A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain

British Journal of Pharmacology

Volumn 159, Issue 5, 2010, Pages 1106-1117

  Ando R D ^a   Mehesz B ^a   Gyires, K ^b   Illes, P ^c   Sperlagh B ^a,b  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Analgesia; ATP; Inflammation; Mechanical allodynia; MRS2365; MRS2395; Neuropathic pain; Nociception; Oedema; P2X1; P2X7; P2Y12; Purinergic receptors; Sciatic nerve injury

Indexed keywords

2,2 DIMETHYL PROPIONIC ACID 3 (2 CHLORO 6 METHYLAMINOPURIN 9 YL) 2 (2,2 DIMETHYLPROPIONYLOXYMETHYL)PROPYLESTER; 4,4',4'',4''' [CARBONYLBIS(IMINO 5,1,3 BENZENETRIYLBIS(CARBONYLIMINO))]TETRAKIS 1,3 BENZENEDISULFONIC ACID OCTASODIUM SALT; 8,8' [CARBONYLBIS(IMINO 3,1 PHENYLENECARBONYLIMINO)]BIS 1,3,5 NAPHTHALENE TRISULPHONIC ACID HEXASODIUM SALT; [[4 [6 AMINO 2 (METHYLTHIO) 9H PURIN 9 YL] 2,3 DIHYDROXYBICYCLO[3.1.0]HEX 1 YL]METHYLDIPHOSPHORIC ACID MONO ESTER TRISODIUM SALT; BRILLIANT BLUE G; FREUND ADJUVANT; MRS 2365; MRS 2395; NF 023; NF 449; PURINERGIC P2X RECEPTOR; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2Y RECEPTOR; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y4 RECEPTOR; PURINERGIC P2Y6 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG RECEPTOR BINDING; EDEMA; HYPERALGESIA; INFLAMMATION; MALE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT;

ANALGESICS; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; INFLAMMATION; LIGANDS; MALE; NEURALGIA; PAIN; PAIN MEASUREMENT; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2;

EID: 77949415391     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00596.x     Document Type: Article

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