Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression

BMC Cancer

Volumn 9, Issue , 2009, Pages

  Tuhkanen, Hanna ^a,b   Soini, Ylermi ^a,b   Kosma, Veli Matti ^a,b   Anttila, Maarit ^a,b   Sironen, Reijo ^a,b   Hämäläinen, Kirsi ^b   Kukkonen, Laura ^a,b   Virtanen, Ismo ^c   Mannermaa, Arto ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SNAIL 1; UNCLASSIFIED DRUG; NUCLEAR PROTEIN; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

ADULT; AGED; ARTICLE; BENIGN TUMOR; CARCINOGENESIS; CELL NUCLEUS; CELL SURFACE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; OVARY CARCINOMA; OVARY TUMOR; PERITONEUM CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STROMA CELL; TUMOR GROWTH; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; ONCOGENESIS AND MALIGNANT TRANSFORMATION; PATHOLOGY;

ADULT; AGED; AGED, 80 AND OVER; CELLS, CULTURED; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MIDDLE AGED; NEOPLASTIC PROCESSES; NUCLEAR PROTEINS; OVARIAN NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 70049095113     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-9-289     Document Type: Article

References (34)

1. Parkin DM Bray F Ferlay J Pisani P Global cancer statistics, 2002 CA Cancer J Clin 2005, 55:74-108 10.3322/canjclin.55.2.74 15761078
2. Shih IM Kurman RJ Ovarian tumourigenesis: A proposed model based on morphological and molecular genetic analysis Am J Pathol 2007, 164:1511-1518
3. Bell DA Origins and molecular pathology of ovarian cancer Mod Pathol 2005, 18:S19-S32 10.1038/modpathol.3800306 15761464
4. Landen CN Birrer MJ Sood AK Early events in the pathogenesis of epithelial ovarian cancer J Clin Oncol 2008, 26:995-1005 10.1200/ JCO.2006.07.9970 18195328
5. Auersperg N Wong AS Choi KC Kang SK Leung PC Ovarian surface epithelium: biology, endocrinology, and pathology Endocr Rev 2001, 22:255-288 10.1210/er.22.2.255 11294827
6. Thiery JP Sleeman JP Complex networks orchestrate epithelial-mesenchymal transitions Nat Rev Mol Cell Biol 2006, 7:131-142 10.1038/nrm1835 16493418
7. Tuhkanen H Anttila M Kosma VM Heinonen S Juhola M Helisalmi S Kataja V Mannermaa A Frequent gene dosage alterations in stromal cells of epithelial ovarian carcinomas Int J Cancer 2006, 119:1345-1353 10.1002/ ijc.21785 16642473
8. De Wever O Pauwels P De Craene B Sabbah M Emami S Redeuilh G Gespach C Bracke M Berx G Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front Histochem Cell Biol 2008, 130:481-494 10.1007/s00418-008-0464-1 2522326 18648847
9. Ansieau S Bastid J Doreau A Morel AP Bouchet BP Thomas C Fauvet F Puisieux I Doglioni C Piccinin S Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence Cancer Cell 2008, 14:79-89 10.1016/j.ccr.2008.06.005 18598946
10. Peinado H Olmeda D Cano A Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype? Nat Rev Cancer 2007, 7:415-428 10.1038/nrc2131 17508028
11. Takkunen M Grenman R Hukkanen M Korhonen M Garcia de Herreros A Virtanen I Snail-dependent and -independent epithelial-mesenchymal transition in oral squamous carcinoma cells J Histochem Cytochem 2006, 54:1263-1275 10.1369/jhc.6A6958.2006 16899764
12. Vega S Morales AV Ocana OH Valdes F Fabregat I Nieto MA Snail blocks the cell cycle and confers resistance to cell death Genes Dev 2004, 18:1131-1143 10.1101/gad.294104 415638 15155580
13. Becker KF Rosivatz E Blechschmidt K Kremmer E Sarbia M Höfler H Analysis of the E-cadherin repressor snail in primary human cancers Cells Tissues Organs 2007, 185:204-212 10.1159/000101321 17587826
14. Franci C Takkunen M Dave N Alameda F Gomez S Rodriguez R Escriva M Montserrat-Sentis B Baro T Garrido M Expression of Snail protein in tumor-stroma interface Oncogene 2006, 25:5134-5144 16568079
15. Rosivatz E Becker KF Kremmer E Schott C Blechschmidt K Höfler H Sarbia M Expression and nuclear localization of Snail, an E-cadherin repressor, in adenocarcinomas of the upper gastrointestinal tract Virchows Arch 2006, 448:277-287 10.1007/s00428-005-0118-9 16328348
16. Blechschmidt K Sassen S Schmalfeldt B Schuster T Höfler H Becker KF The E-cadherin repressor Snail is associated with lower overall survival of ovarian cancer patients Br J Cancer 2008, 98:489-495 10.1038/ sj.bjc.6604115 18026186
17. Blechschmidt K Kremmer E Hollweck R Mylonas I Höfler H Kremer M Becker KF The E-cadherin repressor Snail plays a role in tumor progression of endometrioid adenocarcinomas Diagn Mol Pathol 2007, 16:222-228 10.1097/PDM.0b013e31806219ae 18043286
18. Zidar N Gale N Kojc N Volavsek M Cardesa A Alos L Höfler H Blechschmidt K Becker KF Cadherin-catenin complex and transcription factor Snail-1 in spindle cell carcinoma of the head and neck Virchows Arch 2008, 453:267-274 10.1007/s00428-008-0649-y 18712413
19. Franz M Spiegel K Umbreit C Richter P Codina-Canet C Berndt A Altendorf-Hofmann A Koscielny S Hyckel P Kosmehl H Expression of Snail is associated with myofibroblast phenotype development in oral squamous cell carcinoma Histochem Cell Biol 2009, 131:651-660 10.1007/ s00418-009-0559-3 19198871
20. Peinado H Moreno-Bueno G Hardisson D Perez-Gomez E Santos V Mendiola M de Diego JI Nistal M Quintanilla M Portillo F Lysyl oxidase-like 2 as a new poor prognostic marker of squamous cell carcinomas Cancer Res 2008, 68:4541-4550 10.1158/0008-5472.CAN-07-6345 18559498
21. Elloul S Silins I Trope CG Benshushan A Davidson B Reich R Expression of E-cadherin transcriptional regulators in ovarian carcinoma Virchows Arch 2006, 449:520-528 10.1007/s00428-006-0274-6 17024425
22. Sobin LH Wittekind Ch editors International Union Against Cancer (UICC). TNM Classification of Malignant Tumours New York: Wiley-Liss 6 2002:165-169
23. Tavassoli FA Devilee P editors World Health Organization Classification of Tumours. Tumours of the Breast and Female Genital Organs Lyon: IARC Press 2003:113-45
24. Soini Y Salo T Satta J Angiogenesis is involved in the pathogenesis of nonrheumatic aortic valve stenosis Hum Pathol 2003, 34:756-763 10.1016/ S0046-8177(03)00245-4 14506635
25. Chen X Halberg RB Burch RP Dove WF Intestinal adenomagenesis involves core molecular signatures of the epithelial-mesenchymal transition J Mol Histol 2008, 39:283-294 10.1007/s10735-008-9164-3 2544376 18327651
26. Blanco MJ Barrallo-Gimeno A Acloque H Reyes AE Tada M Allende ML Mayor R Nieto MA Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo Development 2007, 134:4073-4081 10.1242/dev.006858 17965052
27. Barrallo-Gimeno A Nieto MA The snail genes as inducers of cell movement and survival: Implications in development and cancer Development 2005, 132:3151-3161 10.1242/dev.01907 15983400
28. Liotta LA Kohn EC The microenvironment of the tumour-host interface Nature 2001, 411:375-379 10.1038/35077241 11357145
29. Petersen OW Nielsen HL Gudjonsson T Villadsen R Rank F Niebuhr E Bisell MJ Ronnov-Jessen L Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma Am J Pathol 2003, 162:391-402 1851146 12547698
30. Rowe RG Li XY Hu Y Saunders TL Virtanen I Garcia de Herreros A Becker KF Ingvarsen S Engelholm LH Bommer GT Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs J Cell Biol 2009, 184:399-408 10.1083/jcb.200810113 2646556 19188491
31. Kudo-Saito C Shirako H Takeuchi T Kawakami Y Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells Cancer Cell 2009, 15:195-206 10.1016/j.ccr.2009.01.023 19249678
32. Zeisberg EM Potenta S Xie L Zeisberg M Kalluri R Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts Cancer Res 2007, 67:10123-10128 10.1158/ 0008-5472.CAN-07-3127 17974953
33. Kokudo T Suzuki Y Yoshimatsu Y Yamazaki T Watanabe T Miyazono K Snail is required for TGFβ-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells J Cell Sci 2008, 121:3317-3324 10.1242/jcs.028282 18796538
34. Ramakrishnan S Subramanian IV Yokoyama Y Geller M Angiogenesis in normal and neoplastic ovaries Angiogenesis 2005, 8:169-182 10.1007/ s10456-005-9001-1 16211363