메뉴 건너뛰기




Volumn 32, Issue , 2014, Pages 107-118

TGF-β signaling to chromatin: How Smads regulate transcription during self-renewal and differentiation

Author keywords

Chromatin; Embryonic development; Embryonic stem cells; Smad; TGF superfamily; Transcription

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 4; POLYCOMB GROUP PROTEIN; SMAD PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; TRANSFORMING GROWTH FACTOR BETA; CHROMATIN;

EID: 84904463366     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2014.01.009     Document Type: Review
Times cited : (130)

References (121)
  • 1
    • 79952660821 scopus 로고    scopus 로고
    • Control of the embryonic stem cell state
    • Young R.A. Control of the embryonic stem cell state. Cell 2011, 144(6):940-954.
    • (2011) Cell , vol.144 , Issue.6 , pp. 940-954
    • Young, R.A.1
  • 2
    • 79953163994 scopus 로고    scopus 로고
    • Chromatin states in pluripotent, differentiated, and reprogrammed cells
    • Fisher C.L., Fisher A.G. Chromatin states in pluripotent, differentiated, and reprogrammed cells. Curr Opin Genet Dev 2011, 21(2):140-146.
    • (2011) Curr Opin Genet Dev , vol.21 , Issue.2 , pp. 140-146
    • Fisher, C.L.1    Fisher, A.G.2
  • 3
    • 84871699564 scopus 로고    scopus 로고
    • Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans
    • Adelman K., Lis J.T. Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans. Nat Rev Genet 2012, 13(10):720-731.
    • (2012) Nat Rev Genet , vol.13 , Issue.10 , pp. 720-731
    • Adelman, K.1    Lis, J.T.2
  • 4
    • 70249104647 scopus 로고    scopus 로고
    • Defining mechanisms that regulate RNA polymerase II transcription in vivo
    • Fuda N.J., Ardehali M.B., Lis J.T. Defining mechanisms that regulate RNA polymerase II transcription in vivo. Nature 2009, 461(7261):186-192.
    • (2009) Nature , vol.461 , Issue.7261 , pp. 186-192
    • Fuda, N.J.1    Ardehali, M.B.2    Lis, J.T.3
  • 5
    • 33847070442 scopus 로고    scopus 로고
    • The role of chromatin during transcription
    • Li B., Carey M., Workman J.L. The role of chromatin during transcription. Cell 2007, 128(4):707-719.
    • (2007) Cell , vol.128 , Issue.4 , pp. 707-719
    • Li, B.1    Carey, M.2    Workman, J.L.3
  • 6
    • 84860443136 scopus 로고    scopus 로고
    • Enhancers: emerging roles in cell fate specification
    • Ong C.-T., Corces V.G. Enhancers: emerging roles in cell fate specification. EMBO Rep 2012, 13(5):423-430.
    • (2012) EMBO Rep , vol.13 , Issue.5 , pp. 423-430
    • Ong, C.-T.1    Corces, V.G.2
  • 7
    • 78650304236 scopus 로고    scopus 로고
    • Charting histone modifications and the functional organization of mammalian genomes
    • Zhou V.W., Goren A., Bernstein B.E. Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet 2011, 12(1):7-18.
    • (2011) Nat Rev Genet , vol.12 , Issue.1 , pp. 7-18
    • Zhou, V.W.1    Goren, A.2    Bernstein, B.E.3
  • 8
    • 80052805267 scopus 로고    scopus 로고
    • Histone modification: cause or cog?
    • Henikoff S., Shilatifard A. Histone modification: cause or cog?. Trends Genet 2011, 27(10):389-396.
    • (2011) Trends Genet , vol.27 , Issue.10 , pp. 389-396
    • Henikoff, S.1    Shilatifard, A.2
  • 9
    • 84875149194 scopus 로고    scopus 로고
    • Regulation of nucleosome dynamics by histone modifications
    • Zentner G.E., Henikoff S. Regulation of nucleosome dynamics by histone modifications. Nat Struct Mol Biol 2013, 20(3):259-266.
    • (2013) Nat Struct Mol Biol , vol.20 , Issue.3 , pp. 259-266
    • Zentner, G.E.1    Henikoff, S.2
  • 11
    • 84876836223 scopus 로고    scopus 로고
    • Modification of enhancer chromatin: what, how, and why?
    • Calo E., Wysocka J. Modification of enhancer chromatin: what, how, and why?. Mol Cell 2013, 49(5):825-837.
    • (2013) Mol Cell , vol.49 , Issue.5 , pp. 825-837
    • Calo, E.1    Wysocka, J.2
  • 12
    • 79951516056 scopus 로고    scopus 로고
    • A unique chromatin signature uncovers early developmental enhancers in humans
    • Rada-Iglesias A., Bajpai R., Swigut T., Brugmann S.A., Flynn R.A., Wysocka J. A unique chromatin signature uncovers early developmental enhancers in humans. Nature 2011, 470(7333):279-283.
    • (2011) Nature , vol.470 , Issue.7333 , pp. 279-283
    • Rada-Iglesias, A.1    Bajpai, R.2    Swigut, T.3    Brugmann, S.A.4    Flynn, R.A.5    Wysocka, J.6
  • 13
    • 84861529303 scopus 로고    scopus 로고
    • Enhancers as information integration hubs in development: lessons from genomics
    • Buecker C., Wysocka J. Enhancers as information integration hubs in development: lessons from genomics. Trends Genet 2012, 28(6):276-284.
    • (2012) Trends Genet , vol.28 , Issue.6 , pp. 276-284
    • Buecker, C.1    Wysocka, J.2
  • 14
    • 84865249952 scopus 로고    scopus 로고
    • Transcription factors: from enhancer binding to developmental control
    • Spitz F., Furlong E.E.M. Transcription factors: from enhancer binding to developmental control. Nat Rev Genet 2012, 13(9):613-626.
    • (2012) Nat Rev Genet , vol.13 , Issue.9 , pp. 613-626
    • Spitz, F.1    Furlong, E.E.M.2
  • 15
    • 80052000538 scopus 로고    scopus 로고
    • Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism
    • Voss T.C., Schiltz R.L., Sung M.-H., Yen P.M., Stamatoyannopoulos J.A., Biddie S.C., et al. Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism. Cell 2011, 146(4):544-554.
    • (2011) Cell , vol.146 , Issue.4 , pp. 544-554
    • Voss, T.C.1    Schiltz, R.L.2    Sung, M.-H.3    Yen, P.M.4    Stamatoyannopoulos, J.A.5    Biddie, S.C.6
  • 16
    • 80455144479 scopus 로고    scopus 로고
    • Pioneer transcription factors: establishing competence for gene expression
    • Zaret K.S., Carroll J.S. Pioneer transcription factors: establishing competence for gene expression. Genes Dev 2011, 25(21):2227-2241.
    • (2011) Genes Dev , vol.25 , Issue.21 , pp. 2227-2241
    • Zaret, K.S.1    Carroll, J.S.2
  • 17
    • 84857054810 scopus 로고    scopus 로고
    • Factor mediated gene priming in pluripotent stem cells sets the stage for lineage specification
    • Dillon N. Factor mediated gene priming in pluripotent stem cells sets the stage for lineage specification. Bioessays 2012, 34(3):194-204.
    • (2012) Bioessays , vol.34 , Issue.3 , pp. 194-204
    • Dillon, N.1
  • 18
    • 79955795581 scopus 로고    scopus 로고
    • Paused RNA polymerase II as a developmental checkpoint
    • Levine M. Paused RNA polymerase II as a developmental checkpoint. Cell 2011, 145(4):502-511.
    • (2011) Cell , vol.145 , Issue.4 , pp. 502-511
    • Levine, M.1
  • 19
    • 84879260661 scopus 로고    scopus 로고
    • A double take on bivalent promoters
    • Voigt P., Tee W.W., Reinberg D. A double take on bivalent promoters. Genes Dev 2013, 27(12):1318-1338.
    • (2013) Genes Dev , vol.27 , Issue.12 , pp. 1318-1338
    • Voigt, P.1    Tee, W.W.2    Reinberg, D.3
  • 20
    • 84884626274 scopus 로고    scopus 로고
    • Chromatin sampling-an emerging perspective on targeting polycomb repressor proteins
    • Klose R.J., Cooper S., Farcas A.M., Blackledge N.P., Brockdorff N. Chromatin sampling-an emerging perspective on targeting polycomb repressor proteins. PLoS Genet 2013, 9(8):e1003717.
    • (2013) PLoS Genet , vol.9 , Issue.8
    • Klose, R.J.1    Cooper, S.2    Farcas, A.M.3    Blackledge, N.P.4    Brockdorff, N.5
  • 21
    • 61749097816 scopus 로고    scopus 로고
    • TGF-β superfamily signaling in embryonic development and homeostasis
    • Wu M.Y., Hill C.S. TGF-β superfamily signaling in embryonic development and homeostasis. Dev Cell 2009, 16(3):329-343.
    • (2009) Dev Cell , vol.16 , Issue.3 , pp. 329-343
    • Wu, M.Y.1    Hill, C.S.2
  • 22
    • 84866742560 scopus 로고    scopus 로고
    • TGFβ signalling in context
    • Massague J. TGFβ signalling in context. Nat Rev Mol Cell Biol 2012, 13(10):616-630.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.10 , pp. 616-630
    • Massague, J.1
  • 23
    • 36448936383 scopus 로고    scopus 로고
    • TGFβ-SMAD signal transduction: molecular specificity and functional flexibility
    • Schmierer B., Hill C.S. TGFβ-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 2007, 8(12):970-982.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , Issue.12 , pp. 970-982
    • Schmierer, B.1    Hill, C.S.2
  • 24
    • 70450187617 scopus 로고    scopus 로고
    • The regulation of TGFβ signal transduction
    • Moustakas A., Heldin C.-H. The regulation of TGFβ signal transduction. Development 2009, 136(22):3699-3714.
    • (2009) Development , vol.136 , Issue.22 , pp. 3699-3714
    • Moustakas, A.1    Heldin, C.-H.2
  • 25
    • 33746435907 scopus 로고    scopus 로고
    • Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning
    • Mesnard D., Guzman-Ayala M., Constam D.B. Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning. Development 2006, 133(13):2497-2505.
    • (2006) Development , vol.133 , Issue.13 , pp. 2497-2505
    • Mesnard, D.1    Guzman-Ayala, M.2    Constam, D.B.3
  • 26
    • 84875136981 scopus 로고    scopus 로고
    • Signaling pathways during maintenance and definitive endoderm differentiation of embryonic stem cells
    • Sui L., Bouwens L., Mfopou J.K. Signaling pathways during maintenance and definitive endoderm differentiation of embryonic stem cells. Int J Dev Biol 2013, 57(1):1-12.
    • (2013) Int J Dev Biol , vol.57 , Issue.1 , pp. 1-12
    • Sui, L.1    Bouwens, L.2    Mfopou, J.K.3
  • 27
    • 70349600692 scopus 로고    scopus 로고
    • Activin A-induced differentiation of embryonic stem cells into endoderm and pancreatic progenitors-the influence of differentiation factors and culture conditions
    • Sulzbacher S., Schroeder I.S., Truong T.T., Wobus A.M. Activin A-induced differentiation of embryonic stem cells into endoderm and pancreatic progenitors-the influence of differentiation factors and culture conditions. Stem Cell Rev 2009, 5(2):159-173.
    • (2009) Stem Cell Rev , vol.5 , Issue.2 , pp. 159-173
    • Sulzbacher, S.1    Schroeder, I.S.2    Truong, T.T.3    Wobus, A.M.4
  • 28
    • 49749152786 scopus 로고    scopus 로고
    • Patterning of mouse embryonic stem cell-derived pan-mesoderm by Activin A/Nodal and Bmp4 signaling requires Fibroblast Growth Factor activity
    • Willems E., Leyns L. Patterning of mouse embryonic stem cell-derived pan-mesoderm by Activin A/Nodal and Bmp4 signaling requires Fibroblast Growth Factor activity. Differentiation 2008, 76(7):745-759.
    • (2008) Differentiation , vol.76 , Issue.7 , pp. 745-759
    • Willems, E.1    Leyns, L.2
  • 30
    • 84856798558 scopus 로고    scopus 로고
    • Mouse pluripotent stem cells at a glance
    • Pauklin S., Pedersen R.A., Vallier L. Mouse pluripotent stem cells at a glance. J Cell Sci 2011, 124(Pt 22):3727-3732.
    • (2011) J Cell Sci , vol.124 , Issue.PART 22 , pp. 3727-3732
    • Pauklin, S.1    Pedersen, R.A.2    Vallier, L.3
  • 31
    • 77953802146 scopus 로고    scopus 로고
    • Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells
    • Galvin K.E., Travis E.D., Yee D., Magnuson T., Vivian J.L. Nodal signaling regulates the bone morphogenic protein pluripotency pathway in mouse embryonic stem cells. J Biol Chem 2010, 285(26):19747-19756.
    • (2010) J Biol Chem , vol.285 , Issue.26 , pp. 19747-19756
    • Galvin, K.E.1    Travis, E.D.2    Yee, D.3    Magnuson, T.4    Vivian, J.L.5
  • 32
    • 67650096520 scopus 로고    scopus 로고
    • Activin/Nodal signalling maintains pluripotency by controlling Nanog expression
    • Vallier L., Mendjan S., Brown S., Chng Z., Teo A., Smithers L.E., et al. Activin/Nodal signalling maintains pluripotency by controlling Nanog expression. Development 2009, 136(8):1339-1349.
    • (2009) Development , vol.136 , Issue.8 , pp. 1339-1349
    • Vallier, L.1    Mendjan, S.2    Brown, S.3    Chng, Z.4    Teo, A.5    Smithers, L.E.6
  • 33
    • 84883324006 scopus 로고    scopus 로고
    • Polycomb determines responses to smad2/3 signaling in embryonic stem cell differentiation and in reprogramming
    • Dahle O., Kuehn M.R. Polycomb determines responses to smad2/3 signaling in embryonic stem cell differentiation and in reprogramming. Stem Cells 2013, 31(8):1488-1497.
    • (2013) Stem Cells , vol.31 , Issue.8 , pp. 1488-1497
    • Dahle, O.1    Kuehn, M.R.2
  • 34
    • 78649847411 scopus 로고    scopus 로고
    • Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells
    • Fei T., Zhu S., Xia K., Zhang J., Li Z., Han J.D., et al. Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells. Cell Res 2010, 20(12):1306-1318.
    • (2010) Cell Res , vol.20 , Issue.12 , pp. 1306-1318
    • Fei, T.1    Zhu, S.2    Xia, K.3    Zhang, J.4    Li, Z.5    Han, J.D.6
  • 35
    • 84871546531 scopus 로고    scopus 로고
    • TGF-β-superfamily signaling regulates embryonic stem cell heterogeneity: self-renewal as a dynamic and regulated equilibrium
    • Galvin-Burgess K.E., Travis E.D., Pierson K.E., Vivian J.L. TGF-β-superfamily signaling regulates embryonic stem cell heterogeneity: self-renewal as a dynamic and regulated equilibrium. Stem Cells 2013, 31(1):48-58.
    • (2013) Stem Cells , vol.31 , Issue.1 , pp. 48-58
    • Galvin-Burgess, K.E.1    Travis, E.D.2    Pierson, K.E.3    Vivian, J.L.4
  • 36
    • 84863241921 scopus 로고    scopus 로고
    • Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation
    • Singh A.M., Reynolds D., Cliff T., Ohtsuka S., Mattheyses A.L., Sun Y., et al. Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation. Cell Stem Cell 2012, 10(3):312-326.
    • (2012) Cell Stem Cell , vol.10 , Issue.3 , pp. 312-326
    • Singh, A.M.1    Reynolds, D.2    Cliff, T.3    Ohtsuka, S.4    Mattheyses, A.L.5    Sun, Y.6
  • 37
    • 77952345331 scopus 로고    scopus 로고
    • The role of SMAD4 in human embryonic stem cell self-renewal and stem cell fate
    • Avery S., Zafarana G., Gokhale P.J., Andrews P.W. The role of SMAD4 in human embryonic stem cell self-renewal and stem cell fate. Stem Cells 2010, 28(5):863-873.
    • (2010) Stem Cells , vol.28 , Issue.5 , pp. 863-873
    • Avery, S.1    Zafarana, G.2    Gokhale, P.J.3    Andrews, P.W.4
  • 38
    • 84880081587 scopus 로고    scopus 로고
    • Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state
    • Sakaki-Yumoto M., Liu J., Ramalho-Santos M., Yoshida N., Derynck R. Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state. J Biol Chem 2013, 288(25):18546-18560.
    • (2013) J Biol Chem , vol.288 , Issue.25 , pp. 18546-18560
    • Sakaki-Yumoto, M.1    Liu, J.2    Ramalho-Santos, M.3    Yoshida, N.4    Derynck, R.5
  • 39
    • 39049121312 scopus 로고    scopus 로고
    • How the Smads regulate transcription
    • Ross S., Hill C.S. How the Smads regulate transcription. Int J Biochem Cell Biol 2008, 40(3):383-408.
    • (2008) Int J Biochem Cell Biol , vol.40 , Issue.3 , pp. 383-408
    • Ross, S.1    Hill, C.S.2
  • 40
    • 70350780570 scopus 로고    scopus 로고
    • Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-β pathways
    • Alarcon C., Zaromytidou A.I., Xi Q., Gao S., Yu J., Fujisawa S., et al. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-β pathways. Cell 2009, 139(4):757-769.
    • (2009) Cell , vol.139 , Issue.4 , pp. 757-769
    • Alarcon, C.1    Zaromytidou, A.I.2    Xi, Q.3    Gao, S.4    Yu, J.5    Fujisawa, S.6
  • 41
    • 36248995245 scopus 로고    scopus 로고
    • Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
    • Fuentealba L.C., Eivers E., Ikeda A., Hurtado C., Kuroda H., Pera E.M., et al. Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. Cell 2007, 131(5):980-993.
    • (2007) Cell , vol.131 , Issue.5 , pp. 980-993
    • Fuentealba, L.C.1    Eivers, E.2    Ikeda, A.3    Hurtado, C.4    Kuroda, H.5    Pera, E.M.6
  • 42
    • 0033106484 scopus 로고    scopus 로고
    • A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras
    • Kretzschmar M., Doody J., Timokhina I., Massague J. A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras. Genes Dev 1999, 13(7):804-816.
    • (1999) Genes Dev , vol.13 , Issue.7 , pp. 804-816
    • Kretzschmar, M.1    Doody, J.2    Timokhina, I.3    Massague, J.4
  • 43
    • 3142546336 scopus 로고    scopus 로고
    • Cyclin-dependent kinases regulate the antiproliferative function of Smads
    • Matsuura I., Denissova N.G., Wang G., He D., Long J., Liu F. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 2004, 430(6996):226-231.
    • (2004) Nature , vol.430 , Issue.6996 , pp. 226-231
    • Matsuura, I.1    Denissova, N.G.2    Wang, G.3    He, D.4    Long, J.5    Liu, F.6
  • 44
    • 33846688094 scopus 로고    scopus 로고
    • Balancing BMP signaling through integrated inputs into the Smad1 linker
    • Sapkota G., Alarcon C., Spagnoli F.M., Brivanlou A.H., Massague J. Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol Cell 2007, 25(3):441-454.
    • (2007) Mol Cell , vol.25 , Issue.3 , pp. 441-454
    • Sapkota, G.1    Alarcon, C.2    Spagnoli, F.M.3    Brivanlou, A.H.4    Massague, J.5
  • 45
    • 70350785179 scopus 로고    scopus 로고
    • Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-β signaling
    • Gao S., Alarcon C., Sapkota G., Rahman S., Chen P.Y., Goerner N., et al. Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-β signaling. Mol Cell 2009, 36(3):457-468.
    • (2009) Mol Cell , vol.36 , Issue.3 , pp. 457-468
    • Gao, S.1    Alarcon, C.2    Sapkota, G.3    Rahman, S.4    Chen, P.Y.5    Goerner, N.6
  • 46
    • 79959640061 scopus 로고    scopus 로고
    • A Smad action turnover switch operated by WW domain readers of a phosphoserine code
    • Aragon E., Goerner N., Zaromytidou A.I., Xi Q., Escobedo A., Massague J., et al. A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev 2011, 25(12):1275-1288.
    • (2011) Genes Dev , vol.25 , Issue.12 , pp. 1275-1288
    • Aragon, E.1    Goerner, N.2    Zaromytidou, A.I.3    Xi, Q.4    Escobedo, A.5    Massague, J.6
  • 47
    • 84875970693 scopus 로고    scopus 로고
    • Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock
    • Hashiguchi M., Mullins M.C. Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock. Development 2013, 140(9):1970-1980.
    • (2013) Development , vol.140 , Issue.9 , pp. 1970-1980
    • Hashiguchi, M.1    Mullins, M.C.2
  • 48
    • 84884844190 scopus 로고    scopus 로고
    • The cell-cycle state of stem cells determines cell fate propensity
    • Pauklin S., Vallier L. The cell-cycle state of stem cells determines cell fate propensity. Cell 2013, 155(1):135-147.
    • (2013) Cell , vol.155 , Issue.1 , pp. 135-147
    • Pauklin, S.1    Vallier, L.2
  • 49
    • 82455210962 scopus 로고    scopus 로고
    • Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3
    • Tang L.Y., Yamashita M., Coussens N.P., Tang Y., Wang X., Li C., et al. Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3. EMBO J 2011, 30(23):4777-4789.
    • (2011) EMBO J , vol.30 , Issue.23 , pp. 4777-4789
    • Tang, L.Y.1    Yamashita, M.2    Coussens, N.P.3    Tang, Y.4    Wang, X.5    Li, C.6
  • 50
    • 79959891289 scopus 로고    scopus 로고
    • Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities
    • Agricola E., Randall R.A., Gaarenstroom T., Dupont S., Hill C.S. Recruitment of TIF1γ to chromatin via its PHD finger-bromodomain activates its ubiquitin ligase and transcriptional repressor activities. Mol Cell 2011, 43(1):85-96.
    • (2011) Mol Cell , vol.43 , Issue.1 , pp. 85-96
    • Agricola, E.1    Randall, R.A.2    Gaarenstroom, T.3    Dupont, S.4    Hill, C.S.5
  • 51
    • 58149093172 scopus 로고    scopus 로고
    • FAM/USP9x, a deubiquitinating enzyme essential for TGFβ signaling, controls Smad4 monoubiquitination
    • Dupont S., Mamidi A., Cordenonsi M., Montagner M., Zacchigna L., Adorno M., et al. FAM/USP9x, a deubiquitinating enzyme essential for TGFβ signaling, controls Smad4 monoubiquitination. Cell 2009, 136(1):123-135.
    • (2009) Cell , vol.136 , Issue.1 , pp. 123-135
    • Dupont, S.1    Mamidi, A.2    Cordenonsi, M.3    Montagner, M.4    Zacchigna, L.5    Adorno, M.6
  • 52
    • 84455167662 scopus 로고    scopus 로고
    • A poised chromatin platform for TGF-β access to master regulators
    • Xi Q., Wang Z., Zaromytidou A.I., Zhang X.H., Chow-Tsang L.F., Liu J.X., et al. A poised chromatin platform for TGF-β access to master regulators. Cell 2011, 147(7):1511-1524.
    • (2011) Cell , vol.147 , Issue.7 , pp. 1511-1524
    • Xi, Q.1    Wang, Z.2    Zaromytidou, A.I.3    Zhang, X.H.4    Chow-Tsang, L.F.5    Liu, J.X.6
  • 54
    • 84859437880 scopus 로고    scopus 로고
    • Role of Smads in TGFβ signaling
    • Heldin C.H., Moustakas A. Role of Smads in TGFβ signaling. Cell Tissue Res 2012, 347(1):21-36.
    • (2012) Cell Tissue Res , vol.347 , Issue.1 , pp. 21-36
    • Heldin, C.H.1    Moustakas, A.2
  • 55
    • 51949114123 scopus 로고    scopus 로고
    • Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo
    • Miles W.O., Jaffray E., Campbell S.G., Takeda S., Bayston L.J., Basu S.P., et al. Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo. Genes Dev 2008, 22(18):2578-2590.
    • (2008) Genes Dev , vol.22 , Issue.18 , pp. 2578-2590
    • Miles, W.O.1    Jaffray, E.2    Campbell, S.G.3    Takeda, S.4    Bayston, L.J.5    Basu, S.P.6
  • 56
    • 0032483544 scopus 로고    scopus 로고
    • Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-β signaling
    • Shi Y., Wang Y.F., Jayaraman L., Yang H., Massague J., Pavletich N.P. Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-β signaling. Cell 1998, 94(5):585-594.
    • (1998) Cell , vol.94 , Issue.5 , pp. 585-594
    • Shi, Y.1    Wang, Y.F.2    Jayaraman, L.3    Yang, H.4    Massague, J.5    Pavletich, N.P.6
  • 57
    • 0032014216 scopus 로고    scopus 로고
    • Human Smad3 and Smad4 are sequence-specific transcription activators
    • Zawel L., Dai J.L., Buckhaults P., Zhou S., Kinzler K.W., Vogelstein B., et al. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell 1998, 1(4):611-617.
    • (1998) Mol Cell , vol.1 , Issue.4 , pp. 611-617
    • Zawel, L.1    Dai, J.L.2    Buckhaults, P.3    Zhou, S.4    Kinzler, K.W.5    Vogelstein, B.6
  • 58
    • 27744461702 scopus 로고    scopus 로고
    • Dpp-responsive silencers are bound by a trimeric Mad-Medea complex
    • Gao S., Steffen J., Laughon A. Dpp-responsive silencers are bound by a trimeric Mad-Medea complex. J Biol Chem 2005, 280(43):36158-36164.
    • (2005) J Biol Chem , vol.280 , Issue.43 , pp. 36158-36164
    • Gao, S.1    Steffen, J.2    Laughon, A.3
  • 59
    • 77953728005 scopus 로고    scopus 로고
    • Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-β effectors
    • BabuRajendran N., Palasingam P., Narasimhan K., Sun W., Prabhakar S., Jauch R., et al. Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-β effectors. Nucleic Acids Res 2010, 38(10):3477-3488.
    • (2010) Nucleic Acids Res , vol.38 , Issue.10 , pp. 3477-3488
    • BabuRajendran, N.1    Palasingam, P.2    Narasimhan, K.3    Sun, W.4    Prabhakar, S.5    Jauch, R.6
  • 60
    • 4344608791 scopus 로고    scopus 로고
    • A simple molecular complex mediates widespread BMP-induced repression during Drosophila development
    • Pyrowolakis G., Hartmann B., Muller B., Basler K., Affolter M. A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Dev Cell 2004, 7(2):229-240.
    • (2004) Dev Cell , vol.7 , Issue.2 , pp. 229-240
    • Pyrowolakis, G.1    Hartmann, B.2    Muller, B.3    Basler, K.4    Affolter, M.5
  • 62
    • 34548049239 scopus 로고    scopus 로고
    • The Decapentaplegic morphogen gradient: from pattern formation to growth regulation
    • Affolter M., Basler K. The Decapentaplegic morphogen gradient: from pattern formation to growth regulation. Nat Rev Genet 2007, 8(9):663-674.
    • (2007) Nat Rev Genet , vol.8 , Issue.9 , pp. 663-674
    • Affolter, M.1    Basler, K.2
  • 63
    • 66349137029 scopus 로고    scopus 로고
    • Finding partners: how BMPs select their targets
    • Blitz I.L., Cho K.W. Finding partners: how BMPs select their targets. Dev Dyn 2009, 238(6):1321-1331.
    • (2009) Dev Dyn , vol.238 , Issue.6 , pp. 1321-1331
    • Blitz, I.L.1    Cho, K.W.2
  • 65
    • 33751050017 scopus 로고    scopus 로고
    • Schnurri transcription factors from Drosophila and vertebrates can mediate Bmp signaling through a phylogenetically conserved mechanism
    • Yao L.C., Blitz I.L., Peiffer D.A., Phin S., Wang Y., Ogata S., et al. Schnurri transcription factors from Drosophila and vertebrates can mediate Bmp signaling through a phylogenetically conserved mechanism. Development 2006, 133(20):4025-4034.
    • (2006) Development , vol.133 , Issue.20 , pp. 4025-4034
    • Yao, L.C.1    Blitz, I.L.2    Peiffer, D.A.3    Phin, S.4    Wang, Y.5    Ogata, S.6
  • 66
    • 0029802485 scopus 로고    scopus 로고
    • A transcriptional partner for MAD proteins in TGF-β signalling
    • Chen X., Rubock M.J., Whitman M. A transcriptional partner for MAD proteins in TGF-β signalling. Nature 1996, 383(6602):691-696.
    • (1996) Nature , vol.383 , Issue.6602 , pp. 691-696
    • Chen, X.1    Rubock, M.J.2    Whitman, M.3
  • 67
  • 68
    • 42049092376 scopus 로고    scopus 로고
    • Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development
    • Silvestri C., Narimatsu M., von Both I., Liu Y., Tan N.B., Izzi L., et al. Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development. Dev Cell 2008, 14(3):411-423.
    • (2008) Dev Cell , vol.14 , Issue.3 , pp. 411-423
    • Silvestri, C.1    Narimatsu, M.2    von Both, I.3    Liu, Y.4    Tan, N.B.5    Izzi, L.6
  • 69
    • 84873495850 scopus 로고    scopus 로고
    • Integration of nodal and BMP signals in the heart requires FoxH1 to create left-right differences in cell migration rates that direct cardiac asymmetry
    • Lenhart K.F., Holtzman N.G., Williams J.R., Burdine R.D. Integration of nodal and BMP signals in the heart requires FoxH1 to create left-right differences in cell migration rates that direct cardiac asymmetry. PLoS Genet 2013, 9(1):e1003109.
    • (2013) PLoS Genet , vol.9 , Issue.1
    • Lenhart, K.F.1    Holtzman, N.G.2    Williams, J.R.3    Burdine, R.D.4
  • 70
  • 71
    • 0034007925 scopus 로고    scopus 로고
    • Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif
    • Germain S., Howell M., Esslemont G.M., Hill C.S. Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. Genes Dev 2000, 14(4):435-451.
    • (2000) Genes Dev , vol.14 , Issue.4 , pp. 435-451
    • Germain, S.1    Howell, M.2    Esslemont, G.M.3    Hill, C.S.4
  • 72
    • 0037080983 scopus 로고    scopus 로고
    • Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif
    • Randall R.A., Germain S., Inman G.J., Bates P.A., Hill C.S. Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif. EMBO J 2002, 21(1-2):145-156.
    • (2002) EMBO J , vol.21 , Issue.1-2 , pp. 145-156
    • Randall, R.A.1    Germain, S.2    Inman, G.J.3    Bates, P.A.4    Hill, C.S.5
  • 73
    • 0348013150 scopus 로고    scopus 로고
    • Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm induction
    • Kunwar P.S., Zimmerman S., Bennett J.T., Chen Y., Whitman M., Schier A.F. Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm induction. Development 2003, 130(23):5589-5599.
    • (2003) Development , vol.130 , Issue.23 , pp. 5589-5599
    • Kunwar, P.S.1    Zimmerman, S.2    Bennett, J.T.3    Chen, Y.4    Whitman, M.5    Schier, A.F.6
  • 74
    • 33749344476 scopus 로고    scopus 로고
    • Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription
    • Ross S., Cheung E., Petrakis T.G., Howell M., Kraus W.L., Hill C.S. Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription. EMBO J 2006, 25(19):4490-4502.
    • (2006) EMBO J , vol.25 , Issue.19 , pp. 4490-4502
    • Ross, S.1    Cheung, E.2    Petrakis, T.G.3    Howell, M.4    Kraus, W.L.5    Hill, C.S.6
  • 75
    • 59349117376 scopus 로고    scopus 로고
    • Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells
    • Guzman-Ayala M., Lee K.L., Mavrakis K.J., Goggolidou P., Norris D.P., Episkopou V. Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells. PLoS ONE 2009, 4(1):e4268.
    • (2009) PLoS ONE , vol.4 , Issue.1
    • Guzman-Ayala, M.1    Lee, K.L.2    Mavrakis, K.J.3    Goggolidou, P.4    Norris, D.P.5    Episkopou, V.6
  • 76
    • 79959814756 scopus 로고    scopus 로고
    • Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions
    • Lee K.L., Lim S.K., Orlov Y.L., Yit le Y., Yang H., Ang L.T., et al. Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions. PLoS Genet 2011, 7(6):e1002130.
    • (2011) PLoS Genet , vol.7 , Issue.6
    • Lee, K.L.1    Lim, S.K.2    Orlov, Y.L.3    Yit le, Y.4    Yang, H.5    Ang, L.T.6
  • 77
    • 79960888524 scopus 로고    scopus 로고
    • Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors
    • Brown S., Teo A., Pauklin S., Hannan N., Cho C.H.H., Lim B., et al. Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors. Stem Cells 2011, 29(8):1176-1185.
    • (2011) Stem Cells , vol.29 , Issue.8 , pp. 1176-1185
    • Brown, S.1    Teo, A.2    Pauklin, S.3    Hannan, N.4    Cho, C.H.H.5    Lim, B.6
  • 78
    • 74949142886 scopus 로고    scopus 로고
    • Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination
    • Fei T., Xia K., Li Z., Zhou B., Zhu S., Chen H., et al. Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination. Genome Res 2010, 20(1):36-44.
    • (2010) Genome Res , vol.20 , Issue.1 , pp. 36-44
    • Fei, T.1    Xia, K.2    Li, Z.3    Zhou, B.4    Zhu, S.5    Chen, H.6
  • 80
    • 58149468095 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor β signaling
    • Koinuma D., Tsutsumi S., Kamimura N., Taniguchi H., Miyazawa K., Sunamura M., et al. Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor β signaling. Mol Cell Biol 2009, 29(1):172-186.
    • (2009) Mol Cell Biol , vol.29 , Issue.1 , pp. 172-186
    • Koinuma, D.1    Tsutsumi, S.2    Kamimura, N.3    Taniguchi, H.4    Miyazawa, K.5    Sunamura, M.6
  • 81
    • 80051526119 scopus 로고    scopus 로고
    • Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas
    • Liu Z., Lin X., Cai Z., Zhang Z., Han C., Jia S., et al. Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. J Biol Chem 2011, 286(32):28520-28532.
    • (2011) J Biol Chem , vol.286 , Issue.32 , pp. 28520-28532
    • Liu, Z.1    Lin, X.2    Cai, Z.3    Zhang, Z.4    Han, C.5    Jia, S.6
  • 82
    • 80051925342 scopus 로고    scopus 로고
    • Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4 in HepG2 cells
    • Mizutani A., Koinuma D., Tsutsumi S., Kamimura N., Morikawa M., Suzuki H.I., et al. Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4 in HepG2 cells. J Biol Chem 2011, 286(34):29848-29860.
    • (2011) J Biol Chem , vol.286 , Issue.34 , pp. 29848-29860
    • Mizutani, A.1    Koinuma, D.2    Tsutsumi, S.3    Kamimura, N.4    Morikawa, M.5    Suzuki, H.I.6
  • 83
    • 80455178772 scopus 로고    scopus 로고
    • ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif
    • Morikawa M., Koinuma D., Tsutsumi S., Vasilaki E., Kanki Y., Heldin C.H., et al. ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif. Nucleic Acids Res 2011, 39(20):8712-8727.
    • (2011) Nucleic Acids Res , vol.39 , Issue.20 , pp. 8712-8727
    • Morikawa, M.1    Koinuma, D.2    Tsutsumi, S.3    Vasilaki, E.4    Kanki, Y.5    Heldin, C.H.6
  • 84
    • 80155137594 scopus 로고    scopus 로고
    • Master transcription factors determine cell-type-specific responses to TGF-β signaling
    • Mullen A.C., Orlando D.A., Newman J.J., Loven J., Kumar R.M., Bilodeau S., et al. Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell 2011, 147(3):565-576.
    • (2011) Cell , vol.147 , Issue.3 , pp. 565-576
    • Mullen, A.C.1    Orlando, D.A.2    Newman, J.J.3    Loven, J.4    Kumar, R.M.5    Bilodeau, S.6
  • 85
  • 86
    • 80155123782 scopus 로고    scopus 로고
    • Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration
    • Trompouki E., Bowman T.V., Lawton L.N., Fan Z.P., Wu D.C., DiBiase A., et al. Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell 2011, 147(3):577-589.
    • (2011) Cell , vol.147 , Issue.3 , pp. 577-589
    • Trompouki, E.1    Bowman, T.V.2    Lawton, L.N.3    Fan, Z.P.4    Wu, D.C.5    DiBiase, A.6
  • 87
    • 0038324070 scopus 로고    scopus 로고
    • Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins
    • Postigo A.A., Depp J.L., Taylor J.J., Kroll K.L. Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J 2003, 22(10):2453-2462.
    • (2003) EMBO J , vol.22 , Issue.10 , pp. 2453-2462
    • Postigo, A.A.1    Depp, J.L.2    Taylor, J.J.3    Kroll, K.L.4
  • 88
    • 0038324071 scopus 로고    scopus 로고
    • Opposing functions of ZEB proteins in the regulation of the TGFβ/BMP signaling pathway
    • Postigo A.A. Opposing functions of ZEB proteins in the regulation of the TGFβ/BMP signaling pathway. EMBO J 2003, 22(10):2443-2452.
    • (2003) EMBO J , vol.22 , Issue.10 , pp. 2443-2452
    • Postigo, A.A.1
  • 89
    • 73049085665 scopus 로고    scopus 로고
    • SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells
    • Chng Z., Teo A., Pedersen R.A., Vallier L. SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells. Stem Cell 2010, 6(1):59-70.
    • (2010) Stem Cell , vol.6 , Issue.1 , pp. 59-70
    • Chng, Z.1    Teo, A.2    Pedersen, R.A.3    Vallier, L.4
  • 90
    • 0842281496 scopus 로고    scopus 로고
    • Ski and SnoN: negative regulators of TGF-β signaling
    • Luo K. Ski and SnoN: negative regulators of TGF-β signaling. Curr Opin Genet Dev 2004, 14(1):65-70.
    • (2004) Curr Opin Genet Dev , vol.14 , Issue.1 , pp. 65-70
    • Luo, K.1
  • 91
    • 34548238145 scopus 로고    scopus 로고
    • Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation
    • Levy L., Howell M., Das D., Harkin S., Episkopou V., Hill C.S. Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Mol Cell Biol 2007, 27(17):6068-6083.
    • (2007) Mol Cell Biol , vol.27 , Issue.17 , pp. 6068-6083
    • Levy, L.1    Howell, M.2    Das, D.3    Harkin, S.4    Episkopou, V.5    Hill, C.S.6
  • 92
    • 58149239731 scopus 로고    scopus 로고
    • Ski and SnoN, potent negative regulators of TGF-β signaling
    • Deheuninck J., Luo K. Ski and SnoN, potent negative regulators of TGF-β signaling. Cell Res 2009, 19(1):47-57.
    • (2009) Cell Res , vol.19 , Issue.1 , pp. 47-57
    • Deheuninck, J.1    Luo, K.2
  • 93
    • 44849143723 scopus 로고    scopus 로고
    • Transforming growth factor-β suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation
    • Le Scolan E., Zhu Q., Wang L., Bandyopadhyay A., Javelaud D., Mauviel A., et al. Transforming growth factor-β suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation. Cancer Res 2008, 68(9):3277-3285.
    • (2008) Cancer Res , vol.68 , Issue.9 , pp. 3277-3285
    • Le Scolan, E.1    Zhu, Q.2    Wang, L.3    Bandyopadhyay, A.4    Javelaud, D.5    Mauviel, A.6
  • 94
    • 84869166825 scopus 로고    scopus 로고
    • The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells
    • Tsuneyoshi N., Tan E.K., Sadasivam A., Poobalan Y., Sumi T., Nakatsuji N., et al. The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells. Genes Dev 2012, 26(22):2471-2476.
    • (2012) Genes Dev , vol.26 , Issue.22 , pp. 2471-2476
    • Tsuneyoshi, N.1    Tan, E.K.2    Sadasivam, A.3    Poobalan, Y.4    Sumi, T.5    Nakatsuji, N.6
  • 95
    • 84862764922 scopus 로고    scopus 로고
    • TGF-β control of stem cell differentiation genes
    • Massague J., Xi Q. TGF-β control of stem cell differentiation genes. FEBS Lett 2012, 586(14):1953-1958.
    • (2012) FEBS Lett , vol.586 , Issue.14 , pp. 1953-1958
    • Massague, J.1    Xi, Q.2
  • 96
    • 0038369998 scopus 로고    scopus 로고
    • A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
    • Kang Y., Chen C.R., Massague J. A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell 2003, 11(4):915-926.
    • (2003) Mol Cell , vol.11 , Issue.4 , pp. 915-926
    • Kang, Y.1    Chen, C.R.2    Massague, J.3
  • 97
    • 43249102851 scopus 로고    scopus 로고
    • Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease
    • Cloos P.A.C., Christensen J., Agger K., Helin K. Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev 2008, 22(9):1115-1140.
    • (2008) Genes Dev , vol.22 , Issue.9 , pp. 1115-1140
    • Cloos, P.A.C.1    Christensen, J.2    Agger, K.3    Helin, K.4
  • 98
    • 80051537445 scopus 로고    scopus 로고
    • Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs
    • Kim S.W., Yoon S.J., Chuong E., Oyolu C., Wills A.E., Gupta R., et al. Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol 2011, 357(2):492-504.
    • (2011) Dev Biol , vol.357 , Issue.2 , pp. 492-504
    • Kim, S.W.1    Yoon, S.J.2    Chuong, E.3    Oyolu, C.4    Wills, A.E.5    Gupta, R.6
  • 99
    • 77956634439 scopus 로고    scopus 로고
    • Nodal signaling recruits the histone demethylase Jmjd3 to counteract polycomb-mediated repression at target genes
    • Dahle O., Kumar A., Kuehn M.R. Nodal signaling recruits the histone demethylase Jmjd3 to counteract polycomb-mediated repression at target genes. Sci Signal 2010, 3(127):ra48.
    • (2010) Sci Signal , vol.3 , Issue.127
    • Dahle, O.1    Kumar, A.2    Kuehn, M.R.3
  • 100
    • 84866788126 scopus 로고    scopus 로고
    • Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program
    • Estaras C., Akizu N., Garcia A., Beltran S., de la Cruz X., Martinez-Balbas M.A. Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program. Development 2012, 139(15):2681-2691.
    • (2012) Development , vol.139 , Issue.15 , pp. 2681-2691
    • Estaras, C.1    Akizu, N.2    Garcia, A.3    Beltran, S.4    de la Cruz, X.5    Martinez-Balbas, M.A.6
  • 102
    • 84880055491 scopus 로고    scopus 로고
    • Signal integration in TGF-β, WNT, and Hippo pathways
    • Attisano L., Wrana J.L. Signal integration in TGF-β, WNT, and Hippo pathways. F1000Prime Rep 2013, 5:17.
    • (2013) F1000Prime Rep , vol.5 , pp. 17
    • Attisano, L.1    Wrana, J.L.2
  • 103
    • 1542569747 scopus 로고    scopus 로고
    • Smad4 and β-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2
    • Hussein S.M., Duff E.K., Sirard C. Smad4 and β-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2. J Biol Chem 2003, 278(49):48805-48814.
    • (2003) J Biol Chem , vol.278 , Issue.49 , pp. 48805-48814
    • Hussein, S.M.1    Duff, E.K.2    Sirard, C.3
  • 104
    • 46049087598 scopus 로고    scopus 로고
    • TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
    • Varelas X., Sakuma R., Samavarchi-Tehrani P., Peerani R., Rao B.M., Dembowy J., et al. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol 2008, 10(7):837-848.
    • (2008) Nat Cell Biol , vol.10 , Issue.7 , pp. 837-848
    • Varelas, X.1    Sakuma, R.2    Samavarchi-Tehrani, P.3    Peerani, R.4    Rao, B.M.5    Dembowy, J.6
  • 105
    • 0032528236 scopus 로고    scopus 로고
    • The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-β-induced transcriptional activation
    • Feng X.H., Zhang Y., Wu R.Y., Derynck R. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-β-induced transcriptional activation. Genes Dev 1998, 12(14):2153-2163.
    • (1998) Genes Dev , vol.12 , Issue.14 , pp. 2153-2163
    • Feng, X.H.1    Zhang, Y.2    Wu, R.Y.3    Derynck, R.4
  • 106
    • 0032527756 scopus 로고    scopus 로고
    • TGF-β-stimulated cooperation of smad proteins with the coactivators CBP/p300
    • Janknecht R., Wells N.J., Hunter T. TGF-β-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev 1998, 12(14):2114-2119.
    • (1998) Genes Dev , vol.12 , Issue.14 , pp. 2114-2119
    • Janknecht, R.1    Wells, N.J.2    Hunter, T.3
  • 107
    • 0037043739 scopus 로고    scopus 로고
    • A component of the ARC/Mediator complex required for TGF β/Nodal signalling
    • Kato Y., Habas R., Katsuyama Y., Naar A.M., He X. A component of the ARC/Mediator complex required for TGF β/Nodal signalling. Nature 2002, 418(6898):641-646.
    • (2002) Nature , vol.418 , Issue.6898 , pp. 641-646
    • Kato, Y.1    Habas, R.2    Katsuyama, Y.3    Naar, A.M.4    He, X.5
  • 108
    • 38149019302 scopus 로고    scopus 로고
    • Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor β transcriptional program
    • Xi Q., He W., Zhang X.H., Le H.V., Massague J. Genome-wide impact of the BRG1 SWI/SNF chromatin remodeler on the transforming growth factor β transcriptional program. J Biol Chem 2008, 283(2):1146-1155.
    • (2008) J Biol Chem , vol.283 , Issue.2 , pp. 1146-1155
    • Xi, Q.1    He, W.2    Zhang, X.H.3    Le, H.V.4    Massague, J.5
  • 109
    • 65249173999 scopus 로고    scopus 로고
    • An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
    • Ho L., Jothi R., Ronan J.L., Cui K., Zhao K., Crabtree G.R. An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network. Proc Natl Acad Sci USA 2009, 106(13):5187-5191.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.13 , pp. 5187-5191
    • Ho, L.1    Jothi, R.2    Ronan, J.L.3    Cui, K.4    Zhao, K.5    Crabtree, G.R.6
  • 110
    • 65249180173 scopus 로고    scopus 로고
    • An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency
    • Ho L., Ronan J.L., Wu J., Staahl B.T., Chen L., Kuo A., et al. An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. Proc Natl Acad Sci USA 2009, 106(13):5181-5186.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.13 , pp. 5181-5186
    • Ho, L.1    Ronan, J.L.2    Wu, J.3    Staahl, B.T.4    Chen, L.5    Kuo, A.6
  • 111
    • 79961002967 scopus 로고    scopus 로고
    • EsBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function
    • Ho L., Miller E.L., Ronan J.L., Ho W.Q., Jothi R., Crabtree G.R. esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function. Nat Cell Biol 2011, 13(8):903-913.
    • (2011) Nat Cell Biol , vol.13 , Issue.8 , pp. 903-913
    • Ho, L.1    Miller, E.L.2    Ronan, J.L.3    Ho, W.Q.4    Jothi, R.5    Crabtree, G.R.6
  • 112
    • 55449104935 scopus 로고    scopus 로고
    • Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells
    • Landry J., Sharov A.A., Piao Y., Sharova L.V., Xiao H., Southon E., et al. Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. PLoS Genet 2008, 4(10):e1000241.
    • (2008) PLoS Genet , vol.4 , Issue.10
    • Landry, J.1    Sharov, A.A.2    Piao, Y.3    Sharova, L.V.4    Xiao, H.5    Southon, E.6
  • 113
    • 44649117905 scopus 로고    scopus 로고
    • Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
    • Chen X., Xu H., Yuan P., Fang F., Huss M., Vega V.B., et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 2008, 133(6):1106-1117.
    • (2008) Cell , vol.133 , Issue.6 , pp. 1106-1117
    • Chen, X.1    Xu, H.2    Yuan, P.3    Fang, F.4    Huss, M.5    Vega, V.B.6
  • 114
    • 84888038427 scopus 로고    scopus 로고
    • Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition
    • Lee M.T., Bonneau A.R., Takacs C.M., Bazzini A.A., Divito K.R., Fleming E.S., et al. Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition. Nature 2013, 503(7476):360-364.
    • (2013) Nature , vol.503 , Issue.7476 , pp. 360-364
    • Lee, M.T.1    Bonneau, A.R.2    Takacs, C.M.3    Bazzini, A.A.4    Divito, K.R.5    Fleming, E.S.6
  • 115
    • 84883134422 scopus 로고    scopus 로고
    • Pou5f1 transcription factor controls zygotic gene activation in vertebrates
    • Leichsenring M., Maes J., Mossner R., Driever W., Onichtchouk D. Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science 2013, 341(6149):1005-1009.
    • (2013) Science , vol.341 , Issue.6149 , pp. 1005-1009
    • Leichsenring, M.1    Maes, J.2    Mossner, R.3    Driever, W.4    Onichtchouk, D.5
  • 116
    • 0035890328 scopus 로고    scopus 로고
    • TGF-β inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3
    • Liu D., Black B.L., Derynck R. TGF-β inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev 2001, 15(22):2950-2966.
    • (2001) Genes Dev , vol.15 , Issue.22 , pp. 2950-2966
    • Liu, D.1    Black, B.L.2    Derynck, R.3
  • 117
    • 79551592864 scopus 로고    scopus 로고
    • Pluripotency factors regulate definitive endoderm specification through eomesodermin
    • Teo A.K.K., Arnold S.J., Trotter M.W.B., Brown S., Ang L.T., Chng Z., et al. Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev 2011, 25(3):238-250.
    • (2011) Genes Dev , vol.25 , Issue.3 , pp. 238-250
    • Teo, A.K.K.1    Arnold, S.J.2    Trotter, M.W.B.3    Brown, S.4    Ang, L.T.5    Chng, Z.6
  • 118
    • 84876928036 scopus 로고    scopus 로고
    • A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response
    • Ding N., Yu R.T., Subramaniam N., Sherman M.H., Wilson C., Rao R., et al. A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. Cell 2013, 153(3):601-613.
    • (2013) Cell , vol.153 , Issue.3 , pp. 601-613
    • Ding, N.1    Yu, R.T.2    Subramaniam, N.3    Sherman, M.H.4    Wilson, C.5    Rao, R.6
  • 119
    • 72849107786 scopus 로고    scopus 로고
    • Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells
    • Vallier L., Touboul T., Brown S., Cho C., Bilican B., Alexander M., et al. Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells. Stem Cells 2009, 27(11):2655-2666.
    • (2009) Stem Cells , vol.27 , Issue.11 , pp. 2655-2666
    • Vallier, L.1    Touboul, T.2    Brown, S.3    Cho, C.4    Bilican, B.5    Alexander, M.6
  • 121
    • 56549112482 scopus 로고    scopus 로고
    • An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-β signalling
    • Ikushima H., Komuro A., Isogaya K., Shinozaki M., Hellman U., Miyazawa K., et al. An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-β signalling. EMBO J 2008, 27(22):2955-2965.
    • (2008) EMBO J , vol.27 , Issue.22 , pp. 2955-2965
    • Ikushima, H.1    Komuro, A.2    Isogaya, K.3    Shinozaki, M.4    Hellman, U.5    Miyazawa, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.