-
1
-
-
0032764016
-
Diabetes mellitus and the risk of dementia: the Rotterdam Study
-
Ott A, Stolk RP, van Harskamp F, Pols HA, Hofman A, Breteler MM. Diabetes mellitus and the risk of dementia: the Rotterdam Study. Neurology 1999; 53: 1937-42.
-
(1999)
Neurology
, vol.53
, pp. 1937-42
-
-
Ott, A.1
Stolk, R.P.2
van Harskamp, F.3
Pols, H.A.4
Hofman, A.5
Breteler, M.M.6
-
2
-
-
74049099554
-
The relationship between Alzheimer's disease and diabetes: type 3 diabetes?
-
Kroner Z. The relationship between Alzheimer's disease and diabetes: type 3 diabetes? Altern Med Rev 2009; 14: 373-9.
-
(2009)
Altern Med Rev
, vol.14
, pp. 373-9
-
-
Kroner, Z.1
-
3
-
-
36949038203
-
The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications
-
Jiang Q, Heneka M, Landreth GE. The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications. CNS Drugs 2008; 22: 1-14.
-
(2008)
CNS Drugs
, vol.22
, pp. 1-14
-
-
Jiang, Q.1
Heneka, M.2
Landreth, G.E.3
-
4
-
-
0021986560
-
Genetically obese Zucker rats have abnormally low brain insulin content
-
Baskin DG, Stein LJ, Ikeda H, Woods SC, Figlewicz DP, Porte D Jr, Greenwood MR, Dorsa DM. Genetically obese Zucker rats have abnormally low brain insulin content. Life Sci 1985; 36: 627-33.
-
(1985)
Life Sci
, vol.36
, pp. 627-33
-
-
Baskin, D.G.1
Stein, L.J.2
Ikeda, H.3
Woods, S.C.4
Figlewicz, D.P.5
Porte Jr, D.6
Greenwood, M.R.7
Dorsa, D.M.8
-
5
-
-
0031426348
-
Effect of diabetes mellitus on the permeability of the blood-brain barrier to insulin
-
Banks WA, Jaspan JB, Kastin AJ. Effect of diabetes mellitus on the permeability of the blood-brain barrier to insulin. Peptides 1997; 18: 1577-84.
-
(1997)
Peptides
, vol.18
, pp. 1577-84
-
-
Banks, W.A.1
Jaspan, J.B.2
Kastin, A.J.3
-
6
-
-
0033857975
-
Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs
-
Kaiyala KJ, Prigeon RL, Kahn SE, Woods SC, Schwartz MW. Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs. Diabetes 2000; 49: 1525-33.
-
(2000)
Diabetes
, vol.49
, pp. 1525-33
-
-
Kaiyala, K.J.1
Prigeon, R.L.2
Kahn, S.E.3
Woods, S.C.4
Schwartz, M.W.5
-
7
-
-
15444339756
-
Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease
-
Frolich L, Blum-Degen D, Bernstein HG, Engelsberger S, Humrich J, Laufer S, Muschner D, Thalheimer A, Turk A, Hoyer S, Zochling R, Boissl KW, Jellinger K, Riederer P. Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease. J Neural Transm 1998; 105: 423-38.
-
(1998)
J Neural Transm
, vol.105
, pp. 423-38
-
-
Frolich, L.1
Blum-Degen, D.2
Bernstein, H.G.3
Engelsberger, S.4
Humrich, J.5
Laufer, S.6
Muschner, D.7
Thalheimer, A.8
Turk, A.9
Hoyer, S.10
Zochling, R.11
Boissl, K.W.12
Jellinger, K.13
Riederer, P.14
-
8
-
-
15244351255
-
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes?
-
Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR, de la Monte SM. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes? J Alzheimers Dis 2005; 7: 63-80.
-
(2005)
J Alzheimers Dis
, vol.7
, pp. 63-80
-
-
Steen, E.1
Terry, B.M.2
Rivera, E.J.3
Cannon, J.L.4
Neely, T.R.5
Tavares, R.6
Xu, X.J.7
Wands, J.R.8
de la Monte, S.M.9
-
9
-
-
34147173277
-
Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment
-
Craft S. Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res 2007; 4: 147-52.
-
(2007)
Curr Alzheimer Res
, vol.4
, pp. 147-52
-
-
Craft, S.1
-
10
-
-
77951028451
-
Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes
-
Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R. Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes. Proc Natl Acad Sci USA 2010; 107: 7036-41.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 7036-41
-
-
Takeda, S.1
Sato, N.2
Uchio-Yamada, K.3
Sawada, K.4
Kunieda, T.5
Takeuchi, D.6
Kurinami, H.7
Shinohara, M.8
Rakugi, H.9
Morishita, R.10
-
11
-
-
79251601839
-
-
National Institute of Diabetes and Digestive and Kidney Diseases. Available at (last accessed 18 August 2010).
-
National Institute of Diabetes and Digestive and Kidney Diseases. Available at (last accessed 18 August 2010).
-
-
-
-
12
-
-
34547667389
-
Pre-diabetes: clinical relevance and therapeutic approach
-
Pratley RE, Matfin G. Pre-diabetes: clinical relevance and therapeutic approach. Br J Diabetes Vasc Dis 2007; 7: 120-9.
-
(2007)
Br J Diabetes Vasc Dis
, vol.7
, pp. 120-9
-
-
Pratley, R.E.1
Matfin, G.2
-
13
-
-
79251633416
-
-
Centers for Disease Control and Prevention. National diabetes fact sheet: general information and national estimates on diabetes in the United States. Available at (last accessed 18 August 2010).
-
Centers for Disease Control and Prevention. National diabetes fact sheet: general information and national estimates on diabetes in the United States. 2007. Available at (last accessed 18 August 2010).
-
(2007)
-
-
-
14
-
-
0037061867
-
Clinical practice. Nephropathy in patients with type 2 diabetes
-
Remuzzi G, Schieppati A, Ruggenenti P. Clinical practice. Nephropathy in patients with type 2 diabetes. N Engl J Med 2002; 346: 1145-51.
-
(2002)
N Engl J Med
, vol.346
, pp. 1145-51
-
-
Remuzzi, G.1
Schieppati, A.2
Ruggenenti, P.3
-
15
-
-
75149182840
-
Depression and advanced complications of diabetes: a prospective cohort study
-
Lin EH, Rutter CM, Katon W, Heckbert SR, Ciechanowski P, Oliver MM, Ludman EJ, Young BA, Williams LH, McCulloch DK, Von Korff M. Depression and advanced complications of diabetes: a prospective cohort study. Diabetes Care 2010; 33: 264-9.
-
(2010)
Diabetes Care
, vol.33
, pp. 264-9
-
-
Lin, E.H.1
Rutter, C.M.2
Katon, W.3
Heckbert, S.R.4
Ciechanowski, P.5
Oliver, M.M.6
Ludman, E.J.7
Young, B.A.8
Williams, L.H.9
McCulloch, D.K.10
Von Korff, M.11
-
16
-
-
62349104344
-
Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study
-
Look AHEAD Study Group
-
Jakicic JM, Jaramillo SA, Balasubramanyam A, Bancroft B, Curtis JM, Mathews A, Pereira M, Regensteiner JG, Ribisl PM, Look AHEAD Study Group. Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study. Int J Obes (Lond) 2009; 33: 305-16.
-
(2009)
Int J Obes (Lond)
, vol.33
, pp. 305-16
-
-
Jakicic, J.M.1
Jaramillo, S.A.2
Balasubramanyam, A.3
Bancroft, B.4
Curtis, J.M.5
Mathews, A.6
Pereira, M.7
Regensteiner, J.G.8
Ribisl, P.M.9
-
17
-
-
65649119680
-
Lifestyle risk factors and new-onset diabetes mellitus in older adults: the cardiovascular health study
-
Mozaffarian D, Kamineni A, Carnethon M, Djousse L, Mukamal KJ, Siscovick D. Lifestyle risk factors and new-onset diabetes mellitus in older adults: the cardiovascular health study. Arch Intern Med 2009; 169: 798-807.
-
(2009)
Arch Intern Med
, vol.169
, pp. 798-807
-
-
Mozaffarian, D.1
Kamineni, A.2
Carnethon, M.3
Djousse, L.4
Mukamal, K.J.5
Siscovick, D.6
-
18
-
-
33846572868
-
Glycated hemoglobin and risk of stroke in people without known diabetes in the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study: a threshold relationship?
-
Myint PK, Sinha S, Wareham NJ, Bingham SA, Luben RN, Welch AA, Khaw KT. Glycated hemoglobin and risk of stroke in people without known diabetes in the European Prospective Investigation into Cancer (EPIC)-Norfolk prospective population study: a threshold relationship? Stroke 2007; 38: 271-5.
-
(2007)
Stroke
, vol.38
, pp. 271-5
-
-
Myint, P.K.1
Sinha, S.2
Wareham, N.J.3
Bingham, S.A.4
Luben, R.N.5
Welch, A.A.6
Khaw, K.T.7
-
19
-
-
0030890905
-
Central nervous system complications of diabetes mellitus - a perspective from the blood-brain barrier
-
Mooradian AD. Central nervous system complications of diabetes mellitus - a perspective from the blood-brain barrier. Brain Res Brain Res Rev 1997; 23: 210-18.
-
(1997)
Brain Res Brain Res Rev
, vol.23
, pp. 210-18
-
-
Mooradian, A.D.1
-
20
-
-
0028856460
-
An English translation of Alzheimer's 1907 paper 'Uber eine eigenartige Erkrankung der Hirnrinde'
-
Alzheimer A, Stelzmann RA, Schnitzlein HN, Murtagh FR. An English translation of Alzheimer's 1907 paper 'Uber eine eigenartige Erkrankung der Hirnrinde'. Clin Anat 1995; 8: 429-43.
-
(1995)
Clin Anat
, vol.8
, pp. 429-43
-
-
Alzheimer, A.1
Stelzmann, R.A.2
Schnitzlein, H.N.3
Murtagh, F.R.4
-
21
-
-
77949336151
-
2010 Alzheimer's disease facts and figures
-
Alzheimer's Association.
-
Alzheimer's Association. 2010 Alzheimer's disease facts and figures. Alzheimers Dement 2010; 6: 158-94.
-
(2010)
Alzheimers Dement
, vol.6
, pp. 158-94
-
-
-
22
-
-
0035987489
-
Potential novel targets for Alzheimer pharmacotherapy: I. secretases
-
Maiorini AF, Gaunt MJ, Jacobsen TM, McKay AE, Waldman LD, Raffa RB. Potential novel targets for Alzheimer pharmacotherapy: I. secretases. J Clin Pharm Ther 2002; 27: 169-83.
-
(2002)
J Clin Pharm Ther
, vol.27
, pp. 169-83
-
-
Maiorini, A.F.1
Gaunt, M.J.2
Jacobsen, T.M.3
McKay, A.E.4
Waldman, L.D.5
Raffa, R.B.6
-
23
-
-
0003652388
-
DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders
-
American Psychiatric Association., 4th edn, text revision. Washington, DC: American Psychiatric Association,
-
American Psychiatric Association. DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders, 4th edn, text revision. Washington, DC: American Psychiatric Association, 2000.
-
(2000)
-
-
-
24
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002; 416: 535-9.
-
(2002)
Nature
, vol.416
, pp. 535-9
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
Rowan, M.J.7
Selkoe, D.J.8
-
25
-
-
0023037536
-
Isolation and partial characterization of neurofibrillary tangles and amyloid plaque core in Alzheimer's disease: immunohistological studies
-
Gorevic PD, Goni F, Pons-Estel B, Alvarez F, Peress NS, Frangione B. Isolation and partial characterization of neurofibrillary tangles and amyloid plaque core in Alzheimer's disease: immunohistological studies. J Neuropathol Exp Neurol 1986; 45: 647-64.
-
(1986)
J Neuropathol Exp Neurol
, vol.45
, pp. 647-64
-
-
Gorevic, P.D.1
Goni, F.2
Pons-Estel, B.3
Alvarez, F.4
Peress, N.S.5
Frangione, B.6
-
26
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 1986; 83: 4913-17.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 4913-17
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
27
-
-
0009364134
-
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease
-
Kosik KS, Joachim CL, Selkoe DJ. Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci USA 1986; 83: 4044-8.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 4044-8
-
-
Kosik, K.S.1
Joachim, C.L.2
Selkoe, D.J.3
-
28
-
-
0035927426
-
Secretase targets for Alzheimer's disease: identification and therapeutic potential
-
Wolfe MS. Secretase targets for Alzheimer's disease: identification and therapeutic potential. J Med Chem 2001; 44: 2039-60.
-
(2001)
J Med Chem
, vol.44
, pp. 2039-60
-
-
Wolfe, M.S.1
-
29
-
-
0033595202
-
APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome
-
Lai F, Kammann E, Rebeck GW, Anderson A, Chen Y, Nixon RA. APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome. Neurology 1999; 53: 331-6.
-
(1999)
Neurology
, vol.53
, pp. 331-6
-
-
Lai, F.1
Kammann, E.2
Rebeck, G.W.3
Anderson, A.4
Chen, Y.5
Nixon, R.A.6
-
30
-
-
0023133252
-
Apolipoprotein E isoform phenotyping methodology and population frequency with identification of apoE1 and apoE5 isoforms
-
Ordovas JM, Litwack-Klein L, Wilson PW, Schaefer MM, Schaefer EJ. Apolipoprotein E isoform phenotyping methodology and population frequency with identification of apoE1 and apoE5 isoforms. J Lipid Res 1987; 28: 371-80.
-
(1987)
J Lipid Res
, vol.28
, pp. 371-80
-
-
Ordovas, J.M.1
Litwack-Klein, L.2
Wilson, P.W.3
Schaefer, M.M.4
Schaefer, E.J.5
-
31
-
-
0009682659
-
Candle and Darkness: Current Research in Alzheimer's Disease
-
Chicago: Bonus Books Inc,
-
Rogers J. Candle and Darkness: Current Research in Alzheimer's Disease. Chicago: Bonus Books Inc, 1998.
-
(1998)
-
-
Rogers, J.1
-
32
-
-
0031792640
-
Environmental differences in twin pairs discordant for Alzheimer's disease
-
Raiha I, Kaprio J, Koskenvuo M, Rajala T, Sourander L. Environmental differences in twin pairs discordant for Alzheimer's disease. J Neurol Neurosurg Psychiatry 1998; 65: 785-7.
-
(1998)
J Neurol Neurosurg Psychiatry
, vol.65
, pp. 785-7
-
-
Raiha, I.1
Kaprio, J.2
Koskenvuo, M.3
Rajala, T.4
Sourander, L.5
-
33
-
-
26444463825
-
Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
-
Kivipelto M, Ngandu T, Fratiglioni L, Viitanen M, Kareholt I, Winblad B, Helkala EL, Tuomilehto J, Soininen H, Nissinen A. Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol 2005; 62: 1556-60.
-
(2005)
Arch Neurol
, vol.62
, pp. 1556-60
-
-
Kivipelto, M.1
Ngandu, T.2
Fratiglioni, L.3
Viitanen, M.4
Kareholt, I.5
Winblad, B.6
Helkala, E.L.7
Tuomilehto, J.8
Soininen, H.9
Nissinen, A.10
-
34
-
-
0028080315
-
The Canadian Study of Health and Aging: risk factors for Alzheimer's disease in Canada
-
Anonymous.
-
Anonymous. The Canadian Study of Health and Aging: risk factors for Alzheimer's disease in Canada. Neurology 1994; 44: 2073-80.
-
(1994)
Neurology
, vol.44
, pp. 2073-80
-
-
-
35
-
-
0042023711
-
Alzheimer disease in the US population: prevalence estimates using the 2000 census
-
Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol 2003; 60: 1119-22.
-
(2003)
Arch Neurol
, vol.60
, pp. 1119-22
-
-
Hebert, L.E.1
Scherr, P.A.2
Bienias, J.L.3
Bennett, D.A.4
Evans, D.A.5
-
36
-
-
0036845531
-
Dementia and Alzheimer's disease incidence: a prospective cohort study
-
Kukull WA, Higdon R, Bowen JD, McCormick WC, Teri L, Shellenberg GD, van Belle G. Dementia and Alzheimer's disease incidence: a prospective cohort study. Arch Neurol 2002; 59: 1737-46.
-
(2002)
Arch Neurol
, vol.59
, pp. 1737-46
-
-
Kukull, W.A.1
Higdon, R.2
Bowen, J.D.3
McCormick, W.C.4
Teri, L.5
Shellenberg, G.D.6
van Belle, G.7
-
37
-
-
20844458951
-
Earlier onset of Alzheimer disease symptoms in Latino individuals compared with Anglo individuals
-
Clark CM, DeCarli C, Mungas D, Chui HI, Higdon R, Nunez J, Fernandez H, Negron M, Manly J, Ferris S, Perez A, Torres M, Ewbank D, Glosser G, van Belle G. Earlier onset of Alzheimer disease symptoms in Latino individuals compared with Anglo individuals. Arch Neurol 2005; 62: 774-8.
-
(2005)
Arch Neurol
, vol.62
, pp. 774-8
-
-
Clark, C.M.1
DeCarli, C.2
Mungas, D.3
Chui, H.I.4
Higdon, R.5
Nunez, J.6
Fernandez, H.7
Negron, M.8
Manly, J.9
Ferris, S.10
Perez, A.11
Torres, M.12
Ewbank, D.13
Glosser, G.14
van Belle, G.15
-
38
-
-
79251649603
-
Epidemiology of Alzheimer's disease: race effects, area variation, and clustering
-
Laditka JN, Cornman CB, Lane M, Porter CN, Davis DR. Epidemiology of Alzheimer's disease: race effects, area variation, and clustering. Neurobiol Aging 2004; 25: S392-S393.
-
(2004)
Neurobiol Aging
, vol.25
-
-
Laditka, J.N.1
Cornman, C.B.2
Lane, M.3
Porter, C.N.4
Davis, D.R.5
-
39
-
-
79251645594
-
Pathophysiology: A Pharmacotherapy Approach
-
4th edn, eds DiPiro JT, Talbert RL, Yee GC, Mazke GR, Wells BG, Posey LM. New York: Appleton & Lange.
-
Crimson ML, Eggert AE. Alzheimer's disease. In: Pathophysiology: A Pharmacotherapy Approach, 4th edn, eds DiPiro JT, Talbert RL, Yee GC, Mazke GR, Wells BG, Posey LM. New York: Appleton & Lange, 1999; 1077.
-
(1999)
Alzheimer's disease
, pp. 1077
-
-
Crimson, M.L.1
Eggert, A.E.2
-
40
-
-
1842487502
-
Survival after initial diagnosis of Alzheimer disease
-
Larson EB, Shadlen MF, Wang L, McCormick WC, Bowen JD, Teri L, Kukull WA. Survival after initial diagnosis of Alzheimer disease. Ann Intern Med 2004; 140: 501-9.
-
(2004)
Ann Intern Med
, vol.140
, pp. 501-9
-
-
Larson, E.B.1
Shadlen, M.F.2
Wang, L.3
McCormick, W.C.4
Bowen, J.D.5
Teri, L.6
Kukull, W.A.7
-
41
-
-
50349102777
-
Deaths: Preliminary Data for 2006
-
National Vital Statistics Report, 56. Hyattsville, MD: National Center for Health Statistics,
-
Heron MP, Hoyert DL, Xu J, Scott C, Tejada-Vera B. Deaths: Preliminary Data for 2006. National Vital Statistics Report, 56. Hyattsville, MD: National Center for Health Statistics, 2008.
-
(2008)
-
-
Heron, M.P.1
Hoyert, D.L.2
Xu, J.3
Scott, C.4
Tejada-Vera, B.5
-
42
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 1996; 2: 864-70.
-
(1996)
Nat Med
, vol.2
, pp. 864-70
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
Larson, E.11
Levy-Lahad, E.12
Viitanen, M.13
Peskind, E.14
Poorkaj, P.15
Schellenberg, G.16
Tanzi, R.17
Wasco, W.18
Lannfelt, L.19
Selkoe, D.20
Younkin, S.21
more..
-
43
-
-
0022633680
-
Conditions associated with Alzheimer's disease at death: case-control study
-
Chandra V, Bharucha NE, Schoenberg BS. Conditions associated with Alzheimer's disease at death: case-control study. Neurology 1986; 36: 209-11.
-
(1986)
Neurology
, vol.36
, pp. 209-11
-
-
Chandra, V.1
Bharucha, N.E.2
Schoenberg, B.S.3
-
44
-
-
77953388318
-
Review: therapy for Alzheimer's disease: how effective are current treatments?
-
Lanctot DL, Rajaram RD, Herrmann N. Review: therapy for Alzheimer's disease: how effective are current treatments? Ther Adv Neurol 2009; 2: 163-80.
-
(2009)
Ther Adv Neurol
, vol.2
, pp. 163-80
-
-
Lanctot, D.L.1
Rajaram, R.D.2
Herrmann, N.3
-
45
-
-
0037221379
-
The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment
-
Watson GS, Craft S. The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment. CNS Drugs 2003; 17: 27-45.
-
(2003)
CNS Drugs
, vol.17
, pp. 27-45
-
-
Watson, G.S.1
Craft, S.2
-
46
-
-
0002096610
-
Gilman and Goodman's the Pharmacological Basis of Therapeutics
-
9th edn, eds Hardman JG, Gilman AG, Limbird LE. New York: McGraw-Hill
-
Davis SN, Granner DK. Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas. In: Gilman and Goodman's the Pharmacological Basis of Therapeutics, 9th edn, eds Hardman JG, Gilman AG, Limbird LE. New York: McGraw-Hill, 1996; 1487-517.
-
(1996)
Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas
, pp. 1487-517
-
-
Davis, S.N.1
Granner, D.K.2
-
48
-
-
0018090354
-
Insulin receptors are widely distributed in the central nervous system of the rat
-
Havrankova J, Roth J, Brownstein M. Insulin receptors are widely distributed in the central nervous system of the rat. Nature 1978; 272: 827-9.
-
(1978)
Nature
, vol.272
, pp. 827-9
-
-
Havrankova, J.1
Roth, J.2
Brownstein, M.3
-
49
-
-
0034508636
-
Insulin receptors and insulin action in the nervous system
-
Freychet P. Insulin receptors and insulin action in the nervous system. Diabetes Metab Res Rev 2000; 16: 390-2.
-
(2000)
Diabetes Metab Res Rev
, vol.16
, pp. 390-2
-
-
Freychet, P.1
-
50
-
-
36448936053
-
Common pathological processes in Alzheimer disease and type 2 diabetes: a review
-
Li L, Holscher C. Common pathological processes in Alzheimer disease and type 2 diabetes: a review. Brain Res Rev 2007; 56: 384-402.
-
(2007)
Brain Res Rev
, vol.56
, pp. 384-402
-
-
Li, L.1
Holscher, C.2
-
51
-
-
33644553117
-
Increased cortical atrophy in patients with Alzheimer's disease and type 2 diabetes mellitus
-
Biessels GJ, De Leeuw FE, Lindeboom J, Barkhof F, Scheltens P. Increased cortical atrophy in patients with Alzheimer's disease and type 2 diabetes mellitus. J Neurol Neurosurg Psychiatry 2006; 77: 304-7.
-
(2006)
J Neurol Neurosurg Psychiatry
, vol.77
, pp. 304-7
-
-
Biessels, G.J.1
De Leeuw, F.E.2
Lindeboom, J.3
Barkhof, F.4
Scheltens, P.5
-
52
-
-
27844458139
-
Insulin and cholesterol pathways in neuronal function, memory and neurodegeneration
-
Nelson TJ, Alkon DI. Insulin and cholesterol pathways in neuronal function, memory and neurodegeneration. Biochem Soc Trans 2005; 33: 1033-6.
-
(2005)
Biochem Soc Trans
, vol.33
, pp. 1033-6
-
-
Nelson, T.J.1
Alkon, D.I.2
-
53
-
-
14044273751
-
Hippocampal synaptic modulation by the phosphotyrosine adapter protein AhcC/N-Shc via interaction with the NMDA receptor
-
Miyamoto Y, Chen L, Sato M, Sokabe M, Nabeshima T, Pawson T, Sakai R, Mori N. Hippocampal synaptic modulation by the phosphotyrosine adapter protein AhcC/N-Shc via interaction with the NMDA receptor. J Neurosci 2005; 16: 1826-35.
-
(2005)
J Neurosci
, vol.16
, pp. 1826-35
-
-
Miyamoto, Y.1
Chen, L.2
Sato, M.3
Sokabe, M.4
Nabeshima, T.5
Pawson, T.6
Sakai, R.7
Mori, N.8
-
54
-
-
33745215607
-
Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat
-
Horwood JM, Dufour F, Laroche S, Davis S. Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat. Eur J Neurosci 2006; 23: 3375-84.
-
(2006)
Eur J Neurosci
, vol.23
, pp. 3375-84
-
-
Horwood, J.M.1
Dufour, F.2
Laroche, S.3
Davis, S.4
-
55
-
-
24944532213
-
PI3 kinase signaling is required for retrieval and extinction of contextual memory
-
Chen X, Garelick MG, Wang H, Lil V, Athos J, Storm DR. PI3 kinase signaling is required for retrieval and extinction of contextual memory. Nat Neurosci 2005; 8: 925-31.
-
(2005)
Nat Neurosci
, vol.8
, pp. 925-31
-
-
Chen, X.1
Garelick, M.G.2
Wang, H.3
Lil, V.4
Athos, J.5
Storm, D.R.6
-
56
-
-
77951060396
-
PI3 kinase signaling is involved in Aβ-induced memory loss in Drosophila
-
Chiang HC, Wang L, Xie Z, Yau A, Zhong Y. PI3 kinase signaling is involved in Aβ-induced memory loss in Drosophila. Proc Natl Acad Sci USA 2010; 107: 7060-5.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 7060-5
-
-
Chiang, H.C.1
Wang, L.2
Xie, Z.3
Yau, A.4
Zhong, Y.5
-
58
-
-
0032740245
-
Endogenous nitric oxide synthesis: biological functions and pathophysiology
-
Bredt DS. Endogenous nitric oxide synthesis: biological functions and pathophysiology. Free Radic Res 1999; 31: 577-96.
-
(1999)
Free Radic Res
, vol.31
, pp. 577-96
-
-
Bredt, D.S.1
-
59
-
-
0030800192
-
A receptors to postsynaptic domains by insulin
-
A receptors to postsynaptic domains by insulin. Nature 1997; 388: 686-90.
-
(1997)
Nature
, vol.388
, pp. 686-90
-
-
Wan, Q.1
Xiong, Z.G.2
Man, H.Y.3
Ackerley, C.A.4
Braunton, J.5
Lu, W.Y.6
Becker, L.E.7
MacDonald, J.F.8
Wang, Y.T.9
-
60
-
-
0028418813
-
Mechanisms of hormone resistance: lessons from insulin-resistant patients
-
Taylor SI, Accili D, Haft CR, Hone J, Imai Y, Levy-Toledano R, Quon MJ, Suzuki Y, Wertheimer E. Mechanisms of hormone resistance: lessons from insulin-resistant patients. Acta Paediatr Suppl 1994; 399: 95-104.
-
(1994)
Acta Paediatr Suppl
, vol.399
, pp. 95-104
-
-
Taylor, S.I.1
Accili, D.2
Haft, C.R.3
Hone, J.4
Imai, Y.5
Levy-Toledano, R.6
Quon, M.J.7
Suzuki, Y.8
Wertheimer, E.9
-
61
-
-
0030047594
-
Insulin receptor mRNA in the substantia nigra in Parkinson's disease
-
Takahashi M, Yamada T, Tooyama I, Moroo I, Kimura H, Yamamoto T, Okada H. Insulin receptor mRNA in the substantia nigra in Parkinson's disease. Neurosci Lett 1996; 204: 201-4.
-
(1996)
Neurosci Lett
, vol.204
, pp. 201-4
-
-
Takahashi, M.1
Yamada, T.2
Tooyama, I.3
Moroo, I.4
Kimura, H.5
Yamamoto, T.6
Okada, H.7
-
62
-
-
0015521813
-
Increased frequency of diabetes mellitus in patients with Huntington's chorea
-
Podolsky S, Leopold NA, Sax DS. Increased frequency of diabetes mellitus in patients with Huntington's chorea. Lancet 1972; 1: 1356-8.
-
(1972)
Lancet
, vol.1
, pp. 1356-8
-
-
Podolsky, S.1
Leopold, N.A.2
Sax, D.S.3
-
63
-
-
0027126287
-
Retinoblastoma. For our eyes only
-
Harlow E. Retinoblastoma. For our eyes only. Nature 1992; 359: 270-1.
-
(1992)
Nature
, vol.359
, pp. 270-1
-
-
Harlow, E.1
-
64
-
-
1542365240
-
Migraine as a risk factor for subclinical brain lesions
-
Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD, Launer LJ. Migraine as a risk factor for subclinical brain lesions. JAMA 2004; 291: 427-34.
-
(2004)
JAMA
, vol.291
, pp. 427-34
-
-
Kruit, M.C.1
van Buchem, M.A.2
Hofman, P.A.3
Bakkers, J.T.4
Terwindt, G.M.5
Ferrari, M.D.6
Launer, L.J.7
-
66
-
-
4243226403
-
Receptors in the Developing Nervous System
-
eds Zagon IS, McLaughlin PJ. London: Chapman and Hall
-
Werner H, Roberts CTJ, Raizada MK, Bondy CA, Adamo M, Le Roith D. Developmental regulation of the insulin and insulin-like growth factor receptors in the central nervous system. In: Receptors in the Developing Nervous System, eds Zagon IS, McLaughlin PJ. London: Chapman and Hall, 1993; 109-27.
-
(1993)
Developmental regulation of the insulin and insulin-like growth factor receptors in the central nervous system
, pp. 109-27
-
-
Werner, H.1
Roberts, C.T.J.2
Raizada, M.K.3
Bondy, C.A.4
Adamo, M.5
Le Roith, D.6
-
67
-
-
0022510796
-
Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and limbic areas
-
Hill JM, Lesniak MA, Pert CB, Roth J. Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and limbic areas. Neuroscience 1986; 17: 1127-38.
-
(1986)
Neuroscience
, vol.17
, pp. 1127-38
-
-
Hill, J.M.1
Lesniak, M.A.2
Pert, C.B.3
Roth, J.4
-
68
-
-
0023271871
-
Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry
-
Werther GA, Hogg A, Oldfield BJ, McKinley MJ, Figdor R, Allen AM, Mendelsohn FA. Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry. Endocrinology 1987; 121: 1562-70.
-
(1987)
Endocrinology
, vol.121
, pp. 1562-70
-
-
Werther, G.A.1
Hogg, A.2
Oldfield, B.J.3
McKinley, M.J.4
Figdor, R.5
Allen, A.M.6
Mendelsohn, F.A.7
-
69
-
-
0025612094
-
Localization of insulin receptor mRNA in rat brain by in situ hybridization
-
Marks JL, Porte D Jr, Stahl WL, Baskin DG. Localization of insulin receptor mRNA in rat brain by in situ hybridization. Endocrinology 1990; 127: 3234-6.
-
(1990)
Endocrinology
, vol.127
, pp. 3234-6
-
-
Marks, J.L.1
Porte Jr, D.2
Stahl, W.L.3
Baskin, D.G.4
-
70
-
-
0031975390
-
Towards understanding the role of insulin in the brain: lessons from insulin-related signaling systems in the invertebrate brain
-
Smit AB, van Kesteren RE, Li KW, Van Minnen J, Spijker S, Van Heerikhuizen H, Geraerts WP. Towards understanding the role of insulin in the brain: lessons from insulin-related signaling systems in the invertebrate brain. Prog Neurobiol 1998; 54: 35-54.
-
(1998)
Prog Neurobiol
, vol.54
, pp. 35-54
-
-
Smit, A.B.1
van Kesteren, R.E.2
Li, K.W.3
Van Minnen, J.4
Spijker, S.5
Van Heerikhuizen, H.6
Geraerts, W.P.7
-
71
-
-
79251620883
-
The Protein Kinase FactsBook
-
Hardie G, Hanks S, authors, eds., London: Academic Press,
-
Hardie G, Hanks S, authors, eds. The Protein Kinase FactsBook, Vol. 1. London: Academic Press, 1995.
-
(1995)
, vol.1
-
-
-
72
-
-
79251620883
-
The Protein Kinase FactsBook
-
Hardie G, Hanks S, authors, eds., London: Academic Press,
-
Hardie G, Hanks S, authors, eds. The Protein Kinase FactsBook, Vol. 2. London: Academic Press, 1995.
-
(1995)
, vol.2
-
-
-
73
-
-
0018926038
-
Interactions of insulin-like growth factors I and II and multiplication-stimulating activity with receptors and serum carrier proteins
-
Rechler MM, Zapf J, Nissley SP, Froesch ER, Moses AC, Podskalny JM, Schilling EE, Humbel RE. Interactions of insulin-like growth factors I and II and multiplication-stimulating activity with receptors and serum carrier proteins. Endocrinology 1980; 107: 1451-9.
-
(1980)
Endocrinology
, vol.107
, pp. 1451-9
-
-
Rechler, M.M.1
Zapf, J.2
Nissley, S.P.3
Froesch, E.R.4
Moses, A.C.5
Podskalny, J.M.6
Schilling, E.E.7
Humbel, R.E.8
-
74
-
-
0024347261
-
Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization
-
Adem A, Jossan SS, d'Argy R, Gillberg PG, Nordberg A, Winbald B, Sara V. Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization. Brain Res 1989; 503: 299-303.
-
(1989)
Brain Res
, vol.503
, pp. 299-303
-
-
Adem, A.1
Jossan, S.S.2
d'Argy, R.3
Gillberg, P.G.4
Nordberg, A.5
Winbald, B.6
Sara, V.7
-
75
-
-
33644591150
-
Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine
-
Rivera EJ, Goldin A, Fulmer N, Tavares R, Wands JR, de la Monte SM. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J Alzheimers Dis 2005; 8: 247-68.
-
(2005)
J Alzheimers Dis
, vol.8
, pp. 247-68
-
-
Rivera, E.J.1
Goldin, A.2
Fulmer, N.3
Tavares, R.4
Wands, J.R.5
de la Monte, S.M.6
-
76
-
-
0036581966
-
Diabetic dyslipidemia
-
Taskinen M. Diabetic dyslipidemia. Atheroscler Suppl 2002; 3: 47-51.
-
(2002)
Atheroscler Suppl
, vol.3
, pp. 47-51
-
-
Taskinen, M.1
-
79
-
-
33746932145
-
Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils
-
Hatters DM, Zhong N, Rutenber E, Weisgraber KH. Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils. J Mol Biol 2006; 361: 932-44.
-
(2006)
J Mol Biol
, vol.361
, pp. 932-44
-
-
Hatters, D.M.1
Zhong, N.2
Rutenber, E.3
Weisgraber, K.H.4
-
80
-
-
70450219539
-
Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease
-
Martins IJ, Berger T, Sharman MJ, Verdile G, Fuller SJ, Martins RN. Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease. J Neurochem 2009; 111: 1275-308.
-
(2009)
J Neurochem
, vol.111
, pp. 1275-308
-
-
Martins, I.J.1
Berger, T.2
Sharman, M.J.3
Verdile, G.4
Fuller, S.J.5
Martins, R.N.6
-
81
-
-
30044441879
-
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease
-
Hirsch-Reinshagen V, Maia LF, Burgess BL, Blain JF, Naus KE, McIsaac SA, Parkinson PF, Chan JY, Tansley GH, Hayden MR, Poirier J, Van Nostrand W, Wellington CL. The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease. J Biol Chem 2005; 280: 43243-56.
-
(2005)
J Biol Chem
, vol.280
, pp. 43243-56
-
-
Hirsch-Reinshagen, V.1
Maia, L.F.2
Burgess, B.L.3
Blain, J.F.4
Naus, K.E.5
McIsaac, S.A.6
Parkinson, P.F.7
Chan, J.Y.8
Tansley, G.H.9
Hayden, M.R.10
Poirier, J.11
Van Nostrand, W.12
Wellington, C.L.13
-
82
-
-
70449564488
-
Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease
-
Fernandez-Gamba A, Leal MC, Morelli L, Castano EM. Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease. Curr Pharm Des 2009; 15: 3644-55.
-
(2009)
Curr Pharm Des
, vol.15
, pp. 3644-55
-
-
Fernandez-Gamba, A.1
Leal, M.C.2
Morelli, L.3
Castano, E.M.4
-
83
-
-
4143134071
-
Insulin-degrading enzyme, apolipoprotein E, and Alzheimer's disease
-
Edland SD. Insulin-degrading enzyme, apolipoprotein E, and Alzheimer's disease. J Mol Neurosci 2004; 23: 213-17.
-
(2004)
J Mol Neurosci
, vol.23
, pp. 213-17
-
-
Edland, S.D.1
-
84
-
-
70349505965
-
Role of the JNK-interacting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes
-
Beeler N, Riederer BM, Waeber G, Abderrahmani A. Role of the JNK-interacting protein 1/islet brain 1 in cell degeneration in Alzheimer disease and diabetes. Brain Res Bull 2009; 80: 274-81.
-
(2009)
Brain Res Bull
, vol.80
, pp. 274-81
-
-
Beeler, N.1
Riederer, B.M.2
Waeber, G.3
Abderrahmani, A.4
-
85
-
-
0025302287
-
Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells
-
Kahn SE, D'Alessio DA, Schwartz MW, Fujimoto WY, Ensinck JW, Taborsky GJ Jr, Porte D Jr. Evidence of cosecretion of islet amyloid polypeptide and insulin by beta-cells. Diabetes 1990; 39: 634-8.
-
(1990)
Diabetes
, vol.39
, pp. 634-8
-
-
Kahn, S.E.1
D'Alessio, D.A.2
Schwartz, M.W.3
Fujimoto, W.Y.4
Ensinck, J.W.5
Taborsky Jr, G.J.6
Porte Jr, D.7
-
86
-
-
0029901739
-
Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide
-
Janson J, Soeller WC, Roche PC, Nelson RT, Torchia AJ, Kreutter DK, Butler PC. Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide. Proc Natl Acad Sci USA 1996; 93: 7283-8.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 7283-8
-
-
Janson, J.1
Soeller, W.C.2
Roche, P.C.3
Nelson, R.T.4
Torchia, A.J.5
Kreutter, D.K.6
Butler, P.C.7
-
87
-
-
77954955774
-
Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes
-
Miklossy J, Qing H, Radenovic A, Kis A, Vileno B, Laszlo F, Miller L, Martins RN, Waeber G, Mooser V, Bosman F, Khalili K, Darbinian N, McGeer PL. Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiol Aging 2010; 31: 1503-15.
-
(2010)
Neurobiol Aging
, vol.31
, pp. 1503-15
-
-
Miklossy, J.1
Qing, H.2
Radenovic, A.3
Kis, A.4
Vileno, B.5
Laszlo, F.6
Miller, L.7
Martins, R.N.8
Waeber, G.9
Mooser, V.10
Bosman, F.11
Khalili, K.12
Darbinian, N.13
McGeer, P.L.14
-
88
-
-
0036227542
-
Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: the Honolulu-Asia Aging Study
-
Peila R, Rodriguez BL, Launer LJ. Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: the Honolulu-Asia Aging Study. Diabetes 2002; 51: 1256-62.
-
(2002)
Diabetes
, vol.51
, pp. 1256-62
-
-
Peila, R.1
Rodriguez, B.L.2
Launer, L.J.3
-
89
-
-
0842309993
-
Increased risk of type 2 diabetes in Alzheimer disease
-
Janson J, Laedtke T, Parisi JE, O'Brien P, Petersen RC, Butler PC. Increased risk of type 2 diabetes in Alzheimer disease. Diabetes 2004; 53: 474-81.
-
(2004)
Diabetes
, vol.53
, pp. 474-81
-
-
Janson, J.1
Laedtke, T.2
Parisi, J.E.3
O'Brien, P.4
Petersen, R.C.5
Butler, P.C.6
-
90
-
-
0036548070
-
gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?
-
Sisodia SS, St George-Hyslop PH. gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Nat Rev Neurosci 2002; 3: 281-90.
-
(2002)
Nat Rev Neurosci
, vol.3
, pp. 281-90
-
-
Sisodia, S.S.1
St George-Hyslop, P.H.2
-
91
-
-
27844498075
-
Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies
-
Holscher C. Development of beta-amyloid-induced neurodegeneration in Alzheimer's disease and novel neuroprotective strategies. Rev Neurosci 2005; 16: 181-212.
-
(2005)
Rev Neurosci
, vol.16
, pp. 181-212
-
-
Holscher, C.1
-
92
-
-
4644360412
-
MARKing tau for tangles and toxicity
-
Drewes G. MARKing tau for tangles and toxicity. Trends Biochem Sci 2004; 29: 548-55.
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 548-55
-
-
Drewes, G.1
-
93
-
-
34250744600
-
Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions
-
Doble BW, Woodgett JR. Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions. Cells Tissues Organs 2007; 185: 73-84.
-
(2007)
Cells Tissues Organs
, vol.185
, pp. 73-84
-
-
Doble, B.W.1
Woodgett, J.R.2
-
94
-
-
0038187674
-
GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides
-
Phiel CJ, Wilson CA, Lee VM, Klein PS. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature 2003; 423: 435-9.
-
(2003)
Nature
, vol.423
, pp. 435-9
-
-
Phiel, C.J.1
Wilson, C.A.2
Lee, V.M.3
Klein, P.S.4
-
95
-
-
33750523825
-
Probing the physicochemical and structural requirements for glycogen synthase kinase-3alpha inhibition: 2D-QSAR for 3-anilino-4-phenylmaleimides
-
Sivaprakasam P, Xie A, Doerksen RJ. Probing the physicochemical and structural requirements for glycogen synthase kinase-3alpha inhibition: 2D-QSAR for 3-anilino-4-phenylmaleimides. Bioorg Med Chem 2006; 14: 8210-18.
-
(2006)
Bioorg Med Chem
, vol.14
, pp. 8210-18
-
-
Sivaprakasam, P.1
Xie, A.2
Doerksen, R.J.3
-
96
-
-
3042558276
-
Glycogen synthase kinase 3: a drug target for CNS therapies
-
Bhat RV, Budd Haeberlein SL, Avila J. Glycogen synthase kinase 3: a drug target for CNS therapies. J Neurochem 2004; 89: 1313-17.
-
(2004)
J Neurochem
, vol.89
, pp. 1313-17
-
-
Bhat, R.V.1
Budd Haeberlein, S.L.2
Avila, J.3
-
98
-
-
0034727889
-
JNK activation is associated with intracellular beta-amyloid accumulation
-
Shoji M, Iwakami N, Takeuchi S, Waragai M, Suzuki M, Kanazawa I, Lippa CF, Ono S, Okazawa H. JNK activation is associated with intracellular beta-amyloid accumulation. Brain Res Mol Brain Res 2000; 85: 221-33.
-
(2000)
Brain Res Mol Brain Res
, vol.85
, pp. 221-33
-
-
Shoji, M.1
Iwakami, N.2
Takeuchi, S.3
Waragai, M.4
Suzuki, M.5
Kanazawa, I.6
Lippa, C.F.7
Ono, S.8
Okazawa, H.9
-
99
-
-
36749066101
-
Oxidative stress and the JNK pathway are involved in the development of type 1 and type 2 diabetes
-
Kaneto H, Matsuoka TA, Katakami N, Kawamori D, Miyatsuka T, Yoshiuchi K, Yasuda T, Sakamoto K, Yamasaki Y, Matsuhisa M. Oxidative stress and the JNK pathway are involved in the development of type 1 and type 2 diabetes. Curr Mol Med 2007; 7: 674-86.
-
(2007)
Curr Mol Med
, vol.7
, pp. 674-86
-
-
Kaneto, H.1
Matsuoka, T.A.2
Katakami, N.3
Kawamori, D.4
Miyatsuka, T.5
Yoshiuchi, K.6
Yasuda, T.7
Sakamoto, K.8
Yamasaki, Y.9
Matsuhisa, M.10
-
100
-
-
0033151572
-
Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation
-
Ando K, Oishi M, Takeda S, Iijima K, Isohara T, Nairn AC, Kirino Y, Greengard P, Suzuki T. Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation. J Neurosci 1999; 19: 4421-7.
-
(1999)
J Neurosci
, vol.19
, pp. 4421-7
-
-
Ando, K.1
Oishi, M.2
Takeda, S.3
Iijima, K.4
Isohara, T.5
Nairn, A.C.6
Kirino, Y.7
Greengard, P.8
Suzuki, T.9
-
102
-
-
34249776342
-
c-Jun phosphorylation in Alzheimer disease
-
Thakur A, Wang X, Siedlak SL, Perry G, Smith MA, Zhu X. c-Jun phosphorylation in Alzheimer disease. J Neurosci Res 2007; 85: 1668-73.
-
(2007)
J Neurosci Res
, vol.85
, pp. 1668-73
-
-
Thakur, A.1
Wang, X.2
Siedlak, S.L.3
Perry, G.4
Smith, M.A.5
Zhu, X.6
-
103
-
-
0034855391
-
Markers of inflammation and cellular adhesion molecules in relation to insulin resistance in nondiabetic elderly: the Rotterdam study
-
Hak AE, Pols HA, Stehouwer CD, Meijer J, Kiliaan AJ, Hofman A, Breteler MM, Witteman JC. Markers of inflammation and cellular adhesion molecules in relation to insulin resistance in nondiabetic elderly: the Rotterdam study. J Clin Endocrinol Metab 2001; 86: 4398-405.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 4398-405
-
-
Hak, A.E.1
Pols, H.A.2
Stehouwer, C.D.3
Meijer, J.4
Kiliaan, A.J.5
Hofman, A.6
Breteler, M.M.7
Witteman, J.C.8
-
104
-
-
0037212882
-
Strong decrease of high sensitivity C-reactive protein with high-dose atorvastatin in patients with type 2 diabetes mellitus
-
DALI-Study Group
-
van de Ree MA, Huisman MV, Princen HM, Meinders AE, Kluft C, DALI-Study Group. Strong decrease of high sensitivity C-reactive protein with high-dose atorvastatin in patients with type 2 diabetes mellitus. Atherosclerosis 2003; 166: 129-35.
-
(2003)
Atherosclerosis
, vol.166
, pp. 129-35
-
-
van de Ree, M.A.1
Huisman, M.V.2
Princen, H.M.3
Meinders, A.E.4
Kluft, C.5
-
105
-
-
0346880504
-
Inflammatory pathways and insulin action
-
Hotamisligil GS. Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord 2003; 27 (Suppl. 3): S53-5.
-
(2003)
Int J Obes Relat Metab Disord
, vol.27
, Issue.3 SUPPL.
-
-
Hotamisligil, G.S.1
-
106
-
-
0030731621
-
NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X
-
Pickup JC, Mattock MB, Chusney GD, Burt D. NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 1997; 40: 1286-92.
-
(1997)
Diabetologia
, vol.40
, pp. 1286-92
-
-
Pickup, J.C.1
Mattock, M.B.2
Chusney, G.D.3
Burt, D.4
-
107
-
-
0347930372
-
Genetics, lifestyle and the roles of amyloid beta and oxidative stress in Alzheimer's disease
-
Veurink G, Fuller SJ, Atwood CS, Martins RN. Genetics, lifestyle and the roles of amyloid beta and oxidative stress in Alzheimer's disease. Ann Hum Biol 2003; 30: 639-67.
-
(2003)
Ann Hum Biol
, vol.30
, pp. 639-67
-
-
Veurink, G.1
Fuller, S.J.2
Atwood, C.S.3
Martins, R.N.4
-
109
-
-
0034507950
-
A perspective on inflammation in Alzheimer's disease
-
Rogers J, Shen Y. A perspective on inflammation in Alzheimer's disease. Ann N Y Acad Sci 2000; 924: 132-5.
-
(2000)
Ann N Y Acad Sci
, vol.924
, pp. 132-5
-
-
Rogers, J.1
Shen, Y.2
-
110
-
-
0035691035
-
Modeling microglial activation in Alzheimer's disease with human postmortem microglial cultures
-
Lue LF, Walker DG, Rogers J. Modeling microglial activation in Alzheimer's disease with human postmortem microglial cultures. Neurobiol Aging 2001; 22: 945-56.
-
(2001)
Neurobiol Aging
, vol.22
, pp. 945-56
-
-
Lue, L.F.1
Walker, D.G.2
Rogers, J.3
-
111
-
-
0030014561
-
The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease
-
Hull M, Strauss S, Berger M, Volk B, Bauer J. The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease. Behav Brain Res 1996; 78: 37-41.
-
(1996)
Behav Brain Res
, vol.78
, pp. 37-41
-
-
Hull, M.1
Strauss, S.2
Berger, M.3
Volk, B.4
Bauer, J.5
-
112
-
-
0035150373
-
Intra vitam lumbar and post mortem ventricular cerebrospinal fluid immunoreactive interleukin-6 in Alzheimer's disease patients
-
Rosler N, Wichart I, Jellinger KA. Intra vitam lumbar and post mortem ventricular cerebrospinal fluid immunoreactive interleukin-6 in Alzheimer's disease patients. Acta Neurol Scand 2001; 103: 126-30.
-
(2001)
Acta Neurol Scand
, vol.103
, pp. 126-30
-
-
Rosler, N.1
Wichart, I.2
Jellinger, K.A.3
-
113
-
-
0036321773
-
Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study
-
Schmidt R, Schmidt H, Curb JD, Masaki K, White LR, Launer LJ. Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study. Ann Neurol 2002; 52: 168-74.
-
(2002)
Ann Neurol
, vol.52
, pp. 168-74
-
-
Schmidt, R.1
Schmidt, H.2
Curb, J.D.3
Masaki, K.4
White, L.R.5
Launer, L.J.6
-
114
-
-
2442533101
-
Inflammatory proteins in plasma and the risk of dementia: the Rotterdam study
-
Engelhart MJ, Geerlings MI, Meijer J, Kiliaan A, Ruitenberg A, van Swieten JC, Stijnen T, Hofman A, Witteman JC, Breteler MM. Inflammatory proteins in plasma and the risk of dementia: the Rotterdam study. Arch Neurol 2004; 61: 668-72.
-
(2004)
Arch Neurol
, vol.61
, pp. 668-72
-
-
Engelhart, M.J.1
Geerlings, M.I.2
Meijer, J.3
Kiliaan, A.4
Ruitenberg, A.5
van Swieten, J.C.6
Stijnen, T.7
Hofman, A.8
Witteman, J.C.9
Breteler, M.M.10
-
115
-
-
0034643832
-
Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: the Cache County study
-
Anthony JC, Breitner JC, Zandi PP, Meyer MR, Jurasova I, Norton MC, Stone SV. Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists: the Cache County study. Neurology 2000; 54: 2066-71.
-
(2000)
Neurology
, vol.54
, pp. 2066-71
-
-
Anthony, J.C.1
Breitner, J.C.2
Zandi, P.P.3
Meyer, M.R.4
Jurasova, I.5
Norton, M.C.6
Stone, S.V.7
-
116
-
-
0033751840
-
Anti-inflammatory drugs protect against Alzheimer disease at low doses
-
Broe GA, Grayson DA, Creasey HM, Waite LM, Casey BJ, Bennett HP, Brooks WS, Halliday GM. Anti-inflammatory drugs protect against Alzheimer disease at low doses. Arch Neurol 2000; 57: 1586-91.
-
(2000)
Arch Neurol
, vol.57
, pp. 1586-91
-
-
Broe, G.A.1
Grayson, D.A.2
Creasey, H.M.3
Waite, L.M.4
Casey, B.J.5
Bennett, H.P.6
Brooks, W.S.7
Halliday, G.M.8
-
117
-
-
0034651101
-
Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists
-
Combs CK, Johnson DE, Karlo JC, Cannady SB, Landreth GE. Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J Neurosci 2000; 20: 558-67.
-
(2000)
J Neurosci
, vol.20
, pp. 558-67
-
-
Combs, C.K.1
Johnson, D.E.2
Karlo, J.C.3
Cannady, S.B.4
Landreth, G.E.5
-
118
-
-
34249821079
-
Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes
-
Moreira PI, Santos MS, Seica R, Oliveira CR. Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes. J Neurol Sci 2007; 257: 206-14.
-
(2007)
J Neurol Sci
, vol.257
, pp. 206-14
-
-
Moreira, P.I.1
Santos, M.S.2
Seica, R.3
Oliveira, C.R.4
-
119
-
-
0036796875
-
Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes
-
Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 2002; 23: 599-622.
-
(2002)
Endocr Rev
, vol.23
, pp. 599-622
-
-
Evans, J.L.1
Goldfine, I.D.2
Maddux, B.A.3
Grodsky, G.M.4
-
120
-
-
0037222391
-
Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy
-
Schmeichel AM, Schmelzer JD, Low PA. Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy. Diabetes 2003; 52: 165-71.
-
(2003)
Diabetes
, vol.52
, pp. 165-71
-
-
Schmeichel, A.M.1
Schmelzer, J.D.2
Low, P.A.3
-
121
-
-
0038321341
-
Increased vulnerability of brain mitochondria in diabetic (Goto-Kakizaki) rats with aging and amyloid-beta exposure
-
Moreira PI, Santos MS, Moreno AM, Seica R, Oliveira CR. Increased vulnerability of brain mitochondria in diabetic (Goto-Kakizaki) rats with aging and amyloid-beta exposure. Diabetes 2003; 52: 1449-56.
-
(2003)
Diabetes
, vol.52
, pp. 1449-56
-
-
Moreira, P.I.1
Santos, M.S.2
Moreno, A.M.3
Seica, R.4
Oliveira, C.R.5
-
122
-
-
0034864018
-
Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity
-
Calabrese V, Scapagnini G, Giuffrida Stella AM, Bates TE, Clark JB. Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochem Res 2001; 26: 739-64.
-
(2001)
Neurochem Res
, vol.26
, pp. 739-64
-
-
Calabrese, V.1
Scapagnini, G.2
Giuffrida Stella, A.M.3
Bates, T.E.4
Clark, J.B.5
-
123
-
-
0034962860
-
Mitochondria and degenerative disorders
-
Orth M, Schapira AH. Mitochondria and degenerative disorders. Am J Med Genet 2001; 106: 27-36.
-
(2001)
Am J Med Genet
, vol.106
, pp. 27-36
-
-
Orth, M.1
Schapira, A.H.2
-
124
-
-
3042806534
-
A 'mitochondrial cascade hypothesis' for sporadic Alzheimer's disease
-
Swerdlow RH, Khan SM. A 'mitochondrial cascade hypothesis' for sporadic Alzheimer's disease. Med Hypotheses 2004; 63: 8-20.
-
(2004)
Med Hypotheses
, vol.63
, pp. 8-20
-
-
Swerdlow, R.H.1
Khan, S.M.2
-
125
-
-
17644417472
-
Obesity, regional body fat distribution, and the metabolic syndrome in older men and women
-
Goodpaster BH, Krishnaswami S, Harris TB, Katsiaras A, Kritchevsky SB, Simonsick EM, Nevitt M, Holvoet P, Newman AB. Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med 2005; 165: 777-83.
-
(2005)
Arch Intern Med
, vol.165
, pp. 777-83
-
-
Goodpaster, B.H.1
Krishnaswami, S.2
Harris, T.B.3
Katsiaras, A.4
Kritchevsky, S.B.5
Simonsick, E.M.6
Nevitt, M.7
Holvoet, P.8
Newman, A.B.9
-
126
-
-
56149097176
-
Association of adiposity status and changes in early to mid-adulthood with incidence of Alzheimer's disease
-
Beydoun MA, Lhotsky A, Wang Y, Dal Forno G, An Y, Metter EJ, Ferrucci L, O'Brien R, Zonderman AB. Association of adiposity status and changes in early to mid-adulthood with incidence of Alzheimer's disease. Am J Epidemiol 2008; 168: 1179-89.
-
(2008)
Am J Epidemiol
, vol.168
, pp. 1179-89
-
-
Beydoun, M.A.1
Lhotsky, A.2
Wang, Y.3
Dal Forno, G.4
An, Y.5
Metter, E.J.6
Ferrucci, L.7
O'Brien, R.8
Zonderman, A.B.9
-
127
-
-
0038494075
-
An 18-year follow-up of overweight and risk of Alzheimer disease
-
Gustafson D, Rothenberg E, Blennow K, Steen B, Skoog I. An 18-year follow-up of overweight and risk of Alzheimer disease. Arch Intern Med 2003; 163: 1524-8.
-
(2003)
Arch Intern Med
, vol.163
, pp. 1524-8
-
-
Gustafson, D.1
Rothenberg, E.2
Blennow, K.3
Steen, B.4
Skoog, I.5
-
128
-
-
33846057321
-
The metabolic syndrome and Alzheimer disease
-
Razay G, Vreugdenhil A, Wilcock G. The metabolic syndrome and Alzheimer disease. Arch Neurol 2007; 64: 93-6.
-
(2007)
Arch Neurol
, vol.64
, pp. 93-6
-
-
Razay, G.1
Vreugdenhil, A.2
Wilcock, G.3
-
129
-
-
77951058598
-
Linking type 2 diabetes and Alzheimer's disease
-
Han W, Li C. Linking type 2 diabetes and Alzheimer's disease. Proc Natl Acad Sci USA 2010; 107: 6557-8.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 6557-8
-
-
Han, W.1
Li, C.2
-
130
-
-
44449179863
-
Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer's disease
-
Takeuchi M, Yamagishi S. Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer's disease. Curr Pharm Des 2008; 14: 973-8.
-
(2008)
Curr Pharm Des
, vol.14
, pp. 973-8
-
-
Takeuchi, M.1
Yamagishi, S.2
-
131
-
-
35748972367
-
Food-derived advanced glycation end products (AGEs): a novel therapeutic target for various disorders
-
Yamagishi S, Ueda S, Okuda S. Food-derived advanced glycation end products (AGEs): a novel therapeutic target for various disorders. Curr Pharm Des 2007; 13: 2832-6.
-
(2007)
Curr Pharm Des
, vol.13
, pp. 2832-6
-
-
Yamagishi, S.1
Ueda, S.2
Okuda, S.3
-
132
-
-
3342948649
-
Alternative routes for the formation of glyceraldehyde-derived AGEs (TAGE) in vivo
-
Takeuchi M, Yamagishi S. Alternative routes for the formation of glyceraldehyde-derived AGEs (TAGE) in vivo. Med Hypotheses 2004; 63: 453-5.
-
(2004)
Med Hypotheses
, vol.63
, pp. 453-5
-
-
Takeuchi, M.1
Yamagishi, S.2
-
133
-
-
3042637228
-
Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy
-
Yamagishi S, Takeuchi M, Inagaki Y, Nakamura K, Imaizumi T. Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy. Int J Clin Pharmacol Res 2003; 23: 129-34.
-
(2003)
Int J Clin Pharmacol Res
, vol.23
, pp. 129-34
-
-
Yamagishi, S.1
Takeuchi, M.2
Inagaki, Y.3
Nakamura, K.4
Imaizumi, T.5
-
134
-
-
0030885482
-
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
-
Smith MA, Harris PL, Sayre LM, Perry G. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc Natl Acad Sci USA 1997; 94: 9866-8.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9866-8
-
-
Smith, M.A.1
Harris, P.L.2
Sayre, L.M.3
Perry, G.4
-
135
-
-
0042611250
-
Alzheimer's disease - synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts
-
Munch G, Schinzel R, Loske C, Wong A, Durany N, Li JJ, Vlassara H, Smith MA, Perry G, Riederer P. Alzheimer's disease - synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts. J Neural Transm 1998; 105: 439-61.
-
(1998)
J Neural Transm
, vol.105
, pp. 439-61
-
-
Munch, G.1
Schinzel, R.2
Loske, C.3
Wong, A.4
Durany, N.5
Li, J.J.6
Vlassara, H.7
Smith, M.A.8
Perry, G.9
Riederer, P.10
-
136
-
-
70449732132
-
Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus
-
Valente T, Gella A, Fernandez-Busquets X, Unzeta M, Durany N. Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus. Neurobiol Dis 2010; 37: 67-76.
-
(2010)
Neurobiol Dis
, vol.37
, pp. 67-76
-
-
Valente, T.1
Gella, A.2
Fernandez-Busquets, X.3
Unzeta, M.4
Durany, N.5
-
137
-
-
0033608169
-
Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains
-
Kitamura Y, Shimohama S, Koike H, Kakimura J, Matsuoka Y, Nomura Y, Gebicke-Haerter PJ, Taniguchi T. Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains. Biochem Biophys Res Commun 1999; 254: 582-6.
-
(1999)
Biochem Biophys Res Commun
, vol.254
, pp. 582-6
-
-
Kitamura, Y.1
Shimohama, S.2
Koike, H.3
Kakimura, J.4
Matsuoka, Y.5
Nomura, Y.6
Gebicke-Haerter, P.J.7
Taniguchi, T.8
-
138
-
-
0036183630
-
The mechanisms of action of PPARs
-
Berger J, Moller DE. The mechanisms of action of PPARs. Annu Rev Med 2002; 53: 409-35.
-
(2002)
Annu Rev Med
, vol.53
, pp. 409-35
-
-
Berger, J.1
Moller, D.E.2
-
139
-
-
0033744396
-
Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review
-
Malinowski JM, Bolesta S. Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review. Clin Ther 2000; 22: 1151-68.
-
(2000)
Clin Ther
, vol.22
, pp. 1151-68
-
-
Malinowski, J.M.1
Bolesta, S.2
-
142
-
-
4544335597
-
Mild cognitive impairment as a diagnostic entity
-
Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004; 256: 183-94.
-
(2004)
J Intern Med
, vol.256
, pp. 183-94
-
-
Petersen, R.C.1
-
143
-
-
0021271971
-
Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
-
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-44.
-
(1984)
Neurology
, vol.34
, pp. 939-44
-
-
McKhann, G.1
Drachman, D.2
Folstein, M.3
Katzman, R.4
Price, D.5
Stadlan, E.M.6
-
144
-
-
79959479102
-
Efficacy of PPAR-gamma agonist pioglitazone in mild Alzheimer disease
-
in press.
-
Sato T, Hanyu H, Hirao K, Kanetaka H, Sakurai H, Iwamoto T. Efficacy of PPAR-gamma agonist pioglitazone in mild Alzheimer disease. Neurobiol Aging in press.
-
Neurobiol Aging
-
-
Sato, T.1
Hanyu, H.2
Hirao, K.3
Kanetaka, H.4
Sakurai, H.5
Iwamoto, T.6
-
145
-
-
33644592598
-
Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study
-
Watson GS, Cholerton BA, Reger MA, Baker LD, Plymate SR, Asthana S, Fishel MA, Kulstad JJ, Green PS, Cook DG, Kahn SE, Keeling ML, Craft S. Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study. Am J Geriatr Psychiatry 2005; 13: 950-8.
-
(2005)
Am J Geriatr Psychiatry
, vol.13
, pp. 950-8
-
-
Watson, G.S.1
Cholerton, B.A.2
Reger, M.A.3
Baker, L.D.4
Plymate, S.R.5
Asthana, S.6
Fishel, M.A.7
Kulstad, J.J.8
Green, P.S.9
Cook, D.G.10
Kahn, S.E.11
Keeling, M.L.12
Craft, S.13
-
146
-
-
33745266146
-
Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease
-
Rosiglitazone in Alzheimer's Disease Study Group
-
Risner ME, Saunders AM, Altman JF, Ormandy GC, Craft S, Foley IM, Zvartau-Hind ME, Hosford DA, Roses AD, Rosiglitazone in Alzheimer's Disease Study Group. Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease. Pharmacogenomics J 2006; 6: 246-54.
-
(2006)
Pharmacogenomics J
, vol.6
, pp. 246-54
-
-
Risner, M.E.1
Saunders, A.M.2
Altman, J.F.3
Ormandy, G.C.4
Craft, S.5
Foley, I.M.6
Zvartau-Hind, M.E.7
Hosford, D.A.8
Roses, A.D.9
-
147
-
-
58149265311
-
Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus
-
Hanyu H, Sato T, Kiuchi A, Sakurai H, Iwamoto T. Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus. J Am Geriatr Soc 2009; 57: 177-9.
-
(2009)
J Am Geriatr Soc
, vol.57
, pp. 177-9
-
-
Hanyu, H.1
Sato, T.2
Kiuchi, A.3
Sakurai, H.4
Iwamoto, T.5
-
148
-
-
3543142498
-
Intranasal insulin improves memory in humans
-
Benedict C, Hallschmid M, Hatke A, Schultes B, Fehm HL, Born J, Kern W. Intranasal insulin improves memory in humans. Psychoneuroendocrinology 2004; 29: 1326-34.
-
(2004)
Psychoneuroendocrinology
, vol.29
, pp. 1326-34
-
-
Benedict, C.1
Hallschmid, M.2
Hatke, A.3
Schultes, B.4
Fehm, H.L.5
Born, J.6
Kern, W.7
-
149
-
-
3242740239
-
Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
-
Thorne RG, Pronk GJ, Padmanabhan V, Frey WH 2nd. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 2004; 127: 481-96.
-
(2004)
Neuroscience
, vol.127
, pp. 481-96
-
-
Thorne, R.G.1
Pronk, G.J.2
Padmanabhan, V.3
Frey 2nd, W.H.4
-
150
-
-
40349091597
-
Intranasal insulin improves cognition and modulates beta-amyloid in early AD
-
Reger MA, Watson GS, Green PS, Wilkinson CW, Baker LD, Cholerton B, Fishel MA, Plymate SR, Breitner JC, DeGroodt W, Mehta P, Craft S. Intranasal insulin improves cognition and modulates beta-amyloid in early AD. Neurology 2008; 70: 440-8.
-
(2008)
Neurology
, vol.70
, pp. 440-8
-
-
Reger, M.A.1
Watson, G.S.2
Green, P.S.3
Wilkinson, C.W.4
Baker, L.D.5
Cholerton, B.6
Fishel, M.A.7
Plymate, S.R.8
Breitner, J.C.9
DeGroodt, W.10
Mehta, P.11
Craft, S.12
-
151
-
-
31844434789
-
Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype
-
Reger MA, Watson GS, Frey WH 2nd, Baker LD, Cholerton B, Keeling ML, Belongia DA, Fishel MA, Plymate SR, Schellenberg GD, Cherrier MM, Craft S. Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging 2006; 27: 451-8.
-
(2006)
Neurobiol Aging
, vol.27
, pp. 451-8
-
-
Reger, M.A.1
Watson, G.S.2
Frey 2nd, W.H.3
Baker, L.D.4
Cholerton, B.5
Keeling, M.L.6
Belongia, D.A.7
Fishel, M.A.8
Plymate, S.R.9
Schellenberg, G.D.10
Cherrier, M.M.11
Craft, S.12
-
152
-
-
79251634655
-
-
Columbia University, Institute for the Study of Aging, National Institute on Aging. Metformin in amnestic mild cognitive impairment (MCI). Available at (last accessed 19 August 2010).
-
Columbia University, Institute for the Study of Aging, National Institute on Aging. Metformin in amnestic mild cognitive impairment (MCI). Available at (last accessed 19 August 2010).
-
-
-
-
154
-
-
0021835896
-
Cognitive deficits in adolescents who developed diabetes in later life
-
Ryan C, Vaga A, Drash A. Cognitive deficits in adolescents who developed diabetes in later life. Pediatrics 1985; 75: 921-7.
-
(1985)
Pediatrics
, vol.75
, pp. 921-7
-
-
Ryan, C.1
Vaga, A.2
Drash, A.3
-
155
-
-
77952585217
-
Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice
-
Jolivalt CG, Hurford R, Lee CA, Dumaop W, Rockenstein E, Masliah E. Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice. Experiment Neurol 2010; 223: 422-31.
-
(2010)
Experiment Neurol
, vol.223
, pp. 422-31
-
-
Jolivalt, C.G.1
Hurford, R.2
Lee, C.A.3
Dumaop, W.4
Rockenstein, E.5
Masliah, E.6
-
156
-
-
62549138762
-
Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking
-
Sonnen JA, Larson EB, Gray SL, Wilson A, Kohama SG, Crane PK, Breitner JC, Montine TJ. Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking. Ann Neurol 2009; 65: 226-9.
-
(2009)
Ann Neurol
, vol.65
, pp. 226-9
-
-
Sonnen, J.A.1
Larson, E.B.2
Gray, S.L.3
Wilson, A.4
Kohama, S.G.5
Crane, P.K.6
Breitner, J.C.7
Montine, T.J.8
-
157
-
-
70349672704
-
Neuronal IGF-1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer's disease
-
Freude S, Hettich MH, Schumann C, Stöhr O, Koch L, Köhler C, Udelhoven M, Leeser U, Müller M, Kubota N, Kadowaki T, Krone W, Schröder H, Brüning JC, Schubert M. Neuronal IGF-1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer's disease. FASEB J 2009; 23: 3315-24.
-
(2009)
FASEB J
, vol.23
, pp. 3315-24
-
-
Freude, S.1
Hettich, M.H.2
Schumann, C.3
Stöhr, O.4
Koch, L.5
Köhler, C.6
Udelhoven, M.7
Leeser, U.8
Müller, M.9
Kubota, N.10
Kadowaki, T.11
Krone, W.12
Schröder, H.13
Brüning, J.C.14
Schubert, M.15
-
158
-
-
67649224051
-
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
-
Killick R, Scales G, Leroy K, Causevic M, Hooper C, Irvine EE, Choudhury AI, Drinkwater L, Kerr F, Al-Qassab H, Stephenson J, Yilmaz Z, Giese KP, Brion J-P, Withers DJ, Lovestone S. Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice. Biochem Biophys Res Comm 2009; 386: 257-62.
-
(2009)
Biochem Biophys Res Comm
, vol.386
, pp. 257-62
-
-
Killick, R.1
Scales, G.2
Leroy, K.3
Causevic, M.4
Hooper, C.5
Irvine, E.E.6
Choudhury, A.I.7
Drinkwater, L.8
Kerr, F.9
Al-Qassab, H.10
Stephenson, J.11
Yilmaz, Z.12
Giese, K.P.13
Brion, J.-P.14
Withers, D.J.15
Lovestone, S.16
-
159
-
-
71449108913
-
Reduced IGF-1 signaling delays age-associated proteotoxicity in mice
-
Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell 2009; 139: 1157-69.
-
(2009)
Cell
, vol.139
, pp. 1157-69
-
-
Cohen, E.1
Paulsson, J.F.2
Blinder, P.3
Burstyn-Cohen, T.4
Du, D.5
Estepa, G.6
Adame, A.7
Pham, H.M.8
Holzenberger, M.9
Kelly, J.W.10
Masliah, E.11
Dillin, A.12
-
160
-
-
33750987305
-
Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham study
-
Akomolafe A, Beiser A, Meigs JB, Au R, Green RC, Farrer LA, Wolf PA, Seshadri S. Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham study. Arch Neurol 2006; 63: 1551-5.
-
(2006)
Arch Neurol
, vol.63
, pp. 1551-5
-
-
Akomolafe, A.1
Beiser, A.2
Meigs, J.B.3
Au, R.4
Green, R.C.5
Farrer, L.A.6
Wolf, P.A.7
Seshadri, S.8
-
161
-
-
77953195401
-
Diabetes drug woes spell trouble for the entire drug family
-
Wadman W. Diabetes drug woes spell trouble for the entire drug family. Nature Med 2010; 16: 614.
-
(2010)
Nature Med
, vol.16
, pp. 614
-
-
Wadman, W.1
|