp Metastasis (2000) 18:501-7. doi:10.1023/A:1011858225144
    • (2000) Clin Exp Metastasis , vol.18 , pp. 501-507
    • Davidson, B.1    Goldberg, I.2    Kopolovic, J.3    Gotlieb, W.H.4    Givant-Horwitz, V.5    Nesland, J.M.6
  • 63
    • 0036202096 scopus 로고    scopus 로고
    • Interleukin-8 and vascular endothelial growth factor mRNA and protein levels are down-regulated in ovarian carcinoma cells in serous effusions
    • doi:10.1023/A:1014582911680
    • Davidson B, Reich R, Kopolovic J, Berner A, Nesland JM, Kristensen GB, et al. Interleukin-8 and vascular endothelial growth factor mRNA and protein levels are down-regulated in ovarian carcinoma cells in serous effusions. Clin Exp Metastasis (2002) 19:135-44. doi:10.1023/A:1014582911680
    • (2002) Clin Exp Metastasis , vol.19 , pp. 135-144
    • Davidson, B.1    Reich, R.2    Kopolovic, J.3    Berner, A.4    Nesland, J.M.5    Kristensen, G.B.6
  • 64
    • 0033831529 scopus 로고    scopus 로고
    • Upregulation of interleukin-8 and polarized epithelial expression of interleukin-8 receptor A in ovarian carcinomas
    • doi:10.1034/j.1600-0412.2000.079009777.x
    • Ivarsson K, Ekerydh A, Fyhr IM, Janson PO, Brännström M. Upregulation of interleukin-8 and polarized epithelial expression of interleukin-8 receptor A in ovarian carcinomas. Acta Obstet Gynecol Scand (2000) 79:777-84. doi:10.1034/j.1600-0412.2000.079009777.x
    • (2000) Acta Obstet Gynecol Scand , vol.79 , pp. 777-784
    • Ivarsson, K.1    Ekerydh, A.2    Fyhr, I.M.3    Janson, P.O.4    Brännström, M.5
  • 65
    • 0034574459 scopus 로고    scopus 로고
    • Expression of fibroblast growth factor (FGF)-8 isoforms and FGF receptors in human ovarian tumors
    • doi:10. 1002/1097-0215(20001201)88:5<718::AID-IJC6>3.0.CO;2-F
    • Valve E, Martikainen P, Seppänen J, Oksjoki S, Hinkka S, Anttila L, et al. Expression of fibroblast growth factor (FGF)-8 isoforms and FGF receptors in human ovarian tumors. Int J Cancer (2000) 88:718-25. doi:10.1002/1097-0215(20001201)88:5<718::AID-IJC6>3.0.CO;2-F
    • (2000) Int J Cancer , vol.88 , pp. 718-725
    • Valve, E.1    Martikainen, P.2    Seppänen, J.3    Oksjoki, S.4    Hinkka, S.5    Anttila, L.6
  • 67
    • 0035201527 scopus 로고    scopus 로고
    • Expression of CD44S and CD44v5 is more common in stage III than in stage I serous ovarian carcinomas
    • doi:10.1097/00022744-200112000-00004
    • Afify AM, Ferguson AW, Davila RM, Werness BA. Expression of CD44S and CD44v5 is more common in stage III than in stage I serous ovarian carcinomas. Appl Immunohistochem Mol Morphol (2001) 9:309-14. doi:10.1097/00022744-200112000-00004
    • (2001) Appl Immunohistochem Mol Morphol , vol.9 , pp. 309-314
    • Afify, A.M.1    Ferguson, A.W.2    Davila, R.M.3    Werness, B.A.4
  • 69
    • 10744226105 scopus 로고    scopus 로고
    • Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p
    • doi:10.1002/ijc.11733
    • Tuhkanen H, Anttila M, Kosma VM, Ylä-Herttuala S, Heinonen S, Kuronen A, et al. Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p. Int J Cancer (2004) 109:247-52. doi:10.1002/ijc.11733
    • (2004) Int J Cancer , vol.109 , pp. 247-252
    • Tuhkanen, H.1    Anttila, M.2    Kosma, V.M.3    Ylä-Herttuala, S.4    Heinonen, S.5    Kuronen, A.6
  • 70
    • 77953143395 scopus 로고    scopus 로고
    • Alternate mucoid and hyalinized stroma in clear cell carcinoma of the ovary: manifestation of serial stromal remodeling
    • doi:10.1038/modpathol.2010.75
    • Kato N, Takeda J, Fukase M, Motoyama T. Alternate mucoid and hyalinized stroma in clear cell carcinoma of the ovary: manifestation of serial stromal remodeling. Mod Pathol (2010) 23:881-8. doi:10.1038/modpathol.2010.75
    • (2010) Mod Pathol , vol.23 , pp. 881-888
    • Kato, N.1    Takeda, J.2    Fukase, M.3    Motoyama, T.4
  • 71
    • 84867875591 scopus 로고    scopus 로고
    • Hyalinized stroma in clear cell carcinoma of the ovary: how is it formed?
    • doi:10.1016/j.humpath.2012.02.012
    • Kato N, Takeda J, Fukase M, Motoyama T. Hyalinized stroma in clear cell carcinoma of the ovary: how is it formed? Hum Pathol (2012) 43:2041-6. doi:10.1016/j.humpath.2012.02.012
    • (2012) Hum Pathol , vol.43 , pp. 2041-2046
    • Kato, N.1    Takeda, J.2    Fukase, M.3    Motoyama, T.4
  • 72
    • 79957605232 scopus 로고    scopus 로고
    • Proteoglycans in cancer biology, tumour microenvironment and angiogenesis
    • doi:10.1111/j.1582-4934.2010.01236.x
    • Iozzo RV, Sanderson RD. Proteoglycans in cancer biology, tumour microenvironment and angiogenesis. J Cell Mol Med (2011) 15:1013-31. doi:10.1111/j.1582-4934.2010.01236.x
    • (2011) J Cell Mol Med , vol.15 , pp. 1013-1031
    • Iozzo, R.V.1    Sanderson, R.D.2
  • 73
    • 84873029601 scopus 로고    scopus 로고
    • An introduction to proteoglycans and their localization
    • doi:10.1369/0022155412464638
    • Couchman JR, Pataki CA. An introduction to proteoglycans and their localization. J Histochem Cytochem (2012) 60:885-97. doi:10.1369/0022155412464638
    • (2012) J Histochem Cytochem , vol.60 , pp. 885-897
    • Couchman, J.R.1    Pataki, C.A.2
  • 74
    • 4143058069 scopus 로고    scopus 로고
    • Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer
    • doi:10.1158/1078-0432.CCR-03-0103
    • Davies EJ, Blackhall FH, Shanks JH, David G, McGown AT, Swindell R, et al. Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer. Clin Cancer Res (2004) 10:5178-86. doi:10.1158/1078-0432.CCR-03-0103
    • (2004) Clin Cancer Res , vol.10 , pp. 5178-5186
    • Davies, E.J.1    Blackhall, F.H.2    Shanks, J.H.3    David, G.4    McGown, A.T.5    Swindell, R.6
  • 75
    • 77949451668 scopus 로고    scopus 로고
    • Clinical significance of syndecan-1 and versican expression in human epithelial ovarian cancer
    • doi:10.3892/or_00000715
    • Kusumoto T, Kodama J, Seki N, Nakamura K, Hongo A, Hiramatsu Y. Clinical significance of syndecan-1 and versican expression in human epithelial ovarian cancer. Oncol Rep (2010) 23:917-25. doi:10.3892/or_00000715
    • (2010) Oncol Rep , vol.23 , pp. 917-925
    • Kusumoto, T.1    Kodama, J.2    Seki, N.3    Nakamura, K.4    Hongo, A.5    Hiramatsu, Y.6
  • 76
    • 77956652578 scopus 로고    scopus 로고
    • Up-regulation of stromal versican expression in advanced stage serous ovarian cancer
    • doi:10.1016/j.ygyno.2010.05.029
    • Ghosh S, Albitar L, LeBaron R, Welch WR, Samimi G, Birrer MJ, et al. Up-regulation of stromal versican expression in advanced stage serous ovarian cancer. Gynecol Oncol (2010) 119:114-20. doi:10.1016/j.ygyno.2010.05.029
    • (2010) Gynecol Oncol , vol.119 , pp. 114-120
    • Ghosh, S.1    Albitar, L.2    LeBaron, R.3    Welch, W.R.4    Samimi, G.5    Birrer, M.J.6
  • 77
    • 0142090697 scopus 로고    scopus 로고
    • Versican in epithelial ovarian cancer: relation to hyaluronan, clinicopathologic factors and prognosis
    • doi:10.1002/ijc.11423
    • Voutilainen K, Anttila M, Sillanpää S, Tammi R, Tammi M, Saarikoski S, et al. Versican in epithelial ovarian cancer: relation to hyaluronan, clinicopathologic factors and prognosis. Int J Cancer (2003) 107:359-64. doi:10.1002/ijc.11423
    • (2003) Int J Cancer , vol.107 , pp. 359-364
    • Voutilainen, K.1    Anttila, M.2    Sillanpää, S.3    Tammi, R.4    Tammi, M.5    Saarikoski, S.6
  • 78
    • 0036278883 scopus 로고    scopus 로고
    • The expression of decorin in human ovarian tumors
    • Nash MA, Deavers MT, Freedman RS. The expression of decorin in human ovarian tumors. Clin Cancer Res (2002) 8:1754-60.
    • (2002) Clin Cancer Res , vol.8 , pp. 1754-1760
    • Nash, M.A.1    Deavers, M.T.2    Freedman, R.S.3
  • 79
    • 78649537056 scopus 로고    scopus 로고
    • Lysophosphatidic acid-induced expression of periostin in stromal cells: prognostic relevance of periostin expression in epithelial ovarian cancer
    • doi:10.1002/ijc.25341
    • Choi KU, Yun JS, Lee IH, Heo SC, Shin SH, Jeon ES, et al. Lysophosphatidic acid-induced expression of periostin in stromal cells: prognostic relevance of periostin expression in epithelial ovarian cancer. Int J Cancer (2011) 128:332-42. doi:10.1002/ijc.25341
    • (2011) Int J Cancer , vol.128 , pp. 332-342
    • Choi, K.U.1    Yun, J.S.2    Lee, I.H.3    Heo, S.C.4    Shin, S.H.5    Jeon, E.S.6
  • 80
    • 84865787544 scopus 로고    scopus 로고
    • Molecular pathways: targeting the TGF-β pathway for cancer therapy
    • doi:10.1158/1078-0432.CCR-11-3224
    • Smith AL, Robin TP, Ford HL. Molecular pathways: targeting the TGF-β pathway for cancer therapy. Clin Cancer Res (2012) 18:4514-21. doi:10.1158/1078-0432.CCR-11-3224
    • (2012) Clin Cancer Res , vol.18 , pp. 4514-4521
    • Smith, A.L.1    Robin, T.P.2    Ford, H.L.3
  • 81
    • 0034987333 scopus 로고    scopus 로고
    • Overexpression of latent transforming growth factor-beta 1 (TGF-beta 1) binding protein 1 (LTBP-1) in association with TGF-beta 1 in ovarian carcinoma
    • doi:10.1111/j.1349-7006.2001.tb01123.x
    • Higashi T, Sasagawa T, Inoue M, Oka R, Shuangying L, Saijoh K. Overexpression of latent transforming growth factor-beta 1 (TGF-beta 1) binding protein 1 (LTBP-1) in association with TGF-beta 1 in ovarian carcinoma. Jpn J Cancer Res (2001) 92:506-15. doi:10.1111/j.1349-7006.2001.tb01123.x
    • (2001) Jpn J Cancer Res , vol.92 , pp. 506-515
    • Higashi, T.1    Sasagawa, T.2    Inoue, M.3    Oka, R.4    Shuangying, L.5    Saijoh, K.6
  • 82
    • 84882661249 scopus 로고    scopus 로고
    • TGF-β modulates ovarian cancer invasion by upregulating CAF-derived versican in the tumor microenvironment
    • doi:10.1158/0008-5472.CAN-13-0023
    • Yeung TL, Leung CS, Wong KK, Samimi G, Thompson MS, Liu J, et al. TGF-β modulates ovarian cancer invasion by upregulating CAF-derived versican in the tumor microenvironment. Cancer Res (2013) 73:5016-28. doi:10.1158/0008-5472.CAN-13-0023
    • (2013) Cancer Res , vol.73 , pp. 5016-5028
    • Yeung, T.L.1    Leung, C.S.2    Wong, K.K.3    Samimi, G.4    Thompson, M.S.5    Liu, J.6
  • 83
    • 70349308726 scopus 로고    scopus 로고
    • CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer
    • doi:10.3892/or_00000469
    • Yao Q, Qu X, Yang Q, Wei M, Kong B. CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer. Oncol Rep (2009) 22:541-8. doi:10.3892/or_00000469
    • (2009) Oncol Rep , vol.22 , pp. 541-548
    • Yao, Q.1    Qu, X.2    Yang, Q.3    Wei, M.4    Kong, B.5
  • 84
    • 0033082311 scopus 로고    scopus 로고
    • Altered expression of transforming growth factor-beta ligands and receptors in primary and recurrent ovarian carcinoma
    • doi:10. 1002/(SICI)1097-0142(19990201)85:3<658::AID-CNCR16>3.0.CO;2-M
    • Bristow RE, Baldwin RL, Yamada SD, Korc M, Karlan BY. Altered expression of transforming growth factor-beta ligands and receptors in primary and recurrent ovarian carcinoma. Cancer (1999) 85:658-68. doi:10.1002/(SICI)1097-0142(19990201)85:3<658::AID-CNCR16>3.0.CO;2-M
    • (1999) Cancer , vol.85 , pp. 658-668
    • Bristow, R.E.1    Baldwin, R.L.2    Yamada, S.D.3    Korc, M.4    Karlan, B.Y.5
  • 85
    • 47949107815 scopus 로고    scopus 로고
    • The role of activin A and Akt/GSK signaling in ovarian tumor biology
    • doi:10.1210/en.2007-1584
    • Do TV, Kubba LA, Antenos M, Rademaker AW, Sturgis CD, Woodruff TK. The role of activin A and Akt/GSK signaling in ovarian tumor biology. Endocrinology (2008) 149:3809-16. doi:10.1210/en.2007-1584
    • (2008) Endocrinology , vol.149 , pp. 3809-3816
    • Do, T.V.1    Kubba, L.A.2    Antenos, M.3    Rademaker, A.W.4    Sturgis, C.D.5    Woodruff, T.K.6
  • 86
    • 0032880280 scopus 로고    scopus 로고
    • Activation of SPARC expression in reactive stroma associated with human epithelial ovarian cancer
    • doi:10.1006/gyno.1999.5552
    • Brown TJ, Shaw PA, Karp X, Huynh MH, Begley H, Ringuette MJ. Activation of SPARC expression in reactive stroma associated with human epithelial ovarian cancer. Gynecol Oncol (1999) 75:25-33. doi:10.1006/gyno.1999.5552
    • (1999) Gynecol Oncol , vol.75 , pp. 25-33
    • Brown, T.J.1    Shaw, P.A.2    Karp, X.3    Huynh, M.H.4    Begley, H.5    Ringuette, M.J.6
  • 87
    • 0033823150 scopus 로고    scopus 로고
    • Alterations in SPARC and VEGF immunoreactivity in epithelial ovarian cancer
    • doi:10.1006/gyno.2000.5894
    • Paley PJ, Goff BA, Gown AM, Greer BE, Sage EH. Alterations in SPARC and VEGF immunoreactivity in epithelial ovarian cancer. Gynecol Oncol (2000) 78:336-41. doi:10.1006/gyno.2000.5894
    • (2000) Gynecol Oncol , vol.78 , pp. 336-341
    • Paley, P.J.1    Goff, B.A.2    Gown, A.M.3    Greer, B.E.4    Sage, E.H.5
  • 88
    • 0033197939 scopus 로고    scopus 로고
    • Paracrine regulation of ovarian cancer by endothelin
    • doi:10. 1016/S0959-8049(99)
    • Moraitis S, Miller WR, Smyth JF, Langdon SP. Paracrine regulation of ovarian cancer by endothelin. Eur J Cancer (1999) 35:1381-7. doi:10.1016/S0959-8049(99)00131-8
    • (1999) Eur J Cancer , vol.35 , pp. 1381-1387
    • Moraitis, S.1    Miller, W.R.2    Smyth, J.F.3    Langdon, S.P.4
  • 89
    • 84867311680 scopus 로고    scopus 로고
    • Immunohistochemical expression of platelet-derived growth factor receptors in ovarian cancer patients with long-term follow-up
    • doi:10.1155/2012/851432/2012/851432
    • Madsen CV, Dahl Steffensen K, Waldstrøm M, Jakobsen A. Immunohistochemical expression of platelet-derived growth factor receptors in ovarian cancer patients with long-term follow-up. Patholog Res Int (2012) 2012:851432. doi:10.1155/2012/851432
    • (2012) Patholog Res Int
    • Madsen, C.V.1    Dahl Steffensen, K.2    Waldstrøm, M.3    Jakobsen, A.4
  • 90
    • 12244281813 scopus 로고    scopus 로고
    • The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer
    • Jones MB, Michener CM, Blanchette JO, Kuznetsov VA, Raffeld M, Serrero G, et al. The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer. Clin Cancer Res (2003) 9:44-51.
    • (2003) Clin Cancer Res , vol.9 , pp. 44-51
    • Jones, M.B.1    Michener, C.M.2    Blanchette, J.O.3    Kuznetsov, V.A.4    Raffeld, M.5    Serrero, G.6
  • 91
    • 2342596394 scopus 로고    scopus 로고
    • Granulin-epithelin precursor is a novel prognostic marker in epithelial ovarian carcinoma
    • doi:10.1002/cncr.20219
    • Davidson B, Alejandro E, Flørenes VA, Goderstad JM, Risberg B, Kristensen GB, et al. Granulin-epithelin precursor is a novel prognostic marker in epithelial ovarian carcinoma. Cancer (2004) 100:2139-47. doi:10.1002/cncr.20219
    • (2004) Cancer , vol.100 , pp. 2139-2147
    • Davidson, B.1    Alejandro, E.2    Flørenes, V.A.3    Goderstad, J.M.4    Risberg, B.5    Kristensen, G.B.6
  • 92
    • 0028148398 scopus 로고
    • Immunohistochemical localization of insulin-like growth factor 1 receptors in benign and malignant tissues of the female genital tract
    • doi:10.1159/000217897
    • Weigang B, Nap M, Bittl A, Jaeger W. Immunohistochemical localization of insulin-like growth factor 1 receptors in benign and malignant tissues of the female genital tract. Tumour Biol (1994) 15:236-46. doi:10.1159/000217897
    • (1994) Tumour Biol , vol.15 , pp. 236-246
    • Weigang, B.1    Nap, M.2    Bittl, A.3    Jaeger, W.4
  • 94
    • 77951605788 scopus 로고    scopus 로고
    • The Hox genes and their roles in oncogenesis
    • doi:10.1038/nrc2826
    • Shah N, Sukumar S. The Hox genes and their roles in oncogenesis. Nat Rev Cancer (2010) 10:361-71. doi:10.1038/nrc2826
    • (2010) Nat Rev Cancer , vol.10 , pp. 361-371
    • Shah, N.1    Sukumar, S.2
  • 95
    • 38449107286 scopus 로고    scopus 로고
    • HOXA7 in epithelial ovarian cancer: interrelationships between differentiation and clinical features
    • doi:10.1177/1933719107307781
    • Ota T, Gilks CB, Longacre T, Leung PC, Auersperg N. HOXA7 in epithelial ovarian cancer: interrelationships between differentiation and clinical features. Reprod Sci (2007) 14:605-14. doi:10.1177/1933719107307781
    • (2007) Reprod Sci , vol.14 , pp. 605-614
    • Ota, T.1    Gilks, C.B.2    Longacre, T.3    Leung, P.C.4    Auersperg, N.5
  • 96
    • 84867163385 scopus 로고    scopus 로고
    • HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts
    • doi:10.1172/JCI62229
    • Ko SY, Barengo N, Ladanyi A, Lee JS, Marini F, Lengyel E, et al. HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts. J Clin Invest (2012) 122:3603-17. doi:10.1172/JCI62229
    • (2012) J Clin Invest , vol.122 , pp. 3603-3617
    • Ko, S.Y.1    Barengo, N.2    Ladanyi, A.3    Lee, J.S.4    Marini, F.5    Lengyel, E.6
  • 97
    • 74749087064 scopus 로고    scopus 로고
    • The Müllerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial-stromal interactions
    • doi:10.1016/j.mce.2009.12.025
    • Ko SY, Lengyel E, Naora H. The Müllerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial-stromal interactions. Mol Cell Endocrinol (2010) 317:112-9. doi:10.1016/j.mce.2009.12.025
    • (2010) Mol Cell Endocrinol , vol.317 , pp. 112-119
    • Ko, S.Y.1    Lengyel, E.2    Naora, H.3
  • 98
    • 33646409018 scopus 로고    scopus 로고
    • Altered expression pattern of topoisomerase IIalpha in ovarian tumor epithelial and stromal cells after platinum-based chemotherapy
    • doi:10.1593/neo.05580
    • Chekerov R, Klaman I, Zafrakas M, Könsgen D, Mustea A, Petschke B, et al. Altered expression pattern of topoisomerase IIalpha in ovarian tumor epithelial and stromal cells after platinum-based chemotherapy. Neoplasia (2006) 8:38-45. doi:10.1593/neo.05580
    • (2006) Neoplasia , vol.8 , pp. 38-45
    • Chekerov, R.1    Klaman, I.2    Zafrakas, M.3    Könsgen, D.4    Mustea, A.5    Petschke, B.6
  • 99
    • 84878113852 scopus 로고    scopus 로고
    • VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer
    • doi:10.1016/j.molonc.2012.12.006
    • Gambaro K, Quinn MC, Wojnarowicz PM, Arcand SL, de Ladurantaye M, Barrès V, et al. VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer. Mol Oncol (2013) 7:513-30. doi:10.1016/j.molonc.2012.12.006
    • (2013) Mol Oncol , vol.7 , pp. 513-530
    • Gambaro, K.1    Quinn, M.C.2    Wojnarowicz, P.M.3    Arcand, S.L.4    de Ladurantaye, M.5    Barrès, V.6
  • 100
    • 70049095113 scopus 로고    scopus 로고
    • Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression
    • doi:10.1186/1471-2407-9-289
    • Tuhkanen H, Soini Y, Kosma VM, Anttila M, Sironen R, Hämäläinen K, et al. Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression. BMC Cancer (2009) 9:289. doi:10.1186/1471-2407-9-289
    • (2009) BMC Cancer , vol.9 , pp. 289
    • Tuhkanen, H.1    Soini, Y.2    Kosma, V.M.3    Anttila, M.4    Sironen, R.5    Hämäläinen, K.6
  • 101
    • 0033023190 scopus 로고    scopus 로고
    • The expression of CCAAT/enhancer binding protein (C/EBP) in the human ovary in vivo: specific increase in C/EBPbeta during epithelial tumour progression
    • doi:10.1038/sj.bjc.6690199
    • Sundfeldt K, Ivarsson K, Carlsson M, Enerbäck S, Janson PO, Brännström M, et al. The expression of CCAAT/enhancer binding protein (C/EBP) in the human ovary in vivo: specific increase in C/EBPbeta during epithelial tumour progression. Br J Cancer (1999) 79:1240-8. doi:10.1038/sj.bjc.6690199
    • (1999) Br J Cancer , vol.79 , pp. 1240-1248
    • Sundfeldt, K.1    Ivarsson, K.2    Carlsson, M.3    Enerbäck, S.4    Janson, P.O.5    Brännström, M.6
  • 102
    • 15244362098 scopus 로고    scopus 로고
    • Immunolocalization of nuclear transcription factors, DAX-1 and Ad4BP/SF-1, in human common epithelial ovarian tumors: correlations with StAR and steroidogenic enzymes in epithelial ovarian carcinoma
    • doi:10.1097/01.pgp.0000155075.75209.42
    • Abd-Elaziz M, Moriya T, Akahira J, Nakamura Y, Suzuki T, Sasano H. Immunolocalization of nuclear transcription factors, DAX-1 and Ad4BP/SF-1, in human common epithelial ovarian tumors: correlations with StAR and steroidogenic enzymes in epithelial ovarian carcinoma. Int J Gynecol Pathol (2005) 24:153-63. doi:10.1097/01.pgp.0000155075.75209.42
    • (2005) Int J Gynecol Pathol , vol.24 , pp. 153-163
    • Abd-Elaziz, M.1    Moriya, T.2    Akahira, J.3    Nakamura, Y.4    Suzuki, T.5    Sasano, H.6
  • 103
    • 42149091578 scopus 로고    scopus 로고
    • An immunohistochemical perspective of PPAR beta and one of its putative targets PDK1 in normal ovaries, benign and malignant ovarian tumours
    • doi:10.1038/sj.bjc.6604306
    • Ahmed N, Riley C, Quinn MA. An immunohistochemical perspective of PPAR beta and one of its putative targets PDK1 in normal ovaries, benign and malignant ovarian tumours. Br J Cancer (2008) 98:1415-24. doi:10.1038/sj.bjc.6604306
    • (2008) Br J Cancer , vol.98 , pp. 1415-1424
    • Ahmed, N.1    Riley, C.2    Quinn, M.A.3
  • 105
    • 38749148077 scopus 로고    scopus 로고
    • Ovarian cancers overexpress the antimicrobial protein hCAP-18 and its derivative LL-37 increases ovarian cancer cell proliferation and invasion
    • doi:10.1002/ijc.23186
    • Coffelt SB, Waterman RS, Florez L, Höner zu Bentrup K, Zwezdaryk KJ, Tomchuck SL, et al. Ovarian cancers overexpress the antimicrobial protein hCAP-18 and its derivative LL-37 increases ovarian cancer cell proliferation and invasion. Int J Cancer (2008) 122:1030-9. doi:10.1002/ijc.23186
    • (2008) Int J Cancer , vol.122 , pp. 1030-1039
    • Coffelt, S.B.1    Waterman, R.S.2    Florez, L.3    Höner Zu Bentrup, K.4    Zwezdaryk, K.J.5    Tomchuck, S.L.6
  • 106
    • 84890055236 scopus 로고    scopus 로고
    • Cancer cell-derived lymphotoxin mediates reciprocal tumour-stromal interactions in human ovarian cancer by inducing CXCL11 in fibroblasts
    • doi:10.1002/path.4258
    • Lau TS, Chung TK, Cheung TH, Chan LK, Cheung LW, Yim SF, et al. Cancer cell-derived lymphotoxin mediates reciprocal tumour-stromal interactions in human ovarian cancer by inducing CXCL11 in fibroblasts. J Pathol (2014) 232:43-56. doi:10.1002/path.4258
    • (2014) J Pathol , vol.232 , pp. 43-56
    • Lau, T.S.1    Chung, T.K.2    Cheung, T.H.3    Chan, L.K.4    Cheung, L.W.5    Yim, S.F.6
  • 108
    • 84880934991 scopus 로고    scopus 로고
    • Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors
    • doi:10.1016/j.bbrc.2013.06.089
    • Erez N, Glanz S, Raz Y, Avivi C, Barshack I. Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors. Biochem Biophys Res Commun (2013) 437:397-402. doi:10.1016/j.bbrc.2013.06.089
    • (2013) Biochem Biophys Res Commun , vol.437 , pp. 397-402
    • Erez, N.1    Glanz, S.2    Raz, Y.3    Avivi, C.4    Barshack, I.5
  • 109
    • 84875684114 scopus 로고    scopus 로고
    • Interleukin-1β promotes ovarian tumorigenesis through a p53/NF-κB-mediated inflammatory response in stromal fibroblasts
    • doi:10.1593/neo.121228
    • Schauer IG, Zhang J, Xing Z, Guo X, Mercado-Uribe I, Sood AK, et al. Interleukin-1β promotes ovarian tumorigenesis through a p53/NF-κB-mediated inflammatory response in stromal fibroblasts. Neoplasia (2013) 15:409-20. doi:10.1593/neo.121228
    • (2013) Neoplasia , vol.15 , pp. 409-420
    • Schauer, I.G.1    Zhang, J.2    Xing, Z.3    Guo, X.4    Mercado-Uribe, I.5    Sood, A.K.6
  • 110
    • 33750798741 scopus 로고    scopus 로고
    • The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
    • doi:10.1073/pnas.0605752103
    • Yang G, Rosen DG, Zhang Z, Bast RC Jr, Mills GB, Colacino JA, et al. The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc Natl Acad Sci U S A (2006) 103:16472-7. doi:10.1073/pnas.0605752103
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 16472-16477
    • Yang, G.1    Rosen, D.G.2    Zhang, Z.3    Bast Jr., R.C.4    Mills, G.B.5    Colacino, J.A.6
  • 111
    • 84877842742 scopus 로고    scopus 로고
    • Loss of function of ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis
    • doi:10.1073/pnas.1222079110
    • Acquati F, Lualdi M, Bertilaccio S, Monti L, Turconi G, Fabbri M, et al. Loss of function of ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis. Proc Natl Acad Sci U S A (2013) 110:8140-5. doi:10.1073/pnas.1222079110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 8140-8145
    • Acquati, F.1    Lualdi, M.2    Bertilaccio, S.3    Monti, L.4    Turconi, G.5    Fabbri, M.6
  • 112
    • 0030955478 scopus 로고    scopus 로고
    • Increased expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product P16INK4A in ovarian cancer is associated with progression and unfavourable prognosis
    • doi:10. 1002/(SICI)1097-0215(19970220)74:1<57::AID-IJC10>3.0.CO;2-F
    • Dong Y, Walsh MD, McGuckin MA, Gabrielli BG, Cummings MC, Wright RG, et al. Increased expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product P16INK4A in ovarian cancer is associated with progression and unfavourable prognosis. Int J Cancer (1997) 74:57-63. doi:10.1002/(SICI)1097-0215(19970220)74:1<57::AID-IJC10>3.0.CO;2-F
    • (1997) Int J Cancer , vol.74 , pp. 57-63
    • Dong, Y.1    Walsh, M.D.2    McGuckin, M.A.3    Gabrielli, B.G.4    Cummings, M.C.5    Wright, R.G.6
  • 113
    • 0035056377 scopus 로고    scopus 로고
    • Evaluation of chemoresistance markers in women with epithelial ovarian carcinoma
    • doi:10.1006/gyno.2000.6105
    • Goff BA, Paley PJ, Greer BE, Gown AM. Evaluation of chemoresistance markers in women with epithelial ovarian carcinoma. Gynecol Oncol (2001) 81:18-24. doi:10.1006/gyno.2000.6105
    • (2001) Gynecol Oncol , vol.81 , pp. 18-24
    • Goff, B.A.1    Paley, P.J.2    Greer, B.E.3    Gown, A.M.4
  • 114
    • 1342279512 scopus 로고    scopus 로고
    • Chemotherapy induces death receptor 5 in epithelial ovarian carcinoma
    • doi:10.1016/j.ygyno.2003.11.054
    • Arts HJ, de Jong S, Hollema H, ten Hoor K, van der Zee AG, de Vries EG. Chemotherapy induces death receptor 5 in epithelial ovarian carcinoma. Gynecol Oncol (2004) 92:794-800. doi:10.1016/j.ygyno.2003.11.054
    • (2004) Gynecol Oncol , vol.92 , pp. 794-800
    • Arts, H.J.1    de Jong, S.2    Hollema, H.3    ten Hoor, K.4    van der Zee, A.G.5    de Vries, E.G.6
  • 115
    • 29344473740 scopus 로고    scopus 로고
    • Perturbation of the tumor necrosis factor - related apoptosis-inducing ligand cascade in ovarian cancer: overexpression of FLIPL and deregulation of the functional receptors DR4 and DR5
    • doi:10.1158/1078-0432.CCR-05-1276
    • Horak P, Pils D, Kaider A, Pinter A, Elandt K, Sax C, et al. Perturbation of the tumor necrosis factor - related apoptosis-inducing ligand cascade in ovarian cancer: overexpression of FLIPL and deregulation of the functional receptors DR4 and DR5. Clin Cancer Res (2005) 11:8585-91. doi:10.1158/1078-0432.CCR-05-1276
    • (2005) Clin Cancer Res , vol.11 , pp. 8585-8591
    • Horak, P.1    Pils, D.2    Kaider, A.3    Pinter, A.4    Elandt, K.5    Sax, C.6
  • 116
    • 25144472553 scopus 로고    scopus 로고
    • Cytoplasmic HuR expression correlates with epithelial cancer cell but not with stromal cell cyclooxygenase-2 expression in mucinous ovarian carcinoma
    • doi:10.1016/j.ygyno.2005.04.047
    • Erkinheimo TL, Sivula A, Lassus H, Heinonen M, Furneaux H, Haglund C, et al. Cytoplasmic HuR expression correlates with epithelial cancer cell but not with stromal cell cyclooxygenase-2 expression in mucinous ovarian carcinoma. Gynecol Oncol (2005) 99:14-9. doi:10.1016/j.ygyno.2005.04.047
    • (2005) Gynecol Oncol , vol.99 , pp. 14-19
    • Erkinheimo, T.L.1    Sivula, A.2    Lassus, H.3    Heinonen, M.4    Furneaux, H.5    Haglund, C.6
  • 117
    • 33845671788 scopus 로고    scopus 로고
    • Ovarian epithelial cancer: a role for PGE2-synthesis and signalling in malignant transformation and progression
    • doi:10.1186/1476-4598-5-62
    • Rask K, Zhu Y, Wang W, Hedin L, Sundfeldt K. Ovarian epithelial cancer: a role for PGE2-synthesis and signalling in malignant transformation and progression. Mol Cancer (2006) 5:62. doi:10.1186/1476-4598-5-62
    • (2006) Mol Cancer , vol.5 , pp. 62
    • Rask, K.1    Zhu, Y.2    Wang, W.3    Hedin, L.4    Sundfeldt, K.5
  • 118
    • 0027250219 scopus 로고
    • Glutathione S-transferase expression in benign and malignant ovarian tumours
    • doi:10.1038/bjc.1993.321
    • Green JA, Robertson LJ, Clark AH. Glutathione S-transferase expression in benign and malignant ovarian tumours. Br J Cancer (1993) 68:235-9. doi:10.1038/bjc.1993.321
    • (1993) Br J Cancer , vol.68 , pp. 235-239
    • Green, J.A.1    Robertson, L.J.2    Clark, A.H.3
  • 119
    • 0036649145 scopus 로고    scopus 로고
    • Localisation of somatostatin and somatostatin receptors in benign and malignant ovarian tumours
    • doi:10.1038/sj.bjc.6600284
    • Hall GH, Turnbull LW, Richmond I, Helboe L, Atkin SL. Localisation of somatostatin and somatostatin receptors in benign and malignant ovarian tumours. Br J Cancer (2002) 87:86-90. doi:10.1038/sj.bjc.6600284
    • (2002) Br J Cancer , vol.87 , pp. 86-90
    • Hall, G.H.1    Turnbull, L.W.2    Richmond, I.3    Helboe, L.4    Atkin, S.L.5
  • 120
    • 84859990709 scopus 로고    scopus 로고
    • Expression of serotonin receptors 5-HT1A, 5-HT1B, 5-HT2B and 5-HT4 in ovary and in ovarian tumours
    • Henriksen R, Dizeyi N, Abrahamsson PA. Expression of serotonin receptors 5-HT1A, 5-HT1B, 5-HT2B and 5-HT4 in ovary and in ovarian tumours. Anticancer Res (2012) 32:1361-6.
    • (2012) Anticancer Res , vol.32 , pp. 1361-1366
    • Henriksen, R.1    Dizeyi, N.2    Abrahamsson, P.A.3
  • 121
    • 0031830265 scopus 로고    scopus 로고
    • Cellular distribution of retinoic acid receptor-alpha protein in serous adenocarcinomas of ovarian, tubal, and peritoneal origin: comparison with estrogen receptor status
    • doi:10. 1016/S0002-9440(10)
    • Katsetos CD, Stadnicka I, Boyd JC, Ehya H, Zheng S, Soprano CM, et al. Cellular distribution of retinoic acid receptor-alpha protein in serous adenocarcinomas of ovarian, tubal, and peritoneal origin: comparison with estrogen receptor status. Am J Pathol (1998) 153:469-80. doi:10.1016/S0002-9440(10)65590-3
    • (1998) Am J Pathol , vol.153 , pp. 469-480
    • Katsetos, C.D.1    Stadnicka, I.2    Boyd, J.C.3    Ehya, H.4    Zheng, S.5    Soprano, C.M.6
  • 122
    • 0037377621 scopus 로고    scopus 로고
    • Neutral endopeptidase/CD10 expression in the stroma of epithelial ovarian carcinoma
    • doi:10.1097/00004347-200304000-00010
    • Khin EE, Kikkawa F, Ino K, Suzuki T, Shibata K, Kajiyama H, et al. Neutral endopeptidase/CD10 expression in the stroma of epithelial ovarian carcinoma. Int J Gynecol Pathol (2003) 22:175-80. doi:10.1097/00004347-200304000-00010
    • (2003) Int J Gynecol Pathol , vol.22 , pp. 175-180
    • Khin, E.E.1    Kikkawa, F.2    Ino, K.3    Suzuki, T.4    Shibata, K.5    Kajiyama, H.6
  • 123
    • 0033757074 scopus 로고    scopus 로고
    • Decreased luteinizing hormone receptor mRNA expression in human ovarian epithelial cancer
    • doi:10.1006/gyno.2000.5928
    • Lu JJ, Zheng Y, Kang X, Yuan JM, Lauchlan SC, Pike MC, et al. Decreased luteinizing hormone receptor mRNA expression in human ovarian epithelial cancer. Gynecol Oncol (2000) 79:158-68. doi:10.1006/gyno.2000.5928
    • (2000) Gynecol Oncol , vol.79 , pp. 158-168
    • Lu, J.J.1    Zheng, Y.2    Kang, X.3    Yuan, J.M.4    Lauchlan, S.C.5    Pike, M.C.6
  • 124
    • 84864413214 scopus 로고    scopus 로고
    • Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures
    • doi:10.1186/1471-2407-12-329
    • Saw YT, Yang J, Ng SK, Liu S, Singh S, Singh M, et al. Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures. BMC Cancer (2012) 12:329. doi:10.1186/1471-2407-12-329
    • (2012) BMC Cancer , vol.12 , pp. 329
    • Saw, Y.T.1    Yang, J.2    Ng, S.K.3    Liu, S.4    Singh, S.5    Singh, M.6
  • 125
    • 84893178411 scopus 로고    scopus 로고
    • Class III β-tubulin overexpression within the tumor microenvironment is a prognostic biomarker for poor overall survival in ovarian cancer patients treated with neoadjuvant carboplatin/paclitaxel
    • doi:10.1007/s10585-013-9614-5
    • Roque DM, Buza N, Glasgow M, Bellone S, Bortolomai I, Gasparrini S, et al. Class III β-tubulin overexpression within the tumor microenvironment is a prognostic biomarker for poor overall survival in ovarian cancer patients treated with neoadjuvant carboplatin/paclitaxel. Clin Exp Metastasis (2014) 31:101-10. doi:10.1007/s10585-013-9614-5
    • (2014) Clin Exp Metastasis , vol.31 , pp. 101-110
    • Roque, D.M.1    Buza, N.2    Glasgow, M.3    Bellone, S.4    Bortolomai, I.5    Gasparrini, S.6
  • 126
    • 84887257847 scopus 로고    scopus 로고
    • Stromal-epithelial crosstalk provides a suitable microenvironment for the progression of ovarian cancer cells in vitro
    • doi:10.3109/07357907.2013.849723
    • Fu S, Dong L, Sun W, Xu Y, Gao L, Miao Y. Stromal-epithelial crosstalk provides a suitable microenvironment for the progression of ovarian cancer cells in vitro. Cancer Invest (2013) 31:616-24. doi:10.3109/07357907.2013.849723
    • (2013) Cancer Invest , vol.31 , pp. 616-624
    • Fu, S.1    Dong, L.2    Sun, W.3    Xu, Y.4    Gao, L.5    Miao, Y.6
  • 127
    • 42549152045 scopus 로고    scopus 로고
    • No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
    • doi:10.1038/ng.117
    • Qiu W, Hu M, Sridhar A, Opeskin K, Fox S, Shipitsin M, et al. No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat Genet (2008) 40:650-5. doi:10.1038/ng.117
    • (2008) Nat Genet , vol.40 , pp. 650-655
    • Qiu, W.1    Hu, M.2    Sridhar, A.3    Opeskin, K.4    Fox, S.5    Shipitsin, M.6
  • 128
    • 84855505679 scopus 로고    scopus 로고
    • EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy
    • doi:10.1002/gcc.21916
    • Kataoka F, Tsuda H, Arao T, Nishimura S, Tanaka H, Nomura H, et al. EGRI and FOSB gene expressions in cancer stroma are independent prognostic indicators for epithelial ovarian cancer receiving standard therapy. Genes Chromosomes Cancer (2012) 51:300-12. doi:10.1002/gcc.21916
    • (2012) Genes Chromosomes Cancer , vol.51 , pp. 300-312
    • Kataoka, F.1    Tsuda, H.2    Arao, T.3    Nishimura, S.4    Tanaka, H.5    Nomura, H.6
  • 129
    • 84871528926 scopus 로고    scopus 로고
    • MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer
    • doi:10.1158/2159-8290.CD-12-0206
    • Mitra AK, Zillhardt M, Hua Y, Tiwari P, Murmann AE, Peter ME, et al. MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov (2012) 2:1100-8. doi:10.1158/2159-8290.CD-12-0206
    • (2012) Cancer Discov , vol.2 , pp. 1100-1108
    • Mitra, A.K.1    Zillhardt, M.2    Hua, Y.3    Tiwari, P.4    Murmann, A.E.5    Peter, M.E.6
  • 130
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • doi:10.1038/ncb1596
    • Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol (2007) 9:654-9. doi:10.1038/ncb1596
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 131
    • 80054717963 scopus 로고    scopus 로고
    • Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts
    • doi:10.1016/j.ygyno.2011.08.005
    • Cho JA, Park H, Lim EH, Kim KH, Choi JS, Lee JH, et al. Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts. Gynecol Oncol (2011) 123:379-86. doi:10.1016/j.ygyno.2011.08.005
    • (2011) Gynecol Oncol , vol.123 , pp. 379-386
    • Cho, J.A.1    Park, H.2    Lim, E.H.3    Kim, K.H.4    Choi, J.S.5    Lee, J.H.6
  • 132
    • 84878723682 scopus 로고    scopus 로고
    • Molecular profiling predicts the existence of two functionally distinct classes of ovarian cancer stroma
    • doi:10.1155/2013/846387
    • Lili LN, Matyunina LV, Walkerm LD, Benigno BB, McDonald JF. Molecular profiling predicts the existence of two functionally distinct classes of ovarian cancer stroma. Biomed Res Int (2013) 2013:846387. doi:10.1155/2013/846387
    • (2013) Biomed Res Int , vol.2013 , pp. 846387
    • Lili, L.N.1    Matyunina, L.V.2    Walkerm, L.D.3    Benigno, B.B.4    McDonald, J.F.5
  • 133
    • 84874821284 scopus 로고    scopus 로고
    • New strategies in the treatment of ovarian cancer: current clinical perspectives and future potential
    • doi:10.1158/1078-0432.CCR-12-2243
    • Banerjee S, Kaye SB. New strategies in the treatment of ovarian cancer: current clinical perspectives and future potential. Clin Cancer Res (2013) 19:961-8. doi:10.1158/1078-0432.CCR-12-2243
    • (2013) Clin Cancer Res , vol.19 , pp. 961-968
    • Banerjee, S.1    Kaye, S.B.2
  • 134
    • 84884216639 scopus 로고    scopus 로고
    • Targeting tyrosine-kinases in ovarian cancer
    • doi:10.1517/13543784.2013.816282
    • Morotti M, Becker CM, Menada MV, Ferrero S. Targeting tyrosine-kinases in ovarian cancer. Expert Opin Investig Drugs (2013) 22:1265-79. doi:10.1517/13543784.2013.816282
    • (2013) Expert Opin Investig Drugs , vol.22 , pp. 1265-1279
    • Morotti, M.1    Becker, C.M.2    Menada, M.V.3    Ferrero, S.4
  • 135
    • 82255169379 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model
    • doi:10.1371/journal.pone.0028077
    • McCann CK, Growdon WB, Kulkarni-Datar K, Curley MD, Friel AM, Proctor JL, et al. Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model. PLoS One (2011) 6:e28077. doi:10.1371/journal.pone.0028077
    • (2011) PLoS One , vol.6
    • McCann, C.K.1    Growdon, W.B.2    Kulkarni-Datar, K.3    Curley, M.D.4    Friel, A.M.5    Proctor, J.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.