Cytoplasmic and stromal expression of laminin γ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type

Oncology Reports

Volumn 24, Issue 6, 2010, Pages 1569-1576

  Okuma, Emi ^a   Ohishi, Yoshihiro ^a,b   Oda, Yoshinao ^a   Aishima, Shinichi ^a   Kurihara, Shuichi ^a   Nishimura, Izumi ^a   Yasunaga, Masafumi ^a   Kobayashi, Hiroaki ^a   Wake, Norio ^a   Tsuneyoshi, Masazumi ^a  

^a KYUSHU UNIVERSITY HOSPITAL   (Japan)

^b KYUSHU UNIVERSITY BEPPU HOSPITAL   (Japan)

Author keywords

Infiltrative invasion; Laminin 2 chain; Mural nodule; Ovarian mucinous neoplasms of gastro intestinal type

Indexed keywords

LAMININ; LAMININ GAMMA2; UNCLASSIFIED DRUG;

ARTICLE; BASEMENT MEMBRANE; CANCER INFILTRATION; CANCER INVASION; CYTOPLASM; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; MORPHOLOGY; OVARIAN MUCINOUS NEOPLASM OF GASTROINTESTINAL TYPE; OVARY TUMOR; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ADENOCARCINOMA, MUCINOUS; COHORT STUDIES; CYTOPLASM; DISEASE PROGRESSION; FEMALE; GASTROINTESTINAL NEOPLASMS; HUMANS; LAMININ; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; NEOPLASM STAGING; OVARIAN NEOPLASMS; PROGNOSIS; STROMAL CELLS; TUMOR MARKERS, BIOLOGICAL;

EID: 78649402489     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00001019     Document Type: Article

References (36)

1. Siedman JD, Russell P and Kurman RJ: Surface epithelial tumor of the ovary. In: Blaustein's Pathology of the Female Genital Tract. 5th edition, Kurman RJ (eds). Springer-Verlag, New York, pp810-811, 2002
2. Lee KR and Scully RE: Mucinous tumors of the ovary: a clinicopathologic study of 196 borderline tumors (of intestinal type) and carcinomas, including an evaluation of 11 cases with 'pseudomyxoma peritonei'. Am J Surg Pathol 24: 1447-1464, 2000.
3. Puls LE, Powell DE, DePriest PD, et al: Transition from benign to malignant epithelium in mucinous and serous ovarian cystadenocarcinoma. Gynecol Oncol 47: 53-57, 1992.
4. Riopel MA, Ronnett BM and Kurman RJ: Evaluation of diagnostic criteria and behavior of ovarian intestinal-type mucinous tumors: atypical proliferative (borderline) tumors and intraepithelial, microinvasive, invasive, and metastatic carcinomas. Am J Surg Pathol 23: 617-635, 1999.
5. Hoerl HD and Hart WR: Primary ovarian mucinous cystadenocarcinomas: a clinicopathologic study of 49 cases with long-term follow-up. Am J Surg Pathol 22: 1449-1462, 1998.
6. Rodriguez IM and Prat J: Mucinous tumors of the ovary: a clinicopathologic analysis of 75 borderline tumors (of intestinal type) and carcinomas. Am J Surg Pathol 26: 139-152, 2002.
7. Ronnett BM, Kajdacsy-Balla A, Gilks CB, et al: Mucinous borderline ovarian tumors: points of general agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behavior. Hum Pathol 35: 949-960, 2004.
8. Hart WR: Mucinous tumors of the ovary: a review. Int J Gynecol Pathol 24: 4-25, 1994.
9. Baergen RN and Rutgers JL: Mural nodules in common epithelial tumors of the ovary. Int J Gynecol Pathol 13: 62-72, 1994.
10. Chan YF, Ho HC, Yau SM, et al: Ovarian mucinous tumor with mural nodules of anaplastic carcinoma. Gynecol Oncol 35: 112-119, 1989.
11. Hayman JA and Ostor AG: Ovarian mucinous tumour with a focus of anaplastic carcinoma: a case report. Pathology 17: 591-593, 1985.
12. Nakamura E, Shimizu M, Mikami Y, et al: Ovarian mucinous cystadenocarcinoma with malignant mural nodules. Pathol Int 48: 645-648, 1998. (Pubitemid 28399637)
13. Nichols GE, Mills SE, Ulbright TM, et al: Spindle cell mural nodules in cystic ovarian mucinous tumors. A clinicopathologic and immunohistochemical study of five cases. Am J Surg Pathol 15: 1055-1062, 1991.
14. Beck K, Hunter I and Engel J: Structure and function of laminin: anatomy of a multidomain glycoprotein. FASEB J 4: 148-160, 1990.
15. Mizushima H, Koshikawa N, Moriyama K, et al: Wide distribution of laminin-5 gamma 2 chain in basement membranes of various human tissues. Horm Res 50 (Suppl 2): 7-14, 1998.
16. Pyke C, Romer J, Kallunki P, et al: The gamma 2 chain of kalinin/laminin 5 is preferentially expressed in invading malignant cells in human cancers. Am J Surg Pathol 145: 782-791, 1994.
17. Pyke C, Salo S, Ralfkiaer E, et al: Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas. Cancer Res 55: 4132-4139, 1995.
18. Koshikawa N, Moriyama K, Takamura H, et al: Overexpression of laminin gamma 2 chain monomer in invading gastric carcinoma cells. Cancer Res 59: 5596-5601, 1999.
19. Aishima S, Matsuura S, Terashi T, et al: Aberrant expression of laminin gamma 2 chain and its prognostic significance in intrahepatic cholangiocarcinoma according to growth morphology. Mod Pathol 17: 938-945, 2004.
20. Moriya Y, Niki T, Yamada T, et al: Increased expression of laminin-5 and its prognostic significance in lung adenocarcinomas of small size. An immunohistochemical analysis of 102 cases. Cancer 91: 1129-1141, 2001.
21. Soini Y, Maatta M, Salo S, et al: Expression of the laminin gamma 2 chain in pancreatic adenocarcinoma. J Pathol 180: 290-294, 1996.
22. Patel V, Aldridge K, Ensley JF, et al: Laminin-gamma2 overexpression in head-and-neck squamous cell carcinoma. Int J Cancer 99: 583-588, 2002.
23. Yamamoto H, Itoh F, Iku S, et al: Expression of the gamma (2) chain of laminin-5 at the invasive front is associated with recurrence and poor prognosis in human esophageal squamous cell carcinoma. Clin Cancer Res 7: 896-900, 2001.
24. Skyldberg B, Salo S, Eriksson E, et al: Laminin-5 as a marker of invasiveness in cervical lesions. J Natl Cancer Inst 91: 1882-1887, 1999.
25. Seidman JD, Kurman RJ and Ronnett BM: Primary and metastatic mucinsou adenocarcinomas in the ovaries: Incidence in routine practice with a new approach to improve intraoperative diagnosis. Am J Surg Pathol 27: 985-993, 2003.
26. Yemelyanova AV, Vang R and Judson K, et al: Distinction of primary and metastatic mucinous tumors involving the ovary: analysis of size and laterality data by primary site with reevaluation of an algorithm for tumor classification. Am J Surg Pathol 32: 128-138, 2008.
27. Niessen CM, Hogervorst F, Jaspars LH, et al: The alpha 6 beta 4 integrin is a receptor for both laminin and kalinin. Exp Cell Res 211: 360-367, 1994.
28. Schenk S, Hintermann E, Bilban M, et al: Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution. J Cell Biol 161: 197-209, 2003.
29. Amano S, Scott IC, Takahara K, et al: Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain. J Biol Chem 275: 22728-22735, 2000.
30. Veitch DP, Nokelainen P, McGowan KA, et al: Mammalian tolloid metalloproteinase, and not matrix metalloprotease 2 or membrane type 1 metalloprotease, processes laminin-5 in keratinocytes and skin. J Biol Chem 278: 15661-15668, 2003.
31. Flug M and Kopf-Maier P: The basement membrane and its involvement in carcinoma cell invasion. Acta Anat 152: 69-84, 1995.
32. Lohi J: Laminin-5 in the progression of carcinomas. Int J Cancer 94: 763-767, 2001.
33. Shinto E, Mochizuki H, Ueno H, et al: A novel classification of tumour budding in colorectal cancer based on the presence of cytoplasmic pseudo-fragments around budding foci. Histopathology 47: 25-31, 2005.
34. Kato N, Sasou S, Teshima S, et al: Overexpression of laminin-5 gamma 2 chain in clear cell carcinoma of the ovary. Virchows Arch 450: 273-278, 2007.
35. Katayama M, Sanzen N, Funakoshi A, et al: Laminin gamma 2- chain fragment in the circulation: a prognostic indicator of epithelial tumor invasion. Cancer Res 63: 222-229, 2003.
36. Aumailley M, El Khal A, Knoss N, et al: Laminin 5 processing and its integration into the ECM. Matrix Biol 22: 49-54, 2003.