Puerarin suppresses production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through regulating MAPK phosphorylation, O-GlcNAcylation and NF-κB translocation

International Journal of Oncology

Volumn 40, Issue 5, 2012, Pages 1610-1618

  Zheng, Gao Ming ^a   Yu, Chao ^a   Yang, Zhu ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Inducible nitric oxide synthase; Microglial cell; Mitogen activated protein kinase; O GlcNAcylation; Puerarin; Reactive oxygen species

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N ACETYLGLUCOSAMINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN TYROSINE KINASE; PUERARIN; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ACETYLGLUCOSAMINE; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCOSYLATION; ISOFLAVONES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; N-ACETYLGLUCOSAMINYLTRANSFERASES; NEUROPROTECTIVE AGENTS; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; TRANSCRIPTION, GENETIC;

EID: 84860310820     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1331     Document Type: Article

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