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Volumn 22, Issue 10, 2013, Pages 1265-1279

Targeting tyrosine-kinases in ovarian cancer

Author keywords

Angiogenesis; Ovarian cancer; Targeted therapy; Tyrosine kinase inhibitor; Tyrosine kinases

Indexed keywords

BEVACIZUMAB; BIOLOGICAL MARKER; CANERTINIB; CARBOPLATIN; CEDIRANIB; DASATINIB; DOCETAXEL; ERLOTINIB; GEFITINIB; GEMCITABINE; IMATINIB; LAPATINIB; NINTEDANIB; PACLITAXEL; PAZOPANIB; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB; TAMOXIFEN; TOPOTECAN; VANDETANIB; VASCULOTROPIN RECEPTOR; VATALANIB;

EID: 84884216639     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2013.816282     Document Type: Review
Times cited : (25)

References (97)
  • 2
    • 16244403039 scopus 로고    scopus 로고
    • Cancer incidence and mortality in Europe 2004
    • Boyle P, Ferlay J. Cancer incidence and mortality in Europe 2004. Ann Oncol 2005;16:481-8
    • (2005) Ann Oncol , vol.16 , pp. 481-488
    • Boyle, P.1    Ferlay, J.2
  • 3
    • 79959774261 scopus 로고    scopus 로고
    • Recent progress in the diagnosis and treatment of ovarian cancer
    • Jelovac D, Armstrong DK. Recent progress in the diagnosis and treatment of ovarian cancer. CA Cancer J Clin 2011;61:183-203
    • (2011) CA Cancer J Clin , vol.61 , pp. 183-203
    • Jelovac, D.1    Armstrong, D.K.2
  • 4
    • 64249135764 scopus 로고    scopus 로고
    • Novel agents on the horizon for cancer therapy
    • Ma WW, Adjei AA. Novel agents on the horizon for cancer therapy. CA Cancer J Clin 2009;59:111-37
    • (2009) CA Cancer J Clin , vol.59 , pp. 111-137
    • Ma, W.W.1    Adjei, A.A.2
  • 6
    • 84864587754 scopus 로고    scopus 로고
    • Perspective: Dynamics of receptor tyrosine kinase signaling complexes
    • Mayer BJ. Perspective: dynamics of receptor tyrosine kinase signaling complexes. FEBS Lett 2012;586:2575-9
    • (2012) FEBS Lett , Issue.586 , pp. 2575-2579
    • Mayer, B.J.1
  • 7
    • 0036769119 scopus 로고    scopus 로고
    • Regulation and targets of receptor tyrosine kinases
    • Pawson T. Regulation and targets of receptor tyrosine kinases. Eur J Cancer 2002;38:S3-S10
    • (2002) Eur J Cancer , vol.38
    • Pawson, T.1
  • 8
    • 3042634240 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors in cancer therapy
    • Madhusudan S, Ganesan TS. Tyrosine kinase inhibitors in cancer therapy. Clin Biochem 2004;37:618-35
    • (2004) Clin Biochem , vol.37 , pp. 618-635
    • Madhusudan, S.1    Ganesan, T.S.2
  • 9
    • 0035901570 scopus 로고    scopus 로고
    • Epidermal growth factor receptor signaling
    • Bogdan S, Klambt C. Epidermal growth factor receptor signaling. Curr Biol 2001;11:292-5
    • (2001) Curr Biol , vol.11 , pp. 292-295
    • Bogdan, S.1    Klambt, C.2
  • 10
    • 0037032835 scopus 로고    scopus 로고
    • The protein kinase complement of the human genome
    • Manning G, Whyte DB, Martinez R, et al. The protein kinase complement of the human genome. Science 2002;298:1912-34
    • (2002) Science , vol.298 , pp. 1912-1934
    • Manning, G.1    Whyte, D.B.2    Martinez, R.3
  • 11
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS. Tumor angiogenesis. N Engl J Med 2008;358:2039-49
    • (2008) N Engl J Med , vol.358 , pp. 2039-2049
    • Kerbel, R.S.1
  • 12
    • 84859156536 scopus 로고    scopus 로고
    • Targeting angiogenesis in ovarian cancer
    • Schmitt J, Matei D. Targeting angiogenesis in ovarian cancer. Cancer Treat Rev 2012;38:272-83
    • (2012) Cancer Treat Rev , vol.38 , pp. 272-283
    • Schmitt, J.1    Matei, D.2
  • 13
    • 27544479318 scopus 로고    scopus 로고
    • Role of tyrosine kinase inhibitors in cancer therapy
    • Arora A, Scholar EM. Role of tyrosine kinase inhibitors in cancer therapy. J Pharmacol Exp Ther 2005;315:971-9
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 971-979
    • Arora, A.1    Scholar, E.M.2
  • 14
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005;438:967-74
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 16
    • 79954431774 scopus 로고    scopus 로고
    • The therapeutic potential of targeting the EGFR family in epithelial ovarian cancer
    • Sheng Q, Liu J. The therapeutic potential of targeting the EGFR family in epithelial ovarian cancer. Br J Cancer 2011;104:1241-5
    • (2011) Br J Cancer , Issue.104 , pp. 1241-1245
    • Sheng, Q.1    Liu, J.2
  • 18
    • 84873619713 scopus 로고    scopus 로고
    • Targeted anti-vascular therapies for ovarian cancer: Current evidence
    • Hall M, Gourley C, McNeish I, et al. Targeted anti-vascular therapies for ovarian cancer: current evidence. Br J Cancer 2013;108:250-8
    • (2013) Br J Cancer , vol.108 , pp. 250-258
    • Hall, M.1    Gourley, C.2    McNeish, I.3
  • 19
    • 84862307591 scopus 로고    scopus 로고
    • Significance of vascular endothelial growth factor in growth and peritoneal dissemination of ovarian cancer
    • Masoumi Moghaddam S, Amini A, Morris DL, et al. Significance of vascular endothelial growth factor in growth and peritoneal dissemination of ovarian cancer. Cancer Metastasis Rev 2012;31:143-62
    • (2012) Cancer Metastasis Rev , vol.31 , pp. 143-162
    • Masoumi Moghaddam, S.1    Amini, A.2    Morris, D.L.3
  • 20
    • 1842850792 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients
    • Kassim SK, El-Salahy EM, Fayed ST, et al. Vascular endothelial growth factor and interleukin-8 are associated with poor prognosis in epithelial ovarian cancer patients. Clin Biochem 2004;37:363-9
    • (2004) Clin Biochem , vol.37 , pp. 363-369
    • Kassim, S.K.1    El-Salahy, E.M.2    Fayed, S.T.3
  • 21
    • 3242658330 scopus 로고    scopus 로고
    • Correlation of serum VEGF levels with clinical stage, therapy effi cacy, tumor metastasis and patient survival in ovarian cancer
    • Li L, Wang L, Zhang W, et al. Correlation of serum VEGF levels with clinical stage, therapy effi cacy, tumor metastasis and patient survival in ovarian cancer. Anticancer Res 2004;24:1973-9
    • (2004) Anticancer Res , vol.24 , pp. 1973-1979
    • Li, L.1    Wang, L.2    Zhang, W.3
  • 22
    • 1842582507 scopus 로고    scopus 로고
    • Expression of platelet-derived growth factor and activated receptor in clinical specimens of epithelial ovarian cancer and ovarian carcinoma cell lines
    • Apte SM, Bucana CD, Killion J, et al. Expression of platelet-derived growth factor and activated receptor in clinical specimens of epithelial ovarian cancer and ovarian carcinoma cell lines. Gynecol Oncol 2004;93:78-86
    • (2004) Gynecol Oncol , vol.93 , pp. 78-86
    • Apte, S.M.1    Bucana, C.D.2    Killion, J.3
  • 23
    • 0027365546 scopus 로고
    • Expression and prognostic significance of platelet-derived growth factor and its receptors in epithelial ovarian neoplasms
    • Henriksen R, Funa K, Wilander E, et al. Expression and prognostic significance of platelet-derived growth factor and its receptors in epithelial ovarian neoplasms. Cancer Res 1993;53:4550-4
    • (1993) Cancer Res , vol.53 , pp. 4550-4554
    • Henriksen, R.1    Funa, K.2    Wilander, E.3
  • 24
    • 84867311680 scopus 로고    scopus 로고
    • Immunohistochemical expression of platelet-derived growth factor receptors in ovarian cancer patients with long-term follow-up
    • Madsen CV, Dahl Steffensen K, Waldstrom M, et al. Immunohistochemical expression of platelet-derived growth factor receptors in ovarian cancer patients with long-term follow-up. Pathol Res Int 2012;2012:851432
    • (2012) Pathol Res Int , vol.2012 , pp. 851432
    • Madsen, C.V.1    Dahl Steffensen, K.2    Waldstrom, M.3
  • 25
    • 0035913613 scopus 로고    scopus 로고
    • Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells
    • Alper O Bergmann-Leitner ES, Bennett TA, et al. Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells. J Natl Cancer Inst 2001;93:1375-84
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1375-1384
    • Alper, O.1    Bergmann-Leitner, E.S.2    Bennett, T.A.3
  • 26
    • 78349312308 scopus 로고    scopus 로고
    • Immunohistochemical expression of epidermal growth factor receptor, E-cadherin, and matrix metalloproteinase-9 in ovarian epithelial cancer and relation to patient deaths
    • Alshenawy HA. Immunohistochemical expression of epidermal growth factor receptor, E-cadherin, and matrix metalloproteinase-9 in ovarian epithelial cancer and relation to patient deaths. Ann Diagn Pathol 2010;14:387-95
    • (2010) Ann Diagn Pathol , Issue.14 , pp. 387-395
    • Alshenawy, H.A.1
  • 27
    • 0031056372 scopus 로고    scopus 로고
    • EGFR and steroid receptors in ovarian carcinoma: Comparison with prognostic parameters and outcome of patients
    • Fischer-Colbrie J, Witt A, Heinzl H, et al. EGFR and steroid receptors in ovarian carcinoma: comparison with prognostic parameters and outcome of patients. Anticancer Res 1997;17:613-19
    • (1997) Anticancer Res , vol.17 , pp. 613-619
    • Fischer-Colbrie, J.1    Witt, A.2    Heinzl, H.3
  • 28
    • 0035027576 scopus 로고    scopus 로고
    • The growth factors HER-2/neu and EGFR, their relationship, and their effects on the prognosis in early stage (FIGO I-II) epithelial ovarian carcinoma
    • Skirnisdottir I, Sorbe B, Seidal T. The growth factors HER-2/neu and EGFR, their relationship, and their effects on the prognosis in early stage (FIGO I-II) epithelial ovarian carcinoma. Int J Gynecol Cancer 2001;11:119-29
    • (2001) Int J Gynecol Cancer , vol.11 , pp. 119-129
    • Skirnisdottir, I.1    Sorbe, B.2    Seidal, T.3
  • 29
    • 27144527372 scopus 로고    scopus 로고
    • Phase i study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors
    • Moore M, Hirte HW, Siu L, et al. Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors. Ann Oncol 2005;16:1688-94
    • (2005) Ann Oncol , vol.16 , pp. 1688-1694
    • Moore, M.1    Hirte, H.W.2    Siu, L.3
  • 30
    • 31544460436 scopus 로고    scopus 로고
    • Phase i trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer
    • Siu LL, Awada A, Takimoto CH, et al. Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer. Clin Cancer Res 2006;12:144-51
    • (2006) Clin Cancer Res , vol.12 , pp. 144-151
    • Siu, L.L.1    Awada, A.2    Takimoto, C.H.3
  • 31
    • 79951988792 scopus 로고    scopus 로고
    • Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: A Gynecologic Oncology Group trial
    • Matei D, Sill MW, Lankes HA, et al. Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: a Gynecologic Oncology Group trial. J Clin Oncol 2011;29:69-75
    • (2011) J Clin Oncol , Issue.29 , pp. 69-75
    • Matei, D.1    Sill, M.W.2    Lankes, H.A.3
  • 32
    • 80052604394 scopus 로고    scopus 로고
    • Sorafenib as a third line therapy in patients with epithelial ovarian cancer or primary peritoneal cancer: A phase II study
    • Bodnar L, Górnas M, Szczylik C. Sorafenib as a third line therapy in patients with epithelial ovarian cancer or primary peritoneal cancer: a phase II study. Gynecol Oncol 2011;123:33-6
    • (2011) Gynecol Oncol , vol.123 , pp. 33-36
    • Bodnar, L.1    Górnas, M.2    Szczylik, C.3
  • 33
    • 77956799700 scopus 로고    scopus 로고
    • Sorafenib in combination with gemcitabine in recurrent epithelial ovarian cancer: A study of the Princess Margaret Hospital Phase II Consortium
    • Welch SA, Hirte HW, Elit L, et al. Sorafenib in combination with gemcitabine in recurrent epithelial ovarian cancer: a study of the Princess Margaret Hospital Phase II Consortium. Int J Gynecol Cancer 2010;20:787-93
    • (2010) Int J Gynecol Cancer , vol.20 , pp. 787-793
    • Welch, S.A.1    Hirte, H.W.2    Elit, L.3
  • 34
    • 81155148279 scopus 로고    scopus 로고
    • Sorafenib in combination with weekly topotecan in recurrent ovarian cancer, a phase I/II study of the Hoosier Oncology Group
    • Ramasubbaiah R, Perkins SM, Schilder J, et al. Sorafenib in combination with weekly topotecan in recurrent ovarian cancer, a phase I/II study of the Hoosier Oncology Group. Gynecol Oncol 2011;123:499-504
    • (2011) Gynecol Oncol , vol.123 , pp. 499-504
    • Ramasubbaiah, R.1    Perkins, S.M.2    Schilder, J.3
  • 35
    • 77951917301 scopus 로고    scopus 로고
    • Sorafenib in combination with carboplatin and paclitaxel as neoadjuvant chemotherapy in patients with advanced ovarian cancer
    • Peolcher M, Eckhardt M, Coch C, et al. Sorafenib in combination with carboplatin and paclitaxel as neoadjuvant chemotherapy in patients with advanced ovarian cancer. Cancer Chemother Pharmacol 2010;66:203-7
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 203-207
    • Peolcher, M.1    Eckhardt, M.2    Coch, C.3
  • 36
    • 49249113484 scopus 로고    scopus 로고
    • Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity
    • Azad NS, Posadas EM, Kwitkowski VE, et al.combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity. J Clin Oncol 2008;26:3709-14
    • (2008) J Clin Oncol , vol.26 , pp. 3709-3714
    • Azad, N.S.1    Posadas, E.M.2    Kwitkowski, V.E.3
  • 37
    • 84867882609 scopus 로고    scopus 로고
    • A phase II study of intermittent sorafenib with bevacizumab in bevacizumab-naive epithelial ovarian cancer (EOC) patients
    • abstract 5019
    • Kohn EC, Lee J, Annunziata CM, et al. A phase II study of intermittent sorafenib with bevacizumab in bevacizumab-na?ve epithelial ovarian cancer (EOC) patients. J Clin Oncol 2011;29:abstract 5019
    • (2011) J Clin Oncol , vol.29
    • Kohn, E.C.1    Lee, J.2    Annunziata, C.M.3
  • 38
    • 79251585977 scopus 로고    scopus 로고
    • A phase II study of sunitinib in patients with recurrent epithelial ovarian and primary peritoneal carcinoma: An NCIC Clinical Trials Group Study
    • Biagi JJ, Oza AM, Chalchal HI, et al. A phase II study of sunitinib in patients with recurrent epithelial ovarian and primary peritoneal carcinoma: an NCIC Clinical Trials Group Study. Ann Oncol 2011;22:335-40
    • (2011) Ann Oncol , vol.22 , pp. 335-340
    • Biagi, J.J.1    Oza, A.M.2    Chalchal, H.I.3
  • 39
    • 84865556743 scopus 로고    scopus 로고
    • A phase II trial (AGO 2.11) in platinum-resistant ovarian cancer: A randomized multicenter trial with sunitinib (SU11248) to evaluate dosage, schedule, tolerability, toxicity and effectiveness of a multitargeted receptor tyrosine kinase inhibitor monotherapy
    • Baumann KH, du Bois A, Meier W, et al. A phase II trial (AGO 2.11) in platinum-resistant ovarian cancer: a randomized multicenter trial with sunitinib (SU11248) to evaluate dosage, schedule, tolerability, toxicity and effectiveness of a multitargeted receptor tyrosine kinase inhibitor monotherapy. Ann Oncol 2012;23:2265-71
    • (2012) Ann Oncol , vol.23 , pp. 2265-2271
    • Baumann, K.H.1    Du Bois, A.2    Meier, W.3
  • 40
    • 84872869916 scopus 로고    scopus 로고
    • A phase II trial of Sunitinib malate in recurrent and refractory ovarian, fallopian tube and peritoneal carcinoma
    • Campos SM, Penson RT, Matulonis U, et al. A phase II trial of Sunitinib malate in recurrent and refractory ovarian, fallopian tube and peritoneal carcinoma. Gynecol Oncol 2013;128:215-20
    • (2013) Gynecol Oncol , vol.128 , pp. 215-220
    • Campos, S.M.1    Penson, R.T.2    Matulonis, U.3
  • 41
    • 77956649079 scopus 로고    scopus 로고
    • A phase II, open-label study evaluating pazopanib in patients with recurrent ovarian cancer
    • Friedlander M, Hancock KC, Rischin D, et al. A phase II, open-label study evaluating pazopanib in patients with recurrent ovarian cancer. Gynecol Oncol 2010;119:32-7
    • (2010) Gynecol Oncol , vol.119 , pp. 32-37
    • Friedlander, M.1    Hancock, K.C.2    Rischin, D.3
  • 42
    • 84884241079 scopus 로고    scopus 로고
    • Available from: http://www.clinicaltrials.gov/ct2/show/NCT00866697
  • 43
    • 80054688412 scopus 로고    scopus 로고
    • The PACOVAR-trial: A phase I/II study of pazopanib (GW786034) and cyclophosphamide in patients with platinum-resistant recurrent, pre-treated ovarian cancer
    • Eichbaum M, Mayer C, Eickhoff R, et al. The PACOVAR-trial: a phase I/II study of pazopanib (GW786034) and cyclophosphamide in patients with platinum-resistant recurrent, pre-treated ovarian cancer. BMC Cancer 2011;11:453
    • (2011) BMC Cancer , vol.11 , pp. 453
    • Eichbaum, M.1    Mayer, C.2    Eickhoff, R.3
  • 44
    • 58149219264 scopus 로고    scopus 로고
    • A phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: Final results of a PMH, Chicago and California consortia trial
    • abstract 5521
    • Hirte HW, Vidal L, Fleming GF, et al. A phase II study of cediranib (AZD2171) in recurrent or persistent ovarian, peritoneal or fallopian tube cancer: final results of a PMH, Chicago and California consortia trial. J Clin Oncol 2008;26:abstract 5521
    • (2008) J Clin Oncol , vol.26
    • Hirte, H.W.1    Vidal, L.2    Fleming, G.F.3
  • 45
    • 73949123481 scopus 로고    scopus 로고
    • Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer
    • Matulonis UA, Berlin S, Ivy P, et al. Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer. J Clin Oncol 2009;27:5601-6
    • (2009) J Clin Oncol , vol.27 , pp. 5601-5606
    • Matulonis, U.A.1    Berlin, S.2    Ivy, P.3
  • 46
    • 80053232638 scopus 로고    scopus 로고
    • Initial toxicity assessment of ICON6: A randomised trial of cediranib plus chemotherapy in platinum-sensitive relapsed ovarian cancer
    • Raja FA, Griffin CL, Qian W, et al. Initial toxicity assessment of ICON6: a randomised trial of cediranib plus chemotherapy in platinum-sensitive relapsed ovarian cancer. Br J Cancer 2011;105:884-9
    • (2011) Br J Cancer , vol.105 , pp. 884-889
    • Raja, F.A.1    Griffin, C.L.2    Qian, W.3
  • 47
    • 80053561888 scopus 로고    scopus 로고
    • Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer
    • Ledermann JA, Hackshaw A, Kaye S, et al. Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer. J Clin Oncol 2011;29:3798-804
    • (2011) J Clin Oncol , vol.29 , pp. 3798-3804
    • Ledermann, J.A.1    Hackshaw, A.2    Kaye, S.3
  • 48
    • 84884278794 scopus 로고    scopus 로고
    • Available from: http://clinicaltrials.gov/show/NCT01015118
  • 49
    • 84873743140 scopus 로고    scopus 로고
    • Phase i trial of PTK787/ZK222584 (PTK/ZK) in combination with carboplatin (C) and paclitaxel (T) in platinum-sensitive recurrent epithelial ovarian (EOC), fallopian tube (FT), or primary peritoneal (PPC) cancers
    • Juretzka MM, Aghajanian C, Hensley ML, et al. Phase I trial of PTK787/ZK222584 (PTK/ZK) in combination with carboplatin (C) and paclitaxel (T) in platinum-sensitive recurrent epithelial ovarian (EOC), fallopian tube (FT), or primary peritoneal (PPC) cancers. J Clin Oncol 2007;25:5564
    • (2007) J Clin Oncol , vol.25 , pp. 5564
    • Juretzka, M.M.1    Aghajanian, C.2    Hensley, M.L.3
  • 50
    • 34447320826 scopus 로고    scopus 로고
    • A phase IB, open label, safety and pharmacokinetic (PK) study of escalating doses of PTK787/ZK 222584 in combination with paclitaxel and carboplatin in patients (PTs) with stage IIC to IV epithelial ovarian cancer
    • Schroder W, Witteveen E, Abadie S, et al. A phase IB, open label, safety and pharmacokinetic (PK) study of escalating doses of PTK787/ZK 222584 in combination with paclitaxel and carboplatin in patients (PTs) with stage IIC to IV epithelial ovarian cancer. J Clin Oncol 2007;23:5042
    • (2007) J Clin Oncol , vol.23 , pp. 5042
    • Schroder, W.1    Witteveen, E.2    Abadie, S.3
  • 51
    • 74549205168 scopus 로고    scopus 로고
    • Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2
    • Annunziata CM, Walker AJ, Minasian L, et al. Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2. Clin Cancer Res 2010;16:664-72
    • (2010) Clin Cancer Res , vol.16 , pp. 664-672
    • Annunziata, C.M.1    Walker, A.J.2    Minasian, L.3
  • 52
    • 84884234894 scopus 로고    scopus 로고
    • Available from: http://clinicaltrials.gov/show/NCT00445549
  • 54
    • 28944439741 scopus 로고    scopus 로고
    • Efficacy and safety of erlotinib HCL, an epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: Results from a phase II multicenter study
    • Gordon AN, Finkler N, Edwards RP, et al. Efficacy and safety of erlotinib HCL, an epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: results from a phase II multicenter study. Int J Gynecol Cancer 2005;15:785-92
    • (2005) Int J Gynecol Cancer , vol.15 , pp. 785-792
    • Gordon, A.N.1    Finkler, N.2    Edwards, R.P.3
  • 55
    • 78149360639 scopus 로고    scopus 로고
    • Erlotinib added to carboplatin and paclitaxel as first-line treatment of ovarian cancer: A phase II study basedonsurgical reassessment
    • Blank SV, Christos P, Curtin JP, et al. Erlotinib added to carboplatin and paclitaxel as first-line treatment of ovarian cancer: a phase II study basedonsurgical reassessment. Gynecol Oncol 2010;119:451-6
    • (2010) Gynecol Oncol , vol.119 , pp. 451-456
    • Blank, S.V.1    Christos, P.2    Curtin, J.P.3
  • 56
    • 44349178606 scopus 로고    scopus 로고
    • A phase Ib trial of docetaxel, carboplatin and erlotinib in ovarian, fallopian tube and primary peritoneal cancers
    • Vasey PA, Gore M, Wilson R, et al. A phase Ib trial of docetaxel, carboplatin and erlotinib in ovarian, fallopian tube and primary peritoneal cancers. Br J Cancer 2008;98:1774-80
    • (2008) Br J Cancer , vol.98 , pp. 1774-1780
    • Vasey, P.A.1    Gore, M.2    Wilson, R.3
  • 57
    • 77955552371 scopus 로고    scopus 로고
    • A phase II study of erlotinib (OSI-774) given in combination with carboplatin in patients with recurrent epithelial ovarian cancer (NCIC CTG IND.149)
    • Hirte H, Oza A, Swenerton K, et al. A phase II study of erlotinib (OSI-774) given in combination with carboplatin in patients with recurrent epithelial ovarian cancer (NCIC CTG IND.149). Gynecol Oncol 2010;118:308-12
    • (2010) Gynecol Oncol , vol.118 , pp. 308-312
    • Hirte, H.1    Oza, A.2    Swenerton, K.3
  • 58
    • 45549099056 scopus 로고    scopus 로고
    • Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: A trial of the Chicago, PMH, and California Phase II Consortia
    • Nimeiri HS, Oza AM, Morgan RJ, et al. Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California Phase II Consortia. Gynecol Oncol 2008;110:49-55
    • (2008) Gynecol Oncol , vol.110 , pp. 49-55
    • Nimeiri, H.S.1    Oza, A.M.2    Morgan, R.J.3
  • 59
    • 78049477139 scopus 로고    scopus 로고
    • Overexpression of tumor vascular endothelial growth factor A may portend an increased likelihood of progression in a phase II trial of bevacizumab and erlotinib in resistant ovarian cancer
    • Chambers SK, Clouser MC, Baker AF, et al. Overexpression of tumor vascular endothelial growth factor A may portend an increased likelihood of progression in a phase II trial of bevacizumab and erlotinib in resistant ovarian cancer. Clin Cancer Res 2010;16:5320-8
    • (2010) Clin Cancer Res , vol.16 , pp. 5320-5328
    • Chambers, S.K.1    Clouser, M.C.2    Baker, A.F.3
  • 60
    • 84867062943 scopus 로고    scopus 로고
    • Randomized phase III study of erlotinib versus observation in patients with no evidence of disease progression after first-line platin-based chemotherapy for ovarian carcinoma: A GCIG and EORTC-GCG study [abstract]
    • Vergote I, Joly F, Katsaros D, et al. Randomized phase III study of erlotinib versus observation in patients with no evidence of disease progression after first-line platin-based chemotherapy for ovarian carcinoma: a GCIG and EORTC-GCG study [abstract]. J Clin Oncol 2012;30:LBA5000
    • (2012) J Clin Oncol , vol.30
    • Vergote, I.1    Joly, F.2    Katsaros, D.3
  • 61
    • 23044511620 scopus 로고    scopus 로고
    • Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: A Gynecologic Oncology Group Study
    • Schilder RJ, Sill MW, Chen X, et al. Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: a Gynecologic Oncology Group Study. Clin Cancer Res 2005;11:5539-48
    • (2005) Clin Cancer Res , vol.11 , pp. 5539-5548
    • Schilder, R.J.1    Sill, M.W.2    Chen, X.3
  • 62
    • 33947318253 scopus 로고    scopus 로고
    • Gefitinib in combination with tamoxifen in patients with ovarian cancer refractory or resistant to platinum-taxane based therapy - A phase II trial of the AGO Ovarian Cancer Study Group (AGOOVAR 2.6)
    • Wagner U, du Bois A, Pfisterer J, et al. Gefitinib in combination with tamoxifen in patients with ovarian cancer refractory or resistant to platinum-taxane based therapy-a phase II trial of the AGO Ovarian Cancer Study Group (AGOOVAR 2.6). Gynecol Oncol 2007;105:132-7
    • (2007) Gynecol Oncol , vol.105 , pp. 132-137
    • Wagner, U.1    Du Bois, A.2    Pfisterer, J.3
  • 63
    • 33947523019 scopus 로고    scopus 로고
    • A phase II and pharmacodynamic study of gefitinib in patients with refractory or recurrent epithelial ovarian cancer
    • Posadas EM, Liel MS, Kwitkowski V, et al. A phase II and pharmacodynamic study of gefitinib in patients with refractory or recurrent epithelial ovarian cancer. Cancer 2007;109:1323-30
    • (2007) Cancer , vol.109 , pp. 1323-1330
    • Posadas, E.M.1    Liel, M.S.2    Kwitkowski, V.3
  • 64
    • 74249089783 scopus 로고    scopus 로고
    • Phase II study of gefitinib in combination with paclitaxel (P) and carboplatin (C) as second-line therapy for ovarian, tubal or peritoneal adenocarcinoma (1839IL/0074)
    • Pautier P, Joly F, Kerbrat P, et al. Phase II study of gefitinib in combination with paclitaxel (P) and carboplatin (C) as second-line therapy for ovarian, tubal or peritoneal adenocarcinoma (1839IL/0074). Gynecol Oncol 2010;116:157-62
    • (2010) Gynecol Oncol , vol.116 , pp. 157-162
    • Pautier, P.1    Joly, F.2    Kerbrat, P.3
  • 65
    • 52049112530 scopus 로고    scopus 로고
    • A phase i study of lapatinib in combination with carboplatin in women with platinum sensitive recurrent ovarian carcinoma
    • Kimball KJ, Numnum TM, Kirby TO, et al. A phase I study of lapatinib in combination with carboplatin in women with platinum sensitive recurrent ovarian carcinoma. Gynecol Oncol 2008;111:95-101
    • (2008) Gynecol Oncol , vol.111 , pp. 95-101
    • Kimball, K.J.1    Numnum, T.M.2    Kirby, T.O.3
  • 66
    • 59449088659 scopus 로고    scopus 로고
    • Evaluation of lapatinib and topotecan combination therapy: Tissue culture, murine xenograft, and phase i clinical trial data
    • Molina JR, Kaufmann SH, Reid JM, et al. Evaluation of lapatinib and topotecan combination therapy: tissue culture, murine xenograft, and phase I clinical trial data. Clin Cancer Res 2008;14:7900-8
    • (2008) Clin Cancer Res , vol.14 , pp. 7900-7908
    • Molina, J.R.1    Kaufmann, S.H.2    Reid, J.M.3
  • 67
    • 79957697421 scopus 로고    scopus 로고
    • Phase II trial of lapatinib and topotecan (LapTop) in patients with platinumrefractory/resistant ovarian and primary peritoneal carcinoma
    • Weroha SJ, Oberg AL, Ziegler KL, et al. Phase II trial of lapatinib and topotecan (LapTop) in patients with platinumrefractory/resistant ovarian and primary peritoneal carcinoma. Gynecol Oncol 2011;122:116-20
    • (2011) Gynecol Oncol , vol.122 , pp. 116-120
    • Weroha, S.J.1    Oberg, A.L.2    Ziegler, K.L.3
  • 68
    • 84856702658 scopus 로고    scopus 로고
    • A phase II evaluation of lapatinib in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A gynecologic oncology group study
    • Garcia AA, Sill MW, Lankes HA, et al. A phase II evaluation of lapatinib in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a gynecologic oncology group study. Gynecol Oncol 2012;124:569-74
    • (2012) Gynecol Oncol , Issue.124 , pp. 569-574
    • Garcia, A.A.1    Sill, M.W.2    Lankes, H.A.3
  • 69
    • 84872300929 scopus 로고    scopus 로고
    • Expected benefits of topotecan combined with lapatinib in recurrent ovarian cancer according to biological profile: A phase 2 trial
    • Lheureux S, Krieger S, Weber B, et al. Expected benefits of topotecan combined with lapatinib in recurrent ovarian cancer according to biological profile: a phase 2 trial. Int J Gynecol Cancer 2012;22:1483-8
    • (2012) Int J Gynecol Cancer , vol.22 , pp. 1483-1488
    • Lheureux, S.1    Krieger, S.2    Weber, B.3
  • 70
    • 84884235672 scopus 로고    scopus 로고
    • Available from: http://clinicaltrials.gov/ct2/results?term= lapatinib+ovarian +cancer&Search=Search
  • 71
    • 24944486001 scopus 로고    scopus 로고
    • Multicenter, randomized phase II trial of oral CI-1033 for previously treated advanced ovarian cancer
    • Campos S, Hamid O, Seiden MV, et al. Multicenter, randomized phase II trial of oral CI-1033 for previously treated advanced ovarian cancer. J Clin Oncol 2005;23:5597-604
    • (2005) J Clin Oncol , vol.23 , pp. 5597-5604
    • Campos, S.1    Hamid, O.2    Seiden, M.V.3
  • 72
    • 34447318659 scopus 로고    scopus 로고
    • Phase II trial of imatinib mesylate in recurrent, biomarker positive, ovarian cancer (Southwest Oncology Group Protocol S0211)
    • Alberts DS, Liu PY, Wilczynski SP, et al. Phase II trial of imatinib mesylate in recurrent, biomarker positive, ovarian cancer (Southwest Oncology Group Protocol S0211). Int J Gynecol Cancer 2007;17:784-8
    • (2007) Int J Gynecol Cancer , vol.17 , pp. 784-788
    • Alberts, D.S.1    Liu, P.Y.2    Wilczynski, S.P.3
  • 73
    • 50249151509 scopus 로고    scopus 로고
    • Imatinib mesylate in combination with docetaxel for the treatment of patients with advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: A Hoosier Oncology Group trial
    • Matei D, Emerson RE, Schilder J, et al. Imatinib mesylate in combination with docetaxel for the treatment of patients with advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: a Hoosier Oncology Group trial. Cancer 2008;113:723-32
    • (2008) Cancer , vol.113 , pp. 723-732
    • Matei, D.1    Emerson, R.E.2    Schilder, J.3
  • 74
    • 49149108140 scopus 로고    scopus 로고
    • Phase II evaluation of imatinib mesylate in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: A Gynecologic Oncology Group Study
    • Schilder RJ, Sill MW, Lee RB, et al. Phase II evaluation of imatinib mesylate in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol 2008;26:3418-25
    • (2008) J Clin Oncol , vol.26 , pp. 3418-3425
    • Schilder, R.J.1    Sill, M.W.2    Lee, R.B.3
  • 75
    • 77958591106 scopus 로고    scopus 로고
    • Weekly paclitaxel with intermittent imatinib mesylate (Gleevec): Tolerance and activity in recurrent epithelial ovarian cancer
    • Safra T, Andreopoulou E, Levinson B, et al. Weekly paclitaxel with intermittent imatinib mesylate (Gleevec): tolerance and activity in recurrent epithelial ovarian cancer. Anticancer Res 2010;30:3243-7
    • (2010) Anticancer Res , Issue.30 , pp. 3243-3247
    • Safra, T.1    Andreopoulou, E.2    Levinson, B.3
  • 76
    • 84861188611 scopus 로고    scopus 로고
    • Phase II trial of imatinib mesylate in patients with recurrent platinum-and taxane-resistant low-grade serous carcinoma of the ovary, peritoneum, or fallopian tube
    • Noguera IR, Sun CC, Broaddus RR, et al. Phase II trial of imatinib mesylate in patients with recurrent platinum-and taxane-resistant low-grade serous carcinoma of the ovary, peritoneum, or fallopian tube. Gynecol Oncol 2012;125:640-5
    • (2012) Gynecol Oncol , vol.125 , pp. 640-645
    • Noguera, I.R.1    Sun, C.C.2    Broaddus, R.R.3
  • 77
    • 84866943631 scopus 로고    scopus 로고
    • A phase i trial of dasatinib, an SRC-family kinase inhibitor, in combination with paclitaxel and carboplatin in patients with advanced or recurrent ovarian cancer
    • Secord AA, Teoh DK, Barry WT, et al. A phase I trial of dasatinib, an SRC-family kinase inhibitor, in combination with paclitaxel and carboplatin in patients with advanced or recurrent ovarian cancer. Clin Cancer Res 2012;18:5489-98
    • (2012) Clin Cancer Res , vol.18 , pp. 5489-5498
    • Secord, A.A.1    Teoh, D.K.2    Barry, W.T.3
  • 78
    • 84865676963 scopus 로고    scopus 로고
    • Phase II evaluation of dasatinib in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: A Gynecologic Oncology Group study
    • Schilder RJ, Brady WE, Lankes HA, et al. Phase II evaluation of dasatinib in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 2012;127:70-4
    • (2012) Gynecol Oncol , vol.127 , pp. 70-74
    • Schilder, R.J.1    Brady, W.E.2    Lankes, H.A.3
  • 79
    • 78149359739 scopus 로고    scopus 로고
    • Predictive and prognostic angiogenic markers in a Gynecologic Oncology Group phase II trial of bevacizumab in recurrent and persistent ovarian or peritoneal cancer
    • Han ES, Burger RA, Darcy KM, et al. Predictive and prognostic angiogenic markers in a Gynecologic Oncology Group phase II trial of bevacizumab in recurrent and persistent ovarian or peritoneal cancer. Gynecol Oncol 2010;119:484-90
    • (2010) Gynecol Oncol , vol.119 , pp. 484-490
    • Han, E.S.1    Burger, R.A.2    Darcy, K.M.3
  • 80
    • 84874586305 scopus 로고    scopus 로고
    • Clinical, pharmacodynamic (PD), and pharmacokinetic (PK) evaluation of cediranib in advanced hepatocellular carcinoma (HCC): A phase II study (CTEP, 7147)
    • Zhu AX, Ancukiewicz M, Supko JG, et al. Clinical, pharmacodynamic (PD), and pharmacokinetic (PK) evaluation of cediranib in advanced hepatocellular carcinoma (HCC): a phase II study (CTEP, 7147). J Clin Oncol 2012;30:S4112
    • (2012) J Clin Oncol , vol.30
    • Zhu, A.X.1    Ancukiewicz, M.2    Supko, J.G.3
  • 81
    • 84892679460 scopus 로고    scopus 로고
    • Molecular biomarkers of response to antiangiogenic therapy for cancer
    • Duda DG. Molecular biomarkers of response to antiangiogenic therapy for cancer. ISRN Cell Biol 2012;2012:587259
    • (2012) ISRN Cell Biol , vol.2012 , pp. 587259
    • Duda, D.G.1
  • 82
    • 34249073831 scopus 로고    scopus 로고
    • Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor
    • Norden-Zfoni A, Desai J, Manola J, et al. Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor. Clin Cancer Res 2007;13:2643-50
    • (2007) Clin Cancer Res , vol.13 , pp. 2643-2650
    • Norden-Zfoni, A.1    Desai, J.2    Manola, J.3
  • 83
    • 84861661737 scopus 로고    scopus 로고
    • Biomarkers in the development of anti-angiogenic therapies for ovarian cancer
    • Raja FA, Hook JM, Ledermann JA. Biomarkers in the development of anti-angiogenic therapies for ovarian cancer. Cancer Treat Rev 2012;38:662-72
    • (2012) Cancer Treat Rev , vol.38 , pp. 662-672
    • Raja, F.A.1    Hook, J.M.2    Ledermann, J.A.3
  • 84
    • 79952022309 scopus 로고    scopus 로고
    • EGFR gene copy number as a predictive biomarker for patients receiving tyrosine kinase inhibitor treatment: A systematic review and meta-analysis in non-small-cell lung cancer
    • Dahabreh IJ, Linardou H, Kosmidis P, et al. EGFR gene copy number as a predictive biomarker for patients receiving tyrosine kinase inhibitor treatment: a systematic review and meta-analysis in non-small-cell lung cancer. Ann Oncol 2011;22:545-52
    • (2011) Ann Oncol , vol.22 , pp. 545-552
    • Dahabreh, I.J.1    Linardou, H.2    Kosmidis, P.3
  • 85
    • 84874167463 scopus 로고    scopus 로고
    • EGFR gene copy number as a prognostic marker in colorectal cancer patients treated with cetuximab or panitumumab: A systematic review and meta analysis
    • Jiang Z, Li C, Li F, Wang X. EGFR gene copy number as a prognostic marker in colorectal cancer patients treated with cetuximab or panitumumab: a systematic review and meta analysis. PLoS One 2013;8:e56205
    • (2013) PLoS One , vol.8
    • Jiang, Z.1    Li, C.2    Li, F.3    Wang, X.4
  • 86
    • 84862777672 scopus 로고    scopus 로고
    • A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer
    • Ng KP, Hillmer AM, Chuah CT, et al. A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. Nat Med 2012;18:521-8
    • (2012) Nat Med , vol.18 , pp. 521-528
    • Ng, K.P.1    Hillmer, A.M.2    Chuah, C.T.3
  • 87
    • 84866849940 scopus 로고    scopus 로고
    • Pharmacogenetic biomarkers for the prediction of response to antiangiogenic treatment
    • Schneider BP, Shen F, Miller KD. Pharmacogenetic biomarkers for the prediction of response to antiangiogenic treatment. Lancet Oncol 2012;13:e427-36
    • (2012) Lancet Oncol , vol.13
    • Schneider, B.P.1    Shen, F.2    Miller, K.D.3
  • 88
    • 79959316184 scopus 로고    scopus 로고
    • Pazopanib efficacy in renal cell carcinoma: Evidence for predictive genetic markers in angiogenesis-related and exposure-related genes
    • Xu C-F, Bing NX, Ball HA, et al. Pazopanib efficacy in renal cell carcinoma: evidence for predictive genetic markers in angiogenesis-related and exposure-related genes. J Clin Oncol 2011;29:2557-64
    • (2011) J Clin Oncol , Issue.29 , pp. 2557-2564
    • Xu, C.-F.1    Bing, N.X.2    Ball, H.A.3
  • 89
    • 81255160848 scopus 로고    scopus 로고
    • Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: A multicentre, observational, prospective study
    • Garcia-Donas J, Esteban E, Leandro-Garcia L, et al. Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study. Lancet Oncol 2011;12:1143-50
    • (2011) Lancet Oncol , vol.12 , pp. 1143-1150
    • Garcia-Donas, J.1    Esteban, E.2    Leandro-Garcia, L.3
  • 90
    • 84863338437 scopus 로고    scopus 로고
    • Association of VEGF and VEGFR2 single nucleotide polymorphisms with hypertension and clinical outcome in metastatic clear cell renal cell carcinoma patients treated with sunitinib
    • Kim JJ, Vaziri SA, Rini BI, et al. Association of VEGF and VEGFR2 single nucleotide polymorphisms with hypertension and clinical outcome in metastatic clear cell renal cell carcinoma patients treated with sunitinib. Cancer 2011;118:1946-54
    • (2011) Cancer , vol.118 , pp. 1946-1954
    • Kim, J.J.1    Vaziri, S.A.2    Rini, B.I.3
  • 92
    • 84864362871 scopus 로고    scopus 로고
    • Pushing the limits of targeted therapy in chronic myeloid leukaemia
    • O'Hare T, Zabriskie MS, Eiring AM, et al. Pushing the limits of targeted therapy in chronic myeloid leukaemia. Nat Rev Cancer 2012;12:513-26
    • (2012) Nat Rev Cancer , vol.12 , pp. 513-526
    • O'hare, T.1    Zabriskie, M.S.2    Eiring, A.M.3
  • 93
    • 84884226193 scopus 로고    scopus 로고
    • Available from: http://www.clinicaltrials.gov/ct2/show/NCT01015118?term= bibf +1120+ovarian&rank=5
  • 94
    • 79952415527 scopus 로고    scopus 로고
    • Taming the dragon: Genomic biomarkers to individualize the treatment of cancer
    • Majewski IJ, Bernards R. Taming the dragon: genomic biomarkers to individualize the treatment of cancer. Nat Med 2011;17:304-12
    • (2011) Nat Med , vol.17 , pp. 304-312
    • Majewski, I.J.1    Bernards, R.2
  • 96
    • 84883021976 scopus 로고    scopus 로고
    • Cardiovascular toxicity of tyrosine kinase inhibitors
    • [Epub ahead of print]
    • Mouhayar E, Durand JB, Cortes J. Cardiovascular toxicity of tyrosine kinase inhibitors. Expert Opin Drug Saf 2013; [Epub ahead of print]
    • (2013) Expert Opin Drug Saf
    • Mouhayar, E.1    Durand, J.B.2    Cortes, J.3


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