HOXA7 in epithelial ovarian cancer: Interrelationships between differentiation and clinical features

Reproductive Sciences

Volumn 14, Issue 6, 2007, Pages 605-614

  Ota, Takayo ^a   Blake Gilks, C ^a   Longacre, Teri ^b   Leung, Peter C K ^a   Auersperg, Nelly ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Disease specific survival; HOXA7; Metaplasia; Ovarian cancer; Ovary

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HOXA7; UNCLASSIFIED DRUG; UVOMORULIN; CADHERIN; HOMEODOMAIN PROTEIN; HOXA7 PROTEIN, HUMAN; TUMOR MARKER;

ARTICLE; CANCER GROWTH; CANCER SURVIVAL; CLINICAL FEATURE; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; OVARY CANCER; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; ADENOCARCINOMA; CANCER STAGING; CELL DIFFERENTIATION; CELL NUCLEUS; CHEMISTRY; CLUSTER ANALYSIS; COLLOID CARCINOMA; CYSTADENOCARCINOMA; ENDOMETRIOID CARCINOMA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; KAPLAN MEIER METHOD; METAPLASIA; METHODOLOGY; MORTALITY; OVARY TUMOR; PATHOLOGY; STROMA CELL; TISSUE MICROARRAY;

ADENOCARCINOMA, CLEAR CELL; ADENOCARCINOMA, MUCINOUS; CADHERINS; CARCINOMA, ENDOMETRIOID; CELL DIFFERENTIATION; CELL NUCLEUS; CLUSTER ANALYSIS; CYSTADENOCARCINOMA, SEROUS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIERS ESTIMATE; METAPLASIA; NEOPLASM STAGING; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OVARIAN NEOPLASMS; PROGNOSIS; STROMAL CELLS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 38449107286     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719107307781     Document Type: Article

References (24)

1. Centers for Diseases Control and Prevention. 2004 / 2005. http://www.cdc.gov.
2. Bast RC Jr, Badgwell D., Lu Z., et al. New tumor markers: CA125 and beyond. Int J Gynecol Cancer. 2005 ; 15 (suppl 3). 274-281.
3. Veraksa A., Del Campo M, McGinnis W. Developmental patterning genes and their conserved functions: from model organisms to humans. Mol Genet Metab. 2000 ; 69: 85-100.
4. Del Bene F., Wittbrodt J. Cell cycle control by homeobox genes in development and disease. Semin Cell Dev Biol. 2005 ; 16: 449-460.
5. Taylor HS, Vanden Heuvel GB, Igarashi P. A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes. Biol Reprod. 1997 ; 57: 1338-1345.
6. Naora H., Montz FJ, Chai CY, Roden RB Aberrant expression of homeobox gene HOXA7 is associated with Mullerian-like differentiation of epithelial ovarian tumors and the generation of a specific autologous antibody response. Proc Natl Acad Sci U S A. 2001 ; 98: 15209-15214.
7. Pando SM, Taylor HS Homeobox gene expression in ovarian cancer. Cancer Treat Res. 2002 ; 107: 231-245.
8. Cheng W., Liu J., Yoshida H., Rosen D., Naora H. Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Nat Med. 2005 ; 11: 531-537.
9. Ota T., Choi KB, Gilks CB, Leung PC, Auersperg N. Cell type- and stage-specific changes in HOXA7 protein expression in human ovarian folliculogenesis: possible role of GDF-9. Differentiation. 2006 ; 74: 1-10.
10. Gilks CB, Vanderhyden BC, Zhu S., van de Rijn M., Longacre TA Distinction between serous tumors of low malignant potential and serous carcinomas based on global mRNA expression profiling. Gynecol Oncol. 2005 ; 96: 684-694.
11. Tavassoli FA, Devilee P, eds. World Health Organization Classification of Tumours: Pathology and Genetics, Tumours of the Breast and Female Genital Organs. Lyon, France: IARC Press ; 2003.
12. Shimizu Y., Kamoi S., Amada S., et al. Toward the development of a universal grading system for ovarian epithelial carcinoma. I. Prognostic significance of histopathologic features-problems involved in the architectural grading system. Gynecol Oncol. 1998 ; 70 (1). 2-12.
13. Feeley KM, Wells M. Precursor lesions of ovarian epithelial malignancy. Histopathology. 2001 ; 38: 87-95.
14. Auersperg N., Pan J., Grove BD, et al. E-cadherin induces mesenchymal-epithelial transition in human ovarian surface epithelium. Proc Natl Acad Sci U S A. 1999 ; 96: 6249-6254.
15. Maines-Bandiera SL, Auersperg N. Increased E-cadherin expression in ovarian surface epithelium: an early step in metaplasia and dysplasia? Int J Gynecol Pathol. 1997 ; 16: 250-255.
16. Kosaka Y., Akimoto Y., Yokozawa K., Obinata A., Hirano H. Localization of HB9 homeodomain protein and characterization of its nuclear localization signal during chick embryonic skin development. Histochem Cell Biol. 2004 ; 122: 237-247.
17. Soubry A., van Hengel J., Parthoens E., et al. Expression and nuclear location of the transcriptional repressor Kaiso is regulated by the tumor microenvironment. Cancer Res. 2005 ; 65: 2224-2233.
18. Kirito K., Fox N., Kaushansky K. Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism by which the hormone favorably affects hematopoietic stem cells. Mol Cell Biol. 2004 ; 24: 6751-6762.
19. Komuves LG, Shen WF, Kwong A., et al. Changes in HOXB6 homeodomain protein structure and localization during human epidermal development and differentiation. Dev Dyn. 2000 ; 218: 636-647.
20. Le Page C., Koumakpayi IH, Alam-Fahmy M., Mes-Masson AM, Saad F. Expression and localization of Akt-1, Akt-2 and Akt-3 correlate with clinical outcome of prostate cancer patients. Br J Cancer. 2006 ; 94: 1906-1912.
21. Shah A., Swain WA, Richardson D., et al. Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer. Clin Cancer Res. 2005 ; 11: 2930-2936.
22. Uegaki K., Kanamori Y., Kigawa J., et al. PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma. Oncol Rep. 2005 ; 14: 389-392.
23. Schulze F., Chowdhury K., Zimmer A., Drescher U., Gruss P. The murine homeo box gene product, Hox 1.1 protein, is growth-controlled and associated with chromatin. Differentiation. 1987 ; 36: 130-137.
24. Yamashita T., Tazawa S., Yawei Z., et al. Suppression of invasive characteristics by antisense introduction of overexpressed HOX genes in ovarian cancer cells. Int J Oncol. 2006 ; 28: 931-938.