Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents

Neurobiology of Disease

Volumn 70, Issue , 2014, Pages 162-178

  Horváth, Gergely ^a,b   Gölöncsér, Flóra ^a,b   Csölle, Cecilia ^a,b   Király, Kornél ^b   Andó, Rómeó D ^a   Baranyi, Mária ^a   Koványi, Bence ^a,b   Máté, Zoltán ^a   Hoffmann, Kristina ^c   Algaier, Irina ^c   Baqi, Younis ^c,d   Müller, Christa E ^c   Von Kügelgen, Ivar ^c   Sperlágh, Beáta ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c UNIVERSITY OF BONN   (Germany)

^d SULTAN QABOOS UNIVERSITY   (Oman)

Author keywords

Inflammatory pain; Interleukin 1 ; Neuropathic pain; Purine receptor; Spinal cord

Indexed keywords

ANALGESIC AGENT; BUNGAROTOXIN RECEPTOR; CANGRELOR; CIBACRON BLUE F3GA; CLOPIDOGREL; CYTOKINE; FREUND ADJUVANT; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MRS 2395; OXIDOPAMINE; PSB 0739; PURINERGIC P2Y12 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; SURAMIN; TICLOPIDINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYCLIC AMP; P2RY12 PROTEIN, HUMAN; P2RY12 PROTEIN, MOUSE; P2RY12 PROTEIN, RAT; PURINERGIC P2Y12 RECEPTOR ANTAGONIST; RECOMBINANT RECEPTOR;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CYTOKINE PRODUCTION; DENERVATION; GENE DELETION; HINDLIMB; HOT PLATE TEST; HYPERALGESIA; INFLAMMATORY PAIN; LUMBAR SPINAL CORD; MALE; MOTOR COORDINATION; MOUSE; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; RODENT; SCIATIC NERVE; SYMPATHETIC NERVE; THROMBOCYTE AGGREGATION; UPREGULATION; VAGOTOMY; ANIMAL; C57BL MOUSE; CHIMERA; CHO CELL LINE; CRICETULUS; DISEASE MODEL; DRUG EFFECTS; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; NOCICEPTION; PAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; TUMOR CELL LINE; WISTAR RAT; CONTROLLED STUDY; EFFERENT NERVE; EXPERIMENTAL SCIATIC NERVE INJURY; HIND PAW; INFLAMMATION; MECHANICAL HYPERALGESIA; RECEPTOR BLOCKING; RODENT MODEL;

ANALGESICS; ANIMALS; CELL LINE, TUMOR; CHIMERA; CHO CELLS; CRICETULUS; CYCLIC AMP; CYTOKINES; DISEASE MODELS, ANIMAL; HUMANS; HYPERALGESIA; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; NOCICEPTION; PAIN; RATS, WISTAR; RECEPTORS, PURINERGIC P2Y12;

EID: 84904576142     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.06.011     Document Type: Article

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