Progress on the pharmacological research of puerarin: A review

Chinese Journal of Natural Medicines

Volumn 12, Issue 6, 2014, Pages 407-414

  Wei, Shu Yong ^a,b   Chen, Yi ^a   Xu, Xiao Yu ^a  

^a SOUTHWEST UNIVERSITY   (China)

^b Rongchang Campus of Southwest University   (China)

Author keywords

Cardiovascular protection; Inflammation; Liver injury; Neuroprotection; Osteoporosis; Puerarin

Indexed keywords

ANTIINFLAMMATORY AGENT; BONE DENSITY CONSERVATION AGENT; CARDIOVASCULAR AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIVER PROTECTIVE AGENT; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPROTECTIVE AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PUERARIN; SUPEROXIDE DISMUTASE; ANTIOXIDANT; ISOFLAVONE DERIVATIVE; PHYTOESTROGEN; PLANT EXTRACT;

ALZHEIMER DISEASE; ANTI OSTEOPOROSIS ACTIVITY; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; DIABETES MELLITUS; DRUG ACTIVITY; EVOKED RESPONSE; HEART PROTECTION; HUMAN; HYPERLIPIDEMIA; IN VITRO STUDY; IN VIVO STUDY; LIVER INJURY; LIVER PROTECTION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PC12 CELL LINE; PUERARIA LOBATA; REPERFUSION; SYSTEMATIC REVIEW; CARDIOVASCULAR DISEASES; CHEMISTRY; DRUG EFFECTS; LIVER DISEASES; PHYTOTHERAPY; PUERARIA;

ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOPTOSIS; CARDIOVASCULAR DISEASES; HUMANS; ISOFLAVONES; LIVER DISEASES; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PHYTOESTROGENS; PHYTOTHERAPY; PLANT EXTRACTS; PUERARIA;

EID: 84904612269     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.1016/S1875-5364(14)60064-9     Document Type: Article

References (101)

1. Shibata S, Murakami T, Nishikawa Y, et al. The constituents of Pueraria root [J]. Chem Pharm Bull 1959, 1:134.
2. Penetar DM, Toto LH, Farmer SL, et al. The isoflavone puerarin reduces alcohol intake in heavy drinkers: A pilot study [J]. Drug Alcohol Depend 2012, 126(1-2):251-256.
3. Pan ZY, Bao ZS, Wu ZM, et al. The myocardial protective effects of puerarin on STZ-induced diabetic rats [J]. Fen Zi Xi Bao Sheng Wu Xue Bao 2009, 42(2):137-144.
4. Wong R, Rabie B Effect of puerarin on bone formation [J]. Osteoarthr Cart 2007, 15(8):894-899.
5. Lin F, Xie B, Cai F, et al. Protective effect of puerarin on β-amyloid-induced neurotoxicity in rat hippocampal neurons [J]. Arzneimittelforschung 2012, 62(4):187-193.
6. Yao XJ, Yin JA, Xia YF, et al. Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever in rats involving inhibition of pyrogen production from macrophages [J]. J Ethnopharmacol 2012, 141(1):322-330.
7. Zhao M, Du YQ, Yuan L, et al. Protective effect of puerarin on acute alcoholic liver injury [J]. Am J Chin Med 2010, 38(2):241-249.
8. Wang Q, Wu T, Chen X, et al. Puerarin injection for unstable angina pectoris [DB]. Cochrane Database Syst Rev 2006, 3. CD004196.
9. Tan Y, Liu M, Wu B Puerarin for acute ischaemic stroke [DB]. Cochrane Database Syst Rev 2008, 1. CD004955.
10. Wong KH, Li GQ, Li KM, et al. Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases [J]. J Ethnopharmacol 2011, 134(3):584-607.
11. Qian Y, Li Z, Huang L, et al. Blocking effect of puerarin on calcium channel in isolated guinea pig ventricular myocytes [J]. Chin Med J 1999, 112(9):787-789.
12. + current in rat ventricular myocytes [J]. Acta Pharmacol Sin 2003, 24(12):1212-1216.
13. Gao Q, Yang B, Ye ZG, et al. Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin [J]. Eur J Pharmacol 2007, 574(2-3):179-184.
14. Gao Q, Pan HY, Bruce IC, et al. Improvement of ventricular mechanical properties by puerarin involves mitochondrial permeability transition in isolated rat heart during ischemia and reperfusion [J]. Conf Proc IEEE Eng Med Biol Soc 2005, 6:5591-5594.
15. Zhang H, Zhang L, Zhang Q, et al. Puerarin: a novel antagonist to inward rectifier potassium channel (IK1) [J]. Mol Cell Biochem 2011, 352(1-2):117-123.
16. Zhang SY, Chen G, Wei PF, et al. The effect of puerarin on serum nitric oxide concentration and myocardial eNOS expression in rats with myocardial infarction [J]. J Asian Nat Prod Res 2008, 10(3-4):373-381.
17. Hwang YP, Kim HG, Hien TT, et al. Puerarin activates endothelial nitric oxide synthase through estrogen receptor- dependent PI3-kinase and calcium-dependent AMP-activated protein kinase [J]. Toxicol Appl Pharmacol 2011, 257(1):48-58.
18. 1 expression [J]. J Nutr Biochem 2012, 23(9):1080-1085.
19. Zhang NB, Huang ZG, Cui WD, et al. Effects of puerarin on expression of cardiac Smad3 and Smad7 mRNA in spontaneously hypertensive rats [J]. J Ethnopharmacol 2011, 138(3):737-740.
20. Wu L, Qiao H, Li Y, et al. Cardioprotective effects of the combined use of puerarin and Danshensu on acute ischemic myocardial injury in rats [J]. Phytother Res 2007, 21(8):751-756.
21. Yang X, Hu W, Zhang Q, et al. Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris [J]. Basic Clin Pharmacol Toxicol 2010, 107(2):637-642.
22. He H, Shi M, Yang J, et al. The correlation between angiogenesis and abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure, and improvement by puerarin [J]. Phytother Res 2008, 22(7):948-956.
23. Zhang S, Chen S, Shen Y, et al. Puerarin induces angiogenesis in myocardium of rat with myocardial infarction [J]. Biol Pharm Bull 2006, 29(5):945-950.
24. Dong K, Tao QM, Shan QX, et al. Endothelium-independent vasorelaxant effect of puerarin on rat thoracic aorta [J]. Conf Proc IEEE Eng Med Biol Soc 2004, 5:3757-3760.
25. Yan LP, Zhuang YL, Chan SW, et al. Analysis of the mechanisms underlying the endothelium-dependent antivasoconstriction of puerarin in rat aorta [J]. Naunyn Schmiedebergs Arch Pharmacol 2009, 379(6):587-597.
26. Sun XH, Ding JP, Li H, et al. Activation of large-conductance calcium-activated potassium channels by puerarin: the underlying mechanism of puerarin-mediated vasodilation [J]. J Pharmacol Exp Ther 2007, 323(1):391-397.
27. Yeung DK, Leung SW, Xu YC, et al. Puerarin, an isoflavonoid derived from Radix Puerariae, potentiates endothelium- independent relaxation via the cyclic AMP pathway in porcine coronary artery [J]. Eur J Pharmacol 2006, 552(1-3):105-111.
28. Zhu JH, Wang XX, Chen JZ, et al. Effects of puerarin on number and activity of endothelial progenitor cells from peripheral blood [J]. Acta Pharmacol Sin 2004, 25(8):1045-1051.
29. Zhu J, Wang X, Shang Y, et al. Puerarin reduces endothelial progenitor cells senescence through augmentation of telomerase activity [J]. Vascul Pharmacol 2008, 49(2-3):106-110.
30. Mao CP, Gu ZL Puerarin reduces increased c-fos, c-jun, and type IV collagen expression caused by high glucose in glomerular mesangial cells [J]. Acta Pharmacol Sin 2005, 26(8):982-986.
31. Meng XH, Ni C, Zhu L, et al. Puerarin protects against high glucose-induced acute vascular dysfunction: role of heme oxygenase-1 in rat thoracic aorta [J]. Vascul Pharmacol 2009, 50(3-4):110-115.
32. Yan LP, Chan SW, Chan AS, et al. Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats [J]. Life Sci 2006, 79(4):324-330.
33. Liu CM, Ma JQ, Sun YZ Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats [J]. Food Chem Toxicol 2011, 49(12):3119-3127.
34. Chung MJ, Sung NJ, Park CS, et al. Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice [J]. Eur J Pharmacol 2008, 578(2-3):159-170.
35. Xiong FL, Sun XH, Gan L, et al. Puerarin protects rat pancreatic islets from damage by hydrogen peroxide [J]. Eur J Pharmacol 2006, 529(1-3):1-7.
36. Hsu FL, Liu IM, Kuo DH, et al. Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats [J]. J Nat Prod 2003, 66(6):788-792.
37. Hao LN, Ling YQ, Luo XM, et al. Puerarin decreases lens epithelium cell apoptosis induced partly by peroxynitrite in diabetic rats [J]. Acta Physiol Sin 2006, 58(6):584-592.
38. Teng Y, Cui H, Yang M, et al. Protective effect of puerarin on diabetic retinopathy in rats [J]. Mol Biol Rep 2009, 36(5):1129-1133.
39. Hao LN, Zhang YQ, Shen YH, et al. Inducible nitric oxide synthase and Fas/FasL with C3 expression of mouse retinal pigment epithelial cells in response to stimulation by peroxynitrite and antagonism of puerarin [J]. Chin Med J (Engl) 2011, 124(16):2522-2529.
40. Hao LN, Wang M, Ma JL, et al. Puerarin decreases apoptosis of retinal pigment epithelial cells in diabetic rats by reducing peroxynitrite level and iNOS expression [J]. Acta Physiol Sin 2012, 64(2):199-206.
41. Hao LN, Zhang YQ, Shen YH, et al. Toxicity of endogenous peroxynitrite and effects of puerarin on transplanted retinal pigment epithelial sheets in the subretinal space in mice [J]. Int J Ophthalmol 2011, 4(3):250-254.
42. Kim J, Kim KM, Kim CS, et al. Puerarin inhibits the retinal pericyte apoptosis induced by advanced glycation end products in vitro and in vivo by inhibiting NADPH oxidase-related oxidative stress [J]. Free Radic Biol Med 2012, 53(2):357-365.
43. Zhang W, Liu CQ, Wang PW, et al. Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet [J]. Eur J Pharmacol 2010, 649(1-3):398-402.
44. Zhao Y, Zhou Y Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path [J]. Chin J Integr Med 2012, 18(4):293-298.
45. Huang F, Liu K, Du H, et al. Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKK β/IRS-1-dependent manner [J]. Biochimie 2012, 94(5):1143-1150.
46. Xu XH, Zhao TQ Effects of puerarin on D-galactose-induced memory deficits in mice [J]. Acta Pharmacol Sin 2002, 23(7):587-590.
47. Xu X, Hu Y, Ruan Q Effects of puerarin on learning-memory and amino acid transmitters of brain in ovariectomized mice [J]. Planta Med 2004, 70(7):627-631.
48. Xu X, Zhang Z Effects of puerarin on synaptic structural modification in hippocampus of ovariectomized mice [J]. Planta Med 2007, 73(10):1047-1053.
49. Wu HQ, Guo HN, Wang HQ, et al. Protective effects and mechanism of puerarin on learning-memory disorder after global cerebral ischemia-reperfusion injury in rats [J]. Chin J Integr Med 2009, 15(1):54-59.
50. Li J, Wang G, Liu J, et al. Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo [J]. Eur J Pharmacol 2010, 649(1-3):195-201.
51. Zou Y, Hong B, Fan L, et al. Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway [J]. Free Radic Res 2013, 47(1):55-63.
52. Xing G, Dong M, Li X, et al. Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway [J]. Brain Res Bull 2011, 85(3-4):212-218.
53. 2-induced apoptosis through the PI3K/Akt signalling pathway [J]. Cell Biol Int 2012, 36(5):419-426.
54. Lin CM, Lin RD, Chen ST, et al. Neurocytoprotective effects of the bioactive constituents of Pueraria thomsonii in 6-hydroxydopamine (6-OHDA)-treated nerve growth factor (NGF)-differentiated PC12 cells [J]. Phytochemistry 2010, 71(17-18):2147-2156.
55. Xu X, Zheng X Potential involvement of calcium and nitric oxide in protective effects of puerarin on oxygen-glucose deprivation in cultured hippocampal neurons [J]. J Ethnopharmacol 2007, 113(3):421-426.
56. + release triggered by KCl-depolarization in primary cultured rat hippocampal neurons [J]. Eur J Pharmacol 2007, 570(1-3):43-49.
57. + current in mice hippocampal CA1 neurons [J]. Acta Pharmacol Sin 2001, 22(3):253-256.
58. Zhang H, Liu Y, Lao M, et al. Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways [J]. Exp Gerontol 2011, 46(1):30-37.
59. Li X, Sun S, Tong E Experimental study on the protective effect of puerarin to Parkinson disease [J]. J Huazhong Univ Sci Technolog Med Sci 2003, 23(2):148-150.
60. Zhu G, Wang X, Chen Y, et al. Puerarin protects dopaminergic neurons against 6-hydroxydopamine neurotoxicity via inhibiting apoptosis and upregulating glial cell line-derived neurotrophic factor in a rat model of Parkinson's disease [J]. Planta Med 2010, 76(16):1820-1826.
61. +)- induced apoptosis in PC-12 cells [J]. Neurosci Lett 2011, 487(1):88-93.
62. +-induced neurotoxicity in PC12 cells mediated by inhibiting mitochondrial dysfunction and caspase-3-like activation [J]. Neurosci Res 2005, 53(2):183-188.
63. Zhu G, Wang X, Wu S, et al. Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against death [J]. Neurochem Int 2012, 60(4):400-408.
64. +-elicited apoptosis [J]. Neurosci Res 2009, 63(1):52-58.
65. Xu XH, Zheng XX, Zhou Q, et al. Inhibition of excitatory amino acid efflux contributes to protective effects of puerarin against cerebral ischemia in rats [J]. Biomed Environ Sci 2007, 20(4):336-342.
66. Chang Y, Hsieh CY, Peng ZA, et al. Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats [J]. J Biomed Sci 2009, 16(1):9-22.
67. Xu X, Zhang S, Zhang L, et al. The neuroprotection of puerarin against cerebral ischemia is associated with the prevention of apoptosis in rats [J]. Planta Med 2005, 71(7):585-591.
68. Wan H, Zhu H, Tian M, et al. Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia [J]. Nucl Med Commun 2008, 29(12):1113-1122.
69. Pan HP, Li G Protecting mechanism of puerarin on the brain neurocyte of rat in acute local ischemia brain injury and local cerebral ischemia-reperfusion injury [J]. Yakugaku Zasshi 2008, 128(11):1689-1698.
70. Gao L, Ji X, Song J, et al. Puerarin protects against ischemic brain injury in a rat model of transient focal ischemia [J]. Neurol Res 2009, 31(4):402-406.
71. Zhao T, Han J, Chen Y, et al. The mechanism of 3-methoxy puerarin on decreasing the cerebral ischemia-reperfusion injury in rats [J]. Asia Pac J Clin Nutr 2007, 16(Suppl 1):302-304.
72. Sang HF, Mei QB, Xu LX, et al. Effect of puerarin on neural function and histopathological damages after transient spinal cord ischemia in rabbits [J]. Chin J Traumatol 2004, 7(3):143-147.
73. Tian F, Xu LH, Zhao W, et al. The optimal therapeutic timing and mechanism of puerarin treatment of spinal cord ischemia-reperfusion injury in rats [J]. J Ethnopharmacol 2011, 134(3):892-896.
74. Dong LP, Wang TY Effects of puerarin against glutamate excitotoxicity on cultured mouse cerebral cortical neurons [J]. Acta Pharmacol Sin 1998, 19(4):339-342.
75. Gu L, Yang Y, Sun Y, et al. Puerarin inhibits acid-sensing ion channels and protects against neuron death induced by acidosis [J]. Planta Med 2010, 76(6):583-588.
76. Xu C, Xu W, Xu H, et al. Role of puerarin in the signalling of neuropathic pain mediated by P2X3 receptor of dorsal root ganglion neurons [J]. Brain Res Bull 2012, 87(1):37-43.
77. Zhou J, Wang H, Xiong Y, et al. Puerarin attenuates glutamate-induced neurofilament axonal transport impairment [J]. J Ethnopharmacol 2010, 132(1):150-156.
78. Zheng GM, Yu C, Yang Z Puerarin suppresses production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through regulating MAPK phosphorylation, O-GlcNacylation and NF-κB translocation [J]. Int J Oncol 2012, 40(5):1610-1618.
79. Hsiang SW, Lee HC, Tsai FJ, et al. Puerarin accelerates peripheral nerve regeneration [J]. Am J Chin Med 2011, 39(6):1207-1217.
80. Zhang MY, Qiang H, Yang HQ, et al. In vitro and in vivo effects of puerarin on promotion of osteoblast bone formation [J]. Chin J Integr Med 2012, 18(4):276-282.
81. Wang X, Wu J, Chiba H, et al. Puerariae radix prevents bone loss in ovariectomized mice [J]. J Bone Miner Metab 2003, 21(5):268-275.
82. Michihara S, Tanaka T, Uzawa Y, et al. Puerarin exerted anti-osteoporotic action independent of estrogen receptor- mediated pathway [J]. J Nutr Sci Vitaminol (Tokyo) 2012, 58(3):202-209.
83. Wang Y, Yin L, Li Y, et al. Preventive effects of puerarin on alcohol-induced osteonecrosis [J]. Clin Orthop Relat Res 2008, 466(5):1059-1067.
84. Liang J, Chen H, Pan W, et al. Puerarin inhibits caspase-3 expression in osteoblasts of diabetic rats [J]. Mol Med Report 2012, 5(6):1419-1422.
85. Sheu SY, Tsai CC, Sun JS, et al. Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bone morphogenetic protein-2/mitogen-activated protein kinases pathways in mice [J]. Chin Med J) 2012, 125(20):3646-3653.
86. Zhang Y, Zeng X, Zhang L, et al. Stimulatory effect of puerarin on bone formation through activation of PI3K/Akt pathway in rat calvaria osteoblasts [J]. Planta Med 2007, 73(4):341-347.
87. Tiyasatkulkovit W, Charoenphandhu N, Wongdee K, et al. Upregulation of osteoblastic differentiation marker mRNA expression in osteoblast-like UMR106 cells by puerarin and phytoestrogens from Pueraria mirifica [J]. Phytomedicine 2012, 19(13):1147-1155.
88. Wang PP, Zhu XF, Yang L, et al. Puerarin stimulates osteoblasts differentiation and bone formation through estrogen receptor, p38 MAPK, and Wnt/β-catenin pathways [J]. J Asian Nat Prod Res 2012, 14(9):897-905.
89. Zhang S, Ji G, Liu J Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin [J]. J Nutr Biochem 2006, 17(7):485-491.
90. Zheng P, Ji G, Ma Z, et al. Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways [J]. Am J Chin Med 2009, 37(1):69-83.
91. Noh BK, Lee JK, Jun HJ, et al. Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase [J]. Biochem Biophys Res Commun 2011, 414(2):361-366.
92. Hwang YP, Choi CY, Chung YC, et al. Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity [J]. Arch Pharm Res 2007, 30(10):1309-1317.
93. 4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function [J]. Food Chem Toxicol 2012, 52(2):69-75.
94. Liu CM, Ma JQ, Sun YZ Puerarin protects the rat liver against oxidative stress-mediated DNA damage and apoptosis induced by lead [J]. Exp Toxicol Pathol 2012, 64(6):575-582.
95. Liu CM, Ma JQ, Sun YZ Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats [J]. Food Chem Toxicol 2011, 49(12):3119-3127.
96. Zheng J, Chen B, Jiang B, et al. The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo [J]. Arch Pharm Res 2010, 33(2):243-246.
97. Hu W, Yang X, Zhe C, et al. Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells [J]. Pharmacol Rep 2011, 63(3):781-789.
98. Jin SE, Son YK, Min BS, et al. Anti-inflammatory and antioxidant activities of constituents isolated from Pueraria lobata roots [J]. Arch Pharm Res 2012, 35(5):823-837.
99. Xiao C, Li J, Dong X, et al. Anti-oxidative and TNF-α suppressive activities of puerarin derivative (4AC) in RAW264.7 cells and collagen-induced arthritic rats [J]. Eur J Pharmacol 2011, 666(1-3):242-250.
100. Pang W, Lan XM, Wang CB Effect of puerarin on the release of interleukin-8 in co-culture of human bronchial epithelial cells and neutrophils [J]. Chin J Integr Med 2012, 18(4):283-287.
101. Kim KM, Jung DH, Jang DS, et al. Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression [J]. Toxicol Appl Pharmacol 2010, 244(2):106-113.