The expression of CCAAT/enhancer binding protein (C/EBP) in the human ovary in vivo: Specific increase in C/EBPβ during epithelial tumour progression

British Journal of Cancer

Volumn 79, Issue 7-8, 1999, Pages 1240-1248

  Sundfeldt, K ^a   Ivarsson, K ^a   Carlsson, M ^a   Enerback S ^a   Janson, P O ^a   Brannstrom M ^a   Hedin, L ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

C EBP; Ovarian surface epithelial cells; Transcription factors; Tumour formation

Indexed keywords

DNA BINDING PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CELL NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; ENHANCER REGION; EPITHELIUM TUMOR; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; OVARY; OVARY TUMOR; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TUMOR GROWTH; WESTERN BLOTTING;

ADENOCARCINOMA; ADENOFIBROMA; ADENOMA; BLOTTING, WESTERN; CCAAT-ENHANCER-BINDING PROTEINS; CYSTADENOCARCINOMA, SEROUS; DISEASE PROGRESSION; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM PROTEINS; NUCLEAR PROTEINS; OVARIAN NEOPLASMS; OVARY;

EID: 0033023190     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690199     Document Type: Article

References (40)

1. Akira S, Isshiki H, Sugita T, Tanabe O, Kinoshita S, Nishio Y, Nakajima T, Hirano T and Kishimoto T (1990) A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J 9: 1897-1906
2. Akira S and Kishimoto T (1992) IL-6 and NF-IL6 in acute-phase response and viral infection. Immunol Rev 127: 25-50
3. Altman DG (1991) Practical Statistics for Medical Research. Chapman and Hall: London
4. Aman P, Ron D, Mandahl N, Fioretos T, Heim S, Arheden K, Willën H, Rydholm A and Mitelman F (1992) Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas With t(12;16)(q13;p11). Gene Chrom Cancer 5: 278-285
5. Batchvarova N, Wang X-Z and Ron D (1995) Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd 153). EMBO J 14: 4654-4661
6. Cao Z, Umek RM and McKnight SL (1991) Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev 5: 1538-1552
7. Chandrasekaran C and Gordon JI (1993) Cell lineage-specific and differentiation-dependent patterns of CCAAT/enhancer binding protein α expression in the gut epithelium of normal and transgenic mice. Proc Natl Acad Sci USA 90: 8871-8875
8. Chen PL, Riley DJ, Chen-Kiang S and Lee WH (1996) Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proc Natl Acad Sci USA 93: 465-469
9. Descombes P and Schibler U (1991) A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67: 569-579
10. Dodson MK, Cliby WA, Xu HJ, DeLacey KA, Hu SX, Keeney GL, Li J, Podratz KC. Jenkins RB and Benedict WF (1994) Evidence of functional RB protein in epithelial ovarian carcinomas despite loss of heterozygosity at the RB locus. Cancer Res 54: 610-603
11. Ghosh S and Baltimore D (1990) Activation in vitro of NF Kappa B by phosphorylation of its inhibitor I kappa B. Nature 344: 678-682
12. Hamilton TC (1992) Ovarian Cancer, part 1: Biology. In Curr Prob Cancer 16; 1-57
13. Ivarsson KU, Runesson EB, Haeger M, Sundfeldt K, Hedin LF, Janson PO and Brännström M (1999) The chemotactic cytokine interleukin-8 (IL-8) a cyst fluid marker for malignant human epithelial ovarian cancer. Gynecol Oncol (in press)
14. Li F, Rosenberg E, Smith CI, Notarfrancesco K, Reisher SR, Shuman H and Feinstein SI (1995) Correlation of expression of transcription factor C/EBP-α and surfactant protein genes in lung cells. Am J Physiol 269: L241-L247
15. Lin F-T, MacDougald OA, Diehl AM and Lane MD (1993) A 30-kDa alternative translation product of the CCAAT/enhancer binding protein α message: transcriptional activator lacking antimitotic activity. Proc Natl Acad Sci USA 90: 9606-9610
16. Matsusaka T, Fujikawa K, Nishio Y, Mukaida N, Matsashima K, Kishimoto T and Akira S (1993) Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci USA 90: 10193-10197
17. McKnight SL (1991) C/EBP: A transcription factor that promotes terminal cell differentiation in a wide spectrum of tissues. In Origins of Human Cancer: a Comprehensive Review, Brugge J, Curran T, Harlow E and McCormick F (eds) pp. 345-352. Cold Spring Harbor Laboratory Press: Cold Spring Harbor
18. Metz E and Ziff E (1991) cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to translocate to the nucleus and induce c-fos transcription. Genes Dev 5: 1754-1766
19. Naylor MS, Stamp GW, Foulkes WD, Eccles D and Balkwill FR (1993) Tumour necrosis factor and its receptors in human ovarian cancer. Potential role in disease progression. J Clin Invest 91: 2194-2206
20. Park EA, Gurney AL, Nizielski SE, Hakimi P, Cao Z, Moorman A and Hanson RW (1993) Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP). J Biol Chem 268: 613-609
21. Piontkewitz Y, Enerbäck S and Hedin L (1993) Expression and hormonal regulation of the CCAAT enhancer binding protein-α during differentiation of rat ovarian follicles. Endocrinology 133: 2327-2333
22. Poli V, Mancini FP and Cortese R (1990) IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell 63: 643-653
23. Rana B, Xie Y, Mischoulon D, Bucher NL and Farmer SR (1995) The DNA binding activity of C/EBP transcription factor is regulated in the G1 phase of the hepatocyte cell cycle. J Biol Chem 270: 18123-18132
24. Raught B, Liao WS-L and Rosen JM (1995) Developmentally and hormonally regulated CCAAT/enhancer-binding protein isoforms influence β-casein gene expression. Mol Endocrinology 9: 1223-1232
25. Ron D and Habener JF (1992) CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 6: 439-453
26. Samuelsson L, Strömberg K, Vikman K, Bjursell G and Enerbäck S (1991) The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development. EMBO J 10: 3787-3793
27. Scott LM, Civin CI, Rorth P and Friedman AD (1992) A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood 80: 1725-1735
28. Silverberg E (1984) Cancer Statistics. CA Cancer J Clin 34: 7-23
29. Takasaki Y, Deng JS and Tan EM (1981) A nuclear antigen associated with cell proliferation and blast transformation. J Exp Med 154: 1899-1909
30. Tanaka T, Akira S, Yoshida K, Umemoto M, Yoneda Y, Shirafuji N, Fujiwara H, Suematsu S, Yoshida N and Kishimoto T (1995) Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumour cytotoxicity by macrophages. Cell 80: 353-361
31. Timchenko NA, Wilde M, Nakanishi M, Smith JR and Darlington GJ (1996) CCAAT/enhancer-binding protein alpha (C/EBP-α) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SD1-1) protein. Genes Dev 10: 804-815
32. Umek RM, Friedman AD and McKnight SL (1991) CCAAT-enhancer binding protein: a component of differentiation switch. Science 251: 288-292
33. Vinson CR, Hai T and Boyd SM (1993) Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: prediction and rational design. Genes Dev 7: 1047-1058
34. Watkins PJ, Condresay JP, Huber BE, Jacobs SJ and Adams DJ (1996) Impaired proliferation and tumorigenicity induced by CCAAT/ enhancer binding protein. Cancer Res 56: 1063-1067
35. Watson JM, Berek JS and Martinez-Maza O (1993) Growth inhibition of ovarian cancer cells induced by antisense IL-6 oligonucleotides. Gynecol Oncol 49: 8-15
36. Wegner M, Cao Z and Rosenfeld MG (1992) Calcium-regulated phosphorylation within the leucin zipper of C/EBP. Science 256: 370-373
37. Wu S, Boyer CM, Whitaker RS, Berchuck A, Wiener JR, Weinberg JB and Bast RC (1993) Tumour necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumour cell proliferation and tumour necrosis factor alpha expression. Cancer Res 53: 1939-1944
38. Xu L-X, Sui Y-F, Wang W-L, Liu Y-F and Gu J-R (1994) Immunohistochemical demonstration of CCAAT/Enhancer Binding Protein (C/EBP) in human liver tissues of various origin. Chin Med J 107: 596-599
39. Yin M, Yang SQ, Lin HZ, Lane MD, Chatterjee S and Diehl AM (1996) Tumour Necrosis Factor α promotes nuclear localization of cytokine-inducible CCAAT/Enhancer Binding Protein isoform in hepatocytes. J Biol Chem 271: 17974-17978
40. Zahnow CA, Younes P, Laucirica R and Rosen JM (1997) Overexpression of C/EBP-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer. JNCI 89: 1887-1891