-
1
-
-
84455205246
-
Alzhemier's Disease-Pathophysiology and Treatment
-
Shaik AS, Raja AE, Vijayalakshmi M, Devalarao G. Alzhemier's Disease-Pathophysiology and Treatment. Intl J Pharm Biosci 2010; 1(2): 1-11.
-
(2010)
Intl J Pharm Biosci
, vol.1
, Issue.2
, pp. 1-11
-
-
Shaik, A.S.1
Raja, A.E.2
Vijayalakshmi, M.3
Devalarao, G.4
-
2
-
-
84882939776
-
Advances in the pathogenesis of Alzheimer's disease, a re-evaluation of amyloid cascade hypothesis
-
Dong S, Duan Y, Hu Y, Zhao Z. Advances in the pathogenesis of Alzheimer's disease, a re-evaluation of amyloid cascade hypothesis. Transl Neurodegener 2012; 1: 18.
-
(2012)
Transl Neurodegener
, vol.1
, pp. 18
-
-
Dong, S.1
Duan, Y.2
Hu, Y.3
Zhao, Z.4
-
3
-
-
70349165341
-
A Peptidomimetic Approach to Targeting Pre-amyloidogenic States in Type II Diabetes
-
Hebda JA, Saraogi I, Magzoub M, Hamilton AD, Miranker AD. A Peptidomimetic Approach to Targeting Pre-amyloidogenic States in Type II Diabetes. Chem Biol 2009; 16: 943-50.
-
(2009)
Chem Biol
, vol.16
, pp. 943-950
-
-
Hebda, J.A.1
Saraogi, I.2
Magzoub, M.3
Hamilton, A.D.4
Miranker, A.D.5
-
4
-
-
54549127447
-
Impaired insulin secretion increases the risk of Alzheimer disease
-
Rönnemaa E, Zethelius B, Sundelöf J. Impaired insulin secretion increases the risk of Alzheimer disease. Neurology 2008; 71: 1065-71.
-
(2008)
Neurology
, vol.71
, pp. 1065-1071
-
-
Rönnemaa, E.1
Zethelius, B.2
Sundelöf, J.3
-
5
-
-
84879077265
-
AD in the United States (2010-2050) estimated using the 2010 Census
-
Herbert LE, Weuve J, Scherr PA, Evans DA. AD in the United States (2010-2050) estimated using the 2010 Census. Neurology 2013; 80(19): 1778-83.
-
(2013)
Neurology
, vol.80
, Issue.19
, pp. 1778-1783
-
-
Herbert, L.E.1
Weuve, J.2
Scherr, P.A.3
Evans, D.A.4
-
6
-
-
78049460615
-
The Global Economic Impact of Dementia
-
World Alzheimer Report
-
World Alzheimer Report, 2010. The Global Economic Impact of Dementia. Alzheimer's Disease International, 2010; p. 15.
-
(2010)
Alzheimer's Disease International
, vol.2010
, pp. 15
-
-
-
7
-
-
84864956573
-
Type 2 Diabetes Mellitus in Arabic-Speaking Countries
-
Badran M, Laher I. Type 2 Diabetes Mellitus in Arabic-Speaking Countries. Int J Endocrin 2012; 11: 902873.
-
Int J Endocrin
, vol.11
, Issue.90
, pp. 2012
-
-
Badran, M.1
Laher, I.2
-
8
-
-
0032764016
-
Diabetes mellitus and the risk of dementia, the Rotterdam Study
-
Ott A, Stolk RP, van Harskamp F, et al. Diabetes mellitus and the risk of dementia, the Rotterdam Study. Neurology 1999; 53: 1937-42.
-
(1999)
Neurology
, vol.53
, pp. 1937-1942
-
-
Ott, A.1
Stolk, R.P.2
van Harskamp, F.3
-
9
-
-
74049099554
-
The relationship between Alzheimer's disease and diabetes, type 3 diabetes?
-
Kroner Z. The relationship between Alzheimer's disease and diabetes, type 3 diabetes? Altern Med Rev 2009; 14: 373-9.
-
(2009)
Altern Med Rev
, vol.14
, pp. 373-379
-
-
Kroner, Z.1
-
10
-
-
36949038203
-
The role of peroxisome proliferatoractivated receptor-gamma (PPARgamma) in Alzheimer's disease, therapeutic implications
-
Jiang Q, Heneka M, Landreth GE. The role of peroxisome proliferatoractivated receptor-gamma (PPARgamma) in Alzheimer's disease, therapeutic implications. CNS Drugs 2008; 22: 1-14.
-
(2008)
CNS Drugs
, vol.22
, pp. 1-14
-
-
Jiang, Q.1
Heneka, M.2
Landreth, G.E.3
-
11
-
-
77951028451
-
Diabetes accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in Alzheimer mouse model with diabetes
-
Takeda S, Sato N, Uchio-Yamada K, et al. Diabetes accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in Alzheimer mouse model with diabetes. Proc Natl Acad Sci USA 2010; 107: 7036-41.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 7036-7041
-
-
Takeda, S.1
Sato, N.2
Uchio-Yamada, K.3
-
12
-
-
33644591150
-
Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease, link to brain reductions in acetylcholine
-
Rivera EJ, Goldin A, Fulmer N, et al. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease, link to brain reductions in acetylcholine. J Alzheimers Dis 2005; 8: 247-68.
-
(2005)
J Alzheimers Dis
, vol.8
, pp. 247-268
-
-
Rivera, E.J.1
Goldin, A.2
Fulmer, N.3
-
13
-
-
70349505965
-
Role of the JNKinteracting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes
-
Beeler N, Riederer BM, Waeber G, Abderrahmani A. Role of the JNKinteracting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes. Brain Res Bull 2009; 80: 274-81.
-
(2009)
Brain Res Bull
, vol.80
, pp. 274-281
-
-
Beeler, N.1
Riederer, B.M.2
Waeber, G.3
Abderrahmani, A.4
-
14
-
-
77954955774
-
Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes
-
Miklossy J, Qing H, Radenovic A, et al. Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiol Aging 2010; 31: 1503-15.
-
(2010)
Neurobiol Aging
, vol.31
, pp. 1503-1515
-
-
Miklossy, J.1
Qing, H.2
Radenovic, A.3
-
15
-
-
15244351255
-
Impaired insulin and insulin-like growth factor expres-sion and signaling mechanisms in AD-is this type 3 diabetes?
-
Steen E, Terry BM, Rivera EJ, et al. Impaired insulin and insulin-like growth factor expres-sion and signaling mechanisms in AD-is this type 3 diabetes? J Alzheimers Dis 2005; 7(1): 63-80.
-
(2005)
J Alzheimers Dis
, vol.7
, Issue.1
, pp. 63-80
-
-
Steen, E.1
Terry, B.M.2
Rivera, E.J.3
-
16
-
-
38549152764
-
Why Alzheimer's is a disease of memory, the attack on synapses by A beta oligomers (ADDLs)
-
Viola KL, Velasco PT, Klein WL. Why Alzheimer's is a disease of memory, the attack on synapses by A beta oligomers (ADDLs). J Nutr Health Aging 2008; 12: 51-7.
-
(2008)
J Nutr Health Aging
, vol.12
, pp. 51-57
-
-
Viola, K.L.1
Velasco, P.T.2
Klein, W.L.3
-
17
-
-
33748755428
-
Therapeutic rescue of neurodegeneration in experimental type 3 diabetes, relevance to AD
-
de la Monte SM, Tong M, Lester-Coll N. Therapeutic rescue of neurodegeneration in experimental type 3 diabetes, relevance to AD. J Alzheimers Dis 2006; 10: 89-109.
-
(2006)
J Alzheimers Dis
, vol.10
, pp. 89-109
-
-
de la Monte, S.M.1
Tong, M.2
Lester-Coll, N.3
-
18
-
-
0037221379
-
The role of insulin resistance in the pathogenesis of AD, implications for treatment
-
Watson GS, Craft S. The role of insulin resistance in the pathogenesis of AD, implications for treatment. CNS Drugs 2003; 17: 27-45.
-
(2003)
CNS Drugs
, vol.17
, pp. 27-45
-
-
Watson, G.S.1
Craft, S.2
-
20
-
-
0034508636
-
Insulin receptors and insulin action in the nervous system
-
Freychet P. Insulin receptors and insulin action in the nervous system. Diabetes Metab Res Rev 2000; 16: 390-2.
-
(2000)
Diabetes Metab Res Rev
, vol.16
, pp. 390-392
-
-
Freychet, P.1
-
21
-
-
0036895563
-
The role of insulin in human brain glucose metabolism, an 18fluoro-deoxyglucose positron emission tomography study
-
Bingham EM, Hopkins D, Smith D. The role of insulin in human brain glucose metabolism, an 18fluoro-deoxyglucose positron emission tomography study. Diabetes 2002; 51: 3384-90.
-
(2002)
Diabetes
, vol.51
, pp. 3384-3390
-
-
Bingham, E.M.1
Hopkins, D.2
Smith, D.3
-
22
-
-
1242316296
-
Insulin and neurodegenerative disease, shared and specific mechanisms
-
Craft S, Watson GS. Insulin and neurodegenerative disease, shared and specific mechanisms. Lancet Neurol 2004; 3: 169-78.
-
(2004)
Lancet Neurol
, vol.3
, pp. 169-178
-
-
Craft, S.1
Watson, G.S.2
-
23
-
-
0035947044
-
Role of insulin and insulin receptor in learning and memory
-
Zhao WQ, Alkon DL. Role of insulin and insulin receptor in learning and memory. Mol. Cell Endocrinol 2001; 177: 125-34.
-
(2001)
Mol. Cell Endocrinol
, vol.177
, pp. 125-134
-
-
Zhao, W.Q.1
Alkon, D.L.2
-
24
-
-
4243226403
-
Developmental regulation of the insulin and insulin-like growth factor receptors in the central nervous system
-
Zagon IS, McLaughlin PJ, Eds.; London, Chapman and Hall
-
Werner H, Roberts, CTJ, Raizada MK, et al. Developmental regulation of the insulin and insulin-like growth factor receptors in the central nervous system. In: Receptors in the Developing Nervous System; Zagon IS, McLaughlin PJ, Eds.; London, Chapman and Hall 1993; pp. 109-27.
-
(1993)
Receptors In the Developing Nervous System
, pp. 109-127
-
-
Werner, H.1
Roberts, C.T.J.2
Raizada, M.K.3
-
25
-
-
79251623365
-
Diabetes mellitus and AD, shared pathology and treatment?
-
Akter K, Lanza EA, Martin SA, et al. Diabetes mellitus and AD, shared pathology and treatment? Br J Clin Pharmacol 2011; 71(3): 365-76.
-
(2011)
Br J Clin Pharmacol
, vol.71
, Issue.3
, pp. 365-376
-
-
Akter, K.1
Lanza, E.A.2
Martin, S.A.3
-
26
-
-
70349581633
-
Insulin resistance and Alzheimers's disease
-
de la Monte SM. Insulin resistance and Alzheimers's disease. BMB Rep 2009; 42: 475-81.
-
(2009)
BMB Rep
, vol.42
, pp. 475-481
-
-
de la Monte, S.M.1
-
27
-
-
0036489445
-
The relationship between Abeta and memory in the Tg2576 mouse model of AD
-
Westerman MA, Cooper-Blacketer D, Mariash A. The relationship between Abeta and memory in the Tg2576 mouse model of AD. J Neurosci 2002; 22: 1858-67.
-
(2002)
J Neurosci
, vol.22
, pp. 1858-1867
-
-
Westerman, M.A.1
Cooper-Blacketer, D.2
Mariash, A.3
-
28
-
-
36448936053
-
Common pathological processes in Alzheimer disease and type 2 diabetes, a review
-
Li L, Holscher C. Common pathological processes in Alzheimer disease and type 2 diabetes, a review. Brain Res Rev 2007; 56: 384-402.
-
(2007)
Brain Res Rev
, vol.56
, pp. 384-402
-
-
Li, L.1
Holscher, C.2
-
30
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh DM, Klyubin I, Fadeeva JV, et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002; 416: 535-9.
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
-
31
-
-
0009364134
-
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease
-
Kosik KS, Joachim CL, Selkoe DJ. Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci USA 1986; 83: 4044-8.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 4044-4048
-
-
Kosik, K.S.1
Joachim, C.L.2
Selkoe, D.J.3
-
32
-
-
0036796875
-
Oxidative stress and stress-activated signaling pathways, a unifying hypothesis of type 2 diabetes
-
Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidative stress and stress-activated signaling pathways, a unifying hypothesis of type 2 diabetes. Endocr Rev 2002; 23: 599-622.
-
(2002)
Endocr Rev
, vol.23
, pp. 599-622
-
-
Evans, J.L.1
Goldfine, I.D.2
Maddux, B.A.3
Grodsky, G.M.4
-
33
-
-
0037222391
-
Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy
-
Schmeichel AM, Schmelzer JD, Low PA. Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy. Diabetes 2003; 52: 165-71.
-
(2003)
Diabetes
, vol.52
, pp. 165-171
-
-
Schmeichel, A.M.1
Schmelzer, J.D.2
Low, P.A.3
-
34
-
-
0034864018
-
Mitochondrial involvement in brain function and dysfunction, relevance to aging, neurodegenerative disorders and longevity
-
Calabrese V, Scapagnini G, Giuffrida SAM, Bates TE, Clark JB. Mitochondrial involvement in brain function and dysfunction, relevance to aging, neurodegenerative disorders and longevity. Neurochem Res 2001; 26: 739-64.
-
(2001)
Neurochem Res
, vol.26
, pp. 739-764
-
-
Calabrese, V.1
Scapagnini, G.2
Giuffrida, S.A.M.3
Bates, T.E.4
Clark, J.B.5
-
35
-
-
0034962860
-
Mitochondria and degenerative disorders
-
Orth M, Schapira AH. Mitochondria and degenerative disorders. Am J Med Genet 2001; 106: 27-36.
-
(2001)
Am J Med Genet
, vol.106
, pp. 27-36
-
-
Orth, M.1
Schapira, A.H.2
-
36
-
-
47049120422
-
AD-type neuronal tau hyperphosphorylation induced by A beta oligomers
-
De Felice FG, Wu D, Lambert MP. AD-type neuronal tau hyperphosphorylation induced by A beta oligomers. Neurobiol Aging 2008; 29: 1334-47.
-
(2008)
Neurobiol Aging
, vol.29
, pp. 1334-1347
-
-
de Felice, F.G.1
Wu, D.2
Lambert, M.P.3
-
37
-
-
77954546616
-
Type 2 Diabetes Mellitus, Dyslipidemia and AD
-
Carlsson CM. Type 2 Diabetes Mellitus, Dyslipidemia and AD. J Alzheimer Dis 2010; 20: 711-22.
-
(2010)
J Alzheimer Dis
, vol.20
, pp. 711-722
-
-
Carlsson, C.M.1
-
38
-
-
0037390039
-
Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
-
Farris W, Mansourian S, Chang Y, et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo. PNAS 2003; 100(7): 4162-7.
-
(2003)
PNAS
, vol.100
, Issue.7
, pp. 4162-4167
-
-
Farris, W.1
Mansourian, S.2
Chang, Y.3
-
40
-
-
29844432266
-
Insulin, insulin-degrading enzyme and amyloidbeta peptide in AD, review and hypothesis
-
Qiu WQ, Folstein MF. Insulin, insulin-degrading enzyme and amyloidbeta peptide in AD, review and hypothesis. Neurobiol Aging 2006; 27: 190-8.
-
(2006)
Neurobiol Aging
, vol.27
, pp. 190-198
-
-
Qiu, W.Q.1
Folstein, M.F.2
-
41
-
-
60349088206
-
Insulin-degrading enzyme is exported via an unconventional protein secretion pathway
-
Zhao J, Li L, Leissring MA. Insulin-degrading enzyme is exported via an unconventional protein secretion pathway. Mol Neurodegener 2009; 4: 4.
-
(2009)
Mol Neurodegener
, vol.4
, pp. 4
-
-
Zhao, J.1
Li, L.2
Leissring, M.A.3
-
42
-
-
0037219221
-
Reduced hippocampal insulin-degrading enzyme in late-onset AD is associated with the apolipoprotein E-epsilon4 allele
-
Cook DG, Leverenz JB, McMillan PJ, et al. Reduced hippocampal insulin-degrading enzyme in late-onset AD is associated with the apolipoprotein E-epsilon4 allele. Am J Pathol 2003; 162: 313-9.
-
(2003)
Am J Pathol
, vol.162
, pp. 313-319
-
-
Cook, D.G.1
Leverenz, J.B.2
McMillan, P.J.3
-
43
-
-
44649197748
-
ApoE promotes the proteolytic degradation of Abeta
-
Jiang Q, Lee CY, Mandrekar S, et al. ApoE promotes the proteolytic degradation of Abeta. Neuron 2008; 58: 681-93.
-
(2008)
Neuron
, vol.58
, pp. 681-693
-
-
Jiang, Q.1
Lee, C.Y.2
Mandrekar, S.3
-
44
-
-
34249895023
-
Replication of genomewide association signals in UK samples reveals risk loci for type 2 diabetes
-
Zeggini E, Weedon MN, Lindgren CM, et al. Replication of genomewide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007; 316: 1336-41.
-
(2007)
Science
, vol.316
, pp. 1336-1341
-
-
Zeggini, E.1
Weedon, M.N.2
Lindgren, C.M.3
-
45
-
-
84873817119
-
Insulin-degrading enzyme (IDE): A novel heat shock-like protein
-
Tundo GR, Sbardella D, Ciaccio C, et al. Insulin-degrading enzyme (IDE): a novel heat shock-like protein. J Biol Chem 2013; 288(4): 2281-9.
-
(2013)
J Biol Chem
, vol.288
, Issue.4
, pp. 2281-2289
-
-
Tundo, G.R.1
Sbardella, D.2
Ciaccio, C.3
-
47
-
-
33746932145
-
Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils
-
Hatters DM, Zhong N, Rutenber E, Weisgraber KH. Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils. J Mol Biol 2006; 361: 932-44.
-
(2006)
J Mol Biol
, vol.361
, pp. 932-944
-
-
Hatters, D.M.1
Zhong, N.2
Rutenber, E.3
Weisgraber, K.H.4
-
48
-
-
70450219539
-
Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease
-
Martins IJ, Berger T, Sharman MJ, et al. Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease. J Neurochem 2009; 111: 1275-308.
-
(2009)
J Neurochem
, vol.111
, pp. 1275-1308
-
-
Martins, I.J.1
Berger, T.2
Sharman, M.J.3
-
49
-
-
0035927426
-
Secretase targets for AD, identification and therapeutic potential
-
Wolfe MS. Secretase targets for AD, identification and therapeutic potential. J Med Chem 2001; 44: 2039-60.
-
(2001)
J Med Chem
, vol.44
, pp. 2039-2060
-
-
Wolfe, M.S.1
-
51
-
-
79952787104
-
Early-Onset Familial Alzheimer Disease Reviews
-
Pagon RA, Adam MP, Ardinger HH, et al. University of Washington, Seatle
-
Bird TD. Early-Onset Familial Alzheimer Disease. In: Pagon RA, Adam MP, Ardinger HH, et al., Eds. Gene Reviews. University of Washington, Seatle 2007; pp. 1993-2014.
-
(2007)
Gene Reviews
, pp. 1993-2014
-
-
Bird, T.D.1
-
52
-
-
0038240721
-
Causative and susceptibility genes for AD, a review
-
Rocchi A, Pellegrini S, Siciliano G, Murri L. Causative and susceptibility genes for AD, a review. Brain Res Bull 2003; 61(1): 1-24.
-
(2003)
Brain Res Bull
, vol.61
, Issue.1
, pp. 1-24
-
-
Rocchi, A.1
Pellegrini, S.2
Siciliano, G.3
Murri, L.4
-
53
-
-
84873722367
-
Apolipoprotein E and Alzheimer disease, risk, mechanisms and therapy
-
Liu CC, Kanekiyo T, Xu H, Bu G. Apolipoprotein E and Alzheimer disease, risk, mechanisms and therapy. Nat Rev Neurol 2013; 1-13.
-
(2013)
Nat Rev Neurol
, pp. 1-13
-
-
Liu, C.C.1
Kanekiyo, T.2
Xu, H.3
Bu, G.4
-
54
-
-
14044273751
-
Hippocampal synaptic modulation by the phosphotyrosine adapter protein AhcC/N-Shc via interaction with the NMDA receptor
-
Miyamoto Y, Chen L, Sato M, et al. Hippocampal synaptic modulation by the phosphotyrosine adapter protein AhcC/N-Shc via interaction with the NMDA receptor. J Neurosci 2005; 16: 1826-35.
-
(2005)
J Neurosci
, vol.16
, pp. 1826-1835
-
-
Miyamoto, Y.1
Chen, L.2
Sato, M.3
-
55
-
-
33745215607
-
Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat
-
Horwood JM, Dufour F, Laroche S, Davis S. Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat. Eur J Neurosci 2006; 23: 3375-84.
-
(2006)
Eur J Neurosci
, vol.23
, pp. 3375-3384
-
-
Horwood, J.M.1
Dufour, F.2
Laroche, S.3
Davis, S.4
-
56
-
-
24944532213
-
PI3 kinase signaling is required for retrieval and extinction of contextual memory
-
Chen X, Garelick MG, Wang H, et al. PI3 kinase signaling is required for retrieval and extinction of contextual memory. Nat Neurosci 2005; 8: 925-31.
-
(2005)
Nat Neurosci
, vol.8
, pp. 925-931
-
-
Chen, X.1
Garelick, M.G.2
Wang, H.3
-
57
-
-
77951060396
-
PI3 kinase signaling is involved in Aβ-induced memory loss in Drosophila
-
Chiang HC, Wang L, Xie Z, Yau A, Zhong Y. PI3 kinase signaling is involved in Aβ-induced memory loss in Drosophila. Proc Natl Acad Sci USA 2010; 107: 7060-5.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 7060-7065
-
-
Chiang, H.C.1
Wang, L.2
Xie, Z.3
Yau, A.4
Zhong, Y.5
-
58
-
-
0030800192
-
Recruitment of functional GABAA receptors to postsynaptic domains by insulin
-
Wan Q, Xiong ZG, Man HY, et al. Recruitment of functional GABAA receptors to postsynaptic domains by insulin. Nature 1997; 388: 686-90.
-
(1997)
Nature
, vol.388
, pp. 686-690
-
-
Wan, Q.1
Xiong, Z.G.2
Man, H.Y.3
-
59
-
-
2342496712
-
FOXOs at the crossroads of cellular metabolism, differentiation, and transformation
-
Accili D, Arden KC. FOXOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 2004; 117: 421-6.
-
(2004)
Cell
, vol.117
, pp. 421-426
-
-
Accili, D.1
Arden, K.C.2
-
60
-
-
34249281690
-
Stressing the role of FOXO proteins in lifespan and disease
-
van der Horst A, Burgering BM. Stressing the role of FOXO proteins in lifespan and disease. Nat Rev Mol. Cell Biol 2007; 8: 440-50.
-
(2007)
Nat Rev Mol. Cell Biol
, vol.8
, pp. 440-450
-
-
van der Horst, A.1
Burgering, B.M.2
-
61
-
-
34548289502
-
Dynamic FOXO transcription factors
-
Huang H, Tindall DJ. Dynamic FOXO transcription factors. J Cell Sci 2007; 120: 2479-87.
-
(2007)
J Cell Sci
, vol.120
, pp. 2479-2487
-
-
Huang, H.1
Tindall, D.J.2
-
62
-
-
27844497945
-
FOXO transcription factors at the interface between longevity and tumor suppression
-
Greer EL, Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 2005; 24: 7410-25.
-
(2005)
Oncogene
, vol.24
, pp. 7410-7425
-
-
Greer, E.L.1
Brunet, A.2
-
63
-
-
77958494422
-
Linking Alzheimer's disease to insulin resistance, the FOXO response to oxidative stress
-
Manolopoulos KN, Klotz L-O, Korsten P, Bornstein SR, Barthel A. Linking Alzheimer's disease to insulin resistance, the FOXO response to oxidative stress. Mol Psychiatry 2010; 15: 1046-52.
-
(2010)
Mol Psychiatry
, vol.15
, pp. 1046-1052
-
-
Manolopoulos, K.N.1
Klotz, L.-O.2
Korsten, P.3
Bornstein, S.R.4
Barthel, A.5
-
64
-
-
33749074277
-
Neuronal macroautophagy, from development to degeneration
-
Boland B, Nixon RA. Neuronal macroautophagy, from development to degeneration. Mol Aspects Med 2006; 27(5-6): 503-19.
-
(2006)
Mol Aspects Med
, vol.27
, Issue.5-6
, pp. 503-519
-
-
Boland, B.1
Nixon, R.A.2
-
65
-
-
0042733013
-
Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production
-
Grbovic OM, Mathews PM, Jiang Y. Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production. J Biol Chem 2003; 278: 31261-8.
-
(2003)
J Biol Chem
, vol.278
, pp. 31261-31268
-
-
Grbovic, O.M.1
Mathews, P.M.2
Jiang, Y.3
-
66
-
-
0037698096
-
Presenilin-1: Nicastrin, amyloid precursor protein and gamma-secretase activity are co-localized in the lysosomal membrane
-
Pasternak SH, Bagshaw RD, Guiral M. Presenilin-1: nicastrin, amyloid precursor protein and gamma-secretase activity are co-localized in the lysosomal membrane. J Biol Chem 2003; 278: 26687-94.
-
(2003)
J Biol Chem
, vol.278
, pp. 26687-26694
-
-
Pasternak, S.H.1
Bagshaw, R.D.2
Guiral, M.3
-
67
-
-
0034304390
-
The endosomal-lysosomal system of neurons in AD pathogenesis, a review
-
Nixon RA, Cataldo AM, Mathews PM. The endosomal-lysosomal system of neurons in AD pathogenesis, a review. Neurochem Res 2000; 25: 1161-72.
-
(2000)
Neurochem Res
, vol.25
, pp. 1161-1172
-
-
Nixon, R.A.1
Cataldo, A.M.2
Mathews, P.M.3
-
69
-
-
0032730787
-
Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation
-
Terman A, Dalen H, Brunk UT. Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation. Exp Gerontol 1999; 34(8): 943-57.
-
(1999)
Exp Gerontol
, vol.34
, Issue.8
, pp. 943-957
-
-
Terman, A.1
Dalen, H.2
Brunk, U.T.3
-
70
-
-
0036359773
-
Protein degradation in the aging organism
-
Ward WF. Protein degradation in the aging organism. Prog Mol Subcell Biol 2002; 29: 35-42.
-
(2002)
Prog Mol Subcell Biol
, vol.29
, pp. 35-42
-
-
Ward, W.F.1
-
71
-
-
84860372433
-
Induction of autophagy by palmitic acid via a PKC-mediated signalling pathway independent of mTOR
-
Tan SH, Shui G, Zhou J, et al. Induction of autophagy by palmitic acid via a PKC-mediated signalling pathway independent of mTOR. J Biol Chem 2012; 287(18): 14364-76.
-
(2012)
J Biol Chem
, vol.287
, Issue.18
, pp. 14364-14376
-
-
Tan, S.H.1
Shui, G.2
Zhou, J.3
-
72
-
-
67349150186
-
Autophagy in human type 2 diabetes pancreatic beta cells
-
Masini M, Bugliani M, Lupi R, et al. Autophagy in human type 2 diabetes pancreatic beta cells. Diabetologia 2009; 52: 1083-6.
-
(2009)
Diabetologia
, vol.52
, pp. 1083-1086
-
-
Masini, M.1
Bugliani, M.2
Lupi, R.3
-
73
-
-
78149433116
-
Role of epigenetics in Alzheimer's and Parkinson's disease
-
Kwok JBJ. Role of epigenetics in Alzheimer's and Parkinson's disease. Epigenomics 2010; 2(5): 671-82.
-
(2010)
Epigenomics
, vol.2
, Issue.5
, pp. 671-682
-
-
Kwok, J.B.J.1
-
74
-
-
0035798238
-
The molecular biology of memory storage, a dialogue between genes and synapses
-
Kandel ER. The molecular biology of memory storage, a dialogue between genes and synapses. Science 2001; 294(5544): 1030-8.
-
(2001)
Science
, vol.294
, Issue.5544
, pp. 1030-1038
-
-
Kandel, E.R.1
-
75
-
-
79955622702
-
Epigenetic regulation of gene expression in physiological and pathological brain processes
-
Graff J, Kim D, Dobbin MM, Tsai LH. Epigenetic regulation of gene expression in physiological and pathological brain processes. Physiol Rev 2011; 91(2): 603-49.
-
(2011)
Physiol Rev
, vol.91
, Issue.2
, pp. 603-649
-
-
Graff, J.1
Kim, D.2
Dobbin, M.M.3
Tsai, L.H.4
-
76
-
-
0029984469
-
Tetrahymena histone acetyltransferase A, a homolog to yeast Gcn5p linking histone acetylation to gene activation
-
Brownell JE, Zhou J, Ranalli T, et al. Tetrahymena histone acetyltransferase A, a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 1996; 84(6): 843-51.
-
(1996)
Cell
, vol.84
, Issue.6
, pp. 843-851
-
-
Brownell, J.E.1
Zhou, J.2
Ranalli, T.3
-
78
-
-
49049122193
-
AD and vascular dementia in developing countries, prevalence, management and risk factors
-
Kalaria RN, Maestre GE, Arizaga R, Friedland RP, Antuono P. AD and vascular dementia in developing countries, prevalence, management and risk factors. Lancet Neurol 2008; 7: 812-26.
-
(2008)
Lancet Neurol
, vol.7
, pp. 812-826
-
-
Kalaria, R.N.1
Maestre, G.E.2
Arizaga, R.3
Friedland, R.P.4
Antuono, P.5
-
79
-
-
84859001154
-
Association between mid-life marital status and cognitive function in later life, population based cohort study
-
Hakansson K, Rovio S, Helkala EL, Vilska AR, Kivipelto M. Association between mid-life marital status and cognitive function in later life, population based cohort study. Br Med J 2009; 339: 2462.
-
(2009)
Br Med J
, vol.339
, pp. 2462
-
-
Hakansson, K.1
Rovio, S.2
Helkala, E.L.3
Vilska, A.R.4
Kivipelto, M.5
-
80
-
-
68849119553
-
Physical activity, diet and risk of Alzheimer disease
-
Scarmeas N, Luchsinger JA, Schupf N, et al. Physical activity, diet and risk of Alzheimer disease. JAMA 2009; 302: 627-37.
-
(2009)
JAMA
, vol.302
, pp. 627-637
-
-
Scarmeas, N.1
Luchsinger, J.A.2
Schupf, N.3
-
81
-
-
38449106861
-
Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors, basic concepts and clinical applications
-
Mund C, Brueckner B, Lyko F. Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors, basic concepts and clinical applications. Epigenetics 2006; 1: 7-13.
-
(2006)
Epigenetics
, vol.1
, pp. 7-13
-
-
Mund, C.1
Brueckner, B.2
Lyko, F.3
-
82
-
-
10044221016
-
Colorectal cancers in a new mouse model of familial adenomatous polyposis, influence of genetic and environmental modifiers
-
Colnot S, Niwa-Kawakita M, Hamard G, Godard C, Perret C. Colorectal cancers in a new mouse model of familial adenomatous polyposis, influence of genetic and environmental modifiers. Lab Invest 2004; 84: 1619-30.
-
(2004)
Lab Invest
, vol.84
, pp. 1619-1630
-
-
Colnot, S.1
Niwa-Kawakita, M.2
Hamard, G.3
Godard, C.4
Perret, C.5
-
83
-
-
0022540321
-
CpG-rich islands and the function of DNA methylation
-
Bird AP. CpG-rich islands and the function of DNA methylation. Nature 1986; 321: 209-13.
-
(1986)
Nature
, vol.321
, pp. 209-213
-
-
Bird, A.P.1
-
84
-
-
43549084587
-
Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes
-
Vaxillaire M, Froguel P. Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes. Endocr Rev 2008; 29: 254-64.
-
(2008)
Endocr Rev
, vol.29
, pp. 254-264
-
-
Vaxillaire, M.1
Froguel, P.2
-
85
-
-
0037326196
-
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): Transcriptional coactivator and metabolic regulator
-
Puigserver P, Spiegelman BM. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev 2003; 24: 78-90.
-
(2003)
Endocr Rev
, vol.24
, pp. 78-90
-
-
Puigserver, P.1
Spiegelman, B.M.2
-
86
-
-
41149172495
-
Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion
-
Ling C, Del Guerra S, Lupi R, et al. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia 2008; 51: 615-22.
-
(2008)
Diabetologia
, vol.51
, pp. 615-622
-
-
Ling, C.1
Del, G.S.2
Lupi, R.3
-
87
-
-
26944456359
-
Rivastigmine is a potent inhibitor of acetyl-and butyrylcholinesterase in Alzheimer's plaques and tangles
-
Mariam F, Eskander NGN, Elaine YL, Bahiyyih K. Rivastigmine is a potent inhibitor of acetyl-and butyrylcholinesterase in Alzheimer's plaques and tangles. Brain Res 2005; 1060: 144-52.
-
(2005)
Brain Res
, vol.1060
, pp. 144-152
-
-
Mariam, F.1
Eskander, N.G.N.2
Elaine, Y.L.3
Bahiyyih, K.4
-
88
-
-
0343962228
-
Effect of streptozotocin induced diabetes on activities of cholinesterases in the rat retina
-
Sanchez CG, Salceda R. Effect of streptozotocin induced diabetes on activities of cholinesterases in the rat retina. IUBMB Life 2000; 49: 283-7.
-
(2000)
IUBMB Life
, vol.49
, pp. 283-287
-
-
Sanchez, C.G.1
Salceda, R.2
-
89
-
-
28044437122
-
Selective butyrylcholinsterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer's ß-amyloid peptide in rodent
-
Greig NH, Utsuki T, Ingram DK, Wang Y, Pepeu G. Selective butyrylcholinsterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer's ß-amyloid peptide in rodent. Proc Natl Acad Sci USA 2005; 102: 17213-8.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17213-17218
-
-
Greig, N.H.1
Utsuki, T.2
Ingram, D.K.3
Wang, Y.4
Pepeu, G.5
-
90
-
-
33746377894
-
Protein misfolding, functional amyloid and human disease
-
Chiti F, Dobson CM. Protein misfolding, functional amyloid and human disease. Annu Rev Biochem 2006; 75(1): 333-66.
-
(2006)
Annu Rev Biochem
, vol.75
, Issue.1
, pp. 333-366
-
-
Chiti, F.1
Dobson, C.M.2
-
91
-
-
0037551741
-
Proto fibrils, pores, fibrils and neurodegeneration, separating the responsible protein aggregates from the innocent bystanders
-
Caughey B, Lansbury PT. Proto fibrils, pores, fibrils and neurodegeneration, separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci 2003; 26(1): 267-98.
-
(2003)
Annu Rev Neurosci
, vol.26
, Issue.1
, pp. 267-298
-
-
Caughey, B.1
Lansbury, P.T.2
-
92
-
-
77950810299
-
Protein folding, the dark side of proteins
-
Schnabel J. Protein folding, the dark side of proteins. Nature 2010; 464(7290): 828-9.
-
(2010)
Nature
, vol.464
, Issue.7290
, pp. 828-829
-
-
Schnabel, J.1
-
93
-
-
79952748803
-
Low-resolution structure of a vesicle disrupting & α,-synuclein oligomer that accumulates during fibrillation
-
Giehm L, Svergun DI, Otzen DE, Vestergaard B. Low-resolution structure of a vesicle disrupting & α,-synuclein oligomer that accumulates during fibrillation. Proc Natl Acad Sci USA 2011; 108(8): 3246-51.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.8
, pp. 3246-3251
-
-
Giehm, L.1
Svergun, D.I.2
Otzen, D.E.3
Vestergaard, B.4
-
94
-
-
0023579739
-
Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients
-
Cooper GJ, Willis AC, Clark A, et al. Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 1987; 84(23): 8628-32.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, Issue.23
, pp. 8628-8632
-
-
Cooper, G.J.1
Willis, A.C.2
Clark, A.3
-
95
-
-
0033616575
-
Designing conditions for in vitro formation of amyloid proptofilaments and fibrils
-
Chiti F, Webster P, Taddei N, et al. Designing conditions for in vitro formation of amyloid proptofilaments and fibrils. Proc Natl Acad Sci USA 1999; 96: 3590-4.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3590-3594
-
-
Chiti, F.1
Webster, P.2
Taddei, N.3
-
96
-
-
0036845354
-
The behavior of polyamino acids reveals an inverse side chain effect in amyloid structure formation
-
Fandrich M, Dobson CM. The behavior of polyamino acids reveals an inverse side chain effect in amyloid structure formation. EMBO J 2002; 21: 5682-90.
-
(2002)
EMBO J
, vol.21
, pp. 5682-5690
-
-
Fandrich, M.1
Dobson, C.M.2
-
97
-
-
0344490335
-
Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition
-
Scheibel T, Parthasarathy R, Sawicki G, et al. Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition. Proc Natl Acad Sci USA 2003; 100(8): 4527-32.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.8
, pp. 4527-4532
-
-
Scheibel, T.1
Parthasarathy, R.2
Sawicki, G.3
-
99
-
-
84861954582
-
The in vitro inhibition effect of 2nm gold nanoparticles on non-enzymatic glycation of human serum albumin
-
Seneviratne C, Narayanan R, Liu W, Dain J. The in vitro inhibition effect of 2nm gold nanoparticles on non-enzymatic glycation of human serum albumin. Biochem Biophys Res Commun 2012; 422: 447-54.
-
(2012)
Biochem Biophys Res Commun
, vol.422
, pp. 447-454
-
-
Seneviratne, C.1
Narayanan, R.2
Liu, W.3
Dain, J.4
-
100
-
-
84863078915
-
Anti-glycation effect of gold nanoparticles on collagen
-
Kim J, Hong C, Koo Y, Choi H, Lee K. Anti-glycation effect of gold nanoparticles on collagen. Biol Pharm Bull 2012; 35: 260-4.
-
(2012)
Biol Pharm Bull
, vol.35
, pp. 260-264
-
-
Kim, J.1
Hong, C.2
Koo, Y.3
Choi, H.4
Lee, K.5
-
101
-
-
74449092465
-
The inhibition of advanced glycation end-products-induced retinal vascular permeability by silver nanoparticles
-
Sheikpranbabu S, Kalishwaralal K, Lee K, et al. The inhibition of advanced glycation end-products-induced retinal vascular permeability by silver nanoparticles. Biomaterials 2010; 31: 2260-71.
-
(2010)
Biomaterials
, vol.31
, pp. 2260-2271
-
-
Sheikpranbabu, S.1
Kalishwaralal, K.2
Lee, K.3
-
102
-
-
77953388318
-
Review, therapy for AD, how effective are current treatments?
-
Lanctot DL, Rajaram RD, Herrmann N. Review, therapy for AD, how effective are current treatments? Ther Adv Neurol 2009; 2: 163-80.
-
(2009)
Ther Adv Neurol
, vol.2
, pp. 163-180
-
-
Lanctot, D.L.1
Rajaram, R.D.2
Herrmann, N.3
-
103
-
-
34250744600
-
Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions
-
Doble BW, Woodgett JR. Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions. Cells Tissues Organs 2007; 185: 73-84.
-
(2007)
Cells Tissues Organs
, vol.185
, pp. 73-84
-
-
Doble, B.W.1
Woodgett, J.R.2
-
104
-
-
0038187674
-
GSK-3alpha regulates production of AD amyloid-beta peptides
-
Phiel CJ, Wilson CA, Lee VM, Klein PS. GSK-3alpha regulates production of AD amyloid-beta peptides. Nature 2003; 423: 435-9.
-
(2003)
Nature
, vol.423
, pp. 435-439
-
-
Phiel, C.J.1
Wilson, C.A.2
Lee, V.M.3
Klein, P.S.4
-
105
-
-
33750523825
-
Probing the physicochemical and structural requirements for glycogen synthase kinase-3alpha inhibition, 2D-QSAR for 3-anilino-4-phenylmaleimides
-
Sivaprakasam P, Xie A, Doerksen RJ. Probing the physicochemical and structural requirements for glycogen synthase kinase-3alpha inhibition, 2D-QSAR for 3-anilino-4-phenylmaleimides. Bioorg Med Chem 2006; 14: 8210-8.
-
(2006)
Bioorg Med Chem
, vol.14
, pp. 8210-8218
-
-
Sivaprakasam, P.1
Xie, A.2
Doerksen, R.J.3
-
106
-
-
3042558276
-
Glycogen synthase kinase 3: A drug target for CNS therapies
-
Bhat RV, Budd Haeberlein SL, Avila J. Glycogen synthase kinase 3: a drug target for CNS therapies. J Neurochem 2004; 89: 1313-7.
-
(2004)
J Neurochem
, vol.89
, pp. 1313-1317
-
-
Bhat, R.V.1
Budd, H.S.L.2
Avila, J.3
-
108
-
-
72449158360
-
Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer's disease model
-
Uabundit N, Wattanathorn J, Mucimapura S, Ingkaninan K. Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer's disease model. J Ethnopharmacol 2010; 127(1): 26-31.
-
(2010)
J Ethnopharmacol
, vol.127
, Issue.1
, pp. 26-31
-
-
Uabundit, N.1
Wattanathorn, J.2
Mucimapura, S.3
Ingkaninan, K.4
-
109
-
-
34249821079
-
Brain mitochondrial dysfunction as a link between AD and diabetes
-
Moreira PI, Santos MS, Seica R, Oliveira CR. Brain mitochondrial dysfunction as a link between AD and diabetes. J Neurol Sci 2007; 257: 206-14.
-
(2007)
J Neurol Sci
, vol.257
, pp. 206-214
-
-
Moreira, P.I.1
Santos, M.S.2
Seica, R.3
Oliveira, C.R.4
|